Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CACNA1G Gene

Aliases for CACNA1G Gene

  • Calcium Channel, Voltage-Dependent, T Type, Alpha 1G Subunit 2 3
  • Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 3 4
  • Cav3.1c 3 4
  • NBR13 3 4
  • Voltage-Dependent T-Type Calcium Channel Alpha 1G Subunit 3
  • Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G 3
  • Voltage-Dependent Calcium Channel Alpha 1G Subunit 3
  • Ca(V)T.1 3
  • KIAA1123 4
  • Cav3.1 3

External Ids for CACNA1G Gene

Previous GeneCards Identifiers for CACNA1G Gene

  • GC17P048351
  • GC17P051119
  • GC17P048980
  • GC17P049113
  • GC17P045993
  • GC17P048639
  • GC17P044006

Summaries for CACNA1G Gene

Entrez Gene Summary for CACNA1G Gene

  • Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for CACNA1G Gene

CACNA1G (Calcium Channel, Voltage-Dependent, T Type, Alpha 1G Subunit) is a Protein Coding gene. Diseases associated with CACNA1G include colorectal cancer. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include scaffold protein binding and low voltage-gated calcium channel activity. An important paralog of this gene is CACNA1D.

UniProtKB/Swiss-Prot for CACNA1G Gene

  • Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes

Tocris Summary for CACNA1G Gene

  • Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Gene Wiki entry for CACNA1G Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA1G Gene

Genomics for CACNA1G Gene

Regulatory Elements for CACNA1G Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACNA1G Gene

Start:
50,561,068 bp from pter
End:
50,629,625 bp from pter
Size:
68,558 bases
Orientation:
Plus strand

Genomic View for CACNA1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNA1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA1G Gene

Proteins for CACNA1G Gene

neXtProt entry for CACNA1G Gene

Proteomics data for CACNA1G Gene at MOPED

Post-translational modifications for CACNA1G Gene

  • In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II
  • Glycosylation at Asn173, Asn246, Asn306, Asn310, Asn322, Asn1448, Asn1451, and Asn1698
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CACNA1G Gene

Domains for CACNA1G Gene

Gene Families for CACNA1G Gene

HGNC:
  • CACN :Calcium channel subunits
  • CACN1 :Voltage-gated ion channels / Calcium channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O43497

UniProtKB/Swiss-Prot:

CAC1G_HUMAN :
  • O43497
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position
  • The linker region between repeat III and IV probably plays a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane by interfering with or restricting its lateral diffusion
Family:
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily.
genes like me logo Genes that share domains with CACNA1G: view

Function for CACNA1G Gene

Molecular function for CACNA1G Gene

GENATLAS Biochemistry: calcium low activated (LVA) voltage-gated channel,T (fast inactivation,small conductance) type, neuronal alpha 1G subunit,predominantly expressed in brain,aberrantly methylated and inactivated in cancer,colon,gastric carcinomas and in leukemia
UniProtKB/Swiss-Prot Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes

Gene Ontology (GO) - Molecular Function for CACNA1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005244 voltage-gated ion channel activity --
GO:0005245 voltage-gated calcium channel activity --
GO:0005515 protein binding --
GO:0008332 low voltage-gated calcium channel activity IDA 21084288
genes like me logo Genes that share ontologies with CACNA1G: view
genes like me logo Genes that share phenotypes with CACNA1G: view

Animal Models for CACNA1G Gene

MGI Knock Outs for CACNA1G:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CACNA1G Gene

Localization for CACNA1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA1G Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNA1G Gene COMPARTMENTS Subcellular localization image for CACNA1G gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CACNA1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CACNA1G: view

Pathways for CACNA1G Gene

genes like me logo Genes that share pathways with CACNA1G: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CACNA1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential --
GO:0002027 regulation of heart rate IEA --
GO:0006810 transport TAS 9495342
GO:0006811 ion transport --
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with CACNA1G: view

Compounds for CACNA1G Gene

(5) Tocris Compounds for CACNA1G Gene

Compound Action Cas Number
Isradipine Ca2+ channel blocker (L-type) [75695-93-1]
Mibefradil dihydrochloride Ca2+ channel blocker (T-type) [116666-63-8]
omega-Conotoxin GVIA Ca2+ channel blocker (N-type) [106375-28-4]
Pregabalin Anticonvulsant; selectively binds the alpha2delta subunit of voltage-sensitive calcium channels [148553-50-8]
SNX 482 Potent and selective CaV2.3 blocker (R-type) [203460-30-4]

(2) HMDB Compounds for CACNA1G Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Verapamil
  • Akilen
52-53-9

(8) Drugbank Compounds for CACNA1G Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cinnarizine
298-57-7 target inhibitor
Ethosuximide
  • Aethosuximide
77-67-8 target inhibitor
Flunarizine
  • (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine
52468-60-7 target inhibitor
Methsuximide
  • (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion
77-41-8 target inhibitor
Mibefradil
116644-53-2 target inhibitor

(5) IUPHAR Ligand for CACNA1G Gene

Ligand Type Action Affinity Pubmed IDs
mibefradil Pore Blocker Antagonist 6.8
anandamide Channel blocker None
SB209712 Channel blocker None
kurtoxin Channel blocker None
Ni2+ Channel blocker None

(4) Novoseek inferred chemical compound relationships for CACNA1G Gene

Compound -log(P) Hits PubMed IDs
o6-methylguanine 52.2 2
calcium 38.7 16
retinoic acid 28.5 4
estrogen 0 2
genes like me logo Genes that share compounds with CACNA1G: view

Transcripts for CACNA1G Gene

Unigene Clusters for CACNA1G Gene

Calcium channel, voltage-dependent, T type, alpha 1G subunit:
Representative Sequences:

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CACNA1G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^
SP1: - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CACNA1G Gene

GeneLoc Exon Structure for
CACNA1G
ECgene alternative splicing isoforms for
CACNA1G

Expression for CACNA1G Gene

mRNA expression in normal human tissues for CACNA1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNA1G Gene

This gene is overexpressed in Brain - Cerebellum (8.2) and Brain - Cortex (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNA1G Gene

SOURCE GeneReport for Unigene cluster for CACNA1G Gene Hs.591169

mRNA Expression by UniProt/SwissProt for CACNA1G Gene

O43497-CAC1G_HUMAN
Tissue specificity: Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression
genes like me logo Genes that share expressions with CACNA1G: view

In Situ Assay Products

Orthologs for CACNA1G Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACNA1G 35
  • 98.73 (n)
  • 98.58 (a)
CACNA1G 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACNA1G 35
  • 91.45 (n)
  • 94.47 (a)
CACNA1G 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNA1G 35
  • 92.31 (n)
  • 95.18 (a)
CACNA1G 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacna1g 35
  • 89.48 (n)
  • 94.73 (a)
Cacna1g 16
Cacna1g 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACNA1G 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNA1G 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacna1g 35
  • 89.13 (n)
  • 94.01 (a)
chicken
(Gallus gallus)
Aves CACNA1G 35
  • 75.3 (n)
  • 76.58 (a)
CACNA1G 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNA1G 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacna1g 35
  • 68.96 (n)
  • 73.54 (a)
zebrafish
(Danio rerio)
Actinopterygii cacna1g 35
  • 66.59 (n)
  • 67.79 (a)
cacna1g 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ca-alpha1T 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cca-1 36
  • 46 (a)
OneToMany
cca-1 37
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for CACNA1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACNA1G Gene

ENSEMBL:
Gene Tree for CACNA1G (if available)
TreeFam:
Gene Tree for CACNA1G (if available)

Paralogs for CACNA1G Gene

Selected SIMAP similar genes for CACNA1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CACNA1G: view

Variants for CACNA1G Gene

Sequence variations from dbSNP and Humsavar for CACNA1G Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs107067 -- 50,577,581(+) tgcga(A/T)gtgaa intron-variant
rs189902 -- 50,594,237(-) TGTGA(A/T)TGATA intron-variant
rs198530 -- 50,600,964(+) AGGGC(A/T)CTGGA intron-variant
rs198533 -- 50,595,925(+) GAAGT(A/G)TGTAA intron-variant
rs198538 -- 50,565,332(+) ACCCA(C/T)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNA1G Gene

Variant ID Type Subtype PubMed ID
nsv908600 CNV Gain 21882294
dgv3229n71 CNV Loss 21882294
nsv833477 CNV Loss 17160897
dgv3230n71 CNV Loss 21882294
nsv908605 CNV Loss 21882294
nsv908608 CNV Loss 21882294
dgv42n68 CNV Loss 17160897
esv989095 CNV Insertion 20482838
nsv111873 CNV Insertion 16902084
esv1506174 CNV Insertion 17803354
nsv111816 CNV Insertion 16902084

Relevant External Links for CACNA1G Gene

HapMap Linkage Disequilibrium report
CACNA1G
Human Gene Mutation Database (HGMD)
CACNA1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA1G Gene

Disorders for CACNA1G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CACNA1G Gene including...

Search for CACNA1G Gene in MalaCards »

(1) University of Copenhagen DISEASES for CACNA1G Gene

(6) Novoseek inferred disease relationships for CACNA1G Gene

Disease -log(P) Hits PubMed IDs
microsatellite instability 89.6 2
colorectal cancer 76.5 11
tumors 46.3 9
colorectal carcinoma 30.8 2
cancer 30 1

Relevant External Links for CACNA1G

Genetic Association Database (GAD)
CACNA1G
Human Genome Epidemiology (HuGE) Navigator
CACNA1G
genes like me logo Genes that share disorders with CACNA1G: view

No data available for UniProtKB/Swiss-Prot for CACNA1G Gene

Publications for CACNA1G Gene

  1. Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels. (PMID: 10692398) Monteil A. … Nargeot J. (J. Biol. Chem. 2000) 3 4 23 25
  2. Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. (PMID: 17397049) Singh B. … Yamakawa K. (Hum. Mutat. 2007) 3 23 48
  3. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. (PMID: 9495342) Perez-Reyes E. … Lee J.-H. (Nature 1998) 2 3 4
  4. Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain. (PMID: 10648811) Cribbs L.L. … Perez-Reyes E. (FEBS Lett. 2000) 3 4 23
  5. Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit. (PMID: 10548410) Mittman S. … Agnew W.S. (Neurosci. Lett. 1999) 3 4 23

Products for CACNA1G Gene

  • antibodies-online peptides for CACNA1G
  • antibodies-online antibodies for CACNA1G
  • antibodies-online kits for CACNA1G

Sources for CACNA1G Gene

Back to Top

Content