CACNB1 Gene
protein-coding GIFtS: 62
GCID: GC17M037329
|
|
calcium channel, voltage-dependent, beta 1 subunit
(Previous symbol: CACNLB1)
| |
Aliases
for CACNB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Channel, Voltage-Dependent, Beta 1 Subunit1 2 | | CCHLB12 5 | | CACNLB11 2 3 5 | | Calcium Channel, L Type, Beta 1 Polypeptide2 | | Calcium Channel Voltage-Dependent Subunit Beta 12 3 | | Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-1 Subunit2 | | CAB12 3 | | Voltage-Dependent L-Type Calcium Channel Subunit Beta-12 |
Export aliases for CACNB1 gene to outside databasesPrevious GC identifers: GC17M036833 GC17M039327 GC17M037240 GC17M037704 GC17M034583 GC17M033125 |
Summaries
for CACNB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CACNB1:
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in thecalcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunitmembrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs atthis locus and three transcript variants encoding three distinct isoforms have been identified. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: CACB1_HUMAN, Q02641Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel byincreasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating Gprotein inhibition and controlling the alpha-1 subunit membrane targeting
Gene Wiki entry for CACNB1
|
Genomic Views
for CACNB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CACNB1 gene promoter:
c-Fos RFX1 AP-1 POU2F1 POU2F1a c-Myb Nkx2-5 MRF-2 LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CACNB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21-q22 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21-q22CACNB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037329: view genomic region
(about GC identifiers)
Start:
|
37,329,709 bp from pter |
End:
|
37,353,956 bp from pter |
Size:
|
24,248 bases |
Orientation:
|
minus strand |
|
Proteins
for CACNB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CACB1_HUMAN, Q02641 (See
protein sequence)Recommended Name: Voltage-dependent L-type calcium channel subunit beta-1 Size: 598 amino acids; 65714 Da
Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts withJSRP1. Interacts with RYR1 (By similarity)
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side
Sequence caution: Sequence=CAA79825.1; Type=Erroneous initiation;
Secondary accessions: A8K114 O15331 Q02639 Q02640 Q8N3X9 Q9C085 Q9UD79Alternative splicing: 3 isoforms: Q02641-1 Q02641-2 Q02641-3 Explore the universe of human proteins at neXtProt for CACNB1: NX_Q02641
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02641
CACNB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000714.3 NP_954855.1 NP_954856.1
ENSEMBL proteins: ENSP00000377840 ENSP00000377847 ENSP00000345461 Reactome Protein details: Q02641
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005891 | voltage-gated calcium channel complex |
IEA | -- | | GO:0016529 | sarcoplasmic reticulum |
IEA | -- | | GO:0030315 | T-tubule |
IEA | -- |
CACNB1 for ontologies About GeneDecksing
CACNB1 Antibody Products:
Assay Products for CACNB1: |
Protein
Domains /
Families
for CACNB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CACNB1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02641ProtoNet protein and cluster: Q02641 2 Blocks protein families: IPB000584 L-type calcium channel beta subunit signature IPB005443 L-type calcium channel beta-1 subunit signature
UniProtKB/Swiss-Prot: CACB1_HUMAN, Q02641Similarity: Belongs to the calcium channel beta subunit familySimilarity: Contains 1 SH3 domain |
Function
for CACNB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CACB1_HUMAN, Q02641Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel byincreasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating Gprotein inhibition and controlling the alpha-1 subunit membrane targeting Genatlas biochemistry entry for CACNB1:transverse tubule (TT) calcium voltage-gated channel (VDCC),L (long lasting) type,dihydropyridine (DHP) sensitive,beta1 regulatory subunit,expressed in skeletal muscle,heart and brain isoforms,with CAG repeat
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CACNB1 (NM_199248) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005245 | voltage-gated calcium channel activity |
TAS | 1385409 | | GO:0005515 | protein binding |
-- | -- | | GO:0008331 | high voltage-gated calcium channel activity |
IEA | -- |
CACNB1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CACNB1:
Animal Models:
Mouse knock-out Cacnb1tm1Rgg for CACNB1
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cacnb1):
CACNB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CACNB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DREAM Repression and Dynorphin Expression | | | 2 | PKC-Theta Pathway | | | 3 | Sweet Taste Signaling | | | 4 | Activation of cAMP-Dependent PKA | | | 5 | NFAT and Cardiac Hypertrophy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CACNB1
5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNB1 (see all 38)
1  GeneGo (Thomson Reuters) Pathway for CACNB1
2  BioSystems Pathways for CACNB1
5/7 
Reactome Pathways for CACNB1 (see all 7)
1  PharmGKB Pathway for CACNB1
5 
Kegg Pathways (Kegg details for CACNB1):
CACNB1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/53 Interacting proteins for CACNB1 (Q026412, 3 ENSP000003778404) via UniProtKB, MINT, STRING, and/or I2D (see all 53)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CACNB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CACNB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CACNB1
2 HMDB Compounds for CACNB1 About this table
1 DrugBank Compound for CACNB1 About this table
Search CenterWatch for drugs/clinical trials and news about CACNB1 / CACB1
|
Transcripts
for CACNB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CACNB1 gene (3 alternative transcripts): NM_000723.4 NM_199247.2 NM_199248.2 Unigene Cluster for CACNB1: Calcium channel, voltage-dependent, beta 1 subunit Hs.635 [show with all ESTs]Unigene Representative Sequence: NM_00072311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394303(uc002hrm.2) ENST00000539338(uc002hrl.1 uc010web.1)
ENST00000394310(uc002hrn.3) ENST00000344140(uc002hro.3 uc002hrp.2)
ENST00000582544 ENST00000577582 ENST00000536613 ENST00000492737 ENST00000582877
ENST00000582414 ENST00000577926
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CACNB1 (NM_199248) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB1 |
Additional cDNA sequence: AB054985.1 AK289729.1 AK297643.1 AK300666.1 AK312385.1 AY393857.1 BC037311.1 L06111.1 L06112.1 M76560.1 M92301.1 M92302.1 M92303.1 9 DOTS entries: DT.87046948 DT.100752349 DT.100752352 DT.100019937 DT.120923246 DT.100752351 DT.120923258 DT.40105918 DT.100639288 24/88 AceView cDNA sequences (see all 88): BU733043 BQ722156 BP348268 T28094 BI255280 BM672216 CA975944 AK127283 NM_199247 BU159164 BQ884141 AY393857 AA580171 BI259000 BM805656 NM_199248 NM_000723 BQ927442 L06111 W72250 BI553643 AI762726 AI131419 BV202766
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CACNB1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | - | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for CACNB1
|
Expression
for CACNB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CACNB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGAGGAAG
About this image
See CACNB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNB1
SOURCE GeneReport for Unigene cluster: Hs.635
UniProtKB/Swiss-Prot: CACB1_HUMAN, Q02641Tissue specificity: Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system andneuroblastoma cells. Isoform 2 is expressed in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including CACNB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB1 |
Orthologs
for CACNB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CACNB1 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CACNB16 |
-- |
67(a) |
1 ↔ 1 |
6(67325753-67352048) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX719985.12 |
-- |
78.49(n) |
|
BX719985.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cacnb11 |
calcium channel, voltage-dependent, beta 1 subunit |
76.41(n)
85.06(a) |
|
436925 NM_001002652.1 NP_001002652.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ca-&bgr;3 |
calcium ion transport voltage-gated calcium
channel |
62(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ccb-11 , 3 |
calcium channel subunit3
Protein CCB-11 |
60(a)3
57.14(n)1
57.14(a)1 |
|
I(3641606-3646883)3
1719331 NM_058792.31 NP_491193.21 |
ENSEMBL Gene Tree for CACNB1 (if available)
TreeFam Gene Tree for CACNB1 (if available) |
Paralogs
for CACNB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CACNB1 gene
- CACNB42 CACNB32 CACNB22
4 SIMAP similar genes for CACNB1 using alignment to 2 protein entries: CACB1_HUMAN (see all proteins):CACNB4 CACNB2 CACNB3 CAVB2F
CACNB1 for paralogs About GeneDecksing
|
Genomic Variants
for CACNB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CACNB1 (37329709 - 37353956 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CACNB1
2 CNVs: 49852 5006 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNB1 |
|
Disorders
/ Diseases
for CACNB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CACNB1 for disorders About GeneDecksing
OMIM gene information: 114207
OMIM disorders: --
6  diseases for CACNB1: About MalaCardsmalignant hyperthermia temporal lobe epilepsy malignant hyperthermia susceptibility ataxia
neuroblastoma neuronitis
Export disorders for CACNB1 gene to outside databases
|
Publications
for CACNB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CACNB1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with CACNB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. (PubMed id 8395940)1, 2, 3 Iles D.E.... Wieringa B. (1993)
- Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. (PubMed id 10624822)1, 2 Hogan K.... Powers P.A. (1999)
- Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. (PubMed id 8905728)1, 2 Fukuda K.... Satoh M. (1996)
- Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping. (PubMed id 8381767)1, 3 Gregg R.G....Hogan K. (1993)
- Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. (PubMed id 7916667)1, 2 Collin T.... Schwartz A. (1993)
- Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. (PubMed id 1309651)1, 2 Williams M.E.... Harpold M.M. (1992)
- Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. (PubMed id 1385409)1, 2 Powers P.A.... Gregg R.G. (1992)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- MicroRNA-328 contributes to adverse electrical remode ling in atrial fibrillation. (PubMed id 21098446)1 Lu Y....Yang B. (2010)
|
External Searches for CACNB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CACNB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CACNB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CACNB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CACNB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CACNB1 gene:
Search GeneIP for patents involving CACNB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CACNB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CACNB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNB1 | | | OriGene Protein Over-expression Lysate for CACNB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CACNB1 | | OriGene 3'-UTR Clone for CACNB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CACNB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CACNB1 | | OriGene Custom Protein Services for CACNB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNB1 |
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| | | | Search Tocris compounds for CACNB1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNB1 |
|  |  |  | | | | ThermoFisher Antibodies for CACNB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CACNB1 |
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