Aliases for CALCB Gene
External Ids for CALCB Gene
Previous HGNC Symbols for CALCB Gene
Previous GeneCards Identifiers for CALCB Gene
GeneCards Summary for CALCB Gene
CALCB (Calcitonin-Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include medullary thyroid carcinoma, familial. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.
UniProtKB/Swiss-Prot for CALCB Gene
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.