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CALCOCO1 Gene(Protein Coding)

Calcium Binding And Coiled-Coil Domain 1

GCID:
GC12M053709
GIFtS:
54
Genes Participants
UDN Logo

Aliases for CALCOCO1 Gene

Aliases for CALCOCO1 Gene

  • Calcium Binding And Coiled-Coil Domain 1 2 3 5
  • Coiled-Coil Leucine Zipper Coactivator 1 2 3
  • Inorganic Pyrophosphatase Activator 2 3
  • Coiled-Coil Coactivator Protein 3 4
  • Sarcoma Antigen NY-SAR-3 3 4
  • Calphoglin 3 4
  • KIAA1536 4
  • PP13275 3
  • Cocoa 3

External Ids for CALCOCO1 Gene

Previous GeneCards Identifiers for CALCOCO1 Gene

  • GC12M052392
  • GC12M054105
  • GC12M051142

Summaries for CALCOCO1 Gene

GeneCards Summary for CALCOCO1 Gene

CALCOCO1 (Calcium Binding And Coiled-Coil Domain 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAX1BP1.

UniProtKB/Swiss-Prot for CALCOCO1 Gene

  • Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

  • Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.

Gene Wiki entry for CALCOCO1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCOCO1 Gene

Genomics for CALCOCO1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CALCOCO1 Gene

Enhancers for CALCOCO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CALCOCO1 on UCSC Golden Path with GeneCards custom track

Promoters for CALCOCO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CALCOCO1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CALCOCO1 gene promoter:

Genomic Location for CALCOCO1 Gene

Chromosome:
12
Start:
53,708,517 bp from pter
End:
53,727,745 bp from pter
Size:
19,229 bases
Orientation:
Minus strand

Genomic View for CALCOCO1 Gene

Genes around CALCOCO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCOCO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCOCO1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CALCOCO1 Gene

Proteins for CALCOCO1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CALCOCO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Z2-CACO1_HUMAN
    Recommended name:
    Calcium-binding and coiled-coil domain-containing protein 1
    Protein Accession:
    Q9P1Z2
    Secondary Accessions:
    • B3KVA8
    • Q6FI59
    • Q71RC3
    • Q86WF8
    • Q96JU3
    • Q9H090

    Protein attributes for CALCOCO1 Gene

    Size:
    691 amino acids
    Molecular mass:
    77336 Da
    Quaternary structure:
    • Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref.1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
    SequenceCaution:
    • Sequence=BAA96060.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CALCOCO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCOCO1 Gene

Proteomics data for CALCOCO1 Gene at MOPED

Protein Expression for CALCOCO1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CALCOCO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALCOCO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CoCoA

No data available for DME Specific Peptides for CALCOCO1 Gene

Domains & Families for CALCOCO1 Gene

Protein Domains for CALCOCO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CALCOCO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1Z2

UniProtKB/Swiss-Prot:

CACO1_HUMAN :
  • The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
  • Belongs to the CALCOCO family.
Domain:
  • The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
  • The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).
  • Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.
Family:
  • Belongs to the CALCOCO family.
genes like me logo Genes that share domains with CALCOCO1: view

No data available for Gene Families for CALCOCO1 Gene

Function for CALCOCO1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CALCOCO1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
UniProtKB/Swiss-Prot Function:
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.

Gene Ontology (GO) - Molecular Function for CALCOCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 24245781
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IEA,IPI 16189514
GO:0008013 beta-catenin binding IPI 16344550
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 16344550
genes like me logo Genes that share ontologies with CALCOCO1: view

Phenotypes for CALCOCO1 Gene

GenomeRNAi human phenotypes for CALCOCO1:
genes like me logo Genes that share phenotypes with CALCOCO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCOCO1

CRISPR Products

miRNA for CALCOCO1 Gene

miRTarBase miRNAs that target CALCOCO1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALCOCO1 Gene

Localization for CALCOCO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCOCO1 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCOCO1 Gene COMPARTMENTS Subcellular localization image for CALCOCO1 gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for CALCOCO1 Gene

Pathways & Interactions for CALCOCO1 Gene

SuperPathways for CALCOCO1 Gene

PathCards logoMore details on SuperPathways for CALCOCO1
No Data Available

Gene Ontology (GO) - Biological Process for CALCOCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0030518 intracellular steroid hormone receptor signaling pathway IEA,ISS --
genes like me logo Genes that share ontologies with CALCOCO1: view

No data available for Pathways by source and SIGNOR curated interactions for CALCOCO1 Gene

Drugs & Compounds for CALCOCO1 Gene

Products:

  1. Drug

(1) Drugs for CALCOCO1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CALCOCO1: view

Transcripts for CALCOCO1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CALCOCO1 Gene

(6) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(397) Selected AceView cDNA sequences:
(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCOCO1 Gene

Calcium binding and coiled-coil domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCOCO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - - -
SP16: - - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - -
SP22:

ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
SP1: -
SP2: -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CALCOCO1 Gene

GeneLoc Exon Structure for
CALCOCO1
ECgene alternative splicing isoforms for
CALCOCO1

Expression for CALCOCO1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CALCOCO1 Gene

mRNA expression in normal human tissues for CALCOCO1 Gene
mRNA expression by BioGPS for CALCOCO1 GenemRNA expression by GTEx for CALCOCO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CALCOCO1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Platelet (12.0), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALCOCO1 Gene



SOURCE GeneReport for Unigene cluster for CALCOCO1 Gene Hs.156667

genes like me logo Genes that share expression patterns with CALCOCO1: view

Protein tissue co-expression partners for CALCOCO1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALCOCO1 Gene

Orthologs for CALCOCO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCOCO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CALCOCO1 35
  • 91.11 (n)
  • 92.92 (a)
CALCOCO1 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CALCOCO1 35
  • 88.84 (n)
  • 91.88 (a)
CALCOCO1 36
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Calcoco1 35
  • 87.94 (n)
  • 89.29 (a)
Calcoco1 16
Calcoco1 36
  • 89 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CALCOCO1 35
  • 99.71 (n)
  • 99.71 (a)
CALCOCO1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia LOC100912282 35
  • 87.8 (n)
  • 89.15 (a)
platypus
(Ornithorhynchus anatinus)
 Mammalia CALCOCO1 36
  • 73 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CALCOCO1 36
  • 53 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493024 35
  • 56.63 (n)
  • 49.33 (a)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398195 35
zebrafish
(Danio rerio)
 Actinopterygii -- 35
calcoco1a 35
  • 51.05 (n)
  • 39.32 (a)
calcoco1a 36
  • 33 (a)
 OneToMany
calcoco1b 36
  • 31 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.823 36
  • 21 (a)
 OneToMany
Species with no ortholog for CALCOCO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCOCO1 Gene

ENSEMBL:
Gene Tree for CALCOCO1 (if available)
TreeFam:
Gene Tree for CALCOCO1 (if available)

Paralogs for CALCOCO1 Gene

Paralogs for CALCOCO1 Gene

(3) SIMAP similar genes for CALCOCO1 Gene using alignment to 11 proteins:

genes like me logo Genes that share paralogs with CALCOCO1: view

Variants for CALCOCO1 Gene

Sequence variations from dbSNP and Humsavar for CALCOCO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3741659 - 53,715,875(-) CGGCA(A/G)GCTGG nc-transcript-variant, reference, missense
rs2077285 -- 53,721,139(+) GGCCA(A/C)ATCTG intron-variant
rs7301983 -- 53,719,255(+) gcgca(A/G)tggct intron-variant
rs7302258 -- 53,719,438(+) tgaga(A/G)ttgct intron-variant
rs7310848 -- 53,721,452(+) GGTCA(A/G)TGGAC intron-variant

Variation tolerance for CALCOCO1 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CALCOCO1 Gene

Disorders for CALCOCO1 Gene

Relevant External Links for CALCOCO1

Genetic Association Database (GAD)
CALCOCO1
Human Genome Epidemiology (HuGE) Navigator
CALCOCO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCOCO1

No disorders were found for CALCOCO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALCOCO1 Gene

Publications for CALCOCO1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. (PMID: 15522220) Takahashi K. … Ingi T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  4. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for CALCOCO1 Gene

Sources for CALCOCO1 Gene

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