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CACNG5 Gene(Protein Coding)

Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5

GCID:
GC17P066835
GIFtS:
55
Genes Participants
UDN Logo

Aliases for CACNG5 Gene

Aliases for CACNG5 Gene

  • Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5 2 3 5
  • Neuronal Voltage-Gated Calcium Channel Gamma-5 Subunit 4
  • Calcium Channel, Voltage-Dependent, Gamma Subunit 5 2
  • Transmembrane AMPAR Regulatory Protein Gamma-5 4
  • TARP Gamma-5 4

External Ids for CACNG5 Gene

Previous GeneCards Identifiers for CACNG5 Gene

  • GC17M063533
  • GC17M066599
  • GC17P065290
  • GC17P065423
  • GC17P062303
  • GC17P064873
  • GC17P060262

Summaries for CACNG5 Gene

Entrez Gene Summary for CACNG5 Gene

  • The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

GeneCards Summary for CACNG5 Gene

CACNG5 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5) is a Protein Coding gene. Diseases associated with CACNG5 include Schizophrenia. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and ion transmembrane transporter activity. An important paralog of this gene is CACNG7.

UniProtKB/Swiss-Prot for CACNG5 Gene

  • Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNG5 Gene

Genomics for CACNG5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CACNG5 Gene

Enhancers for CACNG5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G066949 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +117.1 117093 5.5 HDGF PKNOX1 FOXA2 MLX ZNF133 ARID4B SIN3A YBX1 FEZF1 ZBTB7B CACNG4 CACNG5 GC17P066938
GH17G066957 1.2 ENCODE dbSUPER 10.3 +123.0 123022 1.2 ELF3 FOXA2 ZFP64 ARID4B ZNF48 ZBTB7B SLC30A9 CREM MIXL1 ZBTB11 NOL11 CACNG5 CACNG4 GC17P066938
GH17G066943 1.1 ENCODE dbSUPER 10.8 +109.2 109183 1.8 HDGF PKNOX1 NFIB BMI1 YBX1 RAD21 ELK1 SCRT2 ZNF207 FOS CACNG4 CACNG5 MIR634 GC17P066938
GH17G066906 1.1 Ensembl ENCODE 10.5 +71.7 71651 0.3 PKNOX1 CBX3 NFIB ZNF2 RAD21 YY1 ZNF143 RELB CREM ZNF654 CACNG5 RNA5SP446 GC17P066938
GH17G066776 1 ENCODE 10.8 -57.1 -57053 3.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF48 ZNF263 SP3 SP5 NFYC CACNG4 CACNG5 GC17P066788 PIR44901
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CACNG5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CACNG5 gene promoter:

Genomic Location for CACNG5 Gene

Chromosome:
17
Start:
66,835,117 bp from pter
End:
66,887,296 bp from pter
Size:
52,180 bases
Orientation:
Plus strand

Genomic View for CACNG5 Gene

Genes around CACNG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACNG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACNG5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CACNG5 Gene

Proteins for CACNG5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CACNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF02-CCG5_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-5 subunit
    Protein Accession:
    Q9UF02
    Secondary Accessions:
    • A8K2A6
    • Q547R3
    • Q8WXS7
    • Q9UHM3

    Protein attributes for CACNG5 Gene

    Size:
    275 amino acids
    Molecular mass:
    30903 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).

neXtProt entry for CACNG5 Gene

Protein Expression for CACNG5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CACNG5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACNG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNG5 Gene

Domains & Families for CACNG5 Gene

Gene Families for CACNG5 Gene

HGNC:

Protein Domains for CACNG5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CACNG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UF02

UniProtKB/Swiss-Prot:

CCG5_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with CACNG5: view

Function for CACNG5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CACNG5 Gene

GENATLAS Biochemistry:
calcium channel,voltage-dependent,gamma subunit 5
UniProtKB/Swiss-Prot Function:
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Gene Ontology (GO) - Molecular Function for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity TAS 10613843
GO:0005262 calcium channel activity IEA --
GO:0015075 ion transmembrane transporter activity TAS 10613843
GO:0016247 channel regulator activity IBA --
genes like me logo Genes that share ontologies with CACNG5: view
genes like me logo Genes that share phenotypes with CACNG5: view

Animal Model Products

miRNA for CACNG5 Gene

miRTarBase miRNAs that target CACNG5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CACNG5 Gene

Localization for CACNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNG5 Gene

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CACNG5 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CACNG5: view

Pathways & Interactions for CACNG5 Gene

genes like me logo Genes that share pathways with CACNG5: view

Gene Ontology (GO) - Biological Process for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10613843
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0019226 transmission of nerve impulse IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CACNG5: view

No data available for SIGNOR curated interactions for CACNG5 Gene

Drugs & Compounds for CACNG5 Gene

Products:

  1. Drug

(2) Drugs for CACNG5 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aniracetam Experimental Pharma Positive, Allosteric regulator Nootropic drug for senile dementia 0
calcium Nutra 0

(1) ApexBio Compounds for CACNG5 Gene

Compound Action Cas Number
Aniracetam Nootropic drug for senile dementia 72432-10-1
genes like me logo Genes that share compounds with CACNG5: view

Transcripts for CACNG5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CACNG5 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNG5 Gene

Calcium channel, voltage-dependent, gamma subunit 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNG5 Gene

No ASD Table

Relevant External Links for CACNG5 Gene

GeneLoc Exon Structure for
CACNG5
ECgene alternative splicing isoforms for
CACNG5

Expression for CACNG5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CACNG5 Gene

mRNA expression in normal human tissues for CACNG5 Gene
mRNA expression by BioGPS for CACNG5 GenemRNA expression by GTEx for CACNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNG5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Nucleus accumbens (basal ganglia) (x4.7), Brain - Putamen (basal ganglia) (x4.6), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for CACNG5 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CACNG5 Gene



Protein tissue co-expression partners for CACNG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CACNG5 Gene:

CACNG5

SOURCE GeneReport for Unigene cluster for CACNG5 Gene:

Hs.278907

Evidence on tissue expression from TISSUES for CACNG5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CACNG5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CACNG5 Gene

Orthologs for CACNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACNG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CACNG5 34 35
  • 99.88 (n)
dog
(Canis familiaris)
 Mammalia CACNG5 34 35
  • 92.24 (n)
mouse
(Mus musculus)
 Mammalia Cacng5 34 16 35
  • 89.45 (n)
rat
(Rattus norvegicus)
 Mammalia Cacng5 34
  • 89.45 (n)
cow
(Bos Taurus)
 Mammalia CACNG5 34 35
  • 88 (n)
chicken
(Gallus gallus)
 Aves -- 35
  • 92 (a)
 OneToMany
-- 35
  • 92 (a)
 OneToMany
LOC100859614 34
  • 83.15 (n)
lizard
(Anolis carolinensis)
 Reptilia CACNG5 35
  • 83 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii cacng5b 35
  • 90 (a)
 OneToMany
cacng5a 35
  • 86 (a)
 OneToMany
LOC100331116 34
  • 80.48 (n)
Species where no ortholog for CACNG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACNG5 Gene

ENSEMBL:
Gene Tree for CACNG5 (if available)
TreeFam:
Gene Tree for CACNG5 (if available)

Paralogs for CACNG5 Gene

Paralogs for CACNG5 Gene

(3) SIMAP similar genes for CACNG5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CACNG5: view

Variants for CACNG5 Gene

Sequence variations from dbSNP and Humsavar for CACNG5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000222477 -- 66,885,524(+) CAGCA(A/G)CTCCC downstream-variant-500B
rs1000437405 -- 66,876,966(+) GTCTG(G/T)CACAA upstream-variant-2KB
rs1000558802 -- 66,881,955(+) ATGGA(C/T)TCGGG intron-variant
rs1001829432 -- 66,878,304(+) TTCTT(A/G)GTAGG intron-variant
rs1002327 -- 66,878,497(-) GTCTG(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNG5 Gene

Variant ID Type Subtype PubMed ID
nsv1120054 OTHER inversion 24896259
nsv833521 CNV loss 17160897

Variation tolerance for CACNG5 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACNG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CACNG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNG5 Gene

Disorders for CACNG5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CACNG5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CACNG5

Genetic Association Database (GAD)
CACNG5
Human Genome Epidemiology (HuGE) Navigator
CACNG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACNG5
genes like me logo Genes that share disorders with CACNG5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACNG5 Gene

Publications for CACNG5 Gene

  1. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PMID: 10613843) Burgess D.L. … Noebels J.L. (Genome Res. 1999) 2 3 4 64
  2. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. (PMID: 21057379) Curtis D. … Gurling H.M. (Psychiatr. Genet. 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PMID: 11927536) Moss F.J. … Dolphin A.C. (EMBO J. 2002) 3 4 64
  5. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PMID: 11738816) Chu P.-J. … Best P.M. (Gene 2001) 3 4 64

Products for CACNG5 Gene

Sources for CACNG5 Gene

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