Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CADM4 Gene

protein-coding   GIFtS: 56
GCID: GC19M044126

Cell Adhesion Molecule 4

(Previous names: immunoglobulin superfamily, member 4C)
(Previous symbol: IGSF4C)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cell Adhesion Molecule 41 2     TSLC1-Like Protein 22 3
IGSF4C1 2 3 5     Necl-42
NECL42 3 5     synCAM42
TSLL22 3 5     TSLC1-Like 22
Immunoglobulin Superfamily, Member 4C1 2     IgSF4C3
Nectin-Like 41 2     NECL-43
Immunoglobulin Superfamily Member 4C2 3     SYNCAM45
Nectin-Like Protein 42 3     

External Ids:    HGNC: 308251   Entrez Gene: 1997312   Ensembl: ENSG000001057677   OMIM: 6097445   UniProtKB: Q8NFZ83   

Export aliases for CADM4 gene to outside databases

Previous GC identifers: GC19M048821 GC19M040557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CADM4 Gene:
CADM4 (cell adhesion molecule 4) is a protein-coding gene. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity.
May have tumor-suppressor activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CADM4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CADM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

CADM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044126:  view genomic region     (about GC identifiers)

Start:
44,126,520 bp from pter      End:
44,143,991 bp from pter
Size:
17,472 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8 (See protein sequence)
Recommended Name: Cell adhesion molecule 4 precursor  
Size: 388 amino acids; 42785 Da
Subunit: Monomer and homodimer
Sequence caution: Sequence=AAC32740.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R7L5 Q9Y4A4

Explore the universe of human proteins at neXtProt for CADM4: NX_Q8NFZ8

Explore proteomics data for CADM4 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn31, Asn67, Asn286
  • Modification sites at PhosphoSitePlus

  • See CADM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660339.1  
    ENSEMBL proteins: 
     ENSP00000222374  

    CADM4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM4 (IGSF4C/SynCAM4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CADM4
    OriGene Protein Over-expression Lysate for CADM4
    OriGene MassSpec for CADM4
    OriGene Custom Protein Services for CADM4
    GenScript Custom Purified and Recombinant Proteins Services for CADM4
    Novus Biologicals CADM4 Lysate
    Sino Biological Recombinant Protein for CADM4
    Sino Biological Cell Lysate for CADM4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM4

     
    Search eBioscience for Proteins for CADM4 

    CADM4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CADM4 (IGSF4C/SynCAM4)
    OriGene Antibodies for CADM4
    OriGene Custom Antibody Services for CADM4
    Novus Biologicals CADM4 Antibodies
    Abcam antibodies for CADM4
    Cloud-Clone Corp. Antibodies for CADM4
    ThermoFisher Antibodies for CADM4
    LSBio Antibodies in human, mouse, rat for CADM4

    CADM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CADM4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CADM4
    Cloud-Clone Corp. CLIAs for CADM4
    Search eBioscience for ELISAs for CADM4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR028807 Cadm

    Graphical View of Domain Structure for InterPro Entry Q8NFZ8

    ProtoNet protein and cluster: Q8NFZ8

    Selected Blocks protein domains (see all 6):
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CADM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM4_HUMAN, Q8NFZ8
    Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity.
    May have tumor-suppressor activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CADM4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CADM4:
     Decreased cell number  Increased circadian period len  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cadm4):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with CADM4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CADM4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CADM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADM4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CADM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCADM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CADM4
    Predesigned siRNA for gene silencing in human, mouse, rat CADM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CADM4

    Clone
    Products:
         
    OriGene clones in human, mouse for CADM4 (see all 5)
    OriGene ORF clones in mouse, rat for CADM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    Sino Biological Human cDNA Clone for CADM4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CADM4
    Browse ESI BIO Cell Lines and PureStem Progenitors for CADM4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CADM4_HUMAN, Q8NFZ8: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CADM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CADM4
    Interactions:

        Search GeneGlobe Interaction Network for CADM4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CADM4 (Q8NFZ82, 3 ENSP000002223744) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496742, 3MINT-8252714 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254833 I2D: score=2 
    CNKSR1Q969H43, ENSP000003546094I2D: score=1 STRING: ENSP00000354609
    PDGFRAENSP000002572904STRING: ENSP00000257290
    CADM3ENSP000003571064STRING: ENSP00000357106
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with CADM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CADM4

    2 HMDB Compounds for CADM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CADM4 gene: 
    NM_145296.1  

    Unigene Cluster for CADM4:

    Cell adhesion molecule 4
    Hs.370984  [show with all ESTs]
    Unigene Representative Sequence: NM_145296
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222374(uc002oxc.1) ENST00000593506
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CADM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM4 (see all 51):
    hsa-miR-194* hsa-miR-4254 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-631 hsa-miR-218-1* hsa-miR-3678-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCADM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CADM4
    Predesigned siRNA for gene silencing in human, mouse, rat CADM4
    Clone
    Products:
         
    OriGene clones in human, mouse for CADM4 (see all 5)
    OriGene ORF clones in mouse, rat for CADM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CADM4 (NM_145296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CADM4
    OriGene qSTAR qPCR primer pairs in human, mouse for CADM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM4
      QuantiTect SYBR Green Assays in human, mouse, rat CADM4
      QuantiFast Probe-based Assays in human, mouse, rat CADM4

    Additional mRNA sequence: 

    AF363368.1 AK313028.1 BC068457.1 BC113963.1 

    6 DOTS entries:

    DT.205521  DT.400116  DT.40126806  DT.91642811  DT.92418719  DT.70102083 

    Selected AceView cDNA sequences (see all 79):

    BX440536 BM931353 BG911369 AI991767 AW613042 BF002720 BE222930 AI636231 
    NM_145296 BC068457 AF363368 AI076878 CD516265 AI375610 BF508315 AI050793 
    AI805103 AI869487 AI143069 AW992019 AI768453 BX463698 AA985225 BM674356 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CADM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTATATA
    CADM4 Expression
    About this image


    CADM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Peripheral Nervous System (Nervous System)
             Myelinating Schwann Cells Peripheral Nerve Domain
     
     Brain (Nervous System)
             Cerebral Cortex
    CADM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CADM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370984

    UniProtKB/Swiss-Prot: CADM4_HUMAN, Q8NFZ8
    Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs

        Custom PCR Arrays for CADM4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CADM4
    OriGene qSTAR qPCR primer pairs in human, mouse for CADM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM4
    QuantiTect SYBR Green Assays in human, mouse, rat CADM4
    QuantiFast Probe-based Assays in human, mouse, rat CADM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CADM4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm41 , 5 cell adhesion molecule 41, 5 90.46(n)1
    98.45(a)1
      7 (11.03 cM)5
    2602991  NM_153112.31  NP_694752.11 
     244820235 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.289762 Xenopus laevis transcribed sequence with weak similarity more 76.14(n)    CD324788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadm41 cell adhesion molecule 4 63.36(n)
    61.71(a)
      492787  NM_001007428.1  NP_001007429.1 


    ENSEMBL Gene Tree for CADM4 (if available)
    TreeFam Gene Tree for CADM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CADM4 gene
    CADM32  CADM12  CRTAM2  CADM22  
    3 SIMAP similar genes for CADM4 using alignment to 1 protein entry:     CADM4_HUMAN:
    CADM1    CADM3    CADM2

    Find genes that share paralogs with CADM4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CADM4 (see all 345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136855881,2
    C,F--44126043(+) TCACCG/ATGGAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs789960571,2
    C,F--44126091(+) GTTATT/GTTTTA 1 -- ds50012Minor allele frequency- G:0.07WA EA 238
    rs1140147711,2
    F--44126134(+) ATGAAT/CGAGAG 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1871643911,2
    C--44126227(+) ATTCAA/GAGTTC 1 -- ds50010--------
    rs346374721,2
    C,F,H--44126279(+) GGGTCC/TGGGCC 1 -- ds500121Minor allele frequency- T:0.23NS EA NA CSA WA 2348
    rs1153086441,2
    C,F--44126365(+) GTTTCT/CGGGGA 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs735565841,2
    C,F--44126389(+) TCAGTG/AAGGTC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs4332261,2
    C,F,A,H--44126738(+) ACCATA/GAAGAC 1 -- ut3128Minor allele frequency- G:0.26MN NS EA NA WA CSA 2951
    rs769249641,2
    C,F--44126955(+) AGTTAT/AGACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1489680981,2
    C--44127116(+) CCCTG-/CCCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CADM4 (44126520 - 44143991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CADM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718611CNV Deletion23290073
    esv2670496CNV Deletion23128226
    nsv833839CNV Loss17160897
    esv23415CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CADM4
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609744    OMIM disorders: --


    Find genes that share disorders with CADM4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CADM4 (1 document)

    Export disorders for CADM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CADM4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CADM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)1, 2, 3, 9 Fukuhara H.... Murakami Y. (Oncogene 2001)
    2. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. (PubMed id 16261159)1, 2 Williams Y.N....Murakami Y. (Oncogene 2006)
    3. Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast. (PubMed id 23559354)1 Jang S.M....Paik S.S. (J. Clin. Pathol. 2013)
    4. Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy. (PubMed id 23825401)1 Golan N....Peles E. (J. Neurosci. 2013)
    5. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (PubMed id 21544807)1 Nagata M....Murakami Y. (Int. J. Cancer 2012)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PubMed id 20200953)1 Karasik D....Demissie S. (J. Bone Miner. Res. 2010)
    9. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PubMed id 19565570)1 Raveh S....Ben-Ze'ev A. (J. Cell. Biochem. 2009)
    10. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. (PubMed id 16825666)1 Giallourakis C....Xavier R. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 199731 HGNC: 30825 AceView: IGSF4C Ensembl:ENSG00000105767 euGenes: HUgn199731
    ECgene: CADM4 H-InvDB: CADM4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CADM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CADM4 gene:
    Search GeneIP for patents involving CADM4

    Licensable Technologies for CADM4 gene:
    Weizmann Institute:Regulation of Myelination by Nectin-like molecules
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CADM4 (IGSF4C/SynCAM4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CADM4 (IGSF4C/SynCAM4)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CADM4   OriGene RNAi products in human, mouse, rat for CADM4  
     OriGene qPCR primer pairs and template standards for CADM4   OriGene Protein Over-expression Lysate for CADM4  
     OriGene MassSpec something-or-other for CADM4   OriGene clones in human, mouse for CADM4  
     OriGene qSTAR qPCR primer pairs in human, mouse for CADM4   OriGene Purified Protein for CADM4  
     OriGene ORF clones in mouse, rat for CADM4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CADM4   OriGene Custom Protein Services for CADM4  

     
     
     Block miRNA regulation of human, mouse, rat CADM4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CADM4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADM4 Predesigned siRNA for gene silencing in human, mouse, rat CADM4
     QuantiFast Probe-based Assays in human, mouse, rat CADM4 QuantiTect SYBR Green Assays in human, mouse, rat CADM4
     Custom PCR Arrays for CADM4 Search Chromatin IP Primers for CADM4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM4  Search GeneGlobe Interaction Network for CADM4
     Search Regulatory tfbs for CADM4
     GenScript Custom Purified and Recombinant Proteins Services for CADM4 GenScript cDNA clones with any tag delivered in your preferred vector for CADM4
     GenScript Custom Assay Services for CADM4 GenScript Custom overexpressing Cell Line Services for CADM4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CADM4
     Proteins for CADM4
     Cell Lysates for CADM4
     cDNA Clones for CADM4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CADM4 antibodies
     CADM4 lysates
     Antibodies for CADM4
     See all of Abcam's Antibodies, Kits and Proteins for CADM4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CADM4
     Antibodies for CADM4
     ELISAs for CADM4
     CLIAs for CADM4



     Browse ESI BIO Cell Lines and PureStem Progenitors for CADM4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM4
     SwitchGear 3'UTR luciferase reporter plasmids for CADM4
     Browse SwitchGear Promoter luciferase reporter plasmids for CADM4
     ThermoFisher Antibodies for CADM4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CADM4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CADM4
     LSBio Antibodies in human, mouse, rat for CADM4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CADM4
      Search eBioscience for proteins for CADM4
      Search eBioscience for elisas for CADM4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CADM4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4