CALCB Gene
protein-coding GIFtS: 52
GCID: GC11P014926
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|
calcitonin-related polypeptide beta(Previous name: calcitonin 2 )
(Previous symbol: CALC2)
| |
Aliases
for CALCB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcitonin-Related Polypeptide Beta1 2 | | FLJ301661 | | CALC21 2 3 5 | | CGRP22 | | CGRP-II1 2 3 | | Beta-CGRP3 | | Calcitonin 21 2 | | Calcitonin Gene-Related Peptide 22 | | Beta-Type CGRP2 3 | | Beta-CGRP3 | | Calcitonin Gene-Related Peptide II2 3 | | |
Export aliases for CALCB gene to outside databasesPrevious GC identifers: GC11P016107 GC11M015674 GC11P015135 GC11P015059 GC11P015051 GC11P014883 GC11P014778 |
Summaries
for CALCB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemicvasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role
|
Genomic Views
for CALCB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CALCB gene promoter:
Bach1 STAT1 GATA-3 AP-4 IRF-1 GATA-1 GATA-2 AREB6 RORalpha1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for CALCB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.2-p15.1 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p14.2-p12CALCB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P014926: view genomic region
(about GC identifiers)
Start:
|
14,926,543 bp from pter |
End:
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15,103,888 bp from pter |
Size:
|
177,346 bases |
Orientation:
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plus strand |
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Proteins
for CALCB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092 (See
protein sequence)Recommended Name: Calcitonin gene-related peptide 2 precursor Size: 127 amino acids; 13706 Da
Subcellular location: Secreted
Secondary accessions: A8K573 D3DQX4 Q569I0 Q9UCN9Explore the universe of human proteins at neXtProt for CALCB: NX_P10092
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10092
CALCB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000719.1
ENSEMBL proteins: ENSP00000428882 ENSP00000346017 ENSP00000433490 Reactome Protein details: P10092
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005625 | soluble fraction |
-- | -- |
CALCB for ontologies About GeneDecksing
CALCB Antibody Products:
Assay Products for CALCB: |
Protein
Domains /
Families
for CALCB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CALCB for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P10092ProtoNet protein and cluster: P10092 2 Blocks protein families: IPB000443 Islet amyloid protein (amylin) signature IPB002163 Beta-type calcitonin signature
UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092Similarity: Belongs to the calcitonin family |
Function
for CALCB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CALCB_HUMAN, P10092Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemicvasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role Genatlas biochemistry entry for CALCB:calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator andhypotensor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CALCB (NM_000728) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALCB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CALCB for ontologies About GeneDecksing
|
Pathways & Interactions
for CALCB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | G beta:gamma signalling through PLC beta | | | 3 | Calcitonin-like ligand receptors | | | 4 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for CALCB (see all 7)
CALCB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALCB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/66 Interacting proteins for CALCB (ENSP000003460174) via UniProtKB, MINT, STRING, and/or I2D (see all 66)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CALCB for ontologies About GeneDecksing
|
Drugs & Compounds
for CALCB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for CALCB available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about CALCB
|
Transcripts
for CALCB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CALCB gene: NM_000728.3 Unigene Cluster for CALCB: Calcitonin-related polypeptide beta Hs.534305 [show with all ESTs]Unigene Representative Sequence: AK1277203 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523376 ENST00000324229(uc001mlx.1) ENST00000533448(uc009ygr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CALCB (NM_000728) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALCB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB |
Additional cDNA sequence: AK054728.1 AK127720.1 AK291188.1 BC092468.1 X02404.1 4 DOTS entries: DT.303806 DT.95268778 DT.101965533 DT.120741980 13 AceView cDNA sequences: NM_000728 BM920106 AK054728 AI937230 BI668461 BC008428 M28641 BX094021 X02404 BV193074 AH002652 M28640 BF698037
GeneLoc Exon Structure
|
Expression
for CALCB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CALCB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGTATAAT
About this image
See CALCB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALCB
SOURCE GeneReport for Unigene cluster: Hs.534305
SABiosciences Custom PCR Arrays for CALCB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB |
Orthologs
for CALCB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CALCB gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
B0FYW9_CHICK6 |
CalcitoninUncharacterized protein |
35(a) |
possible ortholog |
5(11507155-11519384) |
lizard
(Anolis carolinensis) |
Reptilia |
CALCA6 |
-- |
34(a) |
possible ortholog |
1(64836136-64841272) |
zebrafish
(Danio rerio) |
Actinopterygii |
calca1 |
calcitonin/calcitonin-related polypeptide, alpha |
62.71(n)
61.02(a) |
|
436744 NM_001002471.1 NP_001002471.1 |
ENSEMBL Gene Tree for CALCB (if available)
TreeFam Gene Tree for CALCB (if available) |
Paralogs
for CALCB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CALCB gene
- CALCA2
2 SIMAP similar genes for CALCB using alignment to 2 protein entries: CALCB_HUMAN (see all proteins):CALCA IAPP
CALCB for paralogs About GeneDecksing
|
Genomic Variants
for CALCB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CALCB (14926543 - 15103888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALCB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALCB |
|
Disorders
/ Diseases
for CALCB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CALCB for disorders About GeneDecksing
OMIM gene information: 114160
OMIM disorders: --
9  diseases for CALCB: About MalaCardscongestive heart failure thyroid medullary carcinoma thyroid carcinoma thyroiditis
pheochromocytoma carcinoma lung carcinoma sarcoma
cerebritis
1 disease from the University of Copenhagen DISEASES database for CALCB:Thyroid medullary carcinoma 1 Novoseek disease relationship for CALCB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thyroid carcinoma medullary |
58.8 |
1 |
8386116 (1) |
Human Genome Epidemiology (HuGE) Navigator: CALCB (1 document)
Export disorders for CALCB gene to outside databases
|
Publications
for CALCB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CALCB gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with CALCB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)1, 2 Kitamura K.... Eto T. (1992)
- Isolation, purification and characterization of beta-hCGRP from human spinal cord. (PubMed id 2322288)1, 2 Wimalawansa S.J....McIntyre I. (1990)
- Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. (PubMed id 3492492)1, 2 Petermann J.B.... Fischer J.A. (1987)
- Structure and expression of the human calcitonin/CGRP genes. (PubMed id 3492393)1, 2 Steenbergh P.H.... Jansz H.S. (1986)
- A second human calcitonin/CGRP gene. (PubMed id 2985435)1, 2 Steenbergh P.H....Jansz H.S. (1985)
- Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PubMed id 15761041)1, 9 Linscheid P....Muller B. (2005)
- High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PubMed id 8468047)1, 9 Hoovers J.M....Mannens M. (1993)
- Keratinocyte expression of calcitonin gene-related pep tide b: implications for neuropathic and inflammatory pain mechanisms. (PubMed id 21641113)1 Hou Q....Albrecht P. (2011)
|
External Searches for CALCB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CALCB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CALCB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CALCB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CALCB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CALCB gene:
Search GeneIP for patents involving CALCB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CALCB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CALCB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCB | | | OriGene Protein Over-expression Lysate for CALCB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CALCB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CALCB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CALCB | | OriGene Custom Protein Services for CALCB | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALCB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALCB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCB |
| |
 |  |  |  | |
| | | | Tocris compounds for CALCB |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCB |
|  |  |  | | | | Search ThermoFisher Antibodies for CALCB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCB |
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