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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CADM4 Gene

protein-coding   GIFtS: 55
GCID: GC19M044126

cell adhesion molecule 4

(Previous names: immunoglobulin superfamily, member 4C )
(Previous symbol: IGSF4C)
 Explore 5 diseases affiliated with
CADM4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CADM4    

Aliases
for CADM4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Adhesion Molecule 41 2     TSLC1-Like Protein 22 3
IGSF4C1 2 3 5     SynCAM41
TSLL21 2 3 5     Nectin-Like 42
NECL42 3 5     SynCAM41
Necl-41 2     TSLC1-Like 22
Immunoglobulin Superfamily, Member 4C1 2     IgSF4C3
Immunoglobulin Superfamily Member 4C2 3     NECL-43
Nectin-Like Protein 42 3     SYNCAM45

External Ids:    HGNC: 308251   Entrez Gene: 1997312   Ensembl: ENSG000001057677   OMIM: 6097445   UniProtKB: Q8NFZ83   

Export aliases for CADM4 gene to outside databases

Previous GC identifers: GC19M048821 GC19M040557


Summaries
for CADM4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May
have tumor-suppressor activity




Genomic Views
for CADM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CADM4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CADM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

CADM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044126:  view genomic region     (about GC identifiers)

Start:
 44,126,522 bp from pter      End:
 44,143,991 bp from pter
Size:
 17,470 bases      Orientation:
 minus strand

Proteins
for CADM4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8 (See protein sequence)
Recommended Name: Cell adhesion molecule 4 precursor  
Size: 388 amino acids; 42785 Da
Subunit: Monomer and homodimer
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAC32740.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R7L5 Q9Y4A4

Explore the universe of human proteins at neXtProt for CADM4: NX_Q8NFZ8

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFZ8

    • CADM4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_660339.1  
    ENSEMBL proteins: 
     ENSP00000222374  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM4 (IGSF4C/SynCAM4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CADM4
    OriGene Protein Over-expression Lysate: CADM4
    OriGene Custom Protein Services for CADM4 
    GenScript Custom Purified and Recombinant Proteins Services for CADM4
    Novus Biologicals CADM4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CADM4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    CADM4 for ontologies           About GeneDecksing



    CADM4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CADM4 (IGSF4C/SynCAM4)
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    Novus Biologicals CADM4 Antibodies
    Abcam antibodies for CADM4 
    Uscn Antibodies for CADM4
    ThermoFisher Antibodies for CADM4

    Assay Products for CADM4: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CADM4

    Protein Domains /
    Families
    for CADM4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CADM4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFZ8

    ProtoNet protein and cluster: Q8NFZ8

    5/6 Blocks protein families (see all 6):
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for CADM4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May
    have tumor-suppressor activity

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM4
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CADM4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM4 (see all 7)
    OriGene shRNA RFP: CADM4
    OriGene siRNA: CADM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CADM4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CADM4
    Search LifeMap BioReagents cell lines for CADM4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4

    4 GenomeRNAi human phenotypes for CADM4:
     Decreased cell number  Increased circadian period len  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 


    Pathways & Interactions
    for CADM4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CADM4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CADM4 (Q8NFZ82, 3 ENSP000002223744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496742, 3MINT-8252714 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254833 I2D: score=2 
    CNKSR1Q969H43, ENSP000003546094I2D: score=1 STRING: ENSP00000354609
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    CADM4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CADM4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CADM4

    2 HMDB Compounds for CADM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about CADM4 

    Transcripts
    for CADM4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CADM4 gene: 
    NM_145296.1  

    Unigene Cluster for CADM4:

    Cell adhesion molecule 4
    Hs.370984  [show with all ESTs]
    Unigene Representative Sequence: NM_145296
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222374(uc002oxc.1)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM4
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CADM4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM4 (see all 7)
    OriGene shRNA RFP: CADM4
    OriGene siRNA: CADM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CADM4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CADM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM4

    Additional cDNA sequence: 

    AF363368.1 AK313028.1 BC068457.1 BC113963.1 

    6 DOTS entries:

    DT.205521  DT.400116  DT.40126806  DT.91642811  DT.92418719  DT.70102083 

    24/79 AceView cDNA sequences (see all 79):

    BF002720 AI076878 BC068457 BG911369 NM_145296 CD516265 AI991767 AW613042 
    BM931353 AI805103 AI636231 BF508315 AI050793 BE222930 BX440536 AI375610 
    AF363368 AI743967 BM716721 BM674356 AI913589 BX104294 BX463698 AI589568 

    GeneLoc Exon Structure


    Expression
    for CADM4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CADM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTTATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CADM4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CADM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CADM4

    SOURCE GeneReport for Unigene cluster: Hs.370984

    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs

        SABiosciences Custom PCR Arrays for CADM4
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4

    Orthologs
    for CADM4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CADM4 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CADM46
    		 --
    		 65(a)
    		 1 ↔ 1
    		 Un(54954122-54956786)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.289762 Xenopus laevis transcribed sequence with weak similarity to protein refNP_055148.1 (H.sapiens) immunoglobulin superfamily, member 4 [Homo sapiens] less 76.14(n)    CD324788.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cadm41 cell adhesion molecule 4 62.7(n)
    60.58(a)    		   492787  NM_001007428.1  NP_001007429.1 


    ENSEMBL Gene Tree for CADM4 (if available)
    TreeFam Gene Tree for CADM4 (if available) 

    Paralogs
    for CADM4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CADM4 gene
    PVR2  CRTAM2  CADM12  PVRL42  PVRL32  CADM32  PVRL22  CADM22  
    PVRL12  
    3 SIMAP similar genes for CADM4 using alignment to 1 protein entry:     CADM4_HUMAN:
    CADM1    CADM3    CADM2

    CADM4 for paralogs           About GeneDecksing



    Genomic Variants
    for CADM4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 NCBI SNPs in CADM4 are shown (see all 270)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136855881,2
    		--44126043(+) TCACCG/ATGGAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs789960571,2
    		F,--44126091(+) GTTATT/GTTTTA 1 -- ds50012Minor allele frequency- G:0.07WA EA 238
    rs1140147711,2
    		F,--44126134(+) ATGAAT/CGAGAG 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1871643911,2
    		--44126227(+) ATTCAA/GAGTTC 1 -- ds50010--------
    rs346374721,2
    		C,F,H,--44126279(+) GGGTCC/TGGGCC 1 -- ds500121Minor allele frequency- T:0.23NS EA NA CSA WA 2348
    rs1153086441,2
    		F,--44126365(+) GTTTCT/CGGGGA 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs735565841,2
    		C,--44126389(+) TCAGTG/AAGGTC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs4332261,2
    		C,F,A,H,--44126738(+) ACCATA/GAAGAC 1 -- ut3128Minor allele frequency- G:0.26MN NS EA NA WA CSA 2951
    rs769249641,2
    		F,--44126955(+) AGTTAT/AGACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1489680981,2
    		C,--44127116(+) CCCTG-/CCCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CADM4 (44126522 - 44143991 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CADM4
         1 CNV: 73382

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CADM4
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM4

    Disorders / Diseases
    for CADM4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CADM4 for disorders           About GeneDecksing

    OMIM gene information: 609744    OMIM disorders: --

    5 diseases for CADM4:    About MalaCards
    renal clear cell carcinoma    osteoporosis    colon cancer    prostatitis
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: CADM4 (1 document)

    Export disorders for CADM4 gene to outside databases

    Publications
    for CADM4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CADM4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CADM4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)1, 2, 3, 9 Fukuhara H.... Murakami Y. (2001)
    2. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. (PubMed id 16261159)1, 2 Williams Y.N....Murakami Y. (2006)
    3. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (PubMed id 21544807)1 Nagata M....Murakami Y. (2012)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953)1 Karasik D....Demissie S. (2010)
    7. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PubMed id 19565570)1 Raveh S....Ben-Ze'ev A. (2009)
    8. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. (PubMed id 16825666)1 Giallourakis C....Xavier R. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    External Searches for CADM4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CADM4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199731 HGNC: 30825 AceView: IGSF4C Ensembl:ENSG00000105767 euGenes: HUgn199731
    ECgene: CADM4 H-InvDB: CADM4

    Other Databases showing CADM4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CADM4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CADM4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CADM4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CADM4 gene:
    Search GeneIP for patents involving CADM4

    Licensable Technologies for CADM4 gene:
    Weizmann Institute:Regulation of Myelination by Nectin-like molecules
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CADM4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     OriGene Antibodies for CADM4   OriGene shRNA RFP for CADM4  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CADM4
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     GenScript Custom Purified and Recombinant Proteins Services for CADM4 GenScript cDNA clones with any tag delivered in your preferred vector for CADM4
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     Search Regulatory tfbs for CADM4
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     Browse Sino Biological Proteins and Antibodies
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     Antibodies/Proteins Production Services
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     Novus Tissue Slides
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     CADM4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CADM4
     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for CADM4
     Browse SwitchGear Promoter luciferase reporter plasmids for CADM4
     ThermoFisher Antibodies for CADM4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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