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Aliases for CACNA1D Gene

Aliases for CACNA1D Gene

  • Calcium Voltage-Gated Channel Subunit Alpha1 D 2 3
  • Calcium Channel, Voltage-Dependent, L Type, Alpha 1D Subunit 2 3 5
  • CACNL1A2 3 4
  • CCHL1A2 3 4
  • CACH3 3 4
  • CACN4 3 4
  • Calcium Channel, Neuroendocrine/Brain-Type, Alpha 1 Subunit 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 2 4
  • Voltage-Gated Calcium Channel Alpha Subunit Cav1.3 3
  • Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 4
  • Voltage-Gated Calcium Channel Alpha 1 Subunit 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide 3
  • Cav1.3 3
  • PASNA 3
  • SANDD 3

External Ids for CACNA1D Gene

Previous HGNC Symbols for CACNA1D Gene

  • CCHL1A2
  • CACNL1A2

Previous GeneCards Identifiers for CACNA1D Gene

  • GC03P052645
  • GC03P052780
  • GC03P053383
  • GC03P053486

Summaries for CACNA1D Gene

Entrez Gene Summary for CACNA1D Gene

  • Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for CACNA1D Gene

CACNA1D (Calcium Voltage-Gated Channel Subunit Alpha1 D) is a Protein Coding gene. Diseases associated with CACNA1D include Sinoatrial Node Dysfunction And Deafness and Primary Aldosteronism, Seizures, And Neurologic Abnormalities. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). GO annotations related to this gene include ion channel activity and ankyrin binding. An important paralog of this gene is CACNA1A.

UniProtKB/Swiss-Prot for CACNA1D Gene

  • Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

Tocris Summary for CACNA1D Gene

  • Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

Gene Wiki entry for CACNA1D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA1D Gene

Genomics for CACNA1D Gene

Regulatory Elements for CACNA1D Gene

Enhancers for CACNA1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CACNA1D on UCSC Golden Path with GeneCards custom track

Promoters for CACNA1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CACNA1D on UCSC Golden Path with GeneCards custom track

Genomic Location for CACNA1D Gene

Chromosome:
3
Start:
53,494,656 bp from pter
End:
53,813,733 bp from pter
Size:
319,078 bases
Orientation:
Plus strand

Genomic View for CACNA1D Gene

Genes around CACNA1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACNA1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACNA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA1D Gene

Proteins for CACNA1D Gene

  • Protein details for CACNA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01668-CAC1D_HUMAN
    Recommended name:
    Voltage-dependent L-type calcium channel subunit alpha-1D
    Protein Accession:
    Q01668
    Secondary Accessions:
    • B0FYA3
    • Q13916
    • Q13931
    • Q71UT1
    • Q9UDC3

    Protein attributes for CACNA1D Gene

    Size:
    2161 amino acids
    Molecular mass:
    245141 Da
    Quaternary structure:
    • Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Channel activity is further modulated, depending on the presence of specific delta subunit isoforms. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CACNA1D Gene

    Alternative splice isoforms for CACNA1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNA1D Gene

Proteomics data for CACNA1D Gene at MOPED

Post-translational modifications for CACNA1D Gene

  • Glycosylation at Asn 155, Asn 225, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for CACNA1D Gene

No data available for DME Specific Peptides for CACNA1D Gene

Domains & Families for CACNA1D Gene

Gene Families for CACNA1D Gene

Graphical View of Domain Structure for InterPro Entry

Q01668

UniProtKB/Swiss-Prot:

CAC1D_HUMAN :
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
genes like me logo Genes that share domains with CACNA1D: view

Function for CACNA1D Gene

Molecular function for CACNA1D Gene

GENATLAS Biochemistry:
transverse tubule (TT) calcium voltage-gated channel (VDCC),L type,alpha 1D subunit,175kDa,dihydropyridine (DHP) sensitive,isoform 2,neuroendocrine/brain
UniProtKB/Swiss-Prot Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

Gene Ontology (GO) - Molecular Function for CACNA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential IMP 21131953
genes like me logo Genes that share ontologies with CACNA1D: view
genes like me logo Genes that share phenotypes with CACNA1D: view

Human Phenotype Ontology for CACNA1D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CACNA1D Gene

MGI Knock Outs for CACNA1D:

Animal Model Products

miRNA for CACNA1D Gene

miRTarBase miRNAs that target CACNA1D

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CACNA1D Gene

Localization for CACNA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA1D Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNA1D Gene COMPARTMENTS Subcellular localization image for CACNA1D gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CACNA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005891 voltage-gated calcium channel complex IEA,IDA 11160515
genes like me logo Genes that share ontologies with CACNA1D: view

Pathways & Interactions for CACNA1D Gene

genes like me logo Genes that share pathways with CACNA1D: view

Gene Ontology (GO) - Biological Process for CACNA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IDA 11160515
GO:0007411 axon guidance TAS --
GO:0050796 regulation of insulin secretion TAS --
GO:0051928 positive regulation of calcium ion transport IDA 1309651
genes like me logo Genes that share ontologies with CACNA1D: view

No data available for SIGNOR curated interactions for CACNA1D Gene

Drugs & Compounds for CACNA1D Gene

(48) Drugs for CACNA1D Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Felodipine Approved, Investigational Pharma Potentiation, Activator, blocker, Target, inhibitor 22
Nitrendipine Approved Pharma Inhibition, Pore Blocker, blocker, Target, inhibitor Calcium channel blocker 5
Isradipine Approved Pharma Gating inhibitor, blocker, Target, inhibitor 12
Verapamil Approved Pharma Channel blocker, blocker, Target, inhibitor 122
Amlodipine Approved Pharma blocker, Target, inhibitor Calcium channel blocker 458

(6) Additional Compounds for CACNA1D Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-Desmethylverapamil (D-702)
(+-)-Bay K 8644
71145-03-4
(S)-(-)-Bay K 8644
98625-26-4
Flunarizine dihydrochloride
30484-77-6
FPL 64176
120934-96-5

(5) Tocris Compounds for CACNA1D Gene

Compound Action Cas Number
(+-)-Bay K 8644 Ca2+ channel activator (L-type) 71145-03-4
(S)-(-)-Bay K 8644 Ca2+-channel activator (L-type) 98625-26-4
Flunarizine dihydrochloride Dual Na+/Ca2+ channel (T-type) blocker 30484-77-6
FPL 64176 Potent activator of Ca2+ channels (L-type) 120934-96-5
Nefiracetam Cognitive enhancer 77191-36-7

(29) ApexBio Compounds for CACNA1D Gene

Compound Action Cas Number
2-APB 524-95-8
Amlodipine Calcium channel blocker 88150-42-9
Amlodipine Besylate Block of L-type calcium channel 111470-99-6
Azelnidipine L-type calcium channel blocker;antihypertensive 123524-52-7
Benidipine HCl Calcium channel blocker 91599-74-5
Cilnidipine Blocker of Dual L- and N-type calcium channel 132203-70-4
Cinepazide maleate 26328-04-1
Clevidipine Butyrate 167221-71-8
Dehydroepiandrosterone (DHEA) Endogenous steroid hormone 53-43-0
Diltiazem HCl 33286-22-5
Felodipine 72509-76-3
Flunarizine 2HCl Calcium entry blocker 30484-77-6
Gabapentin HCl GABA analog 60142-95-2
Isradipine (Dynacirc) Calcium channel blocker 75695-93-1
Lacidipine L-type calcium channel blocker 103890-78-4
Lomerizine HCl 101477-54-7
Manidipine Calcium channel blocker 89226-50-6
Manidipine 2HCl 89226-75-5
Nicardipine HCl 54527-84-3
Nilvadipine 75530-68-6
Nisoldipine 63675-72-9
Nitrendipine Calcium channel blocker 39562-70-4
Ranolazine 2HCl Partial fatty acid oxidation inhibitor 95635-56-6
Strontium Ranelate 135459-87-9
Tetracaine HCl Anaesthetic and allosteric inhibitor 136-47-0
Tetrandrine 518-34-3
Thioridazine HCl Calcium channel protein inhibitor 130-61-0
Verapamil HCl 152-11-4
Zonisamide Antiepileptic with anticonvulsant and mechanistic effect 68291-97-4
genes like me logo Genes that share compounds with CACNA1D: view

Transcripts for CACNA1D Gene

Unigene Clusters for CACNA1D Gene

Calcium channel, voltage-dependent, L type, alpha 1D subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47
SP1:
SP2: -
SP3:

Relevant External Links for CACNA1D Gene

GeneLoc Exon Structure for
CACNA1D
ECgene alternative splicing isoforms for
CACNA1D

Expression for CACNA1D Gene

mRNA expression in normal human tissues for CACNA1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNA1D Gene

This gene is overexpressed in Pituitary (x4.4) and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CACNA1D Gene

This gene is overexpressed in Heart (48.9) and Urine (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CACNA1D Gene



SOURCE GeneReport for Unigene cluster for CACNA1D Gene Hs.476358

mRNA Expression by UniProt/SwissProt for CACNA1D Gene

Q01668-CAC1D_HUMAN
Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle.
genes like me logo Genes that share expression patterns with CACNA1D: view

Protein tissue co-expression partners for CACNA1D Gene

Primer Products

Orthologs for CACNA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNA1D 35
  • 92.6 (n)
  • 97.47 (a)
CACNA1D 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNA1D 35
  • 93.36 (n)
  • 97.19 (a)
CACNA1D 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacna1d 35
  • 91.07 (n)
  • 97.19 (a)
Cacna1d 16
Cacna1d 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNA1D 35
  • 99.58 (n)
  • 99.76 (a)
CACNA1D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacna1d 35
  • 90.36 (n)
  • 96.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNA1D 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNA1D 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACNA1D 35
  • 80.48 (n)
  • 88.22 (a)
CACNA1D 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cacna1da 35
  • 73 (n)
  • 79.81 (a)
cacna1da 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ca-alpha1D 37
  • 63 (a)
Ca-alpha1D 35
  • 62.11 (n)
  • 65.76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012434 35
  • 60.01 (n)
  • 63.68 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-19 37
  • 66 (a)
nca-1 37
  • 26 (a)
unc-2 37
  • 44 (a)
egl-19 35
  • 60.49 (n)
  • 64.33 (a)
Species with no ortholog for CACNA1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CACNA1D Gene

ENSEMBL:
Gene Tree for CACNA1D (if available)
TreeFam:
Gene Tree for CACNA1D (if available)

Paralogs for CACNA1D Gene

Paralogs for CACNA1D Gene

(11) SIMAP similar genes for CACNA1D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CACNA1D: view

Variants for CACNA1D Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA1D Gene

CAC1D_HUMAN-Q01668
A change from seven to eight ATG trinucleotide repeats, resulting in an additional N-terminal methionine, has been found in a patient with non-insulin-dependent diabetes mellitus (NIDDM).

Sequence variations from dbSNP and Humsavar for CACNA1D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs41276455 - 53,811,209(+) CCATC(A/G)ACGAG reference, missense
VAR_070868 Primary aldosteronism, seizures, and neurologic abnormalities (PASNA)
VAR_070869 Primary aldosteronism, seizures, and neurologic abnormalities (PASNA)
rs14165 -- 53,813,381(-) TGCCC(C/T)GTCGG downstream-variant-500B
rs709317 -- 53,575,583(-) CAATG(C/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNA1D Gene

Variant ID Type Subtype PubMed ID
esv2673204 CNV Deletion 23128226
esv2725284 CNV Deletion 23290073
nsv3826 CNV Insertion 18451855
nsv521276 CNV Loss 19592680
nsv520027 CNV Loss 19592680
nsv876803 CNV Loss 21882294
dgv283n21 CNV Loss 19592680
nsv876804 CNV Gain 21882294

Variation tolerance for CACNA1D Gene

Residual Variation Intolerance Score: 0.386% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACNA1D Gene

Human Gene Mutation Database (HGMD)
CACNA1D

Disorders for CACNA1D Gene

MalaCards: The human disease database

(6) MalaCards diseases for CACNA1D Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CAC1D_HUMAN
  • Primary aldosteronism, seizures, and neurologic abnormalities (PASNA) [MIM:615474]: A disorder characterized by hypertension, hypokalemia, and high aldosterone levels with low plasma renin activity and an elevated aldosterone/renin ratio. Other features include generalized seizures, cerebral palsy, spasticity, intellectual disability, and developmental delay. {ECO:0000269 PubMed:23913001}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sinoatrial node dysfunction and deafness (SANDD) [MIM:614896]: A disease characterized by congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia. {ECO:0000269 PubMed:21131953}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CACNA1D

Genetic Association Database (GAD)
CACNA1D
Human Genome Epidemiology (HuGE) Navigator
CACNA1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACNA1D
genes like me logo Genes that share disorders with CACNA1D: view

No data available for Genatlas for CACNA1D Gene

Publications for CACNA1D Gene

  1. The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. (PMID: 7557998) Yamada Y. … Seino Y. (Genomics 1995) 3 4 23 67
  2. Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. (PMID: 11160515) Bell D.C. … Dolphin A.C. (J. Neurophysiol. 2001) 3 25 26
  3. alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. (PMID: 11285265) Koschak A. … Striessnig J. (J. Biol. Chem. 2001) 3 25 26
  4. A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3. (PMID: 1664412) Chin H.M. … McBride O.W. (Genomics 1991) 2 3 23
  5. Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. (PMID: 20334460) Weant K.A. … Cook A.M. (Pharmacotherapy 2010) 25 26

Products for CACNA1D Gene

Sources for CACNA1D Gene

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