Aliases for CACNG5 Gene
External Ids for CACNG5 Gene
Previous GeneCards Identifiers for CACNG5 Gene
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG5 Gene
CACNG5 (Calcium Channel, Voltage-Dependent, Gamma Subunit 5) is a Protein Coding gene. Diseases associated with CACNG5 include arrhythmogenic right ventricular cardiomyopathy and bipolar disorder. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and ion transmembrane transporter activity. An important paralog of this gene is CACNG2.
UniProtKB/Swiss-Prot for CACNG5 Gene
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).