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Aliases for CADPS Gene

Aliases for CADPS Gene

  • Ca++-Dependent Secretion Activator 2 3
  • Calcium-Dependent Activator Protein For Secretion 1 3 4
  • CAPS-1 3 4
  • CAPS1 3 4
  • CAPS 3 4
  • Ca2+-Dependent Activator Protein For Secretion 3
  • Ca2+-Regulated Cytoskeletal Protein 3
  • Ca2+-Dependent Secretion Activator 3
  • KIAA1121 4
  • CADPS1 3

External Ids for CADPS Gene

Previous GeneCards Identifiers for CADPS Gene

  • GC03M061249
  • GC03M061786
  • GC03M062238
  • GC03M062341
  • GC03M062359

Summaries for CADPS Gene

Entrez Gene Summary for CADPS Gene

  • This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

GeneCards Summary for CADPS Gene

CADPS (Ca++-Dependent Secretion Activator) is a Protein Coding gene. Diseases associated with CADPS include pineal gland cancer and pineoblastoma. GO annotations related to this gene include protein kinase binding and lipid binding. An important paralog of this gene is CADPS2.

UniProtKB/Swiss-Prot for CADPS Gene

  • Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

Gene Wiki entry for CADPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADPS Gene

Genomics for CADPS Gene

Regulatory Elements for CADPS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CADPS Gene

Chromosome:
3
Start:
62,398,346 bp from pter
End:
62,875,389 bp from pter
Size:
477,044 bases
Orientation:
Minus strand

Genomic View for CADPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CADPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADPS Gene

Proteins for CADPS Gene

  • Protein details for CADPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULU8-CAPS1_HUMAN
    Recommended name:
    Calcium-dependent secretion activator 1
    Protein Accession:
    Q9ULU8
    Secondary Accessions:
    • A6NF60
    • Q13339
    • Q6GQQ6
    • Q8N2Z5
    • Q8N3M7
    • Q8NFR0
    • Q96BC2

    Protein attributes for CADPS Gene

    Size:
    1353 amino acids
    Molecular mass:
    152786 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with RASL10B (By similarity). Interacts with the dopamine receptor DRD2.
    SequenceCaution:
    • Sequence=AAA79701.1; Type=Frameshift; Positions=1305, 1317; Evidence={ECO:0000305}; Sequence=AAH15754.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86435.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADPS Gene

    Alternative splice isoforms for CADPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADPS Gene

Proteomics data for CADPS Gene at MOPED

Post-translational modifications for CADPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CADPS Gene

Domains & Families for CADPS Gene

Gene Families for CADPS Gene

Protein Domains for CADPS Gene

Suggested Antigen Peptide Sequences for CADPS Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULU8

UniProtKB/Swiss-Prot:

CAPS1_HUMAN :
  • The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).
Domain:
  • The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).
  • Contains 1 C2 domain.
  • Contains 1 MHD1 (MUNC13 homology domain 1) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with CADPS: view

Function for CADPS Gene

Molecular function for CADPS Gene

GENATLAS Biochemistry:
ca2+ dependent activator protein for secretion,neural/endocrine specific cytosolic and peripheral membrane protein required for the exocytosis of secretory vesicles,phopholipid protein,specifically interacting with phosphotidylinositol 4,5 biphosphate
UniProtKB/Swiss-Prot Function:
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

Gene Ontology (GO) - Molecular Function for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17984325
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CADPS: view
genes like me logo Genes that share phenotypes with CADPS: view

Animal Models for CADPS Gene

MGI Knock Outs for CADPS:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CADPS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CADPS Gene

Localization for CADPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADPS Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADPS Gene COMPARTMENTS Subcellular localization image for CADPS gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 1516133
GO:0030054 cell junction IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CADPS: view

Pathways & Interactions for CADPS Gene

SuperPathways for CADPS Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis TAS 1516133
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IEA --
GO:0016082 synaptic vesicle priming IEA --
GO:0050432 catecholamine secretion IEA --
genes like me logo Genes that share ontologies with CADPS: view

No data available for Pathways by source and SIGNOR curated interactions for CADPS Gene

Drugs & Compounds for CADPS Gene

(5) Drugs for CADPS Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Nifedipine Approved Pharma Activator 104
Norepinephrine Approved Pharma 206
Calcium Nutra 0
ATP Pharma Activator 0
genes like me logo Genes that share compounds with CADPS: view

Transcripts for CADPS Gene

Unigene Clusters for CADPS Gene

Ca++-dependent secretion activator:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CADPS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADPS Gene

No ASD Table

Relevant External Links for CADPS Gene

GeneLoc Exon Structure for
CADPS
ECgene alternative splicing isoforms for
CADPS

Expression for CADPS Gene

mRNA expression in normal human tissues for CADPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADPS Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.2), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cortex (x4.2), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for CADPS Gene

This gene is overexpressed in Brain (22.3), Frontal cortex (22.3), Retina (10.1), and Fetal Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CADPS Gene



SOURCE GeneReport for Unigene cluster for CADPS Gene Hs.654933

mRNA Expression by UniProt/SwissProt for CADPS Gene

Q9ULU8-CAPS1_HUMAN
Tissue specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.
genes like me logo Genes that share expression patterns with CADPS: view

Protein tissue co-expression partners for CADPS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CADPS Gene

This gene was present in the common ancestor of animals.

Orthologs for CADPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CADPS 35
  • 93.34 (n)
  • 98.14 (a)
CADPS 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CADPS 35
  • 93.56 (n)
  • 97.47 (a)
CADPS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadps 35
  • 90.97 (n)
  • 98.36 (a)
Cadps 16
Cadps 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CADPS 35
  • 99.78 (n)
  • 100 (a)
CADPS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadps 35
  • 89.85 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CADPS 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves CADPS 35
  • 85.32 (n)
  • 96.36 (a)
CADPS 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CADPS 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cadps 35
  • 82.04 (n)
  • 95.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26179 35
zebrafish
(Danio rerio)
Actinopterygii cadpsa 35
  • 77.68 (n)
  • 88.85 (a)
cadpsa 36
  • 87 (a)
OneToMany
cadpsb 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Caps 35
  • 59.69 (n)
  • 61.63 (a)
Caps 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-31 35
  • 57.05 (n)
  • 55.46 (a)
unc-31 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for CADPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CADPS Gene

ENSEMBL:
Gene Tree for CADPS (if available)
TreeFam:
Gene Tree for CADPS (if available)

Paralogs for CADPS Gene

Paralogs for CADPS Gene

(1) SIMAP similar genes for CADPS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with CADPS: view

Variants for CADPS Gene

Sequence variations from dbSNP and Humsavar for CADPS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3344 -- 62,428,459(+) GACTA(C/T)TCTGG intron-variant
rs3411 -- 62,588,513(+) TCTTA(C/T)GCCTT intron-variant
rs17062 -- 62,399,056(+) ACTTG(C/G/T)CCTCA utr-variant-3-prime
rs167346 -- 62,789,118(+) GCAAC(A/G)TAAAA intron-variant
rs177442 -- 62,799,351(+) ctgga(A/G)gcaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADPS Gene

Variant ID Type Subtype PubMed ID
esv992591 CNV Deletion 20482838
esv274340 CNV Insertion 20981092
esv268322 CNV Insertion 20981092
nsv876876 CNV Gain 21882294
esv1691841 CNV Insertion 17803354
nsv437330 CNV Loss 16327808
esv2646380 CNV Deletion 19546169
esv22120 CNV Loss 19812545
esv1986039 CNV Deletion 18987734
nsv471783 CNV Loss 16327809
esv2663095 CNV Deletion 23128226
dgv605n27 CNV Loss 19166990
nsv517351 CNV Loss 19592680
nsv818144 CNV Loss 17921354
esv2421495 CNV Deletion 20811451
nsv460579 CNV Loss 19166990
nsv437331 CNV Loss 16327808
nsv876877 CNV Gain 21882294
nsv436384 CNV Deletion 17901297
esv27801 CNV Loss 19812545
esv2675183 CNV Deletion 23128226
nsv516380 CNV Loss 19592680
nsv876878 CNV Gain 21882294
nsv822107 CNV Gain 20364138
nsv460580 CNV Loss 19166990
dgv72n17 CNV Loss 16327808
nsv10277 CNV Loss 18304495
esv2676463 CNV Deletion 23128226
nsv517777 CNV Loss 19592680
nsv818146 CNV Loss 17921354
esv2421421 CNV Deletion 20811451
esv22376 CNV Loss 19812545
nsv441824 CNV CNV 18776908
nsv514152 CNV Loss 21397061
nsv876879 CNV Gain 21882294
nsv876880 CNV Gain 21882294

Variation tolerance for CADPS Gene

Residual Variation Intolerance Score: 2.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADPS Gene

HapMap Linkage Disequilibrium report
CADPS
Human Gene Mutation Database (HGMD)
CADPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADPS Gene

Disorders for CADPS Gene

MalaCards: The human disease database

(3) MalaCards diseases for CADPS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pineal gland cancer
  • malignant pineal region tumor
pineoblastoma
  • pineal pnet
angiodysplasia
  • angiodysplasia of stomach and duodenum with hemorrhage
- elite association
Search CADPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for CADPS

Genetic Association Database (GAD)
CADPS
Human Genome Epidemiology (HuGE) Navigator
CADPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADPS
genes like me logo Genes that share disorders with CADPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CADPS Gene

Publications for CADPS Gene

  1. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. (PMID: 18022372) Jockusch W.J. … Brose N. (Cell 2007) 23 67
  2. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). (PMID: 15857609) Binda A.V. … Levenson R. (Biochem. Pharmacol. 2005) 23 67
  3. Approaches to modeling crossbridges and calcium-dependent activation in cardiac muscle. (PMID: 15142743) Rice J.J. … de Tombe P.P. (Prog. Biophys. Mol. Biol. 2004) 23 67
  4. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. (PMID: 12659812) Cisternas F.A. … Ray P.N. (Genomics 2003) 23 67
  5. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. (PMID: 14530279) Speidel D. … Reim K. (J. Biol. Chem. 2003) 23 67

Products for CADPS Gene

Sources for CADPS Gene

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