CACNG5 Gene
protein-coding GIFtS: 53
GCID: GC17P064873
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|
calcium channel, voltage-dependent, gamma subunit 5
| |
Aliases
for CACNG5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Channel, Voltage-Dependent, Gamma Subunit 51 2 | | Neuronal Voltage-Gated Calcium Channel Gamma-5 Subunit2 3 | | Transmembrane AMPAR Regulatory Protein Gamma-52 3 | | TARP Gamma-52 3 | | Voltage-Dependent Calcium Channel Gamma-5 Subunit2 |
Export aliases for CACNG5 gene to outside databasesPrevious GC identifers: GC17M063533 GC17M066599 GC17P065290 GC17P065423 GC17P062303 GC17P060262 |
Summaries
for CACNG5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CACNG5:
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulateboth trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-memberprotein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP anda calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. (providedby RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: CCG5_HUMAN, Q9UF02Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gatingproperties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPAreceptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize thecalcium channel in an inactivated (closed) state (By similarity)
|
Genomic Views
for CACNG5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CACNG5 gene promoter:
C/EBPbeta Brachyury Lmo2 IRF-1 Cdc5 RORalpha2 Evi-1 S8 ZIC2/Zic2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CACNG5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24CACNG5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P064873: view genomic region
(about GC identifiers)
Start:
|
64,831,235 bp from pter |
End:
|
64,881,603 bp from pter |
Size:
|
50,369 bases |
Orientation:
|
plus strand |
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Proteins
for CACNG5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCG5_HUMAN, Q9UF02 (See
protein sequence)Recommended Name: Voltage-dependent calcium channel gamma-5 subunit Size: 275 amino acids; 30903 Da
Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as anauxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cellmembrane, postsynaptic density (By similarity)
Secondary accessions: A8K2A6 Q547R3 Q8WXS7 Q9UHM3Explore the universe of human proteins at neXtProt for CACNG5: NX_Q9UF02
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UF02
CACNG5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_665810.1
ENSEMBL proteins: ENSP00000436836 ENSP00000303092 ENSP00000169565
Human Recombinant Protein Products for CACNG5:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0014069 | postsynaptic density |
ISS | -- | | GO:0030054 | cell junction |
IEA | -- | | GO:0032281 | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
ISS | -- | | GO:0045211 | postsynaptic membrane |
IEA | -- |
CACNG5 for ontologies About GeneDecksing
CACNG5 Antibody Products:
Assay Products for CACNG5: |
Protein
Domains /
Families
for CACNG5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CACNG5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UF02ProtoNet protein and cluster: Q9UF02 1 Blocks protein family: IPB008369 Voltage-dependent calcium channel gamma-5 subunit signature
UniProtKB/Swiss-Prot: CCG5_HUMAN, Q9UF02Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily |
Function
for CACNG5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCG5_HUMAN, Q9UF02Function: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gatingproperties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPAreceptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize thecalcium channel in an inactivated (closed) state (By similarity) Genatlas biochemistry entry for CACNG5:calcium channel,voltage-dependent,gamma subunit 5
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CACNG5 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CACNG5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG5 |
|
Pathways & Interactions
for CACNG5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DREAM Repression and Dynorphin Expression | | | 2 | PKC-Theta Pathway | | | 3 | Sweet Taste Signaling | | | 4 | Activation of cAMP-Dependent PKA | | | 5 | NFAT and Cardiac Hypertrophy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CACNG5
5/37 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNG5 (see all 37)
1  GeneGo (Thomson Reuters) Pathway for CACNG5
1  BioSystems Pathway for CACNG5
5 
Kegg Pathways (Kegg details for CACNG5):
CACNG5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNG5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for CACNG5 (ENSP000001695654) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
TAS | 10613843 | | GO:0034220 | ion transmembrane transport |
-- | -- | | GO:0051925 | regulation of calcium ion transport via voltage-gated calcium channel activity |
-- | -- | | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
ISS | -- |
CACNG5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CACNG5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CACNG5
1 HMDB Compound for CACNG5 About this table
Search CenterWatch for drugs/clinical trials and news about CACNG5 / CCG5
|
Transcripts
for CACNG5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CACNG5 gene (2 alternative transcripts): NM_145811.2 NM_014404.1 Unigene Cluster for CACNG5: Calcium channel, voltage-dependent, gamma subunit 5 Hs.278907 [show with all ESTs]Unigene Representative Sequence: AK2901713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533854(uc010wqi.2 uc010wqj.2) ENST00000307139 ENST00000169565
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CACNG5 (NM_145811) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNG5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG5 |
Additional cDNA sequence: AF361351.1 AF458898.1 AK290171.1 BC101607.1 BC101633.1 2 DOTS entries: DT.97824194 DT.75104055 5 AceView cDNA sequences: AF148220 AF361351 NM_145811 AF458898 NM_014404
GeneLoc Exon Structure
|
Expression
for CACNG5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CACNG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGGCCCC
About this image
See CACNG5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNG5
SOURCE GeneReport for Unigene cluster: Hs.278907
SABiosciences Custom PCR Arrays for CACNG5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG5 |
Orthologs
for CACNG5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CACNG5 gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008596141 |
voltage-dependent calcium channel gamma-5 subunit-like |
83.15(n)
93.82(a) |
|
100859614 XM_003642343.1 XP_003642391.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CACNG56 |
-- |
93(a) |
1 ↔ 1 |
GL343250.1(45257-73260) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7974091 |
voltage-dependent calcium channel gamma-5 subunit-like |
77.33(n)
90.18(a) |
|
797409 XM_001337836.3 XP_001337872.1 |
ENSEMBL Gene Tree for CACNG5 (if available)
TreeFam Gene Tree for CACNG5 (if available) |
Paralogs
for CACNG5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CACNG5 gene
- CACNG42 CACNG72 CACNG22 CACNG82 CACNG32
3 SIMAP similar genes for CACNG5 using alignment to 1 protein entry: CCG5_HUMAN:CACNG7 CACNG4 CACNG8
CACNG5 for paralogs About GeneDecksing
|
Genomic Variants
for CACNG5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CACNG5 (64831235 - 64881603 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CACNG5
1 CNV: 5027 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNG5 |
|
Disorders
/ Diseases
for CACNG5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CACNG5 for disorders About GeneDecksing
OMIM gene information: 606405
OMIM disorders: --
2  diseases for CACNG5: About MalaCardsbipolar disorder schizophrenia
Human Genome Epidemiology (HuGE) Navigator: CACNG5 (1 document)
Export disorders for CACNG5 gene to outside databases
|
Publications
for CACNG5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CACNG5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CACNG5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PubMed id 10613843)1, 2, 3 Burgess D.L.... Noebels J.L. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. (PubMed id 11927536)1, 2 Moss F.J.... Dolphin A.C. (2002)
- Calcium channel gamma subunits provide insights into the evolution of this gene family. (PubMed id 11738816)1, 2 Chu P.-J.... Best P.M. (2001)
- Case-case genome-wide association analysis shows mark ers differentially associated with schizophrenia and bipolar disorder and impli cates calcium channel genes. (PubMed id 21057379)1 Curtis D....Gurling H.M. (2011)
- Calcium channel gamma subunits: a functionally divers e protein family. (PubMed id 17652770)1 Chen R.S....Best P.M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. (PubMed id 11170751)1 Burgess D.L.... Noebels J.L. (2001)
|
External Searches for CACNG5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CACNG5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CACNG5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CACNG5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CACNG5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CACNG5 gene:
Search GeneIP for patents involving CACNG5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CACNG5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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