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Aliases for CACNG7 Gene

Aliases for CACNG7 Gene

  • Calcium Channel, Voltage-Dependent, Gamma Subunit 7 2 3
  • Neuronal Voltage-Gated Calcium Channel Gamma-7 Subunit 4
  • Transmembrane AMPAR Regulatory Protein Gamma-7 4
  • TARP Gamma-7 4

External Ids for CACNG7 Gene

Previous GeneCards Identifiers for CACNG7 Gene

  • GC19P055061
  • GC19P054840
  • GC19P059093
  • GC19P059107
  • GC19P054412
  • GC19P050735

Summaries for CACNG7 Gene

Entrez Gene Summary for CACNG7 Gene

  • The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

GeneCards Summary for CACNG7 Gene

CACNG7 (Calcium Channel, Voltage-Dependent, Gamma Subunit 7) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG2.

UniProtKB/Swiss-Prot for CACNG7 Gene

  • Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNG7 Gene

Genomics for CACNG7 Gene

Regulatory Elements for CACNG7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACNG7 Gene

Chromosome:
19
Start:
53,909,335 bp from pter
End:
53,943,941 bp from pter
Size:
34,607 bases
Orientation:
Plus strand

Genomic View for CACNG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNG7 Gene

Proteins for CACNG7 Gene

  • Protein details for CACNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62955-CCG7_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-7 subunit
    Protein Accession:
    P62955
    Secondary Accessions:
    • Q52LL8
    • Q8VBX3
    • Q8WXS6
    • Q9BXT1

    Protein attributes for CACNG7 Gene

    Size:
    275 amino acids
    Molecular mass:
    31003 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8

neXtProt entry for CACNG7 Gene

Proteomics data for CACNG7 Gene at MOPED

Post-translational modifications for CACNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACNG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CACNG7 Gene

Domains & Families for CACNG7 Gene

Gene Families for CACNG7 Gene

Protein Domains for CACNG7 Gene

Suggested Antigen Peptide Sequences for CACNG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62955

UniProtKB/Swiss-Prot:

CCG7_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with CACNG7: view

Function for CACNG7 Gene

Molecular function for CACNG7 Gene

UniProtKB/Swiss-Prot Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.

Gene Ontology (GO) - Molecular Function for CACNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity NAS 11170751
GO:0016247 channel regulator activity IBA --
genes like me logo Genes that share ontologies with CACNG7: view
genes like me logo Genes that share phenotypes with CACNG7: view

Animal Models for CACNG7 Gene

MGI Knock Outs for CACNG7:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CACNG7 Gene

Localization for CACNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNG7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNG7 Gene COMPARTMENTS Subcellular localization image for CACNG7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CACNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005891 voltage-gated calcium channel complex NAS 11170751
GO:0016021 integral component of membrane --
GO:0032281 AMPA glutamate receptor complex ISS --
genes like me logo Genes that share ontologies with CACNG7: view

Pathways & Interactions for CACNG7 Gene

genes like me logo Genes that share pathways with CACNG7: view

Interacting Proteins for CACNG7 Gene

Gene Ontology (GO) - Biological Process for CACNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport NAS 11170751
GO:0019226 transmission of nerve impulse IBA --
GO:0070588 calcium ion transmembrane transport IBA --
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA 21172611
genes like me logo Genes that share ontologies with CACNG7: view

No data available for SIGNOR curated interactions for CACNG7 Gene

Drugs & Compounds for CACNG7 Gene

(2) Drugs for CACNG7 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aniracetam Experimental Pharma Positive, Allosteric regulator Nootropic drug for senile dementia 0
Calcium Nutra 0
genes like me logo Genes that share compounds with CACNG7: view

Transcripts for CACNG7 Gene

mRNA/cDNA for CACNG7 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNG7 Gene

Calcium channel, voltage-dependent, gamma subunit 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNG7 Gene

No ASD Table

Relevant External Links for CACNG7 Gene

GeneLoc Exon Structure for
CACNG7
ECgene alternative splicing isoforms for
CACNG7

Expression for CACNG7 Gene

mRNA expression in normal human tissues for CACNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNG7 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Frontal Cortex (BA9) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Amygdala (x4.7), Brain - Hippocampus (x4.7), and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for CACNG7 Gene

This gene is overexpressed in Frontal cortex (53.7) and Retina (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CACNG7 Gene



SOURCE GeneReport for Unigene cluster for CACNG7 Gene Hs.631597

mRNA Expression by UniProt/SwissProt for CACNG7 Gene

P62955-CCG7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CACNG7: view

Protein tissue co-expression partners for CACNG7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CACNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACNG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNG7 35
  • 93.7 (n)
  • 100 (a)
CACNG7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611509 35
  • 93.09 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cacng7 35
  • 90.91 (n)
  • 100 (a)
Cacng7 16
Cacng7 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNG7 35
  • 99.88 (n)
  • 100 (a)
CACNG7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacng7 35
  • 90.55 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNG7 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNG7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNG7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacng7 35
  • 79.15 (n)
  • 93.09 (a)
zebrafish
(Danio rerio)
Actinopterygii cacng7b 35
  • 72.5 (n)
  • 84.05 (a)
cacng7a 36
  • 67 (a)
OneToMany
cacng7b 36
  • 60 (a)
OneToMany
Species with no ortholog for CACNG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACNG7 Gene

ENSEMBL:
Gene Tree for CACNG7 (if available)
TreeFam:
Gene Tree for CACNG7 (if available)

Paralogs for CACNG7 Gene

Paralogs for CACNG7 Gene

(1) SIMAP similar genes for CACNG7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CACNG7: view

Variants for CACNG7 Gene

Sequence variations from dbSNP and Humsavar for CACNG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs160116 -- 53,923,449(-) ACCAG(A/G)CCTGG intron-variant
rs217541 -- 53,940,612(-) TAGCC(A/G)TGGTG intron-variant
rs307913 -- 53,939,797(-) ttcca(C/T)tccta intron-variant
rs307914 -- 53,938,536(-) ctgag(C/T)agtta intron-variant
rs307915 -- 53,938,427(-) CGGTA(C/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNG7 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833876 CNV Loss 17160897
nsv2541 CNV Loss 18451855
esv24802 CNV Gain+Loss 19812545
nsv821044 CNV Deletion 20802225
esv2669842 CNV Deletion 23128226
esv1776456 CNV Insertion 17803354
esv1132464 CNV Deletion 17803354
esv1297128 CNV Deletion 17803354
esv1328421 CNV Deletion 17803354
esv1077595 CNV Deletion 17803354
esv1583311 CNV Deletion 17803354
esv1716904 CNV Deletion 17803354
nsv912390 CNV Gain 21882294

Variation tolerance for CACNG7 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACNG7 Gene

HapMap Linkage Disequilibrium report
CACNG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNG7 Gene

Disorders for CACNG7 Gene

Relevant External Links for CACNG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACNG7
genes like me logo Genes that share disorders with CACNG7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CACNG7 Gene

Publications for CACNG7 Gene

  1. Changes in the proteome of human bronchial epithelial cells following stimulation with leucotriene E4 and transforming growth factor-beta1. (PMID: 19144047) Altraja S. … Altraja A. (Respirology 2009) 23 67
  2. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PMID: 11927536) Moss F.J. … Dolphin A.C. (EMBO J. 2002) 23 67
  3. A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. (PMID: 11170751) Burgess D.L. … Noebels J.L. (Genomics 2001) 2 67
  4. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PMID: 21172611) Kato A.S. … Bredt D.S. (Neuron 2010) 67
  5. Calcium channel gamma subunits: a functionally diverse protein family. (PMID: 17652770) Chen R.S. … Best P.M. (Cell Biochem. Biophys. 2007) 67

Products for CACNG7 Gene

Sources for CACNG7 Gene

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