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Aliases for CALCB Gene

Aliases for CALCB Gene

  • Calcitonin Related Polypeptide Beta 2 3
  • Calcitonin-Related Polypeptide Beta 3 5
  • Calcitonin Gene-Related Peptide II 3 4
  • Beta-Type CGRP 3 4
  • Calcitonin 2 2 3
  • Beta-CGRP 3 4
  • CGRP-II 3 4
  • CALC2 3 4
  • CGRP2 3

External Ids for CALCB Gene

Previous HGNC Symbols for CALCB Gene

  • CALC2

Previous GeneCards Identifiers for CALCB Gene

  • GC11P016107
  • GC11M015674
  • GC11P015135
  • GC11P015059
  • GC11P015051
  • GC11P014883
  • GC11P014778

Summaries for CALCB Gene

GeneCards Summary for CALCB Gene

CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include medullary thyroid carcinoma, familial and ewing sarcoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.

UniProtKB/Swiss-Prot for CALCB Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Tocris Summary for CALCB Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCB Gene

Genomics for CALCB Gene

Regulatory Elements for CALCB Gene

Promoters for CALCB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CALCB on UCSC Golden Path with GeneCards custom track

Genomic Location for CALCB Gene

Chromosome:
11
Start:
14,904,997 bp from pter
End:
15,082,342 bp from pter
Size:
177,346 bases
Orientation:
Plus strand

Genomic View for CALCB Gene

Genes around CALCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCB Gene

Proteins for CALCB Gene

  • Protein details for CALCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10092-CALCB_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 2
    Protein Accession:
    P10092
    Secondary Accessions:
    • A8K573
    • D3DQX4
    • Q569I0
    • Q9UCN9

    Protein attributes for CALCB Gene

    Size:
    127 amino acids
    Molecular mass:
    13706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALCB Gene

Proteomics data for CALCB Gene at MOPED

Post-translational modifications for CALCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALCB Gene

Domains & Families for CALCB Gene

Gene Families for CALCB Gene

Suggested Antigen Peptide Sequences for CALCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10092

UniProtKB/Swiss-Prot:

CALCB_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCB: view

Function for CALCB Gene

Molecular function for CALCB Gene

GENATLAS Biochemistry:
calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
genes like me logo Genes that share phenotypes with CALCB: view

Animal Models for CALCB Gene

MGI Knock Outs for CALCB:

Animal Model Products

miRNA for CALCB Gene

miRTarBase miRNAs that target CALCB

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCB Gene

Localization for CALCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCB Gene COMPARTMENTS Subcellular localization image for CALCB gene
Compartment Confidence
extracellular 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CALCB Gene

Pathways & Interactions for CALCB Gene

genes like me logo Genes that share pathways with CALCB: view

Pathways by source for CALCB Gene

Interacting Proteins for CALCB Gene

Gene Ontology (GO) - Biological Process for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 2985435
genes like me logo Genes that share ontologies with CALCB: view

No data available for SIGNOR curated interactions for CALCB Gene

Drugs & Compounds for CALCB Gene

(1) Drugs for CALCB Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-0974 Investigational Pharma Target 0

(5) Additional Compounds for CALCB Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
PHM 27 (human)
118025-43-7
SUN-B 8155
345893-91-6
genes like me logo Genes that share compounds with CALCB: view

Transcripts for CALCB Gene

mRNA/cDNA for CALCB Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCB Gene

Calcitonin-related polypeptide beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCB Gene

No ASD Table

Relevant External Links for CALCB Gene

GeneLoc Exon Structure for
CALCB
ECgene alternative splicing isoforms for
CALCB

Expression for CALCB Gene

mRNA expression in normal human tissues for CALCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCB Gene

This gene is overexpressed in Brain - Hypothalamus (x24.1).

SOURCE GeneReport for Unigene cluster for CALCB Gene Hs.534305

genes like me logo Genes that share expression patterns with CALCB: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CALCB Gene

Orthologs for CALCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCB 36
  • 91 (a)
OneToOne
CALCB 35
  • 99.48 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia CALCB 35
  • 76.23 (n)
  • 64.75 (a)
CRSP1 36
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CALCA 36
  • 48 (a)
ManyToMany
CALCB 35
  • 76.64 (n)
  • 62.2 (a)
mouse
(Mus musculus)
Mammalia Calca 16
Calcb 36
  • 71 (a)
OneToOne
Calca 35
  • 84.39 (n)
  • 80.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Calca 35
  • 83.6 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves CALCA 36
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487527 35
  • 71.72 (n)
  • 77.27 (a)
zebrafish
(Danio rerio)
Actinopterygii calca 36
  • 36 (a)
OneToMany
Species with no ortholog for CALCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCB Gene

ENSEMBL:
Gene Tree for CALCB (if available)
TreeFam:
Gene Tree for CALCB (if available)

Paralogs for CALCB Gene

Paralogs for CALCB Gene

(2) SIMAP similar genes for CALCB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALCB: view

Variants for CALCB Gene

Sequence variations from dbSNP and Humsavar for CALCB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1042885 -- 15,078,505(+) TTGTG(A/G)ACTTC utr-variant-3-prime
rs1540147 -- 15,073,203(+) GGGAC(A/G)GGTGG upstream-variant-2KB
rs1540148 -- 15,073,584(+) TCCGC(G/T)GGGAA upstream-variant-2KB
rs1945610 -- 15,076,196(+) GTAGC(A/G)TATAG intron-variant
rs1945611 -- 15,079,122(+) CATCA(C/T)GTATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CALCB Gene

Variant ID Type Subtype PubMed ID
nsv897007 CNV Gain 21882294
nsv897008 CNV Loss 21882294

Variation tolerance for CALCB Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCB Gene

HapMap Linkage Disequilibrium report
CALCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCB Gene

Disorders for CALCB Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALCB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
medullary thyroid carcinoma, familial
  • medullary thyroid carcinoma
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search CALCB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCB

Genetic Association Database (GAD)
CALCB
Human Genome Epidemiology (HuGE) Navigator
CALCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCB
genes like me logo Genes that share disorders with CALCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCB Gene

Publications for CALCB Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48 67
  2. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PMID: 15761041) Linscheid P. … MA1ller B. (Endocrinology 2005) 3 23
  3. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PMID: 8468047) Hoovers J.M. … Mannens M. (Genomics 1993) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3

Products for CALCB Gene

Sources for CALCB Gene

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