Aliases for CADPS2 Gene
External Ids for CADPS2 Gene
Previous GeneCards Identifiers for CADPS2 Gene
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
GeneCards Summary for CADPS2 Gene
CADPS2 (Calcium Dependent Secretion Activator 2) is a Protein Coding gene. Diseases associated with CADPS2 include Cyclothymic Disorder and Persistent Hyperplastic Primary Vitreous. GO annotations related to this gene include lipid binding. An important paralog of this gene is CADPS.
UniProtKB/Swiss-Prot for CADPS2 Gene
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).