Aliases for CACNG2 Gene
External Ids for CACNG2 Gene
Previous GeneCards Identifiers for CACNG2 Gene
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG2 Gene
CACNG2 (Calcium Channel, Voltage-Dependent, Gamma Subunit 2) is a Protein Coding gene. Diseases associated with CACNG2 include mental retardation, autosomal dominant 10 and autosomal dominant non-syndromic intellectual disability. Among its related pathways are MAPK signaling pathway and Developmental Biology. GO annotations related to this gene include voltage-gated calcium channel activity and ionotropic glutamate receptor binding. An important paralog of this gene is CACNG3.
UniProtKB/Swiss-Prot for CACNG2 Gene
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.