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CACNA2D1 Gene

protein-coding GIFtS: 60

GC07M081417

calcium channel, voltage-dependent, alpha 2/delta subunit 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CACNL2A, CACNA2, MHS3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CACNA2 ^²
CACNL2A ^², ³
CCHL2A ^², ³
MHS3 ^³

Descriptions
Voltage-gated calcium channel subunit alpha-2/delta-1 ^³
calcium channel, L type, alpha 2 polypeptide ^²
calcium channel, voltage-dependent, alpha 2/delta subunit 1 ^²
dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit ^²

External Ids
HGNC: 1399¹
Entrez Gene: 781²
UniProtKB: P54289³
Ensembl: ENSG00000153956⁷

Search outside databases for aliases for CACNA2D1 gene

Previous GC identifers: GC07M080114 GC07M081177 GC07M081191 GC07M081224

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CACNA2D1:

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent

calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon

membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits

in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described

in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice

variants of this gene have been observed but have not been thoroughly characterized. [provided by

RefSeq]

UniProtKB/Swiss-Prot: CA2D1_HUMAN, P54289

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current

density and activation/inactivation kinetics of the calcium channel. Plays an important role in

excitation-contraction coupling (By similarity)

Gene Wiki entry for CACNA2D1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CACNA2D1 gene

Entrez Gene cytogenetic band: 7q21-q22 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21-q22

CACNA2D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M081417: (about GC identifiers)

Start:	81,417,354 bp from pter
End:	81,910,967 bp from pter
Size:	493,614 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 80,910,288-81,405,123

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CA2D1_HUMAN, P54289 (See protein sequence)

Recommended Name: Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor

Size: 1091 amino acids; 123183 Da

Subunit: Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium

channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta

(CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Miscellaneous: Binds gabapentin, an antiepileptic drug

Secondary accessions: Q17R45

Post-translational modifications:

Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By

similarity)¹

REFSEQ proteins: NP_000713.2

ENSEMBL proteins:

ENSP00000284088 ENSP00000349320 ENSP00000348589

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calcium channel L type DHPR alpha 2 subunit)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005891	voltage-gated calcium channel complex	IDA	11160515
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for CACNA2D1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CACNA2D1
	Sigma-Aldrich Antibodies for CACNA2D1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Calcium channel L type DHPR alpha 2 subunit), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CACNA2D1)
	Novus Biologicals Antibody for CACNA2D1

Assays for CACNA2D1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P54289

ProtoNet protein and cluster: P54289

4 Blocks protein families:

IPB002035 Von Willebrand factor type A domain signature

IPB004010 Cache domain

IPB013608 VWA N-terminal

IPB013680 Voltage-dependent calcium channel

UniProtKB/Swiss-Prot: CA2D1_HUMAN, P54289

Domain: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to

promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like

switch (By similarity)

Similarity: Belongs to the calcium channel subunit alpha-2/delta family

Similarity: Contains 1 cache domain

Similarity: Contains 1 VWFA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CACNA2D1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CACNA2D1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000722

Applied Biosystems Silencer® siRNAs for CACNA2D1

Sigma-Aldrich siRNA and siRNA Panels for CACNA2D1

Sigma-Aldrich shRNA Panels and shRNA for CACNA2D1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000722
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000722
untagged cDNA clone in CMV expression vector: NM_000722

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000722

UniProtKB/Swiss-Prot: CA2D1_HUMAN, P54289

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current

density and activation/inactivation kinetics of the calcium channel. Plays an important role in

excitation-contraction coupling (By similarity)

Genatlas biochemistry entry for CACNA2D1:

transverse tubule (TT) calcium voltage-gated channel (VDCC),L (long lasting) type,dihydropyridine

(DHP) sensitive,alpha 2-delta regulatory subunit,(140+25kDa),skeletal muscle

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cacna2d1):

homeostasis/metabolism

nervous system

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0015270	contributes to dihydropyridine-sensitive calcium channel activity	IDA	11160515

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/94 Interacting proteins for CACNA2D1 (ENSP00000349320³) via UniProtKB, MINT, and/or STRING (see all 94 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNA1D	ENSP00000288139³	STRING (score=.996)
CACNA1E	ENSP00000356545³	STRING (score=.994)
CACNA1G	ENSP00000352011³	STRING (score=.994)
CACNA1A	ENSP00000353362³	STRING (score=.993)
CACNA1B	ENSP00000277549³	STRING (score=.992)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006816	calcium ion transport	IDA	11160515

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CACNA2D1

Sigma-Aldrich Small Molecules for CACNA2D1:

Antagonist Blocker

Browse Tocris compounds for CACNA2D1
1 Novoseek chemical compound relationship for CACNA2D1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	34.50	5	10534405 (2), 15526345 (1), 15467389 (1), 17084535 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CACNA2D1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CACNA2D1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000722

Sigma-Aldrich siRNA and siRNA Panels for CACNA2D1

Sigma-Aldrich shRNA Panels and shRNA for CACNA2D1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000722

REFSEQ mRNAs for CACNA2D1 gene:

NM_000722.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000722

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000722
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000722
                                 untagged cDNA clone in CMV expression vector: NM_000722

Additional cDNA sequence:

AK299838.1 BC051339.1 BC117468.1 BC117470.1 M76559.1

9 DOTS entries:

DT.311566 DT.100746795 DT.95154989 DT.92421642 DT.70105027 DT.92421641 DT.102832210 DT.75167061

DT.95154990

16 AceView cDNA sequences:

BX105436 AI223011 AW051755 N85205 AL134437 BI545104 BC051339 AL707206

BU501177 NM_000722 M76559 BG201986 AL596587 BF971434 AI434840 AA969854

highest scoring ESTs for CACNA2D1:

M76559 AI360484 AI797108 AL707206 AW051755 AW137807 BC051339 BE550252 BE670688 BG055272

Unigene Cluster for CACNA2D1:

Calcium channel, voltage-dependent, alpha 2/delta subunit 1

Hs.282151 [show with all ESTs]

Unigene Representative Sequence: NM_000722

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000284088 ENST00000356860 ENST00000356253

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CACNA2D1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CACNA2D1

¹ / ² / ³

3 probe-sets matching CACNA2D1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35527_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M76559	1.00	1.00	1.00	1
207050_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000722	0.60	1.00	0.82	1
207050_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CACNA2D1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTATTCTGG

SOURCE GeneReport for Unigene cluster: Hs.282151
Expression variation in blood from EXPOLDB for CACNA2D1
UniProtKB/Swiss-Prot: CA2D1_HUMAN, P54289
Tissue specificity: Central nervous system, skeletal muscle and aorta tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CACNA2D1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CACNA2D1¹	--	calcium channel, voltage-dependent, alpha 2/delta subunit more	91.9(n) 97.07(a)	610342 XM_847825.1 XP_852918.1
chimpanzee (Pan troglodytes)	CACNA2D1¹	--	calcium channel, voltage-dependent, alpha 2/delta subunit more	99.76(n) 99.82(a)	463504 XM_001160235.1 XP_001160235.1
cow (Bos taurus)	CACNA2D1¹	--	calcium channel, voltage-dependent, alpha 2/delta subunit more	93.74(n) 98.08(a)	282608 XM_609993.3 XP_609993.3
rat (Rattus norvegicus)	Cacna2d1¹	--	calcium channel, voltage-dependent, alpha2/delta subunit more	89.6(n) 96.33(a)	25399 NM_012919.2 NP_037051.2
mouse (Mus musculus)	Cacna2d1^{1, 5}	5 (4.00 cM)⁵	calcium channel, voltage-dependent, alpha2/delta subunit more^{1, 5}	89.94(n)¹ 96.4(a)¹	12293¹ NM_009784.1¹ NP_033914.1¹ AA217038⁵ AI465482⁵ (see all 18)

About this table Species with no ortholog for CACNA2D1

ENSEMBL Gene Tree for CACNA2D1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CACNA2D1 gene

CACNA2D4² CACNA2D2² CACNA2D3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2911 NCBI SNPs in CACNA2D1 are shown (see all 2911 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1139)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs35131433^1,2	C,F	81426552(-)	`GCCTGA/CTGTCT`	1	D/A	mis¹		5		NA EU EA WA	490
	rs9886043^1,2	F,H	81427027(+)	`TTGCTC/GTCAAC`	1	E/D	mis¹ ese³		4		EU EA WA	388
--	rs6954596^1,2	A,C	81910894(+)	`CGCCGA/GGGAAG`	1	--	ut5¹ ese³ trp³		0	--	--	--	--
	rs10240864^1,2	H	81533716(+)	`GTCTTC/TTGCGT`	1	R/K	mis¹ ese³		4		EU EA WA	420
--	rs17156339^1,2	F	81911952(-)	`GTGAGC/TTCACC`	1	--	ng3¹		2		MN EA	356
	rs10240863^1,2	H	81533713(+)	`ATGGTC/TTTCTG`	1	R/K	mis¹ ese³		4		EU EA WA	418
	rs10253847^1,2	H	81816841(+)	`ACTCCA/CCTTGC`	1	S/R	mis¹		4		EU EA WA	420
	rs10240876^1,2	H	81533752(+)	`GAGTTC/TTACTA`	1	R/K	mis¹ ese³		4		EU EA WA	420
	rs1229502^1,2	A,C,F,H,O	81426572(+)	`TATCTG/AGGTTG`	1	P/P	syn¹		9		MN NA EU EA WA	642
	rs37133^1,2	F,H	81479489(+)	`ATCCAA/GATATT`	1	L/L	syn¹		4		EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for CACNA2D1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114204

Human Genome Epidemiology Navigator: CACNA2D1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/21 PubMed articles for CACNA2D1 gene (see all 21 ):

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis. (PubMed id 8188232)^{2, 3} Powers P.A....Hogan K. (1994)
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. (PubMed id 1309651)^{3, 4} Williams M.E.... Harpold M.M. (1992)
Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). (PubMed id 10534405)^{1, 3} Schleithoff L.... Lehmann-Horn F. (1999)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. (PubMed id 19001023)³ Thiel W.H....Anderson M.E. (2008)
Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. (PubMed id 17438119)³ Chaudhuri D....Yue D.T. (2007)
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. (PubMed id 17224476)³ Antzelevitch C.... Wolpert C. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 781	HGNC: 1399	AceView: CACNA2D1	Ensembl:ENSG00000153956	euGenes: HUgn781
ECgene: CACNA2D1	H-InvDB: CACNA2D1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CACNA2D1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CACNA2D1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CACNA2D1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CACNA2D1		Antibodies for CACNA2D1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CACNA2D1		Small molecules for CACNA2D1
	"Your Favorite Gene" Pathways		feedback

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	Drugs for CACNA2D1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CACNA2D1

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CACNA2D1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CACNA2D1

Summaries
for CACNA2D1

Genomic Location
for CACNA2D1

Proteins
for CACNA2D1

Protein Domains/
Families
for CACNA2D1

Gene Function
for CACNA2D1

Pathways & Interactions
for CACNA2D1

Drugs & Compounds
for CACNA2D1

Transcripts
for CACNA2D1

Expression
for CACNA2D1

Orthologs
for CACNA2D1

Paralogs
for CACNA2D1

SNPs/Variants
for CACNA2D1

Disorders & Mutations
for CACNA2D1

Medical News
for CACNA2D1

Publications
for CACNA2D1

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Genome Databases showing CACNA2D1

Other Databases showing CACNA2D1

Specialized Databases showing CACNA2D1

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CACNA2D1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CACNA2D1

Summariesfor CACNA2D1

Genomic Locationfor CACNA2D1

Proteinsfor CACNA2D1

Protein Domains/Familiesfor CACNA2D1

Gene Functionfor CACNA2D1

Pathways & Interactionsfor CACNA2D1

Drugs & Compoundsfor CACNA2D1

Transcriptsfor CACNA2D1

Expression for CACNA2D1

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Paralogsfor CACNA2D1

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Disorders & Mutationsfor CACNA2D1

Medical Newsfor CACNA2D1

Publicationsfor CACNA2D1

Search for CACNA2D1

Genome Databases showing CACNA2D1

Other Databases showing CACNA2D1

Specialized Databases showing CACNA2D1

Licensable Technologiesfor CACNA2D1

Servicesfor CACNA2D1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CACNA2D1

Summaries
for CACNA2D1

Genomic Location
for CACNA2D1

Proteins
for CACNA2D1

Protein Domains/
Families
for CACNA2D1

Gene Function
for CACNA2D1

Pathways & Interactions
for CACNA2D1

Drugs & Compounds
for CACNA2D1

Transcripts
for CACNA2D1

Expression
for CACNA2D1

Orthologs
for CACNA2D1

Paralogs
for CACNA2D1

SNPs/Variants
for CACNA2D1

Disorders & Mutations
for CACNA2D1

Medical News
for CACNA2D1

Publications
for CACNA2D1

Licensable Technologies
for CACNA2D1

Services
for CACNA2D1