Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CALCR Gene

Aliases for CALCR Gene

  • Calcitonin Receptor 2 3 5
  • CT-R 3 4
  • CTR1 3
  • CRT 3
  • CTR 3

External Ids for CALCR Gene

Previous GeneCards Identifiers for CALCR Gene

  • GC07M091589
  • GC07M092652
  • GC07M092665
  • GC07M092698
  • GC07M092891
  • GC07M093053
  • GC07M087664

Summaries for CALCR Gene

Entrez Gene Summary for CALCR Gene

  • This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for CALCR Gene

CALCR (Calcitonin Receptor) is a Protein Coding gene. Diseases associated with CALCR include Osteoporosis and Giant Cell Reparative Granuloma. Among its related pathways are RANK Signaling in Osteoclasts and Presynaptic function of Kainate receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for CALCR Gene

  • This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Tocris Summary for CALCR Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCR Gene

Genomics for CALCR Gene

Regulatory Elements for CALCR Gene

Enhancers for CALCR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CALCR on UCSC Golden Path with GeneCards custom track

Genomic Location for CALCR Gene

Chromosome:
7
Start:
93,424,487 bp from pter
End:
93,574,730 bp from pter
Size:
150,244 bases
Orientation:
Minus strand

Genomic View for CALCR Gene

Genes around CALCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCR Gene

Proteins for CALCR Gene

  • Protein details for CALCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30988-CALCR_HUMAN
    Recommended name:
    Calcitonin receptor
    Protein Accession:
    P30988
    Secondary Accessions:
    • A4D1G6
    • F5H605
    • O14585
    • Q13941
    • Q5ZGL8
    • Q659U6
    • Q6DJU8
    • Q6T712

    Protein attributes for CALCR Gene

    Size:
    508 amino acids
    Molecular mass:
    59352 Da
    Quaternary structure:
    • Interacts with GPRASP2.
    SequenceCaution:
    • Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CALCR Gene

neXtProt entry for CALCR Gene

Proteomics data for CALCR Gene at MOPED

Post-translational modifications for CALCR Gene

  • Glycosylation at Asn 46, Asn 91, Asn 143, and Asn 148
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CALCR Gene

Domains & Families for CALCR Gene

Gene Families for CALCR Gene

Suggested Antigen Peptide Sequences for CALCR Gene

Graphical View of Domain Structure for InterPro Entry

P30988

UniProtKB/Swiss-Prot:

CALCR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCR: view

Function for CALCR Gene

Molecular function for CALCR Gene

GENATLAS Biochemistry:
calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for osteoporosis,polymorphism associated with bone resorption
UniProtKB/Swiss-Prot Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Gene Ontology (GO) - Molecular Function for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0005515 protein binding IPI 7588285
genes like me logo Genes that share ontologies with CALCR: view
genes like me logo Genes that share phenotypes with CALCR: view

Animal Models for CALCR Gene

MGI Knock Outs for CALCR:

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCR

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCR Gene

Localization for CALCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCR Gene COMPARTMENTS Subcellular localization image for CALCR gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005887 integral component of plasma membrane NAS 7588285
genes like me logo Genes that share ontologies with CALCR: view

Pathways & Interactions for CALCR Gene

genes like me logo Genes that share pathways with CALCR: view

Gene Ontology (GO) - Biological Process for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 7588285
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,NAS 1331173
GO:0007190 NOT activation of adenylate cyclase activity IDA 15563840
GO:0043488 regulation of mRNA stability IEA --
genes like me logo Genes that share ontologies with CALCR: view

No data available for SIGNOR curated interactions for CALCR Gene

Drugs & Compounds for CALCR Gene

(26) Drugs for CALCR Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43
Salmon Calcitonin Approved, Investigational Pharma binder, Target, agonist 90
[<sup>125</sup>I]CT (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CT (salmon) Pharma Full agonist, Agonist 0
AC187 Pharma Antagonist 0

(18) Additional Compounds for CALCR Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP
Full agonist, Agonist
beta-CGRP
Full agonist, Agonist
CT (salmon)
Full agonist, Agonist
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1

(5) Tocris Compounds for CALCR Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with CALCR: view

Transcripts for CALCR Gene

Unigene Clusters for CALCR Gene

Calcitonin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALCR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: - - - -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CALCR Gene

GeneLoc Exon Structure for
CALCR
ECgene alternative splicing isoforms for
CALCR

Expression for CALCR Gene

mRNA expression in normal human tissues for CALCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCR Gene

This gene is overexpressed in Brain - Hypothalamus (x26.3).

Protein differential expression in normal tissues from HIPED for CALCR Gene

This gene is overexpressed in Nasal epithelium (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALCR Gene



SOURCE GeneReport for Unigene cluster for CALCR Gene Hs.489127

genes like me logo Genes that share expression patterns with CALCR: view

Protein tissue co-expression partners for CALCR Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CALCR Gene

Orthologs for CALCR Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALCR 35
  • 76.04 (n)
  • 70.62 (a)
CALCR 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCR 35
  • 88.89 (n)
  • 90.08 (a)
CT-R 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcr 35
  • 78.91 (n)
  • 77.8 (a)
Calcr 16
Calcr 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALCR 35
  • 99.48 (n)
  • 99.41 (a)
CALCR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calcr 35
  • 78.98 (n)
  • 80.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CALCR 35
  • 68.82 (n)
  • 64.3 (a)
-- 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia calcr 35
  • 66.14 (n)
  • 62.98 (a)
zebrafish
(Danio rerio)
Actinopterygii calcr 35
  • 64.45 (n)
  • 62.84 (a)
CABZ01088025.1 36
  • 49 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 28 (a)
Dh31-R1 36
  • 31 (a)
ManyToMany
hec 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C13B9.4 37
  • 32 (a)
pdfr-1 36
  • 22 (a)
OneToMany
Species with no ortholog for CALCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCR Gene

ENSEMBL:
Gene Tree for CALCR (if available)
TreeFam:
Gene Tree for CALCR (if available)

Paralogs for CALCR Gene

(13) SIMAP similar genes for CALCR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCR: view

Variants for CALCR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CALCR Gene

CALCR_HUMAN-P30988
Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Sequence variations from dbSNP and Humsavar for CALCR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1801197 - 93,426,441(-) GGAGC(C/T)GAGGA reference, missense
rs961261 -- 93,516,027(+) TTTTT(A/G)ATGAT intron-variant
rs972945 -- 93,472,338(+) ATGAC(A/G)TTCTC intron-variant
rs972946 -- 93,472,427(+) AGGTT(A/C/T)GATTG reference, missense
rs972978 -- 93,445,207(+) TCCCC(A/C/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCR Gene

Variant ID Type Subtype PubMed ID
nsv888737 CNV Loss 21882294
esv2666561 CNV Deletion 23128226
esv270500 CNV Insertion 20981092
esv272958 CNV Insertion 20981092
nsv464641 CNV Gain 19166990
nsv470380 CNV Gain 18288195
nsv5846 CNV Insertion 18451855
esv2734823 CNV Deletion 23290073
esv2734824 CNV Deletion 23290073
esv999961 CNV Deletion 20482838
esv2667635 CNV Deletion 23128226
esv2676719 CNV Deletion 23128226

Variation tolerance for CALCR Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCR Gene

Human Gene Mutation Database (HGMD)
CALCR

Disorders for CALCR Gene

MalaCards: The human disease database

(6) MalaCards diseases for CALCR Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
giant cell reparative granuloma
  • central giant cell granuloma
osteoporotic fracture
  • osteoporotic fractures
giant cell tumor
  • giant cell neoplasm
bone giant cell tumor
  • giant cell myeloma
- elite association - COSMIC cancer census association via MalaCards
Search CALCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCR

Genetic Association Database (GAD)
CALCR
Human Genome Epidemiology (HuGE) Navigator
CALCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCR
genes like me logo Genes that share disorders with CALCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCR Gene

Publications for CALCR Gene

  1. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. (PMID: 9817931) Taboulet J. … de Vernejoul M.-C. (Hum. Mol. Genet. 1998) 3 4 23 48 67
  2. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PMID: 1331173) Gorn A.H. … Goldring S.R. (J. Clin. Invest. 1992) 2 3 23
  3. Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PMID: 20015292) Qi T. … Hay D.L. (Br. J. Pharmacol. 2010) 23 25
  4. Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. (PMID: 19255718) Musumeci M. … Musumeci S. (J. Bone Miner. Metab. 2009) 3 23
  5. Functional expression of the calcitonin receptor by human T and B cells. (PMID: 19445988) Cafforio P. … Silvestris F. (Hum. Immunol. 2009) 3 23

Products for CALCR Gene

Sources for CALCR Gene

Content