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Aliases for CADM2 Gene

Aliases for CADM2 Gene

  • Cell Adhesion Molecule 2 2 3
  • IGSF4D 3 4 6
  • NECL3 3 4 6
  • Immunoglobulin Superfamily, Member 4D 2 3
  • Immunoglobulin Superfamily Member 4D 3 4
  • Synaptic Cell Adhesion Molecule 2 3 4
  • Nectin-Like Protein 3 3 4
  • Nectin-Like 3 2 3
  • SynCAM 2 3 4
  • SynCAM2 3 6
  • Necl-3 3 4

External Ids for CADM2 Gene

Previous Symbols for CADM2 Gene

  • IGSF4D

Summaries for CADM2 Gene

Entrez Gene Summary for CADM2 Gene

  • This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CADM2 Gene

CADM2 (Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell junction organization and Cell junction organization. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot for CADM2 Gene

  • Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM2 Gene

Genomics for CADM2 Gene

Genomic Location for CADM2 Gene

Start:
84,958,981 bp from pter
End:
86,074,429 bp from pter
Size:
1,115,449 bases
Orientation:
Plus strand

Genomic View for CADM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM2 Gene

Regulatory Elements for CADM2 Gene

Proteins for CADM2 Gene

  • Protein details for CADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3J6-CADM2_HUMAN
    Recommended name:
    Cell adhesion molecule 2
    Protein Accession:
    Q8N3J6
    Secondary Accessions:
    • G3XHN7
    • G3XHN8
    • Q3KQY9
    • Q658Q7
    • Q8IZP8

    Protein attributes for CADM2 Gene

    Size:
    435 amino acids
    Molecular mass:
    47554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CADM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM2 Gene

Proteomics data for CADM2 Gene at MOPED

Post-translational modifications for CADM2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn31, Asn51, and Asn291

Other Protein References for CADM2 Gene

No data available for DME Specific Peptides for CADM2 Gene

Domains for CADM2 Gene

Gene Families for CADM2 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

UniProtKB/Swiss-Prot:

CADM2_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q8N3J6
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q8N3J6
Family:
  • Belongs to the nectin family.:
    • Q8N3J6
genes like me logo Genes that share domains with CADM2: view

Function for CADM2 Gene

Molecular function for CADM2 Gene

UniProtKB/Swiss-Prot Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

Gene Ontology (GO) - Molecular Function for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CADM2: view

Phenotypes for CADM2 Gene

MGI mutant phenotypes for CADM2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CADM2:
genes like me logo Genes that share phenotypes with CADM2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CADM2 Gene

Localization for CADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CADM2 Gene COMPARTMENTS Subcellular localization image for CADM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with CADM2: view

Pathways for CADM2 Gene

genes like me logo Genes that share pathways with CADM2: view

Pathways by source for CADM2 Gene

Interacting Proteins for CADM2 Gene

Gene Ontology (GO) - Biological Process for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007420 brain development IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CADM2: view

Transcripts for CADM2 Gene

Unigene Clusters for CADM2 Gene

Cell adhesion molecule 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CADM2 Gene

No ASD Table

Relevant External Links for CADM2 Gene

GeneLoc Exon Structure for
CADM2
ECgene alternative splicing isoforms for
CADM2

Expression for CADM2 Gene

mRNA expression in normal human tissues for CADM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.3), Brain - Anterior cingulate cortex (BA24) (5.5), and Brain - Cortex (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CADM2 Gene

SOURCE GeneReport for Unigene cluster for CADM2 Gene Hs.164578

genes like me logo Genes that share expressions with CADM2: view

Orthologs for CADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM2 36
  • 99.62 (n)
  • 100 (a)
CADM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CADM2 36
  • 94.79 (n)
  • 99.54 (a)
CADM2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CADM2 36
  • 95.4 (n)
  • 99.08 (a)
CADM2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cadm2 36
  • 91.56 (n)
  • 98.99 (a)
Cadm2 16
Cadm2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CADM2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CADM2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cadm2 36
  • 91.39 (n)
  • 98.99 (a)
chicken
(Gallus gallus)
Aves CADM2 36
  • 84.92 (n)
  • 87.74 (a)
CADM2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cadm2 36
  • 77.29 (n)
  • 80.14 (a)
zebrafish
(Danio rerio)
Actinopterygii cadm2a 37
  • 70 (a)
OneToMany
cadm2b 36
  • 68.03 (n)
  • 69.64 (a)
cadm2b 37
  • 72 (a)
OneToMany
zgc66339 36
Species with no ortholog for CADM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM2 Gene

ENSEMBL:
Gene Tree for CADM2 (if available)
TreeFam:
Gene Tree for CADM2 (if available)

Paralogs for CADM2 Gene

Paralogs for CADM2 Gene

Selected SIMAP similar genes for CADM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CADM2: view

Variants for CADM2 Gene

Sequence variations from dbSNP and Humsavar for CADM2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3158 -- 85,744,438(-) aatgt(A/G)taata intron-variant
rs3159 -- 85,744,338(-) ATGTA(A/C)AATTA intron-variant
rs3307 -- 84,984,488(-) AAACA(A/C)GGTTA intron-variant
rs424029 -- 84,960,888(+) GGGCA(A/G)GGGCT intron-variant
rs533529 -- 84,963,829(+) CATGT(A/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADM2 Gene

Variant ID Type Subtype PubMed ID
nsv877091 CNV Loss 21882294
nsv471620 CNV Loss 15918152
nsv877093 CNV Gain 21882294
nsv877094 CNV Loss 21882294
dgv5186n71 CNV Loss 21882294
dgv5187n71 CNV Loss 21882294
nsv460748 CNV Loss 19166990
nsv470716 CNV Loss 18288195
esv2662517 CNV Deletion 23128226
nsv877100 CNV Loss 21882294
esv2646105 CNV Deletion 19546169
esv1739393 CNV Insertion 17803354
nsv522622 CNV Loss 19592680
nsv526621 CNV Loss 19592680
nsv522784 CNV Loss 19592680
esv2657670 CNV Deletion 23128226
nsv527642 CNV Loss 19592680
esv268861 CNV Insertion 20981092
esv272335 CNV Insertion 20981092
esv2725621 CNV Deletion 23290073
nsv877101 CNV Gain 21882294
nsv822172 CNV Loss 20364138
dgv5188n71 CNV Loss 21882294
nsv877104 CNV Loss 21882294
dgv610n27 CNV Loss 19166990
nsv877105 CNV Loss 21882294
esv273264 CNV Insertion 20981092
esv270242 CNV Insertion 20981092
nsv522825 CNV Loss 19592680
esv2725622 CNV Deletion 23290073
nsv460753 CNV Loss 19166990
dgv5189n71 CNV Loss 21882294
esv2725623 CNV Deletion 23290073
esv1692963 CNV Deletion 17803354
dgv5190n71 CNV Loss 21882294
esv22210 CNV Loss 19812545
esv2671756 CNV Deletion 23128226
nsv877109 CNV Loss 21882294
dgv611n27 CNV Loss 19166990
nsv470727 CNV Gain 18288195
nsv877112 CNV Loss 21882294

Relevant External Links for CADM2 Gene

HapMap Linkage Disequilibrium report
CADM2
Human Gene Mutation Database (HGMD)
CADM2

Disorders for CADM2 Gene

Relevant External Links for CADM2

Genetic Association Database (GAD)
CADM2
Human Genome Epidemiology (HuGE) Navigator
CADM2
genes like me logo Genes that share disorders with CADM2: view

No data available for UniProtKB/Swiss-Prot for CADM2 Gene

Publications for CADM2 Gene

  1. Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. (PMID: 16311015) Biederer T. (Genomics 2006) 3 23
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 49
  5. A novel splicing variant of CADM2 as a protective transcript of psoriasis. (PMID: 21864505) Hiruma A. … Oka A. (Biochem. Biophys. Res. Commun. 2011) 3 4

Products for CADM2 Gene

Sources for CADM2 Gene

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