CALB2 Gene

Aliases
for CALB2 gene

Previous GC identifers: GC16P062284 GC16P072115 GC16P071128 GC16P071168 GC16P069950 GC16P057160

Summaries
for CALB2 gene

Genomic Views
for CALB2 gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010498.15  

SwitchGear Promoter luciferase reporter plasmid: CALB2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALB2

CALB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P071392:  view genomic region     (about GC identifiers)

Proteins
for CALB2 gene

Explore the universe of human proteins at neXtProt for CALB2: NX_P22676

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CALB2 OriGene Protein Over-expression Lysate: CALB2 OriGene Custom Protein Services for CALB2
	GenScript Custom Purified and Recombinant Proteins Services for CALB2
	Novus Biologicals CALB2 Proteins Novus Biologicals CALB2 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CALB2
	Uscn Proteins for CALB2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CALB2
	R&D Systems Antibodies for CALB2 (Calretinin)
	OriGene Antibodies (see all 6): CALB2 OriGene Custom Antibody Services for CALB2
	GenScript Custom Superior Antibodies Services for CALB2
	Novus Biologicals CALB2 Antibodies
	Abcam antibodies for CALB2
	Uscn Antibodies for CALB2
	ThermoFisher Antibody for CALB2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALB2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALB2

Protein Domains /
Families
for CALB2 gene

ProtoNet protein and cluster: P22676

Function
for CALB2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CALB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALB2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CALB2:
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-9 hsa-miR-30b hsa-miR-3670 hsa-miR-30e
		SwitchGear 3'UTR luciferase reporter plasmid: CALB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALB2 (see all 7) OriGene shRNA RFP: CALB2 OriGene siRNA: CALB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALB2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CALB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALB2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALB2 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CALB2 (NM_007088)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALB2
		Search LifeMap BioReagents cell lines for CALB2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALB2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Calb2)

Pathways & Interactions
for CALB2 gene

Drugs & Compounds
for CALB2 gene

Transcripts
for CALB2 gene

Expression
for CALB2 gene

CALB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCACCCA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeGanglion Cell LayerCholinergic Amacrine Cells			Amacrine, Retina
	EyeInner Nuclear LayerCholinergic Amacrine Cells			Amacrine, Retina
	EyeInner Nuclear LayerAII Amacrine Cells			Amacrine, Retina
	OvaryAntral FollicleCumulus Cells			Ovary
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Retinal cells (Generation of retina...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALB2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALB2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALB2

Orthologs
for CALB2 gene

Paralogs
for CALB2 gene

Paralogs for CALB2 gene

SCGN²  CALB1²  

3 SIMAP similar genes for CALB2 using alignment to 4 protein entries:     CALB2_HUMAN (see all proteins):

CALB1    SCGN    PLS1

CALB2 for paralogs           About GeneDecksing

Genomic Variants
for CALB2 gene

10/639 NCBI SNPs in CALB2 are shown (see all 639)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1862721581,2		--	71390656(+)	TTAATC/TCTCAG	3	--	us2k1		0	--	--	--	--
rs1396016631,2		--	71390738(+)	AGTGGC/TGCGAT	3	--	us2k1		0	--	--	--	--
rs1497565841,2		--	71390969(+)	AGGATA/TACAGG	3	--	us2k1		0	--	--	--	--
rs345440641,2	C,	--	71391024(+)	CACATG/ACCCAT	3	--	us2k1		3		NA EA	242
rs1446761641,2		--	71391039(+)	CAGAAA/GAGAAA	3	--	us2k1		0	--	--	--	--
rs1146902381,2	F,	--	71391099(+)	TTCTGG/CGATTC	3	--	us2k1		1		WA	118
rs1180494461,2	F,	--	71391145(+)	TAACCA/TCTGAG	3	--	us2k1		1		EA	120
rs99405071,2	C,F,H,	--	71391170(+)	TAGGGG/ACTTTG	3	--	us2k1 tfbs3		26		NS EA NA WA CSA	2352
rs1903925201,2		--	71391196(+)	AGGTGA/GATGGG	3	--	us2k1		0	--	--	--	--
rs1829460911,2		--	71391206(+)	GTACCC/TCTAAA	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALB2 (71392616 - 71424341 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CALB2
     1 Indel: 102325

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALB2

DNA2.0 Custom Variant and Variant Library Synthesis for CALB2

Disorders / Diseases
for CALB2 gene

20/135 diseases for CALB2

10/98 Novoseek disease relationships for CALB2 gene (see all 98)    About this table

Publications
for CALB2 gene

PubMed articles for CALB2 gene, integrated from 9 sources (see all 692): (articles sorted by number of sources associating them with CALB2)

Utopia: connect your pdf to the dynamic world of online information

1. Structure of the human brain calcium-binding protein calretinin and its expression in bacteria. (PubMed id 2001709)^{1, 2, 9} Parmentier M. and Lefort A. (1991)
2. The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci. (PubMed id 1906795)^{1, 3, 9} Parmentier M....Mattei M.G. (1991)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. The human calbindins: cDNA and gene cloning. (PubMed id 2618861)^{1, 2} Parmentier M. (1989)
5. Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDr. (PubMed id 10942575)^{1, 9} Marilley D. and Schwaller B. (2000)
6. A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but no t in mesothelioma cells. (PubMed id 19998412)^{1, 9} HAoner K....Schwaller B. (2010)
7. Calretinin and CD34 immunoreactivity of the endometrial stroma in normal endometrium and change of the immunoreactivity in dysfunctional uterine bleeding with evidence of 'disordered endometrial stroma'. (PubMed id 18604736)^{1, 9} Mai K.T....Veinot J.P. (2008)
8. Calretinin immunohistochemistry: a simple and efficie nt tool to diagnose Hirschsprung disease. (PubMed id 19648883)^{1, 9} Guinard-Samuel V....Berrebi-Binczak D. (2009)
9. Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. (PubMed id 18223328)^{1, 9} DeVilliers P....Wright T. (2008)
10. Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. (PubMed id 18214032)^{1, 9} Vonlanthen S....Schwaller B. (2007)

External Searches for CALB2 gene

Genome Databases showing CALB2 gene

Other Databases showing CALB2 gene

Specialized Databases showing CALB2 gene

Products
for CALB2 gene