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Aliases for CADPS Gene

Aliases for CADPS Gene

  • Calcium Dependent Secretion Activator 2 3 5
  • Calcium-Dependent Activator Protein For Secretion 1 3 4
  • Ca++-Dependent Secretion Activator 2 3
  • Ca2+ Dependent Secretion Activator 2 3
  • CAPS-1 3 4
  • CAPS1 3 4
  • CAPS 3 4
  • Ca2+-Dependent Activator Protein For Secretion 3
  • Calcium-Dependent Secretion Activator 1 3
  • Ca2+-Regulated Cytoskeletal Protein 3
  • KIAA1121 4
  • CADPS1 3
  • UNC-31 3

External Ids for CADPS Gene

Previous GeneCards Identifiers for CADPS Gene

  • GC03M061249
  • GC03M061786
  • GC03M062238
  • GC03M062341
  • GC03M062359

Summaries for CADPS Gene

Entrez Gene Summary for CADPS Gene

  • This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

GeneCards Summary for CADPS Gene

CADPS (Calcium Dependent Secretion Activator) is a Protein Coding gene. Diseases associated with CADPS include Pineoblastoma and Angiodysplasia. GO annotations related to this gene include protein kinase binding and lipid binding. An important paralog of this gene is CADPS2.

UniProtKB/Swiss-Prot for CADPS Gene

  • Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

Gene Wiki entry for CADPS Gene

Additional gene information for CADPS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADPS Gene

Genomics for CADPS Gene

Regulatory Elements for CADPS Gene

Enhancers for CADPS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H062585 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +288.3 288277 3 JUN YBX1 CEBPG GABPA JUND POLR2A MTA1 FOSL2 RCOR1 FOS CADPS GC03P062556 GC03M062779
GH03H062437 0.6 FANTOM5 12.5 +438.2 438193 0 ZSCAN4 ZSCAN29 BMI1 CADPS FEZF2 C3orf14 GC03P062465 LOC105377647
GH03H062873 0.8 ENCODE 5.9 +1.4 1411 1 GTF2F1 CTCF MXI1 ESRRA KLF1 ZNF777 ZNF76 RAD21 GLIS2 POLR2A CADPS GC03M062831
GH03H062883 0.9 ENCODE dbSUPER 5 -8.7 -8728 1 SMARCE1 NFRKB MNT FOXA1 ZNF217 GATA3 CTBP1 POU5F1 FOS RNU6-139P CADPS RPS10P10
GH03H062876 0.7 ENCODE 5.8 -0.9 -892 0 SMARCA5 ELF3 GTF2F1 MAX MNT MIER2 REST RARA POLR2A HSF1 ATXN7 CADPS RPS10P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CADPS on UCSC Golden Path with GeneCards custom track

Promoters for CADPS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000304356 389 401 ESRRA POLR2A CTBP2 EZH2
ENSR00000153563 1189 401 GTF2F1 CTCF MXI1 ESRRA KLF1 ZNF76 GLIS2 POLR2A ZBTB20 EZH2

Genomic Location for CADPS Gene

Chromosome:
3
Start:
62,398,346 bp from pter
End:
62,875,389 bp from pter
Size:
477,044 bases
Orientation:
Minus strand

Genomic View for CADPS Gene

Genes around CADPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADPS Gene

Proteins for CADPS Gene

  • Protein details for CADPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULU8-CAPS1_HUMAN
    Recommended name:
    Calcium-dependent secretion activator 1
    Protein Accession:
    Q9ULU8
    Secondary Accessions:
    • A6NF60
    • Q13339
    • Q6GQQ6
    • Q8N2Z5
    • Q8N3M7
    • Q8NFR0
    • Q96BC2

    Protein attributes for CADPS Gene

    Size:
    1353 amino acids
    Molecular mass:
    152786 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with RASL10B (By similarity). Interacts with the dopamine receptor DRD2.
    SequenceCaution:
    • Sequence=AAA79701.1; Type=Frameshift; Positions=1305, 1317; Evidence={ECO:0000305}; Sequence=AAH15754.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86435.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADPS Gene

    Alternative splice isoforms for CADPS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADPS Gene

Post-translational modifications for CADPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CADPS Gene

Domains & Families for CADPS Gene

Gene Families for CADPS Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CADPS Gene

Suggested Antigen Peptide Sequences for CADPS Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULU8

UniProtKB/Swiss-Prot:

CAPS1_HUMAN :
  • The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).
Domain:
  • The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).
genes like me logo Genes that share domains with CADPS: view

Function for CADPS Gene

Molecular function for CADPS Gene

GENATLAS Biochemistry:
ca2+ dependent activator protein for secretion,neural/endocrine specific cytosolic and peripheral membrane protein required for the exocytosis of secretory vesicles,phopholipid protein,specifically interacting with phosphotidylinositol 4,5 biphosphate
UniProtKB/Swiss-Prot Function:
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

Phenotypes From GWAS Catalog for CADPS Gene

Gene Ontology (GO) - Molecular Function for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17984325
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CADPS: view
genes like me logo Genes that share phenotypes with CADPS: view

Animal Models for CADPS Gene

MGI Knock Outs for CADPS:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CADPS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADPS Gene

Localization for CADPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADPS Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADPS gene
Compartment Confidence
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 1516133
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CADPS: view

Pathways & Interactions for CADPS Gene

SuperPathways for CADPS Gene

No Data Available

Gene Ontology (GO) - Biological Process for CADPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis TAS 1516133
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IEA --
GO:0016079 synaptic vesicle exocytosis IEA --
genes like me logo Genes that share ontologies with CADPS: view

No data available for Pathways by source and SIGNOR curated interactions for CADPS Gene

Drugs & Compounds for CADPS Gene

(7) Drugs for CADPS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Citrate Approved Pharma Target, agonist 0
Calcium Phosphate Approved Pharma Target, agonist 0
Dopamine Approved Pharma Full agonist, Agonist 3926
calcium Nutra 0
genes like me logo Genes that share compounds with CADPS: view

Transcripts for CADPS Gene

Unigene Clusters for CADPS Gene

Ca++-dependent secretion activator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CADPS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CADPS Gene

No ASD Table

Relevant External Links for CADPS Gene

GeneLoc Exon Structure for
CADPS
ECgene alternative splicing isoforms for
CADPS

Expression for CADPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CADPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADPS Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.2), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cortex (x4.2), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for CADPS Gene

This gene is overexpressed in Brain (22.3), Frontal cortex (22.3), Retina (10.1), and Fetal Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CADPS Gene



Protein tissue co-expression partners for CADPS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CADPS Gene:

CADPS

SOURCE GeneReport for Unigene cluster for CADPS Gene:

Hs.654933

mRNA Expression by UniProt/SwissProt for CADPS Gene:

Q9ULU8-CAPS1_HUMAN
Tissue specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.

Evidence on tissue expression from TISSUES for CADPS Gene

  • Nervous system(4.9)
  • Skin(4)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with CADPS: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CADPS Gene

Orthologs for CADPS Gene

This gene was present in the common ancestor of animals.

Orthologs for CADPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADPS 33 34
  • 99.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 96 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CADPS 33 34
  • 93.56 (n)
cow
(Bos Taurus)
Mammalia CADPS 33 34
  • 93.34 (n)
oppossum
(Monodelphis domestica)
Mammalia CADPS 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadps 33 16 34
  • 90.97 (n)
rat
(Rattus norvegicus)
Mammalia Cadps 33
  • 89.85 (n)
chicken
(Gallus gallus)
Aves CADPS 33 34
  • 85.32 (n)
lizard
(Anolis carolinensis)
Reptilia CADPS 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cadps 33
  • 82.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26179 33
zebrafish
(Danio rerio)
Actinopterygii cadpsb 34
  • 84 (a)
OneToMany
cadpsa 33 34
  • 77.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Caps 33 34
  • 59.69 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-31 33 34
  • 57.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToMany
Species where no ortholog for CADPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CADPS Gene

ENSEMBL:
Gene Tree for CADPS (if available)
TreeFam:
Gene Tree for CADPS (if available)

Paralogs for CADPS Gene

Paralogs for CADPS Gene

(1) SIMAP similar genes for CADPS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with CADPS: view

Variants for CADPS Gene

Sequence variations from dbSNP and Humsavar for CADPS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193921128 Uncertain significance 62,765,942(-) TTCAG(A/G)CTTTC reference, missense
rs1000014076 -- 62,836,495(+) AGGGA(A/G)AAGTG intron-variant
rs1000018175 -- 62,398,828(+) TTATA(A/T)GAGTA utr-variant-3-prime
rs1000019406 -- 62,509,567(+) ACCTC(A/C)ACATC intron-variant
rs1000020397 -- 62,871,120(+) AAGTC(C/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADPS Gene

Variant ID Type Subtype PubMed ID
dgv4756n100 CNV loss 25217958
dgv605n27 CNV loss 19166990
dgv72n17 CNV loss 16327808
esv1691841 CNV insertion 17803354
esv1986039 CNV deletion 18987734
esv22120 CNV loss 19812545
esv22376 CNV loss 19812545
esv2421421 CNV deletion 20811451
esv2421495 CNV deletion 20811451
esv2646380 CNV deletion 19546169
esv2663095 CNV deletion 23128226
esv2675183 CNV deletion 23128226
esv2676463 CNV deletion 23128226
esv2760736 CNV loss 21179565
esv2760748 CNV loss 21179565
esv27801 CNV loss 19812545
esv3304043 CNV mobile element insertion 20981092
esv3310068 CNV mobile element insertion 20981092
esv3325289 CNV insertion 20981092
esv3364849 CNV insertion 20981092
esv3410609 CNV insertion 20981092
esv3429228 CNV insertion 20981092
esv3568813 CNV loss 25503493
esv3568814 CNV loss 25503493
esv3568815 CNV loss 25503493
esv3596375 CNV loss 21293372
esv3596377 CNV loss 21293372
esv3596378 CNV loss 21293372
esv992591 CNV deletion 20482838
nsv1011522 CNV loss 25217958
nsv10277 CNV loss 18304495
nsv1141432 CNV duplication 24896259
nsv436384 CNV deletion 17901297
nsv437330 CNV loss 16327808
nsv437331 CNV loss 16327808
nsv441824 CNV loss 18776908
nsv460579 CNV loss 19166990
nsv460580 CNV loss 19166990
nsv471783 CNV loss 16327809
nsv476542 CNV novel sequence insertion 20440878
nsv514152 CNV loss 21397061
nsv516380 CNV loss 19592680
nsv517351 CNV loss 19592680
nsv517777 CNV loss 19592680
nsv590442 CNV loss 21841781
nsv590443 CNV loss 21841781
nsv590444 CNV loss 21841781
nsv590445 CNV loss 21841781
nsv818144 CNV loss 17921354
nsv818146 CNV loss 17921354
nsv822107 CNV gain 20364138
nsv954870 CNV deletion 24416366

Variation tolerance for CADPS Gene

Residual Variation Intolerance Score: 2.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADPS Gene

Human Gene Mutation Database (HGMD)
CADPS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CADPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADPS Gene

Disorders for CADPS Gene

MalaCards: The human disease database

(2) MalaCards diseases for CADPS Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pineoblastoma
  • pineal pnet
angiodysplasia
  • angiodysplasia of stomach and duodenum with hemorrhage
- elite association - COSMIC cancer census association via MalaCards
Search CADPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for CADPS

Genetic Association Database (GAD)
CADPS
Human Genome Epidemiology (HuGE) Navigator
CADPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADPS
genes like me logo Genes that share disorders with CADPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CADPS Gene

Publications for CADPS Gene

  1. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). (PMID: 15857609) Binda AV … Levenson R (Biochemical pharmacology 2005) 3 4 22 60
  2. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. (PMID: 12659812) Cisternas FA … Ray PN (Genomics 2003) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CADPS Gene

Sources for CADPS Gene

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