Aliases for CACNA1E Gene
- Calcium Voltage-Gated Channel Subunit Alpha1 E 2 3 5
- Brain Calcium Channel II 3 4
- CACNL1A6 3 4
- CACH6 3 4
- BII 3 4
- Calcium Channel, Voltage-Dependent, R Type, Alpha 1E Subunit 2
- Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1E 3
- Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 6 4
- Calcium Voltage-Gated Channel Subunit Alpha1 Subunit E 2
External Ids for CACNA1E Gene
Previous HGNC Symbols for CACNA1E Gene
Previous GeneCards Identifiers for CACNA1E Gene
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
GeneCards Summary for CACNA1E Gene
CACNA1E (Calcium Voltage-Gated Channel Subunit Alpha1 E) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is CACNA1A.
UniProtKB/Swiss-Prot for CACNA1E Gene
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.