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Aliases for CADM4 Gene

Aliases for CADM4 Gene

  • Cell Adhesion Molecule 4 2 3
  • IGSF4C 3 4 6
  • NECL4 3 4 6
  • TSLL2 3 4 6
  • Immunoglobulin Superfamily, Member 4C 2 3
  • Immunoglobulin Superfamily Member 4C 3 4
  • Nectin-Like Protein 4 3 4
  • TSLC1-Like Protein 2 3 4
  • Nectin-Like 4 2 3
  • SynCAM4 3 6
  • Necl-4 3 4
  • TSLC1-Like 2 3

External Ids for CADM4 Gene

Previous Symbols for CADM4 Gene

  • IGSF4C

Summaries for CADM4 Gene

GeneCards Summary for CADM4 Gene

CADM4 (Cell Adhesion Molecule 4) is a Protein Coding gene. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot for CADM4 Gene

  • Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM4 Gene

Genomics for CADM4 Gene

Genomic Location for CADM4 Gene

Start:
43,622,367 bp from pter
End:
43,639,839 bp from pter
Size:
17,473 bases
Orientation:
Minus strand

Genomic View for CADM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CADM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM4 Gene

No data available for Regulatory Elements for CADM4 Gene

Proteins for CADM4 Gene

  • Protein details for CADM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ8-CADM4_HUMAN
    Recommended name:
    Cell adhesion molecule 4
    Protein Accession:
    Q8NFZ8
    Secondary Accessions:
    • B2R7L5
    • Q9Y4A4

    Protein attributes for CADM4 Gene

    Size:
    388 amino acids
    Molecular mass:
    42785 Da
    Quaternary structure:
    • Monomer and homodimer.
    SequenceCaution:
    • Sequence=AAC32740.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CADM4 Gene

Proteomics data for CADM4 Gene at MOPED

Post-translational modifications for CADM4 Gene

Other Protein References for CADM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CADM4 Gene

Domains for CADM4 Gene

Gene Families for CADM4 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

UniProtKB/Swiss-Prot:

CADM4_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q8NFZ8
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q8NFZ8
Family:
  • Belongs to the nectin family.:
    • Q8NFZ8
genes like me logo Genes that share domains with CADM4: view

Function for CADM4 Gene

Molecular function for CADM4 Gene

UniProtKB/Swiss-Prot Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

Gene Ontology (GO) - Molecular Function for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CADM4: view
genes like me logo Genes that share phenotypes with CADM4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CADM4 Gene

Localization for CADM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADM4 Gene COMPARTMENTS Subcellular localization image for CADM4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CADM4: view

Pathways for CADM4 Gene

SuperPathways for CADM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CADM4: view

No data available for Pathways by source for CADM4 Gene

Compounds for CADM4 Gene

(2) HMDB Compounds for CADM4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with CADM4: view

Transcripts for CADM4 Gene

mRNA/cDNA for CADM4 Gene

Unigene Clusters for CADM4 Gene

Cell adhesion molecule 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CADM4 Gene

No ASD Table

Relevant External Links for CADM4 Gene

GeneLoc Exon Structure for
CADM4
ECgene alternative splicing isoforms for
CADM4

Expression for CADM4 Gene

mRNA expression in normal human tissues for CADM4 Gene

mRNA differential expression in normal tissues according to GTEx for CADM4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.8) and Nerve - Tibial (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CADM4 Gene

SOURCE GeneReport for Unigene cluster for CADM4 Gene Hs.370984

mRNA Expression by UniProt/SwissProt for CADM4 Gene

Q8NFZ8-CADM4_HUMAN
Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs.
genes like me logo Genes that share expressions with CADM4: view

Orthologs for CADM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM4 36
  • 99.55 (n)
  • 99.46 (a)
CADM4 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CADM4 36
  • 92.18 (n)
  • 97.84 (a)
CADM4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CADM4 36
  • 92.14 (n)
  • 99.19 (a)
CADM4 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadm4 36
  • 90.46 (n)
  • 98.45 (a)
Cadm4 16
Cadm4 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CADM4 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CADM4 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadm4 36
  • 89.86 (n)
  • 98.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28976 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488420 36
  • 68.5 (n)
  • 73.83 (a)
Str.15421 36
zebrafish
(Danio rerio)
Actinopterygii cadm4 36
  • 63.36 (n)
  • 61.71 (a)
cadm4 37
  • 54 (a)
OneToOne
Species with no ortholog for CADM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM4 Gene

ENSEMBL:
Gene Tree for CADM4 (if available)
TreeFam:
Gene Tree for CADM4 (if available)

Paralogs for CADM4 Gene

Paralogs for CADM4 Gene

Selected SIMAP similar genes for CADM4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CADM4: view

Variants for CADM4 Gene

Sequence variations from dbSNP and Humsavar for CADM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs400058 -- 43,636,863(+) CCCCC(C/T)ATTCT intron-variant
rs407049 -- 43,627,145(+) GCGTC(C/T)GACAA intron-variant
rs413176 -- 43,633,701(+) tttga(A/G)ataag intron-variant
rs433226 -- 43,622,586(+) ACCAT(A/G)AAGAC utr-variant-3-prime
rs1879387 -- 43,623,109(-) GGGCA(C/G)GGGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CADM4 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
esv2718611 CNV Deletion 23290073
esv2670496 CNV Deletion 23128226
esv23415 CNV Gain 19812545

Relevant External Links for CADM4 Gene

HapMap Linkage Disequilibrium report
CADM4

Disorders for CADM4 Gene

Relevant External Links for CADM4

Human Genome Epidemiology (HuGE) Navigator
CADM4
genes like me logo Genes that share disorders with CADM4: view

No data available for UniProtKB/Swiss-Prot for CADM4 Gene

Publications for CADM4 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H. … Murakami Y. (Oncogene 2001) 2 3 4 23
  2. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. (PMID: 16261159) Williams Y.N. … Murakami Y. (Oncogene 2006) 3 4
  3. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. (PMID: 16825666) Giallourakis C. … Xavier R. (Genome Res. 2006) 3
  4. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PMID: 19565570) Raveh S. … Ben-Ze'ev A. (J. Cell. Biochem. 2009) 3
  5. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PMID: 20200953) Karasik D. … Demissie S. (J. Bone Miner. Res. 2010) 3

Products for CADM4 Gene

Sources for CADM4 Gene

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