Aliases for CACNG7 Gene
External Ids for CACNG7 Gene
Previous GeneCards Identifiers for CACNG7 Gene
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG7 Gene
CACNG7 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG2.
UniProtKB/Swiss-Prot for CACNG7 Gene
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.