CADM3 Gene

Aliases
for CADM3 gene

Previous GC identifers: GC01P157410 GC01P157411 GC01P130498

Summaries
for CADM3 gene

Genomic Views
for CADM3 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmid: CADM3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM3

CADM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159141:  view genomic region     (about GC identifiers)

Proteins
for CADM3 gene

1 PDB 3D structure from and Proteopedia for CADM3:

1Z9M (3D)    

Explore the universe of human proteins at neXtProt for CADM3: NX_Q8N126

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CADM3 (IGSF4B/SynCAM3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CADM3 OriGene Custom Protein Services for CADM3
	GenScript Custom Purified and Recombinant Proteins Services for CADM3
	Sino Biological Recombinant Protein for CADM3
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CADM3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CADM3
	R&D Systems Antibodies for CADM3 (IGSF4B/SynCAM3)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CADM3
	GenScript Custom Superior Antibodies Services for CADM3
	Novus Biologicals CADM3 Antibodies
	Search for Antibodies for CADM3 at Abcam
	Uscn Antibodies for CADM3
	Search ThermoFisher Antibodies for CADM3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CADM3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CADM3

Protein Domains /
Families
for CADM3 gene

ProtoNet protein and cluster: Q8N126

Function
for CADM3 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CADM3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM3
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM3 (see all 59):
		hsa-miR-142-5p hsa-miR-140-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3678-5p hsa-let-7a-2* hsa-miR-632 hsa-miR-346
		SwitchGear 3'UTR luciferase reporter plasmid: CADM3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM3 (see all 7) OriGene shRNA RFP: CADM3 OriGene siRNA: CADM3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CADM3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CADM3 (NM_021189)
		Sino Biological Human cDNA Clone for CADM3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CADM3
		Search LifeMap BioReagents cell lines for CADM3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cadm3)

Pathways & Interactions
for CADM3 gene

	Super-pathway	contained gene-specific pathways
1	Cell-cell junction organization	Cell-cell junction organization 1.00 Adherens junctions interactions 0.51 Cell junction organization 0.69 Cell-Cell communication 0.45
2	Nectin/Necl trans heterodimerization	Nectin/Necl trans heterodimerization 1.00
3	Cell adhesion molecules (CAMs)	Cell adhesion molecules (CAMs) 1.00

5        Reactome Pathways for CADM3

	Adherens junctions interactions
	Nectin/Necl trans heterodimerization
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

1         Kegg Pathway  (Kegg details for CADM3)

Cell adhesion molecules (CAMs)

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for CADM3 gene

Transcripts
for CADM3 gene

Expression
for CADM3 gene

CADM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCATTGCTCA

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Neural TubeNeural TubeSpinal Neural Tube Cells			Neural Ectoderm
	EyeRetina			Eye
	Spinal CordPresumptive Spinal Cord			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CADM3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CADM3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3

Orthologs
for CADM3 gene

Paralogs
for CADM3 gene

Paralogs for CADM3 gene

CADM4²  PVR²  CRTAM²  CADM1²  PVRL4²  PVRL3²  PVRL2²  CADM2²  

PVRL1²  

4 SIMAP similar genes for CADM3 using alignment to 1 protein entry:     CADM3_HUMAN:

GYPC    CADM2    CADM4    CADM1

CADM3 for paralogs           About GeneDecksing

Genomic Variants
for CADM3 gene

10/529 NCBI SNPs in CADM3 are shown (see all 529)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1160383601,2		--	159139742(+)	TACTGG/CTAACC	2	--	us2k1		1		NA	120
rs1404039911,2		--	159139771(+)	TGCCCA/GTGAGT	2	--	us2k1		0	--	--	--	--
rs1846105091,2		--	159139866(+)	ATTAGC/TCCAGT	2	--	us2k1		0	--	--	--	--
rs1894455931,2		--	159140001(+)	CACATC/TCCAGC	2	--	us2k1		0	--	--	--	--
rs780402231,2	F,	--	159140017(+)	CTTGTG/ATCTTC	2	--	us2k1		1		WA	118
rs1497050091,2		--	159140069(+)	TTTGAA/GCCTCA	2	--	us2k1		0	--	--	--	--
rs1454555761,2		--	159140085(+)	ACCTAG/TATAAT	2	--	us2k1		0	--	--	--	--
rs1163837441,2		--	159140240(+)	GACTCG/AGAGAT	2	--	us2k1		1		NA	120
rs9653581,2	C,F,O,A,H,	--	159140349(+)	CAGGAA/TTGACA	2	--	us2k1 tfbs3		121		NS MN EA NA PA EU CA WA CSA	9146
rs9653591,2	C,F,O,H,	--	159140376(+)	ACGCAG/AGGGTC	2	--	us2k1		22		NA EA MN NS WA	4036

HapMap Linkage Disequilibrium report for CADM3 (159141377 - 159173103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CADM3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CADM3

DNA2.0 Custom Variant and Variant Library Synthesis for CADM3

Disorders / Diseases
for CADM3 gene

7 diseases for CADM3

2 Novoseek disease relationships for CADM3 gene    About this table

Publications
for CADM3 gene

PubMed articles for CADM3 gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with CADM3)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)^{1, 2, 3, 9} Fukuhara H.... Murakami Y. (2001)
2. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PubMed id 15893517)^{1, 2, 9} Zhou Y.... Yuan J. (2005)
3. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PubMed id 16467305)^{1, 2, 9} Dong X.... Rao Z. (2006)
4. Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. (PubMed id 18420026)^{1, 2} Gao J....Peng X. (2008)
5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
9. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). (PubMed id 14659875)^{1, 9} Fukami T....Murakami Y. (2003)
10. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PubMed id 19565570)^{1, 9} Raveh S....Ben-Ze'ev A. (2009)

External Searches for CADM3 gene

Genome Databases showing CADM3 gene

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Specialized Databases showing CADM3 gene

Products
for CADM3 gene