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Aliases for CACUL1 Gene

Aliases for CACUL1 Gene

  • CDK2 Associated Cullin Domain 1 2 3 5
  • Cdk-Associated Cullin1 2 3 4
  • C10orf46 3 4
  • CAC1 3 4
  • CDK2-Associated And Cullin Domain-Containing Protein 1 3
  • Chromosome 10 Open Reading Frame 46 2
  • CDK2-Associated, Cullin Domain 1 2
  • Cullin 3

External Ids for CACUL1 Gene

Previous HGNC Symbols for CACUL1 Gene

  • C10orf46

Previous GeneCards Identifiers for CACUL1 Gene

  • GC10M120433

Summaries for CACUL1 Gene

GeneCards Summary for CACUL1 Gene

CACUL1 (CDK2 Associated Cullin Domain 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for CACUL1 Gene

  • Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACUL1 Gene

Genomics for CACUL1 Gene

Regulatory Elements for CACUL1 Gene

Enhancers for CACUL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F118728 0.5 Ensembl ENCODE 44.2 +20.9 20949 12.6 WRNIP1 ZFP64 INSM2 KLF17 FEZF1 ZNF2 RAD21 ZBTB40 SCRT2 ZNF391 CACUL1 PRLHR GC10P118694
GH10F118725 0.7 Ensembl ENCODE 42.9 +29.0 28968 0.9 INSM2 FEZF1 ZNF2 ZNF366 ZNF391 OVOL3 TSHZ1 ZEB2 ZNF518A ZNF843 CACUL1 PRLHR GC10P118694
GH10F118743 0.6 Ensembl ENCODE 35.1 +10.5 10549 2.2 ZNF202 JUN CEBPB FEZF1 ZIC2 EP300 ZFP69B GTF3C2 GLIS2 ZNF692 CACUL1 RPL17P36 ENSG00000231104 GC10P118694
GH10F118701 0.4 ENCODE 32.8 +53.1 53064 1.0 SIN3A EBF1 GABPA FOSL1 ZFHX2 ATF3 IKZF1 PRDM10 FOS EGR2 CACUL1 GC10P118694
GH10F118692 1.2 Ensembl ENCODE 32.5 +62.1 62089 0.9 JUND SIN3A FOS MAFK CACUL1 ENSG00000277687 TOMM22P5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CACUL1 on UCSC Golden Path with GeneCards custom track

Promoters for CACUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000362647 949 3401 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS KLF13

Genomic Location for CACUL1 Gene

Chromosome:
10
Start:
118,672,993 bp from pter
End:
118,755,249 bp from pter
Size:
82,257 bases
Orientation:
Minus strand

Genomic View for CACUL1 Gene

Genes around CACUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACUL1 Gene

Proteins for CACUL1 Gene

  • Protein details for CACUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y37-CACL1_HUMAN
    Recommended name:
    CDK2-associated and cullin domain-containing protein 1
    Protein Accession:
    Q86Y37
    Secondary Accessions:
    • Q5XPL7
    • Q8IY11
    • Q8N7S4

    Protein attributes for CACUL1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41064 Da
    Quaternary structure:
    • Interacts with CDK2.
    SequenceCaution:
    • Sequence=AAU89709.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305};

    Alternative splice isoforms for CACUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACUL1 Gene

Post-translational modifications for CACUL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACUL1 Gene

Domains & Families for CACUL1 Gene

Protein Domains for CACUL1 Gene

Suggested Antigen Peptide Sequences for CACUL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y37

UniProtKB/Swiss-Prot:

CACL1_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CACUL1: view

No data available for Gene Families for CACUL1 Gene

Function for CACUL1 Gene

Molecular function for CACUL1 Gene

UniProtKB/Swiss-Prot Function:
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

Gene Ontology (GO) - Molecular Function for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23178685
GO:0019901 protein kinase binding IPI 19829063
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CACUL1: view
genes like me logo Genes that share phenotypes with CACUL1: view

Animal Model Products

miRNA for CACUL1 Gene

miRTarBase miRNAs that target CACUL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CACUL1 Gene

Localization for CACUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACUL1 Gene COMPARTMENTS Subcellular localization image for CACUL1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IBA --
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CACUL1 Gene

Pathways & Interactions for CACUL1 Gene

SuperPathways for CACUL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 19829063
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 19829063
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Pathways by source and SIGNOR curated interactions for CACUL1 Gene

Drugs & Compounds for CACUL1 Gene

(2) Drugs for CACUL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CACUL1: view

Transcripts for CACUL1 Gene

Unigene Clusters for CACUL1 Gene

CDK2-associated, cullin domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CACUL1 Gene

GeneLoc Exon Structure for
CACUL1
ECgene alternative splicing isoforms for
CACUL1

Expression for CACUL1 Gene

mRNA expression in normal human tissues for CACUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CACUL1 Gene

This gene is overexpressed in Frontal cortex (29.4), Placenta (18.2), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CACUL1 Gene



Protein tissue co-expression partners for CACUL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CACUL1 Gene:

CACUL1

SOURCE GeneReport for Unigene cluster for CACUL1 Gene:

Hs.420024

mRNA Expression by UniProt/SwissProt for CACUL1 Gene:

Q86Y37-CACL1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.
genes like me logo Genes that share expression patterns with CACUL1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CACUL1 Gene

Orthologs for CACUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACUL1 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia CACUL1 34 35
  • 97.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CACUL1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACUL1 34 35
  • 94.34 (n)
mouse
(Mus musculus)
Mammalia Cacul1 34 16 35
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Cacul1 34
  • 89.3 (n)
oppossum
(Monodelphis domestica)
Mammalia CACUL1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF46 34 35
  • 84.65 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cacul1 34
  • 73.54 (n)
Str.1045 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13083 34
zebrafish
(Danio rerio)
Actinopterygii LOC100538081 34
  • 68.64 (n)
CACUL1 35
  • 61 (a)
OneToOne
Species where no ortholog for CACUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACUL1 Gene

ENSEMBL:
Gene Tree for CACUL1 (if available)
TreeFam:
Gene Tree for CACUL1 (if available)

Paralogs for CACUL1 Gene

No data available for Paralogs for CACUL1 Gene

Variants for CACUL1 Gene

Sequence variations from dbSNP and Humsavar for CACUL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1045846 -- 118,682,655(-) CGCAA(A/T)ATTCT utr-variant-3-prime
rs1045891 -- 118,681,221(-) TTCCT(A/G)GTGGT utr-variant-3-prime
rs10510046 -- 118,693,656(+) GCACT(C/T)AGATG intron-variant
rs10510047 -- 118,730,583(+) TCAAG(A/G)ATGTT intron-variant
rs10510048 -- 118,738,224(+) GAAGA(C/T)GCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACUL1 Gene

Variant ID Type Subtype PubMed ID
esv3579147 CNV loss 25503493
nsv1041093 CNV gain 25217958
nsv24391 CNV insertion 16902084
nsv832006 CNV gain 17160897
nsv951862 CNV duplication 24416366

Variation tolerance for CACUL1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACUL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CACUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACUL1 Gene

Disorders for CACUL1 Gene

Relevant External Links for CACUL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACUL1

No disorders were found for CACUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CACUL1 Gene

Publications for CACUL1 Gene

  1. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PMID: 19829063) Kong Y. … Yin Y. (Cell Cycle 2009) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1). (PMID: 26314198) Ma H.L. … Dang C.X. (Cell. Mol. Biol. (Noisy-le-grand) 2015) 3 64

Products for CACUL1 Gene

Sources for CACUL1 Gene

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