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Aliases for CACUL1 Gene

Aliases for CACUL1 Gene

  • CDK2-Associated, Cullin Domain 1 2 3
  • Cdk-Associated Cullin1 2 3 4
  • C10orf46 3 4
  • CAC1 3 4
  • CDK2-Associated And Cullin Domain-Containing Protein 1 3
  • Chromosome 10 Open Reading Frame 46 2
  • Cullin 3

External Ids for CACUL1 Gene

Previous HGNC Symbols for CACUL1 Gene

  • C10orf46

Previous GeneCards Identifiers for CACUL1 Gene

  • GC10M120433

Summaries for CACUL1 Gene

GeneCards Summary for CACUL1 Gene

CACUL1 (CDK2-Associated, Cullin Domain 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for CACUL1 Gene

  • Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACUL1 Gene

Genomics for CACUL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACUL1 Gene

Start:
118,674,167 bp from pter
End:
118,755,249 bp from pter
Size:
81,083 bases
Orientation:
Minus strand

Genomic View for CACUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACUL1 Gene

No data available for Regulatory Elements for CACUL1 Gene

Proteins for CACUL1 Gene

  • Protein details for CACUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y37-CACL1_HUMAN
    Recommended name:
    CDK2-associated and cullin domain-containing protein 1
    Protein Accession:
    Q86Y37
    Secondary Accessions:
    • Q5XPL7
    • Q8IY11
    • Q8N7S4

    Protein attributes for CACUL1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41064 Da
    Quaternary structure:
    • Interacts with CDK2.
    SequenceCaution:
    • Sequence=AAU89709.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305};

    Alternative splice isoforms for CACUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACUL1 Gene

Proteomics data for CACUL1 Gene at MOPED

Post-translational modifications for CACUL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACUL1 Gene

Domains for CACUL1 Gene

Protein Domains for CACUL1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86Y37

UniProtKB/Swiss-Prot:

CACL1_HUMAN :
  • Q86Y37
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CACUL1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CACUL1 Gene

Function for CACUL1 Gene

Molecular function for CACUL1 Gene

UniProtKB/Swiss-Prot Function: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.

Gene Ontology (GO) - Molecular Function for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23178685
GO:0019901 protein kinase binding IPI 19829063
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CACUL1: view

Animal Model Products

CRISPR Products

miRNA for CACUL1 Gene

miRTarBase miRNAs that target CACUL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACUL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CACUL1 Gene

Localization for CACUL1 Gene

Gene Ontology (GO) - Cellular Components for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031461 cullin-RING ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CACUL1 Gene

Pathways for CACUL1 Gene

SuperPathways for CACUL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 19829063
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0008284 positive regulation of cell proliferation IMP 19829063
GO:0045860 positive regulation of protein kinase activity IMP 19829063
genes like me logo Genes that share ontologies with CACUL1: view

No data available for Pathways by source for CACUL1 Gene

Compounds for CACUL1 Gene

(2) Novoseek inferred chemical compound relationships for CACUL1 Gene

Compound -log(P) Hits PubMed IDs
zinc 11.2 3
cysteine 6.08 1
genes like me logo Genes that share compounds with CACUL1: view

Transcripts for CACUL1 Gene

Unigene Clusters for CACUL1 Gene

CDK2-associated, cullin domain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACUL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CACUL1 Gene

GeneLoc Exon Structure for
CACUL1
ECgene alternative splicing isoforms for
CACUL1

Expression for CACUL1 Gene

mRNA expression in normal human tissues for CACUL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACUL1 Gene

SOURCE GeneReport for Unigene cluster for CACUL1 Gene Hs.420024

mRNA Expression by UniProt/SwissProt for CACUL1 Gene

Q86Y37-CACL1_HUMAN
Tissue specificity: Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.
genes like me logo Genes that share expressions with CACUL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CACUL1 Gene

Orthologs for CACUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACUL1 35
  • 99.64 (n)
  • 99.46 (a)
CACUL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACUL1 35
  • 94.34 (n)
  • 96.03 (a)
CACUL1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACUL1 35
  • 97.15 (n)
  • 99.19 (a)
CACUL1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacul1 35
  • 90.38 (n)
  • 94.12 (a)
Cacul1 16
Cacul1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACUL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACUL1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacul1 35
  • 89.3 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves C6H10ORF46 35
  • 84.65 (n)
  • 85.15 (a)
C6H10ORF46 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.13083 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cacul1 35
  • 73.54 (n)
  • 80.07 (a)
Str.1045 35
zebrafish
(Danio rerio)
Actinopterygii CACUL1 36
  • 61 (a)
OneToOne
LOC100538081 35
  • 68.64 (n)
  • 68.35 (a)
Species with no ortholog for CACUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACUL1 Gene

ENSEMBL:
Gene Tree for CACUL1 (if available)
TreeFam:
Gene Tree for CACUL1 (if available)

Paralogs for CACUL1 Gene

No data available for Paralogs for CACUL1 Gene

Variants for CACUL1 Gene

Sequence variations from dbSNP and Humsavar for CACUL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3303 -- 118,687,917(+) GTTCA(C/T)CCCAC intron-variant
rs12440 -- 118,686,602(-) TTGGC(C/T)TATAG synonymous-codon, reference, nc-transcript-variant
rs752483 -- 118,686,282(-) TTAAG(C/T)CTTTT intron-variant
rs754806 -- 118,673,708(+) CCCTG(A/G)CCTGA downstream-variant-500B
rs754807 -- 118,673,740(+) GCCCT(A/G)GTGCC downstream-variant-500B

Relevant External Links for CACUL1 Gene

HapMap Linkage Disequilibrium report
CACUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CACUL1 Gene

Disorders for CACUL1 Gene

(1) Novoseek inferred disease relationships for CACUL1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with CACUL1: view

No data available for UniProtKB/Swiss-Prot for CACUL1 Gene

Publications for CACUL1 Gene

  1. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PMID: 19829063) Kong Y. … Yin Y. (Cell Cycle 2009) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for CACUL1 Gene

Sources for CACUL1 Gene

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