CACUL1 Gene
protein-coding GIFtS: 40
GCID: GC10M120433
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CDK2-associated, cullin domain 1(Previous name: chromosome 10 open reading frame 46 )
(Previous symbol: C10orf46)
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Aliases
for CACUL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDK2-Associated, Cullin Domain 11 2 | | MGC332151 | | C10orf461 2 3 | | Chromosome 10 Open Reading Frame 461 | | CAC11 2 3 | | CDK2-Associated And Cullin Domain-Containing Protein 12 | | Cdk-Associated Cullin12 3 | | Cullin1 | | FLJ404091 | | |
Export aliases for CACUL1 gene to outside databases |
Summaries
for CACUL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at theG1/S phase transition
|
Genomic Views
for CACUL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CACUL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CACUL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACUL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.13CACUL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M120433: view genomic region
(about GC identifiers)
Start:
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120,433,679 bp from pter |
End:
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120,514,761 bp from pter |
Size:
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81,083 bases |
Orientation:
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minus strand |
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Proteins
for CACUL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37 (See
protein sequence)Recommended Name: CDK2-associated and cullin domain-containing protein 1 Size: 369 amino acids; 41064 Da
Subunit: Interacts with CDK2
Sequence caution: Sequence=AAU89709.1; Type=Frameshift; Positions=296;
Secondary accessions: Q5XPL7 Q8IY11 Q8N7S4Alternative splicing: 3 isoforms: Q86Y37-1 Q86Y37-2 Q86Y37-4 Explore the universe of human proteins at neXtProt for CACUL1: NX_Q86Y37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y37
CACUL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_722517.3
ENSEMBL proteins: ENSP00000358152 ENSP00000431329 ENSP00000358147 ENSP00000443048 ENSP00000342487
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031461 | cullin-RING ubiquitin ligase complex |
IEA | -- |
CACUL1 for ontologies About GeneDecksing
CACUL1 Antibody Products:
Assay Products for CACUL1: |
Protein
Domains /
Families
for CACUL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CACUL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y37ProtoNet protein and cluster: Q86Y37 UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37Similarity: Belongs to the cullin family |
Function
for CACUL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at theG1/S phase transition
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CACUL1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACUL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACUL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACUL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CACUL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CACUL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACUL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for CACUL1 (Q86Y372 ENSP000003581474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CACUL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CACUL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CACUL1 for compounds About GeneDecksing
 Browse Tocris compounds for CACUL1
2 Novoseek chemical compound relationships for CACUL1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
11.2 |
3 |
16636053 (2), 18562529 (1) |
| cysteine |
6.08 |
1 |
19602541 (1) |
Search CenterWatch for drugs/clinical trials and news about CACUL1 / CACL1
|
Transcripts
for CACUL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CACUL1 gene: NM_153810.4 Unigene Cluster for CACUL1: CDK2-associated, cullin domain 1 Hs.420024 [show with all ESTs]Unigene Representative Sequence: NM_15381010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369156 ENST00000483833 ENST00000493518(uc010qst.1) ENST00000490610
ENST00000489169 ENST00000481360 ENST00000477583 ENST00000369151(uc001lds.1)
ENST00000544392 ENST00000340214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CACUL1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACUL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACUL1 |
Additional cDNA sequence: AJ544771.1 AK026985.1 AK057742.1 AK131008.1 AK301182.1 AY743663.1 12 DOTS entries: DT.115696 DT.80100935 DT.100776827 DT.91709045 DT.100751365 DT.100776831 DT.100776832 DT.121212390 DT.40110811 DT.75172355 DT.95370475 DT.91740587 24/344 AceView cDNA sequences (see all 344): BG568782 AA402343 AI394511 AI394004 AI222487 AA459900 AI693263 W31635 AI491931 NM_153810 Z38368 AA825521 AI209112 BX477578 BU623607 BG235976 AA044839 AI265943 AI004465 CA503363 N75940 AA913472 AA569396 AA010348
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CACUL1
|
Expression
for CACUL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See CACUL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACUL1
SOURCE GeneReport for Unigene cluster: Hs.420024
UniProtKB/Swiss-Prot: CACL1_HUMAN, Q86Y37Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highlyexpressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low inthe middle of S phase, and increases again in S/G2 phase
SABiosciences Custom PCR Arrays for CACUL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACUL1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CACUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACUL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACUL1 |
Orthologs
for CACUL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CACUL1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for CACUL1 (if available)
TreeFam Gene Tree for CACUL1 (if available) |
Paralogs
for CACUL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CACUL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CACUL1 (120433679 - 120514761 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CACUL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACUL1 |
|
Disorders
/ Diseases
for CACUL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CACUL1 for disorders About GeneDecksing
7  diseases for CACUL1: About MalaCardsoral squamous cell carcinoma squamous cell carcinoma renal cell carcinoma breast cancer
hypoxia immunodeficiency carcinoma
1 Novoseek disease relationship for CACUL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
11673459 (1) |
Export disorders for CACUL1 gene to outside databases
|
Publications
for CACUL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CACUL1 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with CACUL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of CAC1 as a nove l CDK2-associated cullin. (PubMed id 19829063)1, 2, 3, 9 Kong Y....Yin Y. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of the newly identified gene CAC1 in the hi ppocampus of Alzheimer's disease patients. (PubMed id 22415352)1 Kong Y....Nan K.J. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Cullins in human intra-uterine growth restriction: ex pressional and epigenetic alterations. (PubMed id 20005570)9 Gascoin-Lachambre G....Barbaux S. (2010)
|
External Searches for CACUL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CACUL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CACUL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CACUL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CACUL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CACUL1 gene:
Search GeneIP for patents involving CACUL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CACUL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CACUL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACUL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACUL1 | | | OriGene Protein Over-expression Lysate for CACUL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CACUL1 | | OriGene 3'-UTR Clone for CACUL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACUL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CACUL1 | | OriGene Custom Protein Services for CACUL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACUL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACUL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACUL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACUL1 |
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 |  |  |  | |
| | | | Search Tocris compounds for CACUL1 |
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 | | | CACUL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACUL1 |
|  |  |  | | | | ThermoFisher Antibodies for CACUL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACUL1 |
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