Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CACNA1I Gene

protein-coding   GIFtS: 65
GCID: GC22P039966

Calcium Channel, Voltage-Dependent, T Type, Alpha 1I Subunit

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Calcium Channel, Voltage-Dependent, T Type, Alpha 1I Subunit1 2     ca(v)3.32
Voltage-Gated Calcium Channel Subunit Alpha Cav3.32 3     Calcium Channel, Voltage-Dependent, Alpha 1I Subunit2
KIAA11203 5     Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I2
Cav3.32     Ca(v)3.33

External Ids:    HGNC: 13961   Entrez Gene: 89112   Ensembl: ENSG000001003467   OMIM: 6082305   UniProtKB: Q9P0X43   

Export aliases for CACNA1I gene to outside databases

Previous GC identifers: GC22P036581 GC22P038209 GC22P038291 GC22P022931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CACNA1I Gene:
This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a
member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The
channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type
calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Oct 2011)

GeneCards Summary for CACNA1I Gene:
CACNA1I (calcium channel, voltage-dependent, T type, alpha 1I subunit) is a protein-coding gene. GO annotations related to this gene include voltage-gated calcium channel activity and low voltage-gated calcium channel activity. An important paralog of this gene is SCN5A.

UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are
also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or
neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives
rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and
are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite
negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both
central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth
muscle. They may also be involved in the modulation of firing patterns of neurons which is important for
information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than
alpha 1G or alpha 1H (By similarity)

summary for CACNA1I Gene:
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium
influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion,
neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct
subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and
gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of
voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families.
Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated
dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Gene Wiki entry for CACNA1I Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CACNA1I gene promoter:
         TBP   AP-1   MyoD   AP-2gamma   Egr-2   POU2F1   POU2F1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCACNA1I promoter sequence
   Search Chromatin IP Primers for CACNA1I

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACNA1I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CACNA1I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNA1I gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039966:  view genomic region     (about GC identifiers)

Start:
39,966,758 bp from pter      End:
40,085,742 bp from pter
Size:
118,985 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4 (See protein sequence)
Recommended Name: Voltage-dependent T-type calcium channel subunit alpha-1I  
Size: 2223 amino acids; 245103 Da
Subunit: Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity
Secondary accessions: B0QY12 B0QY13 B0QY14 O95504 Q5JZ88 Q7Z6S9 Q8NFX6 Q9NZC8 Q9UH15 Q9UH30
Q9ULU9 Q9UNE6
Alternative splicing: 4 isoforms:  Q9P0X4-1   Q9P0X4-2   Q9P0X4-3   Q9P0X4-4   

Explore the universe of human proteins at neXtProt for CACNA1I: NX_Q9P0X4

Explore proteomics data for CACNA1I at MOPED

Post-translational modifications: 

  • In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II (By
    similarity)1
  • Glycosylation2 at Asn173, Asn244, Asn311, Asn1342, Asn1345
  • Modification sites at PhosphoSitePlus

  • See CACNA1I Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003406.1  NP_066919.2  

    ENSEMBL proteins: 
     ENSP00000385680   ENSP00000383887   ENSP00000384093   ENSP00000385019   ENSP00000337829  
     ENSP00000383028  
    Reactome Protein details: Q9P0X4

    CACNA1I Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CACNA1I
    GenScript Custom Purified and Recombinant Proteins Services for CACNA1I
    Novus Biologicals CACNA1I Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CACNA1I 

     
    antibodies-online proteins for CACNA1I (2 products) 

     
    antibodies-online peptides for CACNA1I

    CACNA1I Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CACNA1I
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CACNA1I
    Novus Biologicals CACNA1I Antibodies
    Abcam antibodies for CACNA1I
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CACNA1I
    antibodies-online antibodies for CACNA1I (15 products) 

    CACNA1I Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CACNA1I
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CACNA1I
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CACNA1I 
    antibodies-online kits for CACNA1I (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CACN: Calcium channel subunits
    CACN1: Voltage-gated ion channels / Calcium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cav3.3
    Voltage-gated calcium channels

    4 InterPro protein domains:
     IPR005821 Ion_trans_dom
     IPR005445 VDCC_T_a1su
     IPR027359 Channel_four-helix_dom
     IPR002077 VDCCAlpha1

    Graphical View of Domain Structure for InterPro Entry Q9P0X4

    ProtoNet protein and cluster: Q9P0X4

    1 Blocks protein domain: IPB005445 T-type voltage-dependent calcium channel alpha-1 subunit signature

    UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
    Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6)
    and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are
    characterized by a series of positively charged amino acids at every third position
    Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily


    Find genes that share domains with CACNA1I           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAC1I_HUMAN, Q9P0X4
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are
    also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or
    neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives
    rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and
    are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite
    negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both
    central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth
    muscle. They may also be involved in the modulation of firing patterns of neurons which is important for
    information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than
    alpha 1G or alpha 1H (By similarity)

         Genatlas biochemistry entry for CACNA1I:
    calcium low activated (LVA) voltage-gated channel,T type alpha 1I subunit,predominantly expressed in
    brain,involved in pacing neuronal firing and producing network oscillations such as those that occurs during
    sleeep and epilepsy (potential drug target),existing as two alternatively spliced forms

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005245voltage-gated calcium channel activity IEA--
    GO:0005515protein binding IPI16740636
    GO:0008332low voltage-gated calcium channel activity ----
         
    Find genes that share ontologies with CACNA1I           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cacna1i (no phenotypes)

    Find genes that share phenotypes with CACNA1I           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CACNA1I

    miRNA
    Products:
        
    miRTarBase miRNAs that target CACNA1I:
    hsa-mir-324-3p (MIRT042844)

    Block miRNA regulation of human, mouse, rat CACNA1I using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CACNA1I (see all 61):
    hsa-let-7d hsa-miR-99b* hsa-miR-4272 hsa-miR-765 hsa-miR-200a hsa-miR-25 hsa-miR-938 hsa-miR-503
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CACNA1I
    Predesigned siRNA for gene silencing in human, mouse, rat CACNA1I

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CACNA1I

    Clone
    Products:
         
    OriGene clones in human, mouse for CACNA1I (see all 7)
    OriGene ORF clones in mouse, rat for CACNA1I
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CACNA1I (NM_021096)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNA1I
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1I
    Addgene plasmids for CACNA1I 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CACNA1I
    Browse ESI BIO Cell Lines and PureStem Progenitors for CACNA1I 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1I


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CAC1I_HUMAN, Q9P0X4: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005891voltage-gated calcium channel complex IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with CACNA1I           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CACNA1I About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    Fc-EpsilonRI Pathway0.49
    TCR Signaling0.68
    PDGF Pathway0.39
    ITK and TCR Signaling0.54
    2DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression0.44
    Caspase Cascade0.36
    BMP Pathway0.44
    Calpain Protease Regulates Cellular Mechanics0.31
    nNOS Signaling in Skeletal Muscle0.37
    3Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72
    Sperm Motility0.37
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    5G-Beta Gamma Signaling
    G-Beta Gamma Signaling0.46
    CRHR Pathway0.44
    GHRH Signaling0.46


    Find genes that share SuperPaths with CACNA1I           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CACNA1I (see all 36)
        Caspase Cascade
    Fc-GammaR Pathway
    PDGF Pathway
    BMP Pathway
    ITK and TCR Signaling

    1 GeneGo (Thomson Reuters) Pathway for CACNA1I
        Transcription CREB pathway

    1 Reactome Pathway for CACNA1I
        NCAM1 interactions

    1 PharmGKB Pathway for CACNA1I
        Celecoxib Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CACNA1I):
        MAPK signaling pathway
    Calcium signaling pathway
    Circadian entrainment

        Pathway & Disease-focused RT2 Profiler PCR Array including CACNA1I: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CACNA1I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CACNA1I (Q9P0X41, 3 ENSP000003850194) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CATSPER1Q8NEC51, 3, ENSP000003090524EBI-1220829,EBI-744545 I2D: score=1 STRING: ENSP00000309052
    CATSPER2Q96P561, 3EBI-1220829,EBI-2215024 I2D: score=1 
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    KCND2Q9NZV83I2D: score=1 
    KCNIP3Q9Y2W73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10454147
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0007165signal transduction TAS10454147
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with CACNA1I           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CACNA1I available from Tocris Bioscience    About this table
    CompoundAction CAS #
    omega-Conotoxin GVIACa2+ channel blocker (N-type)[106375-28-4]
    (+-)-Bay K 8644Ca2+-channel activator (L-type)[71145-03-4]
    NNC 55-0396 dihydrochlorideHighly selective Ca2+ channel blocker (T-type)[357400-13-6]
    PregabalinAnticonvulsant. Selectively binds the alpha2delta subunit of voltage-sensitive calcium channels[148553-50-8]
    Mibefradil dihydrochlorideCa2+ channel blocker (T-type)[116644-53-2]

    2 HMDB Compounds for CACNA1I    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    VerapamilAkilen (see all 107)52-53-9--

    6 DrugBank Compounds for CACNA1I    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor20025128 17762320 14704463 19557119 14965331 18433351 20001433 15511691 19948168 20502722
    Flunarizine(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine (see all 6)52468-60-7targetinhibitor19582593 17139284 11784784 17016423
    Mibefradil-- 116644-53-2targetinhibitor9375939 16899990 15562257 9481612
    Cinnarizine-- 298-57-7targetinhibitor3530295 1281221
    Paramethadione-- 115-67-3targetsuppressor17139284 17016423
    VerapamilVerapamil [Usan:Ban:Inn] (see all 4)52-53-9targetinhibitor17139284 17016423

    6 IUPHAR Ligands for CACNA1I (Cav3.3)    About this table
    LigandTypeActionAffinityPubmed IDs
    pimozide
    Pore BlockerAntagonist7.511784784
    anandamide
    Pore BlockerAntagonist611742980
    mibefradil
    Pore BlockerAntagonist5.810991994
    SB209712
    Channel blockerNone5.8--
    kurtoxin
    Channel blockerNone5.8--
    Ni2+
    Channel blockerNone5.8--

    1 Novoseek inferred chemical compound relationship for CACNA1I gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 56.5 10 16740636 (2), 11860462 (1), 17317015 (1), 17082234 (1) (see all 8)



    Find genes that share compounds with CACNA1I           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CACNA1I gene (2 alternative transcripts): 
    NM_001003406.1  NM_021096.3  

    Unigene Cluster for CACNA1I:

    Calcium channel, voltage-dependent, T type, alpha 1I subunit
    Hs.125116  [show with all ESTs]
    Unigene Representative Sequence: NM_021096
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407673 ENST00000401624(uc003aye.3 uc003ayf.3) ENST00000404898
    ENST00000402142(uc003ayc.3 uc003ayd.3) ENST00000471970 ENST00000336649
    ENST00000400164
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CACNA1I using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CACNA1I (see all 61):
    hsa-let-7d hsa-miR-99b* hsa-miR-4272 hsa-miR-765 hsa-miR-200a hsa-miR-25 hsa-miR-938 hsa-miR-503
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CACNA1I
    Predesigned siRNA for gene silencing in human, mouse, rat CACNA1I
    Clone
    Products:
         
    OriGene clones in human, mouse for CACNA1I (see all 7)
    OriGene ORF clones in mouse, rat for CACNA1I
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CACNA1I (NM_021096)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNA1I
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1I
    Addgene plasmids for CACNA1I 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CACNA1I
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CACNA1I
      QuantiTect SYBR Green Assays in human, mouse, rat CACNA1I
      QuantiFast Probe-based Assays in human, mouse, rat CACNA1I

    Additional mRNA sequence: 

    AB032946.1 AF129133.1 AF142567.1 AF211189.1 AF393329.1 BC042972.1 

    3 DOTS entries:

    DT.100743777  DT.40125911  DT.40272792 

    Selected AceView cDNA sequences (see all 32):

    BF879321 H55617 BQ637689 AB032946 BX101763 F13540 AF211189 AF129133 
    BX951618 N57586 BF940871 AJ573520 NM_021096 AF142567 BM695724 BC042972 
    F11119 NM_001003406 N52765 BE164503 BX488084 BI666530 BG707996 AF393329 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CACNA1I expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCAGTCA
    CACNA1I Expression
    About this image


    CACNA1I expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
    CACNA1I Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CACNA1I Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125116

    UniProtKB/Swiss-Prot: CAC1I_HUMAN, Q9P0X4
    Tissue specificity: Brain specific

        Pathway & Disease-focused RT2 Profiler PCR Array including CACNA1I: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CACNA1I
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CACNA1I
    QuantiTect SYBR Green Assays in human, mouse, rat CACNA1I
    QuantiFast Probe-based Assays in human, mouse, rat CACNA1I
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1I

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CACNA1I gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cacna1i1 , 5 calcium channel, voltage-dependent, alpha 1I subunit1, 5 87.97(n)1
    93.7(a)1
      15 (37.85 cM)5
    2395561  NM_001044308.21  NP_001037773.21 
     802872385 
    chicken
    (Gallus gallus)
    Aves CACNA1I1 calcium channel, voltage-dependent, T type, alpha 1I more 76.82(n)
    82.08(a)
      427900  XM_425474.3  XP_425474.3 
    lizard
    (Anolis carolinensis)
    Reptilia CACNA1I6
    calcium channel, voltage-dependent, T type, alpha ...
    73(a)
    1 ↔ 1
    5(25191713-25379833)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cacna1i1 calcium channel, voltage-dependent, T type, alpha 1I more 70.63(n)
    77.94(a)
      100494599  XM_002933757.2  XP_002933803.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cacna1i1 calcium channel, voltage-dependent, T type, alpha 1I more 67.93(n)
    70.47(a)
      566351  XM_689623.5  XP_694715.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta cac6
    cacophony
    22(a)
    many ↔ many
    X(11825982-11879120)
    worm
    (Caenorhabditis elegans)
    Secernentea cca-13 Skeletal muscle calcium channel alpha-1
    subunit
    56(a)   X(7884813-7896426)   --


    ENSEMBL Gene Tree for CACNA1I (if available)
    TreeFam Gene Tree for CACNA1I (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CACNA1I gene
    SCN5A2  SCN3A2  SCN9A2  CACNA1D2  SCN7A2  SCN2A2  CACNA1F2  CACNA1H2  
    CACNA1C2  CACNA1S2  SCN11A2  CACNA1G2  SCN4A2  SCN8A2  SCN1A2  SCN10A2  
    6 SIMAP similar genes for CACNA1I using alignment to 3 protein entries:     CAC1I_HUMAN (see all proteins):
    SCN3A    SCN5A    CACNA1H    SCN4A    CACNA1G    SCN9A

    Find genes that share paralogs with CACNA1I           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CACNA1I (see all 2816)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929225571,2
    --39965087(+) AGGCCC/TTGGGA 2 -- us2k10--------
    rs1823785591,2
    --39965128(+) GGTTGC/TGGAGG 2 -- us2k10--------
    rs792334491,2
    C,F--39965151(+) GAGGGC/TACCAT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1870110681,2
    --39965205(+) GGCCTC/TTCAAC 2 -- us2k10--------
    rs1918542001,2
    --39965265(+) TGTTCA/TCTTGG 2 -- us2k10--------
    rs1507095691,2
    --39965286(+) TTCACC/TTGCCA 2 -- us2k10--------
    rs1378882841,2
    --39965393(+) TGCATC/TACCTA 2 -- us2k10--------
    rs57577281,2
    C--39965471(+) CTAAAG/ACAAGT 2 -- us2k14Minor allele frequency- A:0.39NA WA EA 360
    rs1835743761,2
    --39965606(+) CTGGAA/GTGCAG 2 -- us2k10--------
    rs556843831,2
    C,F--39965699(+) ACAGCG/ATGTGC 2 -- us2k15Minor allele frequency- A:0.18WA NA EA 362

    HapMap Linkage Disequilibrium report for CACNA1I (39966758 - 40085742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CACNA1I:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724258CNV Deletion23290073
    esv2724257CNV Deletion23290073
    esv1010347CNV Deletion20482838
    esv2086990CNV Deletion18987734
    esv2724256CNV Deletion23290073
    nsv915106CNV Loss21882294
    dgv4976n71CNV Loss21882294
    nsv834200CNV Loss17160897
    nsv915099CNV Loss21882294
    dgv4975n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CACNA1I
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CACNA1I
    DNA2.0 Custom Variant and Variant Library Synthesis for CACNA1I

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608230    OMIM disorders: --


    Find genes that share disorders with CACNA1I           About GenesLikeMe

    Genetic Association Database (GAD): CACNA1I
    Human Genome Epidemiology (HuGE) Navigator: CACNA1I (2 documents)

    Export disorders for CACNA1I gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CACNA1I gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with CACNA1I)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit. (PubMed id 10454147)1, 2, 3 Mittman S.... Agnew W.S. (Neurosci. Lett. 1999)
    2. Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. (PubMed id 16740636)1, 2, 9 Zhang D.... Gopalakrishnan M. (J. Biol. Chem. 2006)
    3. CACNA1I is not associated with childhood absence epilepsy in the Chinese Han population. (PubMed id 16939858)1, 4 Wang J....Wu X. (Pediatr. Neurol. 2006)
    4. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. (PubMed id 16382099)1, 3 Catterall W.A....Striessnig J. (Pharmacol. Rev. 2005)
    5. Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. (PubMed id 12080115)1, 2 Gomora J.C.... Perez-Reyes E. (Biophys. J. 2002)
    6. Specific properties of T-type calcium channels generated by the human alpha1I subunit. (PubMed id 10749850)1, 2 Monteil A.... Nargeot J. (J. Biol. Chem. 2000)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    8. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    9. Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors. (PubMed id 17535809)1, 9 Hildebrand M.E....Snutch T.P. (J. Biol. Chem. 2007)
    10. Functional impact of alternative splicing of human T-type Cav3.3 calcium channels. (PubMed id 15254077)1, 9 MurbartiA!n J....Perez-Reyes E. (J. Neurophysiol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8911 HGNC: 1396 AceView: CACNA1I Ensembl:ENSG00000100346 euGenes: HUgn8911
    ECgene: CACNA1I Kegg: 8911 H-InvDB: CACNA1I

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1120

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CACNA1I Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CACNA1I gene:
    Search GeneIP for patents involving CACNA1I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CACNA1I
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CACNA1I  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CACNA1I  
     OriGene qSTAR qPCR primer pairs in human, mouse for CACNA1I   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CACNA1I   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CACNA1I   OriGene Custom Protein Services for CACNA1I  

     
     
     Block miRNA regulation of human, mouse, rat CACNA1I using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CACNA1I
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CACNA1I Predesigned siRNA for gene silencing in human, mouse, rat CACNA1I
     QuantiFast Probe-based Assays in human, mouse, rat CACNA1I QuantiTect SYBR Green Assays in human, mouse, rat CACNA1I
     PCR Arrays including human, mouse, rat CACNA1I Search Chromatin IP Primers for CACNA1I
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CACNA1I  GeneGlobe Interaction Network for CACNA1I
     Regulatory tfbs in CACNA1I promoter
     GenScript Custom Purified and Recombinant Proteins Services for CACNA1I GenScript cDNA clones with any tag delivered in your preferred vector for CACNA1I
     GenScript Custom Assay Services for CACNA1I GenScript Custom overexpressing Cell Line Services for CACNA1I
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CACNA1I
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CACNA1I antibodies
     CACNA1I proteins
     Antibodies for CACNA1I
     See all of Abcam's Antibodies, Kits and Proteins for CACNA1I
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CACNA1I
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1I
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CACNA1I
     SwitchGear Promoter luciferase reporter plasmids for CACNA1I
     ThermoFisher Antibodies for CACNA1I
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1I
     Browse compounds at ApexBio
     Addgene plasmids for CACNA1I
      Search eBioscience for proteins for CACNA1I
      Search eBioscience for elisas for CACNA1I
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CACNA1I
     antibodies-online antibodies for CACNA1I (15 products)
     antibodies-online kits for CACNA1I (4 products)
     antibodies-online peptides for CACNA1I
     antibodies-online proteins for CACNA1I (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CACNA1I gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4