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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CADM3 Gene

protein-coding   GIFtS: 61
GCID: GC01P159141

Cell Adhesion Molecule 3

(Previous names: immunoglobulin superfamily, member 4B)
(Previous symbol: IGSF4B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Adhesion Molecule 31 2     TSLC1-Like Protein 12 3
IGSF4B1 2 3 5     SYNCAM33 5
NECL12 3 5     BIgR2
TSLL12 3 5     Necl-12
Immunoglobulin Superfamily, Member 4B1 2     Dendritic Cell Nectin-Like Protein 1 Short Isoform2
Nectin-Like 11 2     synCAM32
Brain Immunoglobulin Receptor2 3     TSLC1-Like 12
Immunoglobulin Superfamily Member 4B2 3     IgSF4B3
Nectin-Like Protein 12 3     NECL-13
Synaptic Cell Adhesion Molecule 32 3     SynCAM33

External Ids:    HGNC: 176011   Entrez Gene: 578632   Ensembl: ENSG000001627067   OMIM: 6097435   UniProtKB: Q8N1263   

Export aliases for CADM3 gene to outside databases

Previous GC identifers: GC01P157410 GC01P157411 GC01P130498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CADM3 Gene:
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as
nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 (PubMed 15741237)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CADM3 Gene: 
CADM3 (cell adhesion molecule 3) is a protein-coding gene. Diseases associated with CADM3 include herpes simplex, and schizophrenia, and among its related super-pathways are Cell-cell junction organization. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity
and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with
EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)

Gene Wiki entry for CADM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CADM3 gene promoter:
         NRSF form 1   Tal-1beta   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCADM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CADM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21.2-q22

CADM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159141:  view genomic region     (about GC identifiers)

Start:
159,141,377 bp from pter      End:
159,173,103 bp from pter
Size:
31,727 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126 (See protein sequence)
Recommended Name: Cell adhesion molecule 3 precursor  
Size: 398 amino acids; 43300 Da
Subunit: Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK
(By similarity)
Subcellular location: Cell junction (By similarity). Cell membrane; Single-pass type I membrane protein (By
similarity). Note=Localized at the cell-cell attached sites of the plasma membrane (By similarity)
Sequence caution: Sequence=BAA91756.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CADM3:
1Z9M (3D)    
Secondary accessions: Q8IZQ9 Q9NVJ5 Q9UJP1
Alternative splicing: 3 isoforms:  Q8N126-1   Q8N126-2   Q8N126-3   

Explore the universe of human proteins at neXtProt for CADM3: NX_Q8N126

Explore proteomics data for CADM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N126

  • CADM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CADM3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120645.1  NP_067012.1  

    ENSEMBL proteins: 
     ENSP00000357106   ENSP00000357107   ENSP00000387802  
    Reactome Protein details: Q8N126
    Human Recombinant Protein Products for CADM3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM3 (IGSF4B/SynCAM3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CADM3
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    Sino Biological Recombinant Protein for CADM3
    Sino Biological Cell Lysate for CADM3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ISS12826663
    GO:0016021integral to membrane IEA--

    CADM3 for ontologies           About GeneDecksing



    CADM3 Antibody Products: 
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    Novus Biologicals CADM3 Antibodies
    Abcam antibodies for CADM3
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    LSBio Antibodies in human, mouse, rat for CADM3 

    Assay Products for CADM3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CADM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N126

    ProtoNet protein and cluster: Q8N126

    4 Blocks protein domains:
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
    Domain: The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK (By similarity)
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CADM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM3_HUMAN, Q8N126
    Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity
    and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with
    EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)
    Induction: Markedly in glioma cell lines and prostate cancer cell lines

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS12826663
         
    CADM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CADM3:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cadm3):
     nervous system 

    CADM3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CADM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CADM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADM3 

    miRNA
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    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM3 (see all 59):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3678-5p hsa-let-7a-2* hsa-miR-632 hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmidCADM3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CADM3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Adherens junctions interactions0.51
    2Nectin/Necl trans heterodimerization
    Nectin/Necl trans heterodimerization
    3Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5        Reactome Pathways for CADM3
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    1         Kegg Pathway  (Kegg details for CADM3):
        Cell adhesion molecules (CAMs)


    CADM3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CADM3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for CADM3 (Q8N1263 ENSP000003571064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCHP247233I2D: score=2 
    KCNMA1Q127913I2D: score=1 
    MPP6Q9NZW53I2D: score=1 
    CADM1ENSP000003297974STRING: ENSP00000329797
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS12826663
    GO:0007157heterophilic cell-cell adhesion ISS12826663
    GO:0008104protein localization IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--

    CADM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CADM3

    1 HMDB Compound for CADM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CADM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CADM3 gene (2 alternative transcripts): 
    NM_001127173.1  NM_021189.3  

    Unigene Cluster for CADM3:

    Cell adhesion molecule 3
    Hs.365689  [show with all ESTs]
    Unigene Representative Sequence: NM_021189
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368124(uc009wsx.1 uc009wsy.1) ENST00000368125(uc001ftk.2 uc001ftl.2)
    ENST00000416746 ENST00000497636
    miRNA
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    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM3 (see all 59):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3678-5p hsa-let-7a-2* hsa-miR-632 hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmidCADM3 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM3
    Sirion Biotech Customized lentivirus for stable overexpression of CADM3 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM3

    Additional mRNA sequence: 

    AF062733.2 AF363367.1 AF529206.1 AK001560.1 AK289541.1 AK308915.1 AY046418.1 AY358332.1 
    BC033819.1 

    6 DOTS entries:

    DT.421927  DT.100690853  DT.91758992  DT.100024622  DT.121397019  DT.102831425 

    24/264 AceView cDNA sequences (see all 264):

    AF363367 CD673597 AI955148 BQ640233 BX281058 BM708988 AW296169 AI094929 
    AU150243 BU739599 BM708111 BM704393 CD676370 BE467284 BE502006 BM722566 
    BU150151 AI318397 CR605082 BM972973 BQ898419 AI342121 BM671230 N47613 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:              -     -     -     -                                   -                       -                     
    SP2:              -     -     -     -     -     -                       -                       -                     
    SP3:                                                                                                                  
    SP4:              -     -     -     -     -     -                                                                     
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for CADM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CADM3 expression in normal human tissues (normalized intensities)      CADM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTGCTCA
    CADM3 Expression
    About this image


    CADM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
             dorsal root ganglia   
     
     Fibroblast
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See CADM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CADM3

    SOURCE GeneReport for Unigene cluster: Hs.365689

    UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
    Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult
    brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CADM3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm31 , 5 cell adhesion molecule 31, 5 89.48(n)1
    95.2(a)1
      1 (80.33 cM)5
    943321  NM_053199.31  NP_444429.11 
     1733342545 
    chicken
    (Gallus gallus)
    Aves LOC7723561 cell adhesion molecule 3-like 68.66(n)
    68.53(a)
      772356  XM_001235504.2  XP_001235505.2 
    lizard
    (Anolis carolinensis)
    Reptilia CADM36
    --
    Uncharacterized protein
    60(a)
    60(a)
    1 ↔ 1
    possible ortholog
    GL344307.1(746-7201)
    GL345054.1(1323-10654)
    African clawed frog
    (Xenopus laevis)
    Amphibia necl1-pending-prov2 nectin-lke 1 75.23(n)    BC044084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadm31 cell adhesion molecule 3 59.58(n)
    56.95(a)
      692273  NM_001045246.1  NP_001038711.1 


    ENSEMBL Gene Tree for CADM3 (if available)
    TreeFam Gene Tree for CADM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CADM3 gene
    CADM42  CADM12  CRTAM2  CADM22  
    4 SIMAP similar genes for CADM3 using alignment to 1 protein entry:     CADM3_HUMAN:
    GYPC    CADM2    CADM4    CADM1

    CADM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/459 SNPs in CADM3 are shown (see all 459)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160383601,2
    F--159139742(+) TACTGG/CTAACC 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1404039911,2
    --159139771(+) TGCCCA/GTGAGT 2 -- us2k10--------
    rs1846105091,2
    --159139866(+) ATTAGC/TCCAGT 2 -- us2k10--------
    rs1894455931,2
    --159140001(+) CACATC/TCCAGC 2 -- us2k10--------
    rs780402231,2
    F--159140017(+) CTTGTG/ATCTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1497050091,2
    --159140069(+) TTTGAA/GCCTCA 2 -- us2k10--------
    rs1454555761,2
    --159140085(+) ACCTAG/TATAAT 2 -- us2k10--------
    rs1163837441,2
    C,F--159140240(+) GACTCG/AGAGAT 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs9653581,2
    C,F,O,A,H--159140349(+) CAGGAA/TTGACA 2 -- us2k1 tfbs3121Minor allele frequency- T:0.28NS MN EA NA PA EU CA WA CSA 9146
    rs9653591,2
    C,F,O,H--159140376(+) ACGCAG/AGGGTC 2 -- us2k122Minor allele frequency- A:0.07NA EA MN NS WA 4036

    HapMap Linkage Disequilibrium report for CADM3 (159141377 - 159173103 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CADM3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CADM3
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609743    OMIM disorders: --

    7 diseases for CADM3:    About MalaCards
    herpes simplex    schizophrenia    hepatitis b    colon cancer
    hepatitis    prostate cancer    prostatitis


    CADM3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CADM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.28 4 19565570 (2), 14659875 (1), 11536053 (1)
    cancer 0 2 14659875 (1), 11536053 (1)

    Genetic Association Database (GAD): CADM3
    Human Genome Epidemiology (HuGE) Navigator: CADM3 (1 document)

    Export disorders for CADM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CADM3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CADM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)1, 2, 3, 9 Fukuhara H.... Murakami Y. (2001)
    2. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PubMed id 15893517)1, 2, 9 Zhou Y.... Yuan J. (2005)
    3. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PubMed id 16467305)1, 2, 9 Dong X.... Rao Z. (2006)
    4. A genome-wide association scan on the levels of marker s of inflammation in Sardinians reveals associations that underpin its complex r egulation. (PubMed id 22291609)1, 4 Naitza S....Cucca F. (2012)
    5. Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. (PubMed id 18420026)1, 2 Gao J....Peng X. (2008)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57863 HGNC: 17601 AceView: FYandIGSF4B Ensembl:ENSG00000162706 euGenes: HUgn57863
    ECgene: CADM3 Kegg: 57863 H-InvDB: CADM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CADM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CADM3 gene:
    Search GeneIP for patents involving CADM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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