Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CACNG1 Gene

protein-coding   GIFtS: 59
GCID: GC17P065040

calcium channel, voltage-dependent, gamma subunit 1


(Previous symbol: CACNLG)
 Explore 3 diseases affiliated with
CACNG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CACNG1    

Aliases
for CACNG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium Channel, Voltage-Dependent, Gamma Subunit 11 2
CACNLG1 2 3 5
Dihydropyridine-Sensitive L-Type, Skeletal Muscle Calcium Channel Subunit Gamma2 3
L-Type Calcium Channel Gamma Polypeptide2
Neuronal Dihydropyridine-Sensitive Calcium Channel Gamma Subunit2
Voltage-Dependent Calcium Channel Gamma-1 Subunit2

External Ids:    HGNC: 14051   Entrez Gene: 7862   Ensembl: ENSG000001088787   OMIM: 1142095   UniProtKB: Q064323   

Export aliases for CACNG1 gene to outside databases

Previous GC identifers: GC17M063362 GC17M066427 GC17P065458 GC17P065590 GC17P062471 GC17P060429


Summaries
for CACNG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CACNG1:
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of
these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of
skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role
in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the
PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA
receptor regulatory proteins (TARPs). (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: CCG1_HUMAN, Q06432
Function: This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in
excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple
subunit complex

Gene Wiki entry for CACNG1


Genomic Views
for CACNG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CACNG1 gene promoter:
         AML1a   SREBP-1c   RORalpha2   SREBP-1b   PPAR-alpha   Egr-2   RORalpha1   MZF-1   SREBP-1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CACNG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CACNG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24

CACNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P065040:  view genomic region     (about GC identifiers)

Start:
 65,040,706 bp from pter      End:
 65,052,913 bp from pter
Size:
 12,208 bases      Orientation:
 plus strand

Proteins
for CACNG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCG1_HUMAN, Q06432 (See protein sequence)
Recommended Name: Voltage-dependent calcium channel gamma-1 subunit  
Size: 222 amino acids; 25028 Da
Subunit: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R9N3 Q14D59

Explore the universe of human proteins at neXtProt for CACNG1: NX_Q06432

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06432

    • CACNG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000718.1  
    ENSEMBL proteins: 
     ENSP00000226021  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CACNG1 
    GenScript Custom Purified and Recombinant Proteins Services for CACNG1
    Novus Biologicals CACNG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005891voltage-gated calcium channel complex IEA--


    CACNG1 for ontologies           About GeneDecksing



    CACNG1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CACNG1 
    GenScript Custom Superior Antibodies Services for CACNG1
    Novus Biologicals CACNG1 Antibodies
    Search for Antibodies for CACNG1 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for CACNG1

    Assay Products for CACNG1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CACNG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CACNG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CACNG1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008368 VDCC_gsu
     IPR005421 VDCC_g1su

    Graphical View of Domain Structure for InterPro Entry Q06432

    ProtoNet protein and cluster: Q06432

    1 Blocks protein family: IPB005421 Voltage-dependent calcium channel gamma-1 subunit signature

    UniProtKB/Swiss-Prot: CCG1_HUMAN, Q06432
    Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily


    Function
    for CACNG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCG1_HUMAN, Q06432
    Function: This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in
    excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple
    subunit complex

         Genatlas biochemistry entry for CACNG1:
    calcium voltage-gated channel (VDCC),L type,dihydropyridine (DHP) sensitive,gamma regulatory subunit 1,30kDa,also
    expressed in skeletal muscle

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNG1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CACNG1:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: CACNG1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG1 (see all 7)
    OriGene shRNA RFP: CACNG1
    OriGene siRNA: CACNG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CACNG1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CACNG1 (NM_000727)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CACNG1
    Search LifeMap BioReagents cell lines for CACNG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005245voltage-gated calcium channel activity IEA--


    CACNG1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CACNG1:
     Decreased Hepatitis C virus re  Decreased Tat-dependent transc 

    Animal Models:
         Mouse knock-outs for CACNG1: Cacng1tm1Vfz Cacng1tm1Rgg
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Cacng1):
     muscle 

    CACNG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CACNG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DREAM Repression and Dynorphin Expression
    		DREAM Repression and Dynorphin Expression1.00
    		Caspase Cascade0.24
    		BMP Pathway0.44
    		Calpain Protease Regulates Cellular Mechanics0.22
    		nNOS Signaling in Skeletal Muscle0.37
    2PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		Fc-EpsilonRI Pathway0.42
    		TCR Signaling0.68
    		PDGF Pathway0.35
    		ITK and TCR Signaling0.54
    3Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Cellular Effects of Sildenafil0.46
    		Melatonin Signaling0.72
    4Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    5NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    		IGF1R Signaling0.37
    		Signaling Involved in Cardiac Hypertrophy0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CACNG1
        Transcription CREB pathway

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNG1 (see all 38)
        Caspase Cascade
    Fc-GammaR Pathway
    Intracellular Calcium Signaling
    PDGF Pathway
    BMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for CACNG1
        Transcription CREB pathway

    1 BioSystems Pathway for CACNG1 
        Arrhythmogenic right ventricular cardiomyopathy


    5         Kegg Pathways  (Kegg details for CACNG1):
        MAPK signaling pathway
    Cardiac muscle contraction
    Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy


    CACNG1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for CACNG1 (ENSP000002260214) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKXENSP000002628484STRING: ENSP00000262848
    RASGRF1ENSP000004059634STRING: ENSP00000405963
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8387489
    GO:0006936muscle contraction TAS8387489
    GO:0051925regulation of calcium ion transport via voltage-gated calcium channel activity ----


    CACNG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CACNG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CACNG1

    3 HMDB Compounds for CACNG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmlodipineAMVAZ (see all 7)88150-42-9--
    CalciumCa (see all 2)7440-70-2--
    VerapamilAkilen (see all 107)52-53-9--

    6 DrugBank Compounds for CACNG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Diltiazem-- 42399-41-7targetinhibitor15320693 19929811 17139284 17016423
    Lercanidipine-- 100427-26-7targetinhibitor17139284 17016423 19619074
    FluspirileneFluspirileno [inn-spanish] (see all 2)1841-19-6targetinhibitor1696149 11842444
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetactivator15926871 9257085
    Magnesium SulfateBitter salt (see all 6)7487-88-9target--17139284 17016423
    NitrendipineNitrendipin (see all 3)39562-70-4targetinhibitor17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CACNG1 / CCG1 

    Transcripts
    for CACNG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CACNG1 gene: 
    NM_000727.3  

    Unigene Cluster for CACNG1:

    Calcium channel, voltage-dependent, gamma subunit 1
    Hs.147989  [show with all ESTs]
    Unigene Representative Sequence: NM_000727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226021(uc002jfu.3)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNG1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CACNG1:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: CACNG1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG1 (see all 7)
    OriGene shRNA RFP: CACNG1
    OriGene siRNA: CACNG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CACNG1 (NM_000727)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG1

    Additional cDNA sequence: 

    AF086300.1 AK313852.1 BC069493.1 BC113486.1 BC113492.1 L07738.1 

    1 DOTS entry:

    DT.109799 

    14 AceView cDNA sequences:

    AW949442 NM_000727 BC069493 AA581774 BX109908 W73406 AW206690 AF086300 
    W73801 T28207 L07738 AA452006 AU099627 F18308 

    GeneLoc Exon Structure


    Expression
    for CACNG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CACNG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGCTGAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CACNG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbHindlimb Ventral MuscleLimb
    Skeletal MuscleMandibular Arch MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CACNG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CACNG1

    SOURCE GeneReport for Unigene cluster: Hs.147989

    UniProtKB/Swiss-Prot: CCG1_HUMAN, Q06432
    Tissue specificity: Skeletal muscle

        SABiosciences Custom PCR Arrays for CACNG1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNG1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG1

    Orthologs
    for CACNG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CACNG1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CACNG11 calcium channel, voltage-dependent, gamma subunit 1 75.53(n)
    72.97(a)    		   417428  XM_003642347.1  XP_003642395.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CACNG16
    		 --
    		 56(a)
    		 1 ↔ 1
    		 GL343250.1(364170-402454)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.157842 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    BJ060662.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.54112 Danio rerio mRNA similar to calcium channel, voltage-dependent, more 72.75(n)    BC044150.1 


    ENSEMBL Gene Tree for CACNG1 (if available)
    TreeFam Gene Tree for CACNG1 (if available) 

    Paralogs
    for CACNG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CACNG1 gene
    CACNG62  
    1 SIMAP similar gene for CACNG1 using alignment to 1 protein entry:     CCG1_HUMAN:
    CACNG6

    CACNG1 for paralogs           About GeneDecksing



    Genomic Variants
    for CACNG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/303 NCBI SNPs in CACNG1 are shown (see all 303)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1462591211,2
    		--65038706(+) GGCCCC/TCACAA 1 -- us2k10--------
    rs37602581,2
    		H--65038789(-) TGTCAC/TCAGGT 1 -- us2k15Minor allele frequency- T:0.00EA NS 1894
    rs1380997331,2
    		--65038875(+) GATTAA/GCACCC 1 -- us2k10--------
    rs1495015531,2
    		--65039043(+) GATGCA/GAGGGT 1 -- us2k10--------
    rs1924587791,2
    		--65039059(+) TCAGCC/TCTGGG 1 -- us2k10--------
    rs739973271,2
    		C,--65039139(+) AGATCA/TTGAAG 1 -- us2k14Minor allele frequency- T:0.48WA CSA 122
    rs1440238141,2
    		--65039443(+) AGGCCA/GAAACA 1 -- us2k10--------
    rs1855315231,2
    		--65039523(+) CCCACA/CCAGCT 1 -- us2k10--------
    rs1486764741,2
    		--65039552(+) CATGCA/GTCAGC 1 -- us2k10--------
    rs1473810321,2
    		--65039705(+) CCGGGA/CTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CACNG1 (65040706 - 65052913 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CACNG1
         1 CNV: 2232
         1 Indel: 33654

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNG1
    DNA2.0 Custom Variant and Variant Library Synthesis for CACNG1

    Disorders / Diseases
    for CACNG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CACNG1 for disorders           About GeneDecksing

    OMIM gene information: 114209    OMIM disorders: --

    3 diseases for CACNG1:    About MalaCards
    malignant hyperthermia    malignant hyperthermia susceptibility    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CACNG1:
    Malignant hyperthermia
    Human Genome Epidemiology (HuGE) Navigator: CACNG1 (1 document)

    Export disorders for CACNG1 gene to outside databases

    Publications
    for CACNG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CACNG1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CACNG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus. (PubMed id 8404045)1, 2, 9 Iles D.E.... Wieringa B. (1993)
    2. Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. (PubMed id 8387489)1, 2, 9 Powers P.A.... Gregg R.G. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. (PubMed id 8395940)1, 3 Iles D.E.... Wieringa B. (1993)
    5. Treatment of essential hypertension with calcium chan nel blockers: what is the place of lercanidipine? (PubMed id 19619074)7 Burnier M....Wuerzner G. (2009)
    6. Ligands of diltiazem binding site: an overview of som e chemotypes. (PubMed id 19929811)7 Budriesi R....Chiarini A. (2009)
    7. Calcium channel gamma subunits: a functionally divers e protein family. (PubMed id 17652770)1 Chen R.S....Best P.M. (2007)
    8. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

    External Searches for CACNG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CACNG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 786 HGNC: 1405 AceView: CACNG1 Ensembl:ENSG00000108878 euGenes: HUgn786
    ECgene: CACNG1 Kegg: 786 H-InvDB: CACNG1

    Other Databases showing CACNG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CACNG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CACNG1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CACNG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CACNG1 gene:
    Search GeneIP for patents involving CACNG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CACNG1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CACNG1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNG1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNG1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CACNG1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNG1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CACNG1   OriGene Custom Protein Services for CACNG1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNG1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNG1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNG1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNG1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNG1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNG1
     GenScript Custom Purified and Recombinant Proteins Services for CACNG1 GenScript cDNA clones with any tag delivered in your preferred vector for CACNG1
     GenScript Custom Assay Services for CACNG1 GenScript Custom Superior Antibodies Services for CACNG1
     GenScript Custom overexpressing Cell Line Services for CACNG1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CACNG1 promoter
     Search Chromatin IP Primers for CACNG1
     RT2 qPCR Primer Assay in human, mouse, rat CACNG1
     Search GNC Networks for CACNG1
     SABiosciences PCR Arrays including human, mouse, rat CACNG1
     Search Tocris compounds for CACNG1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CACNG1 antibodies
     CACNG1 lysates
     Search for Antibodies for CACNG1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CACNG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CACNG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNG1
     SwitchGear 3'UTR luciferase reporter plasmids for CACNG1
     SwitchGear Promoter luciferase reporter plasmids for CACNG1
     Search ThermoFisher Antibodies for CACNG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNG1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CACNG1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4