CACNA1G Gene
protein-coding GIFtS : 68 GCID: GC17 P048639
calcium channel, voltage-dependent, T type, alpha 1G subunit
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Aliasesfor CACNA1G gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Calcium Channel, Voltage-Dependent, T Type, Alpha 1G Subunit 1 2 Cav3.1c3 NBR131 2 3 Voltage-Dependent Calcium Channel Alpha 1G Subunit2 Cav3.11 2 Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G2 Voltage-Gated Calcium Channel Subunit Alpha Cav3.12 3 Cav3.1c3 Ca(V)T.12 KIAA11233
Export aliases for CACNA1G gene to outside databases Previous GC identifers: GC17P048351 GC17P051119 GC17P048980 GC17P049113 GC17P045993 GC17P044006
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Summariesfor CACNA1G gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CACNA1G : Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Sep 2011) UniProtKB/Swiss-Prot: CAC1G_HUMAN, O43497 Function : Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are alsoinvolved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes summary
for CACNA1G : Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calciuminflux in response to depolarisation. They regulate intracellular processes such as contraction, secretion,neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinctsubunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore andgating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types ofvoltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families.Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activateddihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type). Gene Wiki entry for CACNA1G
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Genomic Viewsfor CACNA1G gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CACNA1G gene promoter:E2F-3a E2F-4 E2F-5 Sp1 p300 E2F-2 E2F-1 E2F COMP1 HOXA5 Other transcription factors Search SABiosciences Chromatin IP Primers for CACNA1G Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q22 CACNA1G Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P048639: view genomic region
(about GC identifiers )
Start: 48,638,429 bp from pter End:
48,704,835 bp from pter
Size: 66,407 bases Orientation:
plus strand
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Proteinsfor CACNA1G gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CAC1G_HUMAN, O43497 See
protein sequence )Recommended Name: Size : 2377 amino acids; 262472 DaSubcellular location : Membrane; Multi-pass membrane proteinSecondary accessions : O43498 O94770 Q9NYU4 Q9NYU5 Q9NYU6 Q9NYU7 Q9NYU8 Q9NYU9 Q9NYV0 Q9NYV1 Q9UHN9Q9UHP0 Q9ULU6 Q9UNG7 Q9Y5T2 Q9Y5T3 Alternative splicing : 13 isoforms : O43497-1 O43497-2 O43497-3 O43497-4 O43497-5 O43497-6 O43497-7 O43497-8 O43497-9 O43497-10 O43497-11 O43497-12 O43497-13 Explore the universe of human proteins at neXtProt for CACNA1G: NX_O43497 Post-translational modifications:
In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O43497 CACNA1G Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (28 alternative transcripts): NP_001243253.1 NP_001243254.1 NP_001243255.1 NP_001243256.1 NP_001243257.1 NP_001243258.1 NP_001243259.1 NP_001243260.1 NP_001243261.1 NP_001243262.1 NP_001243263.1 NP_001243288.1 NP_001243289.1 NP_001243290.1 NP_061496.2 NP_938190.1 NP_938191.2 NP_938192.1 NP_938193.1 NP_938194.1 NP_938196.1 NP_938197.1 NP_938198.1 NP_938199.1 NP_938200.1 NP_938201.1 NP_938202.1 NP_938406.1 ENSEMBL proteins: ENSP00000353990 ENSP00000339302 ENSP00000409759 ENSP00000392390 ENSP00000425522 ENSP00000426261 ENSP00000425451 ENSP00000422407 ENSP00000426814 ENSP00000427238 ENSP00000423112 ENSP00000427247 ENSP00000420918 ENSP00000426313 ENSP00000425153 ENSP00000426172 ENSP00000423045 ENSP00000427231 ENSP00000427173 ENSP00000426098 ENSP00000425698 ENSP00000426232 ENSP00000423317 ENSP00000421518 ENSP00000424664 ENSP00000422268 ENSP00000426558 ENSP00000423155 ENSP00000414388 ENSP00000352011 ENSP00000350979 ENSP00000459988 ENSP00000427697 ENSP00000347078 Reactome Protein details: O43497 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing CACNA1G Antibody Products: Assay Products for CACNA1G:
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Protein
Domains /for CACNA1G gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O43497 ProtoNet protein and cluster: O43497
1 Blocks protein family : IPB005445 UniProtKB/Swiss-Prot: CAC1G_HUMAN, O43497 Domain : Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and onepositively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position Domain : The linker region between repeat III and IV probably play a role in the inactivation of the channel. TheC-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion Similarity : Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily
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Functionfor CACNA1G gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CAC1G_HUMAN, O43497 Function : Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are alsoinvolved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes
Genatlas biochemistry entry for CACNA1G calcium low activated (LVA) voltage-gated channel,T (fast inactivation,small conductance) type, neuronal alpha 1G subunit,predominantly expressed in brain,aberrantly methylated and inactivated in cancer,colon,gastric carcinomas and in leukemia Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 19 )human mouse rat see all 15 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 15 ): CACNA1G (NM_198376 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNA1G Vector BioLabs ready-to-use adenovirus/AAV for human mouse , rat CACNA1G
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1G
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005216 ion channel activity
-- -- GO:0005245 voltage-gated calcium channel activity
-- -- GO:0008332 low voltage-gated calcium channel activity
IDA -- GO:0097110 scaffold protein binding
IPI --
About GeneDecksing 3 GenomeRNAi human phenotypes for CACNA1G :Animal Models: Cacna1g tm1.1Stl Cacna1g tm1.1Abp Cacna1g tm1Hssh Cacna1g tm1Dgen 6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cacna1g) :About GeneDecksing
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Pathways & Interactionsfor CACNA1G gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/27 super-pathways (see all 27 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 DREAM Repression and Dynorphin Expression 2 PKC-Theta Pathway 3 Sweet Taste Signaling 4 Activation of cAMP-Dependent PKA 5 NFAT and Cardiac Hypertrophy
Pathway sources See GeneCards unified pathways Show all pathways 3 5/37 (see all 37 )1 2 4 3 CACNA1G 3 (Kegg details for CACNA1G) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CACNA1G STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/51 Interacting proteins for CACNA1G (O43497 2 , 3 ENSP00000352011 4 via UniProtKB, MINT, STRING , and/or I2D (see all 51 )About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing
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Drugs & Compoundsfor CACNA1G gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for CACNA1G available from Tocris Bioscience About this table 2 HMDB Compounds for CACNA1G About this table 8 DrugBank Compounds for CACNA1G About this table 4 Novoseek chemical compound relationships for CACNA1G gene About this table CACNA1G / CAC1G
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Transcriptsfor CACNA1G gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CACNA1G gene (29 alternative transcripts): NM_001256324.1 NM_001256325.1 NM_001256326.1 NM_001256327.1 NM_001256328.1 NM_001256329.1 NM_001256330.1 NM_001256331.1 NM_001256332.1 NM_001256333.1 NM_001256334.1 NM_001256359.1 NM_001256360.1 NM_001256361.1 NM_018896.4 NM_198376.2 NM_198377.2 NM_198378.2 NM_198379.2 NM_198380.2 NM_198382.2 NM_198383.2 NM_198384.2 NM_198385.2 NM_198386.2 NM_198387.2 NM_198388.2 NM_198396.2 NM_198397.1 Unigene Cluster for CACNA1G:
Calcium channel, voltage-dependent, T type, alpha 1G subunit Hs.591169 [show with all ESTs ] Unigene Representative Sequence: NM_018896 18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34 ): ENST00000360761 ENST00000352832 (uc002iro.1 ) ENST00000442258 ENST00000416767 (uc002iri.1 )ENST00000502264 ENST00000512389 ENST00000513964 ENST00000514717 ENST00000510366 ENST00000503485 ENST00000507510 ENST00000511765 ENST00000507336 ENST00000506406 ENST00000504076 ENST00000513689 ENST00000507609 ENST00000503436 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 19 )human mouse rat see all 15 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 15 ): CACNA1G (NM_198376 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CACNA1G Vector BioLabs ready-to-use adenovirus/AAV for human mouse , rat CACNA1G
Additional cDNA sequence: AB012043.1 AB032949.2 AF029229.1 AF124351.1 AF126965.1 AF126966.1 AF134985.1 AF134986.1 AF190860.1 AF227744.1 AF227745.1 AF227746.1 AF227747.1 AF227748.1 AF227749.1 AF227750.1 AF227751.1 AK296513.1 BC110995.1 NR_046054.1 NR_046055.1 NR_046056.1 NR_046057.1 NR_046058.1
21 DOTS entries : DT.101984766 DT.101984767
DT.91706999 DT.120971118 DT.95164735 DT.102836581 DT.120971099 DT.100782948 DT.40130397 DT.100782947 DT.120971107 DT.91707040 DT.91707005 DT.120971061 DT.454910 DT.95164733 DT.120971068 DT.120971058 DT.120971064 DT.120971132 DT.97840220 24/79 AceView cDNA sequences (see all 79 ):
NM_198377 NM_018896 AF227751 AA716563 AF227747 NM_198397 AF134986 NM_198379 AF227745 AF126966 NM_198384 NM_198383 NM_198380 NM_198388 AF124351 AF227748 NM_198396 AF126965 AB032949 NM_198387 AF227746 NM_198376 AF134985 AF227750 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1G (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ SP1 : - - - SP2 : SP3 : - SP4 : - SP5 : -
ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b SP1 : - SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for CACNA1G
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Expression for CACNA1G gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CACNA1G expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGCCTCGC
About this image CACNA1G expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage Expression: Experimental details:
In-situ hybridization
See CACNA1G Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CACNA1G SOURCE GeneReport for Unigene cluster: Hs.591169 UniProtKB/Swiss-Prot: CAC1G_HUMAN, O43497 Tissue specificity : Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum andthalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression SABiosciences Expression via Pathway-Focused PCR Array including CACNA1G : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1G
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Orthologsfor CACNA1G gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CACNA1G gene from 5/20 species (see all 20 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves CACNA1G1
calcium channel, voltage-dependent, T type, alpha 1G more
75.37(n) 76.77(a)
769385 XM_001232653.2 XP_001232654.2
lizard Reptilia CACNA1G6
--
71(a)
1 ↔ 1
2(116960712-117171516)
zebrafish Actinopterygii cacna1g1
calcium channel, voltage-dependent, T type, alpha 1G more
66.76(n) 68.7(a)
563904 XM_001920515.3 XP_001920550.3
fruit fly Insecta Ca-alpha1T3
calcium channel
54(a)
--
worm Secernentea cca-13
Skeletal muscle calcium channel alpha-1
58(a)
X(7884813-7896426) --
ENSEMBL Gene Tree for CACNA1G (if available)TreeFam Gene Tree for CACNA1G (if available)
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Paralogsfor CACNA1G gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CACNA1G gene CACNA1A 2 SCN5A 2 SCN9A 2 CACNA1D 2 CACNA1I 2 SCN7A 2 CACNA1F 2 SCN8A 2 SCN10A 2 SCN3A 2 CACNA1E 2 SCN2A 2 CACNA1H 2 CACNA1S 2 CACNA1C 2 SCN11A 2 SCN4A 2 SCN1A 2 CACNA1B 2 9 SIMAP similar genes for CACNA1G using alignment to 34 protein entries: CAC1G_HUMAN (see all proteins ):CACNA1H SCN5A CACNA1I CACNA1E SCN4A SCN3A CACNA1A CACNA1B CACNA1C About GeneDecksing
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Genomic Variantsfor CACNA1G gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CACNA1G (48638429 - 48704835 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CACNA1G 1 CNV 5017 Human Gene Mutation Database (HGMD) : CACNA1G SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor CACNA1G gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 604065
OMIM disorders : --20 : About MalaCards childhood absence epilepsy absence epilepsy idiopathic generalized epilepsy generalized epilepsy pancreatic endocrine tumors acute myeloid leukemia neuronitis myeloid leukemia squamous cell carcinoma colorectal cancer duodenitis colon cancer pharyngitis retinoblastoma leukemia carcinoma pancreatitis ataxia melanoma adenocarcinoma 1 disease from the University of Copenhagen DISEASES database for CACNA1G :Colorectal cancer 6 Novoseek disease relationships for CACNA1G gene About this table
Human Genome Epidemiology (HuGE) Navigator: CACNA1G (9 documents) Export disorders for CACNA1G gene to outside databases
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Publicationsfor CACNA1G gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CACNA1G gene, integrated from 9 sources (see all 107 ):(articles sorted by number of sources associating them with CACNA1G) Utopia : connect your pdf to the dynamic
Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels. (PubMed id 10692398) 1 , 2 , 7, 9(2000) Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. (PubMed id 9495342) 1 , 2 , 3(1998) Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors. (PubMed id 10493502) 1 , 2 , 9(1999) Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain. (PubMed id 10648811) 1 , 2 , 9(2000) Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit. (PubMed id 10548410) 1 , 2 , 9(1999) International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. (PubMed id 16382099) 1 , 3(2005) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954) 1 , 2 (2002) Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461) 1 , 2 (1999) Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. (PubMed id 17397049) 1 , 9(2007) Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. (PubMed id 17591929) 1 , 9(2007)
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External Searches for CACNA1G gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CACNA1G gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CACNA1G gene
(According to HUGE )
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Specialized Databases showing CACNA1G gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CACNA1G gene: CACNA1G GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CACNA1G gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CACNA1G OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CACNA1G OriGene 3'-UTR Clone for CACNA1G OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CACNA1G OriGene Custom Protein Services for CACNA1G OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNA1G QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1G
ThermoFisher Antibodies for CACNA1G
Vector BioLabs ready-to-use adenovirus/AAV for human mouse , rat CACNA1G
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summary
for 
GeneGo (Thomson Reuters) Pathway for CACNA1G
BioSystems Pathways for CACNA1G 
Reactome Pathways for CACNA1G
PharmGKB Pathways for 
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
