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Aliases for CADM3 Gene

Aliases for CADM3 Gene

  • Cell Adhesion Molecule 3 2 3 5
  • Immunoglobulin Superfamily, Member 4B 2 3
  • Immunoglobulin Superfamily Member 4B 3 4
  • Synaptic Cell Adhesion Molecule 3 3 4
  • Brain Immunoglobulin Receptor 3 4
  • Nectin-Like Protein 1 3 4
  • TSLC1-Like Protein 1 3 4
  • Nectin-Like 1 2 3
  • SynCAM3 3 4
  • Necl-1 3 4
  • IGSF4B 3 4
  • NECL1 3 4
  • TSLL1 3 4
  • Dendritic Cell Nectin-Like Protein 1 Short Isoform 3
  • TSLC1-Like 1 3
  • BIgR 3

External Ids for CADM3 Gene

Previous HGNC Symbols for CADM3 Gene

  • IGSF4B

Previous GeneCards Identifiers for CADM3 Gene

  • GC01P157410
  • GC01P157411
  • GC01P130498

Summaries for CADM3 Gene

Entrez Gene Summary for CADM3 Gene

  • IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CADM3 Gene

CADM3 (Cell Adhesion Molecule 3) is a Protein Coding gene. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CRTAM.

UniProtKB/Swiss-Prot for CADM3 Gene

  • Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Gene Wiki entry for CADM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM3 Gene

Genomics for CADM3 Gene

Regulatory Elements for CADM3 Gene

Genomic Location for CADM3 Gene

Chromosome:
1
Start:
159,171,587 bp from pter
End:
159,203,313 bp from pter
Size:
31,727 bases
Orientation:
Plus strand

Genomic View for CADM3 Gene

Genes around CADM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM3 Gene

Proteins for CADM3 Gene

  • Protein details for CADM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N126-CADM3_HUMAN
    Recommended name:
    Cell adhesion molecule 3
    Protein Accession:
    Q8N126
    Secondary Accessions:
    • Q8IZQ9
    • Q9NVJ5
    • Q9UJP1

    Protein attributes for CADM3 Gene

    Size:
    398 amino acids
    Molecular mass:
    43300 Da
    Quaternary structure:
    • Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).
    SequenceCaution:
    • Sequence=BAA91756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADM3 Gene

    Alternative splice isoforms for CADM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM3 Gene

Proteomics data for CADM3 Gene at MOPED

Post-translational modifications for CADM3 Gene

  • Glycosylation at Asn 290
  • Modification sites at PhosphoSitePlus

Other Protein References for CADM3 Gene

Antibody Products

  • R&D Systems Antibodies for CADM3 (IGSF4B/SynCAM3)

No data available for DME Specific Peptides for CADM3 Gene

Domains & Families for CADM3 Gene

Suggested Antigen Peptide Sequences for CADM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N126

UniProtKB/Swiss-Prot:

CADM3_HUMAN :
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
  • Belongs to the nectin family.
Domain:
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM3: view

Function for CADM3 Gene

Molecular function for CADM3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
UniProtKB/Swiss-Prot Induction:
Markedly in glioma cell lines and prostate cancer cell lines.

Gene Ontology (GO) - Molecular Function for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with CADM3: view
genes like me logo Genes that share phenotypes with CADM3: view

Animal Models for CADM3 Gene

MGI Knock Outs for CADM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM3

miRNA for CADM3 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADM3 Gene

Localization for CADM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM3 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADM3 Gene COMPARTMENTS Subcellular localization image for CADM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with CADM3: view

Pathways & Interactions for CADM3 Gene

genes like me logo Genes that share pathways with CADM3: view

Gene Ontology (GO) - Biological Process for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12826663
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CADM3: view

No data available for SIGNOR curated interactions for CADM3 Gene

Drugs & Compounds for CADM3 Gene

(1) Drugs for CADM3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CADM3: view

Transcripts for CADM3 Gene

Unigene Clusters for CADM3 Gene

Cell adhesion molecule 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CADM3 Gene

GeneLoc Exon Structure for
CADM3
ECgene alternative splicing isoforms for
CADM3

Expression for CADM3 Gene

mRNA expression in normal human tissues for CADM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.4) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for CADM3 Gene

This gene is overexpressed in Frontal cortex (26.9), Cerebrospinal fluid (13.7), Spinal cord (8.9), and Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CADM3 Gene



SOURCE GeneReport for Unigene cluster for CADM3 Gene Hs.365689

mRNA Expression by UniProt/SwissProt for CADM3 Gene

Q8N126-CADM3_HUMAN
Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
genes like me logo Genes that share expression patterns with CADM3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CADM3 Gene

Orthologs for CADM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM3 36
  • 100 (a)
OneToOne
CADM3 35
  • 99.22 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CADM3 35
  • 90.99 (n)
  • 95.96 (a)
CADM3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CADM3 36
  • 96 (a)
OneToOne
CADM3 35
  • 89.66 (n)
  • 95.47 (a)
mouse
(Mus musculus)
Mammalia Cadm3 36
  • 95 (a)
OneToOne
Cadm3 16
Cadm3 35
  • 89.48 (n)
  • 95.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CADM3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadm3 35
  • 88.97 (n)
  • 94.44 (a)
chicken
(Gallus gallus)
Aves CADM3 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CADM3 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia necl1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490204 35
  • 64.04 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii cadm3 35
  • 59.58 (n)
  • 56.95 (a)
cadm3 36
  • 51 (a)
OneToOne
Species with no ortholog for CADM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM3 Gene

ENSEMBL:
Gene Tree for CADM3 (if available)
TreeFam:
Gene Tree for CADM3 (if available)

Paralogs for CADM3 Gene

Paralogs for CADM3 Gene

(4) SIMAP similar genes for CADM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CADM3: view

Variants for CADM3 Gene

Sequence variations from dbSNP and Humsavar for CADM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3026987 - 159,193,524(+) CAGCC(C/T)GGCTC reference, missense
rs724363 -- 159,179,994(+) ATTTT(C/G)ATTTA intron-variant
rs965358 -- 159,170,559(+) CAGGA(A/T)TGACA upstream-variant-2KB
rs965359 -- 159,170,586(+) ACGCA(A/G)GGGTC upstream-variant-2KB
rs862988 -- 159,191,090(+) TGACC(A/G)GAAGG intron-variant

Variation tolerance for CADM3 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADM3 Gene

HapMap Linkage Disequilibrium report
CADM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CADM3 Gene

Disorders for CADM3 Gene

Relevant External Links for CADM3

Genetic Association Database (GAD)
CADM3
Human Genome Epidemiology (HuGE) Navigator
CADM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADM3

No disorders were found for CADM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CADM3 Gene

Publications for CADM3 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H. … Murakami Y. (Oncogene 2001) 2 3 4 23 67
  2. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PMID: 19565570) Raveh S. … Ben-Ze'ev A. (J. Cell. Biochem. 2009) 3 23
  3. Crystal structure of the V domain of human Nectin-like molecule- 1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PMID: 16467305) Dong X. … Rao Z. (J. Biol. Chem. 2006) 3 23
  4. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PMID: 15893517) Zhou Y. … Yuan J. (Biochim. Biophys. Acta 2005) 3 23
  5. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). (PMID: 14659875) Fukami T. … Murakami Y. (Gene 2003) 3 23

Products for CADM3 Gene

Sources for CADM3 Gene

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