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Aliases for CALCR Gene

Aliases for CALCR Gene

  • Calcitonin Receptor 2 3
  • CT-R 3 4
  • CTR1 3
  • CRT 3
  • CTR 3

External Ids for CALCR Gene

Previous GeneCards Identifiers for CALCR Gene

  • GC07M091589
  • GC07M092652
  • GC07M092665
  • GC07M092698
  • GC07M092891
  • GC07M093053
  • GC07M087664

Summaries for CALCR Gene

Entrez Gene Summary for CALCR Gene

  • This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for CALCR Gene

CALCR (Calcitonin Receptor) is a Protein Coding gene. Diseases associated with CALCR include osteoporosis and pigmented villonodular synovitis. Among its related pathways are Signaling by GPCR and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for CALCR Gene

  • This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin

Tocris Summary for CALCR Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCR Gene

Genomics for CALCR Gene

Regulatory Elements for CALCR Gene

Genomic Location for CALCR Gene

Chromosome:
7
Start:
93,424,487 bp from pter
End:
93,574,730 bp from pter
Size:
150,244 bases
Orientation:
Minus strand

Genomic View for CALCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCR Gene

Proteins for CALCR Gene

  • Protein details for CALCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30988-CALCR_HUMAN
    Recommended name:
    Calcitonin receptor
    Protein Accession:
    P30988
    Secondary Accessions:
    • A4D1G6
    • F5H605
    • O14585
    • Q13941
    • Q5ZGL8
    • Q659U6
    • Q6DJU8
    • Q6T712

    Protein attributes for CALCR Gene

    Size:
    508 amino acids
    Molecular mass:
    59352 Da
    Quaternary structure:
    • Interacts with GPRASP2.
    SequenceCaution:
    • Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CALCR Gene

neXtProt entry for CALCR Gene

Proteomics data for CALCR Gene at MOPED

Post-translational modifications for CALCR Gene

  • Glycosylation at Asn 46, Asn 91, Asn 143, and Asn 148
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CALCR Gene

Domains & Families for CALCR Gene

Gene Families for CALCR Gene

Suggested Antigen Peptide Sequences for CALCR Gene

Graphical View of Domain Structure for InterPro Entry

P30988

UniProtKB/Swiss-Prot:

CALCR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCR: view

Function for CALCR Gene

Molecular function for CALCR Gene

GENATLAS Biochemistry:
calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for osteoporosis,polymorphism associated with bone resorption
UniProtKB/Swiss-Prot Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin

Gene Ontology (GO) - Molecular Function for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004948 calcitonin receptor activity IEA --
GO:0005515 protein binding IPI 7588285
genes like me logo Genes that share ontologies with CALCR: view
genes like me logo Genes that share phenotypes with CALCR: view

Animal Models for CALCR Gene

MGI Knock Outs for CALCR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CALCR Gene

Localization for CALCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCR Gene COMPARTMENTS Subcellular localization image for CALCR gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle --
GO:0005829 cytosol IDA 8078488
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7588285
GO:0005929 cilium --
genes like me logo Genes that share ontologies with CALCR: view

Pathways & Interactions for CALCR Gene

genes like me logo Genes that share pathways with CALCR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 7588285
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway NAS 1331173
GO:0007190 NOT activation of adenylate cyclase activity IDA 15563840
genes like me logo Genes that share ontologies with CALCR: view

No data available for SIGNOR curated interactions for CALCR Gene

Drugs & Compounds for CALCR Gene

(26) Drugs for CALCR Gene - From: NovoSeek, DGIdb, DrugBank, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 42
Salmon Calcitonin Approved, Investigational Pharma binder, Target, agonist 48
Dexamethasone Approved, Investigational Pharma Agonist 1806
Estradiol Approved, Investigational Pharma Sex hormone 1057
Calcitriol Approved Nutra TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist 158

(17) Additional Compounds for CALCR Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP
Full agonist, Agonist
beta-CGRP
Full agonist, Agonist
CT (salmon)
Full agonist, Agonist
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
genes like me logo Genes that share compounds with CALCR: view

Transcripts for CALCR Gene

mRNA/cDNA for CALCR Gene

Unigene Clusters for CALCR Gene

Calcitonin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: - - - -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CALCR Gene

GeneLoc Exon Structure for
CALCR
ECgene alternative splicing isoforms for
CALCR

Expression for CALCR Gene

mRNA expression in normal human tissues for CALCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCR Gene

This gene is overexpressed in Brain - Hypothalamus (x26.3).

Protein differential expression in normal tissues from HIPED for CALCR Gene

This gene is overexpressed in Nasal epithelium (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALCR Gene



SOURCE GeneReport for Unigene cluster for CALCR Gene Hs.489127

genes like me logo Genes that share expression patterns with CALCR: view

Protein tissue co-expression partners for CALCR Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CALCR Gene

Orthologs for CALCR Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALCR 35
  • 76.04 (n)
  • 70.62 (a)
CALCR 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCR 35
  • 88.89 (n)
  • 90.08 (a)
CT-R 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcr 35
  • 78.91 (n)
  • 77.8 (a)
Calcr 16
Calcr 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALCR 35
  • 99.48 (n)
  • 99.41 (a)
CALCR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calcr 35
  • 78.98 (n)
  • 80.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CALCR 35
  • 68.82 (n)
  • 64.3 (a)
-- 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia calcr 35
  • 66.14 (n)
  • 62.98 (a)
zebrafish
(Danio rerio)
Actinopterygii calcr 35
  • 64.45 (n)
  • 62.84 (a)
CABZ01088025.1 36
  • 49 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 28 (a)
Dh31-R1 36
  • 31 (a)
ManyToMany
hec 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C13B9.4 37
  • 32 (a)
pdfr-1 36
  • 22 (a)
OneToMany
Species with no ortholog for CALCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCR Gene

ENSEMBL:
Gene Tree for CALCR (if available)
TreeFam:
Gene Tree for CALCR (if available)

Paralogs for CALCR Gene

(13) SIMAP similar genes for CALCR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCR: view

Variants for CALCR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CALCR Gene

P30988-CALCR_HUMAN
Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture

Sequence variations from dbSNP and Humsavar for CALCR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs17080 -- 93,565,632(+) TGCTG(A/G)GATTT intron-variant
rs721315 -- 93,498,045(+) CACGT(C/T)TTTGT intron-variant
rs721381 -- 93,518,960(+) AAAAA(A/T)TTTTT intron-variant
rs757033 -- 93,442,113(+) AGATA(C/T)GCAAG intron-variant
rs757034 -- 93,443,012(+) TGTAC(A/G)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCR Gene

Variant ID Type Subtype PubMed ID
nsv888737 CNV Loss 21882294
esv2666561 CNV Deletion 23128226
esv270500 CNV Insertion 20981092
esv272958 CNV Insertion 20981092
nsv464641 CNV Gain 19166990
nsv470380 CNV Gain 18288195
nsv5846 CNV Insertion 18451855
esv2734823 CNV Deletion 23290073
esv2734824 CNV Deletion 23290073
esv999961 CNV Deletion 20482838
esv2667635 CNV Deletion 23128226
esv2676719 CNV Deletion 23128226

Variation tolerance for CALCR Gene

Residual Variation Intolerance Score: 18.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCR Gene

HapMap Linkage Disequilibrium report
CALCR
Human Gene Mutation Database (HGMD)
CALCR

Disorders for CALCR Gene

MalaCards: The human disease database

(6) MalaCards diseases for CALCR Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
pigmented villonodular synovitis
  • testicular germ cell tumor
giant cell reparative granuloma
  • central giant cell granuloma
sparganosis
  • infection by sparganum
osteoporotic fracture
  • osteoporotic fractures
- elite association
Search CALCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCR

Genetic Association Database (GAD)
CALCR
Human Genome Epidemiology (HuGE) Navigator
CALCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCR
genes like me logo Genes that share disorders with CALCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCR Gene

Publications for CALCR Gene

  1. Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PMID: 20015292) Qi T. … Hay D.L. (Br. J. Pharmacol. 2010) 23 25 67
  2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 23 25 67
  3. Cloning, characterization, and expression of a calcitonin receptor from guinea pig brain. (PMID: 9231703) Sarkar A. … Dickerson I.M. (J. Neurochem. 1997) 23 25 67
  4. Intracellular calcium increases mediated by a recombinant human calcitonin receptor. (PMID: 7610922) Stroop S.D. … Moore E.E. (J. Bone Miner. Res. 1995) 23 25 67
  5. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PMID: 1331173) Gorn A.H. … Goldring S.R. (J. Clin. Invest. 1992) 2 23 67

Products for CALCR Gene

Sources for CALCR Gene

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