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Aliases for CALCR Gene

Aliases for CALCR Gene

  • Calcitonin Receptor 2 3 5
  • CT-R 3 4
  • CTR1 3
  • CRT 3
  • CTR 3

External Ids for CALCR Gene

Previous GeneCards Identifiers for CALCR Gene

  • GC07M091589
  • GC07M092652
  • GC07M092665
  • GC07M092698
  • GC07M092891
  • GC07M093053
  • GC07M087664

Summaries for CALCR Gene

Entrez Gene Summary for CALCR Gene

  • This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for CALCR Gene

CALCR (Calcitonin Receptor) is a Protein Coding gene. Diseases associated with CALCR include Osteoporosis and Pigmented Villonodular Synovitis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is CALCRL.

UniProtKB/Swiss-Prot for CALCR Gene

  • This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Tocris Summary for CALCR Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCR Gene

Genomics for CALCR Gene

Regulatory Elements for CALCR Gene

Enhancers for CALCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CALCR on UCSC Golden Path with GeneCards custom track

Genomic Location for CALCR Gene

Chromosome:
7
Start:
93,424,487 bp from pter
End:
93,574,730 bp from pter
Size:
150,244 bases
Orientation:
Minus strand

Genomic View for CALCR Gene

Genes around CALCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCR Gene

Proteins for CALCR Gene

  • Protein details for CALCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30988-CALCR_HUMAN
    Recommended name:
    Calcitonin receptor
    Protein Accession:
    P30988
    Secondary Accessions:
    • A4D1G6
    • F5H605
    • O14585
    • Q13941
    • Q5ZGL8
    • Q659U6
    • Q6DJU8
    • Q6T712

    Protein attributes for CALCR Gene

    Size:
    508 amino acids
    Molecular mass:
    59352 Da
    Quaternary structure:
    • Interacts with GPRASP2.
    SequenceCaution:
    • Sequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCR Gene

    Alternative splice isoforms for CALCR Gene

neXtProt entry for CALCR Gene

Post-translational modifications for CALCR Gene

  • Glycosylation at Asn 46, Asn 91, Asn 143, and Asn 148
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CALCR Gene

Domains & Families for CALCR Gene

Gene Families for CALCR Gene

Suggested Antigen Peptide Sequences for CALCR Gene

Graphical View of Domain Structure for InterPro Entry

P30988

UniProtKB/Swiss-Prot:

CALCR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCR: view

Function for CALCR Gene

Molecular function for CALCR Gene

GENATLAS Biochemistry:
calcitonin receptor,G protein coupled receptor superfamily,including 3 isoforms,candidate gene for osteoporosis,polymorphism associated with bone resorption
UniProtKB/Swiss-Prot Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Gene Ontology (GO) - Molecular Function for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0004948 calcitonin receptor activity IEA --
GO:0005515 protein binding IPI 7588285
GO:0008565 protein transporter activity IDA 14722252
GO:0032841 calcitonin binding IPI 15563840
genes like me logo Genes that share ontologies with CALCR: view
genes like me logo Genes that share phenotypes with CALCR: view

Animal Models for CALCR Gene

MGI Knock Outs for CALCR:

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCR

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CALCR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCR Gene

Localization for CALCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCR Gene COMPARTMENTS Subcellular localization image for CALCR gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7588285
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with CALCR: view

Pathways & Interactions for CALCR Gene

genes like me logo Genes that share pathways with CALCR: view

Gene Ontology (GO) - Biological Process for CALCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,NAS 1331173
GO:0007190 NOT activation of adenylate cyclase activity IDA 15563840
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0015031 protein transport IDA 14722252
genes like me logo Genes that share ontologies with CALCR: view

No data available for SIGNOR curated interactions for CALCR Gene

Drugs & Compounds for CALCR Gene

(35) Drugs for CALCR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43
Salmon Calcitonin Approved, Investigational Pharma binder, Target, agonist 92
amylin Pharma Full agonist, Agonist 0
AC 187 Pharma Amylin receptor antagonist, Potent and selective, Potent and selective amylin receptor antagonist 0
[<sup>125</sup>I]CT (human) Pharma Full agonist, Agonist 0

(15) Additional Compounds for CALCR Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP
Full agonist, Agonist
beta-CGRP
Full agonist, Agonist
CT (salmon)
Full agonist, Agonist
alpha-CGRP (human)
90954-53-3
BIBN 4096
204697-65-4

(5) Tocris Compounds for CALCR Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist 151804-77-2
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
BIBN 4096 Potent and selective CGRP receptor antagonist 204697-65-4
CGRP (rat) Potent vasodilator 83651-90-5
CGRP 8-37 (rat) CGRP1 receptor antagonist 129121-73-9

(8) ApexBio Compounds for CALCR Gene

Compound Action Cas Number
AC 187 Amylin receptor antagonist, Potent and selective 151804-77-2
Amylin 122384-88-7
CGRP 8-37 (human) 119911-68-1
CRSP-1 697327-12-1
PHM 27 (human) 118025-43-7
SB 268262 217438-17-0
SUN-B 8155 345893-91-6
α-CGRP (human) 90954-53-3
genes like me logo Genes that share compounds with CALCR: view

Transcripts for CALCR Gene

mRNA/cDNA for CALCR Gene

Unigene Clusters for CALCR Gene

Calcitonin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CALCR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: - - - -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CALCR Gene

GeneLoc Exon Structure for
CALCR
ECgene alternative splicing isoforms for
CALCR

Expression for CALCR Gene

mRNA expression in normal human tissues for CALCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCR Gene

This gene is overexpressed in Brain - Hypothalamus (x26.3).

Protein differential expression in normal tissues from HIPED for CALCR Gene

This gene is overexpressed in Nasal epithelium (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALCR Gene



Protein tissue co-expression partners for CALCR Gene

NURSA nuclear receptor signaling pathways regulating expression of CALCR Gene:

CALCR

SOURCE GeneReport for Unigene cluster for CALCR Gene:

Hs.489127
genes like me logo Genes that share expression patterns with CALCR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CALCR Gene

Orthologs for CALCR Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALCR 34
  • 76.04 (n)
  • 70.62 (a)
CALCR 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCR 34
  • 88.89 (n)
  • 90.08 (a)
CT-R 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcr 34
  • 78.91 (n)
  • 77.8 (a)
Calcr 16
Calcr 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALCR 34
  • 99.48 (n)
  • 99.41 (a)
CALCR 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calcr 34
  • 78.98 (n)
  • 80.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CALCR 34
  • 68.82 (n)
  • 64.3 (a)
-- 35
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia calcr 34
  • 66.14 (n)
  • 62.98 (a)
zebrafish
(Danio rerio)
Actinopterygii calcr 34
  • 64.45 (n)
  • 62.84 (a)
CABZ01088025.1 35
  • 49 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 36
  • 28 (a)
Dh31-R1 35
  • 31 (a)
ManyToMany
hec 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C13B9.4 36
  • 32 (a)
pdfr-1 35
  • 22 (a)
OneToMany
Species where no ortholog for CALCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCR Gene

ENSEMBL:
Gene Tree for CALCR (if available)
TreeFam:
Gene Tree for CALCR (if available)

Paralogs for CALCR Gene

(13) SIMAP similar genes for CALCR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCR: view

Variants for CALCR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CALCR Gene

CALCR_HUMAN-P30988
Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Sequence variations from dbSNP and Humsavar for CALCR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1801197 - 93,426,441(-) GGAGC(C/T)GAGGA reference, missense
rs2106731 -- 93,513,643(+) ACCTT(C/G)GAAAA intron-variant
rs2106735 -- 93,441,499(+) ACATA(C/T)GGATG intron-variant
rs2106736 -- 93,467,578(+) TTTTG(A/C)GGTAA intron-variant
rs2158045 -- 93,453,396(+) AAGAG(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCR Gene

Variant ID Type Subtype PubMed ID
esv2666561 CNV deletion 23128226
esv2667635 CNV deletion 23128226
esv2676719 CNV deletion 23128226
esv2734823 CNV deletion 23290073
esv2734824 CNV deletion 23290073
esv3306223 CNV mobile element insertion 20981092
esv3308685 CNV mobile element insertion 20981092
esv3340276 CNV insertion 20981092
esv3542093 CNV deletion 23714750
esv3614160 CNV loss 21293372
esv3614161 CNV loss 21293372
esv3614163 CNV loss 21293372
esv999961 CNV deletion 20482838
nsv1137266 CNV deletion 24896259
nsv464641 CNV gain 19166990
nsv470380 CNV gain 18288195
nsv5846 CNV insertion 18451855
nsv607815 CNV loss 21841781
nsv607816 CNV gain 21841781
nsv951374 CNV deletion 24416366
nsv958426 CNV deletion 24416366

Variation tolerance for CALCR Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCR Gene

Human Gene Mutation Database (HGMD)
CALCR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCR

Disorders for CALCR Gene

MalaCards: The human disease database

(5) MalaCards diseases for CALCR Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
pigmented villonodular synovitis
  • testicular germ cell tumor
giant cell tumor
  • giant cell neoplasm
maxillary sinus cancer
  • malignant neoplasm of antrum
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
- elite association - COSMIC cancer census association via MalaCards
Search CALCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCR

Genetic Association Database (GAD)
CALCR
Human Genome Epidemiology (HuGE) Navigator
CALCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCR
genes like me logo Genes that share disorders with CALCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCR Gene

Publications for CALCR Gene

  1. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women. (PMID: 9817931) Taboulet J. … de Vernejoul M.-C. (Hum. Mol. Genet. 1998) 3 4 22 46 65
  2. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (PMID: 1331173) Gorn A.H. … Goldring S.R. (J. Clin. Invest. 1992) 2 3 4 22 65
  3. Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. (PMID: 19255718) Musumeci M. … Musumeci S. (J. Bone Miner. Metab. 2009) 3 22 46 65
  4. Lack of association between vitamin D and calcitonin receptor gene polymorphisms and forearm bone values of young Greek males. (PMID: 18622089) Charopoulos I. … Lyritis G.P. (J Musculoskelet Neuronal Interact 2008) 3 22 46 65
  5. Association between an AluI polymorphism in the calcitonin receptor gene and quantitative ultrasound parameters in Korean men. (PMID: 17709929) Kang B.Y. … Lee K.O. (Med Princ Pract 2007) 3 22 46 65

Products for CALCR Gene

Sources for CALCR Gene

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