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Aliases for CALB2 Gene

Aliases for CALB2 Gene

  • Calbindin 2 2 3
  • 29 KDa Calbindin 3 4
  • Calretinin 2 3
  • CAB29 3 4
  • CR 3 4
  • Calbindin 2, 29kDa (Calretinin) 2
  • Calbindin 2, (29kD, Calretinin) 3
  • Calbindin D29K 3
  • CAL2 3

External Ids for CALB2 Gene

Previous GeneCards Identifiers for CALB2 Gene

  • GC16P062284
  • GC16P072115
  • GC16P071128
  • GC16P071168
  • GC16P069950
  • GC16P057160

Summaries for CALB2 Gene

Entrez Gene Summary for CALB2 Gene

  • This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for CALB2 Gene

CALB2 (Calbindin 2) is a Protein Coding gene. Diseases associated with CALB2 include trisomy 22 and sex cord-gonadal stromal tumor. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SCGN.

UniProtKB/Swiss-Prot for CALB2 Gene

  • Calretinin is a calcium-binding protein which is abundant in auditory neurons

Gene Wiki entry for CALB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALB2 Gene

Genomics for CALB2 Gene

Regulatory Elements for CALB2 Gene

Genomic Location for CALB2 Gene

71,358,713 bp from pter
71,390,438 bp from pter
31,726 bases
Plus strand

Genomic View for CALB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALB2 Gene

Proteins for CALB2 Gene

  • Protein details for CALB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K4Y1
    • Q53HD2
    • Q96BK4

    Protein attributes for CALB2 Gene

    271 amino acids
    Molecular mass:
    31540 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALB2 Gene

Proteomics data for CALB2 Gene at MOPED

Post-translational modifications for CALB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALB2 Gene

Antibody Products

No data available for DME Specific Peptides for CALB2 Gene

Domains for CALB2 Gene

Gene Families for CALB2 Gene

Protein Domains for CALB2 Gene

Suggested Antigen Peptide Sequences for CALB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EF-hand domains.
  • Belongs to the calbindin family.
  • Contains 6 EF-hand domains.
  • Belongs to the calbindin family.
genes like me logo Genes that share domains with CALB2: view

Function for CALB2 Gene

Molecular function for CALB2 Gene

GENATLAS Biochemistry:
calbindin (29kDa),vitamin D dependent calcium binding protein 2,from the intestine
UniProtKB/Swiss-Prot Function:
Calretinin is a calcium-binding protein which is abundant in auditory neurons

Gene Ontology (GO) - Molecular Function for CALB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CALB2: view

Phenotypes for CALB2 Gene

genes like me logo Genes that share phenotypes with CALB2: view

Animal Models for CALB2 Gene

MGI Knock Outs for CALB2:

miRNA for CALB2 Gene

miRTarBase miRNAs that target CALB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CALB2 Gene

Localization for CALB2 Gene

Subcellular locations from

Jensen Localization Image for CALB2 Gene COMPARTMENTS Subcellular localization image for CALB2 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CALB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005921 gap junction IEA --
genes like me logo Genes that share ontologies with CALB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CALB2 Gene

Pathways for CALB2 Gene

SuperPathways for CALB2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CALB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051480 cytosolic calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with CALB2: view

No data available for Pathways by source for CALB2 Gene

Drugs for CALB2 Gene

(1) HMDB Compounds for CALB2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(33) Novoseek inferred chemical compound relationships for CALB2 Gene

Compound -log(P) Hits PubMed IDs
b 723 79.9 31
co 115 73.8 3
gaba 61.6 38
choline 55.3 25
calcium 49.2 110
genes like me logo Genes that share compounds with CALB2: view

Transcripts for CALB2 Gene

Unigene Clusters for CALB2 Gene

Calbindin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALB2 Gene

No ASD Table

Relevant External Links for CALB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALB2 Gene

mRNA expression in normal human tissues for CALB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALB2 Gene

This gene is overexpressed in Brain - Hypothalamus (11.9), Adipose - Visceral (Omentum) (4.4), Brain - Cerebellum (4.3), and Brain - Cerebellar Hemisphere (4.2).

Protein differential expression in normal tissues for CALB2 Gene

This gene is overexpressed in Testis (29.9), Nasopharynx (10.2), and Fetal testis (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALB2 Gene

SOURCE GeneReport for Unigene cluster for CALB2 Gene Hs.106857

mRNA Expression by UniProt/SwissProt for CALB2 Gene

Tissue specificity: Brain
genes like me logo Genes that share expressions with CALB2: view

Primer Products

In Situ Assay Products

No data available for Expression partners for CALB2 Gene

Orthologs for CALB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CALB2 35
  • 91.39 (n)
  • 96.68 (a)
CALB2 36
  • 97 (a)
(Canis familiaris)
Mammalia CALB2 35
  • 93.68 (n)
  • 98.42 (a)
CALB2 36
  • 90 (a)
(Mus musculus)
Mammalia Calb2 35
  • 91.02 (n)
  • 98.52 (a)
Calb2 16
Calb2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Calb2 35
  • 91.14 (n)
  • 98.89 (a)
(Monodelphis domestica)
Mammalia CALB2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CALB2 36
  • 93 (a)
(Pan troglodytes)
Mammalia CALB2 36
  • 99 (a)
(Gallus gallus)
Aves CALB2 35
  • 81.04 (n)
  • 86.99 (a)
CALB2 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia calb2 35
  • 72.68 (n)
  • 79.32 (a)
(Danio rerio)
Actinopterygii -- 35
calb2a 35
  • 73.36 (n)
  • 77.32 (a)
calb2a 36
  • 76 (a)
calb2b 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.698 35
fruit fly
(Drosophila melanogaster)
Insecta Cbp53E 37
  • 46 (a)
Cbp53E 36
  • 41 (a)
Species with no ortholog for CALB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALB2 Gene

Gene Tree for CALB2 (if available)
Gene Tree for CALB2 (if available)

Paralogs for CALB2 Gene

Paralogs for CALB2 Gene

(3) SIMAP similar genes for CALB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALB2: view

Variants for CALB2 Gene

Sequence variations from dbSNP and Humsavar for CALB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs746732 -- 71,366,858(+) gttat(G/T)cccat intron-variant
rs889704 -- 71,358,159(-) GTCTT(G/T)CAGAG upstream-variant-2KB
rs1800642 -- 71,371,881(+) AGATT(C/T)GGAAG intron-variant
rs1862818 -- 71,357,965(-) GGGGG(A/G)CTTTT upstream-variant-2KB
rs2004142 -- 71,366,630(+) ctggc(C/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALB2 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv2640068 CNV Insertion 19546169

Relevant External Links for CALB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALB2 Gene

Disorders for CALB2 Gene

(98) Novoseek inferred disease relationships for CALB2 Gene

Disease -log(P) Hits PubMed IDs
mesothelioma 89 131
malignant mesothelioma 87.9 29
sex cord-stromal tumor 85.4 15
sertoli-leydig cell tumor 84.1 7
adenomatoid tumor 82.8 4

Relevant External Links for CALB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CALB2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CALB2 Gene

Publications for CALB2 Gene

  1. The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci. (PMID: 1906795) Parmentier M. … Mattei M.G. (Cytogenet. Cell Genet. 1991) 2 3 23
  2. Structure of the human brain calcium-binding protein calretinin and its expression in bacteria. (PMID: 2001709) Parmentier M. … Lefort A. (Eur. J. Biochem. 1991) 3 4 23
  3. Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. (PMID: 18214032) Vonlanthen S. … Schwaller B. (Anticancer Res. 2007) 3 23 48
  4. Calretinin expression in hilar mossy cells of the hippocampal dentate gyrus of nonhuman primates and humans. (PMID: 18189312) Seress L. … LAcrA!nth C. (Hippocampus 2008) 3 23
  5. Alternative splicing of calretinin mRNA leads to different forms of calretinin. (PMID: 7607211) Schwaller B. … Hunziker W. (Eur. J. Biochem. 1995) 3 23

Products for CALB2 Gene

Sources for CALB2 Gene

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