Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALCB Gene

protein-coding   GIFtS: 54
GCID: GC11P014926

Calcitonin-Related Polypeptide Beta

(Previous name: calcitonin 2)
(Previous symbol: CALC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcitonin-Related Polypeptide Beta1 2     CGRP-II2 3
CALC21 2 3 5     CGRP22
Calcitonin 21 2     beta-CGRP2
Beta-Type CGRP2 3     Calcitonin Gene-Related Peptide 22
Calcitonin Gene-Related Peptide II2 3     Beta-CGRP3

External Ids:    HGNC: 14381   Entrez Gene: 7972   Ensembl: ENSG000001758687   OMIM: 1141605   UniProtKB: P100923   

Export aliases for CALCB gene to outside databases

Previous GC identifers: GC11P016107 GC11M015674 GC11P015135 GC11P015059 GC11P015051 GC11P014883 GC11P014778


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CALCB Gene: 
CALCB (calcitonin-related polypeptide beta) is a protein-coding gene. Diseases associated with CALCB include thyroid medullary carcinoma, and congestive heart failure, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include neuropeptide hormone activity. An important paralog of this gene is CALCA.

UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092
Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic
vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALCB gene promoter:
         Bach1   STAT1   GATA-3   AP-4   IRF-1   GATA-1   GATA-2   AREB6   RORalpha1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCB promoter sequence
   Search SABiosciences Chromatin IP Primers for CALCB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2-p15.1   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p14.2-p12

CALCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P014926:  view genomic region     (about GC identifiers)

Start:
14,926,543 bp from pter      End:
15,103,888 bp from pter
Size:
177,346 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092 (See protein sequence)
Recommended Name: Calcitonin gene-related peptide 2 precursor  
Size: 127 amino acids; 13706 Da
Subcellular location: Secreted
Secondary accessions: A8K573 D3DQX4 Q569I0 Q9UCN9

Explore the universe of human proteins at neXtProt for CALCB: NX_P10092

Explore proteomics data for CALCB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10092

  • CALCB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALCB Protein Expression
    REFSEQ proteins: NP_000719.1  
    ENSEMBL proteins: 
     ENSP00000428882   ENSP00000346017   ENSP00000433490  
    Reactome Protein details: P10092
    Human Recombinant Protein Products for CALCB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALCB
    OriGene Protein Over-expression Lysate for CALCB
    OriGene MassSpec for CALCB 
    OriGene Custom Protein Services for CALCB
    GenScript Custom Purified and Recombinant Proteins Services for CALCB
    Sino Biological Recombinant Protein for CALCB
    Sino Biological Cell Lysate for CALCB 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    CALCB for ontologies           About GeneDecksing



    CALCB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALCB
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CALCB
    GenScript Custom Superior Antibodies Services for CALCB
    Novus Biologicals CALCB Antibody
    Search for Antibodies for CALCB at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CALCB
    LSBio Antibodies in human, mouse, rat for CALCB 

    Assay Products for CALCB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALCB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR018360 Calcitonin_CS
     IPR015476 Procalcitonin_gene-rel_peptide
     IPR001693 Calcitonin_peptide-like
     IPR021116 Procalcitonin/adrenomedullin
     IPR021117 Procalcitonin-like

    Graphical View of Domain Structure for InterPro Entry P10092

    ProtoNet protein and cluster: P10092

    2 Blocks protein domains:
    IPB000443 Islet amyloid protein (amylin) signature
    IPB002163 Beta-type calcitonin signature


    UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092
    Similarity: Belongs to the calcitonin family


    CALCB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALCB_HUMAN, P10092
    Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic
    vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role

         Genatlas biochemistry entry for CALCB:
    calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and
    hypotensor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
    GO:0005184neuropeptide hormone activity TAS2985435
         
    CALCB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALCB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALCB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCB
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCB:
    hsa-miR-3163 hsa-miR-4254 hsa-miR-16-2* hsa-miR-124 hsa-miR-513b hsa-miR-96* hsa-miR-506 hsa-miR-195*
    SwitchGear 3'UTR luciferase reporter plasmidCALCB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALCB
    Sirion Biotech Customized adenovirus for overexpression of CALCB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALCB (see all 6)
    OriGene ORF clones in mouse, rat for CALCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALCB (NM_000728)
    Sino Biological Human cDNA Clone for CALCB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB
    Sirion Biotech Customized lentivirus for stable overexpression of CALCB 
                         Customized lentivirus expression plasmids for stable overexpression of CALCB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALCB
    Search LifeMap BioReagents cell lines for CALCB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALCB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    Class B/2 (Secretin family receptors)0.36
    G alpha (s) signalling events0.31
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    4Calcitonin-like ligand receptors
    Calcitonin-like ligand receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for CALCB (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    Calcitonin-like ligand receptors
    GPCR ligand binding



    CALCB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for CALCB (ENSP000003460174) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADMENSP000002781754STRING: ENSP00000278175
    ADM2ENSP000003790864STRING: ENSP00000379086
    CALCAENSP000003317464STRING: ENSP00000331746
    CALCRENSP000003525614STRING: ENSP00000352561
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS2985435
    GO:0007165signal transduction TAS2985435
    GO:0042311vasodilation IEA--

    CALCB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CALCB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    Search CenterWatch for drugs/clinical trials and news about CALCB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALCB gene: 
    NM_000728.3  

    Unigene Cluster for CALCB:

    Calcitonin-related polypeptide beta
    Hs.534305  [show with all ESTs]
    Unigene Representative Sequence: AK127720
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523376 ENST00000324229(uc001mlx.1) ENST00000533448(uc009ygr.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCB
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCB:
    hsa-miR-3163 hsa-miR-4254 hsa-miR-16-2* hsa-miR-124 hsa-miR-513b hsa-miR-96* hsa-miR-506 hsa-miR-195*
    SwitchGear 3'UTR luciferase reporter plasmidCALCB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCB
    Clone
    Products:
         
    OriGene clones in human, mouse for CALCB (see all 6)
    OriGene ORF clones in mouse, rat for CALCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALCB (NM_000728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB
    Sirion Biotech Customized lentivirus for stable overexpression of CALCB 
                         Customized lentivirus expression plasmids for stable overexpression of CALCB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALCB
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALCB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCB

    Additional mRNA sequence: 

    AK054728.1 AK127720.1 AK291188.1 BC092468.1 X02404.1 

    4 DOTS entries:

    DT.303806  DT.95268778  DT.101965533  DT.120741980 

    13 AceView cDNA sequences:

    AK054728 NM_000728 BM920106 BI668461 BC008428 BX094021 AI937230 M28641 
    BV193074 AH002652 X02404 M28640 BF698037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALCB expression in normal human tissues (normalized intensities)      CALCB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTATAAT
    CALCB Expression
    About this image


    CALCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Root Ganglion   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/bladder   
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See CALCB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALCB

    SOURCE GeneReport for Unigene cluster: Hs.534305
        SABiosciences Custom PCR Arrays for CALCB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALCB
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALCB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CALCB gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcb5 calcitonin-related polypeptide, beta   --   7 (60.19 cM) 114718643 
    chicken
    (Gallus gallus)
    Aves CALCA6
    Calcitonin
    28(a)
    possible ortholog
    5(9980460-9984994)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    possible ortholog
    1(64833205-64838856)
    zebrafish
    (Danio rerio)
    Actinopterygii calca1 calcitonin/calcitonin-related polypeptide, alpha 62.71(n)
    61.02(a)
      436744  NM_001002471.1  NP_001002471.1 


    ENSEMBL Gene Tree for CALCB (if available)
    TreeFam Gene Tree for CALCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALCB gene
    CALCA2  
    2 SIMAP similar genes for CALCB using alignment to 2 protein entries:     CALCB_HUMAN (see all proteins):
    CALCA    IAPP

    CALCB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in CALCB are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143736951,2
    F--15093304(+) CCGGGC/TGGCAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1828419031,2
    --15093404(+) CAGCTC/GGGTCC 1 -- us2k10--------
    rs1509060581,2
    --15093426(+) AAGGAC/TCCAGA 1 -- us2k10--------
    rs79451661,2
    C,F,A,H--15093487(+) AGCATT/CACCTG 1 -- us2k115Minor allele frequency- C:0.24NS EA NA WA CSA 792
    rs1476898681,2
    C--15093500(+) GGGTT-/CCCGCC 1 -- us2k10--------
    rs1384639251,2
    --15093579(+) TGGGCA/GCCGGC 1 -- us2k10--------
    rs79452901,2
    C,F,A,H--15093581(+) GGCGCT/CGGCGG 1 -- us2k19Minor allele frequency- C:0.23NA CSA WA EA 369
    rs2002413171,2
    --15093733(+) ATCTT-/CTCCTGGA 1 -- us2k10--------
    rs1415486841,2
    --15093740(+) CCTGGA/GACCCG 1 -- us2k10--------
    rs1461784931,2
    C--15093842(+) GTGTCA/GGTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALCB (14926543 - 15103888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CALCB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897008CNV Loss21882294
    nsv897007CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCB
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114160    OMIM disorders: --

    6 diseases for CALCB:    About MalaCards
    thyroid medullary carcinoma    congestive heart failure    pheochromocytoma    thyroiditis
    cerebritis    sarcoma

    1 disease from the University of Copenhagen DISEASES database for CALCB:
    Thyroid medullary carcinoma

    CALCB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CALCB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 58.8 1 8386116 (1)

    Genetic Association Database (GAD): CALCB
    Human Genome Epidemiology (HuGE) Navigator: CALCB (1 document)

    Export disorders for CALCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALCB gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with CALCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)1, 2 Kitamura K.... Eto T. (1992)
    5. Isolation, purification and characterization of beta-hCGRP from human spinal cord. (PubMed id 2322288)1, 2 Wimalawansa S.J....McIntyre I. (1990)
    6. Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. (PubMed id 3492492)1, 2 Petermann J.B.... Fischer J.A. (1987)
    7. Structure and expression of the human calcitonin/CGRP genes. (PubMed id 3492393)1, 2 Steenbergh P.H.... Jansz H.S. (1986)
    8. A second human calcitonin/CGRP gene. (PubMed id 2985435)1, 2 Steenbergh P.H....Jansz H.S. (1985)
    9. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PubMed id 15761041)1, 9 Linscheid P....Muller B. (2005)
    10. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PubMed id 8468047)1, 9 Hoovers J.M....Mannens M. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 797 HGNC: 1438 AceView: CALCBandCALCP Ensembl:ENSG00000175868 euGenes: HUgn797
    ECgene: CALCB H-InvDB: CALCB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALCB gene:
    Search GeneIP for patents involving CALCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CALCB
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CALCB  
     OriGene qPCR primer pairs and template standards for CALCB   OriGene Protein Over-expression Lysate for CALCB  
     OriGene MassSpec something-or-other for CALCB   OriGene clones in human, mouse for CALCB  
     OriGene qSTAR qPCR primer pairs in human, mouse for CALCB   OriGene Purified Protein for CALCB  
     OriGene ORF clones in mouse, rat for CALCB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CALCB   OriGene Custom Protein Services for CALCB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALCB
     QIAGEN SeqTarget long-range PCR primers for resequencing CALCB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCB
     GenScript Custom Purified and Recombinant Proteins Services for CALCB GenScript cDNA clones with any tag delivered in your preferred vector for CALCB
     GenScript Custom Assay Services for CALCB GenScript Custom Superior Antibodies Services for CALCB
     GenScript Custom overexpressing Cell Line Services for CALCB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CALCB promoter
     Search Chromatin IP Primers for CALCB
     RT2 qPCR Primer Assay in human, mouse, rat CALCB
     Search GNC Networks for CALCB
     SABiosciences Custom PCR Arrays for CALCB
     Tocris compounds for CALCB
     Proteins and Antibodies for CALCB
     Cell Lysates for CALCB
     cDNA Clones for CALCB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CALCB antibodies
     Search for Antibodies for CALCB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CALCB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CALCB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB
     SwitchGear 3'UTR luciferase reporter plasmids for CALCB
     SwitchGear Promoter luciferase reporter plasmids for CALCB
     Search ThermoFisher Antibodies for CALCB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CALCB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALCB
    Customized:
     lentivirus for stable overexpression of CALCB
     lentivirus expression plasmids for stable overexpression of CALCB
     adenovirus for overexpression of CALCB
     LSBio Antibodies in human, mouse, rat for CALCB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CALCB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4