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Aliases for CACYBP Gene

Aliases for CACYBP Gene

  • Calcyclin Binding Protein 2 3 5
  • S100A6-Binding Protein 3 4
  • S100A6BP 3 4
  • HCacyBP 3 4
  • SIP 3 4
  • Growth-Inhibiting Gene 5 Protein 3
  • Siah-Interacting Protein (SIP) 3
  • Siah-Interacting Protein 4
  • PNAS-107 3
  • CacyBP 4
  • GIG5 3

External Ids for CACYBP Gene

Previous GeneCards Identifiers for CACYBP Gene

  • GC00U920615
  • GC01P171701
  • GC01P173235
  • GC01P146194

Summaries for CACYBP Gene

Entrez Gene Summary for CACYBP Gene

  • The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CACYBP Gene

CACYBP (Calcyclin Binding Protein) is a Protein Coding gene. Diseases associated with CACYBP include Gastric Cancer and Neuroblastoma. Among its related pathways are Wnt signaling pathway (KEGG) and Gastric cancer network 2. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for CACYBP Gene

  • May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Gene Wiki entry for CACYBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACYBP Gene

Genomics for CACYBP Gene

Regulatory Elements for CACYBP Gene

Promoters for CACYBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CACYBP on UCSC Golden Path with GeneCards custom track

Genomic Location for CACYBP Gene

174,999,163 bp from pter
175,012,027 bp from pter
12,865 bases
Plus strand

Genomic View for CACYBP Gene

Genes around CACYBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACYBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACYBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACYBP Gene

Proteins for CACYBP Gene

  • Protein details for CACYBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcyclin-binding protein
    Protein Accession:
    Secondary Accessions:
    • B2ZWH2
    • B3KSF1
    • O60666
    • Q5R370
    • Q5R371

    Protein attributes for CACYBP Gene

    228 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.
    • Sequence=AAG23817.1; Type=Frameshift; Positions=203; Evidence={ECO:0000305}; Sequence=BAG52713.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CACYBP Gene

    Alternative splice isoforms for CACYBP Gene


neXtProt entry for CACYBP Gene

Proteomics data for CACYBP Gene at MOPED

Post-translational modifications for CACYBP Gene

  • Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
  • Ubiquitination at Lys 51, Lys 118, Lys 123, Lys 146, Lys 196, Lys 207, Lys 212, and Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for CACYBP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CACYBP (CACYBP)

No data available for DME Specific Peptides for CACYBP Gene

Domains & Families for CACYBP Gene

Protein Domains for CACYBP Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CS domain.
  • Contains 1 CS domain.
  • Contains 1 SGS domain.
genes like me logo Genes that share domains with CACYBP: view

No data available for Gene Families for CACYBP Gene

Function for CACYBP Gene

Molecular function for CACYBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
genes like me logo Genes that share phenotypes with CACYBP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CACYBP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CACYBP Gene

Localization for CACYBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACYBP Gene

Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Subcellular locations from

Jensen Localization Image for CACYBP Gene COMPARTMENTS Subcellular localization image for CACYBP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CACYBP: view

Pathways & Interactions for CACYBP Gene

genes like me logo Genes that share pathways with CACYBP: view

Pathways by source for CACYBP Gene

1 Cell Signaling Technology pathway for CACYBP Gene
1 BioSystems pathway for CACYBP Gene
1 KEGG pathway for CACYBP Gene

Gene Ontology (GO) - Biological Process for CACYBP Gene


No data available for SIGNOR curated interactions for CACYBP Gene

Drugs & Compounds for CACYBP Gene

(1) Drugs for CACYBP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CACYBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CACYBP: view

Transcripts for CACYBP Gene

Unigene Clusters for CACYBP Gene

Calcyclin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACYBP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP5: - - -
SP6: - - - -

Relevant External Links for CACYBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CACYBP Gene

mRNA expression in normal human tissues for CACYBP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACYBP Gene

SOURCE GeneReport for Unigene cluster for CACYBP Gene Hs.508524

genes like me logo Genes that share expression patterns with CACYBP: view

Protein tissue co-expression partners for CACYBP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CACYBP Gene

Orthologs for CACYBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CACYBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CACYBP 35
  • 91.92 (n)
  • 95.15 (a)
  • 94 (a)
(Canis familiaris)
Mammalia CACYBP 35
  • 93.54 (n)
  • 97.8 (a)
  • 59 (a)
(Mus musculus)
Mammalia Cacybp 35
  • 89.57 (n)
  • 93.83 (a)
Cacybp 16
Cacybp 36
  • 92 (a)
(Pan troglodytes)
Mammalia CACYBP 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cacybp 35
  • 88.69 (n)
  • 92.51 (a)
(Monodelphis domestica)
Mammalia CACYBP 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia CACYBP 36
  • 82 (a)
(Gallus gallus)
Aves CACYBP 35
  • 72.14 (n)
  • 72.77 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia CACYBP 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cacybp 35
  • 70.29 (n)
  • 72.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia sip-prov 35
(Danio rerio)
Actinopterygii cacybp 35
  • 62.31 (n)
  • 62.62 (a)
cacybp 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4424 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002107 35
  • 49.22 (n)
  • 44.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3226 35
  • 49.38 (n)
  • 42.59 (a)
CG3226 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30070 35
  • 47.18 (n)
  • 34.3 (a)
(Oryza sativa)
Liliopsida Os01g0757500 35
  • 47.3 (n)
  • 34.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2662 36
  • 40 (a)
Species with no ortholog for CACYBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACYBP Gene

Gene Tree for CACYBP (if available)
Gene Tree for CACYBP (if available)

Paralogs for CACYBP Gene Pseudogenes for CACYBP Gene

genes like me logo Genes that share paralogs with CACYBP: view

No data available for Paralogs for CACYBP Gene

Variants for CACYBP Gene

Sequence variations from dbSNP and Humsavar for CACYBP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12271 -- 175,010,622(-) CAAAT(A/T)TATTT utr-variant-3-prime
rs984380 -- 175,011,039(-) gcagc(A/C)ttaaa utr-variant-3-prime
rs984381 -- 175,010,962(-) CTTCA(A/G)TTGCT utr-variant-3-prime
rs1034462 -- 175,011,187(-) TTCCC(A/G)TATTA utr-variant-3-prime
rs1984418 -- 175,008,967(-) AAGCC(C/T)CTCTC intron-variant

Variation tolerance for CACYBP Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CACYBP Gene

Disorders for CACYBP Gene

MalaCards: The human disease database

(2) MalaCards diseases for CACYBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CACYBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CACYBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACYBP Gene

Publications for CACYBP Gene

  1. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PMID: 11389839) Matsuzawa S. … Reed J.C. (Mol. Cell 2001) 2 3 4 67
  2. Structural analysis of Siah1 and its interactions with Siah- interacting protein (SIP). (PMID: 12421809) Matsuzawa S. … Ely K.R. (J. Biol. Chem. 2003) 2 3 23
  3. Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. (PMID: 18443365) Zhai H. … Fan D. (J. Histochem. Cytochem. 2008) 3 23
  4. Expression and clinical significance of CacyBP/SIP in pancreatic cancer. (PMID: 18765951) Chen X. … Fan D. (Pancreatology 2008) 3 23
  5. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PMID: 16085652) Santelli E. … Matsuzawa S. (J. Biol. Chem. 2005) 3 23

Products for CACYBP Gene

Sources for CACYBP Gene