Aliases for CALCOCO1 Gene
Aliases for CALCOCO1 Gene
External Ids for CALCOCO1 Gene
- HGNC: 29306
- Entrez Gene: 57658
- Ensembl: ENSG00000012822
- UniProtKB: Q9P1Z2
Previous GeneCards Identifiers for CALCOCO1 Gene
- GC12M052392
- GC12M054105
- GC12M051142
Summaries for CALCOCO1 Gene
GeneCards Summary for CALCOCO1 Gene
CALCOCO1 (Calcium Binding And Coiled-Coil Domain 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAX1BP1.
UniProtKB/Swiss-Prot for CALCOCO1 Gene
-
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
-
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCOCO1 Gene
Genomics for CALCOCO1 Gene
Regulatory Elements for CALCOCO1 Gene
Enhancers for CALCOCO1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CALCOCO1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CALCOCO1 gene promoter:
Regulatory Element Products
Genomic Location for CALCOCO1 Gene
- Chromosome:
- 12
- Start:
- 53,708,517 bp from pter
- End:
- 53,727,745 bp from pter
- Size:
- 19,229 bases
- Orientation:
- Minus strand
Genomic View for CALCOCO1 Gene
Genes around CALCOCO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
CALCOCO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALCOCO1 Gene
Proteins for CALCOCO1 Gene
-
Protein details for CALCOCO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P1Z2-CACO1_HUMAN
- Recommended name:
- Calcium-binding and coiled-coil domain-containing protein 1
- Protein Accession:
- Q9P1Z2
- B3KVA8
- Q6FI59
- Q71RC3
- Q86WF8
- Q96JU3
- Q9H090
Protein attributes for CALCOCO1 Gene
- Size:
- 691 amino acids
- Molecular mass:
- 77336 Da
- Quaternary structure:
-
- Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref.1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA96060.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CALCOCO1 Gene
Post-translational modifications for CALCOCO1 Gene
Other Protein References for CALCOCO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CALCOCO1
- Novus Biologicals Antibodies for CALCOCO1
-
Abcam antibodies for CALCOCO1
- Invitrogen Antibodies for CALCOCO1
- antibodies-online Antibodies for CALCOCO1: See all 10
- GeneTex CALCOCO1 antibody for CALCOCO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALCOCO1
Protein Products
-
OriGene Purified Proteins for CALCOCO1
- Search Origene for MassSpec and Protein Over-expression Lysates for CALCOCO1
- Origene Custom Protein Services for CALCOCO1
- antibodies-online Proteins for CALCOCO1: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CALCOCO1
-
Abcam proteins for CALCOCO1
Assay Products
- antibodies-online Kits for CALCOCO1: See all 1
No data available for DME Specific Peptides for CALCOCO1 Gene
Domains & Families for CALCOCO1 Gene
Protein Domains for CALCOCO1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CALCOCO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P1Z2UniProtKB/Swiss-Prot:
CACO1_HUMAN :- The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
- Belongs to the CALCOCO family.
- Domain:
-
- The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
- The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).
- Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.
- Family:
-
- Belongs to the CALCOCO family.
No data available for Gene Families for CALCOCO1 Gene
Function for CALCOCO1 Gene
Molecular function for CALCOCO1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
- UniProtKB/Swiss-Prot Function:
- Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001047 | core promoter binding | IDA | 24245781 |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003712 | transcription cofactor activity | IDA | 16344550 |
| GO:0003713 | transcription coactivator activity | IMP,ISS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for CALCOCO1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CALCOCO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALCOCO1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
- Search ViGene Biosciences for CALCOCO1
CRISPR Products
-
OriGene CRISPR knockouts for CALCOCO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
miRNA for CALCOCO1 Gene
- miRTarBase miRNAs that target CALCOCO1
-
- mmu-mir-466c-5p (MIRT590485)
- mmu-mir-466o-5p (MIRT590486)
- mmu-mir-466b-5p (MIRT590487)
- mmu-mir-466e-5p (MIRT590488)
- mmu-mir-466p-5p (MIRT590489)
- mmu-mir-466a-5p (MIRT590490)
- mmu-mir-1187 (MIRT590491)
- mmu-mir-466l-5p (MIRT590492)
- mmu-mir-466d-5p (MIRT590493)
- mmu-mir-466k (MIRT590494)
- mmu-mir-466i-5p (MIRT590495)
miRNA Products
- Search ViGene Biosciences for CALCOCO1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CALCOCO1
-
ViGene Biosciences adenoviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALCOCO1 Gene
Localization for CALCOCO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALCOCO1 Gene
- Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for CALCOCO1 Gene
No Data Available
Interacting Proteins for CALCOCO1 Gene
Selected Interacting proteins:
ENSP00000449960
Q9P1Z2-CACO1_HUMAN
for CALCOCO1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007165 | signal transduction | ISS | -- |
| GO:0010628 | positive regulation of gene expression | IDA | 16344550 |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CALCOCO1 Gene
Drugs & Compounds for CALCOCO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for CALCOCO1 Gene
mRNA/cDNA for CALCOCO1 Gene
- (9) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (397) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CALCOCO1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CALCOCO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
miRNA Products
- Search ViGene Biosciences for CALCOCO1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||||
| SP22: |
Expression for CALCOCO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Platelet (12.0), and Ovary (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CALCOCO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CALCOCO1 Gene:
CALCOCO1SOURCE GeneReport for Unigene cluster for CALCOCO1 Gene:
Hs.156667Evidence on tissue expression from TISSUES for CALCOCO1 Gene
- Nervous system(5)
- Kidney(4.4)
- Spleen(4.3)
- Thyroid gland(4.3)
- Lung(3.1)
- Skin(2.4)
- Intestine(2.3)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for CALCOCO1
-
OriGene qPCR primer pairs and template standards for CALCOCO1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCOCO1 Gene
Orthologs for CALCOCO1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CALCOCO1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CALCOCO1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CALCOCO1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Calcoco1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100912282 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CALCOCO1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CALCOCO1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493024 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398195 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | calcoco1a 34 35 |
|
||
| calcoco1b 35 |
|
OneToMany | |||
| -- 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.823 35 |
|
OneToMany |
- Species where no ortholog for CALCOCO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CALCOCO1 Gene
(3) SIMAP similar genes for CALCOCO1 Gene using alignment to 11 proteins:
Variants for CALCOCO1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000179222 | -- | 53,723,876(+) | CTCTT(C/T)TCCAC | intron-variant | |
| rs1000555178 | -- | 53,727,380(+) | ATCGC(A/C)CCCAA | intron-variant, upstream-variant-2KB | |
| rs1000754207 | -- | 53,727,172(+) | CGCAT(C/T)GAGAA | intron-variant, upstream-variant-2KB | |
| rs1000823828 | -- | 53,714,558(+) | GTCCT(C/T)ACCTG | intron-variant | |
| rs1000899963 | -- | 53,711,053(+) | AGAGC(C/T)GGAGG | downstream-variant-500B |
Residual Variation Intolerance Score:
45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.22;
84.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CALCOCO1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CALCOCO1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CALCOCO1 Gene
Disorders for CALCOCO1 Gene
Relevant External Links for CALCOCO1
No disorders were found for CALCOCO1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALCOCO1 Gene
Publications for CALCOCO1 Gene
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. (PMID: 24245781) Mizuta S. … Ito M. (Genes Cells 2014) 3 4 64
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman C.A. … Press M.F. (BMC Cancer 2009) 3 46 64
- Genome-wide association study of panic disorder in the Japanese population. (PMID: 19165232) Otowa T. … Okazaki Y. (J. Hum. Genet. 2009) 3 46 64
Products for CALCOCO1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for CALCOCO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CALCOCO1
- Search Origene for MassSpec and Protein Over-expression Lysates for CALCOCO1
- Origene Custom Protein Services for CALCOCO1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
- OriGene qPCR primer pairs and template standards for CALCOCO1
- OriGene qPCR primer pairs for CALCOCO1
- OriGene CRISPR knockouts for CALCOCO1
- OriGene ORF clones in human for CALCOCO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CALCOCO1
- GenScript: Next-day shipping cDNA ORF clone for CALCOCO1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
- GenScript Custom Assay Services for CALCOCO1
- GenScript Custom overexpressing Cell Line Services for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CALCOCO1
- Sino Biological Human cDNA Clone for CALCOCO1
- Browse Sino Biological Cell Lysates
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- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CALCOCO1
- Novus Biologicals proteins and lysates for CALCOCO1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CALCOCO1
- Abcam proteins for CALCOCO1
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for CALCOCO1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for CALCOCO1: See all 10
- antibodies-online Kits for CALCOCO1: See all 1
- antibodies-online Proteins for CALCOCO1: See all 6
- Search antibodies-online for peptides
- GeneTex CALCOCO1 antibody for CALCOCO1
- Search GeneTex for Proteins for CALCOCO1
- ViGene Biosciences adenoviral particle packaged cDNA for CALCOCO1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
- Search ViGene Biosciences for CALCOCO1
- Santa Cruz Biotechnology (SCBT) Antibodies for CALCOCO1
- Search Santa Cruz Biotechnology (SCBT) for CALCOCO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- Horizon Cell Lines for CALCOCO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALCOCO1
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CALCOCO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
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- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (146) Cyagen
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- (148) SNPedia
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- (155) Gene ORGANizer