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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALCA Gene

protein-coding GIFtS: 67
GCID: GC11M014945

calcitonin-related polypeptide alpha

(Previous name: calcitonin 1 )
(Previous symbol: CALC1)

Explore 327 diseases affiliated with
CALCA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcitonin-Related Polypeptide Alpha¹ ²		CGRP1²
CALC1¹ ² ³ ⁵		CT²
Calcitonin 1¹ ²		KC²
Alpha-Type CGRP² ³		Calcitonin¹
Calcitonin Gene-Related Peptide I² ³		Calcitonin/Calcitonin-Related Polypeptide, Alpha²
CGRP-I² ³		Katacalcin¹
CGRP²

External Ids:	HGNC: 1437¹	Entrez Gene: 796²	Ensembl: ENSG00000110680⁷	OMIM: 114130⁵	UniProtKB: P06881³
	UniProtKB: P01258³

Export aliases for CALCA gene to outside databases

Previous GC identifers: GC11M016170 GC11M015736 GC11M015027 GC11M014952 GC11M014671

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALCA:

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific

alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved

in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a

vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms

have been found for this gene.(provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting

the incorporation of those ions in the bones

Function: Katacalcin is a potent plasma calcium-lowering peptide

Gene Wiki entry for CALCA (Calcitonin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALCA gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCA promoter sequence

Search SABiosciences Chromatin IP Primers for CALCA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15.2

CALCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCA gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M014945: view genomic region (about GC identifiers)

Start:	14,988,214 bp from pter	End:	14,993,900 bp from pter
Size:	5,687 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881 (See protein sequence)

Recommended Name: Calcitonin gene-related peptide 1 precursor

Size: 128 amino acids; 13898 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for CALCA:

1LS7 (3D)

Secondary accessions: Q93048 Q9UCP0

Alternative splicing: 3 isoforms: P06881-1 P01258-1 P01258-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258 (See protein sequence)

Recommended Name: Calcitonin precursor

Size: 141 amino acids; 15466 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for CALCA:

2JXZ (3D)

Secondary accessions: B7ZL39 Q13935 Q13937 Q52LX7

Alternative splicing: 3 isoforms: P01258-1 P01258-2 P06881-1 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CALCA: NX_P01258

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01258

CALCA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001029124.1 NP_001029125.1 NP_001732.1

ENSEMBL proteins:

ENSP00000417833 ENSP00000420618 ENSP00000331746 ENSP00000379657 ENSP00000354286

ENSP00000352663

Reactome Protein details: P06881 P01258
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CALCA OriGene Protein Over-expression Lysate (see all 3): CALCA OriGene Custom Protein Services for CALCA
	GenScript Custom Purified and Recombinant Proteins Services for CALCA
	Novus Biologicals CALCA Proteins Novus Biologicals CALCA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CALCA
	Uscn Proteins for CALCA

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	18057382
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

CALCA for ontologies About GeneDecksing

CALCA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CALCA
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	OriGene Antibodies (see all 2): CALCA OriGene Custom Antibody Services for CALCA
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	Novus Biologicals CALCA Antibodies
	Abcam antibodies for CALCA
	Uscn Antibodies for CALCA
	ThermoFisher Antibodies for CALCA

Assay Products for CALCA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALCA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALCA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALCA for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR021118 Procalcitonin_A-typ

IPR018360 Calcitonin_CS

IPR015476 Procalcitonin_gene-rel_peptide

IPR001693 Calcitonin_peptide-like

IPR021116 Procalcitonin/adrenomedullin

Graphical View of Domain Structure for InterPro Entry P06881

Graphical View of Domain Structure for InterPro Entry P01258

ProtoNet protein and cluster: P06881

2 Blocks protein families:

IPB000443 Islet amyloid protein (amylin) signature

IPB002163 Beta-type calcitonin signature

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881

Similarity: Belongs to the calcitonin family

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Similarity: Belongs to the calcitonin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881

Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic

vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates

platelet cAMP

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting

the incorporation of those ions in the bones

Function: Katacalcin is a potent plasma calcium-lowering peptide

Genatlas biochemistry entry for CALCA:

calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed

in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on

chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and

hypotensor

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCA
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCA:
		hsa-miR-374b* hsa-miR-3657
		SwitchGear 3'UTR luciferase reporter plasmid: CALCA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCA (see all 7) OriGene shRNA RFP: CALCA OriGene siRNA: CALCA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CALCA

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		GenScript: all cDNA clones in your preferred vector (see all 3): CALCA (NM_001033953)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALCA
		Search LifeMap BioReagents cell lines for CALCA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IDA	16014619
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IPI	9620797
GO:0031716	calcitonin receptor binding	IPI	8940110
GO:0032403	protein complex binding	IDA	14722252

CALCA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CALCA:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for CALCA: Calca^tm1Hku Calca^tm1Rfg
13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Calca):

behavior/neurological	cardiovascular system	embryogenesis	hearing/vestibular/ear	homeostasis/metabolism
integument	mortality/aging	nervous system	normal	renal/urinary system
respiratory system	skeleton	tumorigenesis

CALCA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Amyloid precursor proteins form ordered fibrils

Amyloid precursor proteins form ordered fibrils

1.00

Amyloids

0.43

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CALCA

	Adenylate cyclase-activating neuropeptides
	Transcription Role of VDR in regulation of genes involved in osteoporosis

1 GeneGo (Thomson Reuters) Pathway for CALCA

Transcription Role of VDR in regulation of genes involved in osteoporosis

2 BioSystems Pathways for CALCA

	Myometrial Relaxation and Contraction Pathways
	Endothelin

5/10 Reactome Pathways for CALCA (see all 10)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Disease
	Amyloids

CALCA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CALCA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/96 Interacting proteins for CALCA (P01258^{1, 2, 3} ENSP00000331746⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP2B2	Q01814², ENSP00000324172⁴	MINT-5204027 MINT-5203983 STRING: ENSP00000324172
ATP2B4	P23634², ENSP00000350310⁴	MINT-5204003 MINT-5203983 STRING: ENSP00000350310
CALCA	P01258²	MINT-8409770 MINT-8409885 MINT-8409840
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001935	endothelial cell proliferation	IDA	17267696
GO:0001944	vasculature development	IDA	17267696
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	IDA	10642343
GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure	IEA	--
GO:0002027	regulation of heart rate	IEA	--

CALCA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CALCA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CALCA available from Tocris Bioscience About this table

Compound	Action	CAS #
CGRP 8-37 (human)	CGRP1 receptor antagonist	[119911-68-1]
CGRP 8-37 (rat)	CGRP1 receptor antagonist	[129121-73-9]
PHM 27 (human)	Potent calcitonin receptor agonist; endogenous analog of human VIP	[118025-43-7]
CGRP (rat)	Potent vasodilator	[96827-03-1]
SUN-B 8155	Non-peptide calcitonin (CT) receptor agonist	[345893-91-6]

2 HMDB Compounds for CALCA About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/130 Novoseek chemical compound relationships for CALCA gene (see all 130) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	89.1	46	10711339 (4), 11755165 (2), 10988349 (2), 11804624 (2) (see all 25)
alendronate	83.8	171	15032563 (10), 11695068 (6), 16523336 (6), 15607319 (6) (see all 99)
vitamin d	83.1	261	15846740 (4), 10446876 (3), 12162505 (3), 2038639 (2) (see all 99)
etidronate	83	112	9205627 (8), 15465502 (4), 8538482 (4), 8608360 (4) (see all 71)
raloxifene	80.9	121	12708951 (3), 10943237 (3), 17376323 (3), 14557222 (3) (see all 99)
risedronate	80.6	73	15032563 (11), 8592950 (5), 17227729 (2), 13680313 (2) (see all 49)
calcium	80.6	1188	16014619 (9), 11695068 (6), 9440370 (6), 10707893 (6) (see all 99)
calogen	80.2	14	9008693 (1), 15167766 (1), 9221486 (1), 2020925 (1) (see all 11)
teriparatide	79.6	50	16709314 (7), 16421647 (5), 18413693 (3), 15167766 (1) (see all 33)
elcatonin	76.9	42	10220278 (5), 7669941 (3), 8181470 (2), 17707708 (2) (see all 14)

Search CenterWatch for drugs/clinical trials and news about CALCA / CALC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALCA gene (3 alternative transcripts):

NM_001033952.2 NM_001033953.2 NM_001741.2

Unigene Cluster for CALCA:

Calcitonin-related polypeptide alpha

Hs.37058 [show with all ESTs]

Unigene Representative Sequence: X02330

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000486207 ENST00000494746(uc001mlv.1 uc001mlw.1) ENST00000469608

ENST00000331587 ENST00000396372 ENST00000361010(uc001mlt.2 uc001mlu.2)

ENST00000359642

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCA
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCA:
		hsa-miR-374b* hsa-miR-3657
		SwitchGear 3'UTR luciferase reporter plasmid: CALCA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCA

Additional cDNA sequence:

BC069684.1 BC069704.1 BC069760.1 BC069778.1 BC093753.1 BC101599.1 BC143562.1 K03512.1

K03513.1 M26095.1 M64486.1 X00356.1 X02330.1 X03662.1

4 DOTS entries:

DT.86840457 DT.100016988 DT.111153 DT.102824295

24/43 AceView cDNA sequences (see all 43):

BX094781 AW296074 BF447272 M64486 NM_001741 BF942171 BC069760 X02330

X03662 X00356 BC069684 AI695720 M26095 BC069704 CD612756 BC069778

CD612754 CB048118 CD612752 AA716058 K03512 BF942434 BF942146 BF942168

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CALCA About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b
SP1:					-
SP2:

ECgene alternative splicing isoforms for CALCA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALCA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAATGCTGT

About this image

CALCA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

Posterior foregut-like cells (A scalable, suspensi...)

See CALCA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALCA

SOURCE GeneReport for Unigene cluster: Hs.37058

SABiosciences Expression via Pathway-Focused PCR Arrays including CALCA:

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

Obesity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CALCA gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Calca^{1 , 5}	calcitonin/calcitonin-related polypeptide, alpha^{1, 5}	84.73(n)¹ 79.39(a)¹		7 (59.99 cM)⁵ 12310¹ NM_007587.2¹ NP_031613.2¹ 114631480⁵
chicken (Gallus gallus)	Aves	CALCA¹	calcitonin-related polypeptide alpha	65.3(n) 53.28(a)		396256 XM_420997.2 XP_420997.1
lizard (Anolis carolinensis)	Reptilia	CALCA⁶	--	45(a)	possible ortholog	1(64836136-64841272)
zebrafish (Danio rerio)	Actinopterygii	calca⁶	calcitonin/calcitonin-related polypeptide, alpha	37(a)	1 → many	7(28806424-28811889)

ENSEMBL Gene Tree for CALCA (if available)
TreeFam Gene Tree for CALCA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CALCA gene

CALCB²

2 SIMAP similar genes for CALCA using alignment to 2 protein entries: CALCA_HUMAN (see all proteins):

CALCB IAPP

CALCA for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CALCA
PGOHUM00000242602

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73420590^1,2	C,	--	14671539(+)	`GTGCAT/AGAAGA`	1	--	ds500¹		1	WA	2
rs11826691^1,2	C,H	--	14671587(+)	`CAAACC/TTGCAT`	1	--	ds500¹		2	NA	67
rs112818874^1,2	C,	--	14671877(+)	`ATACAT/-TTTTA`	1	--	ut3¹		1	CSA	2
rs13306223^1,2	H	--	14672040(+)	`GCTGAC/TGGGGC`	1	--	ut3¹ ese³		4	NS EA	420
rs5243^1,2	C,F,H,	--	14672355(-)	`GTGAGG/ATAATA`	1	--	int¹		26	MN NS EA NA WA CSA	2534
rs35096144^1,2	C,	--	14672463(-)	`CTATAT/CGACCA`	1	--	int¹		5	NS	188
rs112450724^1,2	F	--	14673065(+)	`GAAAGAA/-GAGAA`	1	--	int¹		1	CSA	4
rs34200140^1,2	C,F,	--	14673489(-)	`ACTCCG/ACTCCT`	3	--	int¹ ds500¹		6	NS WA	192
rs34901084^1,2	C,F,H,	--	14673548(-)	`AGCAGG/CAAGAA`	3	--	ds500¹ int¹		20	NS EA NA WA CSA	1910
rs2644688^1,2	C,H	--	14673955(+)	`GATGCA/TAGAAG`	3	--	int¹ ut3¹ ese³ trp³		4	NS EA	420

HapMap Linkage Disequilibrium report for CALCA (14988214 - 14993900 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALCA: --
Human Gene Mutation Database (HGMD): CALCA

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALCA

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CALCA for disorders           About GeneDecksing

OMIM gene information: 114130    OMIM disorders: --

20/327 diseases for CALCA (see all 327):    About MalaCards

spinal cord injury spinal stenosis reflex sympathetic dystrophy complex regional pain syndrome

giant cell reparative granuloma multiple endocrine neoplasia type 2a prurigo nodularis multiple endocrine neoplasia

cluster headache hemiplegic migraine multinodular goiter paroxysmal hemicrania

islet cell tumor osteitis fibrosa cerebrotendinous xanthomatosis osteopenia/osteoporosis

paget disease, juvenile williams-beuren syndrome familial hemiplegic migraine oncogenic osteomalacia

20/28 diseases from the University of Copenhagen DISEASES database for CALCA (see all 28):

Thyroid cancer Osteoporosis Migraine Hypercalcemia

Mammary Paget's disease Paget's disease of bone Hyperparathyroidism Carcinoma

Complex regional pain syndrome Goiter Hypoparathyroidism Neuroendocrine tumor

Autosomal dominant disease Pain agnosia Hypertension Giant cell tumor

Arthritis Kidney failure Osteomalacia Parathyroid adenoma

10/96 Novoseek disease relationships for CALCA gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma medullary	95.9	364	1595326 (7), 19726541 (7), 19606248 (5), 2112816 (4) (see all 99)
osteoporosis	87.7	482	2035172 (7), 8837547 (6), 2188043 (4), 7917799 (4) (see all 99)
carcinoma medullary	87	64	15779075 (4), 7716641 (2), 9021721 (2), 1350867 (2) (see all 52)
osteoporosis postmenopausal	86.3	142	11810415 (3), 8154311 (3), 7748920 (3), 15293868 (3) (see all 99)
men 2a	86	40	8094268 (3), 7638742 (3), 12437249 (2), 1677783 (2) (see all 28)
multiple endocrine neoplasia	85.1	5	1351314 (1), 16472416 (1), 1971777 (1), 19606248 (1) (see all 5)
hypercalcemia	81.1	170	17681097 (4), 16143533 (4), 2137363 (4), 11225473 (3) (see all 99)
thyroid carcinoma, familial medullary	79.1	11	2112816 (1), 8099830 (1), 10474127 (1), 12437249 (1) (see all 11)
bone loss	78.9	165	10100579 (4), 8461542 (4), 1933614 (4), 8992875 (4) (see all 99)
thyroid nodule	69.6	33	18364376 (4), 9195818 (1), 15864423 (1), 19079272 (1) (see all 28)

Genetic Association Database (GAD): CALCA
Human Genome Epidemiology (HuGE) Navigator: CALCA (21 documents)

Export disorders for CALCA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CALCA gene, integrated from 9 sources (see all 3196):
(articles sorted by number of sources associating them with CALCA)

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The complete sequence of human preprocalcitonin. (PubMed id 6546550)^{1, 2, 3} le Moullec J.-M.... Moukhtar M.S. (1984)
Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer. (PubMed id 15880427)^{1, 4} Goodman M.T....Ness R.B. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women. (PubMed id 14627864)^{1, 4} Kim J.G....Lee J.Y. (2003)
Identification of four novel polymorphisms in the calcitonin/alpha-CGRP (CALCA) gene and an investigation of their possible associations with Parkinson disease, schizophrenia, and manic depression. (PubMed id 11317366)^{1, 4} Buervenich S....Olson L. (2001)
Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus. (PubMed id 11185743)^{1, 4} Miyao M....Ouchi Y. (2000)
A 1H NMR study of human calcitonin in solution. (PubMed id 2001366)^{1, 2} Motta A.... Bovermann G. (1991)
A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene. (PubMed id 1761559)^{1, 2} Minvielle S.... Lasmoles F. (1991)
Expression and function of the human calcitonin/alpha-CGRP gene in health and disease. (PubMed id 3034287)^{1, 2} Craig R.K.... Marshall I. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 796	HGNC: 1437	AceView: CALCA	Ensembl:ENSG00000110680	euGenes: HUgn796
ECgene: CALCA	H-InvDB: CALCA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CALCA	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/calca/
Wikipedia	http://en.wikipedia.org/wiki/Calcitonin

Intellectual Property for CALCA gene
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Patent Information for CALCA gene:
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GeneCards and IP:
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA

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CALCA Gene

calcitonin-related polypeptide alpha

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Migraine
Spinal Stenosis
sepsis
MEN 2a
THYROID CARCINOMA ANAPLASTIC
THYROID FOLLICULAR CARCINOMA
TRANSIENT REGIONAL OSTEOPOROSIS
Thyroid Nodule
Somatostatinoma
PARATHYROID ADENOMA
PAGETS BONE DISEASE
Bone Diseases
Headache including migraine
Fractures Pathological
Hyperparathyroidism Secondary
Cluster Headache
Hyperalgesia
THYROID CARCINOMA MEDULLARY
Apudoma
Hypophosphatemia
multinodular goiter
follicular thyroid cancer
bone loss
Complex Regional Pain Syndromes
Cherubism
Osteolysis
Hypercalcemia
MEN 3
Inflammation
Osteoporosis Postmenopausal
Thyroid Neoplasms
Bone Cysts Aneurysmal
Germ-Line Mutation
osteolytic
Insulinoma
OSTEOPOROSIS OSTEOPENIA
Hypoparathyroidism
Idiopathic osteoporosis
Pseudohypoparathyroidism
hormone deficiency
Osteopenia
Tumors
Metastasis
Pheochromocytoma
PHANTOM LIMB PAIN
hypercalciuria
Islet Cell Tumor
Cushing Syndrome
Bone Diseases Metabolic
Granuloma Giant Cell
Thyroiditis
Hypocalcemia
Adenoma Follicular
Hyperplasia
Goiter Nodular
Carcinoma Mucoepidermoid
Multiple Endocrine Neoplasia
Reflex Sympathetic Dystrophy
Central giant cell granuloma
Carcinoma
Osteoarthritis
Hyperparathyroidism
Algodystrophy
Thyroid Cancer
OSTEOCLASTOMA
Osteoporosis
WDHA syndrome
Carcinoma Papillary
Carcinoid
THYROID PAPILLARY CARCINOMA
Carcinoma Anaplastic
Paraganglioma
Goiter
PAGET DISEASE, JUVENILE
small cell lung cancer
Neuroendocrine Tumors
Adenoma Trabecular
GOITER ADENOMATOUS
Carcinoma Medullary
Giant Cell Tumors
Thyroid Diseases
HYPERPARATHYROIDISM PRIMARY
Neuroma
THYROID CARCINOMA, FAMILIAL MEDULLARY
liver metastases
Disuse osteoporosis
Thyroiditis Chronic
Hashimotos Thyroiditis
Renal Osteodystrophy
Carcinoma Neuroendocrine
Osteomalacia
BONE DESTRUCTION
Other osteoporosis
THYROID CARCINOMA
bone metastases
Hypogonadism

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CALCA Gene

calcitonin-related polypeptide alpha

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