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CACUL1 Gene

protein-coding   GIFtS: 40
GCID: GC10M120433

CDK2-Associated, Cullin Domain 1

(Previous name: chromosome 10 open reading frame 46)
(Previous symbol: C10orf46)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDK2-Associated, Cullin Domain 11 2     Chromosome 10 Open Reading Frame 461
C10orf461 2 3     CDK2-Associated And Cullin Domain-Containing Protein 12
Cdk-Associated Cullin11 2 3     cullin2
CAC12 3     

External Ids:    HGNC: 237271   Entrez Gene: 1433842   Ensembl: ENSG000001518937   UniProtKB: Q86Y373   

Export aliases for CACUL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CACUL1 Gene:
CACUL1 (CDK2-associated, cullin domain 1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37
Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at
the G1/S phase transition




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CACUL1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCACUL1 promoter sequence
   Search Chromatin IP Primers for CACUL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACUL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

CACUL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACUL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M120433:  view genomic region     (about GC identifiers)

Start:
120,433,679 bp from pter      End:
120,514,761 bp from pter
Size:
81,083 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37 (See protein sequence)
Recommended Name: CDK2-associated and cullin domain-containing protein 1  
Size: 369 amino acids; 41064 Da
Subunit: Interacts with CDK2
Sequence caution: Sequence=AAU89709.1; Type=Frameshift; Positions=296;
Secondary accessions: Q5XPL7 Q8IY11 Q8N7S4
Alternative splicing: 3 isoforms:  Q86Y37-1   Q86Y37-2   Q86Y37-4   

Explore the universe of human proteins at neXtProt for CACUL1: NX_Q86Y37

Explore proteomics data for CACUL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CACUL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_722517.3  
    ENSEMBL proteins: 
     ENSP00000358147   ENSP00000431329   ENSP00000342487  

    CACUL1 Human Recombinant Protein Products:

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    Novus Biologicals CACUL1 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CACUL1 

     
    antibodies-online proteins for CACUL1 (4 products) 

     
    antibodies-online peptides for CACUL1

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    antibodies-online antibodies for CACUL1 (31 products) 

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for CACUL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016159 Cullin_repeat-like_dom
     IPR001373 Cullin_N

    Graphical View of Domain Structure for InterPro Entry Q86Y37

    ProtoNet protein and cluster: Q86Y37

    UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37
    Similarity: Belongs to the cullin family


    Find genes that share domains with CACUL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACL1_HUMAN, Q86Y37
    Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at
    the G1/S phase transition

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI19829063
    GO:0031625ubiquitin protein ligase binding IEA--
         
    Find genes that share ontologies with CACUL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CACUL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CACUL1:
    hsa-mir-106b-3p (MIRT038577), hsa-mir-92a-3p (MIRT049767), hsa-mir-124-3p (MIRT022907)

    Block miRNA regulation of human, mouse, rat CACUL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CACUL1
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    Predesigned siRNA for gene silencing in human, mouse, rat CACUL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACUL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031461cullin-RING ubiquitin ligase complex IEA--

    Find genes that share ontologies with CACUL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CACUL1
    Interactions:

        Search GeneGlobe Interaction Network for CACUL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CACUL1 (Q86Y371, 2 ENSP000003581474) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033721, 2EBI-8168227,EBI-78473 MINT-8401500 MINT-8401185 MINT-8401518 MINT-8401256 MINT-8401279
    KDM1AO603412MINT-8401306
    ABTB1ENSP000002327444STRING: ENSP00000232744
    FBXO9ENSP000002444264STRING: ENSP00000244426
    DPY30ENSP000002950664STRING: ENSP00000295066
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP19829063
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0008284positive regulation of cell proliferation IMP19829063
    GO:0045860positive regulation of protein kinase activity IMP19829063

    Find genes that share ontologies with CACUL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CACUL1 (CACL1)

    2 Novoseek inferred chemical compound relationships for CACUL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 11.2 3 16636053 (2), 18562529 (1)
    cysteine 6.08 1 19602541 (1)



    Find genes that share compounds with CACUL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CACUL1 gene: 
    NM_153810.4  

    Unigene Cluster for CACUL1:

    CDK2-associated, cullin domain 1
    Hs.420024  [show with all ESTs]
    Unigene Representative Sequence: NM_153810
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544392 ENST00000369151(uc001lds.1) ENST00000493518(uc010qst.1)
    ENST00000490610 ENST00000489169 ENST00000481360 ENST00000477583 ENST00000340214

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CACUL1
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    GenScript Custom all cDNA clones Services for CACUL1
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    Primer
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    OriGene qPCR primer pairs and template standards for CACUL1
    OriGene qSTAR qPCR primer pairs in human, mouse for CACUL1
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      QuantiTect SYBR Green Assays in human, mouse, rat CACUL1
      QuantiFast Probe-based Assays in human, mouse, rat CACUL1

    Additional mRNA sequence: 

    AJ544771.1 AK026985.1 AK057742.1 AK131008.1 AK301182.1 AY743663.1 

    12 DOTS entries:

    DT.115696  DT.80100935  DT.100776827  DT.91709045  DT.100751365  DT.100776831  DT.100776832  DT.121212390 
    DT.40110811  DT.75172355  DT.95370475  DT.91740587 

    Selected AceView cDNA sequences (see all 344):

    BG235976 AA830160 AI189419 AA404669 CD675554 AI805703 AI693263 AI973057 
    AI222487 BQ049552 AI217826 AA477392 AA044839 BX477578 AA648460 AA913472 
    BM021295 AA044814 BF063061 AI795966 AA010348 W15541 CK904202 Z42099 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                -                                   -                           
    SP2:                                -                             -     -                           
    SP3:                                                              -     -           -               
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CACUL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CACUL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CACUL1 Expression
    About this image

    CACUL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CACUL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420024

    UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37
    Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine.
    Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in
    G1/S, low in the middle of S phase, and increases again in S/G2 phase

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACUL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CACUL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacul11 , 5 RIKEN cDNA 2700078E11 gene5
    CDK2 associated, cullin domain 11
    90.38(n)1
    94.12(a)1
      19 (56.52 cM)5
    788321  NM_030197.21  NP_084473.11 
     605246965 
    chicken
    (Gallus gallus)
    Aves C6H10ORF461 chromosome 6 open reading frame, human C10orf46 84.65(n)
    85.15(a)
      423926  NM_001031238.1  NP_001026409.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    83(a)
    71(a)
    many → 1
    many → 1
    1(249380156-249380597)
    GL343399.1(60743-109865)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.130832 Xenopus laevis transcribed sequences 77.28(n)    BJ093987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005380811 CDK2-associated and cullin domain-containing protein more 68.64(n)
    68.35(a)
      100538081  XM_003199759.2  XP_003199807.2 


    ENSEMBL Gene Tree for CACUL1 (if available)
    TreeFam Gene Tree for CACUL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CACUL1 (see all 1440)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734239121,2
    C,F--120440163(+) AAGGTC/TCACAG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1436571631,2
    C--120440180(+) CTGTAC/GAGTGT 1 -- int10--------
    rs1450114261,2
    --120440219(+) ATATCC/TGTATC 1 -- int10--------
    rs1890213891,2
    --120440220(+) TATCCA/GTATCC 1 -- int10--------
    rs1925001471,2
    --120440332(+) GCTAAA/GTAACT 1 -- int10--------
    rs1490923411,2
    C--120440351(+) AGATGG/TGTGCT 1 -- int10--------
    rs1841946511,2
    --120440459(+) CAAGGA/CCATCT 1 -- int10--------
    rs744399581,2
    F--120440499(+) GCCAAC/TGACAT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1431250651,2
    --120440590(+) CACCAA/TAAGAT 1 -- ut310--------
    rs1512332841,2
    --120440646(+) TCATCC/TGCCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CACUL1 (120433679 - 120514761 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CACUL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CACUL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CACUL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CACUL1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CACUL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11673459 (1)


    Export disorders for CACUL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CACUL1 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with CACUL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PubMed id 19829063)1, 2, 3, 9 Kong Y.... Yin Y. (Cell Cycle 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells. (PubMed id 23806693)1 Chen T.J....Chen M.W. (Biochem. Biophys. Res. Commun. 2013)
    7. CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line. (PubMed id 23311997)1 Zheng Q....Liao Z.J. (World J Surg Oncol 2013)
    8. Negative regulation of ERI+ by a novel protein CAC1 through association with histone demethylase LSD1. (PubMed id 23178685)1 Kim J....Kim E.J. (FEBS Lett. 2013)
    9. CAC1 negatively regulates RARI+ activity through cooperation with HDAC. (PubMed id 22982681)1 Moon M....Kim E.J. (Biochem. Biophys. Res. Commun. 2012)
    10. The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. (PubMed id 22903020)1 Kong Y....Qi X.G. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 143384 HGNC: 23727 AceView: C10orf46 Ensembl:ENSG00000151893 euGenes: HUgn143384
    ECgene: CACUL1 H-InvDB: CACUL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CACUL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CACUL1 gene:
    Search GeneIP for patents involving CACUL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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