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CALCR Gene

protein-coding   GIFtS: 69
GCID: GC07M093053

Calcitonin Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcitonin Receptor1 2
CT-R2 3
CRT2 5
CTR2
CTR12

External Ids:    HGNC: 14401   Entrez Gene: 7992   Ensembl: ENSG000000049487   OMIM: 1141315   UniProtKB: P309883   

Export aliases for CALCR gene to outside databases

Previous GC identifers: GC07M091589 GC07M092652 GC07M092665 GC07M092698 GC07M092891 GC07M087664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALCR Gene:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven
transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium
homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been
associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for CALCR Gene:
CALCR (calcitonin receptor) is a protein-coding gene. Diseases associated with CALCR include osteoporosis, postmenopausal, susceptibility, and ovarian small cell carcinoma. GO annotations related to this gene include calcitonin receptor activity and receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988
Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which
activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine
triphosphate-binding protein that is sensitive to cholera toxin

summary for CALCR Gene:
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight
subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;
high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels
present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit
bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT
receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II
diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form
the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main
function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCR (Calcitonin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCR gene promoter:
         HOXA9B   HOXA9   POU3F2 (N-Oct-5a)   Meis-1a   POU3F2 (N-Oct-5b)   POU3F2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CALCR promoter sequence
   Search Chromatin IP Primers for CALCR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

CALCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M093053:  view genomic region     (about GC identifiers)

Start:
93,053,799 bp from pter      End:
93,204,042 bp from pter
Size:
150,244 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 92,383,112-92,533,218     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988 (See protein sequence)
Recommended Name: Calcitonin receptor precursor  
Size: 508 amino acids; 59352 Da
Subunit: Interacts with GPRASP2
Sequence caution: Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: F5H605 O14585 Q13941 Q5ZGL8 Q659U6 Q6DJU8 Q6T712
Alternative promoter usage, Alternative splicing: 6 isoforms:  P30988-1   P30988-2   P30988-3   P30988-4   P30988-5   P30988-6   

Explore the universe of human proteins at neXtProt for CALCR: NX_P30988

Explore proteomics data for CALCR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn91, Asn143, Asn148
  • Modification sites at PhosphoSitePlus

  • See CALCR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158209.1  NP_001158210.1  NP_001733.1  

    ENSEMBL proteins: 
     ENSP00000399552   ENSP00000377959   ENSP00000389295   ENSP00000391369   ENSP00000413179  
     ENSP00000352561   ENSP00000353385  
    Reactome Protein details: P30988

    CALCR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CALCR Protein
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate for CALCR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CALCR
    GenScript Custom Purified and Recombinant Proteins Services for CALCR
    Novus Biologicals CALCR Proteins
    Novus Biologicals CALCR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CALCR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CALCR (Calcitonin R)
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    OriGene Custom Antibody Services for CALCR
    Novus Biologicals CALCR Antibodies
    Abcam antibodies for CALCR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CALCR
    LSBio Antibodies in human, mouse, rat for CALCR

    CALCR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CALCR: GPCR / Class B : Calcitonin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CT receptor
    Calcitonin receptors

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003287 GCPR_2_calcitonin_rcpt_fam
     IPR000832 GPCR_2_secretin-like
     IPR001688 GPCR_2_calcitonin_rcpt
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry P30988

    ProtoNet protein and cluster: P30988

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001688 Calcitonin receptor signature
    IPB003287 Calcitonin receptor family signature


    UniProtKB/Swiss-Prot: CALCR_HUMAN, P30988
    Similarity: Belongs to the G-protein coupled receptor 2 family


    CALCR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALCR_HUMAN, P30988
    Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine
    triphosphate-binding protein that is sensitive to cholera toxin

         Genatlas biochemistry entry for CALCR:
    calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for
    osteoporosis,polymorphism associated with bone resorption

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA10882736
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004948calcitonin receptor activity IEA--
    GO:0005515protein binding IPI14722252
         
    CALCR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALCR:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Calcr):
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging 
     normal  skeleton 

    CALCR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calcrtm1Dgal for CALCR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALCR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALCR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CALCR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCR (see all 88):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4254 hsa-miR-200a hsa-miR-605 hsa-miR-1245 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCALCR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALCR
    Predesigned siRNA for gene silencing in human, mouse, rat CALCR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALCR

    Clone
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    OriGene clones in human, mouse for CALCR (see all 15)
    OriGene ORF clones in mouse, rat for CALCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCR (NM_001742)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCR

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CALCR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALCR_HUMAN, P30988: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS7588285
    GO:0005929cilium ----
    GO:0016020membrane ----

    CALCR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALCR About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    4RANK Signaling in Osteoclasts
    RANKL/RANK Signaling Pathway0.31
    5Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CALCR
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALCR
        GPCRs, Class B Secretin-like
    RANKL/RANK Signaling Pathway

    2 Reactome Pathways for CALCR
        Calcitonin-like ligand receptors
    G alpha (s) signalling events


    2 Kegg Pathways  (Kegg details for CALCR):
        Neuroactive ligand-receptor interaction
    Osteoclast differentiation


    CALCR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCR: 
              Osteogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CALCR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALCR (P309882, 3 ENSP000003525614) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51639 I2D: score=3 
    CALM3P621582, 3MINT-51639 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51639 I2D: score=3 STRING: ENSP00000349467
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    APOBP041143, ENSP000002332424I2D: score=1 STRING: ENSP00000233242
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway IDA7588285
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway NAS1331173
    GO:0007190NOT activation of adenylate cyclase activity IDA15563840

    CALCR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CALCR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    2 DrugBank Compounds for CALCR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pramlintide-- 151126-32-8targetagonist19273748 15494035 18593822 11772274 20015292 20357016
    Salmon CalcitoninCalcitonin 1 precursor (see all 4)47931-85-1targetagonist3004987 9231703 7610922 11752352

    Selected IUPHAR Ligands for CALCR (CT receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    calcitonin
    AgonistFull agonist9 - 11.215692146 12565884 7588285 11023820 11033437 10342886
    CT (salmon)
    AgonistFull agonist7.6 - 11.18828514 7588285 7769107 14623894
    [125I]CT (human)
    AgonistFull agonist9 - 10--
    [125I]CT (salmon)
    AgonistFull agonist10--
    amylin
    AgonistFull agonist7 - 9.515692146 9487987 11033437
    amylin
    AgonistFull agonist8 - 9.210342886 9487987
    CT-(8-32) (salmon)
    AntagonistAntagonist910856900
    alpha-CGRP
    AgonistFull agonist6.2 - 8.415692146 9487987 14722252 11023820
    adrenomedullin
    AgonistFull agonist6.7 - 7.715692146 12565884
    beta-CGRP
    AgonistFull agonist7.215692146

    Selected Novoseek inferred chemical compound relationships for CALCR gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tartrate 60.7 10 20186669 (1), 2027819 (1), 18378205 (1), 8976638 (1) (see all 6)
    adenylate 55.9 13 9600664 (3), 8388616 (2), 8275550 (1), 7723741 (1) (see all 10)
    cyclic amp 47.8 13 17890110 (3), 9231703 (1), 12630807 (1), 7619207 (1) (see all 9)
    calcitriol 41.8 3 7681783 (2), 1324244 (1)
    1,25 dihydroxy vitamin d3 39.7 1 11760834 (1)
    vitamin d 36.8 22 17028393 (1), 15856322 (1), 16339696 (1), 12016463 (1) (see all 11)
    calcium 33.1 24 8397191 (4), 7884591 (2), 8254582 (2), 19445988 (2) (see all 11)
    forskolin 24.2 1 17890110 (1)
    dexamethasone 21.5 8 11250927 (4), 1655943 (1), 9705072 (1)
    estrogen 20.8 13 16339696 (1), 18769961 (1), 16713399 (1), 19255718 (1) (see all 7)



    CALCR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CALCR gene (3 alternative transcripts): 
    NM_001164737.1  NM_001164738.1  NM_001742.3  

    Unigene Cluster for CALCR:

    Calcitonin receptor
    Hs.489127  [show with all ESTs]
    Unigene Representative Sequence: NM_001164737
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421592 ENST00000394441 ENST00000426151 ENST00000423724 ENST00000415529
    ENST00000359558(uc003umv.2) ENST00000360249(uc003ums.1 uc003umt.1 uc022ahi.1 uc003umw.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CALCR (see all 88):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4254 hsa-miR-200a hsa-miR-605 hsa-miR-1245 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCALCR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CALCR
    Clone
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    OriGene ORF clones in mouse, rat for CALCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCR (NM_001742)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALCR
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCR
      QuantiTect SYBR Green Assays in human, mouse, rat CALCR
      QuantiFast Probe-based Assays in human, mouse, rat CALCR

    Additional mRNA sequence: 

    AB022177.1 AB022178.1 AJ831406.1 AJ831407.1 AK313996.1 AY430048.1 BC069611.1 BC075028.2 
    FN994993.1 FN994994.1 FN994995.1 FN994996.1 L00587.1 U26553.1 U26554.1 X69920.1 
    X82466.1 

    2 DOTS entries:

    DT.310885  DT.121123954 

    19 AceView cDNA sequences:

    NM_001742 BC075028 AJ831407 T29239 AY430048 BX280583 X69920 AA330431 
    BM560528 BC069611 X82466 AB022178 L00587 AB022177 BV206127 U26554 
    U26553 AW772176 AI401275 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CALCR    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                    -                                                                 -                                             
    SP2:                    -     -                                         -                 -                                             
    SP3:                                                                                                                                    
    SP4:                          -                                         -                 -                                             
    SP5:                                                                    -                                                               


    ECgene alternative splicing isoforms for CALCR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALCR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACAGAG
    CALCR Expression
    About this image


    CALCR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
     
     Somite (Muscoskeletal System)    fully expand to see all 5 entries
             Sacral Somite Cells Sacral Somite
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Ureteric Bud
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    CALCR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALCR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489127
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCR: 
              Osteogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CALCR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcr1 , 5 calcitonin receptor1, 5 78.91(n)1
    77.8(a)1
      6 (1.81 cM)5
    123111  NM_007588.21  NP_031614.21 
     36856775 
    chicken
    (Gallus gallus)
    Aves CALCR1 calcitonin receptor 68.82(n)
    64.3(a)
      428425  XM_425985.4  XP_425985.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    60(a)
    many ↔ many
    6(21687847-21828657)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia calcr1 calcitonin receptor 66.14(n)
    62.98(a)
      100491101  XM_002934599.2  XP_002934645.2 
    zebrafish
    (Danio rerio)
    Actinopterygii calcr1 calcitonin receptor 64.45(n)
    62.84(a)
      560268  XM_003200631.2  XP_003200679.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:BACR25B3.33 G-protein coupled receptor protein
    signaling pathway more
    28(a)   3A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea C13B9.43   -- 32(a)   III(6705842-6710584)   --


    ENSEMBL Gene Tree for CALCR (if available)
    TreeFam Gene Tree for CALCR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALCR gene
    GLP1R2  GHRHR2  GCGR2  PTH1R2  CRHR22  VIPR12  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for CALCR using alignment to 4 protein entries:     CALCR_HUMAN (see all proteins):
    CALCRL    CRHR2    VIPR1    GLP2R    PTH1R    SCTR
    CRHR1    GLP1R    PTH2R    VIPR2    ADCYAP1R1    GCGR
    GIPR

    CALCR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CALCR_HUMAN, P30988: Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk
    factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of
    bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone.
    Osteoporotic bones are more at risk of fracture


    Selected SNPs for CALCR (see all 2815)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18011971,2,,4
    C,F,Hother196362415(-) GGAGCT/CGAGGA 6 /P /L mis1 ese340Minor allele frequency- C:0.45EA MN NA NS WA CSA EU 10346
    rs132244771,2
    A--87670094(+) TttttG/Ttttgt 3 -- int10--------
    rs2019104371,2
    C--92413242(+) TAGAAA/CAAAAA 3 -- int10--------
    rs40152731,2
    C--92413582(+) tgtgt-/GT    
       
    /GTGT
    NNNTT
    3 -- int11NA 2
    rs105509571,2
    C--92419192(+) aaaaa-/AAAAA 
            
    aaaaa
    3 -- int11Minor allele frequency- AAAAA:0.00NA 2
    rs2017651121,2
    C--92427955(+) TAATTC/TTTTTT 3 -- int10--------
    rs583827621,2
    C--92442150(+) ATATA-/AT/TA 
            
    ATTAC
    3 -- int10--------
    rs786527211,2
    C--92445701(+) TTTCA-/TTTTTT 3 -- int10--------
    rs32141441,2
    C--92445707(+) TTTTTT/-CTATT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs107194201,2
    C--92446585(+) AGATTC/-TCCAA 3 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for CALCR (93053799 - 93204042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CALCR (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666561CNV Deletion23128226
    esv999961CNV Deletion20482838
    esv2734824CNV Deletion23290073
    esv2734823CNV Deletion23290073
    esv2676719CNV Deletion23128226
    esv2667635CNV Deletion23128226
    nsv5846CNV Insertion18451855
    esv272958CNV Insertion20981092
    esv270500CNV Insertion20981092
    nsv888737CNV Loss21882294

    Human Gene Mutation Database (HGMD): CALCR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCR
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114131   
    OMIM disorders: 166710  
    Selected diseases for CALCR (see all 39):    
    About MalaCards
    osteoporosis, postmenopausal, susceptibility    ovarian small cell carcinoma    osteoporosis    villonodular synovitis
    pigmented villonodular synovitis    synovitis    osteoporotic fracture    small cell carcinoma
    wilson disease    hypercalcemia    giant cell tumor    beta thalassemia
    juvenile rheumatoid arthritis    nephrolithiasis    thalassemia    thyroiditis
    hemolytic anemia    hyperparathyroidism    lung cancer    cholera

    1 disease from the University of Copenhagen DISEASES database for CALCR:
    Osteoporosis

    CALCR for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CALCR gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoclastoma 62.2 3 7884591 (2)
    osteoporosis 47.1 4 16363366 (2), 12016463 (1), 19255718 (1)
    osteopenia 45.2 1 16363366 (1)
    central giant cell granuloma 43.5 1 16580179 (1)
    thyroid carcinoma medullary 37.7 4 9510122 (1), 8143880 (1)
    hypercalcemia 36 3 2363727 (1), 11250927 (1), 7789182 (1)
    carcinoma medullary 34 1 8143880 (1)
    bone loss 27.7 5 11136533 (2), 11858573 (1), 16675892 (1)
    urinary stones 12.8 2 15856322 (1), 11464063 (1)
    breast carcinoma 7.58 4 14965723 (2), 1322087 (1), 9487987 (1)

    Genetic Association Database (GAD): CALCR
    Human Genome Epidemiology (HuGE) Navigator: CALCR (34 documents)

    Export disorders for CALCR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALCR gene, integrated from 10 sources (see all 295):
    (articles sorted by number of sources associating them with CALCR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. (PubMed id 9817931)1, 2, 4, 9 Taboulet J....de Vernejoul M.-C. (Hum. Mol. Genet. 1998)
    2. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PubMed id 1331173)1, 2, 3, 9 Gorn A.H.... Goldring S.R. (J. Clin. Invest. 1992)
    3. Association of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal women. (PubMed id 11136533)1, 4, 9 Braga V....Adami S. (Calcif. Tissue Int. 2000)
    4. Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor. (PubMed id 7720653)1, 2, 9 Nussenzveig D.R.... Gershengorn M.C. (Endocrinology 1995)
    5. Association between bone mineral density and polymorphisms of the VDR, ERalpha, COL1A1 and CTR genes in Spanish postmenopausal women. (PubMed id 15966503)1, 4, 9 BandrAcs E....GarcA-a-Foncillas J. (J. Endocrinol. Invest. 2005)
    6. [Association of calcitonin receptor gene polymorphism with bone mineral density in Shanghai women]. (PubMed id 12905735)1, 4, 9 Zhao H.Y....Chen J.L. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003)
    7. Relationship among VDR (BsmI and FokI), COLIA1, and CTR polymorphisms with bone mass, bone turnover markers, and sex hormones in men. (PubMed id 12016463)1, 4, 9 Braga V....Adami S. (Calcif. Tissue Int. 2002)
    8. Association of low bone mass with vitamin d receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis. (PubMed id 12375338)1, 4, 9 Masi L....Falcini F. (J. Rheumatol. 2002)
    9. Calcitonin receptor gene polymorphism in japanese women: correlation with body mass and bone mineral density. (PubMed id 11353946)1, 4, 9 Nakamura M....Kakudo K. (Calcif. Tissue Int. 2001)
    10. A novel calcitonin receptor gene in human osteoclasts from normal bone marrow. (PubMed id 10570950)1, 2, 9 Nishikawa T.... Koshihara Y. (FEBS Lett. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 799 HGNC: 1440 AceView: CALCR Ensembl:ENSG00000004948 euGenes: HUgn799
    ECgene: CALCR Kegg: 799 H-InvDB: CALCR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALCR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALCR gene:
    Search GeneIP for patents involving CALCR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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