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Aliases for CADM1 Gene

Aliases for CADM1 Gene

  • Cell Adhesion Molecule 1 2 3 5
  • Tumor Suppressor In Lung Cancer 1 2 3 4
  • Spermatogenic Immunoglobulin Superfamily 3 4
  • Immunoglobulin Superfamily Member 4 3 4
  • Synaptic Cell Adhesion Molecule 3 4
  • Nectin-Like Protein 2 3 4
  • Nectin-Like 2 2 3
  • Necl-2 3 4
  • SgIGSF 3 4
  • IGSF4A 3 4
  • SYNCAM 3 4
  • TSLC-1 3 4
  • IGSF4 3 4
  • TSLC1 3 4
  • NECL2 3 4
  • Immunoglobulin Superfamily, Member 4D Variant 1 3
  • Immunoglobulin Superfamily, Member 4D Variant 2 3
  • Immunoglobulin Superfamily, Member 4 2
  • TSLC1/Nectin-Like 2/IGSF4 3
  • Truncated CADM1 Protein 3
  • STSLC-1 3
  • SynCAM1 3
  • RA175 3
  • ST17 3
  • BL2 3

External Ids for CADM1 Gene

Previous HGNC Symbols for CADM1 Gene

  • TSLC1
  • IGSF4

Previous GeneCards Identifiers for CADM1 Gene

  • GC11M114551
  • GC11M115044
  • GC11M110979

Summaries for CADM1 Gene

GeneCards Summary for CADM1 Gene

CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Retroperitoneal Fibrosis and Lung Cancer. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). GO annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.

UniProtKB/Swiss-Prot for CADM1 Gene

  • Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Gene Wiki entry for CADM1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM1 Gene

Genomics for CADM1 Gene

Regulatory Elements for CADM1 Gene

Enhancers for CADM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G115206 0.8 ENCODE 41.6 +297.3 297339 1.5 FOXA2 ARID4B THRB RAD21 RARA CREM MIXL1 ZNF263 HMG20B PRDM6 CADM1 PIR31191 GC11P115179
GH11G115220 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +282.8 282843 3.4 TBL1XR1 JUN ASH2L RELA ARID3A CBX5 EED SCRT2 FOS ETV6 CADM1 PIR31191 GC11P115179
GH11G115226 0.8 ENCODE dbSUPER 20 +277.7 277695 1.9 JUND TEAD4 HLF EP300 MAFK TEAD3 CADM1 PIR31191 GC11P115179
GH11G115621 1.1 Ensembl ENCODE 12.2 -117.9 -117925 1.8 FOXA2 INSM2 RAD21 GLIS2 FOS CREM ZEB2 NR2F2 NFIL3 SMARCA4 CADM1 ENSG00000239153 ENSG00000255689
GH11G115548 1.1 Ensembl ENCODE 11.1 -44.1 -44100 0.7 ELF3 FOXA2 ARID4B DMAP1 RAD21 ZNF143 CREM EGR2 SP5 CEBPA CADM1 FTLP7 RPL12P46
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CADM1 on UCSC Golden Path with GeneCards custom track

Promoters for CADM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045309 757 2401 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 SP3 ZHX2

Genomic Location for CADM1 Gene

Chromosome:
11
Start:
115,169,218 bp from pter
End:
115,504,957 bp from pter
Size:
335,740 bases
Orientation:
Minus strand

Genomic View for CADM1 Gene

Genes around CADM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM1 Gene

Proteins for CADM1 Gene

  • Protein details for CADM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY67-CADM1_HUMAN
    Recommended name:
    Cell adhesion molecule 1
    Protein Accession:
    Q9BY67
    Secondary Accessions:
    • A4FVB5
    • F5H0J4
    • H0YGA7
    • H1ZZV9
    • H1ZZW1
    • H1ZZW2
    • Q86WB8
    • Q8N2F4
    • X5D2C8

    Protein attributes for CADM1 Gene

    Size:
    442 amino acids
    Molecular mass:
    48509 Da
    Quaternary structure:
    • Homodimer. Interacts with FARP1 (By similarity). Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP2, MPP3 and MPP6.
    SequenceCaution:
    • Sequence=AAI25103.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADM1 Gene

    Alternative splice isoforms for CADM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM1 Gene

Post-translational modifications for CADM1 Gene

  • Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.
  • Glycosylation at posLast=6767, Asn101, Asn113, posLast=165165, posLast=301301, Asn302, posLast=304304, and Asn308
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CADM1 (IGSF4A/SynCAM1)

Protein Products

No data available for DME Specific Peptides for CADM1 Gene

Domains & Families for CADM1 Gene

Suggested Antigen Peptide Sequences for CADM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY67

UniProtKB/Swiss-Prot:

CADM1_HUMAN :
  • The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
  • Belongs to the nectin family.
Domain:
  • The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM1: view

Function for CADM1 Gene

Molecular function for CADM1 Gene

UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Gene Ontology (GO) - Molecular Function for CADM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding ISS 12826663
GO:0005515 protein binding IPI 12234973
GO:0030165 PDZ domain binding ISS 12826663
GO:0042803 protein homodimerization activity ISS 12826663
genes like me logo Genes that share ontologies with CADM1: view
genes like me logo Genes that share phenotypes with CADM1: view

Animal Models for CADM1 Gene

MGI Knock Outs for CADM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM1

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADM1 Gene

Localization for CADM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250 UniProtKB:Q8R5M8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CADM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction ISS 12826663
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CADM1: view

Pathways & Interactions for CADM1 Gene

genes like me logo Genes that share pathways with CADM1: view

Gene Ontology (GO) - Biological Process for CADM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 NOT T cell mediated cytotoxicity IDA 15811952
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12826663
genes like me logo Genes that share ontologies with CADM1: view

No data available for SIGNOR curated interactions for CADM1 Gene

Drugs & Compounds for CADM1 Gene

(1) Additional Compounds for CADM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CADM1: view

Transcripts for CADM1 Gene

Unigene Clusters for CADM1 Gene

Cell adhesion molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for CADM1 Gene

GeneLoc Exon Structure for
CADM1
ECgene alternative splicing isoforms for
CADM1

Expression for CADM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CADM1 Gene

mRNA differential expression in normal tissues according to GTEx for CADM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for CADM1 Gene

This gene is overexpressed in Retina (11.8), Serum (9.6), Testis (7.2), Brain (6.5), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CADM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CADM1 Gene:

CADM1

SOURCE GeneReport for Unigene cluster for CADM1 Gene:

Hs.370510

Evidence on tissue expression from TISSUES for CADM1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Pancreas(3.5)
  • Lung(3.4)
  • Eye(3.1)
  • Heart(2.7)
  • Blood(2.4)
  • Muscle(2.1)
  • Kidney(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CADM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CADM1 Gene

Orthologs for CADM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CADM1 34 35
  • 96.61 (n)
cow
(Bos Taurus)
Mammalia CADM1 34 35
  • 93.72 (n)
mouse
(Mus musculus)
Mammalia Cadm1 34 16 35
  • 92.76 (n)
rat
(Rattus norvegicus)
Mammalia Cadm1 34
  • 91.86 (n)
dog
(Canis familiaris)
Mammalia CADM1 34 35
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia CADM1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CADM1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CADM1 34 35
  • 80.7 (n)
lizard
(Anolis carolinensis)
Reptilia CADM1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cadm1 34
  • 66.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14858 34
zebrafish
(Danio rerio)
Actinopterygii cadm1b 34 35
  • 68.39 (n)
cadm1a 35
  • 61 (a)
OneToMany
Species where no ortholog for CADM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM1 Gene

ENSEMBL:
Gene Tree for CADM1 (if available)
TreeFam:
Gene Tree for CADM1 (if available)

Paralogs for CADM1 Gene

Paralogs for CADM1 Gene

genes like me logo Genes that share paralogs with CADM1: view

Variants for CADM1 Gene

Sequence variations from dbSNP and Humsavar for CADM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000003478 -- 115,411,323(+) TCAGG(C/G)CCATT intron-variant
rs1000020827 -- 115,317,274(+) TTAAA(A/G)GGTCA intron-variant
rs1000023878 -- 115,458,682(+) AGTAA(C/T)CACAT intron-variant
rs1000028413 -- 115,280,648(+) TCAAA(A/G)CAGGC intron-variant
rs1000036251 -- 115,366,232(+) AACAG(A/G)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CADM1 Gene

Variant ID Type Subtype PubMed ID
esv1078257 CNV insertion 17803354
esv2659168 CNV deletion 23128226
esv3627810 CNV loss 21293372
esv3627811 CNV loss 21293372
esv3627812 CNV loss 21293372
esv7788 CNV gain 19470904
nsv1042473 CNV loss 25217958
nsv1050802 CNV loss 25217958
nsv1122669 CNV deletion 24896259
nsv1134177 CNV deletion 24896259
nsv1134178 CNV deletion 24896259
nsv1138077 CNV deletion 24896259
nsv468871 CNV loss 19166990
nsv502 CNV insertion 18451855
nsv525753 CNV loss 19592680
nsv556446 CNV loss 21841781
nsv832278 CNV gain 17160897

Variation tolerance for CADM1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CADM1 Gene

Human Gene Mutation Database (HGMD)
CADM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CADM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM1 Gene

Disorders for CADM1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CADM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retroperitoneal fibrosis
  • idiopathic retroperitoneal fibrosis
lung cancer
  • lung cancer, protection against
acute myeloid leukemia with t(9;11)(p22;q23)
  • aml with t(9;11)(p22;q23)
asthenopia
  • accommodative strain
facial nerve disease
  • facial nerve diseases
- elite association - COSMIC cancer census association via MalaCards
Search CADM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CADM1

Genetic Association Database (GAD)
CADM1
Human Genome Epidemiology (HuGE) Navigator
CADM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CADM1
genes like me logo Genes that share disorders with CADM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CADM1 Gene

Publications for CADM1 Gene

  1. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PMID: 15781451) Galibert L. … Yan W. (J. Biol. Chem. 2005) 3 4 22 64
  2. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PMID: 15811952) Boles K.S. … Colonna M. (Blood 2005) 3 4 22 64
  3. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. (PMID: 15184878) Mao X. … Ghosh H.P. (Oncogene 2004) 3 4 22 64
  4. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. (PMID: 12920246) Ito A. … Kitamura Y. (Lab. Invest. 2003) 3 4 22 64
  5. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. (PMID: 12925956) Fukami T. … Murakami Y. (Int. J. Cancer 2003) 3 4 22 64

Products for CADM1 Gene

Sources for CADM1 Gene

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