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Aliases for CACNA1I Gene

Aliases for CACNA1I Gene

  • Calcium Channel, Voltage-Dependent, T Type, Alpha 1I Subunit 2 3
  • Voltage-Gated Calcium Channel Subunit Alpha Cav3.3 3 4
  • Ca(V)3.3 3 4
  • KIAA1120 4 6
  • Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I 3
  • Calcium Channel, Voltage-Dependent, Alpha 1I Subunit 3
  • Cav3.3 3

External Ids for CACNA1I Gene

Previous GeneCards Identifiers for CACNA1I Gene

  • GC22P036581
  • GC22P038209
  • GC22P038291
  • GC22P039966
  • GC22P022931

Summaries for CACNA1I Gene

Entrez Gene Summary for CACNA1I Gene

  • This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for CACNA1I Gene

CACNA1I (Calcium Channel, Voltage-Dependent, T Type, Alpha 1I Subunit) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include voltage-gated calcium channel activity and low voltage-gated calcium channel activity. An important paralog of this gene is CACNA1D.

UniProtKB/Swiss-Prot for CACNA1I Gene

  • Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).

Tocris Summary for CACNA1I Gene

  • Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Gene Wiki entry for CACNA1I Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA1I Gene

Genomics for CACNA1I Gene

Regulatory Elements for CACNA1I Gene

Genomic Location for CACNA1I Gene

Start:
39,570,753 bp from pter
End:
39,689,738 bp from pter
Size:
118,986 bases
Orientation:
Plus strand

Genomic View for CACNA1I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNA1I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA1I Gene

Proteins for CACNA1I Gene

  • Protein details for CACNA1I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0X4-CAC1I_HUMAN
    Recommended name:
    Voltage-dependent T-type calcium channel subunit alpha-1I
    Protein Accession:
    Q9P0X4
    Secondary Accessions:
    • B0QY12
    • B0QY13
    • B0QY14
    • O95504
    • Q5JZ88
    • Q7Z6S9
    • Q8NFX6
    • Q9NZC8
    • Q9UH15
    • Q9UH30
    • Q9ULU9
    • Q9UNE6

    Protein attributes for CACNA1I Gene

    Size:
    2223 amino acids
    Molecular mass:
    245103 Da
    Quaternary structure:
    • Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.

    Alternative splice isoforms for CACNA1I Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNA1I Gene

Proteomics data for CACNA1I Gene at MOPED

Post-translational modifications for CACNA1I Gene

  • In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
  • Glycosylation at Asn173, Asn244, Asn311, Asn1342, and Asn1345
  • Modification sites at PhosphoSitePlus

Other Protein References for CACNA1I Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNA1I Gene

Domains for CACNA1I Gene

Gene Families for CACNA1I Gene

HGNC:
  • CACN :Calcium channel subunits
  • CACN1 :Voltage-gated ion channels / Calcium channels
IUPHAR :

Suggested Antigen Peptide Sequences for CACNA1I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0X4

UniProtKB/Swiss-Prot:

CAC1I_HUMAN :
  • Q9P0X4
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position
Family:
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily.
genes like me logo Genes that share domains with CACNA1I: view

Function for CACNA1I Gene

Molecular function for CACNA1I Gene

GENATLAS Biochemistry: calcium low activated (LVA) voltage-gated channel,T type alpha 1I subunit,predominantly expressed in brain,involved in pacing neuronal firing and producing network oscillations such as those that occurs during sleeep and epilepsy (potential drug target),existing as two alternatively spliced forms
UniProtKB/Swiss-Prot Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).

Gene Ontology (GO) - Molecular Function for CACNA1I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005245 voltage-gated calcium channel activity IBA --
GO:0005515 protein binding IPI 16740636
GO:0008332 low voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with CACNA1I: view

Animal Model Products

miRNA for CACNA1I Gene

miRTarBase miRNAs that target CACNA1I

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CACNA1I Gene

Localization for CACNA1I Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA1I Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNA1I Gene COMPARTMENTS Subcellular localization image for CACNA1I gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CACNA1I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CACNA1I: view

Pathways for CACNA1I Gene

genes like me logo Genes that share pathways with CACNA1I: view

Pathways by source for CACNA1I Gene

1 GeneGo (Thomson Reuters) pathway for CACNA1I Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CACNA1I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10454147
GO:0006811 ion transport --
GO:0007165 signal transduction TAS 10454147
GO:0007411 axon guidance TAS --
GO:0019228 neuronal action potential IEA --
genes like me logo Genes that share ontologies with CACNA1I: view

Compounds for CACNA1I Gene

(5) Tocris Compounds for CACNA1I Gene

Compound Action Cas Number
Isradipine Ca2+ channel blocker (L-type) [75695-93-1]
Mibefradil dihydrochloride Ca2+ channel blocker (T-type) [116666-63-8]
omega-Conotoxin GVIA Ca2+ channel blocker (N-type) [106375-28-4]
Pregabalin Anticonvulsant; selectively binds the alpha2delta subunit of voltage-sensitive calcium channels [148553-50-8]
SNX 482 Potent and selective CaV2.3 blocker (R-type) [203460-30-4]

(2) HMDB Compounds for CACNA1I Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Verapamil
  • Akilen
52-53-9

(6) Drugbank Compounds for CACNA1I Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cinnarizine
298-57-7 target inhibitor
Flunarizine
  • (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine
52468-60-7 target inhibitor
Mibefradil
116644-53-2 target inhibitor
Paramethadione
115-67-3 target suppressor
Verapamil
  • Verapamil [Usan:Ban:Inn]
52-53-9 target inhibitor

(6) IUPHAR Ligand for CACNA1I Gene

Ligand Type Action Affinity Pubmed IDs
mibefradil Pore Blocker Antagonist 6.8
pimozide Antagonist Antagonist 6.2
anandamide Channel blocker None
SB209712 Channel blocker None
kurtoxin Channel blocker None
Ni2+ Channel blocker None

(1) Novoseek inferred chemical compound relationships for CACNA1I Gene

Compound -log(P) Hits PubMed IDs
calcium 56.5 9
genes like me logo Genes that share compounds with CACNA1I: view

Transcripts for CACNA1I Gene

Unigene Clusters for CACNA1I Gene

Calcium channel, voltage-dependent, T type, alpha 1I subunit:
Representative Sequences:

miRNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CACNA1I

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1I Gene

No ASD Table

Relevant External Links for CACNA1I Gene

GeneLoc Exon Structure for
CACNA1I
ECgene alternative splicing isoforms for
CACNA1I

Expression for CACNA1I Gene

mRNA expression in normal human tissues for CACNA1I Gene

mRNA differential expression in normal tissues according to GTEx for CACNA1I Gene

This gene is overexpressed in Brain - Cortex (5.9), Brain - Cerebellum (4.7), and Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNA1I Gene

SOURCE GeneReport for Unigene cluster for CACNA1I Gene Hs.125116

mRNA Expression by UniProt/SwissProt for CACNA1I Gene

Q9P0X4-CAC1I_HUMAN
Tissue specificity: Brain specific
genes like me logo Genes that share expressions with CACNA1I: view

In Situ Assay Products

Orthologs for CACNA1I Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA1I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACNA1I 35
  • 98.72 (n)
  • 98.76 (a)
CACNA1I 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACNA1I 35
  • 90.61 (n)
  • 93.65 (a)
CACNA1I 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNA1I 35
  • 91.08 (n)
  • 93.98 (a)
CACNA1I 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacna1i 35
  • 87.97 (n)
  • 93.7 (a)
Cacna1i 16
Cacna1i 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACNA1I 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNA1I 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacna1i 35
  • 87.56 (n)
  • 93.56 (a)
chicken
(Gallus gallus)
Aves CACNA1I 35
  • 76.82 (n)
  • 82.08 (a)
CACNA1I 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNA1I 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacna1i 35
  • 70.63 (n)
  • 77.94 (a)
zebrafish
(Danio rerio)
Actinopterygii cacna1i 35
  • 67.93 (n)
  • 70.47 (a)
cacna1i 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cac 36
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cca-1 36
  • 44 (a)
OneToMany
cca-1 37
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
Species with no ortholog for CACNA1I:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACNA1I Gene

ENSEMBL:
Gene Tree for CACNA1I (if available)
TreeFam:
Gene Tree for CACNA1I (if available)

Paralogs for CACNA1I Gene

Selected SIMAP similar genes for CACNA1I Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CACNA1I: view

Variants for CACNA1I Gene

Sequence variations from dbSNP and Humsavar for CACNA1I Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4374 -- 39,589,585(+) CTTCC(A/G)GGAAG intron-variant
rs132567 -- 39,577,521(+) GAGGG(A/G)ATGGC intron-variant
rs132569 -- 39,579,663(+) AGCTC(-/T)TTTTT intron-variant
rs132570 -- 39,580,123(+) ggaga(A/C)acaca intron-variant
rs132571 -- 39,580,128(+) cacac(A/C)tcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNA1I Gene

Variant ID Type Subtype PubMed ID
nsv915099 CNV Loss 21882294
nsv834200 CNV Loss 17160897
esv2724256 CNV Deletion 23290073
esv2724257 CNV Deletion 23290073
esv1010347 CNV Deletion 20482838
dgv4975n71 CNV Loss 21882294
dgv4976n71 CNV Loss 21882294
nsv915106 CNV Loss 21882294
esv2086990 CNV Deletion 18987734
esv2724258 CNV Deletion 23290073

Relevant External Links for CACNA1I Gene

HapMap Linkage Disequilibrium report
CACNA1I
Human Gene Mutation Database (HGMD)
CACNA1I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA1I Gene

Disorders for CACNA1I Gene

Relevant External Links for CACNA1I

Genetic Association Database (GAD)
CACNA1I
Human Genome Epidemiology (HuGE) Navigator
CACNA1I
genes like me logo Genes that share disorders with CACNA1I: view

No data available for UniProtKB/Swiss-Prot for CACNA1I Gene

Publications for CACNA1I Gene

  1. Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. (PMID: 16740636) Zhang D. … Gopalakrishnan M. (J. Biol. Chem. 2006) 3 4 23
  2. Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit. (PMID: 10454147) Mittman S. … Agnew W.S. (Neurosci. Lett. 1999) 2 3 4
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Specific properties of T-type calcium channels generated by the human alpha1I subunit. (PMID: 10749850) Monteil A. … Nargeot J. (J. Biol. Chem. 2000) 3 4

Products for CACNA1I Gene

Sources for CACNA1I Gene

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