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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CACTIN Gene

protein-coding   GIFtS: 38
GCID: GC19M003610

Cactin, Spliceosome C Complex Subunit

(Previous name: chromosome 19 open reading frame 29)
(Previous symbol: C19orf29)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cactin, Spliceosome C Complex Subunit1 2     Chromosome 19 Open Reading Frame 291
C19orf291 2 3     NY-REN-242
Functional Spliceosome-Associated Protein C1 2     cactin2
NY REN 24 Antigen1 2     Cactin Homolog2
Renal Carcinoma Antigen NY-REN-242 3     fSAPc2
Cactin Homolog (Drosophila)1     NY-REN-24 Antigen2

External Ids:    HGNC: 299381   Entrez Gene: 585092   Ensembl: ENSG000001052987   UniProtKB: Q8WUQ73   

Export aliases for CACTIN gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CACTIN Gene: 
CACTIN (cactin, spliceosome C complex subunit) is a protein-coding gene. Diseases associated with CACTIN include renal cell carcinoma. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7
Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor
and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional
activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during
early embryonic development. Probably involved in pre-mRNA splicing

Gene Wiki entry for CACTIN (C19orf29) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CACTIN
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CACTIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACTIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CACTIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACTIN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003610:  view genomic region     (about GC identifiers)

Start:
3,610,626 bp from pter      End:
3,626,813 bp from pter
Size:
16,188 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7 (See protein sequence)
Recommended Name: Cactin  
Size: 758 amino acids; 88702 Da
Subunit: Interacts (via N-terminus domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent
manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex
Subcellular location: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells.
Colocalizes with NFKBIL1 in the nucleus
Miscellaneous: Antigen recognized by autologous antibody in patients with renal-cell carcinoma
Caution: An ORF (C19orf029 OS) has been described in the opposite strand of the C-terminus of this gene
Sequence caution: Sequence=AAC24305.1; Type=Erroneous gene model prediction; Sequence=AAC32903.1; Type=Erroneous
gene model prediction; Sequence=AAD42868.1; Type=Frameshift; Positions=711; Sequence=AAH04262.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=EAW69298.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NNA9 A9UL12 O75229 Q7LE08 Q9BTA6 Q9Y5A4
Alternative splicing: 2 isoforms:  Q8WUQ7-1   Q8WUQ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CACTIN: NX_Q8WUQ7

Explore proteomics data for CACTIN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WUQ7

  • CACTIN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CACTIN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074012.1  NP_067054.1  

    ENSEMBL proteins: 
     ENSP00000415078   ENSP00000464898   ENSP00000467149   ENSP00000465751   ENSP00000466600  
     ENSP00000467788   ENSP00000221899   ENSP00000248420  

    Human Recombinant Protein Products for CACTIN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CACTIN
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CACTIN
    GenScript Custom Purified and Recombinant Proteins Services for CACTIN
    Novus Biologicals CACTIN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15302935
    GO:0071013catalytic step 2 spliceosome IDA11991638

    CACTIN for ontologies           About GeneDecksing



    CACTIN Antibody Products: 
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    Novus Biologicals CACTIN Antibodies
    Abcam antibodies for CACTIN
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CACTIN
    LSBio Antibodies in human, mouse, rat for CACTIN 

    Assay Products for CACTIN: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CACTIN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR019134 Cactin_C
     IPR018816 Cactin_dom

    Graphical View of Domain Structure for InterPro Entry Q8WUQ7

    ProtoNet protein and cluster: Q8WUQ7

    UniProtKB/Swiss-Prot: CATIN_HUMAN, Q8WUQ7
    Similarity: Belongs to the CACTIN family


    CACTIN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATIN_HUMAN, Q8WUQ7
    Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor
    and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional
    activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during
    early embryonic development. Probably involved in pre-mRNA splicing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CACTIN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CACTIN:
     Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CACTIN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CACTIN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CACTIN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CACTIN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACTIN
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CACTIN
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CACTIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACTIN

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CACTIN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CACTIN (see all 11)
    OriGene ORF clones in mouse, rat for CACTIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CACTIN
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACTIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACTIN
    Sirion Biotech Customized lentivirus for stable overexpression of CACTIN 
                         Customized lentivirus expression plasmids for stable overexpression of CACTIN 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACTIN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACTIN

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/33 Interacting proteins for CACTIN (Q8WUQ73 ENSP000002484204) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206433O004533I2D: score=1 
    ENSG00000223465O004533I2D: score=1 
    ENSG00000226182O004533I2D: score=1 
    ENSG00000230791O004533I2D: score=1 
    ENSG00000231048O004533I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0001933negative regulation of protein phosphorylation IMP--
    GO:0007275multicellular organismal development IEA--
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IMP--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA--

    CACTIN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CACTIN (CATIN)

    Search CenterWatch for drugs/clinical trials and news about CACTIN / CATIN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CACTIN gene (2 alternative transcripts): 
    NM_001080543.1  NM_021231.1  

    Unigene Cluster for CACTIN:

    Cactin, spliceosome C complex subunit
    Hs.128425  [show with all ESTs]
    Unigene Representative Sequence: NM_001080543
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429344(uc010xho.2 uc010dtn.3 uc002lyh.3 uc002lyi.4 uc010dto.3)
    ENST00000591726 ENST00000592721 ENST00000585942 ENST00000589321 ENST00000587175
    ENST00000588749 ENST00000591978 ENST00000221899 ENST00000248420(uc010xhp.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACTIN
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CACTIN
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CACTIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACTIN
    Clone
    Products:
         
    OriGene clones in human, mouse for CACTIN (see all 11)
    OriGene ORF clones in mouse, rat for CACTIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CACTIN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACTIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACTIN
    Sirion Biotech Customized lentivirus for stable overexpression of CACTIN 
                         Customized lentivirus expression plasmids for stable overexpression of CACTIN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CACTIN
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CACTIN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACTIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACTIN

    Additional mRNA sequence: 

    AF052087.1 AF155102.1 AK299963.1 AY917150.1 BC004262.1 BC019848.1 

    5 DOTS entries:

    DT.108025  DT.100756760  DT.422988  DT.99955429  DT.75126071 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CACTIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CACTIN Expression
    About this image


    See CACTIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CACTIN

    SOURCE GeneReport for Unigene cluster: Hs.128425
        SABiosciences Custom PCR Arrays for CACTIN
    Primer
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    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CACTIN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACTIN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACTIN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACTIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CACTIN gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cactin1 , 5 RIKEN cDNA 2510012J08 gene5
    cactin, spliceosome C complex subunit1
    84.2(n)1
    88.38(a)1
      10 (39.72 cM)5
    703121  NM_027381.21  NP_081657.11 
     813211035 
    chicken
    (Gallus gallus)
    Aves CACTIN1 cactin, spliceosome C complex subunit 78.61(n)
    80.52(a)
      420073  XM_418192.3  XP_418192.3 
    lizard
    (Anolis carolinensis)
    Reptilia CACTIN6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    AAWZ02039474(21-7422)
    zebrafish
    (Danio rerio)
    Actinopterygii cactin6
    cactin
    63(a)
    1 ↔ 1
    2(50179034-50197341)
    fruit fly
    (Drosophila melanogaster)
    Insecta cactin1 CG1676-PA 59.74(n)
    53.34(a)
      33043  NM_078698.3  NP_523422.3 
    worm
    (Caenorhabditis elegans)
    Secernentea cacn-11 Protein CACN-1 49.31(n)
    42.25(a)
      175066  NM_064550.4  NP_496951.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G039101 hypothetical protein 48(n)
    43.53(a)
      839371  NM_100272.3  NP_171887.1 


    ENSEMBL Gene Tree for CACTIN (if available)
    TreeFam Gene Tree for CACTIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/376 SNPs in CACTIN are shown (see all 376)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899350911,2
    C--3614429(+) CTGCAA/GGAGGC 4 L syn10--------
    rs1807386581,2
    C--3614471(+) ACCAGC/TGCGGA 4 T A mis10--------
    rs1996358081,2
    --3614505(+) ATGACC/TTGCAG 4 Q syn10--------
    rs606514831,2
    C,F--3614538(+) AACACC/TGACTG 4 S syn16Minor allele frequency- T:0.09WA CSA NA EA EU 929
    rs1423292951,2
    C--3614598(+) GCGGGA/GTGGGG 2 -- int10--------
    rs1844049261,2
    --3614636(+) ACGTGC/TTCCTC 2 -- int10--------
    rs1892821441,2
    --3614645(+) TCCACC/TCCATC 2 -- int10--------
    rs20747921,2
    C--3614850(+) GCGTGG/TGGGAG 2 -- int14Minor allele frequency- T:0.35NA WA EA 360
    rs7689621,2
    C,F,A,H--3615164(+) CAAACA/GGCTCC 2 -- int120Minor allele frequency- G:0.41EA NS NA WA 3838
    rs1446291751,2
    --3615241(+) TCAAGC/TCCCTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CACTIN (3610626 - 3626813 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CACTIN: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CACTIN
    DNA2.0 Custom Variant and Variant Library Synthesis for CACTIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CACTIN:    About MalaCards
    renal cell carcinoma    


    CACTIN for disorders           About GeneDecksing


    Export disorders for CACTIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CACTIN gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CACTIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling p athways. (PubMed id 20829348)1, 2, 3 Atzei P....Moynagh P.N. (2010)
    2. Evolution and comparative genomics of subcellular spe cializations: EST sequencing of Torpedo electric organ. (PubMed id 21429463)1, 3 Nazarian J....Hoffman E.P. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58509 HGNC: 29938 Ensembl:ENSG00000105298 euGenes: HUgn58509 ECgene: CACTIN
    H-InvDB: CACTIN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CACTIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CACTIN gene:
    Search GeneIP for patents involving CACTIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
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