CACTIN Gene
protein-coding GIFtS: 37
GCID: GC19M003610
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cactin, spliceosome C complex subunit(Previous name: chromosome 19 open reading frame 29 )
(Previous symbol: C19orf29)
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Aliases
for CACTIN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cactin, Spliceosome C Complex Subunit1 2 | | Chromosome 19 Open Reading Frame 291 | | C19orf291 2 3 | | Cactin Homolog2 | | NY-REN-241 2 | | Functional Spliceosome-Associated Protein C2 | | Cactin1 | | NY REN 24 Antigen2 | | FSAPc1 | | NY-REN-24 Antigen2 | | Renal Carcinoma Antigen NY-REN-242 3 | | |
Export aliases for CACTIN gene to outside databases |
Summaries
for CACTIN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor andinterferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation ofNF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonicdevelopment. Probably involved in pre-mRNA splicing
Gene Wiki entry for CACTIN (C19orf29)
|
Genomic Views
for CACTIN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CACTIN
Other transcription factors
Search SABiosciences Chromatin IP Primers for CACTIN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACTIN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3CACTIN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M003610: view genomic region
(about GC identifiers)
Start:
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3,610,626 bp from pter |
End:
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3,626,813 bp from pter |
Size:
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16,188 bases |
Orientation:
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minus strand |
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Proteins
for CACTIN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7 (See
protein sequence)Recommended Name: Cactin Size: 758 amino acids; 88702 Da
Subunit: Interacts (via N-terminus domain) with NFKBIL1; the interaction occurs in a proinflammatory-independentmanner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex
Subcellular location: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizeswith NFKBIL1 in the nucleus
Miscellaneous: Antigen recognized by autologous antibody in patients with renal-cell carcinoma
Caution: An ORF (C19orf029 OS) has been described in the opposite strand of the C-terminus of this gene
Sequence caution: Sequence=AAC24305.1; Type=Erroneous gene model prediction; Sequence=AAC32903.1; Type=Erroneous genemodel prediction; Sequence=AAD42868.1; Type=Frameshift; Positions=711; Sequence=AAH04262.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=EAW69298.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NNA9 A9UL12 O75229 Q7LE08 Q9BTA6 Q9Y5A4Alternative splicing: 2 isoforms: Q8WUQ7-1 Q8WUQ7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CACTIN: NX_Q8WUQ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUQ7
CACTIN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001074012.1 NP_067054.1
ENSEMBL proteins: ENSP00000415078 ENSP00000464898 ENSP00000467149 ENSP00000465751 ENSP00000466600 ENSP00000467788 ENSP00000221899 ENSP00000248420
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CACTIN for ontologies About GeneDecksing
CACTIN Antibody Products:
Assay Products for CACTIN: |
Protein
Domains /
Families
for CACTIN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CACTIN for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUQ7ProtoNet protein and cluster: Q8WUQ7 UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7Similarity: Belongs to the CACTIN family |
Function
for CACTIN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor andinterferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation ofNF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonicdevelopment. Probably involved in pre-mRNA splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CACTIN | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACTIN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACTIN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACTIN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
CACTIN for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CACTIN:
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Pathways & Interactions
for CACTIN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACTIN
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/26 Interacting proteins for CACTIN (Q8WUQ73 ENSP000002484204) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000398 | mRNA splicing, via spliceosome |
IC | 11991638 | | GO:0001933 | negative regulation of protein phosphorylation |
IMP | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway |
IMP | -- | | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
IDA | -- |
CACTIN for ontologies About GeneDecksing
|
Drugs & Compounds
for CACTIN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CACTIN
Search CenterWatch for drugs/clinical trials and news about CACTIN / CATIN
|
Transcripts
for CACTIN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CACTIN gene (2 alternative transcripts): NM_001080543.1 NM_021231.1 Unigene Cluster for CACTIN: Cactin, spliceosome C complex subunit Hs.128425 [show with all ESTs]Unigene Representative Sequence: NM_00108054310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429344(uc010xho.2 uc010dtn.3 uc002lyh.3 uc002lyi.4 uc010dto.3)
ENST00000591726 ENST00000592721 ENST00000585942 ENST00000589321 ENST00000587175
ENST00000588749 ENST00000591978 ENST00000221899 ENST00000248420(uc010xhp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CACTIN | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACTIN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACTIN |
Additional cDNA sequence: AF052087.1 AF155102.1 AK299963.1 AY917150.1 BC004262.1 BC019848.1 5 DOTS entries: DT.108025 DT.100756760 DT.422988 DT.99955429 DT.75126071
GeneLoc Exon Structure
|
Expression
for CACTIN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See CACTIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACTIN
SOURCE GeneReport for Unigene cluster: Hs.128425
SABiosciences Custom PCR Arrays for CACTIN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACTIN
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CACTIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACTIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACTIN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACTIN |
Orthologs
for CACTIN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CACTIN gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for CACTIN (if available)
TreeFam Gene Tree for CACTIN (if available) |
Paralogs
for CACTIN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CACTIN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CACTIN (3610626 - 3626813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CACTIN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACTIN |
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Disorders
/ Diseases
for CACTIN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CACTIN for disorders About GeneDecksing
4  diseases for CACTIN: About MalaCardsrenal carcinoma carcinoma renal cell carcinoma malaria
Export disorders for CACTIN gene to outside databases
|
Publications
for CACTIN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CACTIN gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CACTIN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling p athways. (PubMed id 20829348)1, 2, 3 Atzei P....Moynagh P.N. (2010)
- Evolution and comparative genomics of subcellular spe cializations: EST sequencing of Torpedo electric organ. (PubMed id 21429463)1, 3 Nazarian J....Hoffman E.P. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
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External Searches for CACTIN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CACTIN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CACTIN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CACTIN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CACTIN | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CACTIN gene:
Search GeneIP for patents involving CACTIN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CACTIN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CACTIN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACTIN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACTIN | | | OriGene Protein Over-expression Lysate for CACTIN | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CACTIN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACTIN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CACTIN | | OriGene Custom Protein Services for CACTIN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACTIN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACTIN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACTIN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACTIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACTIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACTIN |
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| | | | Search Tocris compounds for CACTIN |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACTIN |
|  |  |  | | | | ThermoFisher Antibodies for CACTIN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACTIN |
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