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Aliases for CACNG3 Gene

Aliases for CACNG3 Gene

  • Calcium Channel, Voltage-Dependent, Gamma Subunit 3 2 3
  • Neuronal Voltage-Gated Calcium Channel Gamma-3 Subunit 4
  • Transmembrane AMPAR Regulatory Protein Gamma-3 4
  • TARP Gamma-3 4

External Ids for CACNG3 Gene

Previous GeneCards Identifiers for CACNG3 Gene

  • GC16P023676
  • GC16P024366
  • GC16P024194
  • GC16P024233
  • GC16P024174
  • GC16P022358

Summaries for CACNG3 Gene

Entrez Gene Summary for CACNG3 Gene

  • The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]

GeneCards Summary for CACNG3 Gene

CACNG3 (Calcium Channel, Voltage-Dependent, Gamma Subunit 3) is a Protein Coding gene. Diseases associated with CACNG3 include juvenile absence epilepsy. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG2.

UniProtKB/Swiss-Prot for CACNG3 Gene

  • Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Gene Wiki entry for CACNG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNG3 Gene

Genomics for CACNG3 Gene

Regulatory Elements for CACNG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACNG3 Gene

Start:
24,255,553 bp from pter
End:
24,362,801 bp from pter
Size:
107,249 bases
Orientation:
Plus strand

Genomic View for CACNG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNG3 Gene

Proteins for CACNG3 Gene

  • Protein details for CACNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60359-CCG3_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-3 subunit
    Protein Accession:
    O60359
    Secondary Accessions:

    Protein attributes for CACNG3 Gene

    Size:
    315 amino acids
    Molecular mass:
    35549 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).

neXtProt entry for CACNG3 Gene

Proteomics data for CACNG3 Gene at MOPED

Post-translational modifications for CACNG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACNG3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNG3 Gene

Domains for CACNG3 Gene

Gene Families for CACNG3 Gene

HGNC:
  • CACN :Calcium channel subunits

Protein Domains for CACNG3 Gene

Suggested Antigen Peptide Sequences for CACNG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60359

UniProtKB/Swiss-Prot:

CCG3_HUMAN :
  • O60359
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with CACNG3: view

Function for CACNG3 Gene

Molecular function for CACNG3 Gene

GENATLAS Biochemistry: calcium voltage-gated channel (VDCC),L type,dihydropyridine (DPH) sensitive,gamma regulatory subunit 3,neuronal
UniProtKB/Swiss-Prot Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Gene Ontology (GO) - Molecular Function for CACNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity NAS 10221464
genes like me logo Genes that share ontologies with CACNG3: view
genes like me logo Genes that share phenotypes with CACNG3: view

Animal Models for CACNG3 Gene

MGI Knock Outs for CACNG3:

miRNA for CACNG3 Gene

miRTarBase miRNAs that target CACNG3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CACNG3 Gene

Localization for CACNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNG3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNG3 Gene COMPARTMENTS Subcellular localization image for CACNG3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CACNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005891 voltage-gated calcium channel complex NAS 10221464
GO:0016021 integral component of membrane --
GO:0030666 endocytic vesicle membrane TAS --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ISS --
genes like me logo Genes that share ontologies with CACNG3: view

Pathways for CACNG3 Gene

genes like me logo Genes that share pathways with CACNG3: view

Gene Ontology (GO) - Biological Process for CACNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport NAS 10221464
GO:0007268 synaptic transmission TAS --
GO:0070588 calcium ion transmembrane transport IEA --
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS --
genes like me logo Genes that share ontologies with CACNG3: view

Compounds for CACNG3 Gene

(1) HMDB Compounds for CACNG3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CACNG3: view

Transcripts for CACNG3 Gene

mRNA/cDNA for CACNG3 Gene

(54) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNG3 Gene

Calcium channel, voltage-dependent, gamma subunit 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNG3 Gene

No ASD Table

Relevant External Links for CACNG3 Gene

GeneLoc Exon Structure for
CACNG3
ECgene alternative splicing isoforms for
CACNG3

Expression for CACNG3 Gene

mRNA expression in normal human tissues for CACNG3 Gene

mRNA differential expression in normal tissues according to GTEx for CACNG3 Gene

This gene is overexpressed in Brain - Cortex (8.9), Brain - Frontal Cortex (BA9) (8.2), Brain - Anterior cingulate cortex (BA24) (8.0), Brain - Amygdala (5.6), Brain - Hippocampus (5.2), Brain - Nucleus accumbens (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.5), and Brain - Putamen (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNG3 Gene

SOURCE GeneReport for Unigene cluster for CACNG3 Gene Hs.7235

genes like me logo Genes that share expressions with CACNG3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CACNG3 Gene

Orthologs for CACNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACNG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACNG3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACNG3 35
  • 94.18 (n)
  • 99.37 (a)
CACNG3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNG3 35
  • 95.45 (n)
  • 99.68 (a)
CACNG3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacng3 35
  • 90.58 (n)
  • 98.73 (a)
Cacng3 16
Cacng3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACNG3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNG3 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacng3 35
  • 90.48 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves CACNG3 35
  • 79.72 (n)
  • 89.81 (a)
CACNG3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacng3 35
  • 76.72 (n)
  • 83.81 (a)
zebrafish
(Danio rerio)
Actinopterygii cacng3a 36
  • 62 (a)
OneToMany
cacng3b 35
  • 73.27 (n)
  • 82.14 (a)
cacng3b 36
  • 82 (a)
OneToMany
Species with no ortholog for CACNG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACNG3 Gene

ENSEMBL:
Gene Tree for CACNG3 (if available)
TreeFam:
Gene Tree for CACNG3 (if available)

Paralogs for CACNG3 Gene

Paralogs for CACNG3 Gene

Selected SIMAP similar genes for CACNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CACNG3: view

Variants for CACNG3 Gene

Sequence variations from dbSNP and Humsavar for CACNG3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs714822 -- 24,355,195(+) TGGCA(C/G)GATCA intron-variant
rs723722 -- 24,293,393(-) CTTCA(C/T)TGGCT intron-variant
rs723723 -- 24,293,659(-) ATATC(G/T)TCTAG intron-variant
rs736485 -- 24,324,792(+) TGTTC(C/T)TCCAT intron-variant
rs739747 -- 24,288,245(-) AACAG(A/T)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNG3 Gene

Variant ID Type Subtype PubMed ID
nsv833174 CNV Gain 17160897
esv34056 CNV Loss 18971310
esv271292 CNV Insertion 20981092
esv272515 CNV Insertion 20981092
esv2714110 CNV Deletion 23290073
esv2714111 CNV Deletion 23290073
esv1634914 CNV Deletion 17803354
esv2714112 CNV Deletion 23290073
esv2714113 CNV Deletion 23290073

Relevant External Links for CACNG3 Gene

HapMap Linkage Disequilibrium report
CACNG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNG3 Gene

Disorders for CACNG3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CACNG3 Gene including...

Search for CACNG3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CACNG3 Gene

Relevant External Links for CACNG3

Genetic Association Database (GAD)
CACNG3
Human Genome Epidemiology (HuGE) Navigator
CACNG3
genes like me logo Genes that share disorders with CACNG3: view

No data available for UniProtKB/Swiss-Prot for CACNG3 Gene

Publications for CACNG3 Gene

  1. Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. (PMID: 10221464) Black J.L. III … Lennon V.A. (Mayo Clin. Proc. 1999) 2 3 4 23
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Linkage and association analysis of CACNG3 in childhood absence epilepsy. (PMID: 17264864) Everett K.V. … Gardiner M. (Eur. J. Hum. Genet. 2007) 3 48
  5. Calcium channel gamma subunits: a functionally diverse protein family. (PMID: 17652770) Chen R.S. … Best P.M. (Cell Biochem. Biophys. 2007) 3

Products for CACNG3 Gene

Sources for CACNG3 Gene

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