CAD Gene
protein-coding GIFtS: 66
GCID: GC02P027440
|
|
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase,...
| |
Aliases
for CAD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, AndDihydroorotase1 2 | | EC 2.1.3.28 | | CAD Protein2 | | EC 3.5.2.38 | | CAD Trifunctional Protein2 | | EC 6.3.58 | | Multifunctional Protein CAD2 | | EC 6.3.5.58 |
Export aliases for CAD gene to outside databasesPrevious GC identifers: GC02P027361 GC02P027532 GC02P027414 GC02P027351 GC02P027181 |
Summaries
for CAD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAD:
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes atrifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathwayof pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase.This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct linkbetween activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: PYR1_HUMAN, P27708Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase,CPSase, ATCase and DHOase)
|
Genomic Views
for CAD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAD gene promoter:
PPAR-gamma1 AP-1 ATF-2 MyoD c-Jun PPAR-gamma2 CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22-p21 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p22-p21CAD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P027440: view genomic region
(about GC identifiers)
Start:
|
27,440,258 bp from pter |
End:
|
27,466,660 bp from pter |
Size:
|
26,403 bases |
Orientation:
|
plus strand |
|
Proteins
for CAD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PYR1_HUMAN, P27708 (See
protein sequence)Recommended Name: CAD protein Size: 2225 amino acids; 242984 Da
Cofactor: Binds 1 zinc ion per subunit (for dihydroorotase activity) (Potential)
Subunit: Homohexamer
Subcellular location: Cytoplasm
Miscellaneous: GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together theglutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5)
Secondary accessions: D6W552 Q6P0Q0Explore the universe of human proteins at neXtProt for CAD: NX_P27708
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P27708
4/15 DME Specific Peptides for CAD (P27708) (see all 15)
CAD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004332.2
ENSEMBL proteins: ENSP00000264705 ENSP00000384510 ENSP00000414742 ENSP00000388740 ENSP00000405416 Reactome Protein details: P27708
Human Recombinant Protein Products for CAD:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CAD for ontologies About GeneDecksing
CAD Antibody Products:
Assay Products for CAD: |
Protein
Domains /
Families
for CAD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAD for domains About GeneDecksing
5/19 InterPro domains/families (see all 19):Graphical View of Domain Structure for InterPro Entry P27708ProtoNet protein and cluster: P27708 5/7 Blocks protein families (see all 7): IPB000991 Glutamine amidotransferase class-I IPB001317 Carbamoyl-phosphate synthase protein GATase domain signature IPB002082 Aspartate carbamoyltransferase signature IPB002195 Dihydroorotase IPB002474 Carbamoyl-phosphate synthase
UniProtKB/Swiss-Prot: PYR1_HUMAN, P27708Similarity: In the central section; belongs to the DHOase familySimilarity: Contains 2 ATP-grasp domainsSimilarity: Contains 1 glutamine amidotransferase type-1 domain |
Function
for CAD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PYR1_HUMAN, P27708Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase,CPSase, ATCase and DHOase)Catalytic activity: 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphateCatalytic activity: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartateCatalytic activity: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartateEnzyme regulation: Allosterically regulated and controlled by phosphorylation. 5-phosphoribose 1-diphosphate is anactivator while UMP is an inhibitor of the CPSase reaction Genatlas biochemistry entry for CAD:pyrimidine de novo biosynthesis,multifunctional polypeptide,200kDa (see CPS2,ASTC,DHO),putative up-regulated c-Myctarget gene,DNA metabolism
Enzyme Numbers (IUBMB): EC 2.1.3.22 EC 3.5.2.32 EC 6.3.52 EC 6.3.5.52
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004070 | aspartate carbamoyltransferase activity |
TAS | -- | | GO:0004088 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
TAS | -- | | GO:0004151 | dihydroorotase activity |
TAS | -- | | GO:0004672 | protein kinase activity |
ISS | -- | | GO:0005524 | ATP binding |
ISS | -- |
CAD for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for CAD:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAD (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CAD (NM_001608) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAD |
|
Pathways & Interactions
for CAD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyrimidine biosynthesis | | | 2 | Metabolism | | | 3 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 4 | MAP Kinase Signaling | | | 5 | Glucose / Energy Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CAD
4 
Cell Signaling Technology (CST) Pathways for CAD
1  GeneGo (Thomson Reuters) Pathway for CAD
4  BioSystems Pathways for CAD
4 
Reactome Pathways for CAD
3 
Kegg Pathways (Kegg details for CAD):
UniProtKB/Swiss-Prot: PYR1_HUMAN, P27708Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3
CAD for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/496 Interacting proteins for CAD (P277082, 3 ENSP000002647054) via UniProtKB, MINT, STRING, and/or I2D (see all 496)
About this table
Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006206 | pyrimidine nucleobase metabolic process |
TAS | -- | | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
ISS | -- | | GO:0006228 | UTP biosynthetic process |
IEA | -- | | GO:0006541 | glutamine metabolic process |
ISS | -- | | GO:0006543 | glutamine catabolic process |
IEA | -- |
CAD for ontologies About GeneDecksing
|
Drugs & Compounds
for CAD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CAD for compounds About GeneDecksing
 Browse Tocris compounds for CAD
10/15 HMDB Compounds for CAD (see all 15) About this table
3 DrugBank Compounds for CAD About this table
10/21 Novoseek chemical compound relationships for CAD gene (see all 21) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carbamoyl phosphate |
91.8 |
40 |
15326225 (3), 11872754 (1), 12438317 (1), 14991569 (1) (see all 19) |
| n-phosphonacetyl-l-aspartate |
90.5 |
12 |
9418900 (4), 8178710 (1), 11121244 (1), 12209881 (1) (see all 7) |
| carbamoyl-aspartate |
89.8 |
5 |
1967653 (2), 15610022 (1), 10517371 (1) |
| phosphonoacetamide |
89.6 |
4 |
2271529 (2), 2405902 (1) |
| dihydroorotate |
89.1 |
12 |
1979549 (2), 1967653 (1), 11080587 (1), 15610022 (1) (see all 8) |
| orotidine 5'-monophosphate |
85.7 |
5 |
11080587 (1), 19230569 (1), 7916185 (1) |
| pyrimidine |
84 |
30 |
12438317 (3), 8587126 (2), 14991569 (2), 9406429 (1) (see all 21) |
| orotic acid |
83.1 |
9 |
1974280 (2), 14746536 (1), 11080587 (1), 19230569 (1) (see all 6) |
| aspartate |
78.3 |
62 |
8587126 (2), 1444372 (2), 9344472 (2), 9050862 (2) (see all 37) |
| prpp |
69.4 |
2 |
10597272 (1) |
Search CenterWatch for drugs/clinical trials and news about CAD / PYR1
|
Transcripts
for CAD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAD gene: NM_004341.3 Unigene Cluster for CAD: Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Hs.377010 [show with all ESTs]Unigene Representative Sequence: BC06551011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264705(uc002rji.3 uc010eyw.3) ENST00000403525 ENST00000491891
ENST00000464159 ENST00000475695 ENST00000479002 ENST00000458503 ENST00000456311
ENST00000487239 ENST00000491461 ENST00000428460
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAD (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CAD (NM_001608) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAD |
Additional cDNA sequence: AB621827.1 AK226105.1 AL832309.1 BC014178.2 BC065510.1 D78586.1 10 DOTS entries: DT.40281285 DT.95336498 DT.91643392 DT.95143673 DT.100775623 DT.92019779 DT.86859832 DT.92440335 DT.102823198 DT.121001945 24/293 AceView cDNA sequences (see all 293): BQ057302 BP345421 BC014178 BU688097 AL039623 BM145957 BM668602 CD655203 BI438340 BQ065920 BM772042 BU845259 BM463252 BG034112 BG679911 BU931471 BQ423402 BM917236 BU838530 BU187133 BE779209 BG395722 AA293554 BQ063335
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CAD (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39a | · | 39b | ^ | 40a | · | 40b | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 41a | · | 41b | · | 41c | · | 41d | · | 41e | · | 41f | ^ | 42 | ^ | 43a | · | 43b | ^ | 44 | ^ | 45 | ^ | 46a | · | 46b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAD
|
Expression
for CAD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGTGGGGC
About this image
See CAD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAD
SOURCE GeneReport for Unigene cluster: Hs.377010
SABiosciences Expression via Pathway-Focused PCR Arrays including CAD:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAD |
Orthologs
for CAD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CAD gene from 10/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CAD1 |
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, more |
75.52(n)
81.47(a) |
|
428659 XM_003641068.1 XP_003641116.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CAD6 |
-- |
79(a) |
1 ↔ 1 |
AAWZ02036500(57-24918) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.247872 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.73(n) |
|
CA985873.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cad2 |
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, more |
80.26(n) |
|
266992 BI890762.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
r1 , 3 |
'de novo' pyrimidine base biosynthesis
aspartate more3
rudimentary1 |
52(a)3
63.56(n)1
65.66(a)1 |
|
326401 NM_078653.11 NP_523377.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
pyr-11 |
Protein PYR-1 |
56.94(n)
59.49(a) |
|
174385 NM_063437.3 NP_495838.2 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CPA2(YJR109C)4
URA21 |
Large subunit of carbamoyl phosphate synthetase, which more4
Ura2p1 |
52.57(n)1
53.43(a)1 |
|
10(632941-629585)4
8533111 NP_012405.21 8535734
NP_012643.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CARB6 |
carbamoyl phosphate synthetase B |
36(a) |
possible ortholog |
1(10468054-10472211) |
rice
(Oryza sativa) |
Liliopsida |
-- |
carbamoyl-phosphate synthase large chain, putative... |
36(a) |
possible ortholog |
1(21891743-21896902) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
carB6 |
carbamoyl-phosphate synthase large subunit |
40(a) |
possible ortholog |
Chromosome(30817-34038) |
ENSEMBL Gene Tree for CAD (if available)
TreeFam Gene Tree for CAD (if available) |
Paralogs
for CAD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAD gene
- CPS12
1 SIMAP similar gene for CAD using alignment to 9 protein entries: PYR1_HUMAN (see all proteins):CPS1
CAD for paralogs About GeneDecksing
|
Genomic Variants
for CAD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAD (27440258 - 27466660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAD: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAD |
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Disorders
/ Diseases
for CAD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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|
CAD for disorders About GeneDecksing
OMIM gene information: 114010
OMIM disorders: --
16  diseases for CAD: About MalaCardsburkitt's lymphoma fibrosarcoma hepatitis c breast cancer
t cell deficiency hepatitis pneumonia hypoxia
schizophrenia tuberculosis adenocarcinoma malaria
leukemia mycobacterium tuberculosis prostate cancer prostatitis
3 Novoseek disease relationships for CAD gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fibrosarcoma |
21.2 |
1 |
7746853 (1) |
| breast cancer |
0 |
5 |
12746293 (2), 16675542 (1) |
| tumors |
0 |
2 |
9050862 (1), 10657901 (1) |
Genetic Association Database (GAD): CAD
Human Genome Epidemiology (HuGE) Navigator: CAD (1314 documents)
Export disorders for CAD gene to outside databases
|
Publications
for CAD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAD gene, integrated from 9 sources (see all 135):
(articles sorted by number of sources associating them with CAD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase- dihydroorotase in de Novo pyrimidine synthesis. (PubMed id 8619816)1, 2, 3, 9 Iwahana H.... Itakura M. (1996)
- Organization and nucleotide sequence of the 3' end of the human CAD gene. (PubMed id 1979741)1, 2, 9 Davidson J.N....Chen K.C. (1990)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. (PubMed id 15621215)1, 4 Stessman J....Ebstein R.P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mapping of the gene encoding the multifunctional protein carrying out the first three steps of pyrimidine biosynthesis to human chromosome 2. (PubMed id 2565865)1, 3 Chen K.C....Davidson J.N. (1989)
- Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. (PubMed id 12746293)1, 9 Khan S....Safe S. (2003)
- Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. (PubMed id 11854437)1, 9 Huang M....Graves L.M. (2002)
- The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. (PubMed id 15326225)1, 9 Lindsey-Boltz L.A....Sancar A. (2004)
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External Searches for CAD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing CAD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAD | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Aspartate_carbamoyltransferase |
|
| | |
About This Section
| Patent Information for CAD gene:
Search GeneIP for patents involving CAD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | OriGene Antibodies for CAD | | OriGene shRNA RFP for CAD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAD | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAD | | OriGene 3'-UTR Clone for CAD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAD | | OriGene Custom Protein Services for CAD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAD |
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| | Antibodies & Assays for CAD |
| | | | Search Tocris compounds for CAD |
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 | | | CAD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAD |
|  |  |  |  | | | | ThermoFisher Antibodies for CAD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAD |
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