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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CACNG4 Gene

protein-coding GIFtS: 56
GCID: GC17P064961

calcium channel, voltage-dependent, gamma subunit 4

Explore 2 diseases affiliated with
CACNG4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 4¹ ²		MGC11138¹
Neuronal Voltage-Gated Calcium Channel Gamma-4 Subunit² ³		MGC24983¹
Transmembrane AMPAR Regulatory Protein Gamma-4² ³		Voltage-Dependent Calcium Channel Gamma-4 Subunit²
TARP Gamma-4² ³

External Ids:	HGNC: 1408¹	Entrez Gene: 27092²	Ensembl: ENSG00000075461⁷	OMIM: 606404⁵	UniProtKB: Q9UBN1³

Export aliases for CACNG4 gene to outside databases

Previous GC identifers: GC17M063387 GC17M066451 GC17P065378 GC17P065511 GC17P062391 GC17P060402

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CACNG4:

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both

trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein

subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a

calcium channel gamma subunit. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes

their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of

activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific

AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated

(closed) state

Gene Wiki entry for CACNG4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CACNG4 gene promoter:
TBP MyoD Lmo2 Tal-1beta Roaz E47 MZF-1 TFIID SEF-1 (1) c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CACNG4 promoter sequence

Search SABiosciences Chromatin IP Primers for CACNG4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24

CACNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P064961: view genomic region (about GC identifiers)

Start:	64,961,013 bp from pter	End:	65,029,518 bp from pter
Size:	68,506 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1 (See protein sequence)

Recommended Name: Voltage-dependent calcium channel gamma-4 subunit

Size: 327 amino acids; 36579 Da

Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an

auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,

CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: B2RCK0

Explore the universe of human proteins at neXtProt for CACNG4: NX_Q9UBN1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBN1

CACNG4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055220.1

ENSEMBL proteins:

ENSP00000262138

Reactome Protein details: Q9UBN1
Human Recombinant Protein Products for CACNG4:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	10613843
GO:0005891	voltage-gated calcium channel complex	IEA	--
GO:0030666	endocytic vesicle membrane	TAS	--
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	ISS	--

CACNG4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CACNG4 for domains About GeneDecksing

3 InterPro domains/families:

IPR008368 VDCC_gsu

IPR004031 PMP22/EMP/MP20/Claudin

IPR005423 VDCC_g4su

Graphical View of Domain Structure for InterPro Entry Q9UBN1

ProtoNet protein and cluster: Q9UBN1

2 Blocks protein families:

IPB005423 Voltage-dependent calcium channel gamma-4 subunit signature

IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CCG4_HUMAN, Q9UBN1

Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CCG4_HUMAN, Q9UBN1

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes

their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of

activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific

AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated

(closed) state

Genatlas biochemistry entry for CACNG4:

calcium channel,voltage-dependent,gamma subunit 4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005245	voltage-gated calcium channel activity	IEA	--

CACNG4 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cacng4):

behavior/neurological

growth/size

mortality/aging

nervous system

normal

CACNG4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cacng4^tm1Ran for CACNG4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CACNG4

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		hsa-miR-3128 hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-29c hsa-let-7c hsa-miR-371-5p

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

DREAM Repression and Dynorphin Expression

DREAM Repression and Dynorphin Expression	1.00	Caspase Cascade	0.24
BMP Pathway	0.44	Calpain Protease Regulates Cellular Mechanics	0.22
nNOS Signaling in Skeletal Muscle	0.37

PKC-Theta Pathway

PKC-Theta Pathway	1.00	Fc-EpsilonRI Pathway	0.42
TCR Signaling	0.68	PDGF Pathway	0.35
ITK and TCR Signaling	0.54

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CACNG4

Transcription CREB pathway

5/37 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNG4 (see all 37)

	Caspase Cascade
	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	PDGF Pathway
	BMP Pathway

1 GeneGo (Thomson Reuters) Pathway for CACNG4

Transcription CREB pathway

1 BioSystems Pathway for CACNG4

Arrhythmogenic right ventricular cardiomyopathy

5/6 Reactome Pathways for CACNG4 (see all 6)

	Trafficking of AMPA receptors
	Transmission across Chemical Synapses
	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

5 Kegg Pathways (Kegg details for CACNG4):

	MAPK signaling pathway
	Cardiac muscle contraction
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathy

CACNG4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CACNG4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for CACNG4 (ENSP00000262138⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNG2	ENSP00000300105⁴	STRING: ENSP00000300105
CACNG3	ENSP00000005284⁴	STRING: ENSP00000005284
CACNG8	ENSP00000270458⁴	STRING: ENSP00000270458
CAMK2D	ENSP00000339740⁴	STRING: ENSP00000339740
AKAP5	ENSP00000315615⁴	STRING: ENSP00000315615

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	10613843
GO:0007268	synaptic transmission	TAS	--
GO:0019226	transmission of nerve impulse	--	--
GO:0051899	membrane depolarization	TAS	--
GO:0051925	regulation of calcium ion transport via voltage-gated calcium channel activity	--	--

CACNG4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CACNG4

1 HMDB Compound for CACNG4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CACNG4 / CCG4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CACNG4 gene:

NM_014405.3

Unigene Cluster for CACNG4:

Calcium channel, voltage-dependent, gamma subunit 4

Hs.514423 [show with all ESTs]

Unigene Representative Sequence: NM_014405

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000262138(uc002jft.2)

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		hsa-miR-3128 hsa-miR-4307 hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-29c hsa-let-7c hsa-miR-371-5p

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Additional cDNA sequence:

AF162692.1 AK055232.1 AK315149.1 AL713655.1 AL831834.1 BC004504.2 BC032765.1 BC034532.1

3 DOTS entries:

DT.446043 DT.100717805 DT.100751044

24/102 AceView cDNA sequences (see all 102):

BF337560 BI914516 Z40814 BQ954202 BC004504 AK055232 T16001 BC034532

AA970202 AL831834 AI093112 AL526464 AI423159 AI560278 BM728400 AW439321

AL138245 NM_014405 AI146595 F11272 AI498760 F08932 BE743242 AW961873

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CACNG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAAGCTG

About this image

CACNG4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Brain

Eye

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CACNG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNG4

SOURCE GeneReport for Unigene cluster: Hs.514423

SABiosciences Expression via Pathway-Focused PCR Array including CACNG4:

Neuronal Ion Channels in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CACNG4 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CACNG4¹	calcium channel, voltage-dependent, gamma subunit 4	79.51(n) 88.69(a)		373924 NM_204132.1 NP_989463.1
lizard (Anolis carolinensis)	Reptilia	CACNG4⁶	--	89(a)	1 ↔ 1	GL343250.1(295532-318155)
zebrafish (Danio rerio)	Actinopterygii	LOC794222¹	voltage-dependent calcium channel gamma-4 subunit-like	71.67(n) 76.25(a)		794222 XM_001334097.2 XP_001334133.2

ENSEMBL Gene Tree for CACNG4 (if available)
TreeFam Gene Tree for CACNG4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CACNG4 gene

CACNG7² CACNG5² CACNG2² CACNG8² CACNG3²

4 SIMAP similar genes for CACNG4 using alignment to 1 protein entry: CCG4_HUMAN:

CACNG2 CACNG8 CACNG3 CACNG5

CACNG4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3760262^1,2	C,F	--	64958987(-)	`TCTTCA/CTCTTC`	1	--	us2k¹		6		EA WA NA	1842
rs142671286^1,2	C	--	64959013(+)	`GGAGG-/GGAGGAGG`	1	--	us2k¹		0	--	--	--	--
rs201400862^1,2	C	--	64959015(-)	`CCTCCC/TCCCCT`	1	--	us2k¹		0	--	--	--	--
rs141869136^1,2		--	64959097(+)	`TGGCT-/GGGGGGGGG GGGGGGGGGGGGGTTAG`	1	--	us2k¹		0	--	--	--	--
rs139242073^1,2		--	64959123(+)	`ACCCTA/GTTCTG`	1	--	us2k¹		0	--	--	--	--
rs143257584^1,2		--	64959249(+)	`CCCTCA/GTCCTT`	1	--	us2k¹		0	--	--	--	--
rs78189937^1,2	F	--	64959294(+)	`CAGAAG/AGGGCC`	1	--	us2k¹		1		WA	118
rs150646899^1,2		--	64959299(+)	`GGGCC-/AACA AACAA`	1	--	us2k¹		0	--	--	--	--
rs114267158^1,2	C	--	64959360(+)	`GTTTTC/TTCCCT`	1	--	us2k¹		0	--	--	--	--
rs148534305^1,2		--	64959361(+)	`TTTTTA/TCCCTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CACNG4 (64961013 - 65029518 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CACNG4
4 CNVs: 5027 67246 67247 2232

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CACNG4 for disorders           About GeneDecksing

OMIM gene information: 606404    OMIM disorders: --

2 diseases for CACNG4:    About MalaCards

multiple sclerosis neuronitis

1 disease from the University of Copenhagen DISEASES database for CACNG4:

Childhood absence epilepsy

Human Genome Epidemiology (HuGE) Navigator: CACNG4 (4 documents)

Export disorders for CACNG4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CACNG4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CACNG4)

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Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. (PubMed id 10613843)^{1, 2, 3} Burgess D.L.... Noebels J.L. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)¹ Long P....Rose S. (2012)
Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PubMed id 21172611)² Kato A.S.... Bredt D.S. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Analysis of multiple candidate genes in association w ith phenotypes of multiple sclerosis. (PubMed id 20378664)¹ Sombekke M.H....Uitdehaag B.M. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. (PubMed id 18304745)¹ Sager C....Hollmann M. (2009)
Calcium channel gamma subunits: a functionally divers e protein family. (PubMed id 17652770)¹ Chen R.S....Best P.M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27092	HGNC: 1408	AceView: CACNG4	Ensembl:ENSG00000075461	euGenes: HUgn27092
ECgene: CACNG4	Kegg: 27092	H-InvDB: CACNG4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CACNG4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CACNG4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CACNG4 gene:
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CACNG4 Gene

calcium channel, voltage-dependent, gamma subunit 4

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CACNG4 Gene

calcium channel, voltage-dependent, gamma subunit 4

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