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CADPS Gene

protein-coding   GIFtS: 60
GCID: GC03M062359

Ca++-Dependent Secretion Activator

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ca++-Dependent Secretion Activator1 2     Ca2+-Dependent Activator Protein For Secretion2
CAPS2 3 5     Ca2+-Dependent Secretion Activator2
Calcium-Dependent Activator Protein For Secretion 12 3     Ca2+-Regulated Cytoskeletal Protein2
CAPS-12 3     Calcium-Dependent Secretion Activator 12
CAPS12 3     KIAA11213
CADPS12     

External Ids:    HGNC: 14261   Entrez Gene: 86182   Ensembl: ENSG000001636187   OMIM: 6046675   UniProtKB: Q9ULU83   

Export aliases for CADPS gene to outside databases

Previous GC identifers: GC03M061249 GC03M061786 GC03M062238 GC03M062341


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CADPS Gene:
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the
Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows
ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate
(PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct
isoforms, are described. (provided by RefSeq, Aug 2008)

GeneCards Summary for CADPS Gene:
CADPS (Ca++-dependent secretion activator) is a protein-coding gene. Diseases associated with CADPS include pineoblastoma, and childhood medulloblastoma. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CADPS2.

UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and
neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles.
Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large
dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts
at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also
participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related
to Ca(2+) triggering (By similarity)

Gene Wiki entry for CADPS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CADPS gene promoter:
         NRSF form 1   ATF-2   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCADPS promoter sequence
   Search Chromatin IP Primers for CADPS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.2   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p21.1

CADPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADPS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M062359:  view genomic region     (about GC identifiers)

Start:
62,384,021 bp from pter      End:
62,861,064 bp from pter
Size:
477,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8 (See protein sequence)
Recommended Name: Calcium-dependent secretion activator 1  
Size: 1353 amino acids; 152786 Da
Subunit: Homodimer (By similarity). Interacts with RASL10B (By similarity). Interacts with the dopamine receptor
DRD2
Sequence caution: Sequence=AAA79701.1; Type=Frameshift; Positions=1305, 1317; Sequence=AAH15754.1; Type=Erroneous
initiation; Sequence=BAA86435.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CADPS:
1WI1 (3D)    
Secondary accessions: A6NF60 Q13339 Q6GQQ6 Q8N2Z5 Q8N3M7 Q8NFR0 Q96BC2
Alternative splicing: 5 isoforms:  Q9ULU8-1   Q9ULU8-2   Q9ULU8-3   Q9ULU8-4   Q9ULU8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CADPS: NX_Q9ULU8

Explore proteomics data for CADPS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CADPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003707.2  NP_899630.1  NP_899631.1  

    ENSEMBL proteins: 
     ENSP00000373215   ENSP00000418889   ENSP00000350632   ENSP00000283269   ENSP00000417568  
     ENSP00000418110   ENSP00000417827   ENSP00000420044   ENSP00000439528   ENSP00000418736  

    CADPS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CADPS
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CADPS
    GenScript Custom Purified and Recombinant Proteins Services for CADPS
    Novus Biologicals CADPS Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADPS

    CADPS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CADPS
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CADPS
    OriGene Custom Antibody Services for CADPS
    Novus Biologicals CADPS Antibodies
    Abcam antibodies for CADPS
    Cloud-Clone Corp. Antibodies for CADPS
    ThermoFisher Antibodies for CADPS
    LSBio Antibodies in human, mouse, rat for CADPS

    CADPS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CADPS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADPS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CADPS
    Cloud-Clone Corp. CLIAs for CADPS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR010439 Ca-dep_secretion_activator
     IPR014770 Munc13_1
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULU8

    ProtoNet protein and cluster: Q9ULU8

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
    Domain: The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It
    however does not mediate binding to DCVs (By similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 MHD1 (MUNC13 homology domain 1) domain
    Similarity: Contains 1 PH domain


    CADPS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAPS1_HUMAN, Q9ULU8
    Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and
    neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles.
    Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large
    dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts
    at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also
    participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related
    to Ca(2+) triggering (By similarity)

         Genatlas biochemistry entry for CADPS:
    ca2+ dependent activator protein for secretion,neural/endocrine specific cytosolic and peripheral membrane protein
    required for the exocytosis of secretory vesicles,phopholipid protein,specifically interacting with
    phosphotidylinositol 4,5 biphosphate

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17984325
    GO:0008289lipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    CADPS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CADPS:
     G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cadps):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system 

    CADPS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cadpstm1Bros for CADPS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CADPS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CADPS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADPS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADPS

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CADPS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADPS (see all 22):
    hsa-miR-3910 hsa-miR-30c hsa-miR-137 hsa-miR-30d hsa-miR-340 hsa-miR-124 hsa-miR-30a hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidCADPS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CADPS
    Predesigned siRNA for gene silencing in human, mouse, rat CADPS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CADPS

    Clone
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    OriGene clones in human, mouse for CADPS (see all 19)
    OriGene ORF clones in mouse, rat for CADPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CADPS (NM_183394)
    Sino Biological Human cDNA Clone for CADPS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADPS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CADPS
    Browse ESI BIO Cell Lines and PureStem Progenitors for CADPS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADPS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAPS1_HUMAN, Q9ULU8: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Cell junction, synapse (By similarity). Note=Membrane-associated to vesicles. Strongly enriched in synaptic
    fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for
    PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS1516133
    GO:0030054cell junction IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle ----
    GO:0045202synapse IEA--

    CADPS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CADPS: 
              Parkinson's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CADPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CADPS (Q9ULU82, 3 ENSP000003732154) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-65116 I2D: score=4 
    LUC7L2Q9Y3832, 3MINT-65116 I2D: score=4 
    PIP5K1AQ997552, 3, ENSP000003578834MINT-65290 I2D: score=4 STRING: ENSP00000357883
    DMDP115323, ENSP000003549234I2D: score=2 STRING: ENSP00000354923
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis TAS1516133
    GO:0015031protein transport IEA--
    GO:0016050vesicle organization IEA--
    GO:0016082synaptic vesicle priming IEA--
    GO:0050432catecholamine secretion IEA--

    CADPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CADPS (CAPS1)

    2 HMDB Compounds for CADPS    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    4 Novoseek inferred chemical compound relationships for CADPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 52.1 50 2335025 (2), 9162085 (2), 1973642 (2), 8111791 (2) (see all 18)
    nifedipine 41.2 1 7505666 (1)
    atp 14.9 1 8391760 (1)
    norepinephrine 10 2 9162085 (1)



    CADPS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CADPS gene (3 alternative transcripts): 
    NM_003716.3  NM_183393.2  NM_183394.2  

    Unigene Cluster for CADPS:

    Ca++-dependent secretion activator
    Hs.654933  [show with all ESTs]
    Unigene Representative Sequence: NM_003716
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383710(uc003dlk.1 uc003dll.2 uc003dlm.2 uc003dln.2 uc021wzv.1)
    ENST00000486172 ENST00000473635(uc003dlj.1) ENST00000357948 ENST00000474560
    ENST00000283269 ENST00000466621 ENST00000469292 ENST00000462768 ENST00000478408
    ENST00000478570 ENST00000463002 ENST00000491424 ENST00000468271 ENST00000478434
    ENST00000542833 ENST00000490424 ENST00000490353

    miRNA
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    Block miRNA regulation of human, mouse, rat CADPS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADPS (see all 22):
    hsa-miR-3910 hsa-miR-30c hsa-miR-137 hsa-miR-30d hsa-miR-340 hsa-miR-124 hsa-miR-30a hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidCADPS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CADPS
    Clone
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    OriGene ORF clones in mouse, rat for CADPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CADPS (NM_183394)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADPS
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CADPS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADPS
      QuantiTect SYBR Green Assays in human, mouse, rat CADPS
      QuantiFast Probe-based Assays in human, mouse, rat CADPS

    Additional mRNA sequence: 

    AB032947.2 AB593079.1 AF458662.1 AK127506.1 AL833895.1 BC015754.1 BC029460.1 BC072684.1 
    BC131731.1 BX647166.1 U36448.1 

    18 DOTS entries:

    DT.444874  DT.99940132  DT.95366284  DT.411196  DT.92015172  DT.91834197  DT.120880535  DT.40126441 
    DT.100774064  DT.95366283  DT.97862341  DT.101956582  DT.305191  DT.40213846  DT.426985  DT.95148105 
    DT.100653008  DT.91998835 

    Selected AceView cDNA sequences (see all 139):

    NM_183394 BM695093 BM698734 CA776541 BM690018 AL536464 BM711200 BQ187390 
    D56260 AA884606 BQ424357 CD106409 BM475890 Z38783 CR617234 BC015754 
    Z38694 Z42501 AV708392 NM_183393 NM_003716 BQ722151 BM128197 BU071288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CADPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGTAGTG
    CADPS Expression
    About this image


    CADPS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     NULL (Uncategorized)
             Neural rosettes
    CADPS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CADPS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654933

    UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
    Tissue specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and
    pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla,
    occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord

        Pathway & Disease-focused RT2 Profiler PCR Array including CADPS: 
              Parkinson's Disease in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CADPS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADPS
    QuantiTect SYBR Green Assays in human, mouse, rat CADPS
    QuantiFast Probe-based Assays in human, mouse, rat CADPS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CADPS gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadps1 , 5 Ca2+-dependent secretion activator1, 5 90.97(n)1
    98.36(a)1
      14 (6.37 cM)5
    270621  NM_001042617.11  NP_001036082.11 
     123725635 
    chicken
    (Gallus gallus)
    Aves CADPS1 Ca++-dependent secretion activator 85.32(n)
    96.36(a)
      416075  XM_001233834.3  XP_001233835.1 
    lizard
    (Anolis carolinensis)
    Reptilia CADPS6
    Ca++-dependent secretion activator
    95(a)
    1 ↔ 1
    GL343210.1(2802419-3144082)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.261792 Xenopus laevis transcribed sequence with weak similarity more 83.22(n)    CD329412.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadpsa1 Ca2+-dependent activator protein for secretion a 77.68(n)
    88.85(a)
      100333933  XM_005155845.1  XP_005155902.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Caps1 Calcium activated protein for secretion 59.69(n)
    61.63(a)
      49968  NM_001258510.2  NP_001245439.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-311 unc-31 57.05(n)
    55.46(a)
      178233  NM_001268735.1  NP_001255664.1 


    ENSEMBL Gene Tree for CADPS (if available)
    TreeFam Gene Tree for CADPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CADPS gene
    CADPS22  
    1 SIMAP similar gene for CADPS using alignment to 9 protein entries:     CAPS1_HUMAN (see all proteins):
    CADPS2

    CADPS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CADPS (see all 10753)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837802231,2
    --62383642(+) ATATAA/GTTGGC 3 -- ds50010--------
    rs1476193051,2
    --62383669(+) TGCAAA/TCACTG 3 -- ds50010--------
    rs1891865061,2
    --62383821(+) GCCCAC/TGGGTT 3 -- ds50010--------
    rs1906373741,2
    --62383911(+) CCAACA/GGTTTC 3 -- ds50010--------
    rs1829278841,2
    --62384023(+) ACGTAC/TATTCT 3 -- ut310--------
    rs1422455671,2
    --62384160(+) CCAGGA/GTTGTG 3 -- ut310--------
    rs67621641,2
    C,F,A,H--62384314(+) TATTCA/C/GTTTTT 6 -- ut31 ese316NS EA NA WA CSA 792
    rs745639771,2
    C,F--62384355(+) AATAAC/TATTTA 3 -- ut312Minor allele frequency- T:0.05CSA WA 120
    rs10565481,2
    C--62384481(-) AAAAAG/TGATGG 3 -- ut31 trp31Minor allele frequency- T:0.00NA 2
    rs1422359801,2
    --62384564(+) GGGGAA/GCAGAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CADPS (62384021 - 62634021 bp, first 250kb of CADPS)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CADPS (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676463CNV Deletion23128226
    esv2646380CNV Deletion19546169
    esv2421421CNV Deletion20811451
    nsv436384CNV Deletion17901297
    esv992591CNV Deletion20482838
    esv2663095CNV Deletion23128226
    esv2421495CNV Deletion20811451
    esv1986039CNV Deletion18987734
    esv2675183CNV Deletion23128226
    esv268322CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CADPS
    DNA2.0 Custom Variant and Variant Library Synthesis for CADPS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604667    OMIM disorders: --

    9 diseases for CADPS:    
    About MalaCards
    pineoblastoma    childhood medulloblastoma    primitive neuroectodermal tumor    medulloblastoma
    parkinson's disease    cerebritis    pancreatitis    breast cancer
    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for CADPS:
    Pineoblastoma     Childhood medulloblastoma

    CADPS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CADPS
    Human Genome Epidemiology (HuGE) Navigator: CADPS (4 documents)

    Export disorders for CADPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CADPS gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with CADPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. (PubMed id 12659812)1, 2, 9 Cisternas F.A.... Ray P.N. (Genomics 2003)
    2. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). (PubMed id 15857609)1, 2, 9 Binda A.V.... Levenson R. (Biochem. Pharmacol. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    8. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. (PubMed id 9289490)1, 2 Ann K.... Martin T.F.J. (J. Biol. Chem. 1997)
    9. A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. (PubMed id 1516133)1, 3 Walent J.H....Martin T.F. (Cell 1992)
    10. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. (PubMed id 14530279)1, 9 Speidel D.... Reim K. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8618 HGNC: 1426 AceView: CADPS Ensembl:ENSG00000163618 euGenes: HUgn8618
    ECgene: CADPS H-InvDB: CADPS

    (According to HUGE)
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    HUGE: KIAA1121

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CADPS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CADPS gene:
    Search GeneIP for patents involving CADPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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