Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CACNG3 Gene

protein-coding GIFtS: 60
GCID: GC16P024267

calcium channel, voltage-dependent, gamma subunit 3

Explore 6 diseases affiliated with
CACNG3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 3¹ ²
Neuronal Voltage-Gated Calcium Channel Gamma-3 Subunit² ³
Transmembrane AMPAR Regulatory Protein Gamma-3² ³
TARP Gamma-3² ³
Voltage-Dependent Calcium Channel Gamma-3 Subunit²
Voltage-Gated Calcium Channel Gamma Subunit²

External Ids:	HGNC: 1407¹	Entrez Gene: 10368²	Ensembl: ENSG00000006116⁷	OMIM: 606403⁵	UniProtKB: O60359³

Export aliases for CACNG3 gene to outside databases

Previous GC identifers: GC16P023676 GC16P024366 GC16P024194 GC16P024233 GC16P024174 GC16P022358

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CACNG3:

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both

trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein

subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. (provided

by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: CCG3_HUMAN, O60359

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes

their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of

activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates

all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)

Gene Wiki entry for CACNG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CACNG3 gene promoter:
TBP LHX3b/Lhx3b NRSF form 1 MyoD Nkx2-5 LCR-F1 Tal-1beta NRSF form 2 E47 LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CACNG3 promoter sequence

Search SABiosciences Chromatin IP Primers for CACNG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12.1

CACNG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P024267: view genomic region (about GC identifiers)

Start:	24,266,874 bp from pter	End:	24,374,122 bp from pter
Size:	107,249 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCG3_HUMAN, O60359 (See protein sequence)

Recommended Name: Voltage-dependent calcium channel gamma-3 subunit

Size: 315 amino acids; 35549 Da

Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an

auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,

CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for CACNG3: NX_O60359

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60359

CACNG3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006530.1

ENSEMBL proteins:

ENSP00000005284

Reactome Protein details: O60359
Human Recombinant Protein Products for CACNG3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CACNG3 OriGene Custom Protein Services for CACNG3
	GenScript Custom Purified and Recombinant Proteins Services for CACNG3
	Novus Biologicals CACNG3 Protein Novus Biologicals CACNG3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005891	voltage-gated calcium channel complex	NAS	10221464
GO:0030666	endocytic vesicle membrane	TAS	--
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	ISS	--

CACNG3 for ontologies About GeneDecksing

CACNG3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CACNG3
	GenScript Custom Superior Antibodies Services for CACNG3
	Novus Biologicals CACNG3 Antibodies
	Abcam antibodies for CACNG3
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for CACNG3

Assay Products for CACNG3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CACNG3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CACNG3 for domains About GeneDecksing

2 InterPro domains/families:

IPR008368 VDCC_gsu

IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry O60359

ProtoNet protein and cluster: O60359

1 Blocks protein family: IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CCG3_HUMAN, O60359

Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CCG3_HUMAN, O60359

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes

their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of

activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates

all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)

Genatlas biochemistry entry for CACNG3:

calcium voltage-gated channel (VDCC),L type,dihydropyridine (DPH) sensitive,gamma regulatory subunit 3,neuronal

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005245	voltage-gated calcium channel activity	NAS	10221464

CACNG3 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cacng3):

behavior/neurological	growth/size	homeostasis/metabolism	mortality/aging	nervous system
normal

CACNG3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cacng3^tm1Ran for CACNG3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CACNG3

miRNA Products:		OriGene 3'-UTR Clone: CACNG3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNG3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CACNG3 (see all 15):
		hsa-miR-22 hsa-miR-3173-3p hsa-miR-520f hsa-miR-181c* hsa-miR-1257 hsa-miR-3918 hsa-miR-570 hsa-miR-877*

		SwitchGear 3'UTR luciferase reporter plasmid: CACNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG3 (see all 7) OriGene shRNA RFP: CACNG3 OriGene siRNA: CACNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CACNG3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CACNG3
			Sirion Biotech Customized adenovirus for overexpression of CACNG3 Sirion Biotech Customized adenovirus for potent knockdown of CACNG3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CACNG3 (NM_006539)
		Sino Biological Human cDNA Clone for CACNG3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CACNG3
		Search LifeMap BioReagents cell lines for CACNG3
		Sirion Biotech Customized stable knockdown cell line services for CACNG3 Sirion Biotech Customized inducible knockdown cell line services for CACNG3 Sirion Biotech Customized stable overexpressing cell line services for CACNG3 Sirion Biotech Customized inducible overexpressing cell line services for CACNG3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

DREAM Repression and Dynorphin Expression

DREAM Repression and Dynorphin Expression	1.00	Caspase Cascade	0.24
BMP Pathway	0.44	Calpain Protease Regulates Cellular Mechanics	0.22
nNOS Signaling in Skeletal Muscle	0.37

PKC-Theta Pathway

PKC-Theta Pathway	1.00	Fc-EpsilonRI Pathway	0.42
TCR Signaling	0.68	PDGF Pathway	0.35
ITK and TCR Signaling	0.54

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CACNG3

Transcription CREB pathway

5/37 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNG3 (see all 37)

	Caspase Cascade
	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	PDGF Pathway
	BMP Pathway

1 GeneGo (Thomson Reuters) Pathway for CACNG3

Transcription CREB pathway

1 BioSystems Pathway for CACNG3

Arrhythmogenic right ventricular cardiomyopathy

5 Reactome Pathways for CACNG3

	Trafficking of AMPA receptors
	Transmission across Chemical Synapses
	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

5 Kegg Pathways (Kegg details for CACNG3):

	MAPK signaling pathway
	Cardiac muscle contraction
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathy

CACNG3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CACNG3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/74 Interacting proteins for CACNG3 (O60359³ ENSP00000005284⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP4M1	O00189³, ENSP00000352603⁴	I2D: score=1 STRING: ENSP00000352603
CACNA1D	ENSP00000288139⁴	STRING: ENSP00000288139
CACNA1F	ENSP00000365441⁴	STRING: ENSP00000365441
CACNA2D1	ENSP00000349320⁴	STRING: ENSP00000349320
CACNB3	ENSP00000301050⁴	STRING: ENSP00000301050

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	NAS	10221464
GO:0007268	synaptic transmission	TAS	--
GO:0051925	regulation of calcium ion transport via voltage-gated calcium channel activity	--	--
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	ISS	--

CACNG3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CACNG3

1 HMDB Compound for CACNG3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CACNG3 / CCG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CACNG3 gene:

NM_006539.3

Unigene Cluster for CACNG3:

Calcium channel, voltage-dependent, gamma subunit 3

Hs.7235 [show with all ESTs]

Unigene Representative Sequence: AK095553

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000005284(uc002dmf.3)

miRNA Products:		OriGene 3'-UTR Clone: CACNG3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNG3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CACNG3 (see all 15):
		hsa-miR-22 hsa-miR-3173-3p hsa-miR-520f hsa-miR-181c* hsa-miR-1257 hsa-miR-3918 hsa-miR-570 hsa-miR-877*

		SwitchGear 3'UTR luciferase reporter plasmid: CACNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG3 (see all 7) OriGene shRNA RFP: CACNG3 OriGene siRNA: CACNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CACNG3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CACNG3 (NM_006539)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CACNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG3

Additional cDNA sequence:

AF100346.1 AF114832.1 AF134640.1 AK055453.1 AK095553.1 AK315150.1 BC033741.1 BC037899.1

BC040005.1

2 DOTS entries:

DT.310823 DT.101982910

24/54 AceView cDNA sequences (see all 54):

AF100346 BC037899 CR623650 BX464317 CB153595 AF114832 NM_006539 AF134640

BM672265 BP346488 BC040005 AK095553 BC033741 AK055453 BX280569 BX464363

BI821976 H38292 BP346471 BG705097 BX442586 BI821441 BI546513 BQ186344

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CACNG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATTAAAGG

About this image

CACNG3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CACNG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNG3

SOURCE GeneReport for Unigene cluster: Hs.7235

SABiosciences Custom PCR Arrays for CACNG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CACNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CACNG3 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CACNG3¹	calcium channel, voltage-dependent, gamma subunit 3	79.72(n) 89.81(a)		395378 NM_204660.1 NP_989991.1
zebrafish (Danio rerio)	Actinopterygii	LOC564883¹	voltage-dependent calcium channel gamma-3 subunit-like	73.27(n) 82.14(a)		564883 XM_688207.3 XP_693299.1

ENSEMBL Gene Tree for CACNG3 (if available)
TreeFam Gene Tree for CACNG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CACNG3 gene

CACNG4² CACNG7² CACNG5² CACNG2² CACNG8²

3 SIMAP similar genes for CACNG3 using alignment to 1 protein entry: CCG3_HUMAN:

CACNG2 CACNG4 CACNG8

CACNG3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185596962^1,2		--	24264981(+)	`ACCTTA/CATCTA`	1	--	us2k¹		0	--	--	--	--
rs142438403^1,2		--	24265007(+)	`CTTTTA/CCCCCA`	1	--	us2k¹		0	--	--	--	--
rs150936646^1,2		--	24265073(+)	`GTAGAA/GCTAAG`	1	--	us2k¹		0	--	--	--	--
rs149694593^1,2		--	24265156(+)	`AGCCCA/GAAGCT`	1	--	us2k¹		0	--	--	--	--
rs146706313^1,2		--	24265215(+)	`ACTTCA/TATCCA`	1	--	us2k¹		0	--	--	--	--
rs190512696^1,2		--	24265222(+)	`TCCAAA/GCAAGA`	1	--	us2k¹		0	--	--	--	--
rs193266001^1,2	C	--	24265251(+)	`TGAAAC/TGACTG`	1	--	us2k¹		0	--	--	--	--
rs184232744^1,2		--	24265321(+)	`TTTGCC/TAACTG`	1	--	us2k¹		0	--	--	--	--
rs3760105^1,2	C,F,H	--	24265411(-)	`TCCTGC/TCTTGA`	1	--	us2k¹		31		EA NA NS CSA WA	4618
rs188941052^1,2		--	24265543(+)	`GCTGGC/GCCCAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CACNG3 (24266874 - 24374122 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CACNG3
2 CNVs: 47954 4935

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNG3

DNA2.0 Custom Variant and Variant Library Synthesis for CACNG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CACNG3 for disorders           About GeneDecksing

OMIM gene information: 606403    OMIM disorders: --

6 diseases for CACNG3:    About MalaCards

childhood absence epilepsy absence epilepsy age related macular degeneration macular degeneration

generalized epilepsy neuronitis

2 diseases from the University of Copenhagen DISEASES database for CACNG3:

Juvenile absence epilepsy Idiopathic generalized epilepsy

Human Genome Epidemiology (HuGE) Navigator: CACNG3 (2 documents)

Export disorders for CACNG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CACNG3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CACNG3)

Utopia: connect your pdf to the dynamic
world of online information

Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. (PubMed id 10221464)^{1, 2, 3, 9} Black J.L. III and Lennon V.A. (1999)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2, 3} Loftus B.J.... Adams M.D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration suscept ibility. (PubMed id 21169531)¹ Spencer K.L....Haines J.L. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
TARPs differentially decorate AMPA receptors to speci fy neuropharmacology. (PubMed id 20219255)¹ Kato A.S....Bredt D.S. (2010)
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. (PubMed id 18304745)¹ Sager C....Hollmann M. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Calcium channel gamma subunits: a functionally divers e protein family. (PubMed id 17652770)¹ Chen R.S....Best P.M. (2007)
Linkage and association analysis of CACNG3 in childhood absence epilepsy. (PubMed id 17264864)¹ Everett K.V....Gardiner M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10368	HGNC: 1407	AceView: CACNG3	Ensembl:ENSG00000006116	euGenes: HUgn10368
ECgene: CACNG3	Kegg: 10368	H-InvDB: CACNG3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CACNG3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CACNG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CACNG3 gene:
Search GeneIP for patents involving CACNG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CACNG3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG3
	OriGene Protein Over-expression Lysate for CACNG3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CACNG3		OriGene 3'-UTR Clone for CACNG3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CACNG3		OriGene Custom Protein Services for CACNG3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNG3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNG3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG3

	GenScript Custom Purified and Recombinant Proteins Services for CACNG3		GenScript cDNA clones with any tag delivered in your preferred vector for CACNG3
	GenScript Custom Assay Services for CACNG3		GenScript Custom Superior Antibodies Services for CACNG3
	GenScript Custom overexpressing Cell Line Services for CACNG3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CACNG3 promoter
	Search Chromatin IP Primers for CACNG3
	RT² qPCR Primer Assay in human, mouse, rat CACNG3
	Search GNC Networks for CACNG3
	SABiosciences PCR Arrays including human, mouse, rat CACNG3

Search Tocris compounds for CACNG3

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for CACNG3
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CACNG3 antibodies
	CACNG3 proteins
	CACNG3 lysates

	Antibodies for CACNG3
	See all of Abcam's Antibodies, Kits and Proteins for CACNG3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for CACNG3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG3

	SwitchGear 3'UTR luciferase reporter plasmids for CACNG3
	SwitchGear Promoter luciferase reporter plasmids for CACNG3

Search ThermoFisher Antibodies for CACNG3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CACNG3

Sirion Biotech Customized:

	stable knockdown cell line services for CACNG3
	inducible knockdown cell line services for CACNG3
	design and validation of potent shRNA sequences against CACNG3
	adenovirus for potent knockdown of CACNG3
	adenovirus for overexpression of CACNG3
	stable overexpressing cell line services for CACNG3
	inducible overexpressing cell line services for CACNG3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CACNG3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CACNG3 Gene

calcium channel, voltage-dependent, gamma subunit 3

Aliases
for CACNG3 gene

Summaries
for CACNG3 gene

Genomic Views
for CACNG3 gene

Proteins
for CACNG3 gene

Protein Domains /
Families
for CACNG3 gene

Function
for CACNG3 gene

Pathways & Interactions
for CACNG3 gene

Drugs & Compounds
for CACNG3 gene

Transcripts
for CACNG3 gene

Expression
for CACNG3 gene

Orthologs
for CACNG3 gene

Paralogs
for CACNG3 gene

Genomic Variants
for CACNG3 gene

Disorders / Diseases
for CACNG3 gene

Publications
for CACNG3 gene

External Searches for CACNG3 gene

Genome Databases showing CACNG3 gene

Other Databases showing CACNG3 gene

Specialized Databases showing CACNG3 gene

Intellectual Property
for CACNG3 gene

Products
for CACNG3 gene

View Random Gene

Advanced Search

Export list of displayed genes

CACNG3 Gene

calcium channel, voltage-dependent, gamma subunit 3

Aliasesfor CACNG3 gene

Summariesfor CACNG3 gene

Genomic Viewsfor CACNG3 gene

Proteinsfor CACNG3 gene

Protein Domains /Familiesfor CACNG3 gene

Functionfor CACNG3 gene

Pathways & Interactionsfor CACNG3 gene

Drugs & Compoundsfor CACNG3 gene

Transcriptsfor CACNG3 gene

Expression for CACNG3 gene

Orthologsfor CACNG3 gene

Paralogsfor CACNG3 gene

Genomic Variantsfor CACNG3 gene

Disorders / Diseasesfor CACNG3 gene

Publicationsfor CACNG3 gene

External Searches for CACNG3 gene

Genome Databases showing CACNG3 gene

Other Databases showing CACNG3 gene

Specialized Databases showing CACNG3 gene

Intellectual Propertyfor CACNG3 gene

Productsfor CACNG3 gene

View Random Gene

Aliases
for CACNG3 gene

Summaries
for CACNG3 gene

Genomic Views
for CACNG3 gene

Proteins
for CACNG3 gene

Protein Domains /
Families
for CACNG3 gene

Function
for CACNG3 gene

Pathways & Interactions
for CACNG3 gene

Drugs & Compounds
for CACNG3 gene

Transcripts
for CACNG3 gene

Expression
for CACNG3 gene

Orthologs
for CACNG3 gene

Paralogs
for CACNG3 gene

Genomic Variants
for CACNG3 gene

Disorders / Diseases
for CACNG3 gene

Publications
for CACNG3 gene

Intellectual Property
for CACNG3 gene

Products
for CACNG3 gene