Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CADM1 Gene

protein-coding   GIFtS: 64
GCID: GC11M115044

cell adhesion molecule 1

(Previous names: tumor suppressor in lung cancer 1, immunoglobulin superfamily,...)
(Previous symbols: TSLC1, IGSF4)
 Explore 53 diseases affiliated with
CADM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CADM1    

Aliases
for CADM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Adhesion Molecule 11 2     Synaptic Cell Adhesion Molecule2 3
IGSF41 2 3 5     TSLC-12 3
Tumor Suppressor In Lung Cancer 11 2 3     SYNCAM11
IGSF4A1 2 3     Immunoglobulin Superfamily, Member 4D Variant 22
NECL21 2 3     Nectin-Like 22
SYNCAM1 2 3     STSLC-11
TSLC11 2 3     SgIGSF1
BL21 2     SynCAM11
Necl-21 2     Truncated CADM1 Protein2
RA1751 2     TSLC1/Nectin-Like 2/IGSF42
ST171 2     IgSF43
Immunoglobulin Superfamily, Member 41 2     NECL-23
Immunoglobulin Superfamily Member 42 3     SgIgSF3
Nectin-Like Protein 22 3     SynCAM3
Spermatogenic Immunoglobulin Superfamily2 3     

External Ids:    HGNC: 59511   Entrez Gene: 237052   Ensembl: ENSG000001829857   OMIM: 6056865   UniProtKB: Q9BY673   

Export aliases for CADM1 gene to outside databases

Previous GC identifers: GC11M114551 GC11M110979


Summaries
for CADM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67
Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell
adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer
(NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May
contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and
promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells
in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal
migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles
in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal
differentiation into mature spermatozoa

Gene Wiki entry for CADM1 (Cell adhesion molecule 1)


Genomic Views
for CADM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CADM1 gene promoter:
         GATA-3   p53   MyoD   NF-AT   E47   c-Rel   Hand1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CADM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CADM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.2

CADM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CADM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M115044:  view genomic region     (about GC identifiers)

Start:
 115,039,938 bp from pter      End:
 115,375,675 bp from pter
Size:
 335,738 bases      Orientation:
 minus strand

Proteins
for CADM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67 (See protein sequence)
Recommended Name: Cell adhesion molecule 1 precursor  
Size: 442 amino acids; 48509 Da
Subunit: Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to
the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse (By similarity).
Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of
epithelial cells in gall bladder
1 PDB 3D structure from and Proteopedia for CADM1:
3BIN (3D)    
Secondary accessions: Q86WB8 Q8N2F4
Alternative splicing: 2 isoforms:  Q9BY67-1   Q9BY67-2   

Explore the universe of human proteins at neXtProt for CADM1: NX_Q9BY67

Post-translational modifications:

  • Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BY67

    • CADM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091987.1  NP_055148.3  

    ENSEMBL proteins: 
     ENSP00000439176   ENSP00000395359   ENSP00000439817   ENSP00000440322   ENSP00000442387  
     ENSP00000329797   ENSP00000442001   ENSP00000439847   ENSP00000439696   ENSP00000442227  
     ENSP00000445375  
    Reactome Protein details: Q9BY67
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CADM1 (IGSF4A/SynCAM1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CADM1
    OriGene Protein Over-expression Lysate: CADM1
    OriGene Custom Protein Services for CADM1 
    GenScript Custom Purified and Recombinant Proteins Services for CADM1
    Novus Biologicals CADM1 Proteins
    Novus Biologicals CADM1 Lysates
    Sino Biological Recombinant Protein for CADM1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CADM1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ISS12826663
    GO:0008021synaptic vesicle IEA--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane ISS12826663


    CADM1 for ontologies           About GeneDecksing



    CADM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CADM1
    R&D Systems Antibodies for CADM1 (IGSF4A/SynCAM1)
    OriGene Antibodies: CADM1
    OriGene Custom Antibody Services for CADM1 
    GenScript Custom Superior Antibodies Services for CADM1
    Novus Biologicals CADM1 Antibodies
    Search for Antibodies for CADM1 at Abcam  
    Uscn Antibodies for CADM1
    ThermoFisher Antibody for CADM1

    Assay Products for CADM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CADM1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CADM1

    Protein Domains /
    Families
    for CADM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CADM1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY67

    ProtoNet protein and cluster: Q9BY67

    3 Blocks protein families:
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67
    Domain: The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for CADM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CADM1_HUMAN, Q9BY67
    Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell
    adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer
    (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
    secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May
    contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and
    promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells
    in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal
    migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles
    in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal
    differentiation into mature spermatozoa

    miRNA
    Products:            		miRTarBase miRNAs that target CADM1:
    hsa-mir-192 (MIRT004167)

    OriGene 3'-UTR Clone (see all 2): CADM1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM1
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM1 (see all 68):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-605 hsa-miR-3653 hsa-miR-548a-5p hsa-miR-200b hsa-miR-192* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: CADM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM1 (see all 7)
    OriGene shRNA RFP: CADM1
    OriGene siRNA: CADM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CADM1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM1 (NM_014333)
    Sino Biological Human cDNA Clone for CADM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CADM1
    Search LifeMap BioReagents cell lines for CADM1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS12826663
    GO:0005515protein binding IPI12234973
    GO:0008022protein C-terminus binding ISS12826663
    GO:0030165PDZ domain binding ISS12826663
    GO:0042803protein homodimerization activity ISS12826663


    CADM1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CADM1:
     Decreased cell number and incr 

    Animal Models:
         Mouse knock-outs for CADM1: Cadm1tm1Momo Cadm1tm1.2Brd Cadm1tm1Mrkm
         9 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Cadm1):
     cellular  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     nervous system  normal  reproductive system  skeleton 

    CADM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CADM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Adherens junctions interactions0.51
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Nectin/Necl trans heterodimerization
    		Nectin/Necl trans heterodimerization1.00
    3Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for CADM1
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    1         Kegg Pathway  (Kegg details for CADM1):
        Cell adhesion molecules (CAMs)


    CADM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CADM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CADM1 (Q9BY672, 3 ENSP000003297974) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61920 I2D: score=3 
    CASKO149363, ENSP000003674084I2D: score=3 STRING: ENSP00000367408
    MPP3Q133683, ENSP000003814254I2D: score=3 STRING: ENSP00000381425
    SDCBPO005603, ENSP000002601304I2D: score=2 STRING: ENSP00000260130
    EPB41L3Q9Y2J23, ENSP000003411384I2D: score=3 STRING: ENSP00000341138
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001913NOT T cell mediated cytotoxicity IDA15811952
    GO:0006915apoptotic process IEA--
    GO:0007155cell adhesion ----
    GO:0007156homophilic cell adhesion ISS12826663


    CADM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CADM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CADM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CADM1
    1 Novoseek chemical compound relationship for CADM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 77.7 5 15382043 (1), 12432281 (1), 19014694 (1), 17260099 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CADM1 

    Transcripts
    for CADM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CADM1 gene (2 alternative transcripts): 
    NM_001098517.1  NM_014333.3  

    Unigene Cluster for CADM1:

    Cell adhesion molecule 1
    Hs.370510  [show with all ESTs]
    Unigene Representative Sequence: BX641042
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000545960 ENST00000537140(uc001ppf.4 uc001ppl.3) ENST00000542447(uc001ppi.4 uc001ppk.4 uc001ppj.4)
    ENST00000452722 ENST00000537058(uc001pph.4) ENST00000536727 ENST00000545380
    ENST00000331581 ENST00000546000 ENST00000543375 ENST00000540852 ENST00000441886
    ENST00000541434 ENST00000540373 ENST00000542450 ENST00000543540 ENST00000545094
    ENST00000543249

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CADM1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CADM1
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CADM1 (see all 68):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-605 hsa-miR-3653 hsa-miR-548a-5p hsa-miR-200b hsa-miR-192* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: CADM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM1 (see all 7)
    OriGene shRNA RFP: CADM1
    OriGene siRNA: CADM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CADM1 (NM_014333)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CADM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CADM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CADM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM1

    Additional cDNA sequence: 

    AB075480.1 AB094146.1 AF132811.1 AK023357.1 AK075502.1 AK172730.1 AK315245.1 AL080181.1 
    AY309502.1 AY358334.1 BC035930.1 BC047021.1 BC125102.1 BC125103.1 BX641042.1 BX647110.1 
    CR457157.1 HE586496.1 HE586497.1 HE586498.1 HE586499.1 HE586500.1 HE586501.1 HE586502.1 
    HE586503.1 

    24/26 DOTS entries (see all 26):

    DT.95101401  DT.97810879  DT.454149  DT.100823630  DT.95101406  DT.100823634  DT.207114  DT.99987008 
    DT.100038413  DT.100823641  DT.120742918  DT.120742978  DT.102843277  DT.100038414  DT.100823631  DT.102843275 
    DT.120743006  DT.120743012  DT.431425  DT.92024403  DT.95346824  DT.97859681  DT.120742946  DT.40132886 

    24/445 AceView cDNA sequences (see all 445):

    AI659489 AA722174 AI041631 BI553374 BM709588 AA341927 T39504 BM709609 
    BP368062 BP370399 BE503058 BF060771 BQ271248 BM310267 T82323 AI376298 
    BI493685 BU154175 BF792657 BI915307 BF969635 BC047021 BM720417 BM698736 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CADM1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:        -                             -                       -     -           -     -           -                                 
    SP2:        -                             -                       -           -     -     -     -     -                                 
    SP3:        -                             -                                                                                             
    SP4:                                                                                -     -     -     -                                 
    SP5:                                                                                      -     -     -                                 


    ECgene alternative splicing isoforms for CADM1

    Expression
    for CADM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CADM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATACCATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CADM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Muscle Satellite PoolForelimb Muscle Satellite CellsSkeletal Muscle
    LimbHindlimb Muscle Satellite PoolHindlimb Muscle Satellite CellsSkeletal Muscle
    Skeletal MuscleCervical Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleLumbar Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleSacral Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleThoracic Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    CartilageMeckel's CartilageCartilage
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See CADM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CADM1

    SOURCE GeneReport for Unigene cluster: Hs.370510
        SABiosciences Expression via Pathway-Focused PCR Arrays including CADM1: 
              Lung Cancer in human mouse rat
              Leukemia in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CADM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CADM1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM1

    Orthologs
    for CADM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CADM1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CADM11 cell adhesion molecule 1 80.87(n)
    84.46(a)    		   419762  XM_417901.3  XP_417901.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CADM16
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343472.1(420716-487336)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.148582 Xenopus laevis transcribed sequence with weak similarity more 79.22(n)    CD300961.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cadm1b1 cell adhesion molecule 1b 67.28(n)
    68.15(a)    		   562183  NM_001113552.1  NP_001107024.1 


    ENSEMBL Gene Tree for CADM1 (if available)
    TreeFam Gene Tree for CADM1 (if available) 

    Paralogs
    for CADM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CADM1 gene
    CADM42  PVR2  CRTAM2  PVRL42  PVRL32  CADM32  PVRL22  CADM22  
    PVRL12  
    9 SIMAP similar genes for CADM1 using alignment to 17 protein entries:     CADM1_HUMAN (see all proteins):
    DKFZp686F1789    RRM1    C19orf47    CNTNAP2    CADM2    CADM4
    GYPC    CADM3    MUSK

    CADM1 for paralogs           About GeneDecksing



    Genomic Variants
    for CADM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5351 NCBI SNPs in CADM1 are shown (see all 5351)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1814222671,2
    		--115043865(+) TTCTTC/TTTATG 2 -- int10--------
    rs108918021,2
    		C,F,A,H,--115043888(+) ACTTTA/CAAGGA 2 -- int126Minor allele frequency- N:0.00EA NA NS WA CSA 2604
    rs1413618811,2
    		--115043919(+) AAGACA/GCAAAC 2 -- int10--------
    rs1841476161,2
    		--115044005(+) GAGTGC/TGGAAG 2 -- int10--------
    rs79503621,2
    		C,H,--115044018(+) ACATCC/TACGGG 2 -- int113Minor allele frequency- T:0.01NA WA CSA EA 375
    rs112153971,2
    		C,F,A,H,--115044076(+) AAATCG/ACTGAG 2 -- int113Minor allele frequency- A:0.30NA NS WA CSA EA 552
    rs1177922061,2
    		C,F,--115044087(+) TCCACG/ATGGGA 2 -- int11Minor allele frequency- A:0.02EA 120
    rs455001911,2
    		C,--115044090(+) NNNNGG/AGAGCC 2 -- int13Minor allele frequency- A:0.03NS NA 162
    rs1450913941,2
    		--115044111(+) CACGGC/TACAGC 2 -- int10--------
    rs44501971,2
    		C,A,H,--115044211(+) CCAGCT/CGGCAG 2 -- int110Minor allele frequency- C:0.11NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for CADM1 (115039938 - 115289938 bp, first 250kb of CADM1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CADM1
         1 Indel: 60065
    Human Gene Mutation Database (HGMD): CADM1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CADM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CADM1

    Disorders / Diseases
    for CADM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CADM1 for disorders           About GeneDecksing

    OMIM gene information: 605686    OMIM disorders: --

    20/53 diseases for CADM1 (see all 53):    About MalaCards
    lung cancer    cervical intraepithelial neoplasia    malignant pleural mesothelioma    facial paralysis
    autism spectrum disorder    retroperitoneal fibrosis    asthenopia    esophageal squamous cell carcinoma
    squamous cell carcinoma    pancreatic ductal adenocarcinoma    adult t-cell leukemia    cervicitis
    chronic lymphocytic leukemia    acute myeloid leukemia    lymphocytic leukemia    burkitt's lymphoma
    neurofibromatosis    myeloid leukemia    cervical cancer    cervical carcinoma

    4 diseases from the University of Copenhagen DISEASES database for CADM1:
    Atherosclerosis     Facial paralysis     Asthenopia     Lung cancer

    10/25 Novoseek disease relationships for CADM1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 64.3 38 12925956 (5), 12920246 (4), 16205641 (4), 12362275 (3) (see all 14)
    adenocarcinoma lung 62.3 8 16108829 (5), 14559819 (1), 12942568 (1)
    cancer lung 60.4 29 13679854 (2), 16083501 (2), 12234973 (2), 12799182 (2) (see all 19)
    lung tumor 56.3 6 12234973 (2), 14659875 (1), 13679854 (1), 12925956 (1) (see all 5)
    neurofibromatosis type 2 54.9 2 15542977 (1), 19429976 (1)
    tumors 52.2 140 12920246 (5), 13679854 (5), 19429976 (5), 16083501 (4) (see all 43)
    allelic loss 52.2 3 12973698 (1), 15382043 (1), 14970278 (1)
    meningioma 43.6 16 15535129 (7), 19429976 (5), 17130425 (1)
    invasive cervical cancer 43.1 2 17009984 (1), 14970278 (1)
    lung carcinoma 40.9 4 16205641 (2), 15811952 (1), 12942568 (1)

    Human Genome Epidemiology (HuGE) Navigator: CADM1 (7 documents)

    Export disorders for CADM1 gene to outside databases

    Publications
    for CADM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CADM1 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with CADM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. (PubMed id 12920246)1, 2, 9 Ito A.... Kitamura Y. (2003)
    2. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. (PubMed id 12925956)1, 2, 9 Fukami T.... Murakami Y. (2003)
    3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)1, 2, 9 Galibert L.... Yan W. (2005)
    4. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. (PubMed id 15184878)1, 2, 9 Mao X.... Ghosh H.P. (2004)
    5. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)1, 2, 9 Fukuhara H.... Murakami Y. (2003)
    6. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PubMed id 12234973)1, 2, 9 Yageta M.... Murakami Y. (2002)
    7. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. (PubMed id 11279526)1, 2, 9 Kuramochi M.... Murakami Y. (2001)
    8. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)1, 2, 9 Boles K.S.... Colonna M. (2005)
    9. A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. (PubMed id 10610705)1, 3, 9 Gomyo H....Ohki M. (1999)
    10. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. (PubMed id 15905536)1, 2 Furuno T.... Kitamura Y. (2005)

    External Searches for CADM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CADM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23705 HGNC: 5951 AceView: IGSF4 Ensembl:ENSG00000182985 euGenes: HUgn23705
    ECgene: CADM1 Kegg: 23705 H-InvDB: CADM1

    Other Databases showing CADM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CADM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CADM1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CADM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CADM1 gene:
    Search GeneIP for patents involving CADM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CADM1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CADM1
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CADM1 (IGSF4A/SynCAM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CADM1 (IGSF4A/SynCAM1)  
     OriGene Antibodies for CADM1   OriGene shRNA RFP for CADM1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CADM1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CADM1  
     OriGene Protein Over-expression Lysate for CADM1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CADM1   OriGene 3'-UTR Clone for CADM1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CADM1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CADM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CADM1   OriGene Custom Protein Services for CADM1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CADM1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CADM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CADM1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CADM1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CADM1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CADM1
     GenScript Custom Purified and Recombinant Proteins Services for CADM1 GenScript cDNA clones with any tag delivered in your preferred vector for CADM1
     GenScript Custom Assay Services for CADM1 GenScript Custom Superior Antibodies Services for CADM1
     GenScript Custom overexpressing Cell Line Services for CADM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CADM1 promoter
     Search Chromatin IP Primers for CADM1
     RT2 qPCR Primer Assay in human, mouse, rat CADM1
     GNC Network for CADM1
     SABiosciences PCR Arrays including human, mouse, rat CADM1
     Search Tocris compounds for CADM1
     Proteins and Antibodies for CADM1
     cDNA Clones for CADM1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CADM1 antibodies
     CADM1 proteins
     CADM1 lysates
     Search for Antibodies for CADM1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CADM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CADM1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CADM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CADM1
     SwitchGear 3'UTR luciferase reporter plasmids for CADM1
     SwitchGear Promoter luciferase reporter plasmids for CADM1
     ThermoFisher Antibody for CADM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CADM1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CADM1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4