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Aliases for CALCB Gene

Aliases for CALCB Gene

  • Calcitonin-Related Polypeptide Beta 2 3
  • CALC2 3 4 6
  • Calcitonin Gene-Related Peptide II 3 4
  • Beta-Type CGRP 3 4
  • Calcitonin 2 2 3
  • Beta-CGRP 3 4
  • CGRP-II 3 4
  • Calcitonin Gene-Related Peptide 2 3
  • CGRP2 3

External Ids for CALCB Gene

Previous HGNC Symbols for CALCB Gene

  • CALC2

Previous GeneCards Identifiers for CALCB Gene

  • GC11P016107
  • GC11M015674
  • GC11P015135
  • GC11P015059
  • GC11P015051
  • GC11P014883
  • GC11P014778

Summaries for CALCB Gene

GeneCards Summary for CALCB Gene

CALCB (Calcitonin-Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include ewing sarcoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity. An important paralog of this gene is CALCA.

UniProtKB/Swiss-Prot for CALCB Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role

Tocris Summary for CALCB Gene

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCB Gene

Genomics for CALCB Gene

Regulatory Elements for CALCB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CALCB Gene

Start:
14,904,997 bp from pter
End:
15,082,342 bp from pter
Size:
177,346 bases
Orientation:
Plus strand

Genomic View for CALCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCB Gene

Proteins for CALCB Gene

  • Protein details for CALCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10092-CALCB_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 2
    Protein Accession:
    P10092
    Secondary Accessions:
    • A8K573
    • D3DQX4
    • Q569I0
    • Q9UCN9

    Protein attributes for CALCB Gene

    Size:
    127 amino acids
    Molecular mass:
    13706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALCB Gene

Proteomics data for CALCB Gene at MOPED

Post-translational modifications for CALCB Gene

  • Glycosylation at Ser34, Ser35, Thr40, Ser106, Thr111, and Ser115
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CALCB Gene

Domains for CALCB Gene

Gene Families for CALCB Gene

HGNC:

Suggested Antigen Peptide Sequences for CALCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10092

UniProtKB/Swiss-Prot:

CALCB_HUMAN :
  • P10092
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCB: view

Function for CALCB Gene

Molecular function for CALCB Gene

GENATLAS Biochemistry: calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role

Gene Ontology (GO) - Molecular Function for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity TAS 2985435
genes like me logo Genes that share ontologies with CALCB: view

Animal Model Products

CRISPR Products

miRNA for CALCB Gene

miRTarBase miRNAs that target CALCB

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALCB Gene

Localization for CALCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCB Gene COMPARTMENTS Subcellular localization image for CALCB gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CALCB: view

Pathways for CALCB Gene

genes like me logo Genes that share pathways with CALCB: view

Pathways by source for CALCB Gene

Interacting Proteins for CALCB Gene

Gene Ontology (GO) - Biological Process for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 2985435
GO:0007165 signal transduction TAS 2985435
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with CALCB: view

Compounds for CALCB Gene

(5) Tocris Compounds for CALCB Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]
genes like me logo Genes that share compounds with CALCB: view

Transcripts for CALCB Gene

mRNA/cDNA for CALCB Gene

(13) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCB Gene

Calcitonin-related polypeptide beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCB Gene

No ASD Table

Relevant External Links for CALCB Gene

GeneLoc Exon Structure for
CALCB
ECgene alternative splicing isoforms for
CALCB

Expression for CALCB Gene

mRNA expression in normal human tissues for CALCB Gene

mRNA differential expression in normal tissues according to GTEx for CALCB Gene

This gene is overexpressed in Brain - Hypothalamus (24.1).

SOURCE GeneReport for Unigene cluster for CALCB Gene Hs.534305

genes like me logo Genes that share expressions with CALCB: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CALCB Gene

Orthologs for CALCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCB 35
  • 99.48 (n)
  • 99.21 (a)
CALCB 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALCB 35
  • 76.23 (n)
  • 64.75 (a)
CRSP1 36
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CALCA 36
  • 48 (a)
ManyToMany
CALCB 35
  • 76.64 (n)
  • 62.2 (a)
mouse
(Mus musculus)
Mammalia Calca 35
  • 84.39 (n)
  • 80.95 (a)
Calcb 16
Calcb 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Calca 35
  • 83.6 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves CALCA 36
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487527 35
  • 71.72 (n)
  • 77.27 (a)
zebrafish
(Danio rerio)
Actinopterygii calca 36
  • 36 (a)
OneToMany
Species with no ortholog for CALCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCB Gene

ENSEMBL:
Gene Tree for CALCB (if available)
TreeFam:
Gene Tree for CALCB (if available)

Paralogs for CALCB Gene

Paralogs for CALCB Gene

Selected SIMAP similar genes for CALCB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALCB: view

Variants for CALCB Gene

Sequence variations from dbSNP and Humsavar for CALCB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3928 -- 15,078,350(+) ATCCT(C/G)TTGAT utr-variant-3-prime, intron-variant
rs1042885 -- 15,078,505(+) TTGTG(A/G)ACTTC utr-variant-3-prime, intron-variant
rs1540139 -- 15,074,873(+) TGCCT(C/T)TGAAG intron-variant
rs1540140 -- 15,078,660(+) ATTTT(A/G)AAACA downstream-variant-500B, intron-variant
rs1540145 -- 15,073,200(+) GGGGG(A/G/T)ACAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CALCB Gene

Variant ID Type Subtype PubMed ID
nsv897007 CNV Gain 21882294
nsv897008 CNV Loss 21882294

Relevant External Links for CALCB Gene

HapMap Linkage Disequilibrium report
CALCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCB Gene

Disorders for CALCB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CALCB Gene including...

Search for CALCB Gene in MalaCards »

(1) University of Copenhagen DISEASES for CALCB Gene

(1) Novoseek inferred disease relationships for CALCB Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma medullary 58.8 1

Relevant External Links for CALCB

Genetic Association Database (GAD)
CALCB
Human Genome Epidemiology (HuGE) Navigator
CALCB
genes like me logo Genes that share disorders with CALCB: view

No data available for UniProtKB/Swiss-Prot for CALCB Gene

Publications for CALCB Gene

  1. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PMID: 8468047) Hoovers J.M. … Mannens M. (Genomics 1993) 3 23
  2. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PMID: 15761041) Linscheid P. … MA1ller B. (Endocrinology 2005) 3 23
  3. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PMID: 1318039) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1992) 3 4
  4. Isolation, purification and characterization of beta-hCGRP from human spinal cord. (PMID: 2322288) Wimalawansa S.J. … McIntyre I. (Biochem. Biophys. Res. Commun. 1990) 3 4
  5. A second human calcitonin/CGRP gene. (PMID: 2985435) Steenbergh P.H. … Jansz H.S. (FEBS Lett. 1985) 3 4

Products for CALCB Gene

  • antibodies-online peptides for CALCB
  • antibodies-online antibodies for CALCB
  • antibodies-online kits for CALCB

Sources for CALCB Gene

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