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CALCOCO1 Gene

protein-coding   GIFtS: 53
GCID: GC12M054105

Calcium Binding And Coiled-Coil Domain 1

  Search for CALCOCO1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding And Coiled-Coil Domain 11 2     Cocoa2
Coiled-Coil Leucine Zipper Coactivator 11 2     Calcium-Binding And Coiled-Coil Domain-Containing Protein 12
Inorganic Pyrophosphatase Activator1 2     calphoglin2
Coiled-Coil Coactivator Protein2 3     Calphoglin3
Sarcoma Antigen NY-SAR-32 3     KIAA15363

External Ids:    HGNC: 293061   Entrez Gene: 576582   Ensembl: ENSG000000128227   UniProtKB: Q9P1Z23   

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALCOCO1 Gene:
CALCOCO1 (calcium binding and coiled-coil domain 1) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
utilization of two different activation regions (By similarity)
Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
growth

Gene Wiki entry for CALCOCO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   Gfi-1   HNF-4alpha1   Pax-3   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCOCO1 promoter sequence
   Search Chromatin IP Primers for CALCOCO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCOCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054105:  view genomic region     (about GC identifiers)

Start:
54,104,902 bp from pter      End:
54,121,529 bp from pter
Size:
16,628 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CALCOCO1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)
Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1  
Size: 691 amino acids; 77336 Da
Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of
GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By
similarity)
Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;
Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090
Alternative splicing: 4 isoforms:  Q9P1Z2-1   Q9P1Z2-2   Q9P1Z2-3   Q9P1Z2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Explore proteomics data for CALCOCO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALCOCO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137154.1  NP_065949.1  

    ENSEMBL proteins: 
     ENSP00000456437   ENSP00000397189   ENSP00000262059   ENSP00000447647   ENSP00000449960  
     ENSP00000450083   ENSP00000448621   ENSP00000447117   ENSP00000449058   ENSP00000446820  
     ENSP00000448026   ENSP00000450012   ENSP00000449796  

    CALCOCO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALCOCO1
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    OriGene MassSpec for CALCOCO1
    OriGene Custom Protein Services for CALCOCO1
    GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
    Novus Biologicals CALCOCO1 Protein
    Novus Biologicals CALCOCO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALCOCO1

     
    Search eBioscience for Proteins for CALCOCO1 

    CALCOCO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CALCOCO1
    Novus Biologicals CALCOCO1 Antibodies
    Abcam antibodies for CALCOCO1
    Cloud-Clone Corp. Antibodies for CALCOCO1
    ThermoFisher Antibodies for CALCOCO1
    LSBio Antibodies in human, mouse, rat for CALCOCO1

    CALCOCO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CALCOCO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALCOCO1
    Cloud-Clone Corp. CLIAs for CALCOCO1
    Search eBioscience for ELISAs for CALCOCO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q9P1Z2

    ProtoNet protein and cluster: Q9P1Z2

    1 Blocks protein domain: IPB012852 Coiled-coil transcriptional coactivator-like

    UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for
    coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)
    Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of
    LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic
    cooperation (By similarity)
    Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160
    coactivators (By similarity)
    Similarity: Belongs to the CALCOCO family


    Find genes that share domains with CALCOCO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACO1_HUMAN, Q9P1Z2
    Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
    through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
    or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
    proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
    Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
    interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
    utilization of two different activation regions (By similarity)
    Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
    component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
    metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
    growth

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003712transcription cofactor activity IDA16344550
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI16344550
    GO:0008013beta-catenin binding IPI16344550
         
    Find genes that share ontologies with CALCOCO1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Calcoco1 (no phenotypes)

    Find genes that share phenotypes with CALCOCO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Calcoco1tm1Lex for CALCOCO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALCOCO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALCOCO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCOCO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCOCO1

    miRNA
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    Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALCOCO1
    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    Sino Biological Human cDNA Clone for CALCOCO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CALCOCO1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CACO1_HUMAN, Q9P1Z2: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CALCOCO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALCOCO1
    Interactions:

        GeneGlobe Interaction Network for CALCOCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CALCOCO1 (Q9P1Z22, 3 ENSP000002620594) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ISS--
    GO:0007165signal transduction ISS--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-templated IMP16344550

    Find genes that share ontologies with CALCOCO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALCOCO1 (CACO1)

    1 HMDB Compound for CALCOCO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts): 
    NM_001143682.1  NM_020898.2  

    Unigene Cluster for CALCOCO1:

    Calcium binding and coiled-coil domain 1
    Hs.156667  [show with all ESTs]
    Unigene Representative Sequence: AF370415
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)
    ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)
    ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619
    ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177
    ENST00000552623 ENST00000549349
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALCOCO1
    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1
    Clone
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    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1
    Primer
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    OriGene qPCR primer pairs and template standards for CALCOCO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCOCO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCOCO1
      QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
      QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

    Additional mRNA sequence: 

    AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1 
    AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1 
    CR533567.1 NR_026554.1 

    24 DOTS entries:

    DT.95304157  DT.417860  DT.95237851  DT.40296235  DT.91758204  DT.121124009  DT.100828568  DT.100828563 
    DT.100828566  DT.91710713  DT.95237849  DT.121123986  DT.121124011  DT.121124014  DT.91758207  DT.91758212 
    DT.91758213  DT.95228852  DT.100828572  DT.121123989  DT.91758216  DT.99969194  DT.100828561  DT.121123975 

    Selected AceView cDNA sequences (see all 397):

    CA445783 BM467220 AI693806 BQ004571 CA439740 CB141179 AI625296 AI143576 
    BQ072576 AW513707 BM711961 BG423110 BU557143 BQ026889 AI347694 CD365444 
    BQ007149 BP335596 AW468451 BP357445 AI216118 AA486443 T17140 BQ954329 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                      -     -     -                             -                             -                       -                 -   
    SP2:                                                                                -                             -                       -                 -   
    SP3:                                      -     -     -                             -     -     -     -     -     -                       -                 -   
    SP4:                                      -     -     -                             -     -     -                 -                       -                 -   
    SP5:                                                                                -                             -                       -                 -   

    ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                      -         
    SP2:                                                                                      -         
    SP3:                                                                                      -         
    SP4:  -     -     -                                                                       -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CALCOCO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALCOCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGAAATA
    CALCOCO1 Expression
    About this image


    CALCOCO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CALCOCO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALCOCO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156667
        Custom PCR Arrays for CALCOCO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALCOCO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCOCO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCOCO1
    QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
    QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CALCOCO1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcoco11 , 5 calcium binding and coiled coil domain 11, 5 87.94(n)1
    89.29(a)1
      15 (57.81 cM)5
    674881  NM_026192.31  NP_080468.11 
     1027067795 
    lizard
    (Anolis carolinensis)
    Reptilia CALCOCO16
    calcium binding and coiled-coil domain 1
    53(a)
    1 ↔ 1
    2(72772605-72806632)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981952 nuclear domain-10 protein NDP52 72.1(n)    AF312719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC051625.12   -- 75.69(n)   386968  BC051625.1 


    ENSEMBL Gene Tree for CALCOCO1 (if available)
    TreeFam Gene Tree for CALCOCO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CALCOCO1 gene
    CALCOCO22  TAX1BP12  
    3 SIMAP similar genes for CALCOCO1 using alignment to 11 protein entries:     CACO1_HUMAN (see all proteins):
    DKFZp686A11272    TAX1BP1    CALCOCO2

    Find genes that share paralogs with CALCOCO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CALCOCO1 (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114846711,2
    C,F--54104430(+) AACAGA/CAACAG 3 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs796264481,2
    C,F--54104444(+) GAATAT/AAAAAT 3 -- ds50012Minor allele frequency- A:0.02WA NA 238
    rs3750648821,2
    C--54104581(+) TTCTCA/GGCAGT 3 -- ds50010--------
    rs767452181,2
    C,F--54104686(+) ACTGCC/TGCATT 3 -- ds50012Minor allele frequency- T:0.09NA EA 240
    rs1471395111,2
    --54104877(+) TGATAA/CGAACA 3 -- ds50010--------
    rs1881747641,2
    --54104925(+) ATTTGC/TTCAAA 3 -- ut31 nc-transcript-variant0--------
    rs1929242141,2
    --54104960(+) GAAGCC/TTTTAT 3 -- ut31 nc-transcript-variant0--------
    rs1154448231,2
    C,F--54104997(+) GGGGGC/GCTTGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.28WA 118
    rs610981751,2
    C,F--54105038(+) CCCATT/CCCTCA 3 -- nc-transcript-variantut313Minor allele frequency- C:0.26CSA WA 122
    rs37416621,2
    C,F,H--54105074(-) CTCACA/GTGGAA 3 -- nc-transcript-variantut31 ese322Minor allele frequency- G:0.13NS EA NA WA CSA 2260
    rs1823754721,2
    --54105086(+) AGATGC/TGAGGA 3 -- ut31 nc-transcript-variant0--------
    rs1387269151,2
    --54105107(+) AATACA/GGGAAT 3 -- ut31 nc-transcript-variant0--------
    rs1427309021,2
    --54105174(+) AGGGTA/GGGGCA 3 -- ut31 nc-transcript-variant0--------
    rs1866972441,2
    --54105304(+) CCAACA/GGAAAC 3 -- ut31 nc-transcript-variant0--------
    rs1447947741,2
    --54105431(+) GTGGAC/TGATTC 3 -- ut31 nc-transcript-variant0--------
    rs1485524161,2
    C--54105514(+) GCTTCC/TGAACA 3 -- ut31 nc-transcript-variant0--------
    rs1429113911,2
    C--54105515(+) CTTCCA/GAACAG 3 -- ut31 nc-transcript-variant0--------
    rs1923778321,2
    --54105538(+) GGACAA/CAAGAG 3 -- ut31 nc-transcript-variant0--------
    rs1847953961,2
    --54105541(+) CAAAAC/GAGCCA 3 -- ut31 nc-transcript-variant0--------
    rs2010379351,2
    C--54105696(+) CATGAC/GTGTGT 3 -- ut31 nc-transcript-variant0--------
    rs2005334851,2
    C--54105715(+) ATGTAC/TGAGGG 3 -- ut31 nc-transcript-variant0--------
    rs1131227161,2
    C,F--54105727(+) GTAAGA/G/TTCACT 6 -- nc-transcript-variantut313CSA WA NA 4659
    rs2017893721,2
    C--54105868(+) GCCCCC/TAGTGC 5 R G mis10--------
    rs342813791,2
    C,F--54105889(+) CAGGGT/GACCCA 5 /T /P nc-transcript-variantmis13Minor allele frequency- G:0.02NA WA 4418
    rs344898751,2
    C,F--54106046(+) CACAGC/TGTCTT 3 -- int13Minor allele frequency- T:0.09NA 124
    rs783660141,2
    F--54106173(+) ATCTCC/TGTCTG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs37416611,2
    C,H--54106249(-) TGATGC/TTGTCA 3 -- int15Minor allele frequency- T:0.00NS EA 540
    rs37416601,2
    C,H--54106250(-) GTGATG/TCTGTC 3 -- int15Minor allele frequency- T:0.00NS EA 540
    rs1507016511,2
    --54106297(+) AAACCA/GGGACT 3 -- int10--------
    rs1888758601,2
    --54106515(+) GGGGGC/TCATGG 3 -- int10--------
    rs111706551,2
    C,A,H--54106550(+) CCCTAG/AGTACC 3 -- int14Minor allele frequency- A:0.00NS EA 404
    rs1922553481,2
    --54106559(+) CCTACC/TTGGTG 3 -- int10--------
    rs1401752271,2
    --54106609(+) GCAATC/TTGGGC 3 -- int10--------
    rs2012939301,2
    --54106836(+) CTTTCC/TCTCTG 3 -- int10--------
    rs1141951081,2
    C--54106861(+) CCCTCC/GTGGCC 3 -- int10--------
    rs37416561,2
    C,F,H--54107163(-) CCACAG/CTCATT 3 -- int114Minor allele frequency- C:0.11EA NS NA WA 2090
    rs1848717311,2
    --54107167(+) ACTGTC/GGGGGA 3 -- int10--------
    rs1436357591,2
    --54107183(+) AGTGAA/GGCTAT 3 -- int10--------
    rs1467724271,2
    C--54107238(+) GAAGAA/GAGGCT 3 -- int10--------
    rs1893819071,2
    --54107240(+) AGAGAC/GGCTGG 3 -- int10--------
    rs574577051,2
    C,F--54107311(+) TAGCCG/AGGGGT 3 -- int17Minor allele frequency- A:0.15NA WA EA 366
    rs1126768881,2
    C,F--54107365(+) GGATCG/ACTTCA 3 -- int12Minor allele frequency- A:0.03WA 120
    rs1406145621,2
    --54107385(+) GCAGAC/GGCTGC 3 -- int10--------
    rs118321711,2
    C,F,H--54107405(+) AGATCG/ATGCTG 3 -- int12Minor allele frequency- A:0.04NA WA 122
    rs1996924891,2
    --54107503(+) CTGTCC/TTCAGC 5 E syn10--------
    rs1442660901,2
    C,F--54107509(+) TCAGCT/CGGCCC 5 /P syn12Minor allele frequency- C:0.00NA EU 5213
    rs342290621,2
    C,F--54107594(+) AGGAGC/ACTGGG 5 /G /V nc-transcript-variantmis14Minor allele frequency- A:0.01NA EU 5469
    rs1166741281,2
    C,F--54107597(+) AGCCTG/CGGTCT 5 /P /R mis11Minor allele frequency- C:0.00NA 4488
    rs1404318111,2
    C--54107662(+) TCTGAG/CTCTGT 5 /D /E mis11Minor allele frequency- C:0.00NA 3806
    rs2007424271,2
    --54107668(+) TCTGTC/TAGAGC 5 L syn10--------
    rs2001163621,2
    --54107686(+) CAGCCC/TGTAGG 3 -- spa10--------
    rs1164627011,2
    C,F--54107729(+) GTTGTG/AAGGAG 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1488867031,2
    --54107746(+) CAGCTA/GTCTCC 3 -- int10--------
    rs1435474441,2
    C--54107887(+) GGGAAA/GAGGTG 3 -- int10--------
    rs1157046431,2
    C,F--54107929(+) CACAGC/TGGCCT 5 T A mis12Minor allele frequency- T:0.01WA NA 4666
    rs2018720651,2
    C--54107953(+) GGTGGC/TATCCT 5 T A mis10--------
    rs557519361,2
    C--54108140(+) CCTTCA/GGCAAA 3 -- int12Minor allele frequency- G:0.12WA 120
    rs1480729851,2
    --54108148(+) AAAGAC/TTGGGG 3 -- int10--------
    rs22773681,2
    C,F,O,A,H--54108228(-) GACAGG/CGGATG 3 -- int118Minor allele frequency- C:0.46EA NA NS WA CSA 2294
    rs1814529451,2
    --54108259(+) AGAAGC/GCAGGG 3 -- int10--------
    rs1422250501,2
    C--54108267(+) GGGTAC/TGGGCC 3 -- int10--------
    rs2016775671,2
    --54108425(+) GCACAC/TGCAGG 5 H R mis10--------
    rs1457796881,2
    C--54108483(+) CTGAGA/GGAAGA 3 -- int10--------
    rs1386214971,2
    C--54108489(+) GAAGAA/GGGCCC 3 -- int10--------
    rs1858434481,2
    C--54108497(+) CCCAAC/TGGAAT 3 -- int10--------
    rs1486003171,2
    C--54108601(+) CTCTG-/ACACACA 3 -- int10--------
    rs769457711,2
    C,F--54108627(+) CAACAC/TTTCCT 3 -- int16Minor allele frequency- T:0.16WA CSA EA 248
    rs171020461,2
    C,F,H--54108636(+) CTCCAT/CGAGTA 3 -- int122Minor allele frequency- C:0.10NA NS EA WA CSA 2084
    rs1427631981,2
    --54108637(+) TCCATA/GAGTAC 3 -- int10--------
    rs1507523151,2
    --54108647(+) CTTTGC/TCTTGG 3 -- int10--------
    rs1883992411,2
    --54108731(+) GGGGTA/GCAGAG 3 -- int10--------
    rs22773671,2
    C,F,O,H--54108777(-) GGTGAC/TTTAGG 3 -- int129Minor allele frequency- T:0.12EA NA NS WA 4424
    rs1818827061,2
    --54108802(+) ATGTGC/TGCCCT 3 -- int10--------
    rs1379743211,2
    --54108859(+) TGCAAA/GTGAAA 3 -- int10--------
    rs2010137201,2
    --54108959(+) GACAGG/TACCCT 3 -- int10--------
    rs343113411,2
    C,F--54109000(+) CCTTCT/CCCCGG 5 /E /G nc-transcript-variantmis13Minor allele frequency- C:0.00NA WA 4744
    rs2000120091,2
    --54109072(+) GAAGTA/TTCTCT 5 K I mis10--------
    rs1386393291,2
    C,F--54109095(+) AGGATC/ATTGTC 5 /K /N mis12Minor allele frequency- A:0.00NA EU 5875
    rs1865706111,2
    C--54109119(+) GAGATA/GGCCAA 3 -- int10--------
    rs1496250411,2
    C--54109169(+) GCCACC/TGTCAA 3 -- int10--------
    rs1906315901,2
    C--54109280(+) CAGGAC/TATGAC 3 -- int10--------
    rs1832486041,2
    --54109395(+) TACCCC/TGGTTA 3 -- int10--------
    rs1870175771,2
    --54109447(+) AGCCCA/CTCTCC 3 -- int10--------
    rs2022048851,2
    C--54109535(+) GTGGGA/GGCAGT 3 -- int10--------
    rs2014547631,2
    --54109551(+) TCAGAC/TTGCCA 3 -- int10--------
    rs2006793071,2
    C--54109566(+) CCCCCC/TATCCC 3 -- int11Minor allele frequency- T:0.00EU 1323
    rs3687725141,2
    C--54109567(+) CCCCCA/CTCCCT 3 -- int10--------
    rs37416591,2,,4
    C,F,A,H--54109659(-) CGGCAG/AGCTGG 5 /K /R nc-transcript-variantmis131Minor allele frequency- A:0.19EA NA NS WA EU 10667
    rs1416199031,2
    C,F--54109676(+) TCAGCC/GACTTC 5 V syn11Minor allele frequency- G:0.00NA 4552
    rs1394100171,2
    C--54109719(+) GGTCCC/TTGGCT 5 K R mis11Minor allele frequency- T:0.00NA 4552
    rs1997750971,2
    C--54109726(+) GGCTGC/TTGCTG 5 T A mis10--------
    rs37416581,2
    C,F,A,H--54109733(-) GCCAGT/CGCAGC 5 /S nc-transcript-variantsyn1 ese330Minor allele frequency- C:0.38EA NA NS WA CSA EU 9540
    rs2013455611,2
    --54109820(+) AAGGGC/TTCCAG 5 E syn10--------
    rs2008922321,2
    --54109837(+) CTCAGA/GAGAAA 3 -- int10--------
    rs22773701,2
    C,F,O,A,H--54109927(-) ACCCCG/AAGTCC 3 -- int122Minor allele frequency- A:0.27EA NA NS WA 3982
    rs1443348011,2
    --54109928(+) GACTCA/GGGGTT 3 -- int10--------
    rs1910343001,2
    --54109979(+) AGACAC/TGCAGG 3 -- int10--------
    rs171020581,2
    C,F,H--54109980(+) GACACG/ACAGGC 3 -- int128Minor allele frequency- A:0.09NA NS EA WA CSA 2693
    rs1999901221,2
    --54110063(+) CCTGGA/CCTAGG 4 G V int1 nc-transcript-variantmis10--------
    rs1473024471,2
    C,F--54110102(+) TCAGTC/TGCTGA 4 Q R int1 nc-transcript-variantmis12Minor allele frequency- T:0.00NA EU 5875
    rs1401813651,2
    C,F--54110127(+) CTCCTC/GTTGCC 4 Q E int1 nc-transcript-variantmis12Minor allele frequency- G:0.00NA EU 5875
    rs2006436631,2
    C,F--54110128(+) TCCTCT/CTGCCA 4 /Q int1 nc-transcript-variantsyn11Minor allele frequency- C:0.00EU 1323
    rs2015088701,2
    C--54110140(+) CTCTTC/TGCCTC 4 A int1 nc-transcript-variantsyn10--------
    rs22773691,2
    C,F,O,H--54110197(-) CAGGCT/CGAGCT 4 /A nc-transcript-variantsyn1 int130Minor allele frequency- C:0.10EA NA NS EU 10175
    rs1438592381,2
    --54110252(+) TGGCTC/TGGGAG 3 -- int10--------
    rs1159866621,2
    F--54110351(+) TTCTCA/GGCTCA 3 -- int11Minor allele frequency- G:0.03WA 118
    rs1463061361,2
    C--54110488(+) AACTCA/GGTCTT 3 -- int10--------
    rs1395479171,2
    --54110565(+) ATTTCC/TGTCCA 3 -- int10--------
    rs1427825481,2
    --54110590(+) TCCCAC/TGTTAC 3 -- int10--------
    rs1833452281,2
    --54110591(+) CCCACA/GTTACT 3 -- int10--------
    rs764040061,2
    C,F--54110883(+) TCTGTC/TGCCAA 3 -- int11Minor allele frequency- T:0.06WA 118
    rs1114717121,2
    F--54110920(+) GCTCAC/TTGCAG 3 -- int13Minor allele frequency- T:0.12CSA WA 122
    rs1510747431,2
    --54111130(+) ACAGGC/TGTGGG 3 -- int10--------
    rs1409896841,2
    --54111142(+) CACTAA/CACCTG 3 -- int10--------
    rs111706571,2
    C,F,A,H--54111151(+) TGGCCA/GTAAGT 3 -- int122Minor allele frequency- G:0.16NS EA NA WA 2482
    rs1177988961,2
    C,F--54111259(+) TATCTC/AAAACA 3 -- int11Minor allele frequency- A:0.01NA 120
    rs1499320191,2
    C--54111273(+) CACCCA/GCACAT 3 -- int10--------
    rs111706581,2
    C,F,H--54111424(+) ATAAAC/TCCAGG 3 -- int121Minor allele frequency- T:0.15NS EA NA WA 1530
    rs1476042181,2
    --54111492(+) TATTAA/CCAATT 3 -- int10--------
    rs1422908371,2
    --54111583(+) TGGGCA/GGATCA 3 -- int10--------
    rs111706591,2
    C,F--54111625(+) caacaT/Cggtga 3 -- int14Minor allele frequency- C:0.38NA WA 8
    rs47590511,2
    C--54111670(+) TGGGCA/GTGGTG 3 -- int10--------
    rs619227741,2
    --54111758(+) GAGCCA/GAGATC 3 -- int10--------
    rs1165867841,2
    F--54111802(+) AAACTC/TCGTCT 3 -- int11Minor allele frequency- T:0.03WA 118
    rs105794511,2
    C--54111878(+) TTGAC-/ATATGTT 3 -- int10--------
    rs2019838761,2
    --54111881(+) ACATA-/TGTTTCC 3 -- int10--------
    rs1865768731,2
    --54111910(+) TGCAAA/GGCTCA 3 -- int10--------
    rs111706601,2
    C,F,H--54111928(+) TTCTAC/GTGTAT 3 -- int114Minor allele frequency- G:0.13NS EA NA WA 928
    rs1434407581,2
    --54111939(+) TTTCTA/TTTGAA 3 -- int10--------
    rs111706611,2
    C,F,A,H--54111965(+) AGTTGC/TAAGGT 3 -- int122Minor allele frequency- T:0.14NS EA NA WA 2478
    rs1465959061,2
    C--54111985(+) AAAAA-/TTGTTATT 3 -- int10--------
    rs767238851,2
    C--54111987(+) AAATTA/GTTATT 3 -- int10--------
    rs765170481,2
    C,F--54112052(+) AATACG/AGAAAT 3 -- int13Minor allele frequency- A:0.12CSA WA 122
    rs111706621,2
    C,F,H--54112090(+) GTCTTC/TGATAG 3 -- int18Minor allele frequency- T:0.21NS EA WA NA 780
    rs1125439601,2
    F--54112132(+) ATTACC/TTAAGT 3 -- int12Minor allele frequency- T:0.50CSA 4
    rs794110081,2
    F--54112138(+) TAAGTG/CCTTTC 3 -- int13Minor allele frequency- C:0.12CSA WA 121
    rs284518691,2
    C,F--54112362(+) GGCTGA/GAGTTC 3 -- int15Minor allele frequency- G:0.15NA WA CSA 128
    rs111706631,2
    C,F,A--54112381(+) GATCAC/TAGCAC 3 -- int16Minor allele frequency- T:0.30NA WA CSA 130
    rs1480199411,2
    C--54112426(+) TTCCAA/CCTCAG 3 -- int10--------
    rs1898425931,2
    --54112503(+) GAGATA/GGGGTC 3 -- int10--------
    rs1832007531,2
    C--54112849(+) CTGGTC/GTTGAA 3 -- int10--------
    rs1879370331,2
    --54112877(+) GCCTGC/TCTCTG 3 -- int10--------
    rs1932564501,2
    C--54112919(+) CCACTA/GTGCCT 3 -- int10--------
    rs1416560741,2
    --54112999(+) GGAGCG/TCCACA 3 -- int10--------
    rs1136873241,2
    C,F--54113149(+) TACTAC/AAAATA 3 -- int12Minor allele frequency- A:0.33CSA 3
    rs1389302531,2
    --54113158(+) TACAAA/CAGTTA 3 -- int10--------
    rs1850086581,2
    --54113197(+) CCCCGC/TTGCTC 3 -- int10--------
    rs73022581,2
    C,A,H--54113222(+) tgagaG/Attgct 3 -- int14Minor allele frequency- A:0.21NA WA EA 360
    rs754560861,2
    C,F--54113240(+) AGGAGG/TCAGAG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1887484231,2
    --54113271(+) TACCAC/TTGCAC 3 -- int10--------
    rs1926386401,2
    --54113307(+) TCTGTC/GTCCAA 3 -- int10--------
    rs1842990681,2
    --54113380(+) TCCTGA/TTTTAG 3 -- int10--------
    rs1464040531,2
    C--54113415(+) GAGTGC/TACACA 3 -- int10--------
    rs1397546761,2
    C--54113563(+) GTTGCC/TCAAGG 5 E G mis10--------
    rs38328281,2
    C--54113699(-) AGCAG-/CAGCAG 3 -- int10--------
    rs1882545631,2
    --54113863(+) TTTTGC/TTGATG 3 -- int10--------
    rs9411881,2
    C,F,A,H--54113924(-) ACTGCC/TCTTGT 3 -- int124Minor allele frequency- T:0.20NS EA NA WA 2770
    rs9411871,2
    H--54113957(-) ctgGTC/GTAGAT 3 -- int14Minor allele frequency- G:0.00NS EA 420
    rs9411861,2
    C,F,A,H--54114098(-) TCATGC/TTCATT 3 -- int19Minor allele frequency- T:0.21NS EA WA NA 782
    rs9411851,2
    C,F,H--54114129(-) TTCAAA/GTCTGT 3 -- int123Minor allele frequency- G:0.10NS EA NA WA CSA 2372
    rs9411841,2
    C,F,H--54114158(-) ATTTTG/ATGACA 3 -- int111Minor allele frequency- A:0.11NS EA NA WA CSA 670
    rs111706651,2
    H--54114282(+) ctgGTC/TTAGAT 3 -- int14Minor allele frequency- T:0.00NS EA 406
    rs1810752221,2
    --54114467(+) TTTTTA/TAAAAT 3 -- int10--------
    rs1495753911,2
    --54114683(+) TATAGA/GAGAGG 3 -- int10--------
    rs753699111,2
    F--54114805(+) GCTAAG/CAGTTT 3 -- int11Minor allele frequency- C:0.07WA 118
    rs10792691,2
    C,F,H--54114819(+) ATTTGC/TATCTT 3 -- int19Minor allele frequency- T:0.21NS EA NA WA 774
    rs111706661,2
    C,F,H--54114846(+) GATTCC/TATAAC 3 -- int120Minor allele frequency- T:0.11NS EA NA WA 2474
    rs770722961,2
    F--54114874(+) TATAAT/AGTTTC 3 -- int12Minor allele frequency- A:0.12CSA WA 120
    rs20772851,2
    C,F,O,H--54114923(+) GGCCAA/CATCTG 3 -- int130Minor allele frequency- C:0.45NS EA NA WA CSA 2960
    rs1441999121,2
    --54114963(+) TTCCAA/TCCATT 3 -- int10--------
    rs1837901551,2
    --54114964(+) TCCATC/TCATTC 3 -- int10--------
    rs1893151031,2
    --54115150(+) GAAAGC/TGTGTG 3 -- int10--------
    rs9411831,2
    C,F,H--54115179(-) TCTCAA/G/TGCAAG 3 -- int117MN NS EA NA WA 2124
    rs780026151,2
    F--54115185(+) TGAGAG/AAGGGG 3 -- int11Minor allele frequency- A:0.01NA 120
    rs73108481,2
    C,H--54115236(+) GGTCAG/ATGGAC 3 -- int14Minor allele frequency- A:0.00NS EA 414
    rs1487463011,2
    C--54115301(+) TGGATG/ATCATC 5 /D syn11Minor allele frequency- A:0.00NA 4552
    rs2000820261,2
    --54115318(+) CTCCAA/GGATGC 5 L syn10--------
    rs1510238841,2
    C,F--54115357(+) CAGGAT/CGTCCC 5 /I /V mis11Minor allele frequency- C:0.00NA 4552
    rs2021688551,2
    --54115398(+) AAATCC/TCCTGA 5 E G mis10--------
    rs1824414111,2
    --54115557(+) CCTTAA/CCTATC 3 -- int10--------
    rs1423105611,2
    --54115565(+) ATCAAC/TGTGGC 3 -- int10--------
    rs802234691,2
    F--54115618(+) GTCTCA/GTTACA 3 -- int14Minor allele frequency- G:0.15CSA WA 124
    rs10793401,2
    C,F,O,H--54115624(-) CAAACG/TTGTAA 3 -- int119Minor allele frequency- T:0.37NS EA NA MN WA CSA 1749
    rs775921741,2
    C,F--54115625(+) TACACG/ATTTGG 3 -- int11Minor allele frequency- A:0.01NA 120
    rs22934421,2
    C,F,O,H--54115686(-) CAAGGA/CAATAG 3 -- int133Minor allele frequency- C:0.11EA NA NS WA CSA 4511
    rs1476209951,2
    --54115692(+) CCTTGA/GTGCCA 3 -- int10--------
    rs1467313731,2
    C--54115831(+) GCTCCG/ATGTGC 5 /T /M mis11Minor allele frequency- A:0.00NA 4552
    rs2013097841,2
    C--54115843(+) CCTGCA/CTGGCA 5 R M mis10--------
    rs1405339731,2
    C--54115866(+) CTCTCA/GAGCTC 5 L syn10--------
    rs770350731,2
    C,F--54115875(+) TCCTGC/TACTCG 5 V nc-transcript-variantsyn12Minor allele frequency- T:0.00EA NA 4672
    rs353587491,2
    C,F--54115940(+) ATTCCG/ATTCTT 5 /R /W nc-transcript-variantmis13Minor allele frequency- A:0.00NA EU 5951
    rs1443917841,2
    C,F--54115959(+) TCATCG/AAGCTG 5 /L syn11Minor allele frequency- A:0.00NA 4552
    rs47590521,2
    C,F,A,H--54116217(+) CCTCAT/CCCAGC 3 -- int123Minor allele frequency- C:0.21NS EA NA WA CSA 2368
    rs1866192421,2
    --54116290(+) AATTTC/TACCCT 3 -- int10--------
    rs1165854221,2
    C,F--54116385(+) TCACTG/ATGTTG 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1143613811,2
    F--54116418(+) AGCCAT/CAGGTG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1919843621,2
    --54116510(+) AGATGC/TATGCC 3 -- int10--------
    rs1478609821,2
    C--54116524(+) ACACCC/TAGCTA 3 -- int10--------
    rs1812123431,2
    --54116601(+) CCTTAA/GTCTGA 3 -- int10--------
    rs1856274611,2
    --54116645(+) TGAAAC/GCGCAA 3 -- int10--------
    rs1403912271,2
    C--54116646(+) GAAACC/TGCAAC 3 -- int10--------
    rs588978061,2
    C--54116728(+) AAAAA-/AGAAAA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs752482741,2
    --54116746(+) AAAAAG/AAAAAG 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1896956761,2
    --54116984(+) CAGGTC/TTGGGG 3 -- int10--------
    rs1820526261,2
    --54117031(+) AAGCAG/TGTCCT 3 -- int10--------
    rs111706681,2
    H--54117147(+) AAGTTC/ATTATG 3 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1866867091,2
    --54117206(+) ATGTTC/TGTGTA 3 -- int10--------
    rs22934411,2
    C,F,A,H--54117265(-) ACCTCG/CTTGAA 3 -- int124Minor allele frequency- C:0.21EA NS NA WA 3928
    rs1502973431,2
    C,F--54117448(+) CACCAG/ATTCAT 5 /L syn12Minor allele frequency- A:0.00NA EU 5875
    rs1441160781,2
    C,F--54117487(+) AGGGGG/AGCTCT 4 /P /S int1 nc-transcript-variantmis11Minor allele frequency- A:0.00NA 4552
    rs107835961,2
    C,F,A,H--54117592(+) CCCAGG/AACCCC 3 -- int118Minor allele frequency- A:0.19NS EA NA WA 2338
    rs1448701751,2
    C--54117612(+) CTGTCC/GTTGGC 3 -- int10--------
    rs1490629921,2
    C--54117718(+) TTCCTC/TTCTTT 3 -- int10--------
    rs733054281,2
    C,F--54117852(+) CTCCAT/CCGCCC 3 -- int15Minor allele frequency- C:0.18WA CSA EA 126
    rs619227751,2
    C,F--54117878(+) GGCGCG/AATCTT 3 -- int13Minor allele frequency- A:0.05NA 124
    rs1147935721,2
    --54117972(+) ACCACA/GCCTGG 3 -- int10--------
    rs733054301,2
    C,F--54117981(+) GGCCTG/ACAGCT 3 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1918706711,2
    --54118098(+) TAAGTA/GTTAGA 3 -- int10--------
    rs1430635621,2
    --54118144(+) CCACAG/TAATTC 3 -- int10--------
    rs1385788351,2
    --54118157(+) CCTTTC/TCCTCT 3 -- int10--------
    rs1421894001,2
    --54118211(+) TAGATA/GCCCTC 3 -- int10--------
    rs778080761,2
    C,F--54118274(+) CTATCC/TGCTGA 3 -- int11Minor allele frequency- T:0.19NA 120
    rs125817801,2
    H--54118356(+) TGTTTC/TTGAGC 3 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1457953351,2
    --54118372(+) ACCTTA/CTTTCA 3 -- int10--------
    rs3733496791,2
    C--54118405(+) CTCTCA/CCAATT 3 -- int10--------
    rs1473190531,2
    F--54118454(+) TGAATG/TGGGGA 5 P syn1 int11Minor allele frequency- T:0.00NA 4550
    rs360492321,2
    C,F--54118483(+) AGGCAC/TGGAAG 5 M V int1 mis12Minor allele frequency- T:0.01NA 4628
    rs1419776351,2
    C--54118551(+) GGTTGA/GAGAAA 3 -- int10--------
    rs1996131841,2
    --54118562(+) GGTATG/TGTCAT 3 -- int10--------
    rs1166818541,2
    C--54118564(+) TATGGT/CCATGG 3 -- int11Minor allele frequency- C:0.01WA 118
    rs171021811,2
    C,F,H--54118740(+) GGCCTC/GTGTCA 3 -- int123Minor allele frequency- G:0.18NA NS EA WA 2902
    rs1506192121,2
    --54118801(+) AAGAGA/CCCAAT 3 -- int10--------
    rs2018806861,2
    C--54118962(+) AGGTCC/TGGGCT 5 Q R mis10--------
    rs787316041,2
    C,F--54118992(+) CACCAC/TGGGAT 5 H R nc-transcript-variantmis12Minor allele frequency- T:0.00NA EU 5875
    rs1499983531,2
    C,F--54119004(+) GTGCCC/TGGCTT 5 Q R mis12Minor allele frequency- T:0.00NA EU 5875
    rs2015922681,2
    C--54119068(+) GGGTTG/AATAGC 3 -- int11Minor allele frequency- A:0.00EU 1131
    rs1493450101,2
    --54119105(+) CCCCCA/CACAGC 3 -- int10--------
    rs750796491,2
    C,F--54119229(+) ACGTAG/CGTCTG 3 -- int13Minor allele frequency- C:0.09WA NA EA 358
    rs79700101,2
    C,F,A,H--54119247(+) AAGTCC/TGTCCC 3 -- int113Minor allele frequency- T:0.22NA NS EA WA 924
    rs1841644221,2
    --54119297(+) CTTCTG/TAGGGT 3 -- int10--------
    rs1474922371,2
    --54119340(+) ACTGAC/TGGGGA 3 -- int10--------
    rs1158256841,2
    --54119363(+) TACTGC/TGACTT 3 -- int10--------
    rs731040221,2
    C,F--54119414(+) CCTGGC/TTCTTG 3 -- int11Minor allele frequency- T:0.10NA 120
    rs743522431,2
    F--54119458(+) CATTGA/CGAGAG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1148217881,2
    F--54119481(+) ACTCCT/AAAGCT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1155786891,2
    F--54119590(+) GGGGTC/AGAGGG 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1883199061,2
    --54119826(+) GGAACA/GTGGTG 3 -- int10--------
    rs1113463051,2
    C--54119970(+) AGTTC-/AAAAAG 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1931959391,2
    --54120271(+) TCACTC/TCTTTC 3 -- int10--------
    rs1145352471,2
    C,F--54120292(+) ATCTAT/CTTCCT 3 -- int11Minor allele frequency- C:0.01WA 118
    rs1399671321,2
    --54120305(+) GTCACC/TCACAG 3 -- int10--------
    rs774506911,2
    C--54120330(+) AGCCA-/TTTGTC 3 -- int10--------
    rs1841632551,2
    --54120424(+) ACTCAG/TTGGAT 3 -- int10--------
    rs123197411,2
    C,F,H--54120457(+) AAGGAG/ACAACT 3 -- int16Minor allele frequency- A:0.01NS EA WA 532
    rs780816911,2
    C,F--54120458(+) AGGAGC/GAACTT 3 -- int12Minor allele frequency- G:0.11NA EA 240
    rs1444618021,2
    --54120572(+) AGCTTC/TCTAAG 3 -- int10--------
    rs1869976181,2
    --54120995(+) CCACCC/TCCAAT 3 -- int10--------
    rs1170613641,2
    F--54121021(+) ACCAAG/TAACTC 3 -- int11Minor allele frequency- T:0.01EA 120
    rs793264901,2
    F--54121543(+) CGTTGT/CTGGGG 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs784043781,2
    C,F--54121585(+) CATATA/GACGCT 3 -- us2k11Minor allele frequency- G:0.06NA 120
    rs1478117271,2
    --54121727(+) AGTGTC/TAAAGC 3 -- us2k10--------
    rs1484836181,2
    --54121759(+) AGCCTA/TGGCTA 3 -- us2k10--------
    rs1426543061,2
    --54121761(+) CCTTGC/GCTAAT 3 -- us2k10--------
    rs1509364451,2
    --54121889(+) AGAATG/TATGTC 3 -- us2k10--------
    rs1125455561,2
    C,F--54121960(+) TATCCA/GCATCT 3 -- us2k13Minor allele frequency- G:0.13CSA WA 122
    rs171022211,2
    C,F,H--54122073(-) TATGCC/TAAGCT 3 -- us2k127Minor allele frequency- T:0.19NA MN EA NS WA 3244
    rs803064461,2
    F--54122211(+) AAAGAT/CTGACA 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1150430121,2
    F--54122223(+) GTCTCC/TCACAC 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs38091581,2
    C,F--54122329(-) TTTAAT/CGCAGA 3 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1407427841,2
    C--54122404(+) AGTTAC/TGGAGC 3 -- us2k10--------
    rs1918241751,2
    --54122471(+) CTGCCC/TTCAGT 3 -- us2k10--------
    rs1156298991,2
    F--54122601(+) AGGAGG/ATAGCT 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1836730591,2
    --54122615(+) GGTCTA/GGAGTG 3 -- us2k10--------
    rs1170306711,2
    F--54122873(+) TTGCCT/AGGAGT 3 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1142628081,2
    F--54122910(+) AGATTT/GAAGCA 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs795070581,2
    C,F--54122948(+) AAACTC/TTGGCA 3 -- us2k11Minor allele frequency- T:0.19NA 120
    rs1431568141,2
    --54123055(+) AGTAAC/TGTGAA 3 -- us2k10--------
    rs1895328601,2
    --54123160(+) TAATAA/TATGTA 3 -- us2k10--------
    rs45268071,2
    F--54123187(-) tacatT/Atatta 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1819972941,2
    --54123296(+) AAGCTG/TCTTCT 3 -- us2k10--------
    rs1452010131,2
    ----54119005(+) TGCCCG/AGCTTA 5 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs3747461361,2
    ----54121796(+) ACACCA/GAGCTA 3 -- us2k10--------
    rs3689262551,2
    ----54118963(+) GGTCCA/GGGCTA 5 R W mis10--------
    rs2004083241,2
    ----54108458(+) CCCGCT/GTACTT 5 /K /T mis11Minor allele frequency- G:0.00EU 1321
    rs3716075501,2
    ----54117471(+) GCTCTC/TGGAAC 4 Q R int1 nc-transcript-variantmis10--------
    rs3717385851,2
    ----54118548(+) CAAGGA/TTGGAG 3 -- int10--------
    rs3703006871,2
    ----54113507(+) AATCAA/CCTCTG 3 -- int10--------
    rs3712486481,2
    ----54108246(+) ATCAGA/CAATAA 3 -- int10--------
    rs3763140771,2
    ----54110290(+) GGTTCC/TCTTCT 3 -- int10--------
    rs3753472121,2
    ----54105733(+) TCACTC/GAAAGG 5 Q E mis10--------
    rs3691028961,2
    ----54107678(+) CTGCCA/GGGCAG 5 P L mis10--------
    rs569160641,2
    ----54111989(+) AAATT-/GTTATTTG 5 -- int1 cds10--------
    rs3751983921,2
    ----54106984(+) ATCTTC/TAGCCT 5 K E mis10--------
    rs3746068781,2
    ----54116360(+) ATGTG-/TTTTTT 3 -- int10--------
    rs3771563711,2
    ----54107664(+) TGAGTC/TTGTCA 5 N D mis10--------
    rs3691319121,2
    ----54115020(+) ACAAT-/TAAGTG 3 -- int10--------
    rs3676683771,2
    ----54118381(+) CAAACC/GTCCAC 3 -- int10--------
    rs3682487751,2
    ----54108490(+)