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CADM3 Gene

protein-coding   GIFtS: 61
GCID: GC01P159141

Cell Adhesion Molecule 3

(Previous names: immunoglobulin superfamily, member 4B)
(Previous symbol: IGSF4B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Adhesion Molecule 31 2     TSLC1-Like Protein 12 3
IGSF4B1 2 3 5     SYNCAM33 5
NECL12 3 5     BIgR2
TSLL12 3 5     Necl-12
Immunoglobulin Superfamily, Member 4B1 2     Dendritic Cell Nectin-Like Protein 1 Short Isoform2
Nectin-Like 11 2     synCAM32
Brain Immunoglobulin Receptor2 3     TSLC1-Like 12
Immunoglobulin Superfamily Member 4B2 3     IgSF4B3
Nectin-Like Protein 12 3     NECL-13
Synaptic Cell Adhesion Molecule 32 3     SynCAM33

External Ids:    HGNC: 176011   Entrez Gene: 578632   Ensembl: ENSG000001627067   OMIM: 6097435   UniProtKB: Q8N1263   

Export aliases for CADM3 gene to outside databases

Previous GC identifers: GC01P157410 GC01P157411 GC01P130498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CADM3 Gene:
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as
nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 (PubMed 15741237)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CADM3 Gene:
CADM3 (cell adhesion molecule 3) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity
and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with
EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)

Gene Wiki entry for CADM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CADM3 gene promoter:
         NRSF form 1   Tal-1beta   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCADM3 promoter sequence
   Search Chromatin IP Primers for CADM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21.2-q22

CADM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159141:  view genomic region     (about GC identifiers)

Start:
159,141,377 bp from pter      End:
159,173,103 bp from pter
Size:
31,727 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126 (See protein sequence)
Recommended Name: Cell adhesion molecule 3 precursor  
Size: 398 amino acids; 43300 Da
Subunit: Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK
(By similarity)
Sequence caution: Sequence=BAA91756.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CADM3:
1Z9M (3D)    
Secondary accessions: Q8IZQ9 Q9NVJ5 Q9UJP1
Alternative splicing: 3 isoforms:  Q8N126-1   Q8N126-2   Q8N126-3   

Explore the universe of human proteins at neXtProt for CADM3: NX_Q8N126

Explore proteomics data for CADM3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn290
  • Modification sites at PhosphoSitePlus

  • See CADM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120645.1  NP_067012.1  

    ENSEMBL proteins: 
     ENSP00000357106   ENSP00000357107   ENSP00000387802  
    Reactome Protein details: Q8N126

    CADM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM3 (IGSF4B/SynCAM3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CADM3
    OriGene Protein Over-expression Lysate for CADM3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CADM3
    GenScript Custom Purified and Recombinant Proteins Services for CADM3
    Sino Biological Recombinant Protein for CADM3
    Sino Biological Cell Lysate for CADM3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM3

     
    Search eBioscience for Proteins for CADM3 

    CADM3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CADM3
    R&D Systems Antibodies for CADM3 (IGSF4B/SynCAM3)
    OriGene Antibodies for CADM3
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    Novus Biologicals CADM3 Antibodies
    Abcam antibodies for CADM3
    Cloud-Clone Corp. Antibodies for CADM3
    Search ThermoFisher Antibodies for CADM3
    LSBio Antibodies in human, mouse, rat for CADM3

    CADM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CADM3
    Cloud-Clone Corp. CLIAs for CADM3
    Search eBioscience for ELISAs for CADM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR028807 Cadm

    Graphical View of Domain Structure for InterPro Entry Q8N126

    ProtoNet protein and cluster: Q8N126

    4 Blocks protein domains:
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
    Domain: The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK (By similarity)
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CADM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM3_HUMAN, Q8N126
    Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity
    and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with
    EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)
    Induction: Markedly in glioma cell lines and prostate cancer cell lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS12826663
         
    Find genes that share ontologies with CADM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CADM3:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Cadm3):
     nervous system 

    Find genes that share phenotypes with CADM3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CADM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CADM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADM3

    miRNA
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    Block miRNA regulation of human, mouse, rat CADM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM3 (see all 59):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3678-5p hsa-let-7a-2* hsa-miR-632 hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmidCADM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CADM3
    Predesigned siRNA for gene silencing in human, mouse, rat CADM3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CADM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM3 (NM_021189)
    Sino Biological Human cDNA Clone for CADM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CADM3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADM3_HUMAN, Q8N126: Cell junction (By similarity). Cell membrane; Single-pass type I membrane protein (By
    similarity). Note=Localized at the cell-cell attached sites of the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ISS12826663
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CADM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CADM3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Adherens junctions interactions0.49
    Cell-cell junction organization0.70
    Nectin/Necl trans heterodimerization0.00
    Cell-Cell communication0.64
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with CADM3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CADM3
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization


    1 Kegg Pathway  (Kegg details for CADM3):
        Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CADM3
    Interactions:

        Search GeneGlobe Interaction Network for CADM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CADM3 (Q8N1263 ENSP000003571064) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCHP247233I2D: score=2 
    KCNMA1Q127913I2D: score=1 
    MPP6Q9NZW53I2D: score=1 
    CADM1ENSP000003297974STRING: ENSP00000329797
    IGHEENSP000003749834STRING: ENSP00000374983
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS12826663
    GO:0007157heterophilic cell-cell adhesion ISS12826663
    GO:0008104protein localization IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--

    Find genes that share ontologies with CADM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CADM3

    1 HMDB Compound for CADM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CADM3 gene (2 alternative transcripts): 
    NM_001127173.1  NM_021189.3  

    Unigene Cluster for CADM3:

    Cell adhesion molecule 3
    Hs.365689  [show with all ESTs]
    Unigene Representative Sequence: NM_021189
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368124(uc009wsx.1 uc009wsy.1) ENST00000368125(uc001ftk.2 uc001ftl.2)
    ENST00000416746 ENST00000497636
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CADM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM3 (see all 59):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-3938 hsa-miR-1321 hsa-miR-3678-5p hsa-let-7a-2* hsa-miR-632 hsa-miR-346
    SwitchGear 3'UTR luciferase reporter plasmidCADM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CADM3
    Predesigned siRNA for gene silencing in human, mouse, rat CADM3
    Clone
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    OriGene clones in human, mouse for CADM3 (see all 12)
    OriGene ORF clones in mouse, rat for CADM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM3 (NM_021189)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CADM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM3
      QuantiTect SYBR Green Assays in human, mouse, rat CADM3
      QuantiFast Probe-based Assays in human, mouse, rat CADM3

    Additional mRNA sequence: 

    AF062733.2 AF363367.1 AF529206.1 AK001560.1 AK289541.1 AK308915.1 AY046418.1 AY358332.1 
    BC033819.1 

    6 DOTS entries:

    DT.421927  DT.100690853  DT.91758992  DT.100024622  DT.121397019  DT.102831425 

    Selected AceView cDNA sequences (see all 264):

    AI318397 BM722566 BM671230 R12129 AF363367 CR601573 BE502006 CA425659 
    BX281058 BM713575 CD676370 T30476 BQ640233 AU150243 BM704393 BM998664 
    BM697018 N47613 CB154618 BM972973 AW296169 BU729842 AW294540 BM708111 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:              -     -     -     -                                   -                       -                     
    SP2:              -     -     -     -     -     -                       -                       -                     
    SP3:                                                                                                                  
    SP4:              -     -     -     -     -     -                                                                     
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for CADM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CADM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTGCTCA
    CADM3 Expression
    About this image


    CADM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    CADM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CADM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.365689

    UniProtKB/Swiss-Prot: CADM3_HUMAN, Q8N126
    Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult
    brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum

        Custom PCR Arrays for CADM3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CADM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM3
    QuantiTect SYBR Green Assays in human, mouse, rat CADM3
    QuantiFast Probe-based Assays in human, mouse, rat CADM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CADM3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm31 , 5 cell adhesion molecule 31, 5 89.48(n)1
    95.2(a)1
      1 (80.33 cM)5
    943321  NM_053199.31  NP_444429.11 
     1733342545 
    chicken
    (Gallus gallus)
    Aves CADM36
    cell adhesion molecule 3
    51(a)
    1 ↔ 1
    25(1655296-1671257)
    lizard
    (Anolis carolinensis)
    Reptilia CADM36
    cell adhesion molecule 3
    60(a)
    1 ↔ 1
    GL345054.1(1323-10654)
    African clawed frog
    (Xenopus laevis)
    Amphibia necl1-pending-prov2 nectin-lke 1 75.23(n)    BC044084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadm31 cell adhesion molecule 3 59.58(n)
    56.95(a)
      692273  NM_001045246.1  NP_001038711.1 


    ENSEMBL Gene Tree for CADM3 (if available)
    TreeFam Gene Tree for CADM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CADM3 gene
    CADM42  CADM12  CRTAM2  CADM22  
    4 SIMAP similar genes for CADM3 using alignment to 1 protein entry:     CADM3_HUMAN:
    GYPC    CADM2    CADM4    CADM1

    Find genes that share paralogs with CADM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CADM3 (see all 459)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160383601,2
    F--159139742(+) TACTGG/CTAACC 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1404039911,2
    --159139771(+) TGCCCA/GTGAGT 2 -- us2k10--------
    rs1846105091,2
    --159139866(+) ATTAGC/TCCAGT 2 -- us2k10--------
    rs1894455931,2
    --159140001(+) CACATC/TCCAGC 2 -- us2k10--------
    rs780402231,2
    F--159140017(+) CTTGTG/ATCTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1497050091,2
    --159140069(+) TTTGAA/GCCTCA 2 -- us2k10--------
    rs1454555761,2
    --159140085(+) ACCTAG/TATAAT 2 -- us2k10--------
    rs1163837441,2
    C,F--159140240(+) GACTCG/AGAGAT 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs9653581,2
    C,F,O,A,H--159140349(+) CAGGAA/TTGACA 2 -- us2k1 tfbs3121Minor allele frequency- T:0.28NS MN EA NA PA EU CA WA CSA 9146
    rs9653591,2
    C,F,O,H--159140376(+) ACGCAG/AGGGTC 2 -- us2k122Minor allele frequency- A:0.07NA EA MN NS WA 4036

    HapMap Linkage Disequilibrium report for CADM3 (159141377 - 159173103 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CADM3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CADM3
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609743    OMIM disorders: --


    Find genes that share disorders with CADM3           About GenesLikeMe

    2 Novoseek inferred disease relationships for CADM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.28 4 19565570 (2), 14659875 (1), 11536053 (1)
    cancer 0 2 14659875 (1), 11536053 (1)

    Genetic Association Database (GAD): CADM3
    Human Genome Epidemiology (HuGE) Navigator: CADM3 (1 document)

    Export disorders for CADM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CADM3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CADM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PubMed id 11536053)1, 2, 3, 9 Fukuhara H.... Murakami Y. (Oncogene 2001)
    2. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PubMed id 15893517)1, 2, 9 Zhou Y.... Yuan J. (Biochim. Biophys. Acta 2005)
    3. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PubMed id 16467305)1, 2, 9 Dong X.... Rao Z. (J. Biol. Chem. 2006)
    4. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. (PubMed id 22291609)1, 4 Naitza S....Cucca F. (PLoS Genet. 2012)
    5. Nectin-like molecule 1 is a glycoprotein with a single N- glycosylation site at N290KS which influences its adhesion activity. (PubMed id 18420026)1, 2 Gao J.... Peng X. (Biochim. Biophys. Acta 2008)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57863 HGNC: 17601 AceView: FYandIGSF4B Ensembl:ENSG00000162706 euGenes: HUgn57863
    ECgene: CADM3 Kegg: 57863 H-InvDB: CADM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CADM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CADM3 gene:
    Search GeneIP for patents involving CADM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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