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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CADM4 Gene

protein-coding   GIFtS: 55
GCID: GC19M044126

Cell Adhesion Molecule 4

(Previous names: immunoglobulin superfamily, member 4C)
(Previous symbol: IGSF4C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Adhesion Molecule 41 2     TSLC1-Like Protein 22 3
IGSF4C1 2 3 5     Necl-42
NECL42 3 5     synCAM42
TSLL22 3 5     TSLC1-Like 22
Immunoglobulin Superfamily, Member 4C1 2     IgSF4C3
Nectin-Like 41 2     NECL-43
Immunoglobulin Superfamily Member 4C2 3     SYNCAM45
Nectin-Like Protein 42 3     

External Ids:    HGNC: 308251   Entrez Gene: 1997312   Ensembl: ENSG000001057677   OMIM: 6097445   UniProtKB: Q8NFZ83   

Export aliases for CADM4 gene to outside databases

Previous GC identifers: GC19M048821 GC19M040557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CADM4 Gene: 
CADM4 (cell adhesion molecule 4) is a protein-coding gene. Diseases associated with CADM4 include renal clear cell carcinoma, and colon cancer. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity.
May have tumor-suppressor activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CADM4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CADM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

CADM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044126:  view genomic region     (about GC identifiers)

Start:
44,126,520 bp from pter      End:
44,143,991 bp from pter
Size:
17,472 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8 (See protein sequence)
Recommended Name: Cell adhesion molecule 4 precursor  
Size: 388 amino acids; 42785 Da
Subunit: Monomer and homodimer
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAC32740.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R7L5 Q9Y4A4

Explore the universe of human proteins at neXtProt for CADM4: NX_Q8NFZ8

Explore proteomics data for CADM4 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFZ8

  • CADM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CADM4 Protein Expression
    REFSEQ proteins: NP_660339.1  
    ENSEMBL proteins: 
     ENSP00000222374  

    Human Recombinant Protein Products for CADM4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM4 (IGSF4C/SynCAM4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CADM4
    OriGene Protein Over-expression Lysate for CADM4
    OriGene MassSpec for CADM4 
    OriGene Custom Protein Services for CADM4
    GenScript Custom Purified and Recombinant Proteins Services for CADM4
    Novus Biologicals CADM4 Lysate
    Sino Biological Recombinant Protein for CADM4
    Sino Biological Cell Lysate for CADM4 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CADM4 for ontologies           About GeneDecksing



    CADM4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CADM4 (IGSF4C/SynCAM4)
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    OriGene Custom Antibody Services for CADM4
    GenScript Custom Superior Antibodies Services for CADM4
    Novus Biologicals CADM4 Antibodies
    Abcam antibodies for CADM4
    Cloud-Clone Corp. Antibodies for CADM4 
    ThermoFisher Antibodies for CADM4
    LSBio Antibodies in human, mouse, rat for CADM4 

    Assay Products for CADM4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CADM4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CADM4 
    Cloud-Clone Corp. CLIAs for CADM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFZ8

    ProtoNet protein and cluster: Q8NFZ8

    5/6 Blocks protein domains (see all 6):
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CADM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM4_HUMAN, Q8NFZ8
    Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity.
    May have tumor-suppressor activity

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CADM4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CADM4:
     Decreased cell number  Increased circadian period len  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CADM4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CADM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADM4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADM4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM4
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCADM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CADM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CADM4
    Sirion Biotech Customized adenovirus for overexpression of CADM4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CADM4 (see all 6)
    OriGene ORF clones in mouse, rat for CADM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    Sino Biological Human cDNA Clone for CADM4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4
    Sirion Biotech Customized lentivirus for stable overexpression of CADM4 
                         Customized lentivirus expression plasmids for stable overexpression of CADM4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CADM4
    Search LifeMap BioReagents cell lines for CADM4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CADM4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CADM4 (Q8NFZ82, 3 ENSP000002223744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496742, 3MINT-8252714 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254833 I2D: score=2 
    CNKSR1Q969H43, ENSP000003546094I2D: score=1 STRING: ENSP00000354609
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    CADM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CADM4

    2 HMDB Compounds for CADM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about CADM4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CADM4 gene: 
    NM_145296.1  

    Unigene Cluster for CADM4:

    Cell adhesion molecule 4
    Hs.370984  [show with all ESTs]
    Unigene Representative Sequence: NM_145296
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222374(uc002oxc.1) ENST00000593506
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM4
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCADM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CADM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM4
    Clone
    Products:
         
    OriGene clones in human, mouse for CADM4 (see all 6)
    OriGene ORF clones in mouse, rat for CADM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4
    Sirion Biotech Customized lentivirus for stable overexpression of CADM4 
                         Customized lentivirus expression plasmids for stable overexpression of CADM4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CADM4
    OriGene qSTAR qPCR primer pairs in human, mouse for CADM4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CADM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM4

    Additional mRNA sequence: 

    AF363368.1 AK313028.1 BC068457.1 BC113963.1 

    6 DOTS entries:

    DT.205521  DT.400116  DT.40126806  DT.91642811  DT.92418719  DT.70102083 

    24/79 AceView cDNA sequences (see all 79):

    BC068457 AI375610 AW613042 AF363368 AI076878 BG911369 AI050793 AI991767 
    AI636231 CD516265 BE222930 BM931353 BX440536 NM_145296 BF002720 AI805103 
    BF508315 BE645821 AI143069 AI658865 AI768453 AI094791 AI934847 AI743967 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CADM4 expression in normal human tissues (normalized intensities)      CADM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTATATA
    CADM4 Expression
    About this image


    CADM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Peripheral Nervous System (Nervous System)
             Myelinating Schwann Cells Peripheral Nerve Domain
     
     Kidney (Urinary System)
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   
     
     Eye (Sensory Organs)
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells

    See CADM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CADM4

    SOURCE GeneReport for Unigene cluster: Hs.370984

    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs

        SABiosciences Custom PCR Arrays for CADM4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CADM4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CADM4 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm41 , 5 cell adhesion molecule 41, 5 90.46(n)1
    98.45(a)1
      7 (11.03 cM)5
    2602991  NM_153112.31  NP_694752.11 
     244820235 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.289762 Xenopus laevis transcribed sequence with weak similarity to protein refNP_055148.1 (H.sapiens) immunoglobulin superfamily, member 4 [Homo sapiens] less 76.14(n)    CD324788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadm41 cell adhesion molecule 4 62.7(n)
    60.58(a)
      492787  NM_001007428.1  NP_001007429.1 


    ENSEMBL Gene Tree for CADM4 (if available)
    TreeFam Gene Tree for CADM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CADM4 gene
    CADM32  CADM12  CRTAM2  CADM22  
    3 SIMAP similar genes for CADM4 using alignment to 1 protein entry:     CADM4_HUMAN:
    CADM1    CADM3    CADM2

    CADM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/345 SNPs in CADM4 are shown (see all 345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136855881,2
    C,F--44126043(+) TCACCG/ATGGAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs789960571,2
    C,F--44126091(+) GTTATT/GTTTTA 1 -- ds50012Minor allele frequency- G:0.07WA EA 238
    rs1140147711,2
    F--44126134(+) ATGAAT/CGAGAG 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1871643911,2
    C--44126227(+) ATTCAA/GAGTTC 1 -- ds50010--------
    rs346374721,2
    C,F,H--44126279(+) GGGTCC/TGGGCC 1 -- ds500121Minor allele frequency- T:0.23NS EA NA CSA WA 2348
    rs1153086441,2
    C,F--44126365(+) GTTTCT/CGGGGA 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs735565841,2
    C,F--44126389(+) TCAGTG/AAGGTC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs4332261,2
    C,F,A,H--44126738(+) ACCATA/GAAGAC 1 -- ut3128Minor allele frequency- G:0.26MN NS EA NA WA CSA 2951
    rs769249641,2
    C,F--44126955(+) AGTTAT/AGACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1489680981,2
    C--44127116(+) CCCTG-/CCCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CADM4 (44126520 - 44143991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CADM4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718611CNV Deletion23290073
    esv2670496CNV Deletion23128226
    nsv833839CNV Loss17160897
    esv23415CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CADM4
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609744    OMIM disorders: --

    3 diseases for CADM4:    About MalaCards
    renal clear cell carcinoma    colon cancer    prostatitis


    CADM4 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CADM4 (1 document)

    Export disorders for CADM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CADM4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CADM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)1, 2, 3, 9 Fukuhara H.... Murakami Y. (2001)
    2. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. (PubMed id 16261159)1, 2 Williams Y.N....Murakami Y. (2006)
    3. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (PubMed id 21544807)1 Nagata M....Murakami Y. (2012)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953)1 Karasik D....Demissie S. (2010)
    7. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PubMed id 19565570)1 Raveh S....Ben-Ze'ev A. (2009)
    8. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. (PubMed id 16825666)1 Giallourakis C....Xavier R. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199731 HGNC: 30825 AceView: IGSF4C Ensembl:ENSG00000105767 euGenes: HUgn199731
    ECgene: CADM4 H-InvDB: CADM4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CADM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CADM4 gene:
    Search GeneIP for patents involving CADM4

    Licensable Technologies for CADM4 gene:
    Weizmann Institute:Regulation of Myelination by Nectin-like molecules
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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