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Aliases for CACUL1 Gene

Aliases for CACUL1 Gene

  • CDK2-Associated, Cullin Domain 1 2 3
  • Cdk-Associated Cullin1 2 3 4
  • C10orf46 3 4
  • CAC1 3 4
  • Chromosome 10 Open Reading Frame 46 2
  • Cullin 3

External Ids for CACUL1 Gene

Previous HGNC Symbols for CACUL1 Gene

  • C10orf46

Previous GeneCards Identifiers for CACUL1 Gene

  • GC10M120433

Summaries for CACUL1 Gene

GeneCards Summary for CACUL1 Gene

CACUL1 (CDK2-Associated, Cullin Domain 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for CACUL1 Gene

  • Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACUL1 Gene

Genomics for CACUL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACUL1 Gene

Chromosome:
10
Start:
118,672,993 bp from pter
End:
118,755,249 bp from pter
Size:
82,257 bases
Orientation:
Minus strand

Genomic View for CACUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CACUL1 Gene

No data available for Regulatory Elements for CACUL1 Gene

Proteins for CACUL1 Gene

  • Protein details for CACUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y37-CACL1_HUMAN
    Recommended name:
    CDK2-associated and cullin domain-containing protein 1
    Protein Accession:
    Q86Y37
    Secondary Accessions:
    • Q5XPL7
    • Q8IY11
    • Q8N7S4

    Protein attributes for CACUL1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41064 Da
    Quaternary structure:
    • Interacts with CDK2.
    SequenceCaution:
    • Sequence=AAU89709.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305};

    Alternative splice isoforms for CACUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACUL1 Gene

Proteomics data for CACUL1 Gene at MOPED

Post-translational modifications for CACUL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACUL1 Gene

Domains & Families for CACUL1 Gene

Protein Domains for CACUL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CACUL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y37

UniProtKB/Swiss-Prot:

CACL1_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CACUL1: view

No data available for Gene Families for CACUL1 Gene

Function for CACUL1 Gene

Molecular function for CACUL1 Gene

UniProtKB/Swiss-Prot Function:
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

Gene Ontology (GO) - Molecular Function for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23178685
GO:0019901 protein kinase binding IPI 19829063
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CACUL1: view

Phenotypes for CACUL1 Gene

genes like me logo Genes that share phenotypes with CACUL1: view

Animal Model Products

miRNA for CACUL1 Gene

miRTarBase miRNAs that target CACUL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACUL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CACUL1 Gene

Localization for CACUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACUL1 Gene COMPARTMENTS Subcellular localization image for CACUL1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IBA --
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CACUL1 Gene

Pathways & Interactions for CACUL1 Gene

SuperPathways for CACUL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 19829063
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0008284 positive regulation of cell proliferation IMP 19829063
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0045860 positive regulation of protein kinase activity IMP 19829063
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Pathways by source and SIGNOR curated interactions for CACUL1 Gene

Drugs & Compounds for CACUL1 Gene

(2) Drugs for CACUL1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
cysteine Nutra 143
genes like me logo Genes that share compounds with CACUL1: view

Transcripts for CACUL1 Gene

Unigene Clusters for CACUL1 Gene

CDK2-associated, cullin domain 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACUL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CACUL1 Gene

GeneLoc Exon Structure for
CACUL1
ECgene alternative splicing isoforms for
CACUL1

Expression for CACUL1 Gene

mRNA expression in normal human tissues for CACUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CACUL1 Gene

This gene is overexpressed in Frontal cortex (29.4), Placenta (18.2), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACUL1 Gene



SOURCE GeneReport for Unigene cluster for CACUL1 Gene Hs.420024

mRNA Expression by UniProt/SwissProt for CACUL1 Gene

Q86Y37-CACL1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.
genes like me logo Genes that share expression patterns with CACUL1: view

Protein tissue co-expression partners for CACUL1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CACUL1 Gene

Orthologs for CACUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACUL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACUL1 35
  • 94.34 (n)
  • 96.03 (a)
CACUL1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACUL1 35
  • 97.15 (n)
  • 99.19 (a)
CACUL1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacul1 35
  • 90.38 (n)
  • 94.12 (a)
Cacul1 16
Cacul1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACUL1 35
  • 99.64 (n)
  • 99.46 (a)
CACUL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacul1 35
  • 89.3 (n)
  • 93.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CACUL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACUL1 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF46 35
  • 84.65 (n)
  • 85.15 (a)
C6H10ORF46 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cacul1 35
  • 73.54 (n)
  • 80.07 (a)
Str.1045 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13083 35
zebrafish
(Danio rerio)
Actinopterygii LOC100538081 35
  • 68.64 (n)
  • 68.35 (a)
CACUL1 36
  • 61 (a)
OneToOne
Species with no ortholog for CACUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACUL1 Gene

ENSEMBL:
Gene Tree for CACUL1 (if available)
TreeFam:
Gene Tree for CACUL1 (if available)

Paralogs for CACUL1 Gene

No data available for Paralogs for CACUL1 Gene

Variants for CACUL1 Gene

Sequence variations from dbSNP and Humsavar for CACUL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3303 -- 118,687,917(+) GTTCA(C/T)CCCAC intron-variant
rs12440 -- 118,686,602(-) TTGGC(C/T)TATAG synonymous-codon, reference, nc-transcript-variant
rs752483 -- 118,686,282(-) TTAAG(C/G/T)CTTTT intron-variant
rs754806 -- 118,673,708(+) CCCTG(A/G)CCTGA nc-transcript-variant
rs754807 -- 118,673,740(+) GCCCT(A/C/G)GTGCC nc-transcript-variant

Variation tolerance for CACUL1 Gene

Residual Variation Intolerance Score: 24.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACUL1 Gene

HapMap Linkage Disequilibrium report
CACUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CACUL1 Gene

Disorders for CACUL1 Gene

Relevant External Links for CACUL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACUL1
genes like me logo Genes that share disorders with CACUL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CACUL1 Gene

Publications for CACUL1 Gene

  1. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PMID: 19829063) Kong Y. … Yin Y. (Cell Cycle 2009) 2 23 67
  2. Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. (PMID: 20005570) Gascoin-Lachambre G. … Barbaux S. (Placenta 2010) 23 67
  3. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang D.T. … Schulman B.A. (Mol. Cell 2009) 23 67
  4. The unique Morgue ubiquitination protein is conserved in a diverse but restricted set of invertebrates. (PMID: 19602541) Zhou Y. … Nambu J.R. (Mol. Biol. Evol. 2009) 23 67
  5. Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome. (PMID: 19855832) Djagaeva I. … Doronkin S. (PLoS ONE 2009) 23 67

Products for CACUL1 Gene

Sources for CACUL1 Gene

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