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Aliases for CACYBP Gene

Aliases for CACYBP Gene

  • Calcyclin Binding Protein 2 3 5
  • S100A6-Binding Protein 3 4
  • S100A6BP 3 4
  • HCacyBP 3 4
  • SIP 3 4
  • Growth-Inhibiting Gene 5 Protein 3
  • Siah-Interacting Protein (SIP) 3
  • Calcyclin-Binding Protein 3
  • Siah-Interacting Protein 4
  • PNAS-107 3
  • CacyBP 4
  • GIG5 3

External Ids for CACYBP Gene

Previous GeneCards Identifiers for CACYBP Gene

  • GC00U920615
  • GC01P171701
  • GC01P173235
  • GC01P146194

Summaries for CACYBP Gene

Entrez Gene Summary for CACYBP Gene

  • The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CACYBP Gene

CACYBP (Calcyclin Binding Protein) is a Protein Coding gene. Diseases associated with CACYBP include Neuroblastoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Wnt / Hedgehog / Notch. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for CACYBP Gene

  • May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Gene Wiki entry for CACYBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACYBP Gene

Genomics for CACYBP Gene

Regulatory Elements for CACYBP Gene

Enhancers for CACYBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G174963 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -31.4 -31415 9.2 HDGF PKNOX1 ARNT WRNIP1 FEZF1 YY1 ZNF766 FOS JUNB TBX21 RABGAP1L RNU6-307P CACYBP TNN KIAA0040 LOC101928696
GH01G174938 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -60.3 -60315 1.6 PKNOX1 JUNB FEZF1 TBX21 PRDM6 IKZF1 TCF7 ETV6 CACYBP RC3H1 RPS26P12 LOC101928696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CACYBP on UCSC Golden Path with GeneCards custom track

Promoters for CACYBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016086 837 2801 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 TBX21

Genomic Location for CACYBP Gene

Chromosome:
1
Start:
174,999,163 bp from pter
End:
175,012,027 bp from pter
Size:
12,865 bases
Orientation:
Plus strand

Genomic View for CACYBP Gene

Genes around CACYBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACYBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACYBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACYBP Gene

Proteins for CACYBP Gene

  • Protein details for CACYBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB71-CYBP_HUMAN
    Recommended name:
    Calcyclin-binding protein
    Protein Accession:
    Q9HB71
    Secondary Accessions:
    • B2ZWH2
    • B3KSF1
    • O60666
    • Q5R370
    • Q5R371

    Protein attributes for CACYBP Gene

    Size:
    228 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.
    SequenceCaution:
    • Sequence=AAG23817.1; Type=Frameshift; Positions=203; Evidence={ECO:0000305}; Sequence=BAG52713.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CACYBP Gene

    Alternative splice isoforms for CACYBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACYBP Gene

Post-translational modifications for CACYBP Gene

  • Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
  • Ubiquitination at posLast=5151, posLast=118118, posLast=123123, Lys146, posLast=196196, Lys207, posLast=212212, and posLast=223223
  • Modification sites at PhosphoSitePlus

Other Protein References for CACYBP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CACYBP (CACYBP)
  • Cloud-Clone Corp. Antibodies for CACYBP

No data available for DME Specific Peptides for CACYBP Gene

Domains & Families for CACYBP Gene

Protein Domains for CACYBP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CACYBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CACYBP Gene

Function for CACYBP Gene

Molecular function for CACYBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Gene Ontology (GO) - Molecular Function for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085652
GO:0019904 protein domain specific binding IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0042803 protein homodimerization activity IPI 16085652
genes like me logo Genes that share ontologies with CACYBP: view
genes like me logo Genes that share phenotypes with CACYBP: view

Animal Models for CACYBP Gene

MGI Knock Outs for CACYBP:

Animal Model Products

  • Taconic Biosciences Mouse Models for CACYBP

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CACYBP Gene

Localization for CACYBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACYBP Gene

Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CACYBP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005641 nuclear envelope lumen IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CACYBP: view

Pathways & Interactions for CACYBP Gene

genes like me logo Genes that share pathways with CACYBP: view

Pathways by source for CACYBP Gene

1 Cell Signaling Technology pathway for CACYBP Gene
1 BioSystems pathway for CACYBP Gene
1 KEGG pathway for CACYBP Gene

Gene Ontology (GO) - Biological Process for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
GO:0007568 aging IEA --
GO:0045740 positive regulation of DNA replication IEA --
GO:0055007 cardiac muscle cell differentiation IEA --
GO:0060416 response to growth hormone IEA --
genes like me logo Genes that share ontologies with CACYBP: view

No data available for SIGNOR curated interactions for CACYBP Gene

Drugs & Compounds for CACYBP Gene

(1) Drugs for CACYBP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CACYBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CACYBP: view

Transcripts for CACYBP Gene

Unigene Clusters for CACYBP Gene

Calcyclin binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACYBP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -
SP6: - - - -

Relevant External Links for CACYBP Gene

GeneLoc Exon Structure for
CACYBP
ECgene alternative splicing isoforms for
CACYBP

Expression for CACYBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CACYBP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CACYBP Gene



Protein tissue co-expression partners for CACYBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CACYBP Gene:

CACYBP

SOURCE GeneReport for Unigene cluster for CACYBP Gene:

Hs.508524

Evidence on tissue expression from TISSUES for CACYBP Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CACYBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CACYBP Gene

Orthologs for CACYBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CACYBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACYBP 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia CACYBP 34 35
  • 93.54 (n)
cow
(Bos Taurus)
Mammalia CACYBP 34 35
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Cacybp 34 16 35
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Cacybp 34
  • 88.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CACYBP 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACYBP 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACYBP 34 35
  • 72.14 (n)
lizard
(Anolis carolinensis)
Reptilia CACYBP 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacybp 34
  • 70.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia sip-prov 34
zebrafish
(Danio rerio)
Actinopterygii cacybp 34 35
  • 62.31 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4424 34
fruit fly
(Drosophila melanogaster)
Insecta CG3226 34 35
  • 49.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002107 34
  • 49.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30070 34
  • 47.18 (n)
rice
(Oryza sativa)
Liliopsida Os01g0757500 34
  • 47.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2662 35
  • 40 (a)
OneToOne
Species where no ortholog for CACYBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACYBP Gene

ENSEMBL:
Gene Tree for CACYBP (if available)
TreeFam:
Gene Tree for CACYBP (if available)

Paralogs for CACYBP Gene

Pseudogenes.org Pseudogenes for CACYBP Gene

genes like me logo Genes that share paralogs with CACYBP: view

No data available for Paralogs for CACYBP Gene

Variants for CACYBP Gene

Sequence variations from dbSNP and Humsavar for CACYBP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000477940 -- 175,003,222(+) CAAGC(A/G)ATTCT intron-variant
rs1000633641 -- 175,007,863(+) AAATC(-/AGAT)AGTCC intron-variant
rs1000839845 -- 175,000,318(+) GTCAG(C/T)GCGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001814361 -- 175,008,384(+) TGTCT(A/T)GATAG intron-variant
rs1002278217 -- 175,012,159(+) ATAAC(C/T)ATCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CACYBP Gene

Variant ID Type Subtype PubMed ID
nsv1001000 CNV gain 25217958
nsv946511 CNV duplication 23825009

Variation tolerance for CACYBP Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACYBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CACYBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACYBP Gene

Disorders for CACYBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CACYBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CACYBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACYBP
genes like me logo Genes that share disorders with CACYBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACYBP Gene

Publications for CACYBP Gene

  1. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PMID: 16085652) Santelli E. … Matsuzawa S. (J. Biol. Chem. 2005) 3 4 22 64
  2. Structural analysis of Siah1 and its interactions with Siah- interacting protein (SIP). (PMID: 12421809) Matsuzawa S. … Ely K.R. (J. Biol. Chem. 2003) 2 3 22 64
  3. Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH- SY5Y cells. (PMID: 12895292) Wu J. … Qiang B.Q. (J. Biochem. Mol. Biol. 2003) 3 4 22 64
  4. Cloning and expression of human calcyclin binding protein (hCacyBP) gene. (PMID: 12006993) Liu W.X. … Qiang B.Q. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 4 22 64
  5. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PMID: 11389839) Matsuzawa S. … Reed J.C. (Mol. Cell 2001) 2 3 4 64

Products for CACYBP Gene

Sources for CACYBP Gene

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