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CACNG4 Gene

protein-coding   GIFtS: 58
GCID: GC17P064961

Calcium Channel, Voltage-Dependent, Gamma Subunit 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 41 2
Neuronal Voltage-Gated Calcium Channel Gamma-4 Subunit2 3
Transmembrane AMPAR Regulatory Protein Gamma-42 3
TARP Gamma-42 3
Voltage-Dependent Calcium Channel Gamma-4 Subunit2

External Ids:    HGNC: 14081   Entrez Gene: 270922   Ensembl: ENSG000000754617   OMIM: 6064045   UniProtKB: Q9UBN13   

Export aliases for CACNG4 gene to outside databases

Previous GC identifers: GC17M063387 GC17M066451 GC17P065378 GC17P065511 GC17P062391 GC17P060402


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CACNG4 Gene:
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate
both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse
eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members,
a type II TARP and a calcium channel gamma subunit. (provided by RefSeq, Dec 2010)

GeneCards Summary for CACNG4 Gene:
CACNG4 (calcium channel, voltage-dependent, gamma subunit 4) is a protein-coding gene. Diseases associated with CACNG4 include childhood absence epilepsy, and hypertrophic cardiomyopathy. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG7.

UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
activation, deactivation and desensitization and by mediating their resensitization. Does not show
subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium
channel in an inactivated (closed) state

Gene Wiki entry for CACNG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CACNG4 gene promoter:
         TBP   MyoD   Lmo2   Tal-1beta   Roaz   E47   MZF-1   TFIID   SEF-1 (1)   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCACNG4 promoter sequence
   Search Chromatin IP Primers for CACNG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACNG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24

CACNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P064961:  view genomic region     (about GC identifiers)

Start:
64,960,980 bp from pter      End:
65,029,518 bp from pter
Size:
68,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1 (See protein sequence)
Recommended Name: Voltage-dependent calcium channel gamma-4 subunit  
Size: 327 amino acids; 36579 Da
Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as
an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2,
GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity)
Secondary accessions: B2RCK0

Explore the universe of human proteins at neXtProt for CACNG4: NX_Q9UBN1

Explore proteomics data for CACNG4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn45
  • Modification sites at PhosphoSitePlus

  • See CACNG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055220.1  
    ENSEMBL proteins: 
     ENSP00000262138  
    Reactome Protein details: Q9UBN1

    CACNG4 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    CACNG4 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CACN: Calcium channel subunits

    3 InterPro protein domains:
     IPR008368 VDCC_gsu
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR005423 VDCC_g4su

    Graphical View of Domain Structure for InterPro Entry Q9UBN1

    ProtoNet protein and cluster: Q9UBN1

    2 Blocks protein domains:
    IPB005423 Voltage-dependent calcium channel gamma-4 subunit signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1
    Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily


    CACNG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCG4_HUMAN, Q9UBN1
    Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
    their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of
    activation, deactivation and desensitization and by mediating their resensitization. Does not show
    subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium
    channel in an inactivated (closed) state

         Genatlas biochemistry entry for CACNG4:
    calcium channel,voltage-dependent,gamma subunit 4

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005245voltage-gated calcium channel activity IEA--
         
    CACNG4 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cacng4):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  normal 

    CACNG4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cacng4tm1Ran for CACNG4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CACNG4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CACNG4

    miRNA
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    miRTarBase miRNAs that target CACNG4:
    hsa-mir-335-5p (MIRT017598)

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    Selected qRT-PCR Assays for microRNAs that regulate CACNG4 (see all 29):
    hsa-miR-3128 hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-29c hsa-let-7c hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCACNG4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCG4_HUMAN, Q9UBN1: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10613843
    GO:0005891voltage-gated calcium channel complex IEA--
    GO:0016021integral component of membrane ----
    GO:0030666endocytic vesicle membrane TAS--

    CACNG4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CACNG4 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression0.44
    Caspase Cascade0.36
    BMP Pathway0.44
    Calpain Protease Regulates Cellular Mechanics0.31
    nNOS Signaling in Skeletal Muscle0.37
    Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels0.00
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    Fc-EpsilonRI Pathway0.49
    TCR Signaling0.68
    PDGF Pathway0.39
    ITK and TCR Signaling0.54
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CACNG4 (see all 37)
        Caspase Cascade
    Fc-GammaR Pathway
    Intracellular Calcium Signaling
    PDGF Pathway
    BMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for CACNG4
        Transcription CREB pathway

    1 BioSystems Pathway for CACNG4
        Arrhythmogenic right ventricular cardiomyopathy


    2 Reactome Pathways for CACNG4
        Trafficking of AMPA receptors
    Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels


    Selected Kegg Pathways  (Kegg details for CACNG4) (see all 7):
        MAPK signaling pathway
    Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes
    Oxytocin signaling pathway
    Hypertrophic cardiomyopathy (HCM)


    CACNG4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CACNG4: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CACNG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CACNG4 (ENSP000002621384) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNG2ENSP000003001054STRING: ENSP00000300105
    CACNG3ENSP000000052844STRING: ENSP00000005284
    CACNG8ENSP000002704584STRING: ENSP00000270458
    AKAP5ENSP000003156154STRING: ENSP00000315615
    EPB41L1ENSP000003371684STRING: ENSP00000337168
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10613843
    GO:0007268synaptic transmission TAS--
    GO:0019226transmission of nerve impulse IEA--
    GO:0051899membrane depolarization TAS--
    GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--

    CACNG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CACNG4 (CCG4)

    1 HMDB Compound for CACNG4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CACNG4 gene: 
    NM_014405.3  

    Unigene Cluster for CACNG4:

    Calcium channel, voltage-dependent, gamma subunit 4
    Hs.514423  [show with all ESTs]
    Unigene Representative Sequence: NM_014405
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262138(uc002jft.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CACNG4 (see all 29):
    hsa-miR-3128 hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-29c hsa-let-7c hsa-miR-371-5p
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      QuantiFast Probe-based Assays in human, mouse, rat CACNG4

    Additional mRNA sequence: 

    AF162692.1 AK055232.1 AK315149.1 AL713655.1 AL831834.1 BC004504.2 BC032765.1 BC034532.1 

    3 DOTS entries:

    DT.446043  DT.100717805  DT.100751044 

    Selected AceView cDNA sequences (see all 102):

    AL138245 Z40814 BQ954202 AW439321 BC034532 AA970202 AL526464 AI093112 
    T16001 AI423159 AI146595 AK055232 BM728400 NM_014405 AL831834 BF337560 
    F11272 AI498760 BC004504 AI560278 BI914516 BC032765 BU956275 BG911673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CACNG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAAGCTG
    CACNG4 Expression
    About this image


    CACNG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Meninges
    CACNG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CACNG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514423
        Pathway & Disease-focused RT2 Profiler PCR Array including CACNG4: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CACNG4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacng41 , 5 calcium channel, voltage-dependent, gamma subunit 41, 5 92.25(n)1
    98.17(a)1
      11 (70.29 cM)5
    543771  NM_019431.21  NP_062304.11 
     1077323575 
    chicken
    (Gallus gallus)
    Aves CACNG41 calcium channel, voltage-dependent, gamma subunit 4 79.51(n)
    88.69(a)
      373924  NM_204132.1  NP_989463.1 
    lizard
    (Anolis carolinensis)
    Reptilia CACNG46
    calcium channel, voltage-dependent, gamma subunit ...
    86(a)
    1 ↔ 1
    GL343250.1(206620-318155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004865541 voltage-dependent calcium channel gamma-4 subunit-like 77.04(n)
    81.78(a)
      100486554  XM_002943342.2  XP_002943388.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7942221 voltage-dependent calcium channel gamma-4 subunit-like 71.67(n)
    76.25(a)
      794222  XM_001334097.3  XP_001334133.2 


    ENSEMBL Gene Tree for CACNG4 (if available)
    TreeFam Gene Tree for CACNG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CACNG4 gene
    CACNG72  CACNG52  CACNG22  CACNG82  CACNG32  
    4 SIMAP similar genes for CACNG4 using alignment to 1 protein entry:     CCG4_HUMAN:
    CACNG2    CACNG8    CACNG3    CACNG5

    CACNG4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CACNG4 (see all 1615)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37602621,2
    C,F--64958987(-) TCTTCA/CTCTTC 1 -- us2k16Minor allele frequency- C:0.27EA WA NA 1842
    rs1426712861,2
    C--64959013(+) GGAGG-/GGAGGAGG 1 -- us2k10--------
    rs2014008621,2
    C--64959015(-) CCTCCC/TCCCCT 1 -- us2k10--------
    rs1418691361,2
    --64959097(+) TGGCT-/GGGGGGGGG
    GGGGGGGGGGGG
    GTTAG
    1 -- cds10--------
    rs1392420731,2
    --64959123(+) ACCCTA/GTTCTG 1 -- us2k10--------
    rs1432575841,2
    --64959249(+) CCCTCA/GTCCTT 1 -- us2k10--------
    rs781899371,2
    C,F--64959294(+) CAGAAG/AGGGCC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1506468991,2
    C--64959299(+) GGGCC-/AACA  
            
    AACAA
    1 -- us2k10--------
    rs1142671581,2
    C--64959360(+) GTTTTC/TTCCCT 1 -- us2k10--------
    rs1485343051,2
    --64959361(+) TTTTTA/TCCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CACNG4 (64960980 - 65029518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CACNG4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716125CNV Deletion23290073
    esv1634500CNV Deletion17803354
    esv2716124CNV Deletion23290073
    esv2664511CNV Deletion23128226
    esv2716126CNV Deletion23290073
    esv2669263CNV Deletion23128226
    nsv469731CNV Loss16826518
    nsv828090CNV Loss20364138
    esv27303CNV Loss19812545
    nsv833521CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CACNG4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606404    OMIM disorders: --

    7 diseases for CACNG4:    
    About MalaCards
    childhood absence epilepsy    hypertrophic cardiomyopathy    neuronitis    dilated cardiomyopathy
    meningitis    multiple sclerosis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CACNG4:
    Childhood absence epilepsy

    CACNG4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CACNG4
    Human Genome Epidemiology (HuGE) Navigator: CACNG4 (4 documents)

    Export disorders for CACNG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CACNG4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CACNG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PubMed id 10613843)1, 2, 3 Burgess D.L.... Noebels J.L. (Genome Res. 1999)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PubMed id 20378664)1, 4 Sombekke M.H....Uitdehaag B.M. (Mult. Scler. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    7. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PubMed id 21172611)2 Kato A.S.... Bredt D.S. (Neuron 2010)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. (PubMed id 18304745)1 Sager C....Hollmann M. (Neuroscience 2009)
    10. Calcium channel gamma subunits: a functionally diverse protein family. (PubMed id 17652770)1 Chen R.S....Best P.M. (Cell Biochem. Biophys. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 27092 HGNC: 1408 AceView: CACNG4 Ensembl:ENSG00000075461 euGenes: HUgn27092
    ECgene: CACNG4 Kegg: 27092 H-InvDB: CACNG4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CACNG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CACNG4 gene:
    Search GeneIP for patents involving CACNG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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