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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALCOCO1 Gene

protein-coding GIFtS: 51
GCID: GC12M054105

calcium binding and coiled-coil domain 1

Explore 4 diseases affiliated with
CALCOCO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calcium Binding And Coiled-Coil Domain 1¹ ²		Sarcoma Antigen NY-SAR-3² ³
Cocoa¹ ²		Calcium-Binding And Coiled-Coil Domain-Containing Protein 1²
Calphoglin³		Coiled-Coil Leucine Zipper Coactivator 1²
KIAA1536¹ ³		Inorganic Pyrophosphatase Activator²
Coiled-Coil Coactivator Protein² ³		Calphoglin³

External Ids:	HGNC: 29306¹	Entrez Gene: 57658²	Ensembl: ENSG00000012822⁷	UniProtKB: Q9P1Z2³

ORGUL members:
	NONCODE:n407142

Export aliases for CALCOCO1 gene to outside databases

Previous GC identifers: GC12M052392 GC12M051142

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through

its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or

coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding

proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the

Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its

interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization

of two different activation regions (By similarity)

Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as

component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose

metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

Gene Wiki entry for CALCOCO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALCOCO1 gene promoter:
COUP-TF1 FOXF2 COUP HNF-4alpha2 Gfi-1 HNF-4alpha1 Pax-3 S8 COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCOCO1 promoter sequence

Search SABiosciences Chromatin IP Primers for CALCOCO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCOCO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13

CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCOCO1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M054105: view genomic region (about GC identifiers)

Start:	54,104,902 bp from pter	End:	54,121,529 bp from pter
Size:	16,628 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2 (See protein sequence)

Recommended Name: Calcium-binding and coiled-coil domain-containing protein 1

Size: 691 amino acids; 77336 Da

Subunit: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM. Interacts with the bHLH-PAS domains of

GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300 (By

similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity)

Sequence caution: Sequence=BAA96060.1; Type=Erroneous initiation;

Secondary accessions: B3KVA8 Q6FI59 Q71RC3 Q86WF8 Q96JU3 Q9H090

Alternative splicing: 4 isoforms: Q9P1Z2-1 Q9P1Z2-2 Q9P1Z2-3 Q9P1Z2-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALCOCO1: NX_Q9P1Z2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P1Z2

CALCOCO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137154.1 NP_065949.1

ENSEMBL proteins:

ENSP00000456437 ENSP00000397189 ENSP00000262059 ENSP00000447647 ENSP00000449960

ENSP00000450083 ENSP00000448621 ENSP00000447117 ENSP00000449058 ENSP00000446820

ENSP00000448026 ENSP00000450012 ENSP00000449796 ENSP00000399426

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CALCOCO1 OriGene Protein Over-expression Lysate: CALCOCO1 OriGene Custom Protein Services for CALCOCO1
	GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
	Novus Biologicals CALCOCO1 Protein Novus Biologicals CALCOCO1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CALCOCO1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

CALCOCO1 for ontologies About GeneDecksing

CALCOCO1 Antibody Products:

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	Browse OriGene Antibodies OriGene Custom Antibody Services for CALCOCO1
	GenScript Custom Superior Antibodies Services for CALCOCO1
	Novus Biologicals CALCOCO1 Antibodies
	Search for Antibodies for CALCOCO1 at Abcam
	Uscn Antibodies for CALCOCO1
	Search ThermoFisher Antibodies for CALCOCO1

Assay Products for CALCOCO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALCOCO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALCOCO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALCOCO1 for domains About GeneDecksing

1 InterPro domain/family:

IPR012852 CoCoA

Graphical View of Domain Structure for InterPro Entry Q9P1Z2

ProtoNet protein and cluster: Q9P1Z2

1 Blocks protein family: IPB012852 Coiled-coil transcriptional coactivator-like

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Domain: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator

function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity)

Domain: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated

transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By

similarity)

Domain: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160

coactivators (By similarity)

Similarity: Belongs to the CALCOCO family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CACO1_HUMAN, Q9P1Z2

Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through

its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or

coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding

proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the

Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its

interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization

of two different activation regions (By similarity)

Function: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as

component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose

metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CALCOCO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
		hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCOCO1 (see all 7) OriGene shRNA RFP: CALCOCO1 OriGene siRNA: CALCOCO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CALCOCO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALCOCO1
		Search LifeMap BioReagents cell lines for CALCOCO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0003712	transcription cofactor activity	IDA	16344550
GO:0003713	transcription coactivator activity	ISS	--
GO:0005515	protein binding	IPI	16344550
GO:0008013	beta-catenin binding	IPI	16344550

CALCOCO1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Calcoco1^tm1Lex for CALCOCO1
     1 MGI phenotypic allele

for Calcoco1 (no phenotypes)

CALCOCO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CALCOCO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/44 Interacting proteins for CALCOCO1 (Q9P1Z2^{2, 3} ENSP00000262059⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	ISS	--
GO:0007165	signal transduction	ISS	--
GO:0016055	Wnt receptor signaling pathway	IEA	--
GO:0030518	intracellular steroid hormone receptor signaling pathway	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	IMP	16344550

CALCOCO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CALCOCO1

1 HMDB Compound for CALCOCO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CALCOCO1 / CACO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALCOCO1 gene (2 alternative transcripts):

NM_001143682.1 NM_020898.2

Unigene Cluster for CALCOCO1:

Calcium binding and coiled-coil domain 1

Hs.156667 [show with all ESTs]

Unigene Representative Sequence: AF370415

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000546443 ENST00000430117 ENST00000262059(uc001sef.3 uc010som.2 uc010son.2 uc009znd.3 uc001seg.3)

ENST00000548263(uc001see.3 uc001seh.2) ENST00000550804 ENST00000549935(uc010soo.1)

ENST00000549613 ENST00000552282 ENST00000547988 ENST00000551900 ENST00000546619

ENST00000547949 ENST00000553154 ENST00000549784 ENST00000549173 ENST00000548177

ENST00000552623 ENST00000549349

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CALCOCO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCOCO1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCOCO1 (see all 12):
		hsa-miR-137 hsa-miR-487a hsa-miR-486-3p hsa-miR-4260 hsa-miR-3157-5p hsa-miR-154* hsa-miR-3605-5p hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CALCOCO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCOCO1 (see all 7) OriGene shRNA RFP: CALCOCO1 OriGene siRNA: CALCOCO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCOCO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCOCO1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CALCOCO1 (NM_001143682)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCOCO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCOCO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCOCO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALCOCO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

Additional cDNA sequence:

AB040969.1 AF370415.1 AK027881.1 AK092788.1 AK122773.1 AK222646.1 AK294424.1 AK296497.1

AK309199.1 AK315578.1 AL136895.1 AY211909.1 AY358397.1 AY563137.1 BC003177.1 BX538208.1

CR533567.1 NR_026554.1

24 DOTS entries:

DT.95304157 DT.417860 DT.95237851 DT.40296235 DT.91758204 DT.121124009 DT.100828568 DT.100828563

DT.100828566 DT.91710713 DT.95237849 DT.121123986 DT.121124011 DT.121124014 DT.91758207 DT.91758212

DT.91758213 DT.95228852 DT.100828572 DT.121123989 DT.91758216 DT.99969194 DT.100828561 DT.121123975

24/397 AceView cDNA sequences (see all 397):

AL546118 BC003177 CA394013 BE220385 CA439740 BQ007149 BX441267 AI796841

W52224 BQ774442 BQ899098 AI693806 AK027881 BQ954329 AA338669 CA437503

AY358397 AA913672 BQ026889 AW513707 AB040969 BM711961 AW273283 AI347694

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 (see all 22) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14a	·	14b	^
SP1:													-		-		-										-										-								-						-
SP2:																											-										-								-						-
SP3:													-		-		-										-		-		-		-		-		-								-						-
SP4:													-		-		-										-		-		-						-								-						-
SP5:																											-										-								-						-

ExUns:	15a	·	15b	·	15c	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23
SP1:																													-
SP2:																													-
SP3:																													-
SP4:	-		-		-																								-
SP5:

ECgene alternative splicing isoforms for CALCOCO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALCOCO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGAAATA

About this image
See CALCOCO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALCOCO1

SOURCE GeneReport for Unigene cluster: Hs.156667

SABiosciences Custom PCR Arrays for CALCOCO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCOCO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALCOCO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCOCO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCOCO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCOCO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CALCOCO1 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Calcoco1^{1 , 5}	calcium binding and coiled coil domain 1^{1, 5}	87.94(n)¹ 89.29(a)¹		15 (57.81 cM)⁵ 67488¹ NM_026192.3¹ NP_080468.1¹ 102706779⁵
lizard (Anolis carolinensis)	Reptilia	CALCOCO1⁶	--	57(a)	1 ↔ 1	2(72777087-72799516)
African clawed frog (Xenopus laevis)	Amphibia	LOC398195²	nuclear domain-10 protein NDP52	72.1(n)		AF312719.1
zebrafish (Danio rerio)	Actinopterygii	BC051625.1²	--	75.69(n)		386968 BC051625.1

ENSEMBL Gene Tree for CALCOCO1 (if available)
TreeFam Gene Tree for CALCOCO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CALCOCO1 gene

CALCOCO2² TAX1BP1²

3 SIMAP similar genes for CALCOCO1 using alignment to 12 protein entries: CACO1_HUMAN (see all proteins):

DKFZp686A11272 TAX1BP1 CALCOCO2

CALCOCO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111484671^1,2		--	54104430(+)	`AACAGA/CAACAG`	3	--	ds500¹		2		CSA WA	120
rs79626448^1,2	C,F,	--	54104444(+)	`GAATAT/AAAAAT`	3	--	ds500¹		2		WA NA	238
rs76745218^1,2	F,	--	54104686(+)	`ACTGCC/TGCATT`	3	--	ds500¹		2		NA EA	240
rs147139511^1,2		--	54104877(+)	`TGATAA/CGAACA`	3	--	ds500¹		0	--	--	--	--
rs188174764^1,2		--	54104925(+)	`ATTTGC/TTCAAA`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs192924214^1,2		--	54104960(+)	`GAAGCC/TTTTAT`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs115444823^1,2	F,	--	54104997(+)	`GGGGGC/GCTTGG`	3	--	nc-transcript-variantut3¹		1		WA	118
rs61098175^1,2	C,F,	--	54105038(+)	`CCCATT/CCCTCA`	3	--	nc-transcript-variantut3¹		3		CSA WA	122
rs3741662^1,2	C,F,H,	--	54105074(-)	`CTCACA/GTGGAA`	3	--	nc-transcript-variantut3¹ ese³		22		NS EA NA WA CSA	2260
rs182375472^1,2		--	54105086(+)	`AGATGC/TGAGGA`	3	--	nc-transcript-variantut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALCOCO1 (54104902 - 54121529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALCOCO1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CALCOCO1 for disorders About GeneDecksing

4 diseases for CALCOCO1: About MalaCards

sarcoma panic disorder breast cancer ataxia

Human Genome Epidemiology (HuGE) Navigator: CALCOCO1 (3 documents)

Export disorders for CALCOCO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CALCOCO1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with CALCOCO1)

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Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Immunomic analysis of human sarcoma. (PubMed id 12601173)^{1, 2} Lee S.-Y.... Scanlan M.J. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PubMed id 15522220)^{1, 9} Takahashi K....Ingi T. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)¹ Persaud A....Rotin D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57658	HGNC: 29306	AceView: KIAA1536	Ensembl:ENSG00000012822	euGenes: HUgn57658
ECgene: CALCOCO1	H-InvDB: CALCOCO1

(According to HUGE)
About This Section

HUGE: KIAA1536

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CALCOCO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CALCOCO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CALCOCO1 gene:
Search GeneIP for patents involving CALCOCO1

GeneCards and IP:
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calcium binding and coiled-coil domain 1

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CALCOCO1 Gene

calcium binding and coiled-coil domain 1

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