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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CACYBP Gene

protein-coding   GIFtS: 53
GCID: GC01P174968

calcyclin binding protein

 Explore 11 diseases affiliated with
CACYBP via our new
 Human Malady Compendium 
Biological research products
for CACYBP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Calcyclin Binding Protein1 2     RP1-102G20.62
SIP1 2 3 5     Calcyclin-Binding Protein2
S100A6BP1 2 3     Growth-Inhibiting Gene 5 Protein2
HCacyBP1     Siah-Interacting Protein (SIP)2
S100A6-Binding Protein2 3     CacyBP3
GIG52     Siah-Interacting Protein3

External Ids:    HGNC: 304231   Entrez Gene: 271012   Ensembl: ENSG000001161617   OMIM: 6061865   UniProtKB: Q9HB713   

Export aliases for CACYBP gene to outside databases

Previous GC identifers: GC00U920615 GC01P171701 GC01P173235 GC01P146194


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CACYBP:
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination
and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3
complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71
Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target
proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated
degradation of beta-catenin (CTNNB1)

Gene Wiki entry for CACYBP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CACYBP gene promoter:
         AML1a   SEF-1 (1)   FOXO3   FOXO3a   Evi-1   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CACYBP promoter sequence
   Search SABiosciences Chromatin IP Primers for CACYBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACYBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24-q25   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24-q25

CACYBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACYBP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P174968:  view genomic region     (about GC identifiers)

Start:
174,968,300 bp from pter      End:
174,981,163 bp from pter
Size:
12,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71 (See protein sequence)
Recommended Name: Calcyclin-binding protein  
Size: 228 amino acids; 26210 Da
Subunit: Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a
calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1,
CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after
a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear
fraction may be phosphorylated
Sequence caution: Sequence=AAG23817.1; Type=Frameshift; Positions=203;
3 PDB 3D structures from and Proteopedia for CACYBP:
1X5M (3D)        2A25 (3D)        2A26 (3D)    
Secondary accessions: B2ZWH2 O60666 Q5R371
Alternative splicing: 2 isoforms:  Q9HB71-1   Q9HB71-2   

Explore the universe of human proteins at neXtProt for CACYBP: NX_Q9HB71

Post-translational modifications:

  • Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HB71

  • CACYBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001007215.1  NP_055227.1  

    ENSEMBL proteins: 
     ENSP00000356654   ENSP00000403674   ENSP00000356652   ENSP00000384139   ENSP00000385771  

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    ProSpec Recombinant Protein for CACYBP
    Uscn Proteins for CACYBP

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus ----
    GO:0005641nuclear envelope lumen IEA--
    GO:0005737cytoplasm IDA--
    GO:0030877beta-catenin destruction complex IDA16085652


    CACYBP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CACYBP for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015120 Siah-Interact_N
     IPR007699 SGS
     IPR008978 HSP20-like_chaperone
     IPR017447 CS_domain
     IPR007052 CS-like_domain

    Graphical View of Domain Structure for InterPro Entry Q9HB71

    ProtoNet protein and cluster: Q9HB71

    UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71
    Similarity: Contains 1 CS domain
    Similarity: Contains 1 SGS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71
    Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target
    proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated
    degradation of beta-catenin (CTNNB1)

    miRNA
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    hsa-miR-607 hsa-miR-875-3p hsa-miR-499-3p hsa-miR-27a hsa-miR-605 hsa-miR-491-3p hsa-miR-1301 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCACYBP 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16085652
    GO:0042803protein homodimerization activity IPI16085652


    CACYBP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CACYBP:
     Increased G1 DNA content 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cacybp):
     cellular  hematopoietic system  immune system 

    CACYBP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch1.00
    2Protein Stability
    Protein Stability1.00
    3Wnt Signaling Pathway
    Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CACYBP
        Wnt / Hedgehog / Notch
    Protein Stability


    1         Kegg Pathway  (Kegg details for CACYBP):
        Wnt signaling pathway


    CACYBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CACYBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for CACYBP (Q9HB712, 3 ENSP000003566524) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIAH1Q8IUQ42, 3, ENSP000003491564MINT-18767 MINT-18768 I2D: score=4 STRING: ENSP00000349156
    SIAH2O432552, 3, ENSP000003224574MINT-19098 I2D: score=3 STRING: ENSP00000322457
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    STK3Q131883, ENSP000003905004I2D: score=3 STRING: ENSP00000390500
    S100A12P805113, ENSP000003577264I2D: score=2 STRING: ENSP00000357726
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007507heart development ----
    GO:0007568aging IEA--
    GO:0045740positive regulation of DNA replication IEA--
    GO:0055007cardiac muscle cell differentiation IEA--
    GO:0060416response to growth hormone stimulus IEA--


    CACYBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CACYBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CACYBP

    1 HMDB Compound for CACYBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for CACYBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 43.2 2 1999197 (1), 8365543 (1)

    Search CenterWatch for drugs/clinical trials and news about CACYBP / CYBP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CACYBP gene (2 alternative transcripts): 
    NM_001007214.1  NM_014412.2  

    Unigene Cluster for CACYBP:

    Calcyclin binding protein
    Hs.508524  [show with all ESTs]
    Unigene Representative Sequence: NM_014412
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367681(uc001gki.1) ENST00000426793 ENST00000461977 ENST00000367679(uc001gkj.1)
    ENST00000483307(uc010pmw.2) ENST00000473925 ENST00000406752 ENST00000405362
    ENST00000469173

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    hsa-miR-607 hsa-miR-875-3p hsa-miR-499-3p hsa-miR-27a hsa-miR-605 hsa-miR-491-3p hsa-miR-1301 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCACYBP 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF057356.1 AF275803.1 AF314752.1 AK093425.1 AK294042.1 AK313278.1 AL035305.1 AY423723.1 
    BC005975.1 BC022352.1 BC067823.1 BC078151.1 

    22 DOTS entries:

    DT.447539  DT.100654940  DT.91834648  DT.91848776  DT.100654927  DT.100654933  DT.92408092  DT.121344987 
    DT.92456332  DT.100654932  DT.100654936  DT.121344788  DT.92456331  DT.100804781  DT.120958671  DT.75176456 
    DT.92456342  DT.100059514  DT.100654929  DT.100666074  DT.121344702  DT.92452077 

    24/459 AceView cDNA sequences (see all 459):

    CB140991 BM554944 AI832841 AI918769 AL557182 CB159933 BG565793 BQ424722 
    Z42909 BM846241 AV708614 AV713926 BX646555 BF475708 CB112455 BU624151 
    CR601618 BC078151 BM968214 CR626371 BX361914 AA664748 AA810152 T33750 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CACYBP (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -     -     -                                                         
    SP2:                                -                                                         
    SP3:                                -                 -                                       
    SP4:                                                                                          
    SP5:              -     -           -                                                         


    ECgene alternative splicing isoforms for CACYBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CACYBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGTGAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CACYBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CACYBP

    SOURCE GeneReport for Unigene cluster: Hs.508524
        SABiosciences Custom PCR Arrays for CACYBP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACYBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CACYBP gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacybp1 , 5 calcyclin binding protein1, 5 89.58(n)1
    93.75(a)1
      1 (69.61 cM)5
    123011  NM_009786.21  NP_033916.11 
     1602023675 
    chicken
    (Gallus gallus)
    Aves CACYBP1 calcyclin binding protein 72.14(n)
    72.77(a)
      424437  XM_422279.3  XP_422279.1 
    lizard
    (Anolis carolinensis)
    Reptilia CACYBP6
    --
    68(a)
    1 ↔ 1
    4(71725884-71732467)
    African clawed frog
    (Xenopus laevis)
    Amphibia sip-prov2 Siah-interacting protein 75.95(n)    BC046706.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cacybp1 calcyclin binding protein 61.99(n)
    62.62(a)
      405823  NM_212887.1  NP_998052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32261 CG3226 49.54(n)
    42.59(a)
      31597  NM_132104.3  NP_572332.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G300701 calcyclin binding protein 46.98(n)
    34.29(a)
      839886  NM_001198184.1  NP_001185113.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07575001 hypothetical protein 47.14(n)
    33.81(a)
      4325302  NM_001050829.1  NP_001044294.1 


    ENSEMBL Gene Tree for CACYBP (if available)
    TreeFam Gene Tree for CACYBP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CACYBP gene

    CACYBP for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CACYBP
    PGOHUM00000238569 PGOHUM00000240449 PGOHUM00000243431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 NCBI SNPs in CACYBP are shown (see all 249    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs31784841,2
    F,--146193178(-) ATGGGT/AAGAAG 1 -- us2k12Minor allele frequency- A:0.10MN NA 304
    rs802075281,2
    F,--146193437(+) ATATTC/TGTCTC 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs743283831,2
    --146193438(+) TATTCG/TTCTCT 2 -- us2k10--------
    rs37525711,2
    C,F,H,--146194552(-) TTCAGA/GTTATT 2 -- us2k16Minor allele frequency- G:0.01EA NS 2076
    rs618281551,2
    C,--146194781(+) GAAACC/TGTGGC 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1113352251,2
    C,--146194784(+) ACTGTG/AGCCAT 2 -- us2k12Minor allele frequency- A:0.06CSA WA 120
    rs786468241,2
    --146194791(+) CCATAG/AGCGGG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs32135791,2
    F--146194875(-) CTGGCC/TGCCGT 2 -- us2k11Minor allele frequency- T:0.03EA 1500
    rs1163514651,2
    C,F,--146195008(+) TTGAAA/GGTAAC 2 -- ut51 us2k11Minor allele frequency- G:0.07WA 118
    rs115489131,2
    --146195144(+) TTCCGA/TCTTGG 2 -- ut51 us2k10--------

    HapMap Linkage Disequilibrium report for CACYBP (174968300 - 174981163 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CACYBP: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CACYBP for disorders           About GeneDecksing

    OMIM gene information: 606186    OMIM disorders: --

    11 diseases for CACYBP:    About MalaCards
    differentiating neuroblastoma    renal cell carcinoma    gastric cancer    neuroblastoma
    pancreatic cancer    breast cancer    pancreatitis    hypoxia
    carcinoma    malaria    neuronitis

    1 Novoseek disease relationship for CACYBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 56.3 19 15449204 (6), 12485490 (4), 15191727 (1), 16704310 (1) (see all 5)


    Export disorders for CACYBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CACYBP gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with CACYBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839)1, 2, 3 Matsuzawa S. and Reed J.C. (2001)
    2. Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH- SY5Y cells. (PubMed id 12895292)1, 2, 9 Wu J.... Qiang B.Q. (2003)
    3. Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). (PubMed id 12421809)1, 3, 9 Matsuzawa S....Ely K.R. (2003)
    4. Cloning and expression of human calcyclin binding protein (hCacyBP) gene. (PubMed id 12006993)1, 2, 9 Liu W.X.... Qiang B.Q. (2002)
    5. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PubMed id 16085652)1, 2, 9 Santelli E....Matsuzawa S. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. (PubMed id 18443365)1, 9 Zhai H....Fan D. (2008)
    9. Expression and clinical significance of CacyBP/SIP in pancreatic cancer. (PubMed id 18765951)1, 9 Chen X....Fan D. (2008)
    10. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 9 Filipek A....Kuznicki J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27101 HGNC: 30423 AceView: SIP Ensembl:ENSG00000116161 euGenes: HUgn27101
    ECgene: CACYBP Kegg: 27101 H-InvDB: CACYBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CACYBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CACYBP gene:
    Search GeneIP for patents involving CACYBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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