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Aliases for CALCR Gene

Aliases for CALCR Gene

  • Calcitonin Receptor 2 3
  • CT-R 3 4
  • CRT 3 6
  • CTR1 3
  • CTR 3

External Ids for CALCR Gene

Previous GeneCards Identifiers for CALCR Gene

  • GC07M091589
  • GC07M092652
  • GC07M092665
  • GC07M092698
  • GC07M092891
  • GC07M093053
  • GC07M087664

Summaries for CALCR Gene

Entrez Gene Summary for CALCR Gene

  • This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for CALCR Gene

CALCR (Calcitonin Receptor) is a Protein Coding gene. Diseases associated with CALCR include osteoporosis and lung cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor activity and calcitonin receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for CALCR Gene

  • This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin

Tocris Summary for CALCR Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCR Gene

Genomics for CALCR Gene

Regulatory Elements for CALCR Gene

Genomic Location for CALCR Gene

Start:
93,424,487 bp from pter
End:
93,574,730 bp from pter
Size:
150,244 bases
Orientation:
Minus strand

Genomic View for CALCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCR Gene

Proteins for CALCR Gene

  • Protein details for CALCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30988-CALCR_HUMAN
    Recommended name:
    Calcitonin receptor
    Protein Accession:
    P30988
    Secondary Accessions:
    • A4D1G6
    • F5H605
    • O14585
    • Q13941
    • Q5ZGL8
    • Q659U6
    • Q6DJU8
    • Q6T712

    Protein attributes for CALCR Gene

    Size:
    508 amino acids
    Molecular mass:
    59352 Da
    Quaternary structure:
    • Interacts with GPRASP2.
    SequenceCaution:
    • Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CALCR Gene

neXtProt entry for CALCR Gene

Proteomics data for CALCR Gene at MOPED

Post-translational modifications for CALCR Gene

  • Glycosylation at Asn46, Asn91, Asn143, and Asn148
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCR Gene

No data available for DME Specific Peptides for CALCR Gene

Domains for CALCR Gene

Gene Families for CALCR Gene

HGNC:
  • CALCR :GPCR / Class B : Calcitonin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for CALCR Gene

Graphical View of Domain Structure for InterPro Entry

P30988

UniProtKB/Swiss-Prot:

CALCR_HUMAN :
  • P30988
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCR: view

Function for CALCR Gene

Molecular function for CALCR Gene

GENATLAS Biochemistry: calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for osteoporosis,polymorphism associated with bone resorption
UniProtKB/Swiss-Prot Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin

Gene Ontology (GO) - Molecular Function for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004948 calcitonin receptor activity IEA --
GO:0005515 protein binding IPI 14722252
genes like me logo Genes that share ontologies with CALCR: view
genes like me logo Genes that share phenotypes with CALCR: view

Animal Models for CALCR Gene

MGI Knock Outs for CALCR:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CALCR Gene

Localization for CALCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCR Gene COMPARTMENTS Subcellular localization image for CALCR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7588285
GO:0005929 cilium --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CALCR: view

Pathways for CALCR Gene

genes like me logo Genes that share pathways with CALCR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IDA 7588285
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway NAS 1331173
GO:0007190 NOT activation of adenylate cyclase activity IDA 15563840
genes like me logo Genes that share ontologies with CALCR: view

Compounds for CALCR Gene

(5) Tocris Compounds for CALCR Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(2) Drugbank Compounds for CALCR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pramlintide
151126-32-8 target agonist
Salmon Calcitonin
  • Calcitonin 1 precursor
47931-85-1 target agonist

(12) IUPHAR Ligand for CALCR Gene

Ligand Type Action Affinity Pubmed IDs
calcitonin Agonist Full agonist 11.2
CT (salmon) Agonist Full agonist 11.1
[125I]CT (human) Agonist Full agonist 10
[125I]CT (salmon) Agonist Full agonist 10
amylin Agonist Full agonist 9.5
amylin Agonist Full agonist 9.5
CT-(8-32) (salmon) Antagonist Antagonist 9
alpha-CGRP Agonist Full agonist 8.4
adrenomedullin Agonist Full agonist 7.7
beta-CGRP Agonist Full agonist 7.2
AC187 Antagonist Antagonist 7.15
adrenomedullin 2/intermedin Agonist Full agonist 6.5

(23) Novoseek inferred chemical compound relationships for CALCR Gene

Compound -log(P) Hits PubMed IDs
tartrate 60.7 6
adenylate 55.9 13
cyclic amp 47.8 11
calcitriol 41.8 3
1,25 dihydroxy vitamin d3 39.7 1
genes like me logo Genes that share compounds with CALCR: view

Transcripts for CALCR Gene

Unigene Clusters for CALCR Gene

Calcitonin receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: - - - -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CALCR Gene

GeneLoc Exon Structure for
CALCR
ECgene alternative splicing isoforms for
CALCR

Expression for CALCR Gene

mRNA expression in normal human tissues for CALCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCR Gene

This gene is overexpressed in Brain - Hypothalamus (26.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALCR Gene

SOURCE GeneReport for Unigene cluster for CALCR Gene Hs.489127

genes like me logo Genes that share expressions with CALCR: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CALCR Gene

Orthologs for CALCR Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCR 35
  • 99.48 (n)
  • 99.41 (a)
CALCR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALCR 35
  • 76.04 (n)
  • 70.62 (a)
CALCR 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCR 35
  • 88.89 (n)
  • 90.08 (a)
CT-R 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcr 35
  • 78.91 (n)
  • 77.8 (a)
Calcr 16
Calcr 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Calcr 35
  • 78.98 (n)
  • 80.29 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 63 (a)
ManyToMany
CALCR 35
  • 68.82 (n)
  • 64.3 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia calcr 35
  • 66.14 (n)
  • 62.98 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01088025.1 36
  • 49 (a)
ManyToMany
calcr 35
  • 64.45 (n)
  • 62.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dh31-R1 36
  • 31 (a)
ManyToMany
hec 36
  • 25 (a)
ManyToMany
EG:BACR25B3.3 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea pdfr-1 36
  • 22 (a)
OneToMany
C13B9.4 37
  • 32 (a)
Species with no ortholog for CALCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCR Gene

ENSEMBL:
Gene Tree for CALCR (if available)
TreeFam:
Gene Tree for CALCR (if available)

Paralogs for CALCR Gene

Selected SIMAP similar genes for CALCR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCR: view

Variants for CALCR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CALCR Gene

P30988-CALCR_HUMAN
Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture

Sequence variations from dbSNP and Humsavar for CALCR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs17080 -- 93,565,632(+) TGCTG(A/G)GATTT intron-variant
rs713137 -- 93,538,860(+) GATAT(G/T)AGTTG intron-variant
rs721315 -- 93,498,045(+) CACGT(C/T)TTTGT intron-variant
rs721381 -- 93,518,960(+) AAAAA(A/T)TTTTT intron-variant
rs724683 -- 93,533,603(+) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCR Gene

Variant ID Type Subtype PubMed ID
nsv888737 CNV Loss 21882294
esv2666561 CNV Deletion 23128226
esv270500 CNV Insertion 20981092
esv272958 CNV Insertion 20981092
nsv464641 CNV Gain 19166990
nsv470380 CNV Gain 18288195
nsv5846 CNV Insertion 18451855
esv2734823 CNV Deletion 23290073
esv2734824 CNV Deletion 23290073
esv999961 CNV Deletion 20482838
esv2667635 CNV Deletion 23128226
esv2676719 CNV Deletion 23128226

Relevant External Links for CALCR Gene

HapMap Linkage Disequilibrium report
CALCR
Human Gene Mutation Database (HGMD)
CALCR

Disorders for CALCR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CALCR Gene including...

Search for CALCR Gene in MalaCards »

(1) OMIM Diseases for CALCR Gene (114131)

(1) University of Copenhagen DISEASES for CALCR Gene

(21) Novoseek inferred disease relationships for CALCR Gene

Disease -log(P) Hits PubMed IDs
osteoclastoma 62.2 2
osteoporosis 47.1 4
osteopenia 45.2 1
central giant cell granuloma 43.5 1
thyroid carcinoma medullary 37.7 2

Relevant External Links for CALCR

Genetic Association Database (GAD)
CALCR
Human Genome Epidemiology (HuGE) Navigator
CALCR
genes like me logo Genes that share disorders with CALCR: view

No data available for UniProtKB/Swiss-Prot for CALCR Gene

Publications for CALCR Gene

  1. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PMID: 1331173) Gorn A.H. … Goldring S.R. (J. Clin. Invest. 1992) 2 3 4 23
  2. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. (PMID: 9817931) Taboulet J. … de Vernejoul M.-C. (Hum. Mol. Genet. 1998) 3 4 23 48
  3. A novel calcitonin receptor gene in human osteoclasts from normal bone marrow. (PMID: 10570950) Nishikawa T. … Koshihara Y. (FEBS Lett. 1999) 3 4 23
  4. Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women. (PMID: 9675109) Masi L. … Brandi M.L. (Biochem. Biophys. Res. Commun. 1998) 4 23 48
  5. Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women. (PMID: 9571205) Masi L. … Brandi M.L. (Biochem. Biophys. Res. Commun. 1998) 3 4 23

Products for CALCR Gene

  • Addgene plasmids for CALCR

Sources for CALCR Gene

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