Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CALCOCO1 Gene

Aliases for CALCOCO1 Gene

  • Calcium Binding And Coiled-Coil Domain 1 2 3
  • Coiled-Coil Leucine Zipper Coactivator 1 2 3
  • Inorganic Pyrophosphatase Activator 2 3
  • Coiled-Coil Coactivator Protein 3 4
  • Sarcoma Antigen NY-SAR-3 3 4
  • Calphoglin 3 4
  • Calcium-Binding And Coiled-Coil Domain-Containing Protein 1 3
  • KIAA1536 4
  • PP13275 3
  • Cocoa 3

External Ids for CALCOCO1 Gene

Previous GeneCards Identifiers for CALCOCO1 Gene

  • GC12M052392
  • GC12M054105
  • GC12M051142

Summaries for CALCOCO1 Gene

GeneCards Summary for CALCOCO1 Gene

CALCOCO1 (Calcium Binding And Coiled-Coil Domain 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAX1BP1.

UniProtKB/Swiss-Prot for CALCOCO1 Gene

  • Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity).

  • Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.

Gene Wiki entry for CALCOCO1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCOCO1 Gene

Genomics for CALCOCO1 Gene

Regulatory Elements for CALCOCO1 Gene

Genomic Location for CALCOCO1 Gene

Start:
53,708,517 bp from pter
End:
53,727,745 bp from pter
Size:
19,229 bases
Orientation:
Minus strand

Genomic View for CALCOCO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCOCO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCOCO1 Gene

Proteins for CALCOCO1 Gene

  • Protein details for CALCOCO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z2-CACO1_HUMAN
    Recommended name:
    Calcium-binding and coiled-coil domain-containing protein 1
    Protein Accession:
    Q9P1Z2
    Secondary Accessions:
    • B3KVA8
    • Q6FI59
    • Q71RC3
    • Q86WF8
    • Q96JU3
    • Q9H090

    Protein attributes for CALCOCO1 Gene

    Size:
    691 amino acids
    Molecular mass:
    77336 Da
    Quaternary structure:
    • Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By similarity).
    SequenceCaution:
    • Sequence=BAA96060.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CALCOCO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCOCO1 Gene

Proteomics data for CALCOCO1 Gene at MOPED

Post-translational modifications for CALCOCO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALCOCO1 Gene

Domains for CALCOCO1 Gene

Protein Domains for CALCOCO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Z2

UniProtKB/Swiss-Prot:

CACO1_HUMAN :
  • Q9P1Z2
Domain:
  • The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
  • The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).
  • Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.
Family:
  • Belongs to the CALCOCO family.
genes like me logo Genes that share domains with CALCOCO1: view

No data available for Gene Families for CALCOCO1 Gene

Function for CALCOCO1 Gene

Molecular function for CALCOCO1 Gene

UniProtKB/Swiss-Prot Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity).
UniProtKB/Swiss-Prot Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.

Gene Ontology (GO) - Molecular Function for CALCOCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003712 transcription cofactor activity IDA 16344550
GO:0003713 transcription coactivator activity ISS --
GO:0005515 protein binding IPI 16189514
GO:0008013 beta-catenin binding IPI 16344550
genes like me logo Genes that share ontologies with CALCOCO1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CALCOCO1 Gene

Localization for CALCOCO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCOCO1 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCOCO1 Gene COMPARTMENTS Subcellular localization image for CALCOCO1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CALCOCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CALCOCO1: view

Pathways for CALCOCO1 Gene

SuperPathways for CALCOCO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CALCOCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated ISS --
GO:0007165 signal transduction ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030518 intracellular steroid hormone receptor signaling pathway ISS --
GO:0045893 positive regulation of transcription, DNA-templated IMP 16344550
genes like me logo Genes that share ontologies with CALCOCO1: view

No data available for Pathways by source for CALCOCO1 Gene

Compounds for CALCOCO1 Gene

(1) HMDB Compounds for CALCOCO1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CALCOCO1: view

Transcripts for CALCOCO1 Gene

Unigene Clusters for CALCOCO1 Gene

Calcium binding and coiled-coil domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - - -
SP16: - - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - -
SP22:

ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
SP1: -
SP2: -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CALCOCO1 Gene

GeneLoc Exon Structure for
CALCOCO1
ECgene alternative splicing isoforms for
CALCOCO1

Expression for CALCOCO1 Gene

mRNA expression in normal human tissues for CALCOCO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALCOCO1 Gene

SOURCE GeneReport for Unigene cluster for CALCOCO1 Gene Hs.156667

genes like me logo Genes that share expressions with CALCOCO1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALCOCO1 Gene

Orthologs for CALCOCO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCOCO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCOCO1 35
  • 99.71 (n)
  • 99.71 (a)
CALCOCO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALCOCO1 35
  • 91.11 (n)
  • 92.92 (a)
CALCOCO1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCOCO1 35
  • 88.84 (n)
  • 91.88 (a)
CALCOCO1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcoco1 35
  • 87.94 (n)
  • 89.29 (a)
Calcoco1 16
Calcoco1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALCOCO1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912282 35
  • 87.8 (n)
  • 89.15 (a)
lizard
(Anolis carolinensis)
Reptilia CALCOCO1 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398195 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493024 35
  • 56.63 (n)
  • 49.33 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
calcoco1a 35
  • 51.05 (n)
  • 39.32 (a)
calcoco1a 36
  • 33 (a)
OneToMany
calcoco1b 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.823 36
  • 21 (a)
OneToMany
Species with no ortholog for CALCOCO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCOCO1 Gene

ENSEMBL:
Gene Tree for CALCOCO1 (if available)
TreeFam:
Gene Tree for CALCOCO1 (if available)

Paralogs for CALCOCO1 Gene

Paralogs for CALCOCO1 Gene

genes like me logo Genes that share paralogs with CALCOCO1: view

Variants for CALCOCO1 Gene

Sequence variations from dbSNP and Humsavar for CALCOCO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941183 -- 53,721,395(-) TCTCA(A/G/T)GCAAG intron-variant
rs941184 -- 53,720,374(-) ATTTT(A/G)TGACA intron-variant
rs941185 -- 53,720,345(-) TTCAA(A/G)TCTGT intron-variant
rs941186 -- 53,720,314(-) TCATG(C/T)TCATT intron-variant
rs941187 -- 53,720,173(-) ctgGT(C/G)TAGAT intron-variant

Relevant External Links for CALCOCO1 Gene

HapMap Linkage Disequilibrium report
CALCOCO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CALCOCO1 Gene

Disorders for CALCOCO1 Gene

Relevant External Links for CALCOCO1

Genetic Association Database (GAD)
CALCOCO1
Human Genome Epidemiology (HuGE) Navigator
CALCOCO1
genes like me logo Genes that share disorders with CALCOCO1: view

No data available for UniProtKB/Swiss-Prot for CALCOCO1 Gene

Publications for CALCOCO1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PMID: 15522220) Takahashi K. … Ingi T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for CALCOCO1 Gene

  • antibodies-online proteins for CALCOCO1
  • antibodies-online antibodies for CALCOCO1
  • antibodies-online kits for CALCOCO1

Sources for CALCOCO1 Gene

Back to Top

Content