Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALB2 Gene

protein-coding   GIFtS: 60
GCID: GC16P071392

Calbindin 2

(Previous names: calbindin 2, 29kDa (calretinin))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calbindin 21 2     Calbindin 2, 29kDa (Calretinin)1
calretinin1 2     CAL22
29 KDa Calbindin2 3     Calbindin 2, (29kD, Calretinin)2
CAB292 3     Calbindin D29K2
CR2 3     

External Ids:    HGNC: 14351   Entrez Gene: 7942   Ensembl: ENSG000001721377   OMIM: 1140515   UniProtKB: P226763   
ORGUL members:         
NONCODE14:n408065      

Export aliases for CALB2 gene to outside databases

Previous GC identifers: GC16P062284 GC16P072115 GC16P071128 GC16P071168 GC16P069950 GC16P057160


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALB2 Gene:
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of
this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular
functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of
neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and
some cancers. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun 2010)

GeneCards Summary for CALB2 Gene: 
CALB2 (calbindin 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CALB2 include mixed germ cell-sex cord neoplasm, and cystadenofibroma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SCGN.

UniProtKB/Swiss-Prot: CALB2_HUMAN, P22676
Function: Calretinin is a calcium-binding protein which is abundant in auditory neurons

Gene Wiki entry for CALB2 (Calretinin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALB2 gene promoter:
         Max1   CREB   AML1a   MyoD   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   MIF-1   LyF-1   POU3F2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

CALB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P071392:  view genomic region     (about GC identifiers)

Start:
71,392,616 bp from pter      End:
71,424,341 bp from pter
Size:
31,726 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALB2_HUMAN, P22676 (See protein sequence)
Recommended Name: Calretinin  
Size: 271 amino acids; 31540 Da
Secondary accessions: A8K4Y1 Q53HD2 Q96BK4

Explore the universe of human proteins at neXtProt for CALB2: NX_P22676

Explore proteomics data for CALB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22676

  • CALB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001731.2  NP_009019.1  

    ENSEMBL proteins: 
     ENSP00000307508   ENSP00000454639   ENSP00000454467   ENSP00000340294  

    Human Recombinant Protein Products for CALB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALB2
    OriGene Protein Over-expression Lysate for CALB2
    OriGene MassSpec for CALB2 
    OriGene Custom Protein Services for CALB2
    GenScript Custom Purified and Recombinant Proteins Services for CALB2
    Novus Biologicals CALB2 Proteins
    Novus Biologicals CALB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CALB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005921gap junction IEA--

    CALB2 for ontologies           About GeneDecksing



    CALB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALB2
    R&D Systems Antibodies for CALB2 (Calretinin)
    OriGene Antibodies for CALB2
    OriGene Custom Antibody Services for CALB2
    GenScript Custom Superior Antibodies Services for CALB2
    Novus Biologicals CALB2 Antibodies
    Abcam antibodies for CALB2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CALB2
    LSBio Antibodies in human, mouse, rat for CALB2 

    Assay Products for CALB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P22676

    ProtoNet protein and cluster: P22676

    UniProtKB/Swiss-Prot: CALB2_HUMAN, P22676
    Similarity: Belongs to the calbindin family
    Similarity: Contains 6 EF-hand domains


    CALB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALB2_HUMAN, P22676
    Function: Calretinin is a calcium-binding protein which is abundant in auditory neurons

         Genatlas biochemistry entry for CALB2:
    calbindin (29kDa),vitamin D dependent calcium binding protein 2,from the intestine

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    CALB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALB2:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Calb2):
     behavior/neurological  nervous system  normal 

    CALB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calb2tm1Map for CALB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALB2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CALB2:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-9 hsa-miR-30b hsa-miR-3670 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCALB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALB2
    Sirion Biotech Customized adenovirus for overexpression of CALB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALB2 (see all 17)
    OriGene ORF clones in mouse, rat for CALB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALB2 (NM_007088)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALB2
    Sirion Biotech Customized lentivirus for stable overexpression of CALB2 
                         Customized lentivirus expression plasmids for stable overexpression of CALB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALB2
    Search LifeMap BioReagents cell lines for CALB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for CALB2 (P226763 ENSP000003075084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT1P042643, ENSP000002522444I2D: score=2 STRING: ENSP00000252244
    TUBA4AP683663, ENSP000002484374I2D: score=2 STRING: ENSP00000248437
    GRIN2BQ132243I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALB2

    1 HMDB Compound for CALB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/33 Novoseek inferred chemical compound relationships for CALB2 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 79.9 32 16188134 (4), 16415794 (3), 16056246 (3), 12883236 (3) (see all 19)
    co 115 73.8 3 8864572 (2), 9042211 (1)
    gaba 61.6 68 10996158 (3), 8646756 (3), 18361442 (2), 19492025 (2) (see all 31)
    choline 55.3 28 1721693 (2), 9423187 (1), 10495446 (1), 12692854 (1) (see all 24)
    calcium 49.2 171 9368033 (7), 18044987 (7), 11440160 (5), 10082975 (4) (see all 67)
    progesterone 46.4 25 15084844 (2), 12217766 (1), 15086841 (1), 15206556 (1) (see all 25)
    mucicarmine 45 3 11710688 (2), 15239680 (1)
    glutamate 43.1 28 10430473 (2), 10684887 (1), 17439984 (1), 10392842 (1) (see all 18)
    estrogen 41.7 25 17667535 (2), 15084844 (2), 12217766 (1), 15086841 (1) (see all 24)
    carbocyanine 40.8 1 16125175 (1)

    Search CenterWatch for drugs/clinical trials and news about CALB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALB2 gene (3 alternative transcripts): 
    NM_001740.4  NM_007088.3  NM_007087.2  

    Unigene Cluster for CALB2:

    Calbindin 2
    Hs.106857  [show with all ESTs]
    Unigene Representative Sequence: NM_001740
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302628(uc002faa.4 uc010vme.2) ENST00000562305 ENST00000490520
    ENST00000467817 ENST00000349553(uc002fac.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALB2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CALB2:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-9 hsa-miR-30b hsa-miR-3670 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidCALB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALB2
    Clone
    Products:
         
    OriGene clones in human, mouse for CALB2 (see all 17)
    OriGene ORF clones in mouse, rat for CALB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CALB2 (NM_007088)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALB2
    Sirion Biotech Customized lentivirus for stable overexpression of CALB2 
                         Customized lentivirus expression plasmids for stable overexpression of CALB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALB2
    OriGene qSTAR qPCR primer pairs in human, mouse for CALB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALB2

    Additional mRNA sequence: 

    AK222495.1 AK222648.1 AK291096.1 BC015484.2 NR_027910.2 X56667.1 

    6 DOTS entries:

    DT.310185  DT.100762092  DT.92421171  DT.92058224  DT.120660982  DT.92421172 

    24/88 AceView cDNA sequences (see all 88):

    F06729 BM696239 BM664668 BM761240 AI871063 BM795396 BQ935407 F02994 
    BM848443 T28148 BM784590 AI199351 BM708345 BM703170 BM664507 CB154546 
    BQ639244 F05058 BG747058 BG386726 AI417553 BC015484 BG706910 AW160769 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALB2 expression in normal human tissues (normalized intensities)      CALB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACCACCCA
    CALB2 Expression
    About this image


    CALB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 37 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Vomeronasal organ   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Cholinergic Amacrine Cells Ganglion Cell Layer
             Retina
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
             Human Ovarian Fibroblasts (HOF)   

    See CALB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALB2

    SOURCE GeneReport for Unigene cluster: Hs.106857

    UniProtKB/Swiss-Prot: CALB2_HUMAN, P22676
    Tissue specificity: Brain

        SABiosciences Expression via Pathway-Focused PCR Array including CALB2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALB2
    OriGene qSTAR qPCR primer pairs in human, mouse for CALB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CALB2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calb21 , 5 calbindin 21, 5 91.02(n)1
    98.52(a)1
      8 (57.44 cM)5
    123081  NM_007586.11  NP_031612.11 
     1101425395 
    chicken
    (Gallus gallus)
    Aves CALB21 calbindin 2, 29kDa (calretinin) 81.04(n)
    86.99(a)
      396255  NM_205316.1  NP_990647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059479.12   -- 78.2(n)   393691  BC059479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cbp53E3 calcium ion homeostasis calcium ion
    binding
    46(a)   53E4   --


    ENSEMBL Gene Tree for CALB2 (if available)
    TreeFam Gene Tree for CALB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALB2 gene
    SCGN2  CALB12  
    3 SIMAP similar genes for CALB2 using alignment to 4 protein entries:     CALB2_HUMAN (see all proteins):
    CALB1    SCGN    PLS1

    CALB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/842 SNPs in CALB2 are shown (see all 842)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862721581,2
    --71390656(+) TTAATC/TCTCAG 3 -- us2k10--------
    rs1396016631,2
    C--71390738(+) AGTGGC/TGCGAT 3 -- us2k10--------
    rs356624801,2
    C--71390872(+) TTTTT-/T/T   
       TTTTT
    AGTAG
    3 -- us2k11NA 2
    rs1497565841,2
    C--71390969(+) AGGATA/TACAGG 3 -- us2k10--------
    rs345440641,2
    C--71391024(+) CACATG/ACCCAT 3 -- us2k13Minor allele frequency- A:0.37NA EA 242
    rs1446761641,2
    --71391039(+) CAGAAA/GAGAAA 3 -- us2k10--------
    rs1146902381,2
    C,F--71391099(+) TTCTGG/CGATTC 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1180494461,2
    F--71391145(+) TAACCA/TCTGAG 3 -- us2k11Minor allele frequency- T:0.03EA 120
    rs99405071,2
    C,F,H--71391170(+) TAGGGG/ACTTTG 3 -- us2k1 tfbs326Minor allele frequency- A:0.08NS EA NA WA CSA 2352
    rs1903925201,2
    --71391196(+) AGGTGA/GATGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALB2 (71392616 - 71424341 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CALB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2640068CNV Insertion19546169
    nsv7285OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CALB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CALB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114051    OMIM disorders: --

    20/129 diseases for CALB2 (see all 129):    About MalaCards
    mixed germ cell-sex cord neoplasm    cystadenofibroma    ovarian serous cystadenofibroma    inverted follicular keratosis
    trisomy 22    ovarian fibrothecoma    heart cancer    steatocystoma multiplex
    malignant biphasic mesothelioma    monophasic synovial sarcoma    pericardial mesothelioma    pseudo-meigs syndrome
    sex cord-gonadal stromal tumor    pleomorphic liposarcoma    mixed epithelial stromal tumour    ovarian small cell carcinoma
    meigs syndrome    adenofibroma    tenosynovial giant cell tumor    sarcomatoid mesothelioma

    10 diseases from the University of Copenhagen DISEASES database for CALB2:
    Benign mesothelioma     Malignant mesothelioma     Sex cord-gonadal stromal tumor     Sertoli cell tumor
    Carcinoma     Malignant pleural mesothelioma     Malignant peritoneal mesothelioma     Adenofibroma
    Sertoli-Leydig cell tumor     Schizophrenia

    CALB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for CALB2 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mesothelioma 89 153 17916095 (5), 10896333 (5), 15188136 (5), 11299732 (4) (see all 63)
    malignant mesothelioma 87.9 35 14652817 (3), 8764740 (3), 14608532 (2), 17361207 (2) (see all 22)
    sex cord-stromal tumor 85.4 16 11603218 (2), 15256111 (2), 19550372 (2), 15626916 (1) (see all 12)
    sertoli-leydig cell tumor 84.1 8 15754297 (2), 11603218 (2), 12409724 (1), 19033865 (1) (see all 5)
    adenomatoid tumor 82.8 4 19543245 (2), 14608532 (1), 10414506 (1)
    epithelial mesothelioma 81.3 6 9796717 (2), 15093134 (1), 15064170 (1), 11381372 (1) (see all 5)
    sertoli cell tumor 80.4 6 17721194 (4), 19033865 (1)
    granulosa cell tumor 78.6 8 19115695 (2), 12409724 (1), 15381902 (1), 15754297 (1) (see all 6)
    pleural malignant mesothelioma 74.3 14 10697265 (2), 17279584 (2), 9796717 (2), 10595711 (1) (see all 11)
    thecoma 70.8 2 12409724 (1), 15754297 (1)

    Genetic Association Database (GAD): CALB2
    Human Genome Epidemiology (HuGE) Navigator: CALB2 (1 document)

    Export disorders for CALB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALB2 gene, integrated from 9 sources (see all 693):
    (articles sorted by number of sources associating them with CALB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. (PubMed id 18214032)1, 4, 9 Vonlanthen S....Schwaller B. (2007)
    2. Structure of the human brain calcium-binding protein calretinin and its expression in bacteria. (PubMed id 2001709)1, 2, 9 Parmentier M. and Lefort A. (1991)
    3. The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci. (PubMed id 1906795)1, 3, 9 Parmentier M....Mattei M.G. (1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human calbindins: cDNA and gene cloning. (PubMed id 2618861)1, 2 Parmentier M. (1989)
    6. Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDr. (PubMed id 10942575)1, 9 Marilley D. and Schwaller B. (2000)
    7. A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but no t in mesothelioma cells. (PubMed id 19998412)1, 9 HAoner K....Schwaller B. (2010)
    8. Calretinin and CD34 immunoreactivity of the endometrial stroma in normal endometrium and change of the immunoreactivity in dysfunctional uterine bleeding with evidence of 'disordered endometrial stroma'. (PubMed id 18604736)1, 9 Mai K.T....Veinot J.P. (2008)
    9. Calretinin immunohistochemistry: a simple and efficie nt tool to diagnose Hirschsprung disease. (PubMed id 19648883)1, 9 Guinard-Samuel V....Berrebi-Binczak D. (2009)
    10. Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. (PubMed id 18223328)1, 9 DeVilliers P....Wright T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 794 HGNC: 1435 AceView: CALB2 Ensembl:ENSG00000172137 euGenes: HUgn794
    ECgene: CALB2 H-InvDB: CALB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALB2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Calbindin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALB2 gene:
    Search GeneIP for patents involving CALB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CALB2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CALB2 (Calretinin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CALB2   OriGene RNAi products in human, mouse, rat for CALB2  
     OriGene qPCR primer pairs and template standards for CALB2   OriGene Protein Over-expression Lysate for CALB2  
     OriGene MassSpec something-or-other for CALB2   OriGene clones in human, mouse for CALB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CALB2   OriGene Purified Protein for CALB2  
     OriGene ORF clones in mouse, rat for CALB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CALB2   OriGene Custom Protein Services for CALB2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALB2
     QIAGEN SeqTarget long-range PCR primers for resequencing CALB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALB2
     GenScript Custom Purified and Recombinant Proteins Services for CALB2 GenScript cDNA clones with any tag delivered in your preferred vector for CALB2
     GenScript Custom Assay Services for CALB2 GenScript Custom Superior Antibodies Services for CALB2
     GenScript Custom overexpressing Cell Line Services for CALB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CALB2 promoter
     Search Chromatin IP Primers for CALB2
     RT2 qPCR Primer Assay in human, mouse, rat CALB2
     GNC Network for CALB2
     SABiosciences PCR Arrays including human, mouse, rat CALB2
     Search Tocris compounds for CALB2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CALB2 antibodies
     CALB2 proteins
     CALB2 lysates
     Antibodies for CALB2
     See all of Abcam's Antibodies, Kits and Proteins for CALB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CALB2




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CALB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALB2
     SwitchGear 3'UTR luciferase reporter plasmids for CALB2
     SwitchGear Promoter luciferase reporter plasmids for CALB2
     ThermoFisher Antibody for CALB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CALB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALB2
    Customized:
     lentivirus for stable overexpression of CALB2
     lentivirus expression plasmids for stable overexpression of CALB2
     adenovirus for overexpression of CALB2
     LSBio Antibodies in human, mouse, rat for CALB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CALB2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4