Aliases for CALCOCO2 Gene
External Ids for CALCOCO2 Gene
Previous GeneCards Identifiers for CALCOCO2 Gene
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for CALCOCO2 Gene
CALCOCO2 (Calcium Binding And Coiled-Coil Domain 2) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TAX1BP1.
UniProtKB/Swiss-Prot for CALCOCO2 Gene
May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.