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Aliases for CACTIN Gene

Aliases for CACTIN Gene

  • Cactin, Spliceosome C Complex Subunit 2 3 5
  • Functional Spliceosome-Associated Protein C 2 3
  • Renal Carcinoma Antigen NY-REN-24 3 4
  • NY REN 24 Antigen 2 3
  • C19orf29 3 4
  • Chromosome 19 Open Reading Frame 29 2
  • Cactin Homolog (Drosophila) 2
  • NY-REN-24 3
  • FSAPc 3

External Ids for CACTIN Gene

Previous HGNC Symbols for CACTIN Gene

  • C19orf29

Summaries for CACTIN Gene

GeneCards Summary for CACTIN Gene

CACTIN (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene. Diseases associated with CACTIN include renal cell carcinoma. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for CACTIN Gene

  • Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Gene Wiki entry for CACTIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACTIN Gene

Genomics for CACTIN Gene

Regulatory Elements for CACTIN Gene

Promoters for CACTIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CACTIN on UCSC Golden Path with GeneCards custom track

Genomic Location for CACTIN Gene

Chromosome:
19
Start:
3,610,628 bp from pter
End:
3,626,815 bp from pter
Size:
16,188 bases
Orientation:
Minus strand

Genomic View for CACTIN Gene

Genes around CACTIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACTIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACTIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACTIN Gene

Proteins for CACTIN Gene

  • Protein details for CACTIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUQ7-CATIN_HUMAN
    Recommended name:
    Cactin
    Protein Accession:
    Q8WUQ7
    Secondary Accessions:
    • A6NNA9
    • A9UL12
    • O75229
    • Q7LE08
    • Q9BTA6
    • Q9Y5A4

    Protein attributes for CACTIN Gene

    Size:
    758 amino acids
    Molecular mass:
    88702 Da
    Quaternary structure:
    • Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex.
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    SequenceCaution:
    • Sequence=AAC24305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC32903.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD42868.1; Type=Frameshift; Positions=711; Evidence={ECO:0000305}; Sequence=AAH04262.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW69298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CACTIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACTIN Gene

Proteomics data for CACTIN Gene at MOPED

Post-translational modifications for CACTIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CACTIN Gene

Domains & Families for CACTIN Gene

Protein Domains for CACTIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CACTIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUQ7

UniProtKB/Swiss-Prot:

CATIN_HUMAN :
  • Belongs to the CACTIN family.
Family:
  • Belongs to the CACTIN family.
genes like me logo Genes that share domains with CACTIN: view

No data available for Gene Families for CACTIN Gene

Function for CACTIN Gene

Molecular function for CACTIN Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.
genes like me logo Genes that share phenotypes with CACTIN: view

Animal Model Products

miRNA for CACTIN Gene

miRTarBase miRNAs that target CACTIN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CACTIN Gene

Localization for CACTIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACTIN Gene

Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACTIN Gene COMPARTMENTS Subcellular localization image for CACTIN gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CACTIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CACTIN: view

Pathways & Interactions for CACTIN Gene

SuperPathways for CACTIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACTIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001933 negative regulation of protein phosphorylation IMP 20829348
GO:0007275 multicellular organism development IEA --
GO:0032717 negative regulation of interleukin-8 production IDA 20829348
GO:0032720 negative regulation of tumor necrosis factor production IDA 20829348
genes like me logo Genes that share ontologies with CACTIN: view

No data available for Pathways by source and SIGNOR curated interactions for CACTIN Gene

Drugs & Compounds for CACTIN Gene

No Compound Related Data Available

Transcripts for CACTIN Gene

mRNA/cDNA for CACTIN Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACTIN Gene

Cactin, spliceosome C complex subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACTIN Gene

No ASD Table

Relevant External Links for CACTIN Gene

GeneLoc Exon Structure for
CACTIN
ECgene alternative splicing isoforms for
CACTIN

Expression for CACTIN Gene

mRNA expression in normal human tissues for CACTIN Gene

Protein differential expression in normal tissues from HIPED for CACTIN Gene

This gene is overexpressed in CD8 Tcells (18.2), Peripheral blood mononuclear cells (12.1), Testis (7.2), and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACTIN Gene



SOURCE GeneReport for Unigene cluster for CACTIN Gene Hs.128425

genes like me logo Genes that share expression patterns with CACTIN: view

Protein tissue co-expression partners for CACTIN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CACTIN Gene

Orthologs for CACTIN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CACTIN Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CACTIN 35
  • 92.55 (n)
  • 97.12 (a)
CACTIN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cactin 35
  • 83.36 (n)
  • 88.18 (a)
Cactin 16
Cactin 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACTIN 35
  • 98.8 (n)
  • 98.99 (a)
CACTIN 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cactin 35
  • 83.53 (n)
  • 89.02 (a)
cow
(Bos Taurus)
Mammalia CACTIN 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACTIN 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACTIN 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACTIN 35
  • 85.71 (n)
  • 90.07 (a)
CACTIN 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACTIN 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cactin 35
  • 71.66 (n)
  • 86.66 (a)
zebrafish
(Danio rerio)
Actinopterygii cactin 35
  • 76.69 (n)
  • 82.52 (a)
cactin 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006542 35
  • 62.7 (n)
  • 56.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta cactin 35
  • 63.91 (n)
  • 56.8 (a)
cactin 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cacn-1 35
  • 50.5 (n)
  • 46.08 (a)
cacn-1 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03910 35
  • 51.37 (n)
  • 45.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6596 36
  • 54 (a)
OneToOne
Species with no ortholog for CACTIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACTIN Gene

ENSEMBL:
Gene Tree for CACTIN (if available)
TreeFam:
Gene Tree for CACTIN (if available)

Paralogs for CACTIN Gene

No data available for Paralogs for CACTIN Gene

Variants for CACTIN Gene

Sequence variations from dbSNP and Humsavar for CACTIN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1060571 -- 3,623,979(-) TCCAG(A/C)TCCGC reference, missense
rs768962 -- 3,615,166(+) CAAAC(A/G)GCTCC intron-variant
rs768963 -- 3,615,409(+) ACCTC(A/G)CAACC intron-variant
rs768964 -- 3,615,436(+) ATGCC(C/G)AACCC intron-variant
rs768965 -- 3,615,467(+) CACGC(A/G)CTGTG intron-variant

Variation tolerance for CACTIN Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACTIN Gene

HapMap Linkage Disequilibrium report
CACTIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CACTIN Gene

Disorders for CACTIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for CACTIN Gene - From: GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CACTIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACTIN
genes like me logo Genes that share disorders with CACTIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACTIN Gene

Publications for CACTIN Gene

  1. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. (PMID: 20829348) Atzei P. … Moynagh P.N. (J. Biol. Chem. 2010) 2 3 4 67
  2. Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ. (PMID: 21429463) Nazarian J. … Hoffman E.P. (Mar Genomics 2011) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for CACTIN Gene

Sources for CACTIN Gene

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