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Aliases for CALCA Gene

Aliases for CALCA Gene

  • Calcitonin-Related Polypeptide Alpha 2 3
  • CALC1 3 4 6
  • Calcitonin Gene-Related Peptide I 3 4
  • Alpha-Type CGRP 3 4
  • Calcitonin 1 2 3
  • Calcitonin 2 3
  • CGRP-I 3 4
  • Calcitonin/Calcitonin-Related Polypeptide, Alpha 3
  • Katacalcin 3
  • CGRP1 3
  • CGRP 3
  • CT 3
  • KC 3

External Ids for CALCA Gene

Previous Symbols for CALCA Gene

  • CALC1

Summaries for CALCA Gene

Entrez Gene Summary for CALCA Gene

  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

GeneCards Summary for CALCA Gene

CALCA (Calcitonin-Related Polypeptide Alpha) is a Protein Coding gene. Diseases associated with CALCA include paroxysmal hemicrania and discitis. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include identical protein binding and protein complex binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot for CALCA Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

  • Katacalcin is a potent plasma calcium-lowering peptide

Gene Wiki entry for CALCA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCA Gene

Genomics for CALCA Gene

Genomic Location for CALCA Gene

Start:
14,966,668 bp from pter
End:
14,972,354 bp from pter
Size:
5,687 bases
Orientation:
Minus strand

Genomic View for CALCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCA Gene

Regulatory Elements for CALCA Gene

Transcription factor binding sites by QIAGEN in the CALCA gene promoter:

Proteins for CALCA Gene

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01258-CALC_HUMAN
    Recommended name:
    Calcitonin
    Protein Accession:
    P01258
    Secondary Accessions:
    • B7ZL39
    • Q13935
    • Q13937
    • Q52LX7

    Protein attributes for CALCA Gene

    Size:
    141 amino acids
    Molecular mass:
    15466 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06881-CALCA_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 1
    Protein Accession:
    P06881
    Secondary Accessions:
    • Q93048
    • Q9UCP0

    Protein attributes for CALCA Gene

    Size:
    128 amino acids
    Molecular mass:
    13898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCA Gene

Proteomics data for CALCA Gene at MOPED

Post-translational modifications for CALCA Gene

Other Protein References for CALCA Gene

No data available for DME Specific Peptides for CALCA Gene

Domains for CALCA Gene

Gene Families for CALCA Gene

HGNC:

UniProtKB/Swiss-Prot:

CALCA_HUMAN
Family:
  • Belongs to the calcitonin family.:
    • P06881
  • Belongs to the calcitonin family.:
    • P01258
genes like me logo Genes that share domains with CALCA: view

Function for CALCA Gene

Molecular function for CALCA Gene

GENATLAS Biochemistry: calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
UniProtKB/Swiss-Prot Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones
UniProtKB/Swiss-Prot Function: Katacalcin is a potent plasma calcium-lowering peptide

Gene Ontology (GO) - Molecular Function for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 16014619
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 17689535
GO:0031716 calcitonin receptor binding IPI 8078488
GO:0032403 protein complex binding IDA 14722252
genes like me logo Genes that share ontologies with CALCA: view
genes like me logo Genes that share phenotypes with CALCA: view

Animal Models for CALCA Gene

MGI Knock Outs for CALCA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CALCA Gene

Localization for CALCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCA Gene COMPARTMENTS Subcellular localization image for CALCA gene
Compartment Confidence
extracellular 5
cytoskeleton 3
nucleus 3
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18057382
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CALCA: view

Pathways for CALCA Gene

genes like me logo Genes that share pathways with CALCA: view

Pathways by source for CALCA Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CALCA Gene
2 BioSystems pathways for CALCA Gene

Gene Ontology (GO) - Biological Process for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation IDA 17267696
GO:0001944 vasculature development IDA 17267696
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure IDA 10642343
GO:0001984 vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0002027 regulation of heart rate IEA --
genes like me logo Genes that share ontologies with CALCA: view

Compounds for CALCA Gene

(5) Tocris Compounds for CALCA Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP 8-37 (human) CGRP1 receptor antagonist [119911-68-1]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(2) HMDB Compounds for CALCA Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4

(130) Novoseek inferred chemical compound relationships for CALCA Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 89.1 33
alendronate 83.8 152
vitamin d 83.1 123
etidronate 83 101
raloxifene 80.9 113
genes like me logo Genes that share compounds with CALCA: view

Transcripts for CALCA Gene

Unigene Clusters for CALCA Gene

Calcitonin-related polypeptide alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALCA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for CALCA Gene

GeneLoc Exon Structure for
CALCA
ECgene alternative splicing isoforms for
CALCA

Expression for CALCA Gene

mRNA expression in normal human tissues for CALCA Gene

mRNA differential expression in normal tissues according to GTEx for CALCA Gene

This gene is overexpressed in Thyroid (23.1) and Liver (15.7).

SOURCE GeneReport for Unigene cluster for CALCA Gene Hs.37058

genes like me logo Genes that share expressions with CALCA: view

Orthologs for CALCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCA 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALCA 36
  • 75.15 (n)
  • 64.04 (a)
CT 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRSP-2 37
  • 72 (a)
OneToMany
CRSP-3 36
  • 75.07 (n)
  • 59.06 (a)
CRSP-3 37
  • 68 (a)
OneToMany
CRSP1 37
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Calca 16
Calca 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves CALCA 37
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii calca 37
  • 45 (a)
OneToMany
Species with no ortholog for CALCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCA Gene

ENSEMBL:
Gene Tree for CALCA (if available)
TreeFam:
Gene Tree for CALCA (if available)

Paralogs for CALCA Gene

Paralogs for CALCA Gene

Selected SIMAP similar genes for CALCA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CALCA Gene

genes like me logo Genes that share paralogs with CALCA: view

Variants for CALCA Gene

Sequence variations from dbSNP and Humsavar for CALCA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2956 -- 14,967,575(-) TAAAA(A/T)ATCCA intron-variant
rs5237 -- 14,971,910(-) GGGAC(A/G)GCGTC intron-variant
rs5238 -- 14,971,787(-) CAGGC(G/T)CTGGG intron-variant
rs5239 -, - 14,969,993(-) TGCAG(A/G)ACTAT missense, reference
rs5240 -- 14,969,985(-) TATGT(G/T)CAGAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CALCA Gene

Variant ID Type Subtype PubMed ID
nsv832071 CNV Loss 17160897
nsv897006 CNV Gain 21882294
nsv897007 CNV Gain 21882294
nsv897008 CNV Loss 21882294

Relevant External Links for CALCA Gene

HapMap Linkage Disequilibrium report
CALCA
Human Gene Mutation Database (HGMD)
CALCA

Disorders for CALCA Gene

(96) Novoseek inferred disease relationships for CALCA Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma medullary 95.9 168
osteoporosis 87.7 204
carcinoma medullary 87 59
osteoporosis postmenopausal 86.3 128
men 2a 86 35

Relevant External Links for CALCA

Genetic Association Database (GAD)
CALCA
Human Genome Epidemiology (HuGE) Navigator
CALCA
genes like me logo Genes that share disorders with CALCA: view

No data available for UniProtKB/Swiss-Prot for CALCA Gene

Publications for CALCA Gene

  1. The complete sequence of human preprocalcitonin. (PMID: 6546550) le Moullec J.-M. … Moukhtar M.S. (FEBS Lett. 1984) 2 3 4
  2. Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women. (PMID: 14627864) Kim J.G. … Lee J.Y. (Menopause 2003) 3 49
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  4. Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer. (PMID: 15880427) Goodman M.T. … Ness R.B. (Environ. Mol. Mutagen. 2005) 3 49
  5. Association of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican women. (PMID: 17026622) MagaA+a J.J. … ValdAcs M. (Clin. Genet. 2006) 3 49

Products for CALCA Gene

Sources for CALCA Gene

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