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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALCOCO1 Gene

protein-coding   GIFtS: 51
GCID: GC12M054105

calcium binding and coiled-coil domain 1
 Explore 4 diseases affiliated with
CALCOCO1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CALCOCO1    

Aliases
for CALCOCO1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calcium Binding And Coiled-Coil Domain 11 2     Sarcoma Antigen NY-SAR-32 3
Cocoa1 2     Calcium-Binding And Coiled-Coil Domain-Containing Protein 12
Calphoglin3     Coiled-Coil Leucine Zipper Coactivator 12
KIAA15361 3     Inorganic Pyrophosphatase Activator2
Coiled-Coil Coactivator Protein2 3     Calphoglin3

External Ids:    HGNC: 293061   Entrez Gene: 576582   Ensembl: ENSG000000128227   UniProtKB: Q9P1Z23   
ORGUL members:         
NONCODE:n407142    

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142


Summaries
for CALCOCO1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through
its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or
coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization
of two different activation regions (By similarity)
Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

Gene Wiki entry for CALCOCO1


Genomic Views
for CALCOCO1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   Gfi-1   HNF-4alpha1   Pax-3   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCOCO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALCOCO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCOCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054105:  view genomic region     (about GC identifiers)

Start:
 54,104,902 bp from pter      End:
 54,121,529 bp from pter
Size:
 16,628 bases      Orientation:
 minus strand

Proteins
for CALCOCO1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)
Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1  
Size: 691 amino acids; 77336 Da
Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of
GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By
similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)
Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;
Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090
Alternative splicing: 4 isoforms:  Q9P1Z2-1   Q9P1Z2-2   Q9P1Z2-3   Q9P1Z2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P1Z2

    • CALCOCO1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137154.1  NP_065949.1  

    ENSEMBL proteins: 
     ENSP00000456437   ENSP00000397189   ENSP00000262059   ENSP00000447647   ENSP00000449960  
     ENSP00000450083   ENSP00000448621   ENSP00000447117   ENSP00000449058   ENSP00000446820  
     ENSP00000448026   ENSP00000450012   ENSP00000449796   ENSP00000399426  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CALCOCO1
    OriGene Protein Over-expression Lysate: CALCOCO1
    OriGene Custom Protein Services for CALCOCO1 
    GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
    Novus Biologicals CALCOCO1 Protein
    Novus Biologicals CALCOCO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CALCOCO1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    CALCOCO1 for ontologies           About GeneDecksing



    CALCOCO1 Antibody Products: 
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    Novus Biologicals CALCOCO1 Antibodies
    Search for Antibodies for CALCOCO1 at Abcam  
    Uscn Antibodies for CALCOCO1
    Search ThermoFisher Antibodies for CALCOCO1

    Assay Products for CALCOCO1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CALCOCO1

    Protein Domains /
    Families
    for CALCOCO1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CALCOCO1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q9P1Z2

    ProtoNet protein and cluster: Q9P1Z2

    1 Blocks protein family: IPB012852 Coiled-coil transcriptional coactivator-like

    UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator
    function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)
    Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated
    transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By
    similarity)
    Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160
    coactivators (By similarity)
    Similarity: Belongs to the CALCOCO family


    Function
    for CALCOCO1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through
    its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or
    coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
    proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
    Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
    interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization
    of two different activation regions (By similarity)
    Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
    component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
    metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CALCOCO1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CALCOCO1

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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003712transcription cofactor activity IDA16344550
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI16344550
    GO:0008013beta-catenin binding IPI16344550


    CALCOCO1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Calcoco1tm1Lex for CALCOCO1
         1 MGI phenotypic allele for Calcoco1 (no phenotypes)

    CALCOCO1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CALCOCO1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALCOCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/44 Interacting proteins for CALCOCO1 (Q9P1Z22, 3 ENSP000002620594) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ISS--
    GO:0007165signal transduction ISS--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-dependent IMP16344550


    CALCOCO1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CALCOCO1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALCOCO1

    1 HMDB Compound for CALCOCO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CALCOCO1 / CACO1 

    Transcripts
    for CALCOCO1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts): 
    NM_001143682.1  NM_020898.2  

    Unigene Cluster for CALCOCO1:

    Calcium binding and coiled-coil domain 1
    Hs.156667  [show with all ESTs]
    Unigene Representative Sequence: AF370415
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)
    ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)
    ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619
    ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177
    ENST00000552623 ENST00000549349

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCOCO1 (see all 7)
    OriGene shRNA RFP: CALCOCO1
    OriGene siRNA: CALCOCO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

    Additional cDNA sequence: 

    AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1 
    AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1 
    CR533567.1 NR_026554.1 

    24 DOTS entries:

    DT.95304157  DT.417860  DT.95237851  DT.40296235  DT.91758204  DT.121124009  DT.100828568  DT.100828563 
    DT.100828566  DT.91710713  DT.95237849  DT.121123986  DT.121124011  DT.121124014  DT.91758207  DT.91758212 
    DT.91758213  DT.95228852  DT.100828572  DT.121123989  DT.91758216  DT.99969194  DT.100828561  DT.121123975 

    24/397 AceView cDNA sequences (see all 397):

    AL546118 BC003177 CA394013 BE220385 CA439740 BQ007149 BX441267 AI796841 
    W52224 BQ774442 BQ899098 AI693806 AK027881 BQ954329 AA338669 CA437503 
    AY358397 AA913672 BQ026889 AW513707 AB040969 BM711961 AW273283 AI347694 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                      -     -     -                             -                             -                       -                 -   
    SP2:                                                                                -                             -                       -                 -   
    SP3:                                      -     -     -                             -     -     -     -     -     -                       -                 -   
    SP4:                                      -     -     -                             -     -     -                 -                       -                 -   
    SP5:                                                                                -                             -                       -                 -   

    ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                      -         
    SP2:                                                                                      -         
    SP3:                                                                                      -         
    SP4:  -     -     -                                                                       -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CALCOCO1

    Expression
    for CALCOCO1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALCOCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CALCOCO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALCOCO1

    SOURCE GeneReport for Unigene cluster: Hs.156667
        SABiosciences Custom PCR Arrays for CALCOCO1
    Primer
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    Orthologs
    for CALCOCO1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CALCOCO1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Calcoco11 , 5 calcium binding and coiled coil domain 11, 5 87.94(n)1
    89.29(a)1    		   15 (57.81 cM)5
    674881  NM_026192.31  NP_080468.11 
     1027067795 
    lizard
    (Anolis carolinensis)    		 Reptilia CALCOCO16
    		 --
    		 57(a)
    		 1 ↔ 1
    		 2(72777087-72799516)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3981952 nuclear domain-10 protein NDP52 72.1(n)    AF312719.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC051625.12   -- 75.69(n)   386968  BC051625.1 


    ENSEMBL Gene Tree for CALCOCO1 (if available)
    TreeFam Gene Tree for CALCOCO1 (if available) 

    Paralogs
    for CALCOCO1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALCOCO1 gene
    CALCOCO22  TAX1BP12  
    3 SIMAP similar genes for CALCOCO1 using alignment to 12 protein entries:     CACO1_HUMAN (see all proteins):
    DKFZp686A11272    TAX1BP1    CALCOCO2

    CALCOCO1 for paralogs           About GeneDecksing



    Genomic Variants
    for CALCOCO1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 NCBI SNPs in CALCOCO1 are shown (see all 328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1114846711,2
    		--54104430(+) AACAGA/CAACAG 3 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs796264481,2
    		C,F,--54104444(+) GAATAT/AAAAAT 3 -- ds50012Minor allele frequency- A:0.02WA NA 238
    rs767452181,2
    		F,--54104686(+) ACTGCC/TGCATT 3 -- ds50012Minor allele frequency- T:0.09NA EA 240
    rs1471395111,2
    		--54104877(+) TGATAA/CGAACA 3 -- ds50010--------
    rs1881747641,2
    		--54104925(+) ATTTGC/TTCAAA 3 -- ut31 nc-transcript-variant0--------
    rs1929242141,2
    		--54104960(+) GAAGCC/TTTTAT 3 -- nc-transcript-variantut310--------
    rs1154448231,2
    		F,--54104997(+) GGGGGC/GCTTGG 3 -- nc-transcript-variantut311Minor allele frequency- G:0.28WA 118
    rs610981751,2
    		C,F,--54105038(+) CCCATT/CCCTCA 3 -- nc-transcript-variantut313Minor allele frequency- C:0.26CSA WA 122
    rs37416621,2
    		C,F,H,--54105074(-) CTCACA/GTGGAA 3 -- nc-transcript-variantut31 ese322Minor allele frequency- G:0.13NS EA NA WA CSA 2260
    rs1823754721,2
    		--54105086(+) AGATGC/TGAGGA 3 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CALCOCO1: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CALCOCO1

    Disorders / Diseases
    for CALCOCO1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CALCOCO1 for disorders           About GeneDecksing

    4 diseases for CALCOCO1:    About MalaCards
    sarcoma    panic disorder    breast cancer    ataxia

    Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

    Export disorders for CALCOCO1 gene to outside databases

    Publications
    for CALCOCO1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALCOCO1 gene, integrated from 9 sources (see all 31) (see top 10):
    (articles sorted by number of sources associating them with CALCOCO1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)1, 9 Takahashi K....Ingi T. (2004)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    11. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1 Haiman C.A....Press M.F. (2009)
    12. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1 Otowa T....Okazaki Y. (2009)
    13. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    14. Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin. (PubMed id 16931570)1 Yang C.K....Stallcup M.R. (2006)
    15. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    16. Downstream signaling mechanism of the C-terminal acti vation domain of transcriptional coactivator CoCoA. (PubMed id 16717280)1 Kim J.H....Stallcup M.R. (2006)
    17. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    18. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. (PubMed id 16344550)1 Yang C.K....Stallcup M.R. (2006)
    19. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    20. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    21. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    22. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PubMed id 15851553)1 Ozyildirim A.M....Laurie G.W. (2005)
    23. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
    24. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    25. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    27. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    28. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
    29. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    30. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    External Searches for CALCOCO1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CALCOCO1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57658 HGNC: 29306 AceView: KIAA1536 Ensembl:ENSG00000012822 euGenes: HUgn57658
    ECgene: CALCOCO1 H-InvDB: CALCOCO1

    Other Databases showing CALCOCO1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1536

    Specialized Databases showing CALCOCO1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALCOCO1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CALCOCO1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CALCOCO1 gene:
    Search GeneIP for patents involving CALCOCO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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