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CADM1 Gene

protein-coding   GIFtS: 65
GCID: GC11M115044

Cell Adhesion Molecule 1

(Previous names: tumor suppressor in lung cancer 1, immunoglobulin superfamily,...)
(Previous symbols: TSLC1, IGSF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Adhesion Molecule 11 2     Necl-22
IGSF41 2 3 5     RA1752
Tumor Suppressor In Lung Cancer 11 2 3     ST172
TSLC11 2 3     Immunoglobulin Superfamily, Member 4D Variant 12
Immunoglobulin Superfamily, Member 41 2     Immunoglobulin Superfamily, Member 4D Variant 22
Nectin-Like 21 2     sTSLC-12
Immunoglobulin Superfamily Member 42 3     sgIGSF2
Nectin-Like Protein 22 3     synCAM12
Spermatogenic Immunoglobulin Superfamily2 3     Truncated CADM1 Protein2
Synaptic Cell Adhesion Molecule2 3     TSLC1/Nectin-Like 2/IGSF42
IGSF4A2 3     IgSF43
NECL22 3     NECL-23
SYNCAM2 3     SgIgSF3
TSLC-12 3     SynCAM3
BL22     

External Ids:    HGNC: 59511   Entrez Gene: 237052   Ensembl: ENSG000001829857   OMIM: 6056865   UniProtKB: Q9BY673   

Export aliases for CADM1 gene to outside databases

Previous GC identifers: GC11M114551 GC11M110979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CADM1 Gene:
CADM1 (cell adhesion molecule 1) is a protein-coding gene. Diseases associated with CADM1 include asthenopia, and retroperitoneal fibrosis. GO annotations related to this gene include protein C-terminus binding and protein homodimerization activity. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67
Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic
cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in
non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity
and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors
expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast
cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential
for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in
the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration,
axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in
the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their
normal differentiation into mature spermatozoa

Gene Wiki entry for CADM1 (Cell adhesion molecule 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CADM1 gene promoter:
         GATA-3   p53   MyoD   NF-AT   E47   c-Rel   Hand1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCADM1 promoter sequence
   Search Chromatin IP Primers for CADM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CADM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.2

CADM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M115044:  view genomic region     (about GC identifiers)

Start:
115,039,938 bp from pter      End:
115,375,675 bp from pter
Size:
335,738 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67 (See protein sequence)
Recommended Name: Cell adhesion molecule 1 precursor  
Size: 442 amino acids; 48509 Da
Subunit: Homodimer. Interacts with FARP1 (By similarity). Interacts with CRTAM. Interacts (via C-terminus) with
EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via
its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6
Sequence caution: Sequence=AAI25103.1; Type=Frameshift; Positions=1;
2 PDB 3D structures from and Proteopedia for CADM1:
3BIN (3D)        4H5S (3D)    
Secondary accessions: A4FVB5 F5H0J4 H0YGA7 H1ZZV9 H1ZZW1 H1ZZW2 Q86WB8 Q8N2F4
Alternative splicing: 5 isoforms:  Q9BY67-1   Q9BY67-2   Q9BY67-3   Q9BY67-4   Q9BY67-5   

Explore the universe of human proteins at neXtProt for CADM1: NX_Q9BY67

Explore proteomics data for CADM1 at MOPED

Post-translational modifications: 

  • Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction (By similarity)1
  • Glycosylation2 at Asn67, Asn101, Asn113, Asn165, Asn301, Asn302, Asn304, Asn308
  • Modification sites at PhosphoSitePlus

  • See CADM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091987.1  NP_055148.3  

    ENSEMBL proteins: 
     ENSP00000395359   ENSP00000439176   ENSP00000439817   ENSP00000440322   ENSP00000442387  
     ENSP00000329797   ENSP00000442001   ENSP00000439847   ENSP00000439696   ENSP00000442227  
     ENSP00000445375  
    Reactome Protein details: Q9BY67

    CADM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM1 (IGSF4A/SynCAM1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CADM1
    OriGene Protein Over-expression Lysate for CADM1
    OriGene MassSpec for CADM1
    OriGene Custom Protein Services for CADM1
    GenScript Custom Purified and Recombinant Proteins Services for CADM1
    Novus Biologicals CADM1 Proteins
    Novus Biologicals CADM1 Lysates
    Sino Biological Recombinant Protein for CADM1
    Sino Biological Cell Lysate for CADM1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CADM1

    CADM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CADM1
    R&D Systems Antibodies for CADM1 (IGSF4A/SynCAM1)
    OriGene Antibodies for CADM1
    OriGene Custom Antibody Services for CADM1
    Novus Biologicals CADM1 Antibodies
    Search for Antibodies for CADM1 at Abcam
    Cloud-Clone Corp. Antibodies for CADM1
    ThermoFisher Antibody for CADM1
    LSBio Antibodies in human, mouse, rat for CADM1

    CADM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CADM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CADM1
    Cloud-Clone Corp. CLIAs for CADM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9BY67

    ProtoNet protein and cluster: Q9BY67

    3 Blocks protein domains:
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67
    Domain: The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in
    NSCLC
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CADM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADM1_HUMAN, Q9BY67
    Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic
    cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in
    non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity
    and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors
    expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast
    cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential
    for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in
    the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration,
    axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in
    the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their
    normal differentiation into mature spermatozoa

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS12826663
    GO:0005515protein binding IPI12234973
    GO:0008022protein C-terminus binding ISS12826663
    GO:0030165PDZ domain binding ISS12826663
    GO:0042803protein homodimerization activity ISS12826663
         
    CADM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CADM1:
     Decreased cell number and incr 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cadm1):
     endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system  nervous system 
     normal  reproductive system  skeleton 

    CADM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CADM1: Cadm1tm1Momo Cadm1tm1.2Brd Cadm1tm1Mrkm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CADM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CADM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CADM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CADM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CADM1:
    hsa-mir-15a-5p (MIRT003888), hsa-mir-877-3p (MIRT036901), hsa-mir-192-5p (MIRT004167), hsa-mir-16-5p (MIRT004382), hsa-mir-484 (MIRT042379), hsa-mir-26b-5p (MIRT029576)

    Block miRNA regulation of human, mouse, rat CADM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM1 (see all 68):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-605 hsa-miR-3653 hsa-miR-548a-5p hsa-miR-200b hsa-miR-192* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidCADM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CADM1
    Predesigned siRNA for gene silencing in human, mouse, rat CADM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CADM1

    Clone
    Products:
         
    OriGene clones in human, mouse for CADM1 (see all 16)
    OriGene ORF clones in mouse, rat for CADM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM1 (NM_014333)
    Sino Biological Human cDNA Clone for CADM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CADM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CADM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADM1_HUMAN, Q9BY67: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse (By similarity).
    Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of
    epithelial cells in gall bladder
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ISS12826663
    GO:0008021synaptic vesicle IEA--
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane ISS12826663

    CADM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CADM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Adherens junctions interactions0.49
    Cell-cell junction organization0.70
    Nectin/Necl trans heterodimerization0.00
    Cell-Cell communication0.64
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CADM1
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization


    1 Kegg Pathway  (Kegg details for CADM1):
        Cell adhesion molecules (CAMs)


    CADM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CADM1: 
              Lung Cancer in human mouse rat
              Leukemia in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CADM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CADM1 (Q9BY672, 3 ENSP000003297974) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61920 I2D: score=3 
    CASKO149363, ENSP000003674084I2D: score=3 STRING: ENSP00000367408
    MPP3Q133683, ENSP000003814254I2D: score=3 STRING: ENSP00000381425
    SDCBPO005603, ENSP000002601304I2D: score=2 STRING: ENSP00000260130
    EPB41L3Q9Y2J23, ENSP000003411384I2D: score=3 STRING: ENSP00000341138
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001913NOT T cell mediated cytotoxicity IDA15811952
    GO:0006915apoptotic process IEA--
    GO:0007155cell adhesion ----
    GO:0007156homophilic cell adhesion ISS12826663

    CADM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CADM1

    1 Novoseek inferred chemical compound relationship for CADM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 77.7 5 15382043 (1), 12432281 (1), 19014694 (1), 17260099 (1) (see all 5)



    CADM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CADM1 gene (2 alternative transcripts): 
    NM_001098517.1  NM_014333.3  

    Unigene Cluster for CADM1:

    Cell adhesion molecule 1
    Hs.370510  [show with all ESTs]
    Unigene Representative Sequence: BX641042
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000545960 ENST00000452722 ENST00000537140(uc001ppf.4 uc001ppl.3)
    ENST00000542447(uc001ppi.4 uc001ppk.4 uc001ppj.4) ENST00000537058(uc001pph.4)
    ENST00000536727 ENST00000545380 ENST00000331581 ENST00000546000 ENST00000543375
    ENST00000540852 ENST00000441886 ENST00000541434 ENST00000540373 ENST00000542450
    ENST00000543540 ENST00000545094 ENST00000543249
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CADM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CADM1 (see all 68):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-605 hsa-miR-3653 hsa-miR-548a-5p hsa-miR-200b hsa-miR-192* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidCADM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CADM1
    Predesigned siRNA for gene silencing in human, mouse, rat CADM1
    Clone
    Products:
         
    OriGene clones in human, mouse for CADM1 (see all 16)
    OriGene ORF clones in mouse, rat for CADM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM1 (NM_014333)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CADM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CADM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CADM1
      QuantiTect SYBR Green Assays in human, mouse, rat CADM1
      QuantiFast Probe-based Assays in human, mouse, rat CADM1

    Additional mRNA sequence: 

    AB094146.1 AF132811.1 AK023357.1 AK075502.1 AK172730.1 AK315245.1 AL080181.1 AY309502.1 
    AY358334.1 BC035930.1 BC047021.1 BC125102.1 BC125103.1 BX641042.1 BX647110.1 CR457157.1 
    HE586496.1 HE586497.1 HE586498.1 HE586499.1 HE586500.1 HE586501.1 HE586502.1 HE586503.1 

    24 DOTS entries:

    DT.95101401  DT.97810879  DT.454149  DT.100823630  DT.95101406  DT.100823634  DT.207114  DT.99987008 
    DT.100038413  DT.100823641  DT.120742918  DT.102843277  DT.100038414  DT.100823631  DT.120743006  DT.120743012 
    DT.431425  DT.92024403  DT.95346824  DT.97859681  DT.120742946  DT.40132886  DT.92045226  DT.97859683 

    Selected AceView cDNA sequences (see all 445):

    AI659489 AI041631 AA722174 BI553374 BM709588 AA341927 BM709609 T39504 
    BP370399 BP368062 BE503058 BF060771 BQ271248 BM310267 AI376298 BI493685 
    T82323 BF792657 BI915307 BU154175 BF969635 BC047021 BM720417 BM698736 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CADM1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:        -                             -                       -     -           -     -           -                                 
    SP2:        -                             -                       -           -     -     -     -     -                                 
    SP3:        -                             -                                                                                             
    SP4:                                                                                -     -     -     -                                 
    SP5:                                                                                      -     -     -                                 


    ECgene alternative splicing isoforms for CADM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CADM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATACCATTT
    CADM1 Expression
    About this image


    CADM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Gonad
             XY Germ Cells Testis Cord
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    CADM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CADM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370510
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CADM1: 
              Lung Cancer in human mouse rat
              Leukemia in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Lymphoma in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CADM1
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    QuantiFast Probe-based Assays in human, mouse, rat CADM1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CADM1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cadm11 , 5 cell adhesion molecule 11, 5 92.76(n)1
    98.64(a)1
      9 (25.83 cM)5
    547251  NM_018770.31  NP_061240.31 
     475301735 
    chicken
    (Gallus gallus)
    Aves CADM11 cell adhesion molecule 1 80.7(n)
    84.46(a)
      419762  XM_417901.4  XP_417901.4 
    lizard
    (Anolis carolinensis)
    Reptilia CADM16
    cell adhesion molecule 1
    74(a)
    1 ↔ 1
    GL343472.1(420716-492146)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148582 Xenopus laevis transcribed sequence with weak similarity more 79.22(n)    CD300961.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cadm1b1 cell adhesion molecule 1b 68.39(n)
    70.03(a)
      562183  NM_001113552.1  NP_001107024.1 


    ENSEMBL Gene Tree for CADM1 (if available)
    TreeFam Gene Tree for CADM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CADM1 gene
    CADM42  CADM32  CRTAM2  CADM22  
    7 SIMAP similar genes for CADM1 using alignment to 11 protein entries:     CADM1_HUMAN (see all proteins):
    DKFZp686F1789    RRM1    C19orf47    CADM4    CADM2    GYPC
    CADM3

    CADM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CADM1 (see all 6006)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814222671,2
    C--115043865(+) TTCTTA/C/TTTATG 2 -- int10--------
    rs108918021,2
    C,F,A,H--115043888(+) ACTTTA/CAAGGA 2 -- int126Minor allele frequency- N:0.00EA NA NS WA CSA 2604
    rs1413618811,2
    --115043919(+) AAGACA/GCAAAC 2 -- int10--------
    rs1841476161,2
    --115044005(+) GAGTGC/TGGAAG 2 -- int10--------
    rs79503621,2
    C,H--115044018(+) ACATCC/TACGGG 2 -- int113Minor allele frequency- T:0.01NA WA CSA EA 375
    rs112153971,2
    C,F,A,H--115044076(+) AAATCG/ACTGAG 2 -- int113Minor allele frequency- A:0.30NA NS WA CSA EA 552
    rs1177922061,2
    C,F--115044087(+) TCCACG/ATGGGA 2 -- int11Minor allele frequency- A:0.02EA 120
    rs455001911,2
    C--115044090(+) ACGTGG/AGAGCC 2 -- int13Minor allele frequency- A:0.03NS NA 162
    rs1450913941,2
    C--115044111(+) CACGGC/TACAGC 2 -- int10--------
    rs44501971,2
    C,A,H--115044211(+) CCAGCT/CGGCAG 2 -- int110Minor allele frequency- C:0.11NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for CADM1 (115039938 - 115289938 bp, first 250kb of CADM1)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CADM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659168CNV Deletion23128226
    esv1078257CNV Insertion17803354
    nsv502CNV Insertion18451855
    nsv525753CNV Loss19592680
    nsv468871CNV Loss19166990
    esv7788CNV Gain19470904
    nsv832278CNV Gain17160897

    Human Gene Mutation Database (HGMD): CADM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CADM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605686    OMIM disorders: --

    Selected diseases for CADM1 (see all 63):    
    About MalaCards
    asthenopia    retroperitoneal fibrosis    facial paralysis    lung cancer
    autoimmune pancreatitis    cervical cancer    cervical intraepithelial neoplasia    adenosquamous carcinoma
    cervicitis    neurofibromatosis    adult t-cell leukemia    cardiovascular disease risk factor
    pandas    nasopharyngitis    autoimmune hepatitis    malignant pleural mesothelioma
    meningioma    venous thrombosis    laryngeal squamous cell carcinoma    acute pancreatitis

    4 diseases from the University of Copenhagen DISEASES database for CADM1:
    Asthenopia     Atherosclerosis     Facial paralysis     Lymphoma

    CADM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CADM1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 64.3 38 12925956 (5), 12920246 (4), 16205641 (4), 12362275 (3) (see all 14)
    adenocarcinoma lung 62.3 8 16108829 (5), 14559819 (1), 12942568 (1)
    cancer lung 60.4 29 13679854 (2), 16083501 (2), 12234973 (2), 12799182 (2) (see all 19)
    lung tumor 56.3 6 12234973 (2), 14659875 (1), 13679854 (1), 12925956 (1) (see all 5)
    neurofibromatosis type 2 54.9 2 15542977 (1), 19429976 (1)
    tumors 52.2 140 12920246 (5), 13679854 (5), 19429976 (5), 16083501 (4) (see all 43)
    allelic loss 52.2 3 12973698 (1), 15382043 (1), 14970278 (1)
    meningioma 43.6 16 15535129 (7), 19429976 (5), 17130425 (1)
    invasive cervical cancer 43.1 2 17009984 (1), 14970278 (1)
    lung carcinoma 40.9 4 16205641 (2), 15811952 (1), 12942568 (1)

    Genetic Association Database (GAD): CADM1
    Human Genome Epidemiology (HuGE) Navigator: CADM1 (7 documents)

    Export disorders for CADM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CADM1 gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with CADM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. (PubMed id 12920246)1, 2, 9 Ito A.... Kitamura Y. (Lab. Invest. 2003)
    2. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. (PubMed id 12925956)1, 2, 9 Fukami T.... Murakami Y. (Int. J. Cancer 2003)
    3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)1, 2, 9 Galibert L.... Yan W. (J. Biol. Chem. 2005)
    4. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. (PubMed id 15184878)1, 2, 9 Mao X.... Ghosh H.P. (Oncogene 2004)
    5. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)1, 2, 9 Fukuhara H.... Murakami Y. (Oncogene 2003)
    6. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PubMed id 12234973)1, 2, 9 Yageta M.... Murakami Y. (Cancer Res. 2002)
    7. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. (PubMed id 11279526)1, 2, 9 Kuramochi M.... Murakami Y. (Nat. Genet. 2001)
    8. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)1, 2, 9 Boles K.S.... Colonna M. (Blood 2005)
    9. A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. (PubMed id 10610705)1, 3, 9 Gomyo H....Ohki M. (Genomics 1999)
    10. CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion. (PubMed id 22438059)1, 2 Moiseeva E.P.... Bradding P. (Cell. Mol. Life Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23705 HGNC: 5951 AceView: IGSF4 Ensembl:ENSG00000182985 euGenes: HUgn23705
    ECgene: CADM1 Kegg: 23705 H-InvDB: CADM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CADM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CADM1 gene:
    Search GeneIP for patents involving CADM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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