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Aliases for CACNB3 Gene

Aliases for CACNB3 Gene

  • Calcium Channel, Voltage-Dependent, Beta 3 Subunit 2 3
  • CACNLB3 3 4
  • CAB3 3 4
  • Voltage-Dependent L-Type Calcium Channel Subunit Beta-3 3
  • Calcium Channel Voltage-Dependent Subunit Beta 3 4

External Ids for CACNB3 Gene

Previous HGNC Symbols for CACNB3 Gene

  • CACNLB3

Previous GeneCards Identifiers for CACNB3 Gene

  • GC12M049140
  • GC12M049209
  • GC12P048924
  • GC12P047498
  • GC12P049212
  • GC12P046245

Summaries for CACNB3 Gene

Entrez Gene Summary for CACNB3 Gene

  • This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

GeneCards Summary for CACNB3 Gene

CACNB3 (Calcium Channel, Voltage-Dependent, Beta 3 Subunit) is a Protein Coding gene. Diseases associated with CACNB3 include canavan disease and arrhythmogenic right ventricular cardiomyopathy. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNB4.

UniProtKB/Swiss-Prot for CACNB3 Gene

  • The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting

Gene Wiki entry for CACNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNB3 Gene

Genomics for CACNB3 Gene

Regulatory Elements for CACNB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACNB3 Gene

Start:
48,813,794 bp from pter
End:
48,828,943 bp from pter
Size:
15,150 bases
Orientation:
Plus strand

Genomic View for CACNB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNB3 Gene

Proteins for CACNB3 Gene

  • Protein details for CACNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54284-CACB3_HUMAN
    Recommended name:
    Voltage-dependent L-type calcium channel subunit beta-3
    Protein Accession:
    P54284
    Secondary Accessions:
    • A8K0Z4
    • B7Z4Q1
    • B7Z973
    • B7ZAK8
    • F5GZW7
    • F5H2P6
    • F8VSG3
    • Q13913

    Protein attributes for CACNB3 Gene

    Size:
    484 amino acids
    Molecular mass:
    54532 Da
    Quaternary structure:
    • The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG.

    Alternative splice isoforms for CACNB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNB3 Gene

Proteomics data for CACNB3 Gene at MOPED

Post-translational modifications for CACNB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CACNB3 Gene

Domains for CACNB3 Gene

Gene Families for CACNB3 Gene

HGNC:
  • CACN :Calcium channel subunits

Suggested Antigen Peptide Sequences for CACNB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54284

UniProtKB/Swiss-Prot:

CACB3_HUMAN :
  • P54284
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the calcium channel beta subunit family.
genes like me logo Genes that share domains with CACNB3: view

Function for CACNB3 Gene

Molecular function for CACNB3 Gene

GENATLAS Biochemistry:
calcium voltage-gated channel (VDCC),L type,dihydropyridine (DHP) sensitive,beta 3 regulatory subunit,55kDa,expressed in brain,smooth muscle,ovary
UniProtKB/Swiss-Prot Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting

Gene Ontology (GO) - Molecular Function for CACNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 contributes_to voltage-gated calcium channel activity IDA 11160515
GO:0005515 protein binding --
GO:0008331 high voltage-gated calcium channel activity IBA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CACNB3: view
genes like me logo Genes that share phenotypes with CACNB3: view

Animal Models for CACNB3 Gene

MGI Knock Outs for CACNB3:

miRNA for CACNB3 Gene

miRTarBase miRNAs that target CACNB3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CACNB3 Gene

Localization for CACNB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNB3 Gene COMPARTMENTS Subcellular localization image for CACNB3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CACNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005891 voltage-gated calcium channel complex IDA 11160515
GO:0016020 membrane IDA 16525042
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with CACNB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CACNB3 Gene

Pathways for CACNB3 Gene

genes like me logo Genes that share pathways with CACNB3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CACNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8119293
GO:0006816 calcium ion transport IDA 11160515
GO:0007268 synaptic transmission TAS --
GO:0007411 axon guidance TAS --
GO:0007528 neuromuscular junction development IBA --
genes like me logo Genes that share ontologies with CACNB3: view

Compounds for CACNB3 Gene

(2) HMDB Compounds for CACNB3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Verapamil
  • Akilen
52-53-9

(4) Drugbank Compounds for CACNB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dronedarone
141626-36-0 target
Mibefradil
116644-53-2 target inhibitor
Nimodipine
  • Nimodipino [INN-Spanish]
66085-59-4 target inhibitor
Verapamil
  • Verapamil [Usan:Ban:Inn]
52-53-9 target inhibitor
genes like me logo Genes that share compounds with CACNB3: view

Transcripts for CACNB3 Gene

mRNA/cDNA for CACNB3 Gene

Unigene Clusters for CACNB3 Gene

Calcium channel, voltage-dependent, beta 3 subunit:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNB3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNB3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - -
SP10:
SP11: - - -
SP12: - -
SP13: - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CACNB3 Gene

GeneLoc Exon Structure for
CACNB3
ECgene alternative splicing isoforms for
CACNB3

Expression for CACNB3 Gene

mRNA expression in normal human tissues for CACNB3 Gene

Protein differential expression in normal tissues for CACNB3 Gene

This gene is overexpressed in Brain (35.1), Heart (11.3), Frontal cortex (10.8), and Ovary (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACNB3 Gene

SOURCE GeneReport for Unigene cluster for CACNB3 Gene Hs.250712

mRNA Expression by UniProt/SwissProt for CACNB3 Gene

P54284-CACB3_HUMAN
Tissue specificity: Expressed mostly in brain, smooth muscle and ovary
genes like me logo Genes that share expressions with CACNB3: view

Expression partners for CACNB3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CACNB3 Gene

Orthologs for CACNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNB3 35
  • 94.04 (n)
  • 98.11 (a)
CACNB3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNB3 35
  • 94.17 (n)
  • 98.29 (a)
CACNB3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacnb3 35
  • 93.65 (n)
  • 99.17 (a)
Cacnb3 16
Cacnb3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNB3 35
  • 99.79 (n)
  • 99.59 (a)
CACNB3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacnb3 35
  • 92.84 (n)
  • 98.74 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNB3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNB3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNB3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacnb3 35
  • 76.44 (n)
  • 85.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia cacnb3-A 35
zebrafish
(Danio rerio)
Actinopterygii cacnb3b 35
  • 74.77 (n)
  • 83.33 (a)
cacnb3a 36
  • 70 (a)
OneToMany
cacnb3b 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ca-bgr 37
  • 61 (a)
Ca-beta 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccb-1 37
  • 60 (a)
W10C8.1 37
  • 28 (a)
ccb-1 36
  • 47 (a)
OneToMany
Species with no ortholog for CACNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACNB3 Gene

ENSEMBL:
Gene Tree for CACNB3 (if available)
TreeFam:
Gene Tree for CACNB3 (if available)

Paralogs for CACNB3 Gene

Paralogs for CACNB3 Gene

genes like me logo Genes that share paralogs with CACNB3: view

Variants for CACNB3 Gene

Sequence variations from dbSNP and Humsavar for CACNB3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs954 -- 48,828,434(+) CCATC(C/T)GTTTG utr-variant-3-prime
rs1045328 -- 48,818,948(+) CCTAC(C/G)TGCCC missense, reference, intron-variant, upstream-variant-2KB
rs1045336 -- 48,827,731(+) GACTA(C/T)GCAGA synonymous-codon, reference
rs1045340 -- 48,827,839(+) TCAGA(A/G)CACAA synonymous-codon, reference
rs1045356 -- 48,828,825(+) GCACA(A/G)AGGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CACNB3 Gene

Variant ID Type Subtype PubMed ID
nsv826363 CNV Gain 20364138
nsv698 CNV Insertion 18451855

Relevant External Links for CACNB3 Gene

HapMap Linkage Disequilibrium report
CACNB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNB3 Gene

Disorders for CACNB3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CACNB3 Gene in MalaCards »

(2) Diseases for CACNB3 Gene including...

(1) University of Copenhagen DISEASES for CACNB3 Gene

Relevant External Links for CACNB3

Genetic Association Database (GAD)
CACNB3
genes like me logo Genes that share disorders with CACNB3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CACNB3 Gene

Publications for CACNB3 Gene

  1. Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit. (PMID: 8119293) Collin T. … Nargeot J. (Eur. J. Biochem. 1994) 2 3 4 23
  2. Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. (PMID: 12181424) Qin N. … D'Andrea M.R. (Mol. Pharmacol. 2002) 3 4
  3. The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. (PMID: 7557998) Yamada Y. … Seino Y. (Genomics 1995) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CACNB3 Gene

Sources for CACNB3 Gene

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