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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CADPS Gene

protein-coding   GIFtS: 57
GCID: GC03M062359

Ca++-dependent secretion activator
 Explore 13 diseases affiliated with
CADPS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CADPS    

Aliases
for CADPS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ca++-Dependent Secretion Activator1 2     CADPS12
CAPS1 2 3 5     Ca2+-Dependent Activator Protein For Secretion2
CAPS11 2 3     Ca2+-Dependent Secretion Activator2
KIAA11211 3     Ca2+-Regulated Cytoskeletal Protein2
Calcium-Dependent Activator Protein For Secretion 12 3     Calcium-Dependent Secretion Activator 12
CAPS-12 3     

External Ids:    HGNC: 14261   Entrez Gene: 86182   Ensembl: ENSG000001636187   OMIM: 6046675   UniProtKB: Q9ULU83   

Export aliases for CADPS gene to outside databases

Previous GC identifers: GC03M061249 GC03M061786 GC03M062238 GC03M062341


Summaries
for CADPS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CADPS:
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the
Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent
priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative
splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. (provided by
RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides.
Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates
catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles
(DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step
following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small
clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By
similarity)

Gene Wiki entry for CADPS


Genomic Views
for CADPS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CADPS gene promoter:
         NRSF form 1   ATF-2   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CADPS promoter sequence
   Search SABiosciences Chromatin IP Primers for CADPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.2   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p21.1

CADPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADPS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M062359:  view genomic region     (about GC identifiers)

Start:
 62,384,021 bp from pter      End:
 62,861,064 bp from pter
Size:
 477,044 bases      Orientation:
 minus strand

Proteins
for CADPS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8 (See protein sequence)
Recommended Name: Calcium-dependent secretion activator 1  
Size: 1353 amino acids; 152786 Da
Subunit: Homodimer (By similarity). Interacts with RASL10B (By similarity). Interacts with the dopamine receptor DRD2
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell
junction, synapse (By similarity). Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions.
Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over
PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity)
Sequence caution: Sequence=AAA79701.1; Type=Frameshift; Positions=1305, 1317; Sequence=AAH15754.1; Type=Erroneous
initiation; Sequence=BAA86435.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CADPS:
1WI1 (3D)    
Secondary accessions: A6NF60 Q13339 Q6GQQ6 Q8N2Z5 Q8N3M7 Q8NFR0 Q96BC2
Alternative splicing: 5 isoforms:  Q9ULU8-1   Q9ULU8-2   Q9ULU8-3   Q9ULU8-4   Q9ULU8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CADPS: NX_Q9ULU8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULU8

    • CADPS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_003707.2  NP_899630.1  NP_899631.1  

    ENSEMBL proteins: 
     ENSP00000373215   ENSP00000418889   ENSP00000350632   ENSP00000283269   ENSP00000417568  
     ENSP00000418110   ENSP00000417827   ENSP00000420044   ENSP00000439528   ENSP00000418736  

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    OriGene Protein Over-expression Lysate: CADPS
    OriGene Custom Protein Services for CADPS 
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    Novus Biologicals CADPS Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CADPS

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS1516133
    GO:0030054cell junction IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle ----
    GO:0045202synapse IEA--


    CADPS for ontologies           About GeneDecksing



    CADPS Antibody Products: 
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    Uscn Antibodies for CADPS
    ThermoFisher Antibodies for CADPS

    Assay Products for CADPS: 
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    Uscn ELISAs and CLIAs for CADPS

    Protein Domains /
    Families
    for CADPS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CADPS for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR010439 Ca-dep_secretion_activator
     IPR014770 Munc13_1
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9ULU8

    ProtoNet protein and cluster: Q9ULU8

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
    Domain: The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however
    does not mediate binding to DCVs (By similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 MHD1 (MUNC13 homology domain 1) domain
    Similarity: Contains 1 PH domain


    Function
    for CADPS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
    Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides.
    Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates
    catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles
    (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step
    following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small
    clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By
    similarity)

         Genatlas biochemistry entry for CADPS:
    ca2+ dependent activator protein for secretion,neural/endocrine specific cytosolic and peripheral membrane protein
    required for the exocytosis of secretory vesicles,phopholipid protein,specifically interacting with
    phosphotidylinositol 4,5 biphosphate

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADPS
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CADPS (see all 22):
    hsa-miR-3910 hsa-miR-30c hsa-miR-137 hsa-miR-30d hsa-miR-340 hsa-miR-124 hsa-miR-30a hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmid: CADPS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADPS (see all 7)
    OriGene shRNA RFP: CADPS
    OriGene siRNA: CADPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADPS

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADPS (see all 7)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CADPS (NM_183394)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADPS 

    Cell Line
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    Search LifeMap BioReagents cell lines for CADPS

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADPS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI17984325
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--


    CADPS for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CADPS:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Cadpstm1Bros for CADPS
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cadps):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system 

    CADPS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CADPS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CADPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for CADPS (Q9ULU82, 3 ENSP000003732154) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-65116 I2D: score=4 
    LUC7L2Q9Y3832, 3MINT-65116 I2D: score=4 
    PIP5K1AQ997552, 3, ENSP000003578834MINT-65290 I2D: score=4 STRING: ENSP00000357883
    DMDP115323, ENSP000003549234I2D: score=2 STRING: ENSP00000354923
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis TAS1516133
    GO:0015031protein transport IEA--
    GO:0016050vesicle organization IEA--
    GO:0016082synaptic vesicle priming IEA--
    GO:0045956positive regulation of calcium ion-dependent exocytosis ----


    CADPS for ontologies           About GeneDecksing



    Drugs & Compounds
    for CADPS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CADPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CADPS

    2 HMDB Compounds for CADPS    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    4 Novoseek chemical compound relationships for CADPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 52.1 50 2335025 (2), 9162085 (2), 1973642 (2), 8111791 (2) (see all 18)
    nifedipine 41.2 1 7505666 (1)
    atp 14.9 1 8391760 (1)
    norepinephrine 10 2 9162085 (1)

    Search CenterWatch for drugs/clinical trials and news about CADPS / CAPS1 

    Transcripts
    for CADPS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CADPS gene (3 alternative transcripts): 
    NM_003716.3  NM_183393.2  NM_183394.2  

    Unigene Cluster for CADPS:

    Ca++-dependent secretion activator
    Hs.654933  [show with all ESTs]
    Unigene Representative Sequence: NM_003716
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383710(uc003dlk.1 uc003dll.2 uc003dlm.2 uc003dln.2 uc021wzv.1)
    ENST00000486172 ENST00000473635(uc003dlj.1) ENST00000357948 ENST00000474560
    ENST00000283269 ENST00000466621 ENST00000469292 ENST00000462768 ENST00000478408
    ENST00000478570 ENST00000463002 ENST00000491424 ENST00000468271 ENST00000478434
    ENST00000542833 ENST00000490424 ENST00000490353

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADPS
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CADPS (see all 22):
    hsa-miR-3910 hsa-miR-30c hsa-miR-137 hsa-miR-30d hsa-miR-340 hsa-miR-124 hsa-miR-30a hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmid: CADPS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADPS (see all 7)
    OriGene shRNA RFP: CADPS
    OriGene siRNA: CADPS
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB032947.2 AB593079.1 AF458662.1 AK127506.1 AL833895.1 BC015754.1 BC029460.1 BC072684.1 
    BC131731.1 BX647166.1 U36448.1 

    18 DOTS entries:

    DT.444874  DT.99940132  DT.95366284  DT.411196  DT.92015172  DT.91834197  DT.120880535  DT.40126441 
    DT.100774064  DT.95366283  DT.97862341  DT.101956582  DT.305191  DT.40213846  DT.426985  DT.95148105 
    DT.100653008  DT.91998835 

    24/139 AceView cDNA sequences (see all 139):

    NM_183394 BM695093 BM698734 CA776541 BM690018 BM711200 AL536464 BQ187390 
    D56260 AA884606 BQ424357 BM475890 CD106409 Z38783 CR617234 Z38694 
    BC015754 Z42501 NM_003716 AV708392 BQ722151 NM_183393 AI912173 BX492098 

    GeneLoc Exon Structure


    Expression
    for CADPS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CADPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAGTAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CADPS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cartilage-like cells (Differentiation of s...)Cartilage

    See CADPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CADPS

    SOURCE GeneReport for Unigene cluster: Hs.654933

    UniProtKB/Swiss-Prot: CAPS1_HUMAN, Q9ULU8
    Tissue specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas
    and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole,
    frontal and temporal lobes, and putamen, as well as weak expression in spinal cord

        SABiosciences Expression via Pathway-Focused PCR Array including CADPS: 
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADPS

    Orthologs
    for CADPS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CADPS gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cadps1 , 5 Ca2+-dependent secretion activator1, 5 91.22(n)1
    98.74(a)1    		   14 (6.37 cM)5
    270621  NM_012061.31  NP_036191.21 
     123725635 
    chicken
    (Gallus gallus)    		 Aves CADPS1 Ca++-dependent secretion activator 85.51(n)
    96.76(a)    		   416075  XM_001233834.2  XP_001233835.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CADPS6
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343210.1(2802469-3070657)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.261792 Xenopus laevis transcribed sequence with weak similarity more 83.22(n)    CD329412.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cadpsa1 Ca2+-dependent activator protein for secretion a 77.77(n)
    88.87(a)    		   100333933  XM_002663767.2  XP_002663813.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Caps1 Calcium activated protein for secretion 58.61(n)
    61.82(a)    		   49968  NM_001031860.1  NP_001027031.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-311 Protein UNC-31 57.05(n)
    55.27(a)    		   178233  NM_070036.3  NP_502437.3 


    ENSEMBL Gene Tree for CADPS (if available)
    TreeFam Gene Tree for CADPS (if available) 

    Paralogs
    for CADPS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CADPS gene
    CADPS22  
    1 SIMAP similar gene for CADPS using alignment to 9 protein entries:     CAPS1_HUMAN (see all proteins):
    CADPS2

    CADPS for paralogs           About GeneDecksing



    Genomic Variants
    for CADPS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9228 NCBI SNPs in CADPS are shown (see all 9228)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1837802231,2
    		--62383642(+) ATATAA/GTTGGC 3 -- ds50010--------
    rs1476193051,2
    		--62383669(+) TGCAAA/TCACTG 3 -- ds50010--------
    rs1891865061,2
    		--62383821(+) GCCCAC/TGGGTT 3 -- ds50010--------
    rs1906373741,2
    		--62383911(+) CCAACA/GGTTTC 3 -- ds50010--------
    rs1829278841,2
    		--62384023(+) ACGTAC/TATTCT 3 -- ut310--------
    rs1422455671,2
    		--62384160(+) CCAGGA/GTTGTG 3 -- ut310--------
    rs67621641,2
    		C,F,A,H,--62384314(+) TATTCA/C/GTTTTT 6 -- ut31 ese316NS EA NA WA CSA 792
    rs745639771,2
    		--62384355(+) AATAAC/TATTTA 3 -- ut312Minor allele frequency- T:0.05CSA WA 120
    rs10565481,2
    		C--62384481(-) AAAAAG/TGATGG 3 -- ut31 trp31Minor allele frequency- T:0.00NA 2
    rs1422359801,2
    		--62384564(+) GGGGAA/GCAGAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CADPS (62384021 - 62634021 bp, first 250kb of CADPS)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 31 variations for CADPS
         15/25 CNVs (see all 25): 51141 63478 38499 79781 51143 1055 22906 91331 1056 51142 44113 9998 9999 53422 79782
         6 Indels: 79780 91330 51138 51139 10739 10738

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CADPS
    DNA2.0 Custom Variant and Variant Library Synthesis for CADPS

    Disorders / Diseases
    for CADPS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CADPS for disorders           About GeneDecksing

    OMIM gene information: 604667    OMIM disorders: --

    13 diseases for CADPS:    About MalaCards
    primitive neuroectodermal tumor    neuroectodermal tumors    childhood medulloblastoma    pineoblastoma
    hepatitis b    hepatocellular carcinoma    parkinson's disease    medulloblastoma
    pharyngitis    hepatitis    carcinoma    cerebritis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CADPS:
    Pineoblastoma     Childhood medulloblastoma
    Human Genome Epidemiology (HuGE) Navigator: CADPS (4 documents)

    Export disorders for CADPS gene to outside databases

    Publications
    for CADPS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CADPS gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CADPS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. (PubMed id 12659812)1, 2, 9 Cisternas F.A.... Ray P.N. (2003)
    2. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). (PubMed id 15857609)1, 2, 9 Binda A.V.... Levenson R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
    6. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. (PubMed id 9289490)1, 2 Ann K.... Martin T.F.J. (1997)
    7. A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. (PubMed id 1516133)1, 3 Walent J.H....Martin T.F. (1992)
    8. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. (PubMed id 14530279)1, 9 Speidel D.... Reim K. (2003)
    9. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    10. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)

    External Searches for CADPS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CADPS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8618 HGNC: 1426 AceView: CADPS Ensembl:ENSG00000163618 euGenes: HUgn8618
    ECgene: CADPS H-InvDB: CADPS

    Other Databases showing CADPS gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1121

    Specialized Databases showing CADPS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CADPS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CADPS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CADPS gene:
    Search GeneIP for patents involving CADPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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    About This Section

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     CADPS Proteins, Antibodies, CLIAs, and ELISAs
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