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CALCA Gene

protein-coding   GIFtS: 67
GCID: GC11M014945

Calcitonin-Related Polypeptide Alpha

(Previous name: calcitonin 1)
(Previous symbol: CALC1)
  See CALCA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcitonin-Related Polypeptide Alpha1 2     CGRP2
CALC11 2 3 5     CGRP12
Calcitonin 11 2     CT2
calcitonin1 2     KC2
Alpha-Type CGRP2 3     Calcitonin/Calcitonin-Related Polypeptide, Alpha2
Calcitonin Gene-Related Peptide I2 3     katacalcin2
CGRP-I2 3     

External Ids:    HGNC: 14371   Entrez Gene: 7962   Ensembl: ENSG000001106807   OMIM: 1141305   UniProtKB: P068813   
UniProtKB: P012583   

Export aliases for CALCA gene to outside databases

Previous GC identifers: GC11M016170 GC11M015736 GC11M015027 GC11M014952 GC11M014671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALCA Gene:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by
tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins.
Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related
peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants
encoding different isoforms have been found for this gene.(provided by RefSeq, Nov 2009)

GeneCards Summary for CALCA Gene:
CALCA (calcitonin-related polypeptide alpha) is a protein-coding gene. Diseases associated with CALCA include discitis, and reflex sympathetic dystrophy. GO annotations related to this gene include protein complex binding and identical protein binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by
promoting the incorporation of those ions in the bones
Function: Katacalcin is a potent plasma calcium-lowering peptide

Gene Wiki entry for CALCA (Calcitonin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCA gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCA promoter sequence
   Search Chromatin IP Primers for CALCA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

CALCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M014945:  view genomic region     (about GC identifiers)

Start:
14,988,214 bp from pter      End:
14,993,900 bp from pter
Size:
5,687 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881 (See protein sequence)
Recommended Name: Calcitonin gene-related peptide 1 precursor  
Size: 128 amino acids; 13898 Da
1 PDB 3D structure from and Proteopedia for CALCA:
1LS7 (3D)    
Secondary accessions: Q93048 Q9UCP0
Alternative splicing: 3 isoforms:  P06881-1   P01258-1   P01258-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

UniProtKB/Swiss-Prot: CALC_HUMAN, P01258 (See protein sequence)

Recommended Name: Calcitonin precursor  
Size: 141 amino acids; 15466 Da
1 PDB 3D structure from and Proteopedia for CALCA:
2JXZ (3D)    
Secondary accessions: B7ZL39 Q13935 Q13937 Q52LX7
Alternative splicing: 3 isoforms:  P01258-1   P01258-2   P06881-1   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CALCA: NX_P01258

Explore proteomics data for CALCA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr105, Thr109
  • Modification sites at PhosphoSitePlus

  • See CALCA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001029124.1  NP_001029125.1  NP_001732.1  

    ENSEMBL proteins: 
     ENSP00000417833   ENSP00000420618   ENSP00000331746   ENSP00000379657   ENSP00000354286  
     ENSP00000352663  
    Reactome Protein details: P06881 P01258

    CALCA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CALCA
    OriGene Protein Over-expression Lysate for CALCA
    OriGene MassSpec for CALCA
    OriGene Custom Protein Services for CALCA
    GenScript Custom Purified and Recombinant Proteins Services for CALCA
    Novus Biologicals CALCA Proteins
    Novus Biologicals CALCA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CALCA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CALCA 

     
    antibodies-online proteins for CALCA (28 products) 

     
    antibodies-online peptides for CALCA

    CALCA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALCA
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CALCA
    OriGene Custom Antibody Services for CALCA
    Novus Biologicals CALCA Antibodies
    Abcam antibodies for CALCA (P06881, P01258)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CALCA
    antibodies-online antibodies for CALCA (346 products) 

    CALCA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALCA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALCA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CALCA 
    antibodies-online kits for CALCA (102 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    Selected InterPro protein domains (see all 6):
     IPR021118 Calcitonin
     IPR018360 Calcitonin_CS
     IPR015476 Calcitonin_gene-rel_peptide
     IPR001693 Calcitonin_peptide-like
     IPR021116 Procalcitonin/adrenomedullin

    Graphical View of Domain Structure for InterPro Entry P06881
    Graphical View of Domain Structure for InterPro Entry P01258

    ProtoNet protein and cluster: P06881

    2 Blocks protein domains:
    IPB000443 Islet amyloid protein (amylin) signature
    IPB002163 Beta-type calcitonin signature


    UniProtKB/Swiss-Prot: CALCA_HUMAN, P06881
    Similarity: Belongs to the calcitonin family

    UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
    Similarity: Belongs to the calcitonin family


    Find genes that share domains with CALCA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALCA_HUMAN, P06881
    Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic
    vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also
    elevates platelet cAMP

         UniProtKB/Swiss-Prot: CALC_HUMAN, P01258
    Function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by
    promoting the incorporation of those ions in the bones
    Function: Katacalcin is a potent plasma calcium-lowering peptide

         Genatlas biochemistry entry for CALCA:
    calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same
    gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and
    PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine
    system,potent vasodilatator and hypotensor

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IDA16014619
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI17689535
    GO:0031716calcitonin receptor binding IPI8078488
    GO:0032403protein complex binding IDA14722252
         
    Find genes that share ontologies with CALCA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CALCA:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Calca):
     behavior/neurological  cardiovascular system  embryogenesis  hearing/vestibular/ear  homeostasis/metabolism 
     integument  mortality/aging  nervous system  normal  renal/urinary system 
     respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with CALCA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CALCA: Calcatm1Hku Calcatm1Rfg

       genOway: Develop your customized and physiologically relevant rodent model for CALCA

    miRNA
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    Block miRNA regulation of human, mouse, rat CALCA using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CALCA:
    hsa-miR-374b* hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCALCA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALCA
    Predesigned siRNA for gene silencing in human, mouse, rat CALCA

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for CALCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CALCA (NM_001033953)
    Sino Biological Human cDNA Clone for CALCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CALCA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCA

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10304) for CALCA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALCA_HUMAN, P06881: Secreted
    CALC_HUMAN, P01258: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    nucleus3
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    plasma membrane2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18057382
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CALCA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALCA About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    4RNA Polymerase I Promoter Opening
    Amyloids0.68
    5Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    Find genes that share SuperPaths with CALCA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CALCA
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALCA
        Myometrial Relaxation and Contraction Pathways
    Endothelin


    3 Reactome Pathways for CALCA
        Amyloids
    Calcitonin-like ligand receptors
    G alpha (s) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCA: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CALCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALCA (P068811, 2 P012581, 2, 3 ENSP000003317464) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCAP012581, 2EBI-1018474,EBI-1018474 MINT-8409770 MINT-8409885 MINT-8409840
    ATP2B2Q018141, 2, ENSP000003241724EBI-1018474,EBI-1174243 MINT-5204027 MINT-5203983 STRING: ENSP00000324172
    ATP2B4P236341, 2, ENSP000003503104EBI-1018474,EBI-1174388 MINT-5204003 MINT-5203983 STRING: ENSP00000350310
    CALCRLQ166021, ENSP000003761774EBI-962928,EBI-962878 STRING: ENSP00000376177
    ADCY1ENSP000002973234STRING: ENSP00000297323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001935endothelial cell proliferation IDA17267696
    GO:0001944vasculature development IDA17267696
    GO:0001976neurological system process involved in regulation of systemic arterial blood pressure IDA10642343
    GO:0001984vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA--
    GO:0002027regulation of heart rate IEA--

    Find genes that share ontologies with CALCA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for CALCA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    2 HMDB Compounds for CALCA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for CALCA gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 89.1 46 10711339 (4), 11755165 (2), 10988349 (2), 11804624 (2) (see all 25)
    alendronate 83.8 171 15032563 (10), 11695068 (6), 16523336 (6), 15607319 (6) (see all 99)
    vitamin d 83.1 261 15846740 (4), 10446876 (3), 12162505 (3), 2038639 (2) (see all 99)
    etidronate 83 112 9205627 (8), 15465502 (4), 8538482 (4), 8608360 (4) (see all 71)
    raloxifene 80.9 121 12708951 (3), 10943237 (3), 17376323 (3), 14557222 (3) (see all 99)
    risedronate 80.6 73 15032563 (11), 8592950 (5), 17227729 (2), 13680313 (2) (see all 49)
    calcium 80.6 1188 16014619 (9), 11695068 (6), 9440370 (6), 10707893 (6) (see all 99)
    calogen 80.2 14 9008693 (1), 15167766 (1), 9221486 (1), 2020925 (1) (see all 11)
    teriparatide 79.6 50 16709314 (7), 16421647 (5), 18413693 (3), 15167766 (1) (see all 33)
    elcatonin 76.9 42 10220278 (5), 7669941 (3), 8181470 (2), 17707708 (2) (see all 14)



    Find genes that share compounds with CALCA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALCA gene (3 alternative transcripts): 
    NM_001033952.2  NM_001033953.2  NM_001741.2  

    Unigene Cluster for CALCA:

    Calcitonin-related polypeptide alpha
    Hs.37058  [show with all ESTs]
    Unigene Representative Sequence: X02330
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486207 ENST00000494746(uc001mlv.1 uc001mlw.1) ENST00000469608
    ENST00000331587 ENST00000396372 ENST00000361010(uc001mlt.2 uc001mlu.2)
    ENST00000359642
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CALCA:
    hsa-miR-374b* hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCALCA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CALCA (NM_001033953)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCA
    Primer
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    OriGene qPCR primer pairs and template standards for CALCA
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CALCA
      QuantiTect SYBR Green Assays in human, mouse, rat CALCA
      QuantiFast Probe-based Assays in human, mouse, rat CALCA
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10304) for CALCA 

    Additional mRNA sequence: 

    BC069684.1 BC069704.1 BC069760.1 BC069778.1 BC093753.1 BC101599.1 BC143562.1 K03512.1 
    K03513.1 M26095.1 M64486.1 X00356.1 X02330.1 X03662.1 

    4 DOTS entries:

    DT.86840457  DT.100016988  DT.111153  DT.102824295 

    Selected AceView cDNA sequences (see all 43):

    AW296074 BX094781 BC069684 NM_001741 CD612756 M26095 AI695720 BF942171 
    BF447272 X03662 M64486 BC069704 X02330 BC069760 X00356 BC069778 
    BF942434 AA716058 CD612754 K03512 CB048118 CD612752 BF942024 BF942146 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CALCA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for CALCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALCA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATGCTGT
    CALCA Expression
    About this image


    CALCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Globus Pallidus
             Midbrain dopaminergic-like neurons
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Neuroendocrine Cells Trachea
             Alveolar type II cells
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Midbrain dopaminergic-like neurons
     
     Epithelial Cells
             Neuroendocrine Cells Stem Bronchi
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    CALCA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALCA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37058
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCA: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALCA
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCA
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CALCA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calca5 calcitonin/calcitonin-related polypeptide, alpha   --   7 (59.99 cM) 114631480 
    chicken
    (Gallus gallus)
    Aves CALCA6
    Gallus gallus calcitonin (CALCA), transcript varia...
    48(a)
    1 → many
    5(9980460-9984994) ENSGALG00000006054
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    1 → many
    1(64833205-64838856)
    zebrafish
    (Danio rerio)
    Actinopterygii calca6
    calcitonin/calcitonin-related polypeptide, alpha
    45(a)
    1 → many
    7(28806424-28811889) ENSDARG00000056590


    ENSEMBL Gene Tree for CALCA (if available)
    TreeFam Gene Tree for CALCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALCA gene
    CALCB2  
    2 SIMAP similar genes for CALCA using alignment to 2 protein entries:     CALCA_HUMAN (see all proteins):
    CALCB    IAPP

    Find genes that share paralogs with CALCA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CALCA
    PGOHUM00000242602


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALCA (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110234001,2
    C,F,A--14911058(+) GTGAAG/ATATGT 1 -- ds50018Minor allele frequency- A:0.21NA CSA WA EA 368
    rs1412818851,2
    --14911084(+) ACCTAC/TTGCTG 1 -- ds50010--------
    rs1818598501,2
    --14911127(+) AGAATA/GAAAAA 1 -- ds50010--------
    rs1451171341,2
    --14911217(+) AGGCTA/GAGGGG 1 -- ds50010--------
    rs734205901,2
    C,F--14911227(+) GTGCAT/AGAAGA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs110234011,2
    C,F,A--14911245(+) ATATGG/CAGGAA 1 -- ds500110Minor allele frequency- C:0.22NA CSA WA EA 549
    rs1863470001,2
    --14911264(+) ATGGGC/TAAAGG 1 -- ds50010--------
    rs118266911,2
    C,H--14911275(+) CAAACC/TTGCAT 1 -- ds50012Minor allele frequency- T:0.03NA 67
    rs1911004571,2
    --14911278(+) ACCTGA/CATGAA 1 -- ds50010--------
    rs1814725461,2
    --14911283(+) CATGAA/GGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CALCA (14988214 - 14993900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CALCA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897008CNV Loss21882294
    nsv832071CNV Loss17160897
    nsv897007CNV Gain21882294
    nsv897006CNV Gain21882294

    Human Gene Mutation Database (HGMD): CALCA
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CALCA
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114130    OMIM disorders: --

    Selected diseases for CALCA (see all 69):    
    About MalaCards
    discitis    reflex sympathetic dystrophy    cerebral arteriosclerosis    complex regional pain syndrome
    apudoma    duodenal endocrine tumor    paroxysmal hemicrania    sepsis in premature infants
    spinal stenosis    cluster headache    headache    tympanosclerosis
    wdha syndrome    multiple endocrine neoplasia type 2a    giant cell reparative granuloma    aneurysmal bone cysts
    familial medullary thyroid carcinoma    nodular goiter    osteoporosis, postmenopausal    idiopathic juvenile osteoporosis

    Selected diseases from the University of Copenhagen DISEASES database for CALCA (see all 28):
    Thyroid cancer     Osteoporosis     Migraine     Hypercalcemia
    Paget's disease of bone     Hyperparathyroidism     Carcinoma     Complex regional pain syndrome
    Goiter     Neuroendocrine tumor     Breast cancer     Hypoparathyroidism
    Autosomal dominant disease     Pain agnosia     Hypertension     Kidney failure
    Giant cell tumor     Arthritis     Phaeochromocytoma     Adenoma

    Find genes that share disorders with CALCA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CALCA gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 95.9 364 1595326 (7), 19726541 (7), 19606248 (5), 2112816 (4) (see all 99)
    osteoporosis 87.7 482 2035172 (7), 8837547 (6), 2188043 (4), 7917799 (4) (see all 99)
    carcinoma medullary 87 64 15779075 (4), 7716641 (2), 9021721 (2), 1350867 (2) (see all 52)
    osteoporosis postmenopausal 86.3 142 11810415 (3), 8154311 (3), 7748920 (3), 15293868 (3) (see all 99)
    men 2a 86 40 8094268 (3), 7638742 (3), 12437249 (2), 1677783 (2) (see all 28)
    multiple endocrine neoplasia 85.1 5 1351314 (1), 16472416 (1), 1971777 (1), 19606248 (1) (see all 5)
    hypercalcemia 81.1 170 17681097 (4), 16143533 (4), 2137363 (4), 11225473 (3) (see all 99)
    thyroid carcinoma, familial medullary 79.1 11 2112816 (1), 8099830 (1), 10474127 (1), 12437249 (1) (see all 11)
    bone loss 78.9 165 10100579 (4), 8461542 (4), 1933614 (4), 8992875 (4) (see all 99)
    thyroid nodule 69.6 33 18364376 (4), 9195818 (1), 15864423 (1), 19079272 (1) (see all 28)

    Genetic Association Database (GAD): CALCA
    Human Genome Epidemiology (HuGE) Navigator: CALCA (21 documents)

    Export disorders for CALCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALCA gene, integrated from 10 sources (see all 3225):
    (articles sorted by number of sources associating them with CALCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete sequence of human preprocalcitonin. (PubMed id 6546550)1, 2, 3 le Moullec J.-M.... Moukhtar M.S. (FEBS Lett. 1984)
    2. BDNF and CGRP interaction: implications in migraine susceptibility. (PubMed id 20959432)1, 4 Lemos C....Sousa A. (Cephalalgia 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. (PubMed id 19736013)1, 4 MagaA+a J.J....Miranda-Duarte A. (Knee 2010)
    5. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PubMed id 20173430)1, 4 Herlyn P....Gradl G. (Clin J Pain 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. No association between CALCA polymorphisms and clinical outcome or serum procalcitonin levels in German polytrauma patients. (PubMed id 19447044)1, 4 Hildebrand F....Stuhrmann M. (Cytokine 2009)
    8. BCL2-938C&gt;A and CALCA-1786T&gt;C polymorphisms in aseptic loosened total hip arthroplasty. (PubMed id 19541585)1, 4 Wedemeyer C....Bachmann H.S. (Eur. J. Med. Res. 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Association of CALCA genetic polymorphism with essential hypertension. (PubMed id 18959118)1, 4 Luo X.L....Li Y.J. (Chin. Med. J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 796 HGNC: 1437 AceView: CALCA Ensembl:ENSG00000110680 euGenes: HUgn796
    ECgene: CALCA H-InvDB: CALCA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALCA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/calca/
    Wikipedia http://en.wikipedia.org/wiki/Calcitonin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALCA gene:
    Search GeneIP for patents involving CALCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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