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Aliases for CADM3 Gene

Aliases for CADM3 Gene

  • Cell Adhesion Molecule 3 2 3
  • SynCAM3 3 4 6
  • IGSF4B 3 4 6
  • NECL1 3 4 6
  • TSLL1 3 4 6
  • Immunoglobulin Superfamily, Member 4B 2 3
  • Immunoglobulin Superfamily Member 4B 3 4
  • Synaptic Cell Adhesion Molecule 3 3 4
  • Brain Immunoglobulin Receptor 3 4
  • Nectin-Like Protein 1 3 4
  • TSLC1-Like Protein 1 3 4
  • Nectin-Like 1 2 3
  • Necl-1 3 4
  • Dendritic Cell Nectin-Like Protein 1 Short Isoform 3
  • TSLC1-Like 1 3
  • BIgR 3

External Ids for CADM3 Gene

Previous Symbols for CADM3 Gene

  • IGSF4B

Summaries for CADM3 Gene

Entrez Gene Summary for CADM3 Gene

  • IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CADM3 Gene

CADM3 (Cell Adhesion Molecule 3) is a Protein Coding gene. Among its related pathways are Cell junction organization and Cell junction organization. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CRTAM.

UniProtKB/Swiss-Prot for CADM3 Gene

  • Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Gene Wiki entry for CADM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM3 Gene

Genomics for CADM3 Gene

Genomic Location for CADM3 Gene

159,171,587 bp from pter
159,203,313 bp from pter
31,727 bases
Plus strand

Genomic View for CADM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CADM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM3 Gene

Regulatory Elements for CADM3 Gene

Proteins for CADM3 Gene

  • Protein details for CADM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell adhesion molecule 3
    Protein Accession:
    Secondary Accessions:
    • Q8IZQ9
    • Q9NVJ5
    • Q9UJP1

    Protein attributes for CADM3 Gene

    398 amino acids
    Molecular mass:
    43300 Da
    Quaternary structure:
    • Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).
    • Sequence=BAA91756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADM3 Gene

    Alternative splice isoforms for CADM3 Gene


neXtProt entry for CADM3 Gene

Proteomics data for CADM3 Gene at MOPED

Post-translational modifications for CADM3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn290

Other Protein References for CADM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CADM3 Gene

Domains for CADM3 Gene

Gene Families for CADM3 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Suggested Antigen Peptide Sequences for CADM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.:
    • Q8N126
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q8N126
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q8N126
  • Belongs to the nectin family.:
    • Q8N126
genes like me logo Genes that share domains with CADM3: view

Function for CADM3 Gene

Molecular function for CADM3 Gene

UniProtKB/Swiss-Prot Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
UniProtKB/Swiss-Prot Induction: Markedly in glioma cell lines and prostate cancer cell lines.

Gene Ontology (GO) - Molecular Function for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity ISS 12826663
genes like me logo Genes that share ontologies with CADM3: view

Phenotypes for CADM3 Gene

MGI mutant phenotypes for CADM3:
inferred from 2 alleles
GenomeRNAi human phenotypes for CADM3:
genes like me logo Genes that share phenotypes with CADM3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CADM3 Gene

Localization for CADM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM3 Gene

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at the cell-cell attached sites of the plasma membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CADM3 Gene COMPARTMENTS Subcellular localization image for CADM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction ISS 12826663
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CADM3: view

Pathways for CADM3 Gene

genes like me logo Genes that share pathways with CADM3: view

Gene Ontology (GO) - Biological Process for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12826663
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12826663
GO:0008104 protein localization IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CADM3: view

Compounds for CADM3 Gene

(1) HMDB Compounds for CADM3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CADM3: view

Transcripts for CADM3 Gene

Unigene Clusters for CADM3 Gene

Cell adhesion molecule 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - - -
SP4: - - - - - -
SP5: -

Relevant External Links for CADM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CADM3 Gene

mRNA expression in normal human tissues for CADM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.4) and Brain - Cerebellum (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CADM3 Gene

SOURCE GeneReport for Unigene cluster for CADM3 Gene Hs.365689

mRNA Expression by UniProt/SwissProt for CADM3 Gene

Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
genes like me logo Genes that share expressions with CADM3: view

Orthologs for CADM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CADM3 35
  • 99.22 (n)
  • 100 (a)
CADM3 36
  • 100 (a)
(Bos Taurus)
Mammalia CADM3 35
  • 90.99 (n)
  • 95.96 (a)
CADM3 36
  • 96 (a)
(Canis familiaris)
Mammalia CADM3 35
  • 89.66 (n)
  • 95.47 (a)
CADM3 36
  • 96 (a)
(Mus musculus)
Mammalia Cadm3 35
  • 89.48 (n)
  • 95.2 (a)
Cadm3 16
Cadm3 36
  • 95 (a)
(Monodelphis domestica)
Mammalia CADM3 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Cadm3 35
  • 88.97 (n)
  • 94.44 (a)
(Gallus gallus)
Aves CADM3 36
  • 51 (a)
(Anolis carolinensis)
Reptilia CADM3 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia necl1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490204 35
  • 64.04 (n)
  • 63.86 (a)
(Danio rerio)
Actinopterygii cadm3 35
  • 59.58 (n)
  • 56.95 (a)
cadm3 36
  • 51 (a)
Species with no ortholog for CADM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM3 Gene

Gene Tree for CADM3 (if available)
Gene Tree for CADM3 (if available)

Paralogs for CADM3 Gene

Paralogs for CADM3 Gene

Selected SIMAP similar genes for CADM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CADM3: view

Variants for CADM3 Gene

Sequence variations from dbSNP and Humsavar for CADM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs724363 -- 159,179,994(+) ATTTT(C/G)ATTTA intron-variant
rs862988 -- 159,191,090(+) TGACC(A/G)GAAGG intron-variant
rs862989 -- 159,191,489(+) TTAGG(A/G)TTATT intron-variant
rs862990 -- 159,193,329(+) GAACC(C/T)AGGTA intron-variant
rs862991 -- 159,194,574(+) TGAGC(A/G)TGGGG intron-variant

Relevant External Links for CADM3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CADM3 Gene

Disorders for CADM3 Gene

(2) Novoseek inferred disease relationships for CADM3 Gene

Disease -log(P) Hits PubMed IDs
tumors 1.28 4
cancer 0 2

Relevant External Links for CADM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CADM3: view

No data available for UniProtKB/Swiss-Prot for CADM3 Gene

Publications for CADM3 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H. … Murakami Y. (Oncogene 2001) 2 3 4 23
  2. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PMID: 15893517) Zhou Y. … Yuan J. (Biochim. Biophys. Acta 2005) 3 4 23
  3. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PMID: 16467305) Dong X. … Rao Z. (J. Biol. Chem. 2006) 3 4 23
  4. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). (PMID: 14659875) Fukami T. … Murakami Y. (Gene 2003) 3 23
  5. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PMID: 19565570) Raveh S. … Ben-Ze'ev A. (J. Cell. Biochem. 2009) 3 23

Products for CADM3 Gene

Sources for CADM3 Gene

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