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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALCOCO1 Gene

protein-coding   GIFtS: 54
GCID: GC12M054105

Calcium Binding And Coiled-Coil Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Calcium Binding And Coiled-Coil Domain 11 2     Cocoa2
Coiled-Coil Leucine Zipper Coactivator 11 2     Calcium-Binding And Coiled-Coil Domain-Containing Protein 12
Inorganic Pyrophosphatase Activator1 2     calphoglin2
Coiled-Coil Coactivator Protein2 3     Calphoglin3
Sarcoma Antigen NY-SAR-32 3     KIAA15363

External Ids:    HGNC: 293061   Entrez Gene: 576582   Ensembl: ENSG000000128227   UniProtKB: Q9P1Z23   
ORGUL members:         
NONCODE14:n373230 n373479 n379749 n379987 n379849 see all 14      

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CALCOCO1 Gene: 
CALCOCO1 (calcium binding and coiled-coil domain 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CALCOCO1 include sarcoma, and panic disorder. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
utilization of two different activation regions (By similarity)
Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
growth

Gene Wiki entry for CALCOCO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   Gfi-1   HNF-4alpha1   Pax-3   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCOCO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALCOCO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCOCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054105:  view genomic region     (about GC identifiers)

Start:
54,104,902 bp from pter      End:
54,121,529 bp from pter
Size:
16,628 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CALCOCO1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)
Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1  
Size: 691 amino acids; 77336 Da
Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of
GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By
similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)
Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;
Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090
Alternative splicing: 4 isoforms:  Q9P1Z2-1   Q9P1Z2-2   Q9P1Z2-3   Q9P1Z2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Explore proteomics data for CALCOCO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P1Z2

  • CALCOCO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALCOCO1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137154.1  NP_065949.1  

    ENSEMBL proteins: 
     ENSP00000456437   ENSP00000397189   ENSP00000262059   ENSP00000447647   ENSP00000449960  
     ENSP00000450083   ENSP00000448621   ENSP00000447117   ENSP00000449058   ENSP00000446820  
     ENSP00000448026   ENSP00000450012   ENSP00000449796  

    Human Recombinant Protein Products for CALCOCO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALCOCO1
    OriGene Protein Over-expression Lysate for CALCOCO1
    OriGene MassSpec for CALCOCO1 
    OriGene Custom Protein Services for CALCOCO1
    GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
    Novus Biologicals CALCOCO1 Protein
    Novus Biologicals CALCOCO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALCOCO1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    CALCOCO1 for ontologies           About GeneDecksing



    CALCOCO1 Antibody Products: 
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    GenScript Custom Superior Antibodies Services for CALCOCO1
    Novus Biologicals CALCOCO1 Antibodies
    Abcam antibodies for CALCOCO1
    Cloud-Clone Corp. Antibodies for CALCOCO1 
    ThermoFisher Antibodies for CALCOCO1
    LSBio Antibodies in human, mouse, rat for CALCOCO1 

    Assay Products for CALCOCO1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CALCOCO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALCOCO1 
    Cloud-Clone Corp. CLIAs for CALCOCO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q9P1Z2

    ProtoNet protein and cluster: Q9P1Z2

    1 Blocks protein domain: IPB012852 Coiled-coil transcriptional coactivator-like

    UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for
    coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)
    Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of
    LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic
    cooperation (By similarity)
    Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160
    coactivators (By similarity)
    Similarity: Belongs to the CALCOCO family


    CALCOCO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACO1_HUMAN, Q9P1Z2
    Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
    through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
    or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
    proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
    Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
    interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
    utilization of two different activation regions (By similarity)
    Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
    component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
    metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
    growth

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003712transcription cofactor activity IDA16344550
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI16344550
    GO:0008013beta-catenin binding IPI16344550
         
    CALCOCO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Calcoco1 (no phenotypes)

    CALCOCO1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calcoco1tm1Lex for CALCOCO1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALCOCO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALCOCO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCOCO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCOCO1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALCOCO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALCOCO1
    Sirion Biotech Customized adenovirus for overexpression of CALCOCO1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALCOCO1 (see all 11)
    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1
    Sirion Biotech Customized lentivirus for stable overexpression of CALCOCO1 
                         Customized lentivirus expression plasmids for stable overexpression of CALCOCO1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CALCOCO1
    Search LifeMap BioReagents cell lines for CALCOCO1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALCOCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/44 Interacting proteins for CALCOCO1 (Q9P1Z22, 3 ENSP000002620594) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ISS--
    GO:0007165signal transduction ISS--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-dependent IMP16344550

    CALCOCO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALCOCO1 (CACO1)

    1 HMDB Compound for CALCOCO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CALCOCO1 / CACO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts): 
    NM_001143682.1  NM_020898.2  

    Unigene Cluster for CALCOCO1:

    Calcium binding and coiled-coil domain 1
    Hs.156667  [show with all ESTs]
    Unigene Representative Sequence: AF370415
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)
    ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)
    ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619
    ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177
    ENST00000552623 ENST00000549349
    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1
    Clone
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    OriGene ORF clones in mouse, rat for CALCOCO1
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    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1
    Sirion Biotech Customized lentivirus for stable overexpression of CALCOCO1 
                         Customized lentivirus expression plasmids for stable overexpression of CALCOCO1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

    Additional mRNA sequence: 

    AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1 
    AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1 
    CR533567.1 NR_026554.1 

    24 DOTS entries:

    DT.95304157  DT.417860  DT.95237851  DT.40296235  DT.91758204  DT.121124009  DT.100828568  DT.100828563 
    DT.100828566  DT.91710713  DT.95237849  DT.121123986  DT.121124011  DT.121124014  DT.91758207  DT.91758212 
    DT.91758213  DT.95228852  DT.100828572  DT.121123989  DT.91758216  DT.99969194  DT.100828561  DT.121123975 

    397 AceView cDNA sequences (see top 24):

    CA443598 CR598215 AI758628 AA449488 AI823604 T17140 CF125303 BP357445 
    CA394013 BQ899098 AL539536 CD365444 CB141179 BP335596 AL136895 AW204733 
    CA439740 AI693806 AA338669 CA413354 CD723746 AI623430 BU557143 BM694497 
    AW513707 CD517431 AB040969 BQ072576 AI625296 AI143576 AA333191 AL546118 
    BQ007149 BQ954329 BM914308 BE336737 AI347694 CR597517 BQ026889 AI222561 
    BG423110 AY211909 AU280757 BM711961 BX479939 BU615837 BQ004571 NM_020898 
    CA445783 AA322811 AY358397 AI796841 BQ220635 AA913672 BI711426 AA486443 
    AW069584 AW614496 T29986 AI278925 BX441267 BE220385 BQ774442 W52224 
    AW769680 AW468451 CD630458 AI270433 BM975956 BU175677 BU509166 AW273283 
    AI216118 AA699848 BM467220 AI635256 AI690601 AA338668 BC003177 AK027881 
    AI284738 BE736205 AI814511 CA437503 BG480069 BM970508 BE832258 BX462598 
    CB266515 CD556532 BP358502 CK003719 AF370415 BM804376 BG708909 AL553166 
    BX479940 R71399 BX646117 BU731112 AI002424 AA918815 BG768447 BG110227 
    BF757309 AI956118 BM805636 AI559819 BP335668 BE873522 AI057122 W74596 
    BG740281 CD365850 AX747731 BQ226622 BM751046 BX538208 AI383820 BI868858 
    BE674073 BX417050 BM917139 BF345328 BG913313 AA448358 BG335865 CA439304 
    CB994493 BG702586 AA115705 BX496454 CO248660 AA588340 AK092788 BM738840 
    AI433186 BQ019869 CF619431 CO400209 BG253637 AA449655 BX414205 BU177030 
    BE393640 BG913116 AI394073 AK122773 BG027867 AI052030 BQ717762 BX491979 
    BI546817 CF132510 AI032429 BG911367 AI949970 CD630459 W32445 AW905049 
    CO245451 BF001330 AL534832 CB854420 BM906296 AI435230 AI279605 AA857400 
    AI820025 BI824665 AI684239 AL041533 AL534831 BG393503 BQ067321 AA412555 
    BE221437 BE675160 BX417577 BQ006482 BG546008 BF970513 CD673306 CB963824 
    BG481452 AA340064 AI669311 CO246143 BX442601 AW268866 AA404357 BP356583 
    AA403094 BX417990 AV692500 BI856204 AI598090 R70184 BE646649 AW206064 
    BE336817 BM545300 AW204364 AI636377 BQ878854 BE502977 BQ232541 AI656817 
    BM543834 BQ067598 AA678669 AI689275 CD630457 CD366757 AI673042 BG982545 
    CR533567 CA444304 BP362824 Z19145 BI667381 CD630464 BQ305186 AA326259 
    BP359420 BU621444 CD630460 C15956 BI836442 AI926053 AI927979 BG387218 
    BE244225 BX408704 AI436598 AI016093 BF960790 R53615 AV656372 AI446160 
    BF678910 BX471985 BF092639 BE158919 AA322890 AA227933 BI057248 AA057304 
    T66797 AI051044 BX491987 BE206122 BG055775 R98648 BQ582145 CO245491 
    AA227618 BF913239 H25688 AW749238 AI832884 R68661 AL577459 W19248 
    CO249343 CO245181 AJ707440 R98647 AI832804 W44384 N89933 W45019 
    AA115704 BX344270 CB851214 AW863792 BG998411 H26270 AW001295 BX490967 
    BG002406 BE311616 AL525380 BI044570 BF761922 BE770825 BI047456 AL706439 
    BX407600 AW206965 BE770840 BF948714 AI493866 BQ214957 BI462569 CD630463 
    BI047821 AA694598 BE168507 H51450 AI674438 R51945 BE247207 BM988327 
    AL525340 BF093608 BM013364 BF433503 BE266811 CK724876 BF316346 AA318176 
    BQ367098 BG823417 CD630455 BX344269 BE206206 AA705325 BG998683 T66796 
    AA326758 AA536083 AL702258 AW749419 T90545 BG480631 AA677958 BX407601 
    AW840176 H25103 BF941302 CD630456 BM914291 AL576342 BF325711 BG943548 
    BF887569 AA037652 W44323 AW189961 AV723315 BF833833 AA730987 AL554743 
    BQ186794 BG950017 AW899522 BQ881997 BM016847 BI019864 AA197253 BG978360 
    BG978713 CD630462 BQ346183 AW138656 CO245103 R47284 BE837548 D60506 
    AI902380 R68713 AW952121 AA197254 T71651 AW578511 CO248355 BG013616 
    W56105 BG954059 BE697903 BE812281 D60735 AA058747 BG949999 BE903331 
    AW956267 AA326742 BQ322393 R53402 M62229 BI767770 D60736 CD630461 
    BE541326 BF516005 CD630453 BE183281 T82074 AW749236 BE066411 BQ355614 
    R22488 CD630454 AW753833 BX435595 BF355798 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                      -     -     -                             -                             -                       -                 -   
    SP2:                                                                                -                             -                       -                 -   
    SP3:                                      -     -     -                             -     -     -     -     -     -                       -                 -   
    SP4:                                      -     -     -                             -     -     -                 -                       -                 -   
    SP5:                                                                                -                             -                       -                 -   

    ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                      -         
    SP2:                                                                                      -         
    SP3:                                                                                      -         
    SP4:  -     -     -                                                                       -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CALCOCO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALCOCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGAAATA
    CALCOCO1 Expression
    About this image


    See CALCOCO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALCOCO1

    SOURCE GeneReport for Unigene cluster: Hs.156667
        SABiosciences Custom PCR Arrays for CALCOCO1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CALCOCO1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcoco11 , 5 calcium binding and coiled coil domain 11, 5 87.94(n)1
    89.29(a)1
      15 (57.81 cM)5
    674881  NM_026192.31  NP_080468.11 
     1027067795 
    lizard
    (Anolis carolinensis)
    Reptilia CALCOCO16
    calcium binding and coiled-coil domain 1
    56(a)
    1 ↔ 1
    2(72772605-72806632)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981952 nuclear domain-10 protein NDP52 72.1(n)    AF312719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC051625.12   -- 75.69(n)   386968  BC051625.1 


    ENSEMBL Gene Tree for CALCOCO1 (if available)
    TreeFam Gene Tree for CALCOCO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALCOCO1 gene
    CALCOCO22  TAX1BP12  
    3 SIMAP similar genes for CALCOCO1 using alignment to 11 protein entries:     CACO1_HUMAN (see all proteins):
    DKFZp686A11272    TAX1BP1    CALCOCO2

    CALCOCO1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 SNPs in CALCOCO1 are shown (see all 436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114846711,2
    C,F--54104430(+) AACAGA/CAACAG 3 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs796264481,2
    C,F--54104444(+) GAATAT/AAAAAT 3 -- ds50012Minor allele frequency- A:0.02WA NA 238
    rs3750648821,2
    C--54104581(+) TTCTCA/GGCAGT 3 -- ds50010--------
    rs767452181,2
    C,F--54104686(+) ACTGCC/TGCATT 3 -- ds50012Minor allele frequency- T:0.09NA EA 240
    rs1471395111,2
    --54104877(+) TGATAA/CGAACA 3 -- ds50010--------
    rs1881747641,2
    --54104925(+) ATTTGC/TTCAAA 3 -- ut31 nc-transcript-variant0--------
    rs1929242141,2
    --54104960(+) GAAGCC/TTTTAT 3 -- ut31 nc-transcript-variant0--------
    rs1154448231,2
    C,F--54104997(+) GGGGGC/GCTTGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.28WA 118
    rs610981751,2
    C,F--54105038(+) CCCATT/CCCTCA 3 -- nc-transcript-variantut313Minor allele frequency- C:0.26CSA WA 122
    rs37416621,2
    C,F,H--54105074(-) CTCACA/GTGGAA 3 -- nc-transcript-variantut31 ese322Minor allele frequency- G:0.13NS EA NA WA CSA 2260

    HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALCOCO1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCOCO1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCOCO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for CALCOCO1:    About MalaCards
    sarcoma    panic disorder    breast cancer


    CALCOCO1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CALCOCO1
    Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

    Export disorders for CALCOCO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALCOCO1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CALCOCO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (2009)
    4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4 Haiman C.A....Press M.F. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)1, 9 Takahashi K....Ingi T. (2004)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57658 HGNC: 29306 AceView: KIAA1536 Ensembl:ENSG00000012822 euGenes: HUgn57658
    ECgene: CALCOCO1 H-InvDB: CALCOCO1

    (According to HUGE)
    About This Section
    HUGE: KIAA1536

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALCOCO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALCOCO1 gene:
    Search GeneIP for patents involving CALCOCO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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