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Aliases for CAGE1 Gene

Aliases for CAGE1 Gene

  • Cancer Antigen 1 2 3 5
  • Cancer/Testis Antigen 3 2 3 4
  • Cancer/Testis Antigen 95 2 3
  • CTAG3 3 4
  • CT3 3 4
  • Cancer/Testis Antigen Gene 1 3
  • BA69L16.7 3
  • CAGE-1 4
  • CT95 3

External Ids for CAGE1 Gene

Previous HGNC Symbols for CAGE1 Gene

  • CTAG3

Previous GeneCards Identifiers for CAGE1 Gene

  • GC06M007312
  • GC06M007273

Summaries for CAGE1 Gene

GeneCards Summary for CAGE1 Gene

CAGE1 (Cancer Antigen 1) is a Protein Coding gene. Diseases associated with CAGE1 include rectal neoplasm and chronic frontal sinusitis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAGE1 Gene

Genomics for CAGE1 Gene

Regulatory Elements for CAGE1 Gene

Promoters for CAGE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAGE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAGE1 Gene

Chromosome:
6
Start:
7,326,654 bp from pter
End:
7,389,743 bp from pter
Size:
63,090 bases
Orientation:
Minus strand

Genomic View for CAGE1 Gene

Genes around CAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAGE1 Gene

Proteins for CAGE1 Gene

  • Protein details for CAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC20-CAGE1_HUMAN
    Recommended name:
    Cancer-associated gene 1 protein
    Protein Accession:
    Q8TC20
    Secondary Accessions:
    • D6RCT9
    • Q5TAM0
    • Q86TM4
    • Q8N7R5

    Protein attributes for CAGE1 Gene

    Size:
    777 amino acids
    Molecular mass:
    90250 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16451.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CAGE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAGE1 Gene

Proteomics data for CAGE1 Gene at MOPED

Post-translational modifications for CAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAGE1 Gene

Domains & Families for CAGE1 Gene

Protein Domains for CAGE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAGE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CAGE1 Gene

Function for CAGE1 Gene

Phenotypes for CAGE1 Gene

genes like me logo Genes that share phenotypes with CAGE1: view

Animal Model Products

miRNA for CAGE1 Gene

miRTarBase miRNAs that target CAGE1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAGE1 Gene

Localization for CAGE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAGE1 Gene COMPARTMENTS Subcellular localization image for CAGE1 gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CAGE1 Gene

Pathways & Interactions for CAGE1 Gene

SuperPathways for CAGE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAGE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CAGE1 Gene

Drugs & Compounds for CAGE1 Gene

No Compound Related Data Available

Transcripts for CAGE1 Gene

mRNA/cDNA for CAGE1 Gene

Unigene Clusters for CAGE1 Gene

Cancer antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAGE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - - -

Relevant External Links for CAGE1 Gene

GeneLoc Exon Structure for
CAGE1
ECgene alternative splicing isoforms for
CAGE1

Expression for CAGE1 Gene

mRNA expression in normal human tissues for CAGE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAGE1 Gene

This gene is overexpressed in Testis (x49.4).

Protein differential expression in normal tissues from HIPED for CAGE1 Gene

This gene is overexpressed in Islet of Langerhans (43.6) and Urine (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAGE1 Gene



SOURCE GeneReport for Unigene cluster for CAGE1 Gene Hs.721486

mRNA Expression by UniProt/SwissProt for CAGE1 Gene

Q8TC20-CAGE1_HUMAN
Tissue specificity: Testis-specific expression in normal tissues, but wide expression among cancer tissues and cell lines.
genes like me logo Genes that share expression patterns with CAGE1: view

Protein tissue co-expression partners for CAGE1 Gene

Primer Products

In Situ Assay Products

Orthologs for CAGE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAGE1 35
  • 80.26 (n)
  • 66.23 (a)
CAGE1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAGE1 35
  • 77.2 (n)
  • 64.04 (a)
CAGE1 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cage1 35
  • 73.15 (n)
  • 60.35 (a)
Cage1 16
Cage1 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAGE1 35
  • 99.44 (n)
  • 99.05 (a)
CAGE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cage1 35
  • 72.5 (n)
  • 58.56 (a)
oppossum
(Monodelphis domestica)
Mammalia CAGE1 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAGE1 36
  • 39 (a)
OneToOne
Species with no ortholog for CAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAGE1 Gene

ENSEMBL:
Gene Tree for CAGE1 (if available)
TreeFam:
Gene Tree for CAGE1 (if available)

Paralogs for CAGE1 Gene

No data available for Paralogs for CAGE1 Gene

Variants for CAGE1 Gene

Sequence variations from dbSNP and Humsavar for CAGE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10223538 - 7,378,798(+) CACTA(A/G)TTTCC reference, missense
rs2876098 - 7,373,974(+) AGTTC(G/T)CCCGA reference, missense
rs754699 -- 7,361,499(-) ACTTA(C/T)ATGCA intron-variant
rs942664 -- 7,328,920(-) ATATA(C/T)ACACA intron-variant, downstream-variant-500B
rs879294 -- 7,341,603(+) GTCCA(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195
nsv883433 CNV Gain 21882294

Variation tolerance for CAGE1 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAGE1 Gene

HapMap Linkage Disequilibrium report
CAGE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAGE1 Gene

Disorders for CAGE1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CAGE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectal neoplasm
  • neoplasm of rectum
chronic frontal sinusitis
prostate lymphoma
  • lymphoma of prostate
gastric adenosquamous carcinoma
  • adenosquamous carcinoma of stomach
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search CAGE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAGE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAGE1
genes like me logo Genes that share disorders with CAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAGE1 Gene

Publications for CAGE1 Gene

  1. Identification and characterization of a novel cancer/testis antigen gene CAGE-1. (PMID: 12531476) Park S. … Jeoung D.I. (Biochim. Biophys. Acta 2003) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs. (PMID: 24174534) Kim Y. … Jeoung D. (J. Biol. Chem. 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance. (PMID: 20374034) Yiu C.C. … Chow L.W. (Expert Opin Investig Drugs 2010) 23

Products for CAGE1 Gene

Sources for CAGE1 Gene

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