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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALCOCO1 Gene

protein-coding GIFtS: 51
GCID: GC12M054105

calcium binding and coiled-coil domain 1

Explore 4 diseases affiliated with
CALCOCO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calcium Binding And Coiled-Coil Domain 1¹ ²		Sarcoma Antigen NY-SAR-3² ³
Cocoa¹ ²		Calcium-Binding And Coiled-Coil Domain-Containing Protein 1²
Calphoglin³		Coiled-Coil Leucine Zipper Coactivator 1²
KIAA1536¹ ³		Inorganic Pyrophosphatase Activator²
Coiled-Coil Coactivator Protein² ³		Calphoglin³

External Ids:	HGNC: 29306¹	Entrez Gene: 57658²	Ensembl: ENSG00000012822⁷	UniProtKB: Q9P1Z2³

ORGUL members:
	NONCODE:n407142

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through

its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or

coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding

proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the

Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its

interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization

of two different activation regions (By similarity)

Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as

component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose

metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

Gene Wiki entry for CALCOCO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
COUP-TF1 FOXF2 COUP HNF-4alpha2 Gfi-1 HNF-4alpha1 Pax-3 S8 COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCOCO1 promoter sequence

Search SABiosciences Chromatin IP Primers for CALCOCO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCOCO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M054105: view genomic region (about GC identifiers)

Start:	54,104,902 bp from pter	End:	54,121,529 bp from pter
Size:	16,628 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)

Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1

Size: 691 amino acids; 77336 Da

Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of

GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By

similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)

Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;

Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090

Alternative splicing: 4 isoforms: Q9P1Z2-1 Q9P1Z2-2 Q9P1Z2-3 Q9P1Z2-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P1Z2

CALCOCO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137154.1 NP_065949.1

ENSEMBL proteins:

ENSP00000456437 ENSP00000397189 ENSP00000262059 ENSP00000447647 ENSP00000449960

ENSP00000450083 ENSP00000448621 ENSP00000447117 ENSP00000449058 ENSP00000446820

ENSP00000448026 ENSP00000450012 ENSP00000449796 ENSP00000399426

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CALCOCO1 OriGene Protein Over-expression Lysate: CALCOCO1 OriGene Custom Protein Services for CALCOCO1
	GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
	Novus Biologicals CALCOCO1 Protein Novus Biologicals CALCOCO1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CALCOCO1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

CALCOCO1 for ontologies About GeneDecksing

CALCOCO1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CALCOCO1
	GenScript Custom Superior Antibodies Services for CALCOCO1
	Novus Biologicals CALCOCO1 Antibodies
	Search for Antibodies for CALCOCO1 at Abcam
	Uscn Antibodies for CALCOCO1
	Search ThermoFisher Antibodies for CALCOCO1

Assay Products for CALCOCO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALCOCO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALCOCO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALCOCO1 for domains About GeneDecksing

1 InterPro domain/family:

IPR012852 CoCoA

Graphical View of Domain Structure for InterPro Entry Q9P1Z2

ProtoNet protein and cluster: Q9P1Z2

1 Blocks protein family: IPB012852 Coiled-coil transcriptional coactivator-like

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator

function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)

Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated

transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By

similarity)

Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160

coactivators (By similarity)

Similarity: Belongs to the CALCOCO family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through

its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or

coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding

proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the

Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its

interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization

of two different activation regions (By similarity)

Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as

component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose

metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CALCOCO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
		hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCOCO1 (see all 7) OriGene shRNA RFP: CALCOCO1 OriGene siRNA: CALCOCO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CALCOCO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALCOCO1
		Search LifeMap BioReagents cell lines for CALCOCO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0003712	transcription cofactor activity	IDA	16344550
GO:0003713	transcription coactivator activity	ISS	--
GO:0005515	protein binding	IPI	16344550
GO:0008013	beta-catenin binding	IPI	16344550

CALCOCO1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Calcoco1^tm1Lex for CALCOCO1
     1 MGI phenotypic allele

for Calcoco1 (no phenotypes)

CALCOCO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CALCOCO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/44 Interacting proteins for CALCOCO1 (Q9P1Z2^{2, 3} ENSP00000262059⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	ISS	--
GO:0007165	signal transduction	ISS	--
GO:0016055	Wnt receptor signaling pathway	IEA	--
GO:0030518	intracellular steroid hormone receptor signaling pathway	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	IMP	16344550

CALCOCO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CALCOCO1

1 HMDB Compound for CALCOCO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CALCOCO1 / CACO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts):

NM_001143682.1 NM_020898.2

Unigene Cluster for CALCOCO1:

Calcium binding and coiled-coil domain 1

Hs.156667 [show with all ESTs]

Unigene Representative Sequence: AF370415

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)

ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)

ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619

ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177

ENST00000552623 ENST00000549349

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CALCOCO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
		hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCOCO1 (see all 7) OriGene shRNA RFP: CALCOCO1 OriGene siRNA: CALCOCO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCOCO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALCOCO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

Additional cDNA sequence:

AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1

AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1

CR533567.1 NR_026554.1

24 DOTS entries:

DT.95304157 DT.417860 DT.95237851 DT.40296235 DT.91758204 DT.121124009 DT.100828568 DT.100828563

DT.100828566 DT.91710713 DT.95237849 DT.121123986 DT.121124011 DT.121124014 DT.91758207 DT.91758212

DT.91758213 DT.95228852 DT.100828572 DT.121123989 DT.91758216 DT.99969194 DT.100828561 DT.121123975

397 AceView cDNA sequences (see top 24):

AL546118 BC003177 CA394013 BE220385 CA439740 BQ007149 BX441267 AI796841

W52224 BQ774442 BQ899098 AI693806 AK027881 BQ954329 AA338669 CA437503

AY358397 AA913672 BQ026889 AW513707 AB040969 BM711961 AW273283 AI347694

T17140 AI623430 CA445783 AI814511 AI758628 BU509166 CR598215 AA338668

AL539536 AI222561 AA699848 CF125303 AI270433 BM694497 AL136895 CA413354

BU175677 AA449488 T29986 BP357445 BM914308 CD630458 BM975956 BM467220

AA322811 CR597517 AW769680 AI625296 AW069584 BQ220635 BU557143 AI284738

BQ072576 AI278925 AA486443 AW204733 BQ004571 CA443598 CD365444 AU280757

BX479939 CB141179 BE736205 AI143576 CD723746 BG423110 AI635256 AW614496

AA333191 AY211909 BU615837 AI823604 CD517431 NM_020898 AI690601 AW468451

BP335596 BI711426 AI216118 BE336737 BG913313 BM906296 CB266515 R71399

BF001330 BX479940 BX417577 CR533567 AI279605 BE675160 CO246143 AI956118

CF132510 AI002424 BX491979 BQ019869 BG335865 BQ717762 BG768447 AW905049

BM543834 AX747731 BP358502 BG253637 CK003719 BQ067321 AI394073 AF370415

AV692500 BE336817 BE393640 W74596 AI684239 BQ878854 AW204364 BM970508

BG708909 BM738840 CO245451 AI435230 BI856204 BE674073 AI032429 R70184

AI820025 BQ226622 AL534831 AI052030 BG110227 BM917139 CD630457 AA412555

BI824665 AA449655 AL553166 BX462598 AI656817 CO400209 AA448358 AA404357

CD630459 AA403094 CA444304 AA918815 CB854420 BE221437 BG027867 AA678669

BQ067598 CD673306 AI949970 BI546817 AW268866 BF345328 CD366757 BP362824

BX646117 BU177030 AI433186 BE502977 BE646649 BE873522 AL534832 BG480069

BX496454 AI383820 AI689275 BI868858 BX417990 W32445 BG393503 BM804376

CF619431 BG702586 BF970513 BG982545 AA115705 CO248660 AK092788 AA340064

BP335668 BQ006482 BG740281 BX417050 CB994493 BX414205 AK122773 BM545300

BG546008 CD556532 BF757309 AI636377 BG913116 Z19145 AL041533 AI673042

BM751046 CD365850 BX538208 BG911367 CA439304 AA857400 CB963824 AI057122

BX442601 AI598090 BU731112 BE832258 BG481452 AI669311 AI559819 AW206064

AA588340 BM805636 BQ232541 BP356583 AI832804 AW863792 CO249343 BE158919

AI832884 T66797 BX408704 CO245491 BG055775 AI927979 R98647 BF678910

AV656372 BG387218 R98648 AA115704 AJ707440 R53615 W19248 BX490967

BF092639 AW001295 AA227618 AI446160 AI016093 AI926053 BU621444 R68661

BE311616 CD630464 BE206122 W45019 CD630460 CO245181 AW749238 BQ305186

BI667381 CB851214 BX344270 BP359420 AA322890 AA057304 AI436598 AL577459

BG998411 BF960790 BE244225 AI051044 BF913239 W44384 C15956 AA227933

BX471985 BI836442 H25688 BX491987 BQ582145 H26270 N89933 BG002406

AA326259 BI057248 AL525340 H51450 CD630455 BG998683 BF761922 BX344269

BQ367098 AA694598 BE770840 BE168507 BI047821 AA705325 BE770825 BF948714

BI044570 BM988327 AI493866 BF316346 AL525380 BF093608 T66796 BI462569

BM013364 AI674438 AA536083 BX407600 AA318176 BE266811 BG823417 CD630463

BE247207 CK724876 BQ214957 BF433503 AL702258 AL706439 BI047456 AA326758

BE206206 R51945 AW206965 AA037652 W44323 AL576342 BG480631 AV723315

AW899522 BG950017 BM914291 H25103 BQ881997 BF833833 BF325711 AW840176

T90545 BX407601 AA730987 BF887569 AL554743 BG943548 CD630456 AW749419

BF941302 AA677958 BQ186794 AW189961 CO245103 AW138656 BE837548 BG978713

BM016847 R47284 T71651 CO248355 AW952121 AA197253 AA197254 CD630462

BG978360 BI019864 BQ346183 AW578511 R68713 D60506 AI902380 BG954059

BQ322393 BG013616 BE903331 D60736 BI767770 AA326742 BE812281 AA058747

M62229 D60735 BG949999 AW956267 W56105 BE697903 R53402 BE541326

BF516005 CD630453 AW749236 BE066411 BQ355614 BE183281 R22488 T82074

CD630454 CD630461 BX435595 BF355798 AW753833

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14a	·	14b	^
SP1:													-		-		-										-										-								-						-
SP2:																											-										-								-						-
SP3:													-		-		-										-		-		-		-		-		-								-						-
SP4:													-		-		-										-		-		-						-								-						-
SP5:																											-										-								-						-

ExUns:	15a	·	15b	·	15c	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23
SP1:																													-
SP2:																													-
SP3:																													-
SP4:	-		-		-																								-
SP5:

ECgene alternative splicing isoforms for CALCOCO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALCOCO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGAAATA

About this image
See CALCOCO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALCOCO1

SOURCE GeneReport for Unigene cluster: Hs.156667

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CALCOCO1 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Calcoco1^{1 , 5}	calcium binding and coiled coil domain 1^{1, 5}	87.94(n)¹ 89.29(a)¹		15 (57.81 cM)⁵ 67488¹ NM_026192.3¹ NP_080468.1¹ 102706779⁵
lizard (Anolis carolinensis)	Reptilia	CALCOCO1⁶	--	57(a)	1 ↔ 1	2(72777087-72799516)
African clawed frog (Xenopus laevis)	Amphibia	LOC398195²	nuclear domain-10 protein NDP52	72.1(n)		AF312719.1
zebrafish (Danio rerio)	Actinopterygii	BC051625.1²	--	75.69(n)		386968 BC051625.1

ENSEMBL Gene Tree for CALCOCO1 (if available)
TreeFam Gene Tree for CALCOCO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CALCOCO1 gene

CALCOCO2² TAX1BP1²

3 SIMAP similar genes for CALCOCO1 using alignment to 12 protein entries: CACO1_HUMAN (see all proteins):

DKFZp686A11272 TAX1BP1 CALCOCO2

CALCOCO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111484671^1,2		--	54104430(+)	`AACAGA/CAACAG`	3	--	ds500¹		2		CSA WA	120
rs79626448^1,2	C,F,	--	54104444(+)	`GAATAT/AAAAAT`	3	--	ds500¹		2		WA NA	238
rs76745218^1,2	F,	--	54104686(+)	`ACTGCC/TGCATT`	3	--	ds500¹		2		NA EA	240
rs147139511^1,2		--	54104877(+)	`TGATAA/CGAACA`	3	--	ds500¹		0	--	--	--	--
rs188174764^1,2		--	54104925(+)	`ATTTGC/TTCAAA`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs192924214^1,2		--	54104960(+)	`GAAGCC/TTTTAT`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs115444823^1,2	F,	--	54104997(+)	`GGGGGC/GCTTGG`	3	--	nc-transcript-variantut3¹		1		WA	118
rs61098175^1,2	C,F,	--	54105038(+)	`CCCATT/CCCTCA`	3	--	nc-transcript-variantut3¹		3		CSA WA	122
rs3741662^1,2	C,F,H,	--	54105074(-)	`CTCACA/GTGGAA`	3	--	nc-transcript-variantut3¹ ese³		22		NS EA NA WA CSA	2260
rs182375472^1,2		--	54105086(+)	`AGATGC/TGAGGA`	3	--	nc-transcript-variantut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALCOCO1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CALCOCO1 for disorders About GeneDecksing

4 diseases for CALCOCO1: About MalaCards

sarcoma panic disorder breast cancer ataxia

Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

Export disorders for CALCOCO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CALCOCO1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with CALCOCO1)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Immunomic analysis of human sarcoma. (PubMed id 12601173)^{1, 2} Lee S.-Y.... Scanlan M.J. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)^{1, 9} Takahashi K....Ingi T. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)¹ Persaud A....Rotin D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57658	HGNC: 29306	AceView: KIAA1536	Ensembl:ENSG00000012822	euGenes: HUgn57658
ECgene: CALCOCO1	H-InvDB: CALCOCO1

(According to HUGE)
About This Section

HUGE: KIAA1536

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CALCOCO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CALCOCO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CALCOCO1 gene:
Search GeneIP for patents involving CALCOCO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CALCOCO1 Gene

calcium binding and coiled-coil domain 1

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CALCOCO1 Gene

calcium binding and coiled-coil domain 1

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