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Aliases for CADPS2 Gene

Aliases for CADPS2 Gene

  • Ca++-Dependent Secretion Activator 2 2 3
  • Calcium-Dependent Activator Protein For Secretion 2 3 4
  • KIAA1591 4 6
  • CAPS-2 3 4
  • Ca++-Dependent Activator Protein For Secretion 2 2
  • Ca2+-Dependent Activator Protein For Secretion 2 3
  • Calcium-Dependent Secretion Activator 2 3
  • CAPS2 4

External Ids for CADPS2 Gene

Summaries for CADPS2 Gene

Entrez Gene Summary for CADPS2 Gene

  • This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for CADPS2 Gene

CADPS2 (Ca++-Dependent Secretion Activator 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CADPS.

UniProtKB/Swiss-Prot for CADPS2 Gene

  • Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

Gene Wiki entry for CADPS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADPS2 Gene

Genomics for CADPS2 Gene

Genomic Location for CADPS2 Gene

Start:
122,318,424 bp from pter
End:
122,886,759 bp from pter
Size:
568,336 bases
Orientation:
Minus strand

Genomic View for CADPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CADPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADPS2 Gene

Regulatory Elements for CADPS2 Gene

Proteins for CADPS2 Gene

  • Protein details for CADPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW7-CAPS2_HUMAN
    Recommended name:
    Calcium-dependent secretion activator 2
    Protein Accession:
    Q86UW7
    Secondary Accessions:
    • A4D0X3
    • B7ZM56
    • Q658Q2
    • Q7Z5T7
    • Q8IZW9
    • Q8N7M4
    • Q9H6P4
    • Q9HCI1
    • Q9NWK8

    Protein attributes for CADPS2 Gene

    Size:
    1296 amino acids
    Molecular mass:
    147735 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with the dopamine receptor DRD2.
    SequenceCaution:
    • Sequence=AAH54339.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AK098170; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305}; Sequence=BAA91372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15210.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CADPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADPS2 Gene

Proteomics data for CADPS2 Gene at MOPED

Post-translational modifications for CADPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CADPS2 Gene

Domains for CADPS2 Gene

Gene Families for CADPS2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for CADPS2 Gene

UniProtKB/Swiss-Prot:

CAPS2_HUMAN
Domain:
  • The PH domain is essential for regulated exocytosis and binds phospholipids.:
    • Q86UW7
  • Contains 1 C2 domain.:
    • Q86UW7
  • Contains 1 MHD1 (MUNC13 homology domain 1) domain.:
    • Q86UW7
  • Contains 1 PH domain.:
    • Q86UW7
genes like me logo Genes that share domains with CADPS2: view

Function for CADPS2 Gene

Molecular function for CADPS2 Gene

UniProtKB/Swiss-Prot Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

Gene Ontology (GO) - Molecular Function for CADPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008289 lipid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CADPS2: view
genes like me logo Genes that share phenotypes with CADPS2: view

Animal Models for CADPS2 Gene

MGI Knock Outs for CADPS2:

miRNA for CADPS2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CADPS2 Gene

Localization for CADPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADPS2 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADPS2 Gene COMPARTMENTS Subcellular localization image for CADPS2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CADPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic membrane-bounded vesicle --
GO:0030054 cell junction IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
GO:0042734 presynaptic membrane IEA --
genes like me logo Genes that share ontologies with CADPS2: view

Pathways for CADPS2 Gene

SuperPathways for CADPS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CADPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009267 cellular response to starvation IEA --
GO:0015031 protein transport IEA --
GO:0016082 synaptic vesicle priming IEA --
GO:0045921 positive regulation of exocytosis IEA --
genes like me logo Genes that share ontologies with CADPS2: view

No data available for Pathways by source for CADPS2 Gene

Compounds for CADPS2 Gene

(2) HMDB Compounds for CADPS2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7
genes like me logo Genes that share compounds with CADPS2: view

Transcripts for CADPS2 Gene

Unigene Clusters for CADPS2 Gene

Ca++-dependent secretion activator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CADPS2 Gene

No ASD Table

Relevant External Links for CADPS2 Gene

GeneLoc Exon Structure for
CADPS2
ECgene alternative splicing isoforms for
CADPS2

Expression for CADPS2 Gene

mRNA expression in normal human tissues for CADPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADPS2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.6) and Brain - Cerebellum (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CADPS2 Gene

SOURCE GeneReport for Unigene cluster for CADPS2 Gene Hs.649459

mRNA Expression by UniProt/SwissProt for CADPS2 Gene

Q86UW7-CAPS2_HUMAN
Tissue specificity: Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.
genes like me logo Genes that share expressions with CADPS2: view

Orthologs for CADPS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CADPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADPS2 36
  • 99.59 (n)
  • 99.69 (a)
CADPS2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CADPS2 36
  • 92.3 (n)
  • 96.97 (a)
CADPS2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CADPS2 36
  • 90.17 (n)
  • 96.5 (a)
CADPS2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadps2 36
  • 90.13 (n)
  • 96.22 (a)
Cadps2 16
Cadps2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CADPS2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CADPS2 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadps2 36
  • 89.87 (n)
  • 96.38 (a)
chicken
(Gallus gallus)
Aves CADPS2 36
  • 84.11 (n)
  • 91.23 (a)
CADPS2 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CADPS2 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cadps2 36
  • 76.83 (n)
  • 83.24 (a)
Str.19227 36
zebrafish
(Danio rerio)
Actinopterygii cadps2 36
cadps2 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Caps 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-31 37
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
Species with no ortholog for CADPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CADPS2 Gene

ENSEMBL:
Gene Tree for CADPS2 (if available)
TreeFam:
Gene Tree for CADPS2 (if available)

Paralogs for CADPS2 Gene

Paralogs for CADPS2 Gene

Selected SIMAP similar genes for CADPS2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CADPS2: view

Variants for CADPS2 Gene

Sequence variations from dbSNP and Humsavar for CADPS2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1686 -- 122,729,799(+) TTGCA(C/T)CAACA intron-variant
rs16458 -- 122,511,273(+) TACAA(-/TTCC)ATTCC intron-variant
rs37888 -- 122,804,099(-) ACCAG(A/T)GATAA intron-variant
rs37889 -- 122,804,082(-) AGTGT(A/G)GTAGC intron-variant
rs37890 -- 122,803,994(-) GTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADPS2 Gene

Variant ID Type Subtype PubMed ID
nsv5931 CNV Loss 18451855
esv269458 CNV Insertion 20981092
esv274307 CNV Insertion 20981092
esv2676994 CNV Deletion 23128226
esv271903 CNV Insertion 20981092
esv272058 CNV Insertion 20981092
esv272553 CNV Insertion 20981092
nsv824293 CNV Loss 20364138
nsv524192 CNV Gain 19592680
esv2069189 CNV Deletion 18987734
esv2658553 CNV Deletion 23128226
esv1407742 CNV Deletion 17803354

Relevant External Links for CADPS2 Gene

HapMap Linkage Disequilibrium report
CADPS2
Human Gene Mutation Database (HGMD)
CADPS2

Disorders for CADPS2 Gene

(1) University of Copenhagen DISEASES for CADPS2 Gene

(1) Novoseek inferred disease relationships for CADPS2 Gene

Disease -log(P) Hits PubMed IDs
autistic 73.1 5

Relevant External Links for CADPS2

Genetic Association Database (GAD)
CADPS2
Human Genome Epidemiology (HuGE) Navigator
CADPS2
genes like me logo Genes that share disorders with CADPS2: view

No data available for UniProtKB/Swiss-Prot for CADPS2 Gene

Publications for CADPS2 Gene

  1. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. (PMID: 12659812) Cisternas F.A. … Ray P.N. (Genomics 2003) 3 4 23
  2. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. (PMID: 14530279) Speidel D. … Reim K. (J. Biol. Chem. 2003) 3 4 23
  3. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. (PMID: 17380209) Sadakata T. … Furuichi T. (J. Clin. Invest. 2007) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CADPS2 Gene

Sources for CADPS2 Gene

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