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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CACNG7 Gene

protein-coding   GIFtS: 50
GCID: GC19P054412

calcium channel, voltage-dependent, gamma subunit 7

  Search for CACNG7
in our new
 Human Malady Compendium 
Biological research products
for CACNG7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 71 2
Neuronal Voltage-Gated Calcium Channel Gamma-7 Subunit2 3
Transmembrane AMPAR Regulatory Protein Gamma-72 3
TARP Gamma-72 3
Voltage-Dependent Calcium Channel Gamma-7 Subunit2

External Ids:    HGNC: 136261   Entrez Gene: 592842   Ensembl: ENSG000001056057   OMIM: 6068995   UniProtKB: P629553   

Export aliases for CACNG7 gene to outside databases

Previous GC identifers: GC19P055061 GC19P054840 GC19P059093 GC19P059107 GC19P050735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CACNG7:
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate
both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member
protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and
a calcium channel gamma subunit. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: CCG7_HUMAN, P62955
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA
receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an
inactivated (closed) state




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CACNG7 gene promoter:
         AhR   POU2F1   AML1a   POU2F1a   NRSF form 1   HSF1short   NRSF form 2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCACNG7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CACNG7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

CACNG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054412:  view genomic region     (about GC identifiers)

Start:
54,412,589 bp from pter      End:
54,447,195 bp from pter
Size:
34,607 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCG7_HUMAN, P62955 (See protein sequence)
Recommended Name: Voltage-dependent calcium channel gamma-7 subunit  
Size: 275 amino acids; 31003 Da
Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an
auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,
CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q52LL8 Q8VBX3 Q8WXS6 Q9BXT1

Explore the universe of human proteins at neXtProt for CACNG7: NX_P62955

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62955

  • CACNG7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_114102.2  
    ENSEMBL proteins: 
     ENSP00000375647   ENSP00000222212   ENSP00000375646  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005891voltage-gated calcium channel complex NAS11170751
    GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ISS--


    CACNG7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CACNG7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008368 VDCC_gsu
     IPR008371 VDCC_g7su

    Graphical View of Domain Structure for InterPro Entry P62955

    ProtoNet protein and cluster: P62955

    UniProtKB/Swiss-Prot: CCG7_HUMAN, P62955
    Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CCG7_HUMAN, P62955
    Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
    their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
    activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA
    receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an
    inactivated (closed) state

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNG7
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    hsa-miR-142-5p hsa-miR-3616-5p hsa-miR-1224-3p hsa-miR-488 hsa-miR-639 hsa-miR-4260 hsa-miR-766 hsa-miR-583
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG7

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005245voltage-gated calcium channel activity NAS11170751


    CACNG7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CACNG7:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Cacng7tm1Mwa for CACNG7
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cacng7):
     behavior/neurological  growth/size  nervous system  normal 

    CACNG7 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression1.00
    Caspase Cascade0.24
    BMP Pathway0.44
    Calpain Protease Regulates Cellular Mechanics0.22
    nNOS Signaling in Skeletal Muscle0.37
    2PKC-Theta Pathway
    PKC-Theta Pathway1.00
    Fc-EpsilonRI Pathway0.42
    TCR Signaling0.68
    PDGF Pathway0.35
    ITK and TCR Signaling0.54
    3Sweet Taste Signaling
    Sweet Taste Signaling1.00
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    PKA Signaling0.56
    cAMP Pathway0.77
    5NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy1.00
    IGF1R Signaling0.37
    Signaling Involved in Cardiac Hypertrophy0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CACNG7
        Transcription CREB pathway

    5/37 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNG7 (see all 37)
        Caspase Cascade
    Fc-GammaR Pathway
    Intracellular Calcium Signaling
    PDGF Pathway
    BMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for CACNG7
        Transcription CREB pathway

    1 BioSystems Pathway for CACNG7 
        Arrhythmogenic right ventricular cardiomyopathy


    5         Kegg Pathways  (Kegg details for CACNG7):
        MAPK signaling pathway
    Cardiac muscle contraction
    Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy


    CACNG7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for CACNG7 (ENSP000002222124) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CENSP000002663764STRING: ENSP00000266376
    CACNA1DENSP000002881394STRING: ENSP00000288139
    CACNA2D1ENSP000003493204STRING: ENSP00000349320
    CACNB3ENSP000003010504STRING: ENSP00000301050
    CACNG3ENSP000000052844STRING: ENSP00000005284
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport NAS11170751
    GO:0051925regulation of calcium ion transport via voltage-gated calcium channel activity ----
    GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--


    CACNG7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CACNG7

    1 HMDB Compound for CACNG7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CACNG7 / CCG7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CACNG7 gene: 
    NM_031896.4  

    Unigene Cluster for CACNG7:

    Calcium channel, voltage-dependent, gamma subunit 7
    Hs.631597  [show with all ESTs]
    Unigene Representative Sequence: NM_031896
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391767(uc002qcr.2) ENST00000468076 ENST00000222212(uc010era.2)
    ENST00000391766

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    hsa-miR-142-5p hsa-miR-3616-5p hsa-miR-1224-3p hsa-miR-488 hsa-miR-639 hsa-miR-4260 hsa-miR-766 hsa-miR-583
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    Additional cDNA sequence: 

    AF288387.1 AF361353.1 AF458897.1 BC069332.1 BC093869.1 BC113503.1 

    4 DOTS entries:

    DT.97823965  DT.432923  DT.91749500  DT.121493294 

    16 AceView cDNA sequences:

    NM_031896 AF458897 CR596328 AF288387 AF361353 CF454373 AI650714 BC069332 
    H12168 AL537399 BU739889 H11643 BE855530 AL537398 H30627 BF364668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CACNG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACAGGCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CACNG7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CACNG7

    SOURCE GeneReport for Unigene cluster: Hs.631597

    UniProtKB/Swiss-Prot: CCG7_HUMAN, P62955
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CACNG7 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CACNG76
    --
    90(a)
    1 ↔ 1
    GL343329.1(516840-542407)
    zebrafish
    (Danio rerio)
    Actinopterygii cacng7b1 calcium channel, voltage-dependent, gamma subunit 7b 72.5(n)
    84.05(a)
      100003278  XM_001342843.2  XP_001342879.2 


    ENSEMBL Gene Tree for CACNG7 (if available)
    TreeFam Gene Tree for CACNG7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CACNG7 gene
    CACNG42  CACNG52  CACNG22  CACNG82  CACNG32  
    1 SIMAP similar gene for CACNG7 using alignment to 1 protein entry:     CCG7_HUMAN:
    CACNG5

    CACNG7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/847 NCBI SNPs in CACNG7 are shown (see all 847    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38102481,2
    C,F,--54414037(-) TTCATC/GTCTGT 1 -- us2k18Minor allele frequency- G:0.18EA NA WA CSA 1750
    rs780856961,2
    F,--54414242(+) TAGTTG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1482267721,2
    --54414250(+) AGGATA/GAGAGA 1 -- us2k10--------
    rs38444541,2
    C,F,A,H,--54414255(+) GAGAGA/TCCGTT 1 -- us2k1 tfbs312Minor allele frequency- T:0.30NA NS EA WA CSA 824
    rs1415086161,2
    --54414270(+) GACTGC/GGGTGC 1 -- us2k10--------
    rs1488893891,2
    C,--54414294(+) TGGAT-/TGG   
      TGGTGG
    TGGTG
    1 -- us2k10--------
    rs789281671,2
    C,--54414347(+) ATGGAG/TTCTCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1837608611,2
    --54414390(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs38528931,2
    C,F,A,H,--54414450(+) GAGTAT/GCTGGG 1 -- us2k12Minor allele frequency- G:0.37NA CSA 8
    rs38528941,2
    C,F,A,H,--54414465(+) TAGGTG/ATGAGC 1 -- us2k13Minor allele frequency- A:0.21NA CSA EA 128

    HapMap Linkage Disequilibrium report for CACNG7 (54412589 - 54447195 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CACNG7
         2 CNVs: 73418 5115
         4 Indels: 26331 26333 26334 26332

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CACNG7 for disorders           About MalaCards

    CACNG7 for disorders           About GeneDecksing

    OMIM gene information: 606899    OMIM disorders: --


    Export disorders for CACNG7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CACNG7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CACNG7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. (PubMed id 11170751)1, 2, 3 Burgess D.L.... Noebels J.L. (2001)
    2. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PubMed id 11927536)1, 2, 9 Moss F.J.... Dolphin A.C. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PubMed id 11738816)1, 2 Chu P.-J.... Best P.M. (2001)
    5. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PubMed id 21172611)2 Kato A.S.... Bredt D.S. (2010)
    6. Calcium channel gamma subunits: a functionally divers e protein family. (PubMed id 17652770)1 Chen R.S....Best P.M. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Changes in the proteome of human bronchial epithelial cells following stimulation with leucotriene E4 and transforming growth factor-beta1. (PubMed id 19144047)9 Altraja S....Altraja A. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59284 HGNC: 13626 AceView: CACNG7 Ensembl:ENSG00000105605 euGenes: HUgn59284
    ECgene: CACNG7 Kegg: 59284 H-InvDB: CACNG7

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CACNG7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CACNG7 gene:
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