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Aliases for CACUL1 Gene

Aliases for CACUL1 Gene

  • CDK2 Associated Cullin Domain 1 2 3
  • CDK2-Associated, Cullin Domain 1 2 3 5
  • Cdk-Associated Cullin1 2 3 4
  • C10orf46 3 4
  • CAC1 3 4
  • Chromosome 10 Open Reading Frame 46 2
  • Cullin 3

External Ids for CACUL1 Gene

Previous HGNC Symbols for CACUL1 Gene

  • C10orf46

Previous GeneCards Identifiers for CACUL1 Gene

  • GC10M120433

Summaries for CACUL1 Gene

GeneCards Summary for CACUL1 Gene

CACUL1 (CDK2 Associated Cullin Domain 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for CACUL1 Gene

  • Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACUL1 Gene

Genomics for CACUL1 Gene

Regulatory Elements for CACUL1 Gene

Enhancers for CACUL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CACUL1 on UCSC Golden Path with GeneCards custom track

Promoters for CACUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CACUL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CACUL1 Gene

118,672,993 bp from pter
118,755,249 bp from pter
82,257 bases
Minus strand

Genomic View for CACUL1 Gene

Genes around CACUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACUL1 Gene

Proteins for CACUL1 Gene

  • Protein details for CACUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDK2-associated and cullin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5XPL7
    • Q8IY11
    • Q8N7S4

    Protein attributes for CACUL1 Gene

    369 amino acids
    Molecular mass:
    41064 Da
    Quaternary structure:
    • Interacts with CDK2.
    • Sequence=AAU89709.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305};

    Alternative splice isoforms for CACUL1 Gene


neXtProt entry for CACUL1 Gene

Proteomics data for CACUL1 Gene at MOPED

Post-translational modifications for CACUL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACUL1 Gene

Domains & Families for CACUL1 Gene

Protein Domains for CACUL1 Gene


Suggested Antigen Peptide Sequences for CACUL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cullin family.
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CACUL1: view

No data available for Gene Families for CACUL1 Gene

Function for CACUL1 Gene

Molecular function for CACUL1 Gene

UniProtKB/Swiss-Prot Function:
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

Gene Ontology (GO) - Molecular Function for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 19829063
GO:0031625 ubiquitin protein ligase binding IEA,IBA --
genes like me logo Genes that share ontologies with CACUL1: view
genes like me logo Genes that share phenotypes with CACUL1: view

Animal Model Products

miRNA for CACUL1 Gene

miRTarBase miRNAs that target CACUL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CACUL1 Gene

Localization for CACUL1 Gene

Subcellular locations from

Jensen Localization Image for CACUL1 Gene COMPARTMENTS Subcellular localization image for CACUL1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CACUL1 Gene

Pathways & Interactions for CACUL1 Gene

SuperPathways for CACUL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 19829063
GO:0008284 positive regulation of cell proliferation IMP 19829063
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Pathways by source and SIGNOR curated interactions for CACUL1 Gene

Drugs & Compounds for CACUL1 Gene

(2) Drugs for CACUL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CACUL1: view

Transcripts for CACUL1 Gene

Unigene Clusters for CACUL1 Gene

CDK2-associated, cullin domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -

Relevant External Links for CACUL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CACUL1 Gene

mRNA expression in normal human tissues for CACUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CACUL1 Gene

This gene is overexpressed in Frontal cortex (29.4), Placenta (18.2), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACUL1 Gene

SOURCE GeneReport for Unigene cluster for CACUL1 Gene Hs.420024

mRNA Expression by UniProt/SwissProt for CACUL1 Gene

Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.
genes like me logo Genes that share expression patterns with CACUL1: view

Protein tissue co-expression partners for CACUL1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for CACUL1 Gene

Orthologs for CACUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACUL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CACUL1 35
  • 94.34 (n)
  • 96.03 (a)
  • 81 (a)
(Canis familiaris)
Mammalia CACUL1 35
  • 97.15 (n)
  • 99.19 (a)
  • 96 (a)
(Mus musculus)
Mammalia Cacul1 35
  • 90.38 (n)
  • 94.12 (a)
Cacul1 16
Cacul1 36
  • 92 (a)
(Pan troglodytes)
Mammalia CACUL1 35
  • 99.64 (n)
  • 99.46 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cacul1 35
  • 89.3 (n)
  • 93.27 (a)
(Monodelphis domestica)
Mammalia CACUL1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CACUL1 36
  • 97 (a)
(Gallus gallus)
Aves C6H10ORF46 35
  • 84.65 (n)
  • 85.15 (a)
C6H10ORF46 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
-- 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cacul1 35
  • 73.54 (n)
  • 80.07 (a)
Str.1045 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13083 35
(Danio rerio)
Actinopterygii LOC100538081 35
  • 68.64 (n)
  • 68.35 (a)
  • 61 (a)
Species with no ortholog for CACUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACUL1 Gene

Gene Tree for CACUL1 (if available)
Gene Tree for CACUL1 (if available)

Paralogs for CACUL1 Gene

No data available for Paralogs for CACUL1 Gene

Variants for CACUL1 Gene

Sequence variations from dbSNP and Humsavar for CACUL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1543577 -- 118,742,305(+) GACAT(A/G)CCATA intron-variant
rs1543578 -- 118,738,067(-) TGGGC(A/T)TAATG intron-variant
rs3303 -- 118,687,917(+) GTTCA(C/T)CCCAC intron-variant
rs12440 -- 118,686,602(-) TTGGC(C/T)TATAG nc-transcript-variant, reference, synonymous-codon
rs1886897 -- 118,693,142(-) ATTCT(C/G)ATGAC intron-variant, utr-variant-3-prime

Variation tolerance for CACUL1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CACUL1 Gene

Disorders for CACUL1 Gene

Relevant External Links for CACUL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CACUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CACUL1 Gene

Publications for CACUL1 Gene

  1. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PMID: 19829063) Kong Y. … Yin Y. (Cell Cycle 2009) 2 3 4 23 67
  2. Negative regulation of ERI+ by a novel protein CAC1 through association with histone demethylase LSD1. (PMID: 23178685) Kim J. … Kim E.J. (FEBS Lett. 2013) 3
  3. CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line. (PMID: 23311997) Zheng Q. … Liao Z.J. (World J Surg Oncol 2013) 3
  4. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells. (PMID: 23806693) Chen T.J. … Chen M.W. (Biochem. Biophys. Res. Commun. 2013) 3
  5. Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1. (PMID: 24004834) Kong Y. … Nan K.J. (Int. J. Biochem. Cell Biol. 2013) 3

Products for CACUL1 Gene

Sources for CACUL1 Gene