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Aliases for CACTIN Gene

Aliases for CACTIN Gene

  • Cactin, Spliceosome C Complex Subunit 2 3
  • Functional Spliceosome-Associated Protein C 2 3
  • Renal Carcinoma Antigen NY-REN-24 3 4
  • NY REN 24 Antigen 2 3
  • C19orf29 3 4
  • Chromosome 19 Open Reading Frame 29 2
  • Cactin Homolog (Drosophila) 2
  • NY-REN-24 3
  • Cactin 3
  • FSAPc 3

External Ids for CACTIN Gene

Previous HGNC Symbols for CACTIN Gene

  • C19orf29

Summaries for CACTIN Gene

GeneCards Summary for CACTIN Gene

CACTIN (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CACTIN Gene

  • Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Gene Wiki entry for CACTIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACTIN Gene

Genomics for CACTIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACTIN Gene

Start:
3,610,628 bp from pter
End:
3,626,815 bp from pter
Size:
16,188 bases
Orientation:
Minus strand

Genomic View for CACTIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACTIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACTIN Gene

No data available for Regulatory Elements for CACTIN Gene

Proteins for CACTIN Gene

  • Protein details for CACTIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUQ7-CATIN_HUMAN
    Recommended name:
    Cactin
    Protein Accession:
    Q8WUQ7
    Secondary Accessions:
    • A6NNA9
    • A9UL12
    • O75229
    • Q7LE08
    • Q9BTA6
    • Q9Y5A4

    Protein attributes for CACTIN Gene

    Size:
    758 amino acids
    Molecular mass:
    88702 Da
    Quaternary structure:
    • Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex.
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma
    SequenceCaution:
    • Sequence=AAC24305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC32903.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD42868.1; Type=Frameshift; Positions=711; Evidence={ECO:0000305}; Sequence=AAH04262.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW69298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CACTIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACTIN Gene

Proteomics data for CACTIN Gene at MOPED

Post-translational modifications for CACTIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CACTIN Gene

Domains for CACTIN Gene

Protein Domains for CACTIN Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WUQ7

UniProtKB/Swiss-Prot:

CATIN_HUMAN :
  • Q8WUQ7
Family:
  • Belongs to the CACTIN family.
genes like me logo Genes that share domains with CACTIN: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CACTIN Gene

Function for CACTIN Gene

Molecular function for CACTIN Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for CACTIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20829348
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with CACTIN: view

Phenotypes for CACTIN Gene

GenomeRNAi human phenotypes for CACTIN:
genes like me logo Genes that share phenotypes with CACTIN: view

Animal Model Products

miRNA for CACTIN Gene

miRTarBase miRNAs that target CACTIN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACTIN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CACTIN Gene

Localization for CACTIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACTIN Gene

Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.

Gene Ontology (GO) - Cellular Components for CACTIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with CACTIN: view

No data available for Subcellular locations from COMPARTMENTS for CACTIN Gene

Pathways for CACTIN Gene

SuperPathways for CACTIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACTIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001933 negative regulation of protein phosphorylation IMP 20829348
GO:0007275 multicellular organismal development IEA --
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP 20829348
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 20829348
genes like me logo Genes that share ontologies with CACTIN: view

No data available for Pathways by source for CACTIN Gene

Transcripts for CACTIN Gene

mRNA/cDNA for CACTIN Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACTIN Gene

Cactin, spliceosome C complex subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACTIN

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACTIN Gene

No ASD Table

Relevant External Links for CACTIN Gene

GeneLoc Exon Structure for
CACTIN
ECgene alternative splicing isoforms for
CACTIN

Expression for CACTIN Gene

mRNA expression in normal human tissues for CACTIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CACTIN Gene

This gene is overexpressed in CD8 Tcells (18.2), Peripheral blood mononuclear cells (12.1), Testis (7.2), and NK cells (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACTIN Gene

SOURCE GeneReport for Unigene cluster for CACTIN Gene Hs.128425

genes like me logo Genes that share expressions with CACTIN: view

Expression partners for CACTIN Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CACTIN Gene

Orthologs for CACTIN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CACTIN Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CACTIN 35
  • 92.55 (n)
  • 97.12 (a)
CACTIN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cactin 35
  • 83.36 (n)
  • 88.18 (a)
Cactin 16
Cactin 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACTIN 35
  • 98.8 (n)
  • 98.99 (a)
CACTIN 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cactin 35
  • 83.53 (n)
  • 89.02 (a)
cow
(Bos Taurus)
Mammalia CACTIN 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACTIN 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACTIN 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACTIN 35
  • 85.71 (n)
  • 90.07 (a)
CACTIN 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACTIN 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cactin 35
  • 71.66 (n)
  • 86.66 (a)
zebrafish
(Danio rerio)
Actinopterygii cactin 35
  • 76.69 (n)
  • 82.52 (a)
cactin 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006542 35
  • 62.7 (n)
  • 56.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta cactin 35
  • 63.91 (n)
  • 56.8 (a)
cactin 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cacn-1 35
  • 50.5 (n)
  • 46.08 (a)
cacn-1 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03910 35
  • 51.37 (n)
  • 45.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6596 36
  • 54 (a)
OneToOne
Species with no ortholog for CACTIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACTIN Gene

ENSEMBL:
Gene Tree for CACTIN (if available)
TreeFam:
Gene Tree for CACTIN (if available)

Paralogs for CACTIN Gene

No data available for Paralogs for CACTIN Gene

Variants for CACTIN Gene

Sequence variations from dbSNP and Humsavar for CACTIN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs768962 -- 3,615,166(+) CAAAC(A/G)GCTCC intron-variant
rs768963 -- 3,615,409(+) ACCTC(A/G)CAACC intron-variant
rs768964 -- 3,615,436(+) ATGCC(C/G)AACCC intron-variant
rs768965 -- 3,615,467(+) CACGC(A/G)CTGTG intron-variant
rs1060571 -- 3,623,979(-) TCCAG(A/C)TCCGC missense, reference

Relevant External Links for CACTIN Gene

HapMap Linkage Disequilibrium report
CACTIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CACTIN Gene

Disorders for CACTIN Gene

No disorders were found for CACTIN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CACTIN Gene

Publications for CACTIN Gene

  1. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. (PMID: 20829348) Atzei P. … Moynagh P.N. (J. Biol. Chem. 2010) 2 3 4
  2. Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ. (PMID: 21429463) Nazarian J. … Hoffman E.P. (Mar Genomics 2011) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  5. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4

Products for CACTIN Gene

Sources for CACTIN Gene

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