Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CACNG1 Gene

Aliases for CACNG1 Gene

  • Calcium Channel, Voltage-Dependent, Gamma Subunit 1 2 3
  • CACNLG 3 4 6
  • Dihydropyridine-Sensitive L-Type, Skeletal Muscle Calcium Channel Subunit Gamma 3 4
  • Neuronal Dihydropyridine-Sensitive Calcium Channel Gamma Subunit 3
  • Voltage-Dependent Calcium Channel Gamma-1 Subunit 3
  • L-Type Calcium Channel Gamma Polypeptide 3

External Ids for CACNG1 Gene

Previous HGNC Symbols for CACNG1 Gene

  • CACNLG

Previous GeneCards Identifiers for CACNG1 Gene

  • GC17M063362
  • GC17M066427
  • GC17P065458
  • GC17P065590
  • GC17P062471
  • GC17P065040
  • GC17P060429

Summaries for CACNG1 Gene

Entrez Gene Summary for CACNG1 Gene

  • Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

GeneCards Summary for CACNG1 Gene

CACNG1 (Calcium Channel, Voltage-Dependent, Gamma Subunit 1) is a Protein Coding gene. Diseases associated with CACNG1 include malignant hyperthermia susceptibility and arrhythmogenic right ventricular cardiomyopathy. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG6.

UniProtKB/Swiss-Prot for CACNG1 Gene

  • This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex

Gene Wiki entry for CACNG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNG1 Gene

Genomics for CACNG1 Gene

Regulatory Elements for CACNG1 Gene

Genomic Location for CACNG1 Gene

Start:
67,044,536 bp from pter
End:
67,056,797 bp from pter
Size:
12,262 bases
Orientation:
Plus strand

Genomic View for CACNG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNG1 Gene

Proteins for CACNG1 Gene

  • Protein details for CACNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06432-CCG1_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-1 subunit
    Protein Accession:
    Q06432
    Secondary Accessions:
    • B2R9N3
    • Q14D59

    Protein attributes for CACNG1 Gene

    Size:
    222 amino acids
    Molecular mass:
    25028 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma

neXtProt entry for CACNG1 Gene

Proteomics data for CACNG1 Gene at MOPED

Post-translational modifications for CACNG1 Gene

  • Glycosylation at Asn43 and Asn79
  • Modification sites at PhosphoSitePlus

Other Protein References for CACNG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNG1 Gene

Domains for CACNG1 Gene

Gene Families for CACNG1 Gene

HGNC:
  • CACN :Calcium channel subunits

Suggested Antigen Peptide Sequences for CACNG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q06432

UniProtKB/Swiss-Prot:

CCG1_HUMAN :
  • Q06432
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with CACNG1: view

Function for CACNG1 Gene

Molecular function for CACNG1 Gene

GENATLAS Biochemistry:
calcium voltage-gated channel (VDCC),L type,dihydropyridine (DHP) sensitive,gamma regulatory subunit 1,30kDa,also expressed in skeletal muscle
UniProtKB/Swiss-Prot Function:
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex

Gene Ontology (GO) - Molecular Function for CACNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CACNG1: view

Phenotypes for CACNG1 Gene

MGI mutant phenotypes for CACNG1:
inferred from 2 alleles
GenomeRNAi human phenotypes for CACNG1:
genes like me logo Genes that share phenotypes with CACNG1: view

Animal Models for CACNG1 Gene

MGI Knock Outs for CACNG1:

miRNA for CACNG1 Gene

miRTarBase miRNAs that target CACNG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CACNG1 Gene

Localization for CACNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNG1 Gene COMPARTMENTS Subcellular localization image for CACNG1 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CACNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CACNG1: view

Pathways for CACNG1 Gene

genes like me logo Genes that share pathways with CACNG1: view

Interacting Proteins for CACNG1 Gene

Gene Ontology (GO) - Biological Process for CACNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8387489
GO:0006936 muscle contraction TAS 8387489
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0070296 sarcoplasmic reticulum calcium ion transport IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CACNG1: view

Compounds for CACNG1 Gene

(3) HMDB Compounds for CACNG1 Gene

Compound Synonyms Cas Number PubMed IDs
Amlodipine
  • AMVAZ
88150-42-9
Calcium
  • Ca
7440-70-2
Verapamil
  • Akilen
52-53-9

(6) Drugbank Compounds for CACNG1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Diltiazem
42399-41-7 target inhibitor
Fluspirilene
  • Fluspirileno [inn-spanish]
1841-19-6 target inhibitor
Ibutilide
  • Ibutilida [INN-Spanish]
122647-32-9 target activator
Lercanidipine
100427-26-7 target inhibitor
Magnesium Sulfate
  • Bitter salt
7487-88-9 target
genes like me logo Genes that share compounds with CACNG1: view

Transcripts for CACNG1 Gene

mRNA/cDNA for CACNG1 Gene

(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNG1 Gene

Calcium channel, voltage-dependent, gamma subunit 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNG1 Gene

No ASD Table

Relevant External Links for CACNG1 Gene

GeneLoc Exon Structure for
CACNG1
ECgene alternative splicing isoforms for
CACNG1

Expression for CACNG1 Gene

mRNA expression in normal human tissues for CACNG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNG1 Gene

This gene is overexpressed in Muscle - Skeletal (49.8).

Protein differential expression in normal tissues for CACNG1 Gene

This gene is overexpressed in Tonsil (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNG1 Gene

SOURCE GeneReport for Unigene cluster for CACNG1 Gene Hs.147989

mRNA Expression by UniProt/SwissProt for CACNG1 Gene

Q06432-CCG1_HUMAN
Tissue specificity: Skeletal muscle
genes like me logo Genes that share expressions with CACNG1: view

Expression partners for CACNG1 Gene

In Situ Assay Products

Orthologs for CACNG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CACNG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNG1 35
  • 83.63 (n)
  • 81.08 (a)
CACNG1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNG1 35
  • 87.39 (n)
  • 86.49 (a)
CACNG1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacng1 35
  • 80.93 (n)
  • 85.59 (a)
Cacng1 16
Cacng1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNG1 35
  • 99.85 (n)
  • 99.55 (a)
CACNG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacng1 35
  • 81.68 (n)
  • 83.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNG1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNG1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACNG1 35
  • 75.68 (n)
  • 72.97 (a)
CACNG1 36
  • 72 (a)
OneToMany
CACNG1 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CACNG1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacng1 35
  • 71.95 (n)
  • 64.71 (a)
Str.8246 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15784 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5411 35
LOC571193 35
  • 73.15 (n)
  • 71.04 (a)
cacng1 36
  • 65 (a)
OneToMany
CACNG1 (2 of 2) 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8319 35
Species with no ortholog for CACNG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACNG1 Gene

ENSEMBL:
Gene Tree for CACNG1 (if available)
TreeFam:
Gene Tree for CACNG1 (if available)

Paralogs for CACNG1 Gene

Paralogs for CACNG1 Gene

Selected SIMAP similar genes for CACNG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CACNG1: view

Variants for CACNG1 Gene

Sequence variations from dbSNP and Humsavar for CACNG1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs833 -- 67,056,488(+) CCACA(C/G/T)TTGGG utr-variant-3-prime
rs2684 -- 67,056,489(+) CACAG(C/T)TGGGG utr-variant-3-prime
rs1799938 - 67,056,188(+) TCGGC(A/G)GTCTC missense, reference
rs2270084 -- 67,054,189(-) ACCAC(A/G)GGCTT intron-variant
rs2363843 -- 67,049,670(+) TCCAC(C/T)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNG1 Gene

Variant ID Type Subtype PubMed ID
nsv469731 CNV Loss 16826518
nsv9586 CNV Loss 18304495
nsv908690 CNV Loss 21882294

Relevant External Links for CACNG1 Gene

HapMap Linkage Disequilibrium report
CACNG1
Human Gene Mutation Database (HGMD)
CACNG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNG1 Gene

Disorders for CACNG1 Gene

(1) University of Copenhagen DISEASES for CACNG1 Gene

Relevant External Links for CACNG1

Genetic Association Database (GAD)
CACNG1
Human Genome Epidemiology (HuGE) Navigator
CACNG1
genes like me logo Genes that share disorders with CACNG1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CACNG1 Gene

Publications for CACNG1 Gene

  1. Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. (PMID: 8387489) Powers P.A. … Gregg R.G. (J. Biol. Chem. 1993) 3 4 23
  2. Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus. (PMID: 8404045) Iles D.E. … Wieringa B. (Cytogenet. Cell Genet. 1993) 3 4 23
  3. Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. (PMID: 8395940) Iles D.E. … Wieringa B. (Hum. Mol. Genet. 1993) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CACNG1 Gene

Sources for CACNG1 Gene

Back to Top

Content