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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALCR Gene

protein-coding   GIFtS: 68
GCID: GC07M093053

calcitonin receptor
 Explore 39 diseases affiliated with
CALCR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CALCR    

Aliases
for CALCR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcitonin Receptor1 2
CTR1 2
CT-R2 3
CRT2 5
CTR12

External Ids:    HGNC: 14401   Entrez Gene: 7992   Ensembl: ENSG000000049487   OMIM: 1141315   UniProtKB: P309883   

Export aliases for CALCR gene to outside databases

Previous GC identifers: GC07M091589 GC07M092652 GC07M092665 GC07M092698 GC07M092891 GC07M087664


Summaries
for CALCR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CALCR:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven
transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis
and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations
in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988
Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding
protein that is sensitive to cholera toxin

summary for CALCR:
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight
subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;
high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels
present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit
bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT
receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II
diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form
the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main
function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCR (Calcitonin receptor)


Genomic Views
for CALCR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALCR gene promoter:
         HOXA9B   HOXA9   POU3F2 (N-Oct-5a)   Meis-1a   POU3F2 (N-Oct-5b)   POU3F2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CALCR promoter sequence
   Search SABiosciences Chromatin IP Primers for CALCR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

CALCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M093053:  view genomic region     (about GC identifiers)

Start:
 93,053,799 bp from pter      End:
 93,204,042 bp from pter
Size:
 150,244 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 92,383,112-92,533,218     

Proteins
for CALCR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988 (See protein sequence)
Recommended Name: Calcitonin receptor precursor  
Size: 490 amino acids; 57303 Da
Subunit: Interacts with GPRASP2
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O14585 Q13941 Q6DJU8 Q6T712
Alternative splicing: 3 isoforms:  P30988-1   P30988-2   P30988-3   

Explore the universe of human proteins at neXtProt for CALCR: NX_P30988

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30988

    • CALCR Protein expression data from MOPED and PaxDb:    About this image 
    CALCR Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158209.1  NP_001158210.1  NP_001733.1  

    ENSEMBL proteins: 
     ENSP00000399552   ENSP00000377959   ENSP00000389295   ENSP00000391369   ENSP00000413179  
     ENSP00000352561   ENSP00000353385  
    Reactome Protein details: P30988
    Human Recombinant Protein Products for CALCR: 
    EMD Millipore Purified and/or Recombinant CALCR Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): CALCR
    OriGene Custom Protein Services for CALCR 
    GenScript Custom Purified and Recombinant Proteins Services for CALCR
    Novus Biologicals CALCR Proteins
    Novus Biologicals CALCR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CALCR

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS7619207
    GO:0016021integral to membrane ----
    GO:0030424axon ----

    CALCR for ontologies           About GeneDecksing



    CALCR Antibody Products: 
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    Abcam antibodies for CALCR 
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    ThermoFisher Antibody for CALCR

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    Uscn ELISAs and CLIAs for CALCR

    Protein Domains /
    Families
    for CALCR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CALCR for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003287 GCPR_2_calcitonin_rcpt_fam
     IPR000832 GPCR_2_secretin-like
     IPR001688 GPCR_2_calcitonin_rcpt
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry P30988

    ProtoNet protein and cluster: P30988

    3 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001688 Calcitonin receptor signature
    IPB003287 Calcitonin receptor family signature


    UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for CALCR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALCR_HUMAN, P30988
    Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding
    protein that is sensitive to cholera toxin

         Genatlas biochemistry entry for CALCR:
    calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for
    osteoporosis,polymorphism associated with bone resorption

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA14722252
    GO:0004948calcitonin receptor activity IEA--
    GO:0005515protein binding IPI7588285
    GO:0008565protein transporter activity IDA14722252
    GO:0032841calcitonin binding IPI8078488
         
    CALCR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALCR:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Calcr):
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging 
     normal  skeleton 

    CALCR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Calcrtm1Dgal for CALCR
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CALCR 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCR
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCR (see all 88):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4254 hsa-miR-200a hsa-miR-605 hsa-miR-1245 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CALCR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCR (see all 7)
    OriGene shRNA RFP: CALCR
    OriGene siRNA: CALCR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCR
    Sirion Biotech Custom design and validation of potent shRNA sequences against CALCR 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CALCR
    Sirion Biotech Customized adenovirus for overexpression of CALCR 
    Sirion Biotech Customized adenovirus for potent knockdown of CALCR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCR (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCR (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCR (NM_001742)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCR 

    Cell Line
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    Search LifeMap BioReagents cell lines for CALCR
    Sirion Biotech Customized stable knockdown cell line services for CALCR 
    Sirion Biotech Customized inducible knockdown cell line services for CALCR
    Sirion Biotech Customized stable overexpressing cell line services for CALCR
    Sirion Biotech Customized inducible overexpressing cell line services for CALCR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCR


    Pathways & Interactions
    for CALCR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Transcription_Role of VDR in regulation of genes involved in osteoporosis
    		Transcription_Role of VDR in regulation of genes involved in osteoporosis1.00
    		Transcription Role of VDR in regulation of genes involved in osteoporosis0.80
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    4G beta:gamma signalling through PLC beta
    		Class B/2 (Secretin family receptors)0.20
    		G alpha (s) signalling events0.14
    5Calcitonin-like ligand receptors
    		Calcitonin-like ligand receptors1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CALCR
        Adenylate cyclase-activating neuropeptides
    Transcription Role of VDR in regulation of genes involved in osteoporosis


    1 GeneGo (Thomson Reuters) Pathway for CALCR
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALCR 
        RANKL/RANK Signaling Pathway
    GPCRs, Class B Secretin-like

    5/7        Reactome Pathways for CALCR (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    Calcitonin-like ligand receptors
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for CALCR):
        Neuroactive ligand-receptor interaction
    Osteoclast differentiation


    CALCR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALCR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for CALCR (P309882, 3 ENSP000003525614) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51639 I2D: score=3 
    CALM3P621582, 3MINT-51639 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51639 I2D: score=3 STRING: ENSP00000349467
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    APOBP041143, ENSP000002332424I2D: score=1 STRING: ENSP00000233242
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway NAS1331173
    GO:0007202NOT activation of phospholipase C activity IDA4961748
    GO:0007204elevation of cytosolic calcium ion concentration IDA8078488
    GO:0015031protein transport IDA14722252

    CALCR for ontologies           About GeneDecksing



    Drugs & Compounds
    for CALCR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALCR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CALCR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CRSP-1Endogenous central CT receptor agonist[697327-12-1]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    SUN-B 8155Non-peptide calcitonin (CT) receptor agonist[345893-91-6]
    CGRP (rat)Potent vasodilator[96827-03-1]

    2 DrugBank Compounds for CALCR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pramlintide-- 151126-32-8targetagonist19273748 15494035 18593822 11772274 20015292 20357016
    Salmon CalcitoninCalcitonin 1 precursor (see all 4)47931-85-1targetagonist3004987 9231703 7610922 11752352

    10/23 Novoseek chemical compound relationships for CALCR gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tartrate 60.7 10 20186669 (1), 2027819 (1), 18378205 (1), 8976638 (1) (see all 6)
    adenylate 55.9 13 9600664 (3), 8388616 (2), 8275550 (1), 7723741 (1) (see all 10)
    cyclic amp 47.8 13 17890110 (3), 9231703 (1), 12630807 (1), 7619207 (1) (see all 9)
    calcitriol 41.8 3 7681783 (2), 1324244 (1)
    1,25 dihydroxy vitamin d3 39.7 1 11760834 (1)
    vitamin d 36.8 22 17028393 (1), 15856322 (1), 16339696 (1), 12016463 (1) (see all 11)
    calcium 33.1 24 8397191 (4), 7884591 (2), 8254582 (2), 19445988 (2) (see all 11)
    forskolin 24.2 1 17890110 (1)
    dexamethasone 21.5 8 11250927 (4), 1655943 (1), 9705072 (1)
    estrogen 20.8 13 16339696 (1), 18769961 (1), 16713399 (1), 19255718 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about CALCR 

    Transcripts
    for CALCR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CALCR gene (3 alternative transcripts): 
    NM_001164737.1  NM_001164738.1  NM_001742.3  

    Unigene Cluster for CALCR:

    Calcitonin receptor
    Hs.489127  [show with all ESTs]
    Unigene Representative Sequence: NM_001164737
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421592 ENST00000394441 ENST00000426151 ENST00000423724 ENST00000415529
    ENST00000359558(uc003umv.2) ENST00000360249(uc003ums.1 uc003umt.1 uc022ahi.1 uc003umw.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCR
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCR (see all 88):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4254 hsa-miR-200a hsa-miR-605 hsa-miR-1245 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CALCR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCR (see all 7)
    OriGene shRNA RFP: CALCR
    OriGene siRNA: CALCR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCR
    Sirion Biotech Custom design and validation of potent shRNA sequences against CALCR 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCR (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCR (NM_001742)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALCR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCR

    Additional cDNA sequence: 

    AB022177.1 AB022178.1 AJ831406.1 AJ831407.1 AK313996.1 AY430048.1 BC069611.1 BC075028.2 
    FN994993.1 FN994994.1 FN994995.1 FN994996.1 L00587.1 U26553.1 U26554.1 X69920.1 
    X82466.1 

    2 DOTS entries:

    DT.310885  DT.121123954 

    19 AceView cDNA sequences:

    AY430048 BX280583 X69920 BC075028 AJ831407 NM_001742 T29239 U26553 
    X82466 AB022177 L00587 BC069611 BM560528 U26554 AB022178 BV206127 
    AA330431 AI401275 AW772176 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CALCR    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                    -                                                                 -                                             
    SP2:                    -     -                                         -                 -                                             
    SP3:                                                                                                                                    
    SP4:                          -                                         -                 -                                             
    SP5:                                                                    -                                                               


    ECgene alternative splicing isoforms for CALCR

    Expression
    for CALCR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALCR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAACAGAG
    CALCR Expression
    About this image

    CALCR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical SomitesCervical Somite CellsSomite
    SomiteLumbar SomitesLumbar Somite CellsSmooth Muscle, Somite
    SomiteSacral SomitesSacral Somite CellsSmooth Muscle, Somite
    SomiteSomitesSomite CellsSmooth Muscle, Somite
    SomiteThoracic SomitesThoracic Somite CellsSmooth Muscle, Somite
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See CALCR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALCR

    SOURCE GeneReport for Unigene cluster: Hs.489127
        SABiosciences Expression via Pathway-Focused PCR Arrays including CALCR: 
              Osteogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat

    Primer
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    Orthologs
    for CALCR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CALCR gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CALCR1 calcitonin receptor 69.07(n)
    64.63(a)    		   428425  XM_425985.3  XP_425985.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CALCR6
    		 --
    		 55(a)
    		 1 ↔ 1
    		 6(21689459-21746567)
    zebrafish
    (Danio rerio)    		 Actinopterygii calcr1 calcitonin receptor 64.66(n)
    63.19(a)    		   560268  XM_003200631.1  XP_003200679.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta EG:BACR25B3.33 G-protein coupled receptor protein signaling
    pathway more    		 28(a)   3A6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea C13B9.43   -- 32(a)   III(6705842-6710584)   --


    ENSEMBL Gene Tree for CALCR (if available)
    TreeFam Gene Tree for CALCR (if available) 

    Paralogs
    for CALCR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALCR gene
    GLP1R2  GHRHR2  GCGR2  CRHR22  PTH1R2  VIPR12  CRHR12  PTH2R2  
    CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  VIPR22  GIPR2  
    16 SIMAP similar genes for CALCR using alignment to 5 protein entries:     CALCR_HUMAN (see all proteins):
    HCTR-5    HCTR-6    CALCRL    CRHR2    VIPR1    CRHR1
    GLP2R    PTH1R    SCTR    PTH2R    VIPR2    GLP1R
    ADCYAP1R1    GCGR    GIPR    GHRHR

    CALCR for paralogs           About GeneDecksing



    Genomic Variants
    for CALCR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988
    Polymorphism: Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor
    for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone
    microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic
    bones are more at risk of fracture


    10/2390 NCBI SNPs in CALCR are shown (see all 2390)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs18011971,2
    		C,F,Hother92385066(-) GGAGCT/CGAGGA 6 /P /L mis1 ese340Minor allele frequency- C:0.45EA MN NA NS WA CSA EU 10346
    rs127046701,2
    		C,F,H--87739584(+) ATGGCC/TACGTC 3 -- int18Minor allele frequency- T:0.05NS EA NA WA 662
    rs1134895801,2
    		C--87809016(+) TTTCGT/-GTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs624668361,2
    		C--92383132(+) TAATAT/CATTTC 3 -- ut312Minor allele frequency- C:0.05NA 122
    rs753431031,2
    		C,F--92383177(+) TTTAAC/TGTACT 3 -- ut311Minor allele frequency- T:0.03WA 118
    rs10421391,2
    		C--92383236(-) TAGTTC/ATGCCC 3 -- ut312Minor allele frequency- A:0.00MN NA 186
    rs783445151,2
    		--92383896(+) ACAAGC/TGGTCA 3 -- ut310--------
    rs38398351,2
    		C--92384140(-) AAAGA-/AAGA  
                GAGTT     		3 -- ut310--------
    rs1998689501,2
    		C--92384192(+) GTTTTG/TTAAAA 3 -- ut310--------
    rs38020541,2
    		C,F,H--92384234(-) GTTTAT/CAAACT 3 -- ut316Minor allele frequency- C:0.03EA NS 2034

    HapMap Linkage Disequilibrium report for CALCR (93053799 - 93204042 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CALCR
         1 CNV: 94693
    Human Gene Mutation Database (HGMD): CALCR

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CALCR

    Disorders / Diseases
    for CALCR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CALCR for disorders           About GeneDecksing

    OMIM gene information: 114131   
    OMIM disorders: 166710  
    20/39 diseases for CALCR (see all 39):    About MalaCards
    osteoporosis    pigmented villonodular synovitis    osteoporosis, postmenopausal, susceptibility    osteoporosis, postmenopausal
    osteopenia/osteoporosis    thyroiditis    villonodular synovitis    iron overload
    beta thalassemia    juvenile rheumatoid arthritis    ovarian small cell carcinoma    giant cell tumor
    hypercalcemia    hemolytic anemia    rheumatoid arthritis    small cell carcinoma
    wilson disease    thalassemia    williams syndrome    nephrolithiasis

    10/21 Novoseek disease relationships for CALCR gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoclastoma 62.2 3 7884591 (2)
    osteoporosis 47.1 4 16363366 (2), 12016463 (1), 19255718 (1)
    osteopenia 45.2 1 16363366 (1)
    central giant cell granuloma 43.5 1 16580179 (1)
    thyroid carcinoma medullary 37.7 4 9510122 (1), 8143880 (1)
    hypercalcemia 36 3 2363727 (1), 11250927 (1), 7789182 (1)
    carcinoma medullary 34 1 8143880 (1)
    bone loss 27.7 5 11136533 (2), 11858573 (1), 16675892 (1)
    urinary stones 12.8 2 15856322 (1), 11464063 (1)
    breast carcinoma 7.58 4 14965723 (2), 1322087 (1), 9487987 (1)

    Genetic Association Database (GAD): CALCR
    Human Genome Epidemiology (HuGE) Navigator: CALCR (34 documents)

    Export disorders for CALCR gene to outside databases

    Publications
    for CALCR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALCR gene, integrated from 9 sources (see all 288):
    (articles sorted by number of sources associating them with CALCR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. (PubMed id 9817931)1, 2, 4, 9 Taboulet J....de Vernejoul M.-C. (1998)
    2. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PubMed id 1331173)1, 2, 3, 9 Gorn A.H.... Goldring S.R. (1992)
    3. Association of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal women. (PubMed id 11136533)1, 4, 9 Braga V....Adami S. (2000)
    4. Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor. (PubMed id 7720653)1, 2, 9 Nussenzveig D.R.... Gershengorn M.C. (1995)
    5. Association between bone mineral density and polymorphisms of the VDR, ERalpha, COL1A1 and CTR genes in Spanish postmenopausal women. (PubMed id 15966503)1, 4, 9 Bandres E....Garcia-Foncillas J. (2005)
    6. [Association of calcitonin receptor gene polymorphism with bone mineral density in Shanghai women] (PubMed id 12905735)1, 4, 9 Zhao H.Y....Chen J.L. (2003)
    7. Relationship among VDR (BsmI and FokI), COLIA1, and CTR polymorphisms with bone mass, bone turnover markers, and sex hormones in men. (PubMed id 12016463)1, 4, 9 Braga V....Adami S. (2002)
    8. Association of low bone mass with vitamin d receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis. (PubMed id 12375338)1, 4, 9 Masi L....Falcini F. (2002)
    9. Calcitonin receptor gene polymorphism in japanese women: correlation with body mass and bone mineral density. (PubMed id 11353946)1, 4, 9 Nakamura M....Kakudo K. (2001)
    10. A novel calcitonin receptor gene in human osteoclasts from normal bone marrow. (PubMed id 10570950)1, 2, 9 Nishikawa T.... Koshihara Y. (1999)

    External Searches for CALCR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CALCR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 799 HGNC: 1440 AceView: CALCR Ensembl:ENSG00000004948 euGenes: HUgn799
    ECgene: CALCR Kegg: 799 H-InvDB: CALCR

    Other Databases showing CALCR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CALCR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALCR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CALCR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CALCR gene:
    Search GeneIP for patents involving CALCR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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