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CADM2 Gene

protein-coding   GIFtS: 53
GCID: GC03P085008

Cell Adhesion Molecule 2

(Previous names: immunoglobulin superfamily, member 4D)
(Previous symbol: IGSF4D)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Adhesion Molecule 21 2     Synaptic Cell Adhesion Molecule 22 3
IGSF4D1 2 3 5     SynCAM 22 3
NECL32 3 5     Necl-32
Immunoglobulin Superfamily, Member 4D1 2     synCAM22
Nectin-Like 31 2     IgSF4D3
Immunoglobulin Superfamily Member 4D2 3     NECL-33
Nectin-Like Protein 32 3     SYNCAM25

External Ids:    HGNC: 298491   Entrez Gene: 2535592   Ensembl: ENSG000001751617   OMIM: 6099385   UniProtKB: Q8N3J63   

Export aliases for CADM2 gene to outside databases

Previous GC identifers: GC03P085092 GC03P085858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CADM2 Gene:
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the
immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1
binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact
with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for CADM2 Gene:
CADM2 (cell adhesion molecule 2) is a protein-coding gene. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CADM2_HUMAN, Q8N3J6
Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family
members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic
adhesion. Preferentially binds to oligodendrocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CADM2 gene promoter:
         Nkx3-1   Nkx3-1 v4   ATF-2   GCNF   Nkx3-1 v1   Nkx3-1 v2   GCNF-1   Nkx3-1 v3   Zic3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCADM2 promoter sequence
   Search Chromatin IP Primers for CADM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12.1   Ensembl cytogenetic band:  3p12.1   HGNC cytogenetic band: 3p12.2

CADM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P085008:  view genomic region     (about GC identifiers)

Start:
85,008,132 bp from pter      End:
86,123,579 bp from pter
Size:
1,115,448 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CADM2_HUMAN, Q8N3J6 (See protein sequence)
Recommended Name: Cell adhesion molecule 2 precursor  
Size: 435 amino acids; 47554 Da
Secondary accessions: Q3KQY9 Q658Q7 Q8IZP8
Alternative splicing: 3 isoforms:  Q8N3J6-1   Q8N3J6-2   Q8N3J6-3   

Explore the universe of human proteins at neXtProt for CADM2: NX_Q8N3J6

Explore proteomics data for CADM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn31, Asn51, Asn291
  • Modification sites at PhosphoSitePlus

  • See CADM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001161146.1  NP_001161147.1  NP_001243431.1  NP_001243432.1  NP_001243433.1  NP_001243434.1  NP_694854.2  

    ENSEMBL proteins: 
     ENSP00000373200   ENSP00000384575   ENSP00000384193  
    Reactome Protein details: Q8N3J6

    CADM2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM2

     
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    antibodies-online peptides for CADM2

    CADM2 Antibody Products:

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    antibodies-online antibodies for CADM2 (41 products) 

    CADM2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CADM2
    Cloud-Clone Corp. CLIAs for CADM2
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    antibodies-online kits for CADM2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q8N3J6

    ProtoNet protein and cluster: Q8N3J6

    Selected Blocks protein domains (see all 6):
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003597 Immunoglobulin C-type
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: CADM2_HUMAN, Q8N3J6
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CADM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM2_HUMAN, Q8N3J6
    Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family
    members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic
    adhesion. Preferentially binds to oligodendrocytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CADM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CADM2:
     Decreased influenza A virus in 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cadm2):
     nervous system 

    Find genes that share phenotypes with CADM2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CADM2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CADM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM2 (see all 123):
    hsa-miR-520e hsa-miR-106a hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-219-5p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCADM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CADM2
    Predesigned siRNA for gene silencing in human, mouse, rat CADM2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CADM2 (see all 15)
    OriGene ORF clones in mouse, rat for CADM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CADM2 (NM_153184)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CADM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADM2_HUMAN, Q8N3J6: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection,
    axon. Note=Found in the axoplasm of myelinated axons
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2
    endosome1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--

    Find genes that share ontologies with CADM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CADM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49


    Find genes that share SuperPaths with CADM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CADM2
        Adherens junctions interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CADM2
    Interactions:

        Search GeneGlobe Interaction Network for CADM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CADM2 (ENSP000003841934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHEENSP000003749834STRING: ENSP00000374983
    PILRAENSP000001985364STRING: ENSP00000198536
    CADM3ENSP000003571064STRING: ENSP00000357106
    CADM4ENSP000002223744STRING: ENSP00000222374
    --ENSP000003111534STRING: ENSP00000311153
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007420brain development IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0045216cell-cell junction organization TAS--

    Find genes that share ontologies with CADM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CADM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CADM2 gene (7 alternative transcripts): 
    NM_001167674.1  NM_001167675.1  NM_001256502.1  NM_001256503.1  NM_001256504.1  NM_001256505.1  NM_153184.3  

    Unigene Cluster for CADM2:

    Cell adhesion molecule 2
    Hs.164578  [show with all ESTs]
    Unigene Representative Sequence: NM_001167674
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383699(uc003dqj.3 uc003dqk.3 uc003dqm.2 uc021xay.1 uc021xaz.1 uc021xba.1 uc003dql.3)
    ENST00000473523 ENST00000485126 ENST00000407528 ENST00000405615
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate CADM2 (see all 123):
    hsa-miR-520e hsa-miR-106a hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-219-5p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCADM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CADM2
    Predesigned siRNA for gene silencing in human, mouse, rat CADM2
    Clone
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    OriGene ORF clones in mouse, rat for CADM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CADM2 (NM_153184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CADM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM2
      QuantiTect SYBR Green Assays in human, mouse, rat CADM2
      QuantiFast Probe-based Assays in human, mouse, rat CADM2

    Additional mRNA sequence: 

    AB646739.1 AB646740.1 AB646741.1 AB646742.1 AB646743.1 AF538973.1 AK090787.1 AK094943.1 
    AK095545.1 AK295885.1 AL833049.1 AL834270.1 BC040985.1 BC063484.1 BC105999.1 BC112136.1 
    BC112138.1 BX538255.1 

    9 DOTS entries:

    DT.444066  DT.40293011  DT.95348713  DT.97791854  DT.92010932  DT.101977799  DT.453189  DT.120899001 
    DT.91748486 

    13 AceView cDNA sequences:

    M85624 BM674450 BM717070 AF538973 AW902042 AL833049 AL711834 BX954585 
    N62301 N77591 AL834270 NM_153184 AA640422 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CADM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAACTCTT
    CADM2 Expression
    About this image


    CADM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Brain (Nervous System)
             Cerebral Cortex
    CADM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CADM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164578
        Custom PCR Arrays for CADM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CADM2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm21 , 5 cell adhesion molecule 21, 5 91.56(n)1
    98.99(a)1
      16 (37.96 cM)5
    2398571  NM_178721.41  NP_848836.21 
     666554215 
    chicken
    (Gallus gallus)
    Aves CADM21 cell adhesion molecule 2 84.92(n)
    87.74(a)
      418463  XM_004938340.1  XP_004938397.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    43(a)
    1 ↔ many
    1 ↔ many
    3(160196386-160589324)
    GL344307.1(746-7201)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cadm21 cell adhesion molecule 2 77.29(n)
    80.14(a)
      448238  NM_001005713.1  NP_001005713.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663392 hypothetical protein MGC66339 74.17(n)   393637  BC057517.1 


    ENSEMBL Gene Tree for CADM2 (if available)
    TreeFam Gene Tree for CADM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CADM2 gene
    CADM42  CADM32  CADM12  CRTAM2  
    7 SIMAP similar genes for CADM2 using alignment to 4 protein entries:     CADM2_HUMAN (see all proteins):
    DKFZp686F1789    CADM3    CNTNAP2    GYPC    CADM1    SMAGP
    CADM4

    Find genes that share paralogs with CADM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CADM2 (see all 21300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815544821,2
    --85006242(+) ATTTTA/CTTCAA 2 -- us2k10--------
    rs126294421,2
    C,F,H--85006247(+) CTTCAA/G/TTATAA 2 -- us2k14NA CSA EA 246
    rs762192461,2
    F--85006263(+) TTAAAG/ATTTTT 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1868469131,2
    --85006311(+) TCCAGA/CTCCTT 2 -- us2k10--------
    rs1915271971,2
    --85006366(+) TGCCCA/GAGGTC 2 -- us2k10--------
    rs784144351,2
    F--85006378(+) TACAGC/TTAGAA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1165779851,2
    C,F--85006413(+) AACTCC/TGACTA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1174419341,2
    F--85006500(+) AGTCAA/TTAATG 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs795267941,2
    C--85006615(+) TCTCCT/CACAAT 2 -- us2k14Minor allele frequency- C:0.04CSA WA NA EA 360
    rs731376371,2
    C,F--85006865(+) GGTTTC/TTATTG 2 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for CADM2 (85008132 - 85258132 bp, first 250kb of CADM2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CADM2 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725622CNV Deletion23290073
    esv2662517CNV Deletion23128226
    esv1692963CNV Deletion17803354
    esv2725623CNV Deletion23290073
    esv2657670CNV Deletion23128226
    esv2671756CNV Deletion23128226
    esv2725621CNV Deletion23290073
    esv2646105CNV Deletion19546169
    esv270242CNV Insertion20981092
    esv268861CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609938    OMIM disorders: --


    Find genes that share disorders with CADM2           About GenesLikeMe

    Genetic Association Database (GAD): CADM2
    Human Genome Epidemiology (HuGE) Navigator: CADM2 (2 documents)

    Export disorders for CADM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CADM2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CADM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
    4. Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. (PubMed id 16311015)1, 9 Biederer T. (Genomics 2006)
    5. Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy. (PubMed id 24240726)1 Yang S....Zhou W.P. (J. Cancer Res. Clin. Oncol. 2014)
    6. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    7. Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression. (PubMed id 23643812)1 He W....Chang G. (Biochem. Biophys. Res. Commun. 2013)
    8. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)4 Tao S....Sun J. (Carcinogenesis 2012)
    9. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)1 Service S.K....Freimer N.B. (Transl Psychiatry 2012)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253559 HGNC: 29849 AceView: IGSF4D Ensembl:ENSG00000175161 euGenes: HUgn253559
    ECgene: CADM2 H-InvDB: CADM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CADM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CADM2 gene:
    Search GeneIP for patents involving CADM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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