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CALCA Gene

protein-coding GIFtS: 68

GC11M014945

calcitonin-related polypeptide alpha
(Previous name: calcitonin 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CALC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CALC1 ^², ³, ⁵
CGRP ^²
CGRP-I ^², ³
CGRP1 ^²
CT ^²
KC ^²
MGC126648 ^²
calcitonin ^²
katacalcin ^²

Descriptions
Alpha-type CGRP ^³
Calcitonin gene-related peptide I ^³
calcitonin 1 ^¹, ²
calcitonin-related polypeptide alpha ^²
calcitonin/calcitonin-related polypeptide, alpha ^²

External Ids
HGNC: 1437¹
Entrez Gene: 796²
UniProtKB: P06881³
UniProtKB: P01258³
Ensembl: ENSG00000110680⁷

Search outside databases for aliases for CALCA gene

Previous GC identifers: GC11M016170 GC11M015736 GC11M015027 GC11M014952

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CALCA:

Calcitonin is a peptide hormone synthesized by the parafollicular cells of the thyroid. It causes

reduction in serum calcium, an effect opposite to that of parathyroid hormone (PTH; MIM

168450).[supplied by OMIM]

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Function: Katacalcin is a potent plasma calcium-lowering peptide

Gene Wiki entry for CALCA (Calcitonin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CALCA gene

Entrez Gene cytogenetic band: 11p15.2-p15.1 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15.2

CALCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M014945: (about GC identifiers)

Start:	14,944,792 bp from pter
End:	14,950,408 bp from pter
Size:	5,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881 (See protein sequence)

Recommended Name: Calcitonin gene-related peptide 1 precursor

Size: 128 amino acids; 13899 Da

PDB structures from and Proteopedia :

1LS7 (3D)

Secondary accessions: Q93048 Q9UCP0

Alternative splicing: 3 isoforms: P06881-1 P01258-1 P01258-2

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258 (See protein sequence)

Recommended Name: Calcitonin precursor

Size: 141 amino acids; 15467 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

2JXZ (3D)

Secondary accessions: Q13935 Q13937 Q52LX7

Alternative splicing: 3 isoforms: P01258-1 P01258-2 P06881-1

REFSEQ proteins (3 alternative transcripts):

NP_001029124.1 NP_001029125.1 NP_001732.1

ENSEMBL proteins:

ENSP00000379657 ENSP00000331746 ENSP00000352663 ENSP00000354286 ENSP00000379659

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CALCA
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CALCA
	Recombinant Proteins from Abcam (Calcitonin, Procalcitonin, CGRP)
	Human Recombinant Proteins from Abnova (CALCA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	2408883 18057382
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	17267696

About this table

Antibodies for CALCA:

	Invitrogen Antibodies for CALCA
	Millipore Mono- and Polyclonal Antibodies for the study of CALCA
	Sigma-Aldrich Antibodies for CALCA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Calcitonin, Procalcitonin, CGRP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CALCA)
	Novus Biologicals Antibodies for CALCA

Assays for CALCA:

	Invitrogen Assays for CALCA
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06881

Graphical View of Domain Structure for InterPro Entry P01258

ProtoNet protein and cluster: P06881

2 Blocks protein families:

IPB000443 Islet amyloid protein (amylin) signature

IPB002163 Beta-type calcitonin signature

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881

Similarity: Belongs to the calcitonin family

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Similarity: Belongs to the calcitonin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CALCA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CALCA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001741

Applied Biosystems Silencer® siRNAs for CALCA

Sigma-Aldrich siRNA and siRNA Panels for CALCA

Sigma-Aldrich shRNA for CALCA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CALCA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033952
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033952
untagged cDNA clones in CMV expression vector (see all 3): NM_001033952

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001741

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881

Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary,

cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter

or neuromodulator role. It also elevates platelet cAMP

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258

Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in

blood by promoting the incorporation of those ions in the bones

Function: Katacalcin is a potent plasma calcium-lowering peptide

Genatlas biochemistry entry for CALCA:

calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the

same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of

Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of

the nervous and endocrine system,potent vasodilatator and hypotensor

8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Calca):

	embryogenesis	hearing/vestibular/ear	homeostasis/metabolism	nervous system
renal/urinary system	respiratory system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0031716	calcitonin receptor binding	IPI	8078488 8940110

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CALCA

5/82 Interacting proteins for CALCA (ENSP00000331746³ P01258²) via UniProtKB, MINT, and/or STRING (see all 82 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP2B2	Q01814²	MINT-5204027 MINT-5203983
ATP2B4	P23634²	MINT-5204003 MINT-5203983
CALCR	ENSP00000353385³	STRING (score=.993)
ADM	ENSP00000278175³	STRING (score=.989)
RAMP2	ENSP00000253796³	STRING (score=.984)

About this table

5/33 Gene Ontology (GO) biological process terms (links to tree view) (see all 33 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001935	endothelial cell proliferation	IDA	17267696
GO:0001944	vasculature development	IDA	17267696
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	IDA	10642343
GO:0001984	vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure	IEA	--
GO:0002027	regulation of heart rate	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CALCA available from Tocris Bioscience

Compound	Action	CAS number
CGRP 8-37 (human)	CGRP1 receptor antagonist	[119911-68-1]
CGRP 8-37 (rat)	CGRP1 receptor antagonist
PHM 27 (human)	Potent calcitonin receptor agonist; endogenous analog of human VIP	[118025-43-7]
CGRP (rat)	Potent vasodilator	[96827-03-1]
SUN-B 8155	Non-peptide calcitonin (CT) receptor agonist	[345893-91-6]

About this table

10/29 Novoseek chemical compound relationships for CALCA gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	88.26	44	10711339 (4), 11755165 (2), 10988349 (2), 11804624 (2) (see all 24)
calcium	80.58	1167	16014619 (9), 11695068 (6), 9440370 (6), 10707893 (6) (see all 99)
elcatonin	76.66	40	10220278 (5), 7669941 (3), 8181470 (2), 17707708 (2) (see all 13)
hydroxyproline	67.63	33	8339504 (3), 2389624 (2), 1796722 (2), 1818759 (1) (see all 28)
strontium ranelate	67.30	11	15170434 (1), 16301192 (1), 17477926 (1), 16709313 (1) (see all 11)
ac 187	66.28	3	10433998 (1), 10205019 (1)
1-piperidinecarboxamide	65.56	1	15464043 (1)
i-app	64.70	77	9221931 (7), 1876601 (6), 8323757 (4), 7802654 (4) (see all 24)
denosumab	63.81	3	19249985 (1), 19028360 (1)
amylinamide	63.18	4	2223054 (3), 8182554 (1)

About this table

1 PharmGKB drug compound relationship for CALCA gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
estrogens,conjugated	PD GN	14627864

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CALCA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CALCA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001741

Sigma-Aldrich siRNA and siRNA Panels for CALCA

Sigma-Aldrich shRNA for CALCA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001033952 NM_001033953 NM_001741

REFSEQ mRNAs for CALCA gene (3 alternative transcripts):

NM_001033952.1 NM_001033953.1 NM_001741.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001033952 NM_001033953 NM_001741

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033952
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033952
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001033952

Additional cDNA sequence:

BC069684.1 BC069704.1 BC069760.1 BC069778.1 BC093753.1 BC101599.1 BC143562.1 K03512.1

K03513.1 M26095.1 M64486.1 X00356.1 X02330.1 X03662.1

4 DOTS entries:

DT.86840457 DT.100016988 DT.111153 DT.102824295

24/43 AceView cDNA sequences (see all 43 ):

BX094781 AW296074 M64486 BC069760 BF447272 X00356 AI695720 NM_001741

X03662 BC069704 CD612756 BF942171 X02330 BC069778 M26095 BC069684

CB048118 CD612752 CD612754 BF942434 K03512 AA716058 BF942073 CB048117

highest scoring ESTs for CALCA:

BC069684 BC069704 BC069760 BC069778 CD612752 CD612756 M26095 M64486 X00356 X03662

Unigene Cluster for CALCA:

Calcitonin-related polypeptide alpha

Hs.37058 [show with all ESTs]

Unigene Representative Sequence: X02330

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CALCA

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for CALCA

5 Ensembl transcripts including schematic representations:

ENST00000396372 ENST00000331587 ENST00000359642 ENST00000361010 ENST00000396374

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CALCA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CALCA

¹ / ² / ³

10 probe-sets matching CALCA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36300_at²^{, 3}	U95-A	1	1.00	1.00	0.57	0.50	X15943	0.20	1.00	0.72	1
36299_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X02330	0.60	1.00	0.82	1
217561_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF447272	0.60	1.00	0.82	1
210727_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M26095	0.80	1.00	0.91	1
210728_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M26095	0.80	1.00	0.91	1
217495_x_at²^{, 3}	U133-A	2	1.00	0.82	--	--	X15943	0.20	1.00	0.72	1
217561_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210727_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210728_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217495_x_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--

GeneDecks CALCA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAATGCTGT

SOURCE GeneReport for Unigene cluster: Hs.37058
Expression variation in blood from EXPOLDB for CALCA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CALCA gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRSP-2¹	--	calcitonin receptor-stimulating peptide-2	74.54(n) 59.06(a)	403414 NM_001002947.1 NP_001002947.1
mouse (Mus musculus)	Calca⁵	7 (54.00 cM)	calcitonin/calcitonin-related polypeptide, alpha	--	X97991

About this table Species with no ortholog for CALCA

ENSEMBL Gene Tree for CALCA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CALCA gene

CALCB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/75 NCBI SNPs in CALCA are shown (see all 75 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3781719^1,2	A,C,F,H	14951100(-)	`TGAGAT/CTGTGG`	3	--	ng3¹		9	NS EU EA WA	588
	rs1553005^1,2	A,C,F,H	14951066(+)	`cagagG/Cctcag`	3	--	ng3¹		10	EU EA WA NA NS	659
	rs2644690^1,2	C,F,H	14950352(+)	`GCCAGA/GATCTC`	3	--	ut5¹ int¹ ese³		4	EU EA WA	418
	rs13306224^1,2	C,F,H	14946934(+)	`CATTCT/GGGGGC`	3	P/Q	mis¹ int¹ ese³		9	EU EA WA NS	604
	rs5241^1,2	C,F,H	14947119(-)	`TGCAGC/ACTGGA`	3	R/S	mis¹ int¹		18	MN NA NS EU EA WA	1328
	rs924099^1,2	C,F,H	14951186(+)	`CCGCAT/CAGGGG`	3	--	ng3¹		5	EU EA WA NA	510
	rs5239^1,2	C,F,H	14948115(-)	`TGCAGG/AACTAT`	3	N/D	mis¹ ese³		7	MN EU EA WA NA	754
	rs3781718^1,2	C,F,H	14951114(-)	`ATATTC/ACTTCA`	3	--	ng3¹		9	EU EA WA NS	586
	rs3758761^1,2	C,F	14951914(+)	`CACAGC/GGTCCA`	3	--	ng3¹		9	EA NA NS	1598
	rs34901084^1,2	F,H	14946482(-)	`AGCAGG/CAAGAA`	3	--	ng5¹ int¹		8	EU EA NS	490

About this table

HapMap Linkage Disequilibrium images for CALCA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114130

10/96 Novoseek disease relationships for CALCA gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma medullary	95.66	331	1595326 (7), 2112816 (4), 11735017 (4), 17051143 (4) (see all 99)
osteoporosis	87.83	477	2035172 (7), 8837547 (6), 2188043 (4), 7917799 (4) (see all 99)
carcinoma medullary	87.02	62	15779075 (4), 1350867 (2), 7716641 (2), 9021721 (2) (see all 51)
osteoporosis postmenopausal	86.50	140	11810415 (3), 8154311 (3), 7748920 (3), 15293868 (3) (see all 99)
men 2a	84.72	38	8094268 (3), 7638742 (3), 12437249 (2), 1677783 (2) (see all 27)
multiple endocrine neoplasia	83.75	4	1351314 (1), 16472416 (1), 1971777 (1), 1352395 (1)
hypercalcemia	81.31	166	17681097 (4), 16143533 (4), 2137363 (4), 11225473 (3) (see all 99)
bone loss	79.24	165	10100579 (4), 8461542 (4), 1933614 (4), 8992875 (4) (see all 99)
thyroid carcinoma, familial medullary	78.94	11	2112816 (1), 8099830 (1), 10474127 (1), 12437249 (1) (see all 11)
hyperparathyroidism	68.29	9	15526839 (2), 7752492 (1), 8966142 (1), 9387131 (1) (see all 7)

About this table

Human Gene Mutation Database: CALCA
Genetic Association Database: CALCA
Human Genome Epidemiology Navigator: CALCA (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2245 PubMed articles for CALCA gene (see all 2245 ):

Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women. (PubMed id 14627864)^{3, 6, 7} Kim J.G....Lee J.Y. (2003)
The complete sequence of human preprocalcitonin. (PubMed id 6546550)^{2, 3, 4} le Moullec J.-M.... Moukhtar M.S. (1984)
Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer. (PubMed id 15880427)^{3, 6} Goodman M.T....Ness R.B. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of four novel polymorphisms in the calcitonin/alpha-CGRP (CALCA) gene and an investigation of their possible associations with Parkinson disease, schizophrenia, and manic depression. (PubMed id 11317366)^{3, 6} Buervenich S....Olson L. (2001)
Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus. (PubMed id 11185743)^{3, 6} Miyao M....Ouchi Y. (2000)
A 1H NMR study of human calcitonin in solution. (PubMed id 2001366)^{3, 4} Motta A.... Bovermann G. (1991)
A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene. (PubMed id 1761559)^{3, 4} Minvielle S.... Lasmoles F. (1991)
Structure and methylation of the human calcitonin/alpha-CGRP gene. (PubMed id 2571128)^{3, 4} Broad P.M.... Craig R.K. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 796	HGNC: 1437	AceView: CALCA	Ensembl:ENSG00000110680	euGenes: HUgn796
ECgene: CALCA	H-InvDB: CALCA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/calca/
Wikipedia	http://en.wikipedia.org/wiki/Calcitonin

Licensable Technologies for CALCA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CALCA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CALCA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CALCA		Antibodies for CALCA
	Explore super-pooled esiRNAs		Proteins for CALCA
	Lentivirus-delivered shRNAs for CALCA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CALCA)
	Antibodies (CALCA)
	Chimera RNAi (CALCA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Calcitonin, Procalcitonin, CGRP)
	Antibodies (Calcitonin, Procalcitonin, CGRP)

Search OriGene for CALCA

Tocris compounds for CALCA

	Proteins for CALCA
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CALCA

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CALCA Gene at Home site.
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CALCA Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CALCA

Summaries
for CALCA

Genomic Location
for CALCA

Proteins
for CALCA

Protein Domains/
Families
for CALCA

Gene Function
for CALCA

Pathways & Interactions
for CALCA

Drugs & Compounds
for CALCA

Transcripts
for CALCA

Expression
for CALCA

Orthologs
for CALCA

Paralogs
for CALCA

SNPs/Variants
for CALCA

Disorders & Mutations
for CALCA

Medical News
for CALCA

Publications
for CALCA

Search for CALCA

Genome Databases showing CALCA

Other Databases showing CALCA

Specialized Databases showing CALCA

Licensable Technologies
for CALCA

Services
for CALCA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CALCA Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CALCA

Summariesfor CALCA

Genomic Locationfor CALCA

Proteinsfor CALCA

Protein Domains/Familiesfor CALCA

Gene Functionfor CALCA

Pathways & Interactionsfor CALCA

Drugs & Compoundsfor CALCA

Transcriptsfor CALCA

Expression for CALCA

Orthologsfor CALCA

Paralogsfor CALCA

SNPs/Variantsfor CALCA

Disorders & Mutationsfor CALCA

Medical Newsfor CALCA

Publicationsfor CALCA

Search for CALCA

Genome Databases showing CALCA

Other Databases showing CALCA

Specialized Databases showing CALCA

Licensable Technologiesfor CALCA

Servicesfor CALCA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CALCA

Summaries
for CALCA

Genomic Location
for CALCA

Proteins
for CALCA

Protein Domains/
Families
for CALCA

Gene Function
for CALCA

Pathways & Interactions
for CALCA

Drugs & Compounds
for CALCA

Transcripts
for CALCA

Expression
for CALCA

Orthologs
for CALCA

Paralogs
for CALCA

SNPs/Variants
for CALCA

Disorders & Mutations
for CALCA

Medical News
for CALCA

Publications
for CALCA

Licensable Technologies
for CALCA

Services
for CALCA