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CACNG8 Gene

protein-coding   GIFtS: 52
GCID: GC19P054466

Calcium Channel, Voltage-Dependent, Gamma Subunit 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 81 2
Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit2 3
Transmembrane AMPAR Regulatory Protein Gamma-82 3
TARP Gamma-82 3
Voltage-Dependent Calcium Channel Gamma-8 Subunit2
CACNG63

External Ids:    HGNC: 136281   Entrez Gene: 592832   Ensembl: ENSG000001424087   OMIM: 6069005   UniProtKB: Q8WXS53   

Export aliases for CACNG8 gene to outside databases

Previous GC identifers: GC19P055111 GC19P054890 GC19P059142 GC19P059158 GC19P050783


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CACNG8 Gene:
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate
both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse
eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members,
a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation
from a non-AUG (CUG) start codon. (provided by RefSeq, Dec 2010)

GeneCards Summary for CACNG8 Gene:
CACNG8 (calcium channel, voltage-dependent, gamma subunit 8) is a protein-coding gene. Diseases associated with CACNG8 include childhood medulloblastoma, and medulloblastoma. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG4.

UniProtKB/Swiss-Prot: CCG8_HUMAN, Q8WXS5
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
activation, deactivation and desensitization and by mediating their resensitization. Does not show
subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium
channel in an inactivated (closed) state




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CACNG8 gene promoter:
         Max1   RP58   Tal-1   MyoD   CUTL1   IRF-1   E47   GATA-1   Sox9   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCACNG8 promoter sequence
   Search Chromatin IP Primers for CACNG8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACNG8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

CACNG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054466:  view genomic region     (about GC identifiers)

Start:
54,466,290 bp from pter      End:
54,493,469 bp from pter
Size:
27,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCG8_HUMAN, Q8WXS5 (See protein sequence)
Recommended Name: Voltage-dependent calcium channel gamma-8 subunit  
Size: 425 amino acids; 43313 Da
Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as
an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2,
GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity)
Sequence caution: Sequence=AAK15019.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=AAL50049.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9BXT0 Q9BY23

Explore the universe of human proteins at neXtProt for CACNG8: NX_Q8WXS5

Explore proteomics data for CACNG8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CACNG8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114101.4  
    ENSEMBL proteins: 
     ENSP00000270458  
    Reactome Protein details: Q8WXS5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CACN: Calcium channel subunits

    3 InterPro protein domains:
     IPR008372 VDCC_g8su
     IPR008368 VDCC_gsu
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q8WXS5

    ProtoNet protein and cluster: Q8WXS5

    1 Blocks protein domain: IPB006187 Claudin family signature

    UniProtKB/Swiss-Prot: CCG8_HUMAN, Q8WXS5
    Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily


    CACNG8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCG8_HUMAN, Q8WXS5
    Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
    their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
    activation, deactivation and desensitization and by mediating their resensitization. Does not show
    subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium
    channel in an inactivated (closed) state

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005245voltage-gated calcium channel activity NAS11170751
         
    CACNG8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CACNG8:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cacng8):
     growth/size/body  mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    CACNG8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CACNG8: Cacng8tm1Ran Cacng8tm1.1Mwa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CACNG8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CACNG8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CACNG8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CACNG8:
    hsa-mir-652-3p (MIRT039482), hsa-mir-335-5p (MIRT019066), hsa-mir-92b-5p (MIRT037799), hsa-let-7b-5p (MIRT052055), hsa-let-7c-5p (MIRT051755), hsa-let-7d-5p (MIRT051710)

    Block miRNA regulation of human, mouse, rat CACNG8 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CACNG8:
    hsa-miR-877* hsa-miR-571 hsa-miR-1224-3p hsa-miR-129-3p hsa-miR-129*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCG8_HUMAN, Q8WXS5: Membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic
    cell membrane, postsynaptic density (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005891voltage-gated calcium channel complex NAS11170751
    GO:0014069postsynaptic density ISS--
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    CACNG8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CACNG8 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    2TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    Fc-EpsilonRI Pathway0.49
    TCR Signaling0.68
    PDGF Pathway0.39
    ITK and TCR Signaling0.54
    3DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression0.44
    Caspase Cascade0.36
    BMP Pathway0.44
    Calpain Protease Regulates Cellular Mechanics0.31
    nNOS Signaling in Skeletal Muscle0.37
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CACNG8 (see all 37)
        Caspase Cascade
    Fc-GammaR Pathway
    Intracellular Calcium Signaling
    PDGF Pathway
    BMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for CACNG8
        Transcription CREB pathway

    1 BioSystems Pathway for CACNG8
        Arrhythmogenic right ventricular cardiomyopathy

    1 Reactome Pathway for CACNG8
        Trafficking of AMPA receptors


    Selected Kegg Pathways  (Kegg details for CACNG8) (see all 7):
        MAPK signaling pathway
    Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes
    Oxytocin signaling pathway
    Hypertrophic cardiomyopathy (HCM)


    CACNG8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CACNG8
    Interactions:

        Search GeneGlobe Interaction Network for CACNG8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CACNG8 (Q8WXS53 ENSP000002704584) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIA2P422623, ENSP000002644264I2D: score=1 STRING: ENSP00000264426
    CACNA1CENSP000002663764STRING: ENSP00000266376
    CACNA1DENSP000002881394STRING: ENSP00000288139
    CACNA1SENSP000003551924STRING: ENSP00000355192
    CACNA2D1ENSP000003493204STRING: ENSP00000349320
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport NAS11170751
    GO:0007268synaptic transmission TAS--
    GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--

    CACNG8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CACNG8 (CCG8)

    1 HMDB Compound for CACNG8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CACNG8 gene: 
    NM_031895.5  

    Unigene Cluster for CACNG8:

    Calcium channel, voltage-dependent, gamma subunit 8
    Hs.631595  [show with all ESTs]
    Unigene Representative Sequence: NM_031895
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000270458(uc002qcs.2)
    miRNA
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    Additional mRNA sequence: 

    AF234892.1 AF288388.1 AF361354.1 AK055160.1 AK131287.1 

    6 DOTS entries:

    DT.95149460  DT.99950498  DT.95339821  DT.95117414  DT.95365160  DT.95241506 

    4 AceView cDNA sequences:

    NM_031895 AF288388 AF234892 AF361354 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CACNG8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGTCCCC
    CACNG8 Expression
    About this image


    CACNG8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    CACNG8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CACNG8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631595
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CACNG8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacng81 , 5 calcium channel, voltage-dependent, gamma subunit 81, 5 85.08(n)1
    88.33(a)1
      7 (1.98 cM)5
    819051  NM_133190.11  NP_573453.11 
     33906835 
    lizard
    (Anolis carolinensis)
    Reptilia CACNG86
    calcium channel, voltage-dependent, gamma subunit ...
    79(a)
    1 ↔ 1
    GL343329.1(451186-476759)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cacng81 calcium channel, voltage-dependent, gamma subunit 8 69.03(n)
    79.32(a)
      779664  NM_001078749.1  NP_001072217.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145822 Transcribed sequence with weak similarity to protein more 81.16(n)    BI533762.1 


    ENSEMBL Gene Tree for CACNG8 (if available)
    TreeFam Gene Tree for CACNG8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CACNG8 gene
    CACNG42  CACNG72  CACNG52  CACNG22  CACNG32  
    4 SIMAP similar genes for CACNG8 using alignment to 1 protein entry:     CCG8_HUMAN:
    CACNG4    CACNG2    CACNG3    CACNG5

    CACNG8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CACNG8 (see all 568)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161980441,2
    --54464351(+) CTATAC/TGATGA 1 -- us2k10--------
    rs287102681,2
    C,F--54464382(+) CTTCCT/CGGTAC 1 -- us2k1 tfbs33Minor allele frequency- C:0.21WA CSA 122
    rs121509651,2
    C,F,H--54464398(+) AGAGAG/AAGTGG 1 -- us2k1 trp314Minor allele frequency- A:0.07NS EA NA WA 1890
    rs1486124701,2
    --54464565(+) GGAGTA/GCAGGG 1 -- us2k10--------
    rs1420918251,2
    --54464640(+) AGAAAA/GTGCCG 1 -- us2k10--------
    rs58285601,2
    C--54464718(+) TGTGGG/-GGGGG 1 -- us2k1 tfbs3 trp31Minor allele frequency- -:0.00NA 2
    rs1909448581,2
    --54464737(+) CGGGGG/TGGGAA 1 -- us2k10--------
    rs1834502151,2
    --54464740(+) GGTGGA/GAAGAT 1 -- us2k10--------
    rs1467772411,2
    C--54464874(+) ATGGC-/GGGGGG 1 -- us2k10--------
    rs614437681,2
    C--54464883(+) GGGGG-/TGCAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CACNG8 (54466290 - 54493469 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CACNG8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv662e199CNV Deletion23128226
    nsv820406CNV Deletion20802225
    esv2718812CNV Deletion23290073
    nsv912391CNV Loss21882294
    esv21442CNV Loss19812545
    nsv828624CNV Loss20364138
    nsv833876CNV Loss17160897
    nsv833877CNV Loss17160897
    dgv4000n71CNV Loss21882294
    nsv458782CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606900    OMIM disorders: --

    5 diseases for CACNG8:    
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    childhood medulloblastoma    medulloblastoma    hypertrophic cardiomyopathy    dilated cardiomyopathy
    neuronitis


    CACNG8 for disorders           About GeneDecksing


    Export disorders for CACNG8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CACNG8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CACNG8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. (PubMed id 11170751)1, 2, 3, 9 Burgess D.L.... Noebels J.L. (Genomics 2001)
    2. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PubMed id 11738816)1, 2 Chu P.-J.... Best P.M. (Gene 2001)
    3. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PubMed id 21172611)2 Kato A.S.... Bredt D.S. (Neuron 2010)
    4. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PubMed id 20805473)2 Shi Y....Nicoll R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. (PubMed id 18304745)1 Sager C....Hollmann M. (Neuroscience 2009)
    6. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. (PubMed id 18311135)1 Correia S.S....Esteban J.A. (Nat. Neurosci. 2008)
    7. Calcium channel gamma subunits: a functionally diverse protein family. (PubMed id 17652770)1 Chen R.S....Best P.M. (Cell Biochem. Biophys. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59283 HGNC: 13628 AceView: CACNG8 Ensembl:ENSG00000142408 euGenes: HUgn59283
    ECgene: CACNG8 Kegg: 59283 H-InvDB: CACNG8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CACNG8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CACNG8 gene:
    Search GeneIP for patents involving CACNG8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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