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Aliases for CADM2 Gene

Aliases for CADM2 Gene

  • Cell Adhesion Molecule 2 2 3 5
  • Immunoglobulin Superfamily, Member 4D 2 3
  • Immunoglobulin Superfamily Member 4D 3 4
  • Synaptic Cell Adhesion Molecule 2 3 4
  • Nectin-Like Protein 3 3 4
  • Nectin-Like 3 2 3
  • SynCAM 2 3 4
  • Necl-3 3 4
  • IGSF4D 3 4
  • NECL3 3 4
  • SynCAM2 3

External Ids for CADM2 Gene

Previous HGNC Symbols for CADM2 Gene

  • IGSF4D

Previous GeneCards Identifiers for CADM2 Gene

  • GC03P085092
  • GC03P085858

Summaries for CADM2 Gene

Entrez Gene Summary for CADM2 Gene

  • This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CADM2 Gene

CADM2 (Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell junction organization. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot for CADM2 Gene

  • Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM2 Gene

Genomics for CADM2 Gene

Regulatory Elements for CADM2 Gene

Promoters for CADM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CADM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CADM2 Gene

Chromosome:
3
Start:
84,958,981 bp from pter
End:
86,074,429 bp from pter
Size:
1,115,449 bases
Orientation:
Plus strand

Genomic View for CADM2 Gene

Genes around CADM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM2 Gene

Proteins for CADM2 Gene

  • Protein details for CADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3J6-CADM2_HUMAN
    Recommended name:
    Cell adhesion molecule 2
    Protein Accession:
    Q8N3J6
    Secondary Accessions:
    • G3XHN7
    • G3XHN8
    • Q3KQY9
    • Q658Q7
    • Q8IZP8

    Protein attributes for CADM2 Gene

    Size:
    435 amino acids
    Molecular mass:
    47554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CADM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM2 Gene

Proteomics data for CADM2 Gene at MOPED

Post-translational modifications for CADM2 Gene

  • Glycosylation at Asn 31, Asn 51, and Asn 291
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CADM2 Gene

Domains & Families for CADM2 Gene

Suggested Antigen Peptide Sequences for CADM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3J6

UniProtKB/Swiss-Prot:

CADM2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM2: view

Function for CADM2 Gene

Molecular function for CADM2 Gene

UniProtKB/Swiss-Prot Function:
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

Gene Ontology (GO) - Molecular Function for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with CADM2: view
genes like me logo Genes that share phenotypes with CADM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM2

miRNA for CADM2 Gene

miRTarBase miRNAs that target CADM2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CADM2 Gene

Localization for CADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADM2 Gene COMPARTMENTS Subcellular localization image for CADM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with CADM2: view

Pathways & Interactions for CADM2 Gene

genes like me logo Genes that share pathways with CADM2: view

Pathways by source for CADM2 Gene

Interacting Proteins for CADM2 Gene

Gene Ontology (GO) - Biological Process for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
genes like me logo Genes that share ontologies with CADM2: view

No data available for SIGNOR curated interactions for CADM2 Gene

Drugs & Compounds for CADM2 Gene

No Compound Related Data Available

Transcripts for CADM2 Gene

Unigene Clusters for CADM2 Gene

Cell adhesion molecule 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CADM2 Gene

No ASD Table

Relevant External Links for CADM2 Gene

GeneLoc Exon Structure for
CADM2
ECgene alternative splicing isoforms for
CADM2

Expression for CADM2 Gene

mRNA expression in normal human tissues for CADM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for CADM2 Gene

This gene is overexpressed in Retina (29.3) and Frontal cortex (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CADM2 Gene



SOURCE GeneReport for Unigene cluster for CADM2 Gene Hs.164578

genes like me logo Genes that share expression patterns with CADM2: view

Protein tissue co-expression partners for CADM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CADM2 Gene

Orthologs for CADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM2 35
  • 99.62 (n)
  • 100 (a)
CADM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CADM2 36
  • 99 (a)
OneToOne
CADM2 35
  • 94.79 (n)
  • 99.54 (a)
dog
(Canis familiaris)
Mammalia CADM2 35
  • 95.4 (n)
  • 99.08 (a)
CADM2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadm2 35
  • 91.56 (n)
  • 98.99 (a)
Cadm2 16
Cadm2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CADM2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CADM2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadm2 35
  • 91.39 (n)
  • 98.99 (a)
chicken
(Gallus gallus)
Aves CADM2 35
  • 84.92 (n)
  • 87.74 (a)
CADM2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cadm2 35
  • 77.29 (n)
  • 80.14 (a)
zebrafish
(Danio rerio)
Actinopterygii cadm2a 36
  • 70 (a)
OneToMany
cadm2b 36
  • 72 (a)
OneToMany
cadm2b 35
  • 68.03 (n)
  • 69.64 (a)
zgc66339 35
Species with no ortholog for CADM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM2 Gene

ENSEMBL:
Gene Tree for CADM2 (if available)
TreeFam:
Gene Tree for CADM2 (if available)

Paralogs for CADM2 Gene

Paralogs for CADM2 Gene

(7) SIMAP similar genes for CADM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CADM2: view

Variants for CADM2 Gene

Sequence variations from dbSNP and Humsavar for CADM2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3307 -- 84,984,488(-) AAACA(A/C)GGTTA intron-variant
rs533529 -- 84,963,829(+) CATGT(A/G)TTAAC intron-variant
rs721106 -- 85,095,622(-) AATAT(A/C)CTTTT intron-variant
rs424029 -- 84,960,888(+) GGGCA(A/G)GGGCT intron-variant
rs724304 -- 85,558,989(-) TCAAA(G/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADM2 Gene

Variant ID Type Subtype PubMed ID
nsv877091 CNV Loss 21882294
nsv471620 CNV Loss 15918152
nsv877093 CNV Gain 21882294
nsv877094 CNV Loss 21882294
dgv5186n71 CNV Loss 21882294
dgv5187n71 CNV Loss 21882294
nsv460748 CNV Loss 19166990
nsv470716 CNV Loss 18288195
esv2662517 CNV Deletion 23128226
nsv877100 CNV Loss 21882294
esv2646105 CNV Deletion 19546169
esv1739393 CNV Insertion 17803354
nsv522622 CNV Loss 19592680
nsv526621 CNV Loss 19592680
nsv522784 CNV Loss 19592680
esv2657670 CNV Deletion 23128226
nsv527642 CNV Loss 19592680
esv268861 CNV Insertion 20981092
esv272335 CNV Insertion 20981092
esv2725621 CNV Deletion 23290073
nsv877101 CNV Gain 21882294
nsv822172 CNV Loss 20364138
dgv5188n71 CNV Loss 21882294
nsv877104 CNV Loss 21882294
dgv610n27 CNV Loss 19166990
nsv877105 CNV Loss 21882294
esv273264 CNV Insertion 20981092
esv270242 CNV Insertion 20981092
nsv522825 CNV Loss 19592680
esv2725622 CNV Deletion 23290073
nsv460753 CNV Loss 19166990
dgv5189n71 CNV Loss 21882294
esv2725623 CNV Deletion 23290073
esv1692963 CNV Deletion 17803354
dgv5190n71 CNV Loss 21882294
esv22210 CNV Loss 19812545
esv2671756 CNV Deletion 23128226
nsv877109 CNV Loss 21882294
dgv611n27 CNV Loss 19166990
nsv470727 CNV Gain 18288195
nsv877112 CNV Loss 21882294

Variation tolerance for CADM2 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADM2 Gene

HapMap Linkage Disequilibrium report
CADM2
Human Gene Mutation Database (HGMD)
CADM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM2 Gene

Disorders for CADM2 Gene

Relevant External Links for CADM2

Genetic Association Database (GAD)
CADM2
Human Genome Epidemiology (HuGE) Navigator
CADM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADM2

No disorders were found for CADM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CADM2 Gene

Publications for CADM2 Gene

  1. A novel splicing variant of CADM2 as a protective transcript of psoriasis. (PMID: 21864505) Hiruma A. … Oka A. (Biochem. Biophys. Res. Commun. 2011) 3 4 67
  2. Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. (PMID: 16311015) Biederer T. (Genomics 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. (PMID: 25199915) Broer L. … Murabito J.M. (J. Gerontol. A Biol. Sci. Med. Sci. 2015) 3
  5. Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy. (PMID: 24240726) Yang S. … Zhou W.P. (J. Cancer Res. Clin. Oncol. 2014) 3

Products for CADM2 Gene

Sources for CADM2 Gene

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