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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALCA Gene

protein-coding   GIFtS: 67
GCID: GC11M014945

Calcitonin-Related Polypeptide Alpha

(Previous name: calcitonin 1)
(Previous symbol: CALC1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcitonin-Related Polypeptide Alpha1 2     CGRP2
CALC11 2 3 5     CGRP12
Calcitonin 11 2     CT2
calcitonin1 2     KC2
Alpha-Type CGRP2 3     Calcitonin/Calcitonin-Related Polypeptide, Alpha2
Calcitonin Gene-Related Peptide I2 3     katacalcin2
CGRP-I2 3     

External Ids:    HGNC: 14371   Entrez Gene: 7962   Ensembl: ENSG000001106807   OMIM: 1141305   UniProtKB: P068813   
UniProtKB: P012583   

Export aliases for CALCA gene to outside databases

Previous GC identifers: GC11M016170 GC11M015736 GC11M015027 GC11M014952 GC11M014671


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALCA Gene:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by
tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins.
Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related
peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants
encoding different isoforms have been found for this gene.(provided by RefSeq, Nov 2009)

GeneCards Summary for CALCA Gene: 
CALCA (calcitonin-related polypeptide alpha) is a protein-coding gene. Diseases associated with CALCA include complex regional pain syndrome, and spinal stenosis, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include hormone activity and receptor binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by
promoting the incorporation of those ions in the bones
Function: Katacalcin is a potent plasma calcium-lowering peptide

Gene Wiki entry for CALCA (Calcitonin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALCA gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCA promoter sequence
   Search SABiosciences Chromatin IP Primers for CALCA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

CALCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M014945:  view genomic region     (about GC identifiers)

Start:
14,988,214 bp from pter      End:
14,993,900 bp from pter
Size:
5,687 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881 (See protein sequence)
Recommended Name: Calcitonin gene-related peptide 1 precursor  
Size: 128 amino acids; 13898 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CALCA:
1LS7 (3D)    
Secondary accessions: Q93048 Q9UCP0
Alternative splicing: 3 isoforms:  P06881-1   P01258-1   P01258-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258 (See protein sequence)

Recommended Name: Calcitonin precursor  
Size: 141 amino acids; 15466 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CALCA:
2JXZ (3D)    
Secondary accessions: B7ZL39 Q13935 Q13937 Q52LX7
Alternative splicing: 3 isoforms:  P01258-1   P01258-2   P06881-1   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CALCA: NX_P01258

Explore proteomics data for CALCA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01258

  • CALCA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALCA Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001029124.1  NP_001029125.1  NP_001732.1  

    ENSEMBL proteins: 
     ENSP00000417833   ENSP00000420618   ENSP00000331746   ENSP00000379657   ENSP00000354286  
     ENSP00000352663  
    Reactome Protein details: P06881 P01258
    Human Recombinant Protein Products for CALCA: 
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    OriGene MassSpec for CALCA 
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    Novus Biologicals CALCA Proteins
    Novus Biologicals CALCA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CALCA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18057382
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    CALCA for ontologies           About GeneDecksing



    CALCA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALCA
    Browse R&D Systems for Antibodies
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    Novus Biologicals CALCA Antibodies
    Abcam antibodies for CALCA (P06881, P01258)
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CALCA
    LSBio Antibodies in human, mouse, rat for CALCA 

    Assay Products for CALCA: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    5/6 InterPro protein domains (see all 6):
     IPR021118 Procalcitonin_A-typ
     IPR018360 Calcitonin_CS
     IPR015476 Procalcitonin_gene-rel_peptide
     IPR001693 Calcitonin_peptide-like
     IPR021116 Procalcitonin/adrenomedullin

    Graphical View of Domain Structure for InterPro Entry P06881
    Graphical View of Domain Structure for InterPro Entry P01258

    ProtoNet protein and cluster: P06881

    2 Blocks protein domains:
    IPB000443 Islet amyloid protein (amylin) signature
    IPB002163 Beta-type calcitonin signature


    UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881
    Similarity: Belongs to the calcitonin family

    UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
    Similarity: Belongs to the calcitonin family


    CALCA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALCA_HUMAN, P06881
    Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic
    vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also
    elevates platelet cAMP

         UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
    Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by
    promoting the incorporation of those ions in the bones
    Function: Katacalcin is a potent plasma calcium-lowering peptide

         Genatlas biochemistry entry for CALCA:
    calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same
    gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and
    PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine
    system,potent vasodilatator and hypotensor

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IDA16014619
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI17689535
    GO:0031716calcitonin receptor binding IPI8078488
    GO:0032403protein complex binding IDA14722252
         
    CALCA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALCA:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Calca):
     behavior/neurological  cardiovascular system  embryogenesis  hearing/vestibular/ear  homeostasis/metabolism 
     integument  mortality/aging  nervous system  normal  renal/urinary system 
     respiratory system  skeleton  tumorigenesis 

    CALCA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CALCA: Calcatm1Hku Calcatm1Rfg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALCA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALCA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCA 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCA
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCA:
    hsa-miR-374b* hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCALCA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CALCA

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALCA (see all 16)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCA (NM_001033953)
    Sino Biological Human cDNA Clone for CALCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA
    Sirion Biotech Customized lentivirus for stable overexpression of CALCA 
                         Customized lentivirus expression plasmids for stable overexpression of CALCA 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALCA About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    Class B/2 (Secretin family receptors)0.36
    G alpha (s) signalling events0.31
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    4Calcitonin-like ligand receptors
    Calcitonin-like ligand receptors
    5Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CALCA
        Adenylate cyclase-activating neuropeptides
    Transcription Role of VDR in regulation of genes involved in osteoporosis


    1 GeneGo (Thomson Reuters) Pathway for CALCA
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALCA
        Myometrial Relaxation and Contraction Pathways
    Endothelin


    5/9        Reactome Pathways for CALCA (see all 9)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Disease
    Amyloids



    CALCA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for CALCA (P012581, 2, 3 ENSP000003317464) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2B2Q018142, ENSP000003241724MINT-5204027 MINT-5203983 STRING: ENSP00000324172
    ATP2B4P236342, ENSP000003503104MINT-5204003 MINT-5203983 STRING: ENSP00000350310
    CALCAP012582MINT-8409770 MINT-8409885 MINT-8409840
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001935endothelial cell proliferation IDA17267696
    GO:0001944vasculature development IDA17267696
    GO:0001976neurological system process involved in regulation of systemic arterial blood pressure IDA10642343
    GO:0001984vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA--
    GO:0002027regulation of heart rate IEA--

    CALCA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALCA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CALCA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    2 HMDB Compounds for CALCA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10/130 Novoseek inferred chemical compound relationships for CALCA gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 89.1 46 10711339 (4), 11755165 (2), 10988349 (2), 11804624 (2) (see all 25)
    alendronate 83.8 171 15032563 (10), 11695068 (6), 16523336 (6), 15607319 (6) (see all 99)
    vitamin d 83.1 261 15846740 (4), 10446876 (3), 12162505 (3), 2038639 (2) (see all 99)
    etidronate 83 112 9205627 (8), 15465502 (4), 8538482 (4), 8608360 (4) (see all 71)
    raloxifene 80.9 121 12708951 (3), 10943237 (3), 17376323 (3), 14557222 (3) (see all 99)
    risedronate 80.6 73 15032563 (11), 8592950 (5), 17227729 (2), 13680313 (2) (see all 49)
    calcium 80.6 1188 16014619 (9), 11695068 (6), 9440370 (6), 10707893 (6) (see all 99)
    calogen 80.2 14 9008693 (1), 15167766 (1), 9221486 (1), 2020925 (1) (see all 11)
    teriparatide 79.6 50 16709314 (7), 16421647 (5), 18413693 (3), 15167766 (1) (see all 33)
    elcatonin 76.9 42 10220278 (5), 7669941 (3), 8181470 (2), 17707708 (2) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CALCA / CALC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CALCA gene (3 alternative transcripts): 
    NM_001033952.2  NM_001033953.2  NM_001741.2  

    Unigene Cluster for CALCA:

    Calcitonin-related polypeptide alpha
    Hs.37058  [show with all ESTs]
    Unigene Representative Sequence: X02330
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486207 ENST00000494746(uc001mlv.1 uc001mlw.1) ENST00000469608
    ENST00000331587 ENST00000396372 ENST00000361010(uc001mlt.2 uc001mlu.2)
    ENST00000359642
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCA:
    hsa-miR-374b* hsa-miR-3657
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CALCA (NM_001033953)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA
    Sirion Biotech Customized lentivirus for stable overexpression of CALCA 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCA

    Additional mRNA sequence: 

    BC069684.1 BC069704.1 BC069760.1 BC069778.1 BC093753.1 BC101599.1 BC143562.1 K03512.1 
    K03513.1 M26095.1 M64486.1 X00356.1 X02330.1 X03662.1 

    4 DOTS entries:

    DT.86840457  DT.100016988  DT.111153  DT.102824295 

    24/43 AceView cDNA sequences (see all 43):

    AW296074 BX094781 X02330 BC069760 X03662 M26095 BC069778 X00356 
    BC069684 AI695720 BF942171 BF447272 CD612756 M64486 BC069704 NM_001741 
    BF942434 K03512 CD612754 CB048118 CD612752 AA716058 BF942101 BF942024 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CALCA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for CALCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALCA expression in normal human tissues (normalized intensities)      CALCA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATGCTGT
    CALCA Expression
    About this image


    CALCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Globus Pallidus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Trigeminal Ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Superior Cervical Ganglion   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Neuroendocrine Cells Trachea
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells

    See CALCA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALCA

    SOURCE GeneReport for Unigene cluster: Hs.37058
        SABiosciences Expression via Pathway-Focused PCR Arrays including CALCA: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Obesity in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CALCA
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CALCA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CALCA gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calca1 , 5 calcitonin/calcitonin-related polypeptide, alpha1, 5 84.73(n)1
    79.39(a)1
      7 (59.99 cM)5
    123101  NM_007587.21  NP_031613.21 
     1146314805 
    chicken
    (Gallus gallus)
    Aves CALCA1 calcitonin-related polypeptide alpha 65.3(n)
    53.28(a)
      396256  XM_420997.2  XP_420997.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    possible ortholog
    1(64833205-64838856)
    zebrafish
    (Danio rerio)
    Actinopterygii calca6
    calcitonin/calcitonin-related polypeptide, alpha
    31(a)
    1 → many
    7(28806424-28811889)


    ENSEMBL Gene Tree for CALCA (if available)
    TreeFam Gene Tree for CALCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALCA gene
    CALCB2  
    2 SIMAP similar genes for CALCA using alignment to 2 protein entries:     CALCA_HUMAN (see all proteins):
    CALCB    IAPP

    CALCA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CALCA
    PGOHUM00000242602


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in CALCA are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0485844
    ----see VAR_0485842 N D mis40--------
    VAR_0145924
    ----see VAR_0145922 N D mis40--------
    rs110234001,2
    C,F,A--14911058(+) GTGAAG/ATATGT 1 -- ds50018Minor allele frequency- A:0.21NA CSA WA EA 368
    rs1412818851,2
    --14911084(+) ACCTAC/TTGCTG 1 -- ds50010--------
    rs1818598501,2
    --14911127(+) AGAATA/GAAAAA 1 -- ds50010--------
    rs1451171341,2
    --14911217(+) AGGCTA/GAGGGG 1 -- ds50010--------
    rs734205901,2
    C,F--14911227(+) GTGCAT/AGAAGA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs110234011,2
    C,F,A--14911245(+) ATATGG/CAGGAA 1 -- ds500110Minor allele frequency- C:0.22NA CSA WA EA 549
    rs1863470001,2
    --14911264(+) ATGGGC/TAAAGG 1 -- ds50010--------
    rs118266911,2
    C,H--14911275(+) CAAACC/TTGCAT 1 -- ds50012Minor allele frequency- T:0.03NA 67

    HapMap Linkage Disequilibrium report for CALCA (14988214 - 14993900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CALCA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897008CNV Loss21882294
    nsv832071CNV Loss17160897
    nsv897007CNV Gain21882294
    nsv897006CNV Gain21882294


    Human Gene Mutation Database (HGMD): CALCA
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CALCA
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114130    OMIM disorders: --

    20/312 diseases for CALCA (see all 312):    About MalaCards
    complex regional pain syndrome    spinal stenosis    aneurysmal bone cysts    reflex sympathetic dystrophy
    apudoma    paroxysmal hemicrania    cerebral arteriosclerosis    sepsis in premature infants
    duodenal endocrine tumor    amyloid tumor    headache    familial medullary thyroid carcinoma
    multiple endocrine neoplasia type 2a    cluster headache    wdha syndrome    complex regional pain syndrome type 1
    giant cell reparative granuloma    bone density    osteoporosis, postmenopausal    prurigo nodularis

    20/28 diseases from the University of Copenhagen DISEASES database for CALCA (see all 28):
    Thyroid cancer     Osteoporosis     Migraine     Hypercalcemia
    Paget's disease of bone     Hyperparathyroidism     Carcinoma     Complex regional pain syndrome
    Goiter     Neuroendocrine tumor     Breast cancer     Hypoparathyroidism
    Autosomal dominant disease     Pain agnosia     Hypertension     Kidney failure
    Giant cell tumor     Arthritis     Phaeochromocytoma     Adenoma

    CALCA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for CALCA gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 95.9 364 1595326 (7), 19726541 (7), 19606248 (5), 2112816 (4) (see all 99)
    osteoporosis 87.7 482 2035172 (7), 8837547 (6), 2188043 (4), 7917799 (4) (see all 99)
    carcinoma medullary 87 64 15779075 (4), 7716641 (2), 9021721 (2), 1350867 (2) (see all 52)
    osteoporosis postmenopausal 86.3 142 11810415 (3), 8154311 (3), 7748920 (3), 15293868 (3) (see all 99)
    men 2a 86 40 8094268 (3), 7638742 (3), 12437249 (2), 1677783 (2) (see all 28)
    multiple endocrine neoplasia 85.1 5 1351314 (1), 16472416 (1), 1971777 (1), 19606248 (1) (see all 5)
    hypercalcemia 81.1 170 17681097 (4), 16143533 (4), 2137363 (4), 11225473 (3) (see all 99)
    thyroid carcinoma, familial medullary 79.1 11 2112816 (1), 8099830 (1), 10474127 (1), 12437249 (1) (see all 11)
    bone loss 78.9 165 10100579 (4), 8461542 (4), 1933614 (4), 8992875 (4) (see all 99)
    thyroid nodule 69.6 33 18364376 (4), 9195818 (1), 15864423 (1), 19079272 (1) (see all 28)

    Genetic Association Database (GAD): CALCA
    Human Genome Epidemiology (HuGE) Navigator: CALCA (21 documents)

    Export disorders for CALCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALCA gene, integrated from 9 sources (see all 3211):
    (articles sorted by number of sources associating them with CALCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete sequence of human preprocalcitonin. (PubMed id 6546550)1, 2, 3 le Moullec J.-M.... Moukhtar M.S. (1984)
    2. BDNF and CGRP interaction: implications in migraine s usceptibility. (PubMed id 20959432)1, 4 Lemos C....Sousa A. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. (PubMed id 19736013)1, 4 MagaA+a J.J....Miranda-Duarte A. (2010)
    5. Frequencies of polymorphisms in cytokines, neurotrans mitters and adrenergic receptors in patients with complex regional pain syndrom e type I after distal radial fracture. (PubMed id 20173430)1, 4 Herlyn P....Gradl G. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. No association between CALCA polymorphisms and clinic al outcome or serum procalcitonin levels in German polytrauma patients. (PubMed id 19447044)1, 4 Hildebrand F....Stuhrmann M. (2009)
    8. BCL2-938C>A and CALCA-1786T>C polymorphisms in aseptic loosened total hip arthroplasty. (PubMed id 19541585)1, 4 Wedemeyer C....Bachmann H.S. (2009)
    9. Association of CALCA genetic polymorphism with essential hypertension. (PubMed id 18959118)1, 4 Luo X.L....Li Y.J. (2008)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 796 HGNC: 1437 AceView: CALCA Ensembl:ENSG00000110680 euGenes: HUgn796
    ECgene: CALCA H-InvDB: CALCA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALCA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/calca/
    Wikipedia http://en.wikipedia.org/wiki/Calcitonin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALCA gene:
    Search GeneIP for patents involving CALCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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