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Aliases for CADM3 Gene

Aliases for CADM3 Gene

  • Cell Adhesion Molecule 3 2 3 5
  • Immunoglobulin Superfamily Member 4B 3 4
  • Synaptic Cell Adhesion Molecule 3 3 4
  • Brain Immunoglobulin Receptor 3 4
  • SynCAM3 3 4
  • Necl-1 3 4
  • IGSF4B 3 4
  • NECL1 3 4
  • TSLL1 3 4
  • Dendritic Cell Nectin-Like Protein 1 Short Isoform 3
  • Immunoglobulin Superfamily, Member 4B 2
  • Nectin-Like Protein 1 4
  • TSLC1-Like Protein 1 4
  • Nectin-Like 1 2
  • TSLC1-Like 1 3
  • BIgR 3

External Ids for CADM3 Gene

Previous HGNC Symbols for CADM3 Gene

  • IGSF4B

Previous GeneCards Identifiers for CADM3 Gene

  • GC01P157410
  • GC01P157411
  • GC01P130498

Summaries for CADM3 Gene

Entrez Gene Summary for CADM3 Gene

  • The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

GeneCards Summary for CADM3 Gene

CADM3 (Cell Adhesion Molecule 3) is a Protein Coding gene. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CADM2.

UniProtKB/Swiss-Prot for CADM3 Gene

  • Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Gene Wiki entry for CADM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM3 Gene

Genomics for CADM3 Gene

Regulatory Elements for CADM3 Gene

Enhancers for CADM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F159141 1 FANTOM5 Ensembl 12.1 -29.5 -29499 1.0 TBP SREBF2 SIN3A REST POLR2H JUND SMARCA4 POLR3A POLR2A ZBTB48 OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5 AIM2 OR10J1
GH01F159211 0.7 Ensembl 11.3 +39.9 39944 0.7 SCRT1 CTCF ZNF654 CEBPB TRIM22 REST RAD21 ATF3 SCRT2 IKZF1 CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1
GH01F159172 1.1 FANTOM5 Ensembl ENCODE 6.7 +1.4 1415 1.2 POLR2A SMARCA4 TEAD4 CTBP2 EBF1 ZBTB17 EZH2 ACKR1 CADM3-AS1 AIM2 ENSG00000212161 OR10J3 CADM3 OR6N1 OR6K3 FCER1A OR6N2
GH01F159219 0.5 Ensembl 10.8 +47.5 47514 0.2 ATF1 SMARCA4 POLR2A RFXANK CADM3 AIM2 OR10J2P FCER1A OR10J3 ENSG00000212161 CADM3-AS1 MPTX1
GH01F159173 0.7 ENCODE 0.8 +0.3 279 0.2 TBP SREBF2 SIN3A ZIC2 POLR2H JUND SMARCA4 ZBTB48 FOS ZBTB17 CADM3 RNA5SP60
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CADM3 on UCSC Golden Path with GeneCards custom track

Promoters for CADM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750709 113 601 TBP SREBF2 SIN3A REST ZIC2 POLR2H JUND ZBTB48 SMARCA4 POLR2A

Genomic Location for CADM3 Gene

Chromosome:
1
Start:
159,171,587 bp from pter
End:
159,203,313 bp from pter
Size:
31,727 bases
Orientation:
Plus strand

Genomic View for CADM3 Gene

Genes around CADM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM3 Gene

Proteins for CADM3 Gene

  • Protein details for CADM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N126-CADM3_HUMAN
    Recommended name:
    Cell adhesion molecule 3
    Protein Accession:
    Q8N126
    Secondary Accessions:
    • Q8IZQ9
    • Q9NVJ5
    • Q9UJP1

    Protein attributes for CADM3 Gene

    Size:
    398 amino acids
    Molecular mass:
    43300 Da
    Quaternary structure:
    • Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).
    SequenceCaution:
    • Sequence=BAA91756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADM3 Gene

    Alternative splice isoforms for CADM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM3 Gene

Post-translational modifications for CADM3 Gene

  • Glycosylation at Asn 290
  • Modification sites at PhosphoSitePlus

Other Protein References for CADM3 Gene

Antibody Products

  • R&D Systems Antibodies for CADM3 (IGSF4B/SynCAM3)

No data available for DME Specific Peptides for CADM3 Gene

Domains & Families for CADM3 Gene

Suggested Antigen Peptide Sequences for CADM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N126

UniProtKB/Swiss-Prot:

CADM3_HUMAN :
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
  • Belongs to the nectin family.
Domain:
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM3: view

Function for CADM3 Gene

Molecular function for CADM3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
UniProtKB/Swiss-Prot Induction:
Markedly in glioma cell lines and prostate cancer cell lines.

Gene Ontology (GO) - Molecular Function for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0042803 protein homodimerization activity ISS 12826663
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with CADM3: view
genes like me logo Genes that share phenotypes with CADM3: view

Animal Models for CADM3 Gene

MGI Knock Outs for CADM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM3

miRNA for CADM3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADM3 Gene

Localization for CADM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM3 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction ISS 12826663
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CADM3: view

Pathways & Interactions for CADM3 Gene

genes like me logo Genes that share pathways with CADM3: view

Gene Ontology (GO) - Biological Process for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12826663
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12826663
GO:0008037 cell recognition IBA --
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with CADM3: view

No data available for SIGNOR curated interactions for CADM3 Gene

Drugs & Compounds for CADM3 Gene

(1) Drugs for CADM3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CADM3: view

Transcripts for CADM3 Gene

Unigene Clusters for CADM3 Gene

Cell adhesion molecule 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CADM3 Gene

GeneLoc Exon Structure for
CADM3
ECgene alternative splicing isoforms for
CADM3

Expression for CADM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CADM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.4) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for CADM3 Gene

This gene is overexpressed in Frontal cortex (26.9), Cerebrospinal fluid (13.7), Spinal cord (8.9), and Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CADM3 Gene



NURSA nuclear receptor signaling pathways regulating expression of CADM3 Gene:

CADM3

SOURCE GeneReport for Unigene cluster for CADM3 Gene:

Hs.365689

mRNA Expression by UniProt/SwissProt for CADM3 Gene:

Q8N126-CADM3_HUMAN
Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
genes like me logo Genes that share expression patterns with CADM3: view

Primer Products

No data available for Protein tissue co-expression partners for CADM3 Gene

Orthologs for CADM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM3 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia CADM3 34 35
  • 90.99 (n)
dog
(Canis familiaris)
Mammalia CADM3 34 35
  • 89.66 (n)
mouse
(Mus musculus)
Mammalia Cadm3 34 16 35
  • 89.48 (n)
rat
(Rattus norvegicus)
Mammalia Cadm3 34
  • 88.97 (n)
oppossum
(Monodelphis domestica)
Mammalia CADM3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CADM3 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CADM3 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490204 34
  • 64.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia necl1-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii cadm3 34 35
  • 59.58 (n)
Species where no ortholog for CADM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM3 Gene

ENSEMBL:
Gene Tree for CADM3 (if available)
TreeFam:
Gene Tree for CADM3 (if available)

Paralogs for CADM3 Gene

Paralogs for CADM3 Gene

(4) SIMAP similar genes for CADM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CADM3: view

Variants for CADM3 Gene

Sequence variations from dbSNP and Humsavar for CADM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920866 Uncertain significance 159,192,730(+) TGCTA(A/C/G)GTGAG reference, missense
rs10681414 -- 159,180,591(+) TTTTT(-/TT)AAGTG intron-variant
rs111437756 -- 159,176,665(+) TCCAA(C/T)TCTGT intron-variant
rs111557538 -- 159,185,936(+) AGTAC(A/G)AAGTA intron-variant
rs111723656 -- 159,185,565(+) TGTGT(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADM3 Gene

Variant ID Type Subtype PubMed ID
nsv952221 CNV deletion 24416366

Variation tolerance for CADM3 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CADM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM3 Gene

Disorders for CADM3 Gene

Relevant External Links for CADM3

Genetic Association Database (GAD)
CADM3
Human Genome Epidemiology (HuGE) Navigator
CADM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADM3

No disorders were found for CADM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CADM3 Gene

Publications for CADM3 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H. … Murakami Y. (Oncogene 2001) 2 3 4 22 64
  2. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PMID: 16467305) Dong X. … Rao Z. (J. Biol. Chem. 2006) 3 4 22 64
  3. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PMID: 15893517) Zhou Y. … Yuan J. (Biochim. Biophys. Acta 2005) 3 4 22 64
  4. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. (PMID: 22291609) Naitza S. … Cucca F. (PLoS Genet. 2012) 3 46 64
  5. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PMID: 19565570) Raveh S. … Ben-Ze'ev A. (J. Cell. Biochem. 2009) 3 22 64

Products for CADM3 Gene

Sources for CADM3 Gene

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