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CACYBP Gene

protein-coding   GIFtS: 54
GCID: GC01P174968

Calcyclin Binding Protein

  See CACYBP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcyclin Binding Protein1 2     Calcyclin-Binding Protein2
SIP2 3 5     Growth-Inhibiting Gene 5 Protein2
S100A6BP2 3     Siah-Interacting Protein (SIP)2
hCacyBP2 3     CacyBP3
S100A6-Binding Protein2 3     Siah-Interacting Protein3
GIG52     

External Ids:    HGNC: 304231   Entrez Gene: 271012   Ensembl: ENSG000001161617   OMIM: 6061865   UniProtKB: Q9HB713   

Export aliases for CACYBP gene to outside databases

Previous GC identifers: GC00U920615 GC01P171701 GC01P173235 GC01P146194


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CACYBP Gene:
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent
ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular
bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CACYBP Gene:
CACYBP (calcyclin binding protein) is a protein-coding gene. Diseases associated with CACYBP include neuroblastoma. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71
Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target
proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated
degradation of beta-catenin (CTNNB1)

Gene Wiki entry for CACYBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CACYBP gene promoter:
         AML1a   SEF-1 (1)   FOXO3   FOXO3a   Evi-1   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CACYBP promoter sequence
   Search Chromatin IP Primers for CACYBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACYBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24-q25   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24-q25

CACYBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACYBP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P174968:  view genomic region     (about GC identifiers)

Start:
174,968,300 bp from pter      End:
174,981,163 bp from pter
Size:
12,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71 (See protein sequence)
Recommended Name: Calcyclin-binding protein  
Size: 228 amino acids; 26210 Da
Subunit: Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a
calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1,
CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1
Sequence caution: Sequence=AAG23817.1; Type=Frameshift; Positions=203; Sequence=BAG52713.1; Type=Frameshift;
Positions=3;
3 PDB 3D structures from and Proteopedia for CACYBP:
1X5M (3D)        2A25 (3D)        2A26 (3D)    
Secondary accessions: B2ZWH2 B3KSF1 O60666 Q5R370 Q5R371
Alternative splicing: 3 isoforms:  Q9HB71-1   Q9HB71-2   Q9HB71-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CACYBP: NX_Q9HB71

Explore proteomics data for CACYBP at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations1
  • Ubiquitination2 at Lys14, Lys51, Lys85, Lys118, Lys123, Lys146, Lys178, Lys196, Lys197, Lys207,
                                 Lys212, Lys223
  • Modification sites at PhosphoSitePlus

  • See CACYBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001007215.1  NP_055227.1  

    ENSEMBL proteins: 
     ENSP00000356654   ENSP00000403674   ENSP00000356652   ENSP00000384139   ENSP00000385771  

    CACYBP Human Recombinant Protein Products:

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    Novus Biologicals CACYBP Proteins
    Novus Biologicals CACYBP Lysates
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    ProSpec Recombinant Protein for CACYBP
    Cloud-Clone Corp. Proteins for CACYBP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015120 Siah-Interact_N
     IPR007699 SGS
     IPR008978 HSP20-like_chaperone
     IPR007052 CS_dom

    Graphical View of Domain Structure for InterPro Entry Q9HB71

    ProtoNet protein and cluster: Q9HB71

    UniProtKB/Swiss-Prot: CYBP_HUMAN, Q9HB71
    Similarity: Contains 1 CS domain
    Similarity: Contains 1 SGS domain


    Find genes that share domains with CACYBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYBP_HUMAN, Q9HB71
    Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target
    proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated
    degradation of beta-catenin (CTNNB1)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16085652
    GO:0042803protein homodimerization activity IPI16085652
         
    Find genes that share ontologies with CACYBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CACYBP:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cacybp):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CACYBP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CACYBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CACYBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CACYBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CACYBP

    miRNA
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    hsa-miR-607 hsa-miR-875-3p hsa-miR-499-3p hsa-miR-27a hsa-miR-605 hsa-miR-491-3p hsa-miR-1301 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCACYBP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CACYBP
    Predesigned siRNA for gene silencing in human, mouse, rat CACYBP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CACYBP (NM_001007214)
    Sino Biological Human cDNA Clone for CACYBP
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACYBP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACYBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYBP_HUMAN, Q9HB71: Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells,
    after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The
    nuclear fraction may be phosphorylated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005641nuclear envelope lumen IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030877beta-catenin destruction complex IDA16085652

    Find genes that share ontologies with CACYBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CACYBP About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Protein Stability
    Protein Stability
    4Gastric cancer network 2
    Gastric cancer network 2


    Find genes that share SuperPaths with CACYBP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CACYBP
        Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for CACYBP
        Gastric cancer network 2



    1 Kegg Pathway  (Kegg details for CACYBP):
        Wnt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CACYBP
    Interactions:

        GeneGlobe Interaction Network for CACYBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CACYBP (Q9HB712, 3 ENSP000003566524) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIAH1Q8IUQ42, 3, ENSP000003491564MINT-18767 MINT-18768 I2D: score=4 STRING: ENSP00000349156
    SIAH2O432552, 3, ENSP000003224574MINT-19098 I2D: score=3 STRING: ENSP00000322457
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    STK3Q131883, ENSP000003905004I2D: score=3 STRING: ENSP00000390500
    S100A12P805113, ENSP000003577264I2D: score=2 STRING: ENSP00000357726
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007507heart development ----
    GO:0007568aging IEA--
    GO:0045740positive regulation of DNA replication IEA--
    GO:0055007cardiac muscle cell differentiation IEA--
    GO:0060416response to growth hormone IEA--

    Find genes that share ontologies with CACYBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CACYBP (CYBP)

    1 HMDB Compound for CACYBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CACYBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 43.2 2 1999197 (1), 8365543 (1)



    Find genes that share compounds with CACYBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CACYBP gene (2 alternative transcripts): 
    NM_001007214.1  NM_014412.2  

    Unigene Cluster for CACYBP:

    Calcyclin binding protein
    Hs.508524  [show with all ESTs]
    Unigene Representative Sequence: NM_014412
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367681(uc001gki.1) ENST00000426793 ENST00000461977 ENST00000367679(uc001gkj.1)
    ENST00000483307(uc010pmw.2) ENST00000473925 ENST00000406752 ENST00000405362
    ENST00000469173
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CACYBP (see all 12):
    hsa-miR-607 hsa-miR-875-3p hsa-miR-499-3p hsa-miR-27a hsa-miR-605 hsa-miR-491-3p hsa-miR-1301 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCACYBP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CACYBP (NM_001007214)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CACYBP
      QuantiFast Probe-based Assays in human, mouse, rat CACYBP

    Additional mRNA sequence: 

    AF057356.1 AF275803.1 AF314752.1 AK093425.1 AK294042.1 AK313278.1 AL035305.1 AY423723.1 
    BC005975.1 BC022352.1 BC067823.1 BC078151.1 

    22 DOTS entries:

    DT.447539  DT.100654940  DT.91834648  DT.91848776  DT.100654927  DT.100654933  DT.92408092  DT.121344987 
    DT.92456332  DT.100654932  DT.100654936  DT.121344788  DT.92456331  DT.100804781  DT.120958671  DT.75176456 
    DT.92456342  DT.100059514  DT.100654929  DT.100666074  DT.121344702  DT.92452077 

    Selected AceView cDNA sequences (see all 459):

    CB159933 AA622034 BC078151 CR591438 CB160816 CR591846 CF145259 BQ439950 
    BM976036 AA810152 CR601618 CD722567 BU557001 BG944204 CB107458 AF314752 
    CB112455 BM554944 AI480175 AV713926 CB156627 AA253132 CR607143 AI360210 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CACYBP (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -     -     -                                                         
    SP2:                                -                                                         
    SP3:                                -                 -                                       
    SP4:                                                                                          
    SP5:              -     -           -                                                         


    ECgene alternative splicing isoforms for CACYBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CACYBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTGAACA
    CACYBP Expression
    About this image


    CACYBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CACYBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CACYBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508524
        Custom PCR Arrays for CACYBP
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CACYBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACYBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CACYBP gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacybp1 , 5 calcyclin binding protein1, 5 89.57(n)1
    93.83(a)1
      1 (69.61 cM)5
    123011  NM_009786.21  NP_033916.11 
     1602023675 
    chicken
    (Gallus gallus)
    Aves CACYBP1 calcyclin binding protein 72.14(n)
    72.77(a)
      424437  XM_422279.4  XP_422279.1 
    lizard
    (Anolis carolinensis)
    Reptilia CACYBP6
    calcyclin binding protein
    67(a)
    1 ↔ 1
    4(71725884-71732467)
    African clawed frog
    (Xenopus laevis)
    Amphibia sip-prov2 Siah-interacting protein 75.95(n)    BC046706.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cacybp1 calcyclin binding protein 62.31(n)
    62.62(a)
      405823  NM_212887.1  NP_998052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32261 CG3226 49.38(n)
    42.59(a)
      31597  NM_132104.3  NP_572332.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G300701 AT1G30070 47.18(n)
    34.3(a)
      839886  NM_001198184.1  NP_001185113.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07575001 Os01g0757500 47.3(n)
    34.29(a)
      4325302  NM_001050829.1  NP_001044294.1 


    ENSEMBL Gene Tree for CACYBP (if available)
    TreeFam Gene Tree for CACYBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CACYBP gene

    Find genes that share paralogs with CACYBP           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CACYBP
    PGOHUM00000238569 PGOHUM00000240449 PGOHUM00000243431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CACYBP (see all 312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128361291,2
    C--174970985(+) GGATTC/TTCCTG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs674461621,2
    C--174978780(-) CATGA-/TTTTTT 2 -- int12Minor allele frequency- T:0.25NA 4
    rs3685190761,2
    C--174979812(+) CATAT-/TTTTGTA 4 -- ut310--------
    rs1382780521,2
    C--181520179(+) AGATAC/TGTAAA 1 -- us2k10--------
    rs118111901,2
    C,H--181520394(+) gtgCGT/CAGGGT 1 -- us2k14Minor allele frequency- C:0.14NA WA EA 360
    rs31784841,2
    F--181520420(-) ATGGGT/AAGAAG 1 -- us2k12Minor allele frequency- A:0.10MN NA 304
    rs1870471711,2
    --181520431(+) TTTAGG/TCTCAC 1 -- us2k10--------
    rs1911569941,2
    --181520610(+) TGTGAC/TGGGGC 2 -- us2k10--------
    rs802075281,2
    C,F--181520679(+) ATATTC/TGTCTC 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs743283831,2
    C--181520680(+) TATTCG/TTCTCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CACYBP (174968300 - 174981163 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CACYBP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CACYBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CACYBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606186    OMIM disorders: --

    1 disease for CACYBP:    
    About MalaCards
    neuroblastoma


    Find genes that share disorders with CACYBP           About GenesLikeMe

    1 Novoseek inferred disease relationship for CACYBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 56.3 19 15449204 (6), 12485490 (4), 15191727 (1), 16704310 (1) (see all 5)


    Export disorders for CACYBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CACYBP gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with CACYBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839)1, 2, 3 Matsuzawa S. and Reed J.C. (Mol. Cell 2001)
    2. Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH- SY5Y cells. (PubMed id 12895292)1, 2, 9 Wu J.... Qiang B.Q. (J. Biochem. Mol. Biol. 2003)
    3. Structural analysis of Siah1 and its interactions with Siah- interacting protein (SIP). (PubMed id 12421809)1, 3, 9 Matsuzawa S.... Ely K.R. (J. Biol. Chem. 2003)
    4. Cloning and expression of human calcyclin binding protein (hCacyBP) gene. (PubMed id 12006993)1, 2, 9 Liu W.X.... Qiang B.Q. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002)
    5. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PubMed id 16085652)1, 2, 9 Santelli E.... Matsuzawa S. (J. Biol. Chem. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. (PubMed id 18443365)1, 9 Zhai H....Fan D. (J. Histochem. Cytochem. 2008)
    9. Expression and clinical significance of CacyBP/SIP in pancreatic cancer. (PubMed id 18765951)1, 9 Chen X....Fan D. (Pancreatology 2008)
    10. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. (PubMed id 12042313)1, 9 Filipek A.... Kuznicki J. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27101 HGNC: 30423 AceView: SIP Ensembl:ENSG00000116161 euGenes: HUgn27101
    ECgene: CACYBP Kegg: 27101 H-InvDB: CACYBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CACYBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CACYBP gene:
    Search GeneIP for patents involving CACYBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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