Aliases for CALCOCO1 Gene
Aliases for CALCOCO1 Gene
External Ids for CALCOCO1 Gene
- HGNC: 29306
- Entrez Gene: 57658
- Ensembl: ENSG00000012822
- UniProtKB: Q9P1Z2
Previous GeneCards Identifiers for CALCOCO1 Gene
- GC12M052392
- GC12M054105
- GC12M051142
Summaries for CALCOCO1 Gene
GeneCards Summary for CALCOCO1 Gene
CALCOCO1 (Calcium Binding And Coiled-Coil Domain 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAX1BP1.
UniProtKB/Swiss-Prot for CALCOCO1 Gene
-
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
-
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
Additional gene information for CALCOCO1 Gene
- Monarch Initiative
- Search for CALCOCO1 at DataMed
- Search for CALCOCO1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCOCO1 Gene
Genomics for CALCOCO1 Gene
GeneHancer (GH) Regulatory Elements for CALCOCO1 Gene
Promoters and enhancers for CALCOCO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CALCOCO1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CALCOCO1 gene promoter:
Regulatory Element Products
Genomic Locations for CALCOCO1 Gene
Genomic Locations for CALCOCO1 Gene
- chr12:53,708,517-53,727,745
- (GRCh38/hg38)
- Size:
- 19,229 bases
- Orientation:
- Minus strand
- chr12:54,104,902-54,121,529
- (GRCh37/hg19)
Genomic View for CALCOCO1 Gene
Genes around CALCOCO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
CALCOCO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALCOCO1 Gene
Proteins for CALCOCO1 Gene
-
Protein details for CALCOCO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P1Z2-CACO1_HUMAN
- Recommended name:
- Calcium-binding and coiled-coil domain-containing protein 1
- Protein Accession:
- Q9P1Z2
- B3KVA8
- Q6FI59
- Q71RC3
- Q86WF8
- Q96JU3
- Q9H090
Protein attributes for CALCOCO1 Gene
- Size:
- 691 amino acids
- Molecular mass:
- 77336 Da
- Quaternary structure:
-
- Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref.1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA96060.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CALCOCO1 Gene
Post-translational modifications for CALCOCO1 Gene
No Post-translational modifications
Other Protein References for CALCOCO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CALCOCO1
- Novus Biologicals Antibodies for CALCOCO1
-
Abcam antibodies for CALCOCO1
- Invitrogen Antibodies for CALCOCO1
- GeneTex CALCOCO1 antibody for CALCOCO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALCOCO1
Protein Products
-
OriGene Purified Proteins for CALCOCO1
- Search Origene for MassSpec and Protein Over-expression Lysates for CALCOCO1
- Origene Custom Protein Services for CALCOCO1
- Search GeneTex for Proteins for CALCOCO1
-
Abcam proteins for CALCOCO1
Assay Products
No data available for DME Specific Peptides for CALCOCO1 Gene
Domains & Families for CALCOCO1 Gene
Gene Families for CALCOCO1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CALCOCO1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CALCOCO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P1Z2UniProtKB/Swiss-Prot:
CACO1_HUMAN :- The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
- Belongs to the CALCOCO family.
- Domain:
-
- The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
- The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).
- Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.
- Family:
-
- Belongs to the CALCOCO family.
Function for CALCOCO1 Gene
Molecular function for CALCOCO1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
- UniProtKB/Swiss-Prot Function:
- Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
Phenotypes From GWAS Catalog for CALCOCO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001047 | core promoter binding | IDA | 24245781 |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003712 | transcription cofactor activity | IDA | 16344550 |
| GO:0003713 | transcription coactivator activity | ISS,IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for CALCOCO1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALCOCO1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
- Search ViGene Biosciences for CALCOCO1
CRISPR Products
-
OriGene CRISPR knockouts for CALCOCO1
- genomics-online: gRNA clones - Search results for available CALCOCO1 gene related products
- Applied Biological Materials CRISPR for CALCOCO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
miRNA for CALCOCO1 Gene
- miRTarBase miRNAs that target CALCOCO1
-
- mmu-mir-466c-5p (MIRT590485)
- mmu-mir-466o-5p (MIRT590486)
- mmu-mir-466b-5p (MIRT590487)
- mmu-mir-466e-5p (MIRT590488)
- mmu-mir-466p-5p (MIRT590489)
- mmu-mir-466a-5p (MIRT590490)
- mmu-mir-1187 (MIRT590491)
- mmu-mir-466l-5p (MIRT590492)
- mmu-mir-466d-5p (MIRT590493)
- mmu-mir-466k (MIRT590494)
- mmu-mir-466i-5p (MIRT590495)
miRNA Products
- Search ViGene Biosciences for CALCOCO1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
- genomics-online: shRNA clones - Search results for available CALCOCO1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CALCOCO1 gene related products
- orf clones - Search results for available CALCOCO1 gene related products
- Applied Biological Materials Clones for CALCOCO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CALCOCO1
-
ViGene Biosciences adenoviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALCOCO1 Gene
Localization for CALCOCO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALCOCO1 Gene
- Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for CALCOCO1 Gene
No Data Available
Interacting Proteins for CALCOCO1 Gene
Selected Interacting proteins:
ENSP00000449960
Q9P1Z2-CACO1_HUMAN
for CALCOCO1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007165 | signal transduction | ISS,IEA | -- |
| GO:0010628 | positive regulation of gene expression | IDA | 16344550 |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CALCOCO1 Gene
Drugs & Compounds for CALCOCO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
Transcripts for CALCOCO1 Gene
mRNA/cDNA for CALCOCO1 Gene
- (9) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (397) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CALCOCO1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CALCOCO1
- genomics-online: gRNA clones - Search results for available CALCOCO1 gene related products
- Applied Biological Materials CRISPR for CALCOCO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
miRNA Products
- Search ViGene Biosciences for CALCOCO1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
- genomics-online: shRNA clones - Search results for available CALCOCO1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CALCOCO1 gene related products
- orf clones - Search results for available CALCOCO1 gene related products
- Applied Biological Materials Clones for CALCOCO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
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| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||||
| SP22: |
Expression for CALCOCO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Platelet (12.0), and Ovary (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CALCOCO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CALCOCO1 Gene:
CALCOCO1SOURCE GeneReport for Unigene cluster for CALCOCO1 Gene:
Hs.156667Evidence on tissue expression from TISSUES for CALCOCO1 Gene
- Nervous system(5)
- Kidney(4.4)
- Spleen(4.3)
- Thyroid gland(4.3)
- Lung(3.1)
- Skin(2.4)
- Intestine(2.3)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CALCOCO1
-
OriGene qPCR primer pairs for CALCOCO1
- genomics-online: primer clones - Search results for available CALCOCO1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCOCO1 Gene
Orthologs for CALCOCO1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CALCOCO1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CALCOCO1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CALCOCO1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Calcoco1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100912282 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CALCOCO1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CALCOCO1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493024 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398195 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | calcoco1a 33 34 |
|
||
| calcoco1b 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.823 34 |
|
OneToMany |
- Species where no ortholog for CALCOCO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CALCOCO1 Gene
(3) SIMAP similar genes for CALCOCO1 Gene using alignment to 11 proteins:
Variants for CALCOCO1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000179222 | -- | 53,723,876(-) | C/T | intron_variant | |
| rs1000555178 | -- | 53,727,380(-) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000754207 | -- | 53,727,172(-) | T/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000823828 | -- | 53,714,558(-) | C/T | intron_variant | |
| rs1000899963 | -- | 53,711,053(-) | T/C | downstream_transcript_variant |
Residual Variation Intolerance Score:
45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.22;
84.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CALCOCO1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CALCOCO1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CALCOCO1 Gene
Disorders for CALCOCO1 Gene
Additional Disease Information for CALCOCO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CALCOCO1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALCOCO1 Gene
Publications for CALCOCO1 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. (PMID: 24245781) Mizuta S … Ito M (Genes to cells : devoted to molecular & cellular mechanisms 2014) 3 4 58
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 44 58
- Genome-wide association study of panic disorder in the Japanese population. (PMID: 19165232) Otowa T … Okazaki Y (Journal of human genetics 2009) 3 44 58
Products for CALCOCO1 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CALCOCO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CALCOCO1
- Search Origene for MassSpec and Protein Over-expression Lysates for CALCOCO1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALCOCO1
- Browse OriGene Inhibitory RNA Products For CALCOCO1
- OriGene qPCR primer pairs and template standards for CALCOCO1
- OriGene qPCR primer pairs for CALCOCO1
- OriGene CRISPR knockouts for CALCOCO1
- OriGene ORF clones in human for CALCOCO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CALCOCO1
- GenScript: Next-day shipping of latest version cDNA ORF clones for CALCOCO1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CALCOCO1
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- GenScript Custom overexpressing Cell Line Services for CALCOCO1
- GenScript: Design CRISPR guide RNA sequences for CALCOCO1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CALCOCO1
- Sino Biological Human cDNA Clone for CALCOCO1
- Browse Sino Biological Cell Lysates
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CALCOCO1
- Novus Biologicals lysates and proteins for CALCOCO1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CALCOCO1
- Abcam proteins for CALCOCO1
- Find your target
- Browse Primary Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CALCOCO1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALCOCO1
- VectorBuilder custom plasmid, inducible vectors for CALCOCO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALCOCO1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available CALCOCO1 Antibodies ranked by validation data
- Compare Top CALCOCO1 Antibodies
- antibodies-online: Search results for available CALCOCO1 related products ranked by validation data
- antibodies-online: Search results for 5 available CALCOCO1 Proteins ranked by validation data
- Compare Top CALCOCO1 Proteins
- GeneTex CALCOCO1 antibody for CALCOCO1
- Search GeneTex for Proteins for CALCOCO1
- ViGene Biosciences adenoviral particle packaged cDNA for CALCOCO1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CALCOCO1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CALCOCO1 gene
- Search ViGene Biosciences for CALCOCO1
- Santa Cruz Biotechnology (SCBT) Antibodies for CALCOCO1
- Search Santa Cruz Biotechnology (SCBT) for CALCOCO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CALCOCO1
- Horizon Cell Lines for CALCOCO1
- genomics-online: cdna clones - Search results for available CALCOCO1 gene related products
- orf clones - Search results for available CALCOCO1 gene related products
- genomics-online: gRNA clones - Search results for available CALCOCO1 gene related products
- genomics-online: primer clones - Search results for available CALCOCO1 gene related products
- genomics-online: shRNA clones - Search results for available CALCOCO1 gene related products
Sources for CALCOCO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew