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Aliases for CACNG5 Gene

Aliases for CACNG5 Gene

  • Calcium Channel, Voltage-Dependent, Gamma Subunit 5 2 3
  • Neuronal Voltage-Gated Calcium Channel Gamma-5 Subunit 4
  • Transmembrane AMPAR Regulatory Protein Gamma-5 4
  • TARP Gamma-5 4

External Ids for CACNG5 Gene

Previous GeneCards Identifiers for CACNG5 Gene

  • GC17M063533
  • GC17M066599
  • GC17P065290
  • GC17P065423
  • GC17P062303
  • GC17P064873
  • GC17P060262

Summaries for CACNG5 Gene

Entrez Gene Summary for CACNG5 Gene

  • The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

GeneCards Summary for CACNG5 Gene

CACNG5 (Calcium Channel, Voltage-Dependent, Gamma Subunit 5) is a Protein Coding gene. Diseases associated with CACNG5 include arrhythmogenic right ventricular cardiomyopathy and bipolar disorder. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and ion transmembrane transporter activity. An important paralog of this gene is CACNG2.

UniProtKB/Swiss-Prot for CACNG5 Gene

  • Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNG5 Gene

Genomics for CACNG5 Gene

Regulatory Elements for CACNG5 Gene

Genomic Location for CACNG5 Gene

Start:
66,835,117 bp from pter
End:
66,885,486 bp from pter
Size:
50,370 bases
Orientation:
Plus strand

Genomic View for CACNG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNG5 Gene

Proteins for CACNG5 Gene

  • Protein details for CACNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF02-CCG5_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-5 subunit
    Protein Accession:
    Q9UF02
    Secondary Accessions:
    • A8K2A6
    • Q547R3
    • Q8WXS7
    • Q9UHM3

    Protein attributes for CACNG5 Gene

    Size:
    275 amino acids
    Molecular mass:
    30903 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).

neXtProt entry for CACNG5 Gene

Proteomics data for CACNG5 Gene at MOPED

Post-translational modifications for CACNG5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACNG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNG5 Gene

Domains for CACNG5 Gene

Gene Families for CACNG5 Gene

HGNC:
  • CACN :Calcium channel subunits

Suggested Antigen Peptide Sequences for CACNG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UF02

UniProtKB/Swiss-Prot:

CCG5_HUMAN :
  • Q9UF02
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with CACNG5: view

Function for CACNG5 Gene

Molecular function for CACNG5 Gene

GENATLAS Biochemistry: calcium channel,voltage-dependent,gamma subunit 5
UniProtKB/Swiss-Prot Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Gene Ontology (GO) - Molecular Function for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity TAS 10613843
GO:0005515 protein binding --
GO:0015075 ion transmembrane transporter activity TAS 10613843
genes like me logo Genes that share ontologies with CACNG5: view

miRNA for CACNG5 Gene

miRTarBase miRNAs that target CACNG5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CACNG5 Gene

Localization for CACNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNG5 Gene

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNG5 Gene COMPARTMENTS Subcellular localization image for CACNG5 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density ISS --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ISS --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with CACNG5: view

Pathways for CACNG5 Gene

genes like me logo Genes that share pathways with CACNG5: view

Interacting Proteins for CACNG5 Gene

Gene Ontology (GO) - Biological Process for CACNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10613843
GO:0070588 calcium ion transmembrane transport IEA --
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS --
genes like me logo Genes that share ontologies with CACNG5: view

Compounds for CACNG5 Gene

(1) HMDB Compounds for CACNG5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CACNG5: view

Transcripts for CACNG5 Gene

mRNA/cDNA for CACNG5 Gene

(5) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNG5 Gene

Calcium channel, voltage-dependent, gamma subunit 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CACNG5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNG5 Gene

No ASD Table

Relevant External Links for CACNG5 Gene

GeneLoc Exon Structure for
CACNG5
ECgene alternative splicing isoforms for
CACNG5

Expression for CACNG5 Gene

mRNA expression in normal human tissues for CACNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNG5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.5), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Nucleus accumbens (basal ganglia) (4.7), Brain - Putamen (basal ganglia) (4.6), Brain - Hypothalamus (4.4), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNG5 Gene

SOURCE GeneReport for Unigene cluster for CACNG5 Gene Hs.278907

genes like me logo Genes that share expressions with CACNG5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CACNG5 Gene

Orthologs for CACNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACNG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACNG5 35
  • 99.88 (n)
  • 100 (a)
CACNG5 36
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACNG5 35
  • 88 (n)
  • 91.64 (a)
CACNG5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNG5 35
  • 92.24 (n)
  • 97.45 (a)
CACNG5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacng5 35
  • 89.45 (n)
  • 97.09 (a)
Cacng5 16
Cacng5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacng5 35
  • 89.45 (n)
  • 96.73 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
LOC100859614 35
  • 83.15 (n)
  • 93.82 (a)
lizard
(Anolis carolinensis)
Reptilia CACNG5 36
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cacng5a 36
  • 86 (a)
OneToMany
cacng5b 36
  • 90 (a)
OneToMany
LOC100331116 35
  • 80.48 (n)
  • 90.18 (a)
Species with no ortholog for CACNG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACNG5 Gene

ENSEMBL:
Gene Tree for CACNG5 (if available)
TreeFam:
Gene Tree for CACNG5 (if available)

Paralogs for CACNG5 Gene

Paralogs for CACNG5 Gene

Selected SIMAP similar genes for CACNG5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CACNG5: view

Variants for CACNG5 Gene

Sequence variations from dbSNP and Humsavar for CACNG5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs722195 -- 66,875,951(-) AGGAT(A/G)TGACA upstream-variant-2KB
rs722617 -- 66,876,665(+) GAGGA(C/T)ACTTT upstream-variant-2KB
rs1002327 -- 66,878,497(-) GTCTG(A/G)GGCAG intron-variant
rs1395823 -- 66,880,019(+) tccca(A/T)ccttg intron-variant
rs2286676 -- 66,878,917(+) TGGAC(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNG5 Gene

Variant ID Type Subtype PubMed ID
nsv833521 CNV Loss 17160897

Relevant External Links for CACNG5 Gene

HapMap Linkage Disequilibrium report
CACNG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNG5 Gene

Disorders for CACNG5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CACNG5 Gene including...

Search for CACNG5 Gene in MalaCards »

Relevant External Links for CACNG5

Genetic Association Database (GAD)
CACNG5
Human Genome Epidemiology (HuGE) Navigator
CACNG5
genes like me logo Genes that share disorders with CACNG5: view

No data available for UniProtKB/Swiss-Prot for CACNG5 Gene

Publications for CACNG5 Gene

  1. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PMID: 10613843) Burgess D.L. … Noebels J.L. (Genome Res. 1999) 2 3 4
  2. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PMID: 11738816) Chu P.-J. … Best P.M. (Gene 2001) 3 4
  3. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PMID: 11927536) Moss F.J. … Dolphin A.C. (EMBO J. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. (PMID: 21057379) Curtis D. … Gurling H.M. (Psychiatr. Genet. 2011) 3 48

Products for CACNG5 Gene

Sources for CACNG5 Gene

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