CACNB4 Gene
protein-coding GIFtS: 65
GCID: GC02M152659
|
|
calcium channel, voltage-dependent, beta 4 subunit
| |
Aliases
for CACNB4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Channel, Voltage-Dependent, Beta 4 Subunit1 2 | | EIG92 5 | | EJM41 2 | | EJM62 5 | | Calcium Channel Voltage-Dependent Subunit Beta 42 3 | | EJM2 | | CAB42 3 | | Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-4 Subunit2 | | CACNLB42 3 | | Voltage-Dependent L-Type Calcium Channel Subunit Beta-42 | | EA52 5 | | |
Export aliases for CACNB4 gene to outside databasesPrevious GC identifers: GC02M150446 GC02M151224 GC02M152897 GC02M152520 GC02M152402 GC02M144575 |
Summaries
for CACNB4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CACNB4:
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calciumchannels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex ofalpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist,either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays animportant role in calcium channel function by modulating G protein inhibition, increasing peak calcium current,controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonicepilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Mar 2009)
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel byincreasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating Gprotein inhibition and controlling the alpha-1 subunit membrane targeting
Gene Wiki entry for CACNB4
|
Genomic Views
for CACNB4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CACNB4 gene promoter:
c-Fos AP-1 Tal-1beta YY1 POU2F1 POU2F1b POU2F1a c-Jun MRF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CACNB4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNB4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q22-q23 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q22-q23CACNB4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M152659: view genomic region
(about GC identifiers)
Start:
|
152,689,285 bp from pter |
End:
|
152,955,593 bp from pter |
Size:
|
266,309 bases |
Orientation:
|
minus strand |
|
Proteins
for CACNB4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305 (See
protein sequence)Recommended Name: Voltage-dependent L-type calcium channel subunit beta-4 Size: 520 amino acids; 58169 Da
Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts withFASLG
2 PDB 3D structures from  and Proteopedia  for CACNB4:1VYV (3D)
2D46 (3D)
Secondary accessions: A7BJ74 A8K1Y4 B4DG40 O60515 Q6B000 Q96L40Alternative splicing: 4 isoforms: O00305-1 O00305-2 O00305-3 O00305-4 (Unable to interact with the alpha-1 subunit)Explore the universe of human proteins at neXtProt for CACNB4: NX_O00305
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00305
CACNB4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_000717.2 NP_001005746.1 NP_001005747.1 NP_001139270.1
ENSEMBL proteins: ENSP00000438949 ENSP00000390161 ENSP00000443893 ENSP00000380490 ENSP00000410978 ENSP00000201943 ENSP00000399242 ENSP00000343563 ENSP00000353425 Reactome Protein details: O00305
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CACNB4 for ontologies About GeneDecksing
CACNB4 Antibody Products:
Assay Products for CACNB4: |
Protein
Domains /
Families
for CACNB4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CACNB4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00305ProtoNet protein and cluster: O00305 2 Blocks protein families: IPB000584 L-type calcium channel beta subunit signature IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305Similarity: Belongs to the calcium channel beta subunit familySimilarity: Contains 1 SH3 domain |
Function
for CACNB4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel byincreasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating Gprotein inhibition and controlling the alpha-1 subunit membrane targeting Genatlas biochemistry entry for CACNB4:calcium voltage-gated channel (VDCC) beta 4 regulatory subunit,55kDa,expressed inbrain,cerebellum,kidney,testis,retina,lymphoblasts and circulating lymphocytes,ortholog of the mouse epilepsy genelethargic
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): CACNB4 (NM_000726) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNB4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CACNB4 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CACNB4:
Animal Models:
13 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Cacnb4):
CACNB4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CACNB4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DREAM Repression and Dynorphin Expression | | | 2 | PKC-Theta Pathway | | | 3 | Sweet Taste Signaling | | | 4 | Activation of cAMP-Dependent PKA | | | 5 | NFAT and Cardiac Hypertrophy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CACNB4
5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNB4 (see all 38)
1  GeneGo (Thomson Reuters) Pathway for CACNB4
1  BioSystems Pathway for CACNB4
5/7 
Reactome Pathways for CACNB4 (see all 7)
1  PharmGKB Pathway for CACNB4
5 
Kegg Pathways (Kegg details for CACNB4):
CACNB4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNB4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/59 Interacting proteins for CACNB4 (O003051, 2, 3 ENSP000003435634) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table
CACNB4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CACNB4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CACNB4 for compounds About GeneDecksing
 Browse Tocris compounds for CACNB4
2 HMDB Compounds for CACNB4 About this table
3 DrugBank Compounds for CACNB4 About this table
1 Novoseek chemical compound relationship for CACNB4 gene About this table
Search CenterWatch for drugs/clinical trials and news about CACNB4 / CACB4
|
Transcripts
for CACNB4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CACNB4 gene (4 alternative transcripts): NM_000726.3 NM_001005746.2 NM_001005747.2 NM_001145798.1 Unigene Cluster for CACNB4: Calcium channel, voltage-dependent, beta 4 subunit Hs.120725 [show with all ESTs]Unigene Representative Sequence: NM_00100574711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539935(uc002txz.3 uc002tya.3 uc010fnz.3) ENST00000439467
ENST00000534999 ENST00000397327 ENST00000427385 ENST00000201943 ENST00000470066(uc002tyb.2)
ENST00000434468 ENST00000475848 ENST00000339254 ENST00000360283(uc002txy.3 uc021vre.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): CACNB4 (NM_000726) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNB4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB4 |
Additional cDNA sequence: AB302276.1 AF038852.1 AF075047.1 AK290049.1 AK291378.1 AK294398.1 AK316045.1 AY054985.1 BC075049.2 HQ214056.1 U95020.1 6 DOTS entries: DT.407311 DT.205304 DT.75164259 DT.120946835 DT.120946845 DT.91651650 14 AceView cDNA sequences: BX279713 NM_000726 AF038852 AL700210 BX484858 BC075049 AW134825 U95020 BP360802 AY054985 BE856737 BX648679 R41472 R15034
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CACNB4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CACNB4
|
Expression
for CACNB4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CACNB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CACNB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNB4
SOURCE GeneReport for Unigene cluster: Hs.120725
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305Tissue specificity: Expressed predominantly in the cerebellum and kidney
SABiosciences Custom PCR Arrays for CACNB4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNB4
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB4 |
Orthologs
for CACNB4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CACNB4 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CACNB41 |
calcium channel, voltage-dependent, beta 4 subunit |
85.28(n)
99.22(a) |
|
374259 NM_001001733.1 NP_001001733.1 |
lizard
(Anolis carolinensis) |
Reptilia |
B6IDG1_ANOCA6 |
Voltage-gated calcium channel beta 4 subunit trans... |
98(a) |
1 ↔ 1 |
GL343296.1(1391145-1607105) |
zebrafish
(Danio rerio) |
Actinopterygii |
cacnb4a1 |
calcium channel, voltage-dependent, beta 4a subunit |
75.74(n)
87.64(a) |
|
562422 NM_001113519.1 NP_001106991.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ca-&bgr;3 |
calcium ion transport voltage-gated calcium
channel |
65(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ccb-13 |
calcium channel subunit |
63(a)
(best of 2) |
|
I(3641606-3646883) -- |
ENSEMBL Gene Tree for CACNB4 (if available)
TreeFam Gene Tree for CACNB4 (if available) |
Paralogs
for CACNB4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CACNB4 gene
- CACNB12 CACNB32 CACNB22
3 SIMAP similar genes for CACNB4 using alignment to 9 protein entries: CACB4_HUMAN (see all proteins):CACNB1 CACNB3 CACNB2
CACNB4 for paralogs About GeneDecksing
|
Genomic Variants
for CACNB4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CACNB4 (152689285 - 152939285 bp, first 250kb of CACNB4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CACNB4
4 CNVs: 98017 90079 90083 8961
2 Indels: 45878 41388
Human Gene Mutation Database (HGMD): CACNB4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNB4 |
|
Disorders
/ Diseases
for CACNB4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CACNB4 for disorders About GeneDecksing
OMIM gene information: 601949
OMIM disorders: 607682
UniProtKB/Swiss-Prot: CACB4_HUMAN, O00305
Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9)[MIM:607682]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesionsand/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of thebrain Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682].EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence(rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleepdeprivation and fatigue Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5) [MIM:613855]. EA5 is a disorder characterizedby episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat andgaze-evoked nystagmus, mild dysarthria and truncal ataxia
15  diseases for CACNB4: About MalaCardsjuvenile myoclonic epilepsy idiopathic generalized epilepsy generalized epilepsy episodic ataxia, type 5 (3) 2
episodic ataxia type 5 episodic ataxia episodic ataxia type 2 febrile convulsions
convulsions ataxia nystagmus neurologic diseases
migraine obesity neuronitis
1 disease from the University of Copenhagen DISEASES database for CACNB4:Episodic ataxia 1 Novoseek disease relationship for CACNB4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| epilepsy |
37.9 |
2 |
11305685 (1), 9628818 (1) |
GeneTests: CACNB4
Episodic Ataxia Type 2
Human Genome Epidemiology (HuGE) Navigator: CACNB4 (3 documents)
Export disorders for CACNB4 gene to outside databases
|
Publications
for CACNB4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CACNB4 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with CACNB4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Calcium channel beta4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. (PubMed id 9628818)1, 2, 3, 9 Escayg A.... Meisler M.H. (1998)
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
- The GK domain of the voltage-dependent calcium channel beta subunit is essential for binding to the alpha subunit. (PubMed id 17618603)1, 2 Kobayashi T.... Tohse N. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Alternative splicing of the beta 4 subunit has alpha 1 subunit subtype-specific effects on Ca2+ channel gating. (PubMed id 11880487)1, 2 Helton T.D. and Horne W.A. (2002)
- Coding and noncoding variation of the human calcium-channel beta4- subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. (PubMed id 10762541)1, 2 Escayg A.... Meisler M.H. (2000)
- Assignment of human genes for beta 2 and beta 4 subunits of voltage- dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. (PubMed id 9254841)1, 2 Taviaux S.... Lory P. (1997)
- Cacnb4 directly couples electrical activity to gene ex pression, a process defective in juvenile epilepsy. (PubMed id 22892567)1 Tadmouri A....De Waard M. (2012)
- The Ca2+ channel beta4c subunit interacts with hetero chromatin protein 1 via a PXVXL binding motif. (PubMed id 21220418)1 Xu X....Horne W.A. (2011)
- Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. (PubMed id 21297076)1 Leikauf G.D....Prows D.R. (2011)
|
External Searches for CACNB4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CACNB4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CACNB4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CACNB4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CACNB4 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CACNB4 |
|
| | |
About This Section
| Patent Information for CACNB4 gene:
Search GeneIP for patents involving CACNB4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CACNB4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CACNB4 | | OriGene shRNA RFP for CACNB4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNB4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNB4 | | | OriGene Protein Over-expression Lysate for CACNB4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CACNB4 | | OriGene 3'-UTR Clone for CACNB4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CACNB4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CACNB4 | | OriGene Custom Protein Services for CACNB4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNB4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNB4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNB4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNB4 |
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| | | | Search Tocris compounds for CACNB4 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB4 |
|  |  |  | | | | ThermoFisher Antibodies for CACNB4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB4 |
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