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CALCOCO1 Gene

protein-coding   GIFtS: 53
GCID: GC12M054105

Calcium Binding And Coiled-Coil Domain 1
  See related diseases
at
MalaCards
 

Aliases
for CALCOCO1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding And Coiled-Coil Domain 11 2     Cocoa2
Coiled-Coil Leucine Zipper Coactivator 11 2     Calcium-Binding And Coiled-Coil Domain-Containing Protein 12
Inorganic Pyrophosphatase Activator1 2     calphoglin2
Coiled-Coil Coactivator Protein2 3     Calphoglin3
Sarcoma Antigen NY-SAR-32 3     KIAA15363

External Ids:    HGNC: 293061   Entrez Gene: 576582   Ensembl: ENSG000000128227   UniProtKB: Q9P1Z23   

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142


Summaries
for CALCOCO1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALCOCO1 Gene:
CALCOCO1 (calcium binding and coiled-coil domain 1) is a protein-coding gene. Diseases associated with CALCOCO1 include sarcoma, and panic disorder. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
utilization of two different activation regions (By similarity)
Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
growth

Gene Wiki entry for CALCOCO1 Gene


Genomic Views
for CALCOCO1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   Gfi-1   HNF-4alpha1   Pax-3   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCOCO1 promoter sequence
   Search Chromatin IP Primers for CALCOCO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCOCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054105:  view genomic region     (about GC identifiers)

Start:
 54,104,902 bp from pter      End:
 54,121,529 bp from pter
Size:
 16,628 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CALCOCO1

Proteins
for CALCOCO1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)
Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1  
Size: 691 amino acids; 77336 Da
Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of
GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By
similarity)
Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;
Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090
Alternative splicing: 4 isoforms:  Q9P1Z2-1   Q9P1Z2-2   Q9P1Z2-3   Q9P1Z2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Explore proteomics data for CALCOCO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See CALCOCO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137154.1  NP_065949.1  

    ENSEMBL proteins: 
     ENSP00000456437   ENSP00000397189   ENSP00000262059   ENSP00000447647   ENSP00000449960  
     ENSP00000450083   ENSP00000448621   ENSP00000447117   ENSP00000449058   ENSP00000446820  
     ENSP00000448026   ENSP00000450012   ENSP00000449796  

    CALCOCO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALCOCO1
    OriGene Protein Over-expression Lysate for CALCOCO1
    OriGene MassSpec for CALCOCO1
    OriGene Custom Protein Services for CALCOCO1
    GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
    Novus Biologicals CALCOCO1 Protein
    Novus Biologicals CALCOCO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALCOCO1

    CALCOCO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CALCOCO1
    Novus Biologicals CALCOCO1 Antibodies
    Abcam antibodies for CALCOCO1
    Cloud-Clone Corp. Antibodies for CALCOCO1
    ThermoFisher Antibodies for CALCOCO1
    LSBio Antibodies in human, mouse, rat for CALCOCO1

    CALCOCO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALCOCO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALCOCO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALCOCO1
    Cloud-Clone Corp. CLIAs for CALCOCO1

    Domains /
    Families
    for CALCOCO1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 1 InterPro protein domain:
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q9P1Z2

    ProtoNet protein and cluster: Q9P1Z2

    1 Blocks protein domain: IPB012852 Coiled-coil transcriptional coactivator-like

    UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2
    Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for
    coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)
    Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of
    LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic
    cooperation (By similarity)
    Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160
    coactivators (By similarity)
    Similarity: Belongs to the CALCOCO family


    CALCOCO1 for domains           About GeneDecksing


    Function
    for CALCOCO1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACO1_HUMAN, Q9P1Z2
    Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters
    through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors
    or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding
    proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the
    Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its
    interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential
    utilization of two different activation regions (By similarity)
    Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as
    component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose
    metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell
    growth

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003712transcription cofactor activity IDA16344550
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding IPI16344550
    GO:0008013beta-catenin binding IPI16344550
         
    CALCOCO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Calcoco1 (no phenotypes)

    CALCOCO1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calcoco1tm1Lex for CALCOCO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALCOCO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALCOCO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCOCO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCOCO1

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for CALCOCO1
    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CALCOCO1

    Clone
    Products:             		 OriGene clones in human, mouse for CALCOCO1 (see all 11)
    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    Sino Biological Human cDNA Clone for CALCOCO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CALCOCO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALCOCO1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1


    Localization
    for CALCOCO1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    CACO1_HUMAN, Q9P1Z2: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    CALCOCO1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for CALCOCO1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALCOCO1
    Interactions:

        GeneGlobe Interaction Network for CALCOCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CALCOCO1 (Q9P1Z22, 3 ENSP000002620594) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ISS--
    GO:0007165signal transduction ISS--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway ISS--
    GO:0045893positive regulation of transcription, DNA-templated IMP16344550

    CALCOCO1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CALCOCO1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALCOCO1 (CACO1)

    1 HMDB Compound for CALCOCO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    Transcripts
    for CALCOCO1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts): 
    NM_001143682.1  NM_020898.2  

    Unigene Cluster for CALCOCO1:

    Calcium binding and coiled-coil domain 1
    Hs.156667  [show with all ESTs]
    Unigene Representative Sequence: AF370415
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)
    ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)
    ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619
    ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177
    ENST00000552623 ENST00000549349
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat CALCOCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCOCO1 (see all 12):
    hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for CALCOCO1
    Predesigned siRNA for gene silencing in human, mouse, rat CALCOCO1
    Clone
    Products:             		 OriGene clones in human, mouse for CALCOCO1 (see all 11)
    OriGene ORF clones in mouse, rat for CALCOCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for CALCOCO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCOCO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCOCO1
      QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
      QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

    Additional mRNA sequence: 

    AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1 
    AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1 
    CR533567.1 NR_026554.1 

    24 DOTS entries:

    DT.95304157  DT.417860  DT.95237851  DT.40296235  DT.91758204  DT.121124009  DT.100828568  DT.100828563 
    DT.100828566  DT.91710713  DT.95237849  DT.121123986  DT.121124011  DT.121124014  DT.91758207  DT.91758212 
    DT.91758213  DT.95228852  DT.100828572  DT.121123989  DT.91758216  DT.99969194  DT.100828561  DT.121123975 

    Selected AceView cDNA sequences (see all 397):

    CA445783 BM467220 AI693806 BQ004571 CA439740 CB141179 AI625296 AI143576 
    BQ072576 AW513707 BM711961 BG423110 BU557143 BQ026889 AI347694 CD365444 
    BQ007149 BP335596 AW468451 BP357445 AI216118 AA486443 T17140 BQ954329 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                      -     -     -                             -                             -                       -                 -   
    SP2:                                                                                -                             -                       -                 -   
    SP3:                                      -     -     -                             -     -     -     -     -     -                       -                 -   
    SP4:                                      -     -     -                             -     -     -                 -                       -                 -   
    SP5:                                                                                -                             -                       -                 -   

    ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                      -         
    SP2:                                                                                      -         
    SP3:                                                                                      -         
    SP4:  -     -     -                                                                       -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CALCOCO1

    Expression
    for CALCOCO1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALCOCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGAAATA
    CALCOCO1 Expression
    About this image


    CALCOCO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CALCOCO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    CALCOCO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156667
        Custom PCR Arrays for CALCOCO1
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    Orthologs
    for CALCOCO1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CALCOCO1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Calcoco11 , 5 calcium binding and coiled coil domain 11, 5 87.94(n)1
    89.29(a)1    		   15 (57.81 cM)5
    674881  NM_026192.31  NP_080468.11 
     1027067795 
    lizard
    (Anolis carolinensis)    		 Reptilia CALCOCO16
    		 calcium binding and coiled-coil domain 1
    		 53(a)
    		 1 ↔ 1
    		 2(72772605-72806632)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3981952 nuclear domain-10 protein NDP52 72.1(n)    AF312719.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC051625.12   -- 75.69(n)   386968  BC051625.1 


    ENSEMBL Gene Tree for CALCOCO1 (if available)
    TreeFam Gene Tree for CALCOCO1 (if available)

    Paralogs
    for CALCOCO1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALCOCO1 gene
    CALCOCO22  TAX1BP12  
    3 SIMAP similar genes for CALCOCO1 using alignment to 11 protein entries:     CACO1_HUMAN (see all proteins):
    DKFZp686A11272    TAX1BP1    CALCOCO2

    CALCOCO1 for paralogs           About GeneDecksing



    Genomic Variants
    for CALCOCO1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALCOCO1 (see all 436)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1114846711,2
    		C,F--54104430(+) AACAGA/CAACAG 3 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs796264481,2
    		C,F--54104444(+) GAATAT/AAAAAT 3 -- ds50012Minor allele frequency- A:0.02WA NA 238
    rs3750648821,2
    		C--54104581(+) TTCTCA/GGCAGT 3 -- ds50010--------
    rs767452181,2
    		C,F--54104686(+) ACTGCC/TGCATT 3 -- ds50012Minor allele frequency- T:0.09NA EA 240
    rs1471395111,2
    		--54104877(+) TGATAA/CGAACA 3 -- ds50010--------
    rs1881747641,2
    		--54104925(+) ATTTGC/TTCAAA 3 -- ut31 nc-transcript-variant0--------
    rs1929242141,2
    		--54104960(+) GAAGCC/TTTTAT 3 -- ut31 nc-transcript-variant0--------
    rs1154448231,2
    		C,F--54104997(+) GGGGGC/GCTTGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.28WA 118
    rs610981751,2
    		C,F--54105038(+) CCCATT/CCCTCA 3 -- nc-transcript-variantut313Minor allele frequency- C:0.26CSA WA 122
    rs37416621,2
    		C,F,H--54105074(-) CTCACA/GTGGAA 3 -- nc-transcript-variantut31 ese322Minor allele frequency- G:0.13NS EA NA WA CSA 2260

    HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALCOCO1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCOCO1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCOCO1

    Disorders / Diseases
    for CALCOCO1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for CALCOCO1:    
    About MalaCards
    sarcoma    panic disorder    biliary atresia    ataxia
    breast cancer


    CALCOCO1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CALCOCO1
    Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

    Export disorders for CALCOCO1 gene to outside databases

    Publications
    for CALCOCO1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALCOCO1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CALCOCO1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4 Haiman C.A....Press M.F. (BMC Cancer 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)1, 9 Takahashi K....Ingi T. (Biochem. Biophys. Res. Commun. 2004)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    External Searches for CALCOCO1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CALCOCO1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57658 HGNC: 29306 AceView: KIAA1536 Ensembl:ENSG00000012822 euGenes: HUgn57658
    ECgene: CALCOCO1 H-InvDB: CALCOCO1

    Other Databases showing CALCOCO1 gene

    (According to HUGE)
    About This Section

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    HUGE: KIAA1536

    Specialized Databases showing CALCOCO1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CALCOCO1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CALCOCO1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for CALCOCO1 gene:
    Search GeneIP for patents involving CALCOCO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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