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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CACNA2D2 Gene

protein-coding GIFtS: 61
GCID: GC03M050400

calcium channel, voltage-dependent, alpha 2/delta subunit...

Explore 5 diseases affiliated with
CACNA2D2 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 2¹ ²		LUAC11.1²
KIAA0558¹ ³ ⁵		Alpha 2 Delta Calcium Channel Subunit²
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2² ³		Gene 26²
CACNA2D²		Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2²

External Ids:	HGNC: 1400¹	Entrez Gene: 9254²	Ensembl: ENSG00000007402⁷	OMIM: 607082⁵	UniProtKB: Q9NY47³

Export aliases for CACNA2D2 gene to outside databases

Previous GC identifers: GC03P049446 GC03P049615 GC03M050254 GC03M050359 GC03M050375

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CACNA2D2:

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel

complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a

complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these

subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly

similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.

Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CA2D2_HUMAN, Q9NY47

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and

activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel

(CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces

apoptosis

Gene Wiki entry for CACNA2D2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CACNA2D2 gene promoter:
E2F-3a E2F-4 RFX1 USF1 E2F-5 E2F-2 LCR-F1 E2F E2F-1 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CACNA2D2 promoter sequence

Search SABiosciences Chromatin IP Primers for CACNA2D2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNA2D2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

CACNA2D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNA2D2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050400: view genomic region (about GC identifiers)

Start:	50,400,230 bp from pter	End:	50,541,675 bp from pter
Size:	141,446 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA2D2_HUMAN, Q9NY47 (See protein sequence)

Recommended Name: Voltage-dependent calcium channel subunit alpha-2/delta-2 precursor

Size: 1150 amino acids; 129817 Da

Subunit: Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are

multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits

in a 1:1:1:1 ratio (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes with CACNA1A in lipid

raft fractions (By similarity)

Miscellaneous: Binds gabapentin, an antiepileptic drug

Secondary accessions: A7MD15 Q9NY48 Q9UEW0 Q9Y268

Alternative splicing: 5 isoforms: Q9NY47-1 Q9NY47-2 Q9NY47-3 Q9NY47-4 Q9NY47-5

Explore the universe of human proteins at neXtProt for CACNA2D2: NX_Q9NY47

Post-translational modifications:

May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear

whether such cleavage really takes place in vivo and has a functional role (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NY47

CACNA2D2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001005505.1 NP_001167522.1 NP_006021.2

ENSEMBL proteins:

ENSP00000407393 ENSP00000404631 ENSP00000266039 ENSP00000354228 ENSP00000390329

ENSP00000418081 ENSP00000390526 ENSP00000378519

Reactome Protein details: Q9NY47
Human Recombinant Protein Products:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005891	voltage-gated calcium channel complex	IEA	--

CACNA2D2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CACNA2D2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013680 VDCC_a2/dsu

IPR004010 Cache_domain

IPR013608 VWA_N

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry Q9NY47

ProtoNet protein and cluster: Q9NY47

4 Blocks protein families:

IPB002035 Von Willebrand factor type A domain signature

IPB004010 Cache domain

IPB013608 VWA N-terminal

IPB013680 Voltage-dependent calcium channel

UniProtKB/Swiss-Prot: CA2D2_HUMAN, Q9NY47

Domain: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of

the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)

Similarity: Belongs to the calcium channel subunit alpha-2/delta family

Similarity: Contains 1 cache domain

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CA2D2_HUMAN, Q9NY47

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and

activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel

(CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces

apoptosis

Genatlas biochemistry entry for CACNA2D2:

voltage-dependent calcium channel (VDCC),alpha 2-delta regulatory subunit,expressed in brain,localized in a critical

region for lung cancer

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA2D2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005245	voltage-gated calcium channel activity	IEA	--
GO:0005515	protein binding	--	--
GO:0046872	metal ion binding	IEA	--

CACNA2D2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CACNA2D2:

Synthetic lethal with Ras

Synthetic lethal with imatinib

Animal Models:
Mouse knock-out Cacna2d2^tm1Svi for CACNA2D2
13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cacna2d2):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	mortality/aging	muscle	nervous system
reproductive system	respiratory system	skeleton

CACNA2D2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

DREAM Repression and Dynorphin Expression

DREAM Repression and Dynorphin Expression	1.00	Caspase Cascade	0.24
BMP Pathway	0.44	Calpain Protease Regulates Cellular Mechanics	0.22
nNOS Signaling in Skeletal Muscle	0.37

PKC-Theta Pathway

PKC-Theta Pathway	1.00	Fc-EpsilonRI Pathway	0.42
TCR Signaling	0.68	PDGF Pathway	0.35
ITK and TCR Signaling	0.54

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

NFAT and Cardiac Hypertrophy

	NFAT and Cardiac Hypertrophy	1.00			IGF1R Signaling	0.37
	Signaling Involved in Cardiac Hypertrophy	0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CACNA2D2

Transcription CREB pathway

5/37 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNA2D2 (see all 37)

	Caspase Cascade
	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	PDGF Pathway
	BMP Pathway

1 GeneGo (Thomson Reuters) Pathway for CACNA2D2

Transcription CREB pathway

1 BioSystems Pathway for CACNA2D2

Arrhythmogenic right ventricular cardiomyopathy

5/8 Reactome Pathways for CACNA2D2 (see all 8)

	Transmission across Chemical Synapses
	Closing (Inhibition) of L-type Calcium Channels in Pancreatic Beta Cells
	Metabolism
	Regulation of Insulin Secretion
	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline

1 PharmGKB Pathway for CACNA2D2

Celecoxib Pathway, Pharmacodynamics

5 Kegg Pathways (Kegg details for CACNA2D2):

	MAPK signaling pathway
	Cardiac muscle contraction
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathy

CACNA2D2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CACNA2D2

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/15 Interacting proteins for CACNA2D2 (Q9NY47³ ENSP00000390329⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGHA1	P01876³, ENSP00000374989⁴	I2D: score=1 STRING: ENSP00000374989
CACNA1C	Q13936³	I2D: score=1
THBS4	P35443³	I2D: score=1
YWHAB	P31946³	I2D: score=1
PRKACA	ENSP00000309591⁴	STRING: ENSP00000309591

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006816	calcium ion transport	--	--
GO:0007528	neuromuscular junction development	IEA	--
GO:0040014	regulation of multicellular organism growth	IEA	--
GO:0044281	small molecule metabolic process	TAS	--

CACNA2D2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CACNA2D2

2 HMDB Compounds for CACNA2D2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Gabapentin	1-(Aminomethyl)cyclohexaneacetic acid (see all 9)	60142-96-3	--

6 DrugBank Compounds for CACNA2D2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Gabapentin	Gabapentin GR (see all 6)	60142-96-3	target	inhibitor	18299583 16899342 17982508 20588320
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	target	inhibitor	20221978 1281221
Bepridil	--	64706-54-3	target	inhibitor	1281221 7565636
Felodipine	Dl-Felodipine (see all 4)	72509-76-3	target	inhibitor	18974361 1281221
Isradipine	(+/-)-Isradipine (see all 5)	75695-93-1	target	inhibitor	18974361 1281221
Nitrendipine	Nitrendipin (see all 3)	39562-70-4	target	inhibitor	18974361

Search CenterWatch for drugs/clinical trials and news about CACNA2D2 / CA2D2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for CACNA2D2 gene (3 alternative transcripts):

NM_001005505.1 NM_001174051.1 NM_006030.2

Unigene Cluster for CACNA2D2:

Calcium channel, voltage-dependent, alpha 2/delta subunit 2

Hs.476273 [show with all ESTs]

Unigene Representative Sequence: AF040709

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423994 ENST00000429770 ENST00000266039(uc003dap.3) ENST00000360963

ENST00000483620 ENST00000424201 ENST00000479441 ENST00000487413 ENST00000435965(uc003daq.3)

ENST00000395083

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Additional cDNA sequence:

AB011130.1 AF040709.1 AF042792.1 AF042793.1 AJ251367.1 AJ251368.1 AK074820.1 AK310138.1

BC152438.1

10 DOTS entries:

DT.91676580 DT.443954 DT.97804445 DT.100748944 DT.102834667 DT.91676589 DT.100733553 DT.120873146

DT.308038 DT.95078373

24/70 AceView cDNA sequences (see all 70):

AI027237 CR615217 AF042792 BX280981 AA906993 AJ251367 AI191453 AA994701

AI884536 CD621653 BM990784 AI586961 CB240597 AA916808 NM_006030 AK074820

AA534927 AB011130 AJ251368 BM701762 AF040709 AI026646 BE794711 AW302487

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CACNA2D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACCCGGC

About this image

CACNA2D2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Neural Tube

Spinal Dorsal Columns

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CACNA2D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CACNA2D2

SOURCE GeneReport for Unigene cluster: Hs.476273

UniProtKB/Swiss-Prot: CA2D2_HUMAN, Q9NY47

Tissue specificity: Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is

absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also

expressed in kidney, liver, placenta and brain

SABiosciences Custom PCR Arrays for CACNA2D2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CACNA2D2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CACNA2D2¹	calcium channel, voltage-dependent, alpha 2/delta subunit more	80.74(n) 83.33(a)		430150 XM_427707.3 XP_427707.3
lizard (Anolis carolinensis)	Reptilia	CACNA2D2⁶	--	77(a)	1 ↔ 1	2(150148204-150209977)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12126²	Transcribed sequence with moderate similarity to protein more	78.51(n)		BX704606.1
zebrafish (Danio rerio)	Actinopterygii	LOC568759¹	novel protein similar to vertebrate calcium channel more	67.41(n) 66.02(a)		568759 NM_001089420.1 NP_001082889.1
worm (Caenorhabditis elegans)	Secernentea	tag-180⁶	Temporarily Assigned Gene name family member (tag-...	16(a)	possible ortholog	II(11322985-11329365)

ENSEMBL Gene Tree for CACNA2D2 (if available)
TreeFam Gene Tree for CACNA2D2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CACNA2D2 gene

CACNA2D4² CACNA2D1² CACNA2D3² CACHD1²

4 SIMAP similar genes for CACNA2D2 using alignment to 6 protein entries: CA2D2_HUMAN (see all proteins):

CACNA2D1 CACNA2D3 CACNA2D4 WUGSC

CACNA2D2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192987706^1,2		--	50400006(+)	`CTTGTC/TTTTAA`	3	--	ds500¹		0	--	--	--	--
rs59336240^1,2	C	--	50400067(+)	`TATTA-/TAACTGG`	3	--	ds500¹		0	--	--	--	--
rs112636634^1,2	C,	--	50400067(+)	`CCTATTA/-TAACT`	3	--	ds500¹		1		CSA	2
rs45536634^1,2	F,	--	50400081(+)	`TGGAAG/ACAAGT`	3	--	ds500¹		2		NA EA	240
rs142744837^1,2		--	50400132(+)	`CTTCAC/TCCCCT`	3	--	ds500¹		0	--	--	--	--
rs184794942^1,2		--	50400135(+)	`CACCCC/GCTGCA`	3	--	ds500¹		0	--	--	--	--
rs189665431^1,2		--	50400143(+)	`GCAGAC/GCACTA`	3	--	ds500¹		0	--	--	--	--
rs144511449^1,2		--	50400343(+)	`TTTTTC/TGTCGC`	3	--	ut3¹		0	--	--	--	--
rs11539636^1,2	C	--	50400394(+)	`AAAAAG/AGGCAG`	3	--	ut3¹ trp³		1		NA	2
rs148344318^1,2		--	50400508(+)	`TGATGA/GGGATT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CACNA2D2 (50400230 - 50541675 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CACNA2D2
3 CNVs: 68373 30176 4336

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CACNA2D2 for disorders           About GeneDecksing

OMIM gene information: 607082    OMIM disorders: --

5 diseases for CACNA2D2:    About MalaCards

cerebellar ataxia ataxia seizures lung cancer

neuronitis

Export disorders for CACNA2D2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CACNA2D2 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with CACNA2D2)

Utopia: connect your pdf to the dynamic
world of online information

CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. (PubMed id 12555074)^{1, 2} Carboni G.L....Ji L. (2003)
Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit. (PubMed id 10762351)^{1, 2} Hobom M.... Klugbauer N. (2000)
Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). (PubMed id 10766861)^{1, 2} Gao B....Minna J.D. (2000)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (1998)
Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene. (PubMed id 11851383)^{1, 9} Honorio S....Latif F. (2001)
Alterations of RASSF1A in premalignant cervical lesion s: clinical and prognostic significance. (PubMed id 21809394)¹ Mitra S....Panda C.K. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
[Clinical pharmacology and electrophysiological prope rties of dronedarone]. (PubMed id 20221978)⁷ Lewalter T....Hohnloser S. (2010)
Gabapentin suppresses cortical spreading depression s usceptibility. (PubMed id 20588320)⁷ Hoffmann U....Ayata C. (2010)
Molecular pharmacology of human Cav3.2 T-type Ca2+ ch annels: block by antihypertensives, antiarrhythmics, and their analogs. (PubMed id 18974361)⁷ Perez-Reyes E....Vitko I. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9254	HGNC: 1400	AceView: CACNA2D2	Ensembl:ENSG00000007402	euGenes: HUgn9254
ECgene: CACNA2D2	Kegg: 9254	H-InvDB: CACNA2D2

(According to HUGE)
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HUGE: KIAA0558

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CACNA2D2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CACNA2D2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CACNA2D2 gene:
Search GeneIP for patents involving CACNA2D2

GeneCards and IP:
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