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CALCOCO1 Gene

protein-coding   GIFtS: 53
GCID: GC12M054105

Calcium Binding And Coiled-Coil Domain 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding And Coiled-Coil Domain 11 2     Cocoa2
Coiled-Coil Leucine Zipper Coactivator 11 2     Calcium-Binding And Coiled-Coil Domain-Containing Protein 12
Inorganic Pyrophosphatase Activator1 2     calphoglin2
Coiled-Coil Coactivator Protein2 3     Calphoglin3
Sarcoma Antigen NY-SAR-32 3     KIAA15363

External Ids:    HGNC: 293061   Entrez Gene: 576582   Ensembl: ENSG000000128227   UniProtKB: Q9P1Z23   

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALCOCO1 Gene:
CALCOCO1 (calcium binding and coiled-coil domain 1) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
utilization of two different activation regions (By similarity)
Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
growth

Gene Wiki entry for CALCOCO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   Gfi-1   HNF-4alpha1   Pax-3   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCOCO1 promoter sequence
   Search Chromatin IP Primers for CALCOCO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCOCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054105:  view genomic region     (about GC identifiers)

Start:
54,104,902 bp from pter      End:
54,121,529 bp from pter
Size:
16,628 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CALCOCO1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)
Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1  
Size: 691 amino acids; 77336 Da
Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of
GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By
similarity)
Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;
Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090
Alternative splicing: 4 isoforms:  Q9P1Z2-1   Q9P1Z2-2   Q9P1Z2-3   Q9P1Z2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Explore proteomics data for CALCOCO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALCOCO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137154.1  NP_065949.1  

    ENSEMBL proteins: 
     ENSP00000456437   ENSP00000397189   ENSP00000262059   ENSP00000447647   ENSP00000449960  
     ENSP00000450083   ENSP00000448621   ENSP00000447117   ENSP00000449058   ENSP00000446820  
     ENSP00000448026   ENSP00000450012   ENSP00000449796  

    CALCOCO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALCOCO1
    OriGene Protein Over-expression Lysate for CALCOCO1
    OriGene MassSpec for CALCOCO1
    OriGene Custom Protein Services for CALCOCO1
    GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
    Novus Biologicals CALCOCO1 Protein
    Novus Biologicals CALCOCO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALCOCO1

     
    Search eBioscience for Proteins for CALCOCO1 

    CALCOCO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CALCOCO1
    Novus Biologicals CALCOCO1 Antibodies
    Abcam antibodies for CALCOCO1
    Cloud-Clone Corp. Antibodies for CALCOCO1
    ThermoFisher Antibodies for CALCOCO1
    LSBio Antibodies in human, mouse, rat for CALCOCO1

    CALCOCO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALCOCO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALCOCO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALCOCO1
    Cloud-Clone Corp. CLIAs for CALCOCO1
    Search eBioscience for ELISAs for CALCOCO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q9P1Z2

    ProtoNet protein and cluster: Q9P1Z2

    1 Blocks protein domain: IPB012852 Coiled-coil transcriptional coactivator-like

    UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for
    coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)
    Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of
    LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic
    cooperation (By similarity)
    Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160
    coactivators (By similarity)
    Similarity: Belongs to the CALCOCO family


    Find genes that share domains with CALCOCO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACO1_HUMAN, Q9P1Z2
    Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
    through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
    or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
    proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
    Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
    interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
    utilization of two different activation regions (By similarity)
    Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
    component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
    metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
    growth

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003712transcription cofactor activity IDA16344550
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI16344550
    GO:0008013beta-catenin binding IPI16344550
         
    Find genes that share ontologies with CALCOCO1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Calcoco1 (no phenotypes)

    Find genes that share phenotypes with CALCOCO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Calcoco1tm1Lex for CALCOCO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALCOCO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALCOCO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCOCO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCOCO1

    miRNA
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    Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALCOCO1
    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALCOCO1

    Clone
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    OriGene clones in human, mouse for CALCOCO1 (see all 11)
    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    Sino Biological Human cDNA Clone for CALCOCO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CALCOCO1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CACO1_HUMAN, Q9P1Z2: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CALCOCO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALCOCO1
    Interactions:

        GeneGlobe Interaction Network for CALCOCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CALCOCO1 (Q9P1Z22, 3 ENSP000002620594) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ISS--
    GO:0007165signal transduction ISS--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-templated IMP16344550

    Find genes that share ontologies with CALCOCO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALCOCO1 (CACO1)

    1 HMDB Compound for CALCOCO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts): 
    NM_001143682.1  NM_020898.2  

    Unigene Cluster for CALCOCO1:

    Calcium binding and coiled-coil domain 1
    Hs.156667  [show with all ESTs]
    Unigene Representative Sequence: AF370415
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)
    ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)
    ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619
    ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177
    ENST00000552623 ENST00000549349
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1
    Clone
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    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1
    Primer
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    OriGene qPCR primer pairs and template standards for CALCOCO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCOCO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCOCO1
      QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
      QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

    Additional mRNA sequence: 

    AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1 
    AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1 
    CR533567.1 NR_026554.1 

    24 DOTS entries:

    DT.95304157  DT.417860  DT.95237851  DT.40296235  DT.91758204  DT.121124009  DT.100828568  DT.100828563 
    DT.100828566  DT.91710713  DT.95237849  DT.121123986  DT.121124011  DT.121124014  DT.91758207  DT.91758212 
    DT.91758213  DT.95228852  DT.100828572  DT.121123989  DT.91758216  DT.99969194  DT.100828561  DT.121123975 

    397 AceView cDNA sequences (see top 24):

    CA445783 BM467220 AI693806 BQ004571 CA439740 CB141179 AI625296 AI143576 
    BQ072576 AW513707 BM711961 BG423110 BU557143 BQ026889 AI347694 CD365444 
    BQ007149 BP335596 AW468451 BP357445 AI216118 AA486443 T17140 BQ954329 
    CA413354 AB040969 AY211909 AI823604 BU615837 CR598215 AI623430 AI690601 
    CD630458 AW069584 AI814511 AA699848 AK027881 NM_020898 AA333191 AY358397 
    AA338668 AW204733 T29986 AW614496 BQ899098 BM694497 CR597517 BE736205 
    CA437503 AA913672 BQ220635 BM914308 AI758628 BX479939 AL546118 AU280757 
    CF125303 AI270433 BU175677 W52224 AA449488 BM975956 AI635256 CD723746 
    BC003177 AA338669 AI222561 AA322811 BQ774442 AL539536 AI796841 AW273283 
    AI278925 BE336737 AW769680 CA443598 BI711426 CA394013 AI284738 AL136895 
    BX441267 BU509166 CD517431 BE220385 CD673306 W32445 BU731112 CO246143 
    BG708909 BQ006482 BF970513 AI279605 BM804376 AA404357 BE674073 AA588340 
    BM545300 BI856204 AL553166 CD630457 AI598090 AA340064 AI383820 AL041533 
    AW268866 BM751046 BE336817 AI949970 BQ019869 AK092788 AI435230 CD556532 
    BM738840 CF132510 AI669311 BI868858 BX417050 BI824665 CA439304 CB994493 
    AI684239 CB266515 AI057122 R71399 CD630459 BX414205 BF345328 BX491979 
    BF757309 BM917139 BQ878854 BM805636 BP362824 AV692500 AK122773 AI673042 
    BG740281 BQ232541 AI002424 BP335668 BE393640 BG335865 AL534831 BG110227 
    CO400209 BQ226622 BQ067598 BP358502 BG911367 BG982545 BG393503 BP356583 
    BQ067321 CD366757 AA678669 CA444304 AA918815 BG480069 AI394073 CR533567 
    AI656817 BX417577 Z19145 CF619431 AI956118 AI689275 BG546008 AI636377 
    CD365850 BU177030 AW204364 BE646649 BG027867 BE675160 CO245451 BQ717762 
    BE873522 BX538208 BG913313 BX479940 BX462598 BX417990 CK003719 CB854420 
    AA412555 BE221437 W74596 AA115705 BM906296 BE832258 BI546817 BG481452 
    AI032429 AI820025 AI052030 BG702586 AA403094 AX747731 BM543834 BE502977 
    BF001330 CO248660 AW206064 BG253637 AA857400 BX442601 AF370415 AA449655 
    BX496454 AW905049 BG768447 AL534832 AA448358 BG913116 R70184 BM970508 
    AI559819 AI433186 BX646117 CB963824 BQ582145 BI836442 BI057248 BX408704 
    CB851214 BX491987 W44384 AA057304 AI926053 BE158919 AI436598 AI927979 
    AA322890 R98648 C15956 H26270 AV656372 AJ707440 BU621444 AI016093 
    AL577459 BF678910 BE206122 R68661 H25688 CO249343 AW863792 T66797 
    BG387218 R98647 AA227933 W19248 BX490967 AA115704 BG002406 AW001295 
    BG055775 BG998411 CD630464 AW749238 AI051044 AI446160 CO245181 BP359420 
    BF960790 BI667381 R53615 AA227618 BF913239 BE244225 BX471985 BF092639 
    AA326259 CO245491 BQ305186 AI832804 CD630460 BX344270 N89933 BE311616 
    AI832884 W45019 R51945 BE168507 BF948714 AL702258 BF761922 BQ214957 
    BQ367098 BM013364 BI047456 BE770840 BI462569 BX407600 AW206965 BI047821 
    AA536083 H51450 BF433503 BX344269 BG823417 AL706439 BE266811 AA705325 
    BE770825 BF316346 AA318176 AL525340 BE247207 BI044570 CK724876 CD630463 
    BE206206 AA694598 AI674438 BM988327 AL525380 T66796 BF093608 AA326758 
    BG998683 AI493866 CD630455 BF887569 BX407601 AW840176 BG480631 AL554743 
    BF941302 CD630456 BQ186794 BM914291 AW749419 BG943548 BF833833 AV723315 
    BF325711 T90545 AW899522 BG950017 AA677958 AA730987 AA037652 BQ881997 
    H25103 AL576342 W44323 AW189961 AW578511 BG978360 R68713 BI019864 
    CO248355 BM016847 BQ346183 AA197253 AW138656 T71651 BG978713 R47284 
    CO245103 BE837548 AW952121 CD630462 D60506 AI902380 AA197254 AA058747 
    D60735 BE903331 BE697903 R53402 BE812281 AW956267 M62229 W56105 
    D60736 BG954059 BG949999 BI767770 BG013616 AA326742 BQ322393 AW749236 
    CD630461 CD630453 T82074 BF516005 R22488 BQ355614 BE066411 BE183281 
    CD630454 BE541326 BF355798 AW753833 BX435595 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                      -     -     -                             -                             -                       -                 -   
    SP2:                                                                                -                             -                       -                 -   
    SP3:                                      -     -     -                             -     -     -     -     -     -                       -                 -   
    SP4:                                      -     -     -                             -     -     -                 -                       -                 -   
    SP5:                                                                                -                             -                       -                 -   

    ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                      -         
    SP2:                                                                                      -         
    SP3:                                                                                      -         
    SP4:  -     -     -                                                                       -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CALCOCO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALCOCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGAAATA
    CALCOCO1 Expression
    About this image


    CALCOCO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CALCOCO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALCOCO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156667
        Custom PCR Arrays for CALCOCO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALCOCO1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CALCOCO1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcoco11 , 5 calcium binding and coiled coil domain 11, 5 87.94(n)1
    89.29(a)1
      15 (57.81 cM)5
    674881  NM_026192.31  NP_080468.11 
     1027067795 
    lizard
    (Anolis carolinensis)
    Reptilia CALCOCO16
    calcium binding and coiled-coil domain 1
    53(a)
    1 ↔ 1
    2(72772605-72806632)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981952 nuclear domain-10 protein NDP52 72.1(n)    AF312719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC051625.12   -- 75.69(n)   386968  BC051625.1 


    ENSEMBL Gene Tree for CALCOCO1 (if available)
    TreeFam Gene Tree for CALCOCO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALCOCO1 gene
    CALCOCO22  TAX1BP12  
    3 SIMAP similar genes for CALCOCO1 using alignment to 11 protein entries:     CACO1_HUMAN (see all proteins):
    DKFZp686A11272    TAX1BP1    CALCOCO2

    Find genes that share paralogs with CALCOCO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALCOCO1 (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114846711,2
    C,F--54104430(+) AACAGA/CAACAG 3 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs796264481,2
    C,F--54104444(+) GAATAT/AAAAAT 3 -- ds50012Minor allele frequency- A:0.02WA NA 238
    rs3750648821,2
    C--54104581(+) TTCTCA/GGCAGT 3 -- ds50010--------
    rs767452181,2
    C,F--54104686(+) ACTGCC/TGCATT 3 -- ds50012Minor allele frequency- T:0.09NA EA 240
    rs1471395111,2
    --54104877(+) TGATAA/CGAACA 3 -- ds50010--------
    rs1881747641,2
    --54104925(+) ATTTGC/TTCAAA 3 -- ut31 nc-transcript-variant0--------
    rs1929242141,2
    --54104960(+) GAAGCC/TTTTAT 3 -- ut31 nc-transcript-variant0--------
    rs1154448231,2
    C,F--54104997(+) GGGGGC/GCTTGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.28WA 118
    rs610981751,2
    C,F--54105038(+) CCCATT/CCCTCA 3 -- nc-transcript-variantut313Minor allele frequency- C:0.26CSA WA 122
    rs37416621,2
    C,F,H--54105074(-) CTCACA/GTGGAA 3 -- nc-transcript-variantut31 ese322Minor allele frequency- G:0.13NS EA NA WA CSA 2260

    HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALCOCO1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCOCO1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCOCO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CALCOCO1           About GenesLikeMe

    Genetic Association Database (GAD): CALCOCO1
    Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

    Export disorders for CALCOCO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALCOCO1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CALCOCO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4 Haiman C.A....Press M.F. (BMC Cancer 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)1, 9 Takahashi K....Ingi T. (Biochem. Biophys. Res. Commun. 2004)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57658 HGNC: 29306 AceView: KIAA1536 Ensembl:ENSG00000012822 euGenes: HUgn57658
    ECgene: CALCOCO1 H-InvDB: CALCOCO1

    (According to HUGE)
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    HUGE: KIAA1536

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CALCOCO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CALCOCO1 gene:
    Search GeneIP for patents involving CALCOCO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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