CACNG5 Gene

Aliases
for CACNG5 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M063533 GC17M066599 GC17P065290 GC17P065423 GC17P062303 GC17P060262

Summaries
for CACNG5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CACNG5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NC_018928.2  NT_010783.16  

SwitchGear Promoter luciferase reporter plasmid: CACNG5 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACNG5

CACNG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P064873:  view genomic region     (about GC identifiers)

Proteins
for CACNG5 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CACNG5: NX_Q9UF02

Explore proteomics data for CACNG5 at MOPED

Post-translational modifications: 

CACNG5 Human Recombinant Protein Products:

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	antibodies-online peptides for CACNG5

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Domains /
Families
for CACNG5 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UF02

Find genes that share domains with CACNG5           About GenesLikeMe

Function
for CACNG5 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for CACNG5

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CACNG5

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG5

Localization
for CACNG5 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	4
plasma membrane	4
extracellular	2

About this image

Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for CACNG5 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CACNG5 About   (see all 22)   See pathways by source

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	SuperPath	Contained pathways About
1	Hypertrophic cardiomyopathy (HCM)	Hypertrophic cardiomyopathy (HCM) 0.75 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.54 Dilated cardiomyopathy 0.75 Arrhythmogenic right ventricular cardiomyopathy 0.54
2	TCR Signaling (Qiagen)	TCR Signaling 0.68 Fc-EpsilonRI Pathway 0.49 PKC-Theta Pathway 0.68 PDGF Pathway 0.39 ITK and TCR Signaling 0.54
3	DREAM Repression and Dynorphin Expression	DREAM Repression and Dynorphin Expression 0.44 Caspase Cascade 0.36 BMP Pathway 0.44 Calpain Protease Regulates Cellular Mechanics 0.31 nNOS Signaling in Skeletal Muscle 0.37
4	Sweet Taste Signaling	Sweet Taste Signaling 0.72 Cellular Effects of Sildenafil 0.46 Melatonin Signaling 0.72
5	Activation of cAMP-Dependent PKA	Activation of cAMP-Dependent PKA 0.77 PKA Signaling 0.56 cAMP Pathway 0.77

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CACNG5

	Caspase Cascade
	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	PDGF Pathway
	BMP Pathway

1 GeneGo (Thomson Reuters) Pathway for CACNG5

Transcription CREB pathway

1 BioSystems Pathway for CACNG5

Arrhythmogenic right ventricular cardiomyopathy

Selected Kegg Pathways  (Kegg details for CACNG5)

	MAPK signaling pathway
	Cardiac muscle contraction
	Adrenergic signaling in cardiomyocytes
	Oxytocin signaling pathway
	Hypertrophic cardiomyopathy (HCM)

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for CACNG5 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CACNG5 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CACNG5 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CACNG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TACAGGCCCC

About this image

Brain (Nervous System)    fully expand to see all 9 entries
Thalamus
Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Myoblasts Hyoid Arch Muscles
Neurons
GABAergic Amacrine Cells Inner Nuclear Layer
Eye (Sensory Organs)
GABAergic Amacrine Cells Inner Nuclear Layer

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		QuantiFast Probe-based Assays in human, mouse, rat CACNG5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG5

Orthologs
for CACNG5 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CACNG5 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CACNG5 gene

CACNG4²  CACNG7²  CACNG2²  CACNG8²  CACNG3²  

3 SIMAP similar genes for CACNG5 using alignment to 1 protein entry:     CCG5_HUMAN:

CACNG7    CACNG4    CACNG8

Find genes that share paralogs with CACNG5           About GenesLikeMe

Genomic Variants
for CACNG5 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CACNG5 (see all 276)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1147724491,2	F	--	64871431(+)	TTTCAT/CTTCTC	1	--	us2k1		1		WA	118
rs1914289601,2		--	64871543(+)	AGCCAA/GTATAT	1	--	us2k1		0	--	--	--	--
rs1507727361,2		--	64871625(+)	GCCAGC/TGTGCA	1	--	us2k1		0	--	--	--	--
rs1154728311,2	F	--	64871677(+)	CTCTCC/TTCCTA	1	--	us2k1		1		WA	118
rs37602651,2	C,F,A,H	--	64871721(-)	AAATGG/AACAGA	1	--	us2k1		26		EA NS NA WA CSA	3961
rs1146439561,2	F	--	64871863(+)	CCCAAA/GCATCA	1	--	us2k1		1		WA	118
rs728433661,2	C,F	--	64871868(+)	ACATCA/GCTAAC	1	--	us2k1		2		WA NA	238
rs98900011,2	C,F	--	64871902(+)	TTGCAA/GTATTG	1	--	us2k1		2		WA	120
rs1843286291,2		--	64871906(+)	AATATA/TGCAAG	1	--	us2k1		0	--	--	--	--
rs1897408891,2		--	64871930(+)	ATGCCA/GACAGG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CACNG5 (64831235 - 64881603 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CACNG5:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv833521	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CACNG5

DNA2.0 Custom Variant and Variant Library Synthesis for CACNG5

Disorders / Diseases
for CACNG5 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CACNG5 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PubMed id 10613843)^{1, 2, 3} Burgess D.L.... Noebels J.L. (Genome Res. 1999)
2. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. (PubMed id 21057379)^{1, 4} Curtis D....Gurling H.M. (Psychiatr. Genet. 2011)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PubMed id 11927536)^{1, 2} Moss F.J.... Dolphin A.C. (EMBO J. 2002)
5. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PubMed id 11738816)^{1, 2} Chu P.-J.... Best P.M. (Gene 2001)
6. Calcium channel gamma subunits: a functionally diverse protein family. (PubMed id 17652770)¹ Chen R.S....Best P.M. (Cell Biochem. Biophys. 2007)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
9. A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. (PubMed id 11170751)¹ Burgess D.L.... Noebels J.L. (Genomics 2001)

External Searches for CACNG5 gene

Genome Databases showing CACNG5 gene

Other Databases showing CACNG5 gene

Specialized Databases showing CACNG5 gene

Products
for CACNG5 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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