Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CACNA1D Gene

protein-coding   GIFtS: 62
GCID: GC03P053504

calcium channel, voltage-dependent, L type, alpha 1D subunit


(Previous symbols: CCHL1A2, CACNL1A2)
 Explore 17 diseases affiliated with
CACNA1D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CACNA1D    

Aliases
for CACNA1D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium Channel, Voltage-Dependent, L Type, Alpha 1D Subunit1 2     Calcium Channel, L Type, Alpha-1 Polypeptide2
CACNL1A21 2 3 5     Calcium Channel, Neuroendocrine/Brain-Type, Alpha 1 Subunit2
CCHL1A21 2 3 5     Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D2
CACH31 2 3     Voltage-Gated Calcium Channel Alpha 1 Subunit2
CACN41 2 3     Voltage-Gated Calcium Channel Alpha Subunit Cav1.32
Cav1.31 2     Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 23
SANDD2     Voltage-Gated Calcium Channel Subunit Alpha Cav1.33

External Ids:    HGNC: 13911   Entrez Gene: 7762   Ensembl: ENSG000001573887   OMIM: 1142065   UniProtKB: Q016683   

Export aliases for CACNA1D gene to outside databases

Previous GC identifers: GC03P052645 GC03P052780 GC03P053383 GC03P053486


Summaries
for CACNA1D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CACNA1D:
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a
variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene
expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits.
The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits
regulating this activity. The distinctive properties of the calcium channel types are related primarily to the
expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D
subunit. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Dec 2012)

UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also
involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter
release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type
calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are
blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA).
They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)

summary for CACNA1D:
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium
influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion,
neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct
subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and
gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of
voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families.
Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated
dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Gene Wiki entry for CACNA1D (Cav1.3)


Genomic Views
for CACNA1D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CACNA1D gene promoter:
         HOXA9   CREB   deltaCREB   Nkx2-5   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CACNA1D promoter sequence
   Search SABiosciences Chromatin IP Primers for CACNA1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNA1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p14.3

CACNA1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CACNA1D gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053504:  view genomic region     (about GC identifiers)

Start:
 53,528,683 bp from pter      End:
 53,846,492 bp from pter
Size:
 317,810 bases      Orientation:
 plus strand

Proteins
for CACNA1D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668 (See protein sequence)
Recommended Name: Voltage-dependent L-type calcium channel subunit alpha-1D  
Size: 2161 amino acids; 245141 Da
Subunit: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta
subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1
subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The
auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via
IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for CACNA1D:
3LV3 (3D)    
Secondary accessions: Q13916 Q13931 Q9UDC3
Alternative splicing: 2 isoforms:  Q01668-1   Q01668-2   

Explore the universe of human proteins at neXtProt for CACNA1D: NX_Q01668

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01668

    • CACNA1D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_000711.1  NP_001122311.1  NP_001122312.1  

    ENSEMBL proteins: 
     ENSP00000288133   ENSP00000288139   ENSP00000409174   ENSP00000418045   ENSP00000418014  
     ENSP00000438229   ENSP00000440956  
    Reactome Protein details: Q01668
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CACNA1D 
    GenScript Custom Purified and Recombinant Proteins Services for CACNA1D
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005891voltage-gated calcium channel complex IDA1309651
    GO:0030018Z disc ISS--


    CACNA1D for ontologies           About GeneDecksing



    CACNA1D Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CACNA1D
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CACNA1D 
    GenScript Custom Superior Antibodies Services for CACNA1D
    Novus Biologicals CACNA1D Antibodies
    Search for Antibodies for CACNA1D at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for CACNA1D

    Assay Products for CACNA1D: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CACNA1D
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CACNA1D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CACNA1D for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005446 VDCC_L_a1su
     IPR002077 VDCCAlpha1
     IPR014873 VDCC_a1su_IQ
     IPR005821 Ion_trans_dom
     IPR005452 LVDCC_a1dsu

    Graphical View of Domain Structure for InterPro Entry Q01668

    ProtoNet protein and cluster: Q01668

    3 Blocks protein families:
    IPB002077 Calcium channel signature
    IPB005446 L-type voltage-dependent calcium channel alpha-1 subunit signature
    IPB005452 Voltage-dependent L-type calcium channel alpha-1D subunit signature


    UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668
    Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one
    positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized
    by a series of positively charged amino acids at every third position
    Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily


    Function
    for CACNA1D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also
    involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter
    release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type
    calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are
    blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA).
    They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)

         Genatlas biochemistry entry for CACNA1D:
    transverse tubule (TT) calcium voltage-gated channel (VDCC),L type,alpha 1D subunit,175kDa,dihydropyridine (DHP)
    sensitive,isoform 2,neuroendocrine/brain

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): CACNA1D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNA1D
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate CACNA1D (see all 48):
    hsa-miR-607 hsa-miR-3146 hsa-let-7d hsa-miR-938 hsa-let-7a-2* hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CACNA1D 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNA1D (see all 7)
    OriGene shRNA RFP: CACNA1D
    OriGene siRNA: CACNA1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNA1D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CACNA1D

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CACNA1D (NM_001128839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNA1D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1D 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CACNA1D
    Search LifeMap BioReagents cell lines for CACNA1D

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1D

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005245voltage-gated calcium channel activity IDA--
    GO:0005515protein binding ----
    GO:0008331contributes to high voltage-gated calcium channel activity IDA1309651
    GO:0030506ankyrin binding ISS--
    GO:0046872metal ion binding IEA--


    CACNA1D for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CACNA1D: Cacna1dtm1Hssh Cacna1dtm1Jst
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cacna1d):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system 

    CACNA1D for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CACNA1D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DREAM Repression and Dynorphin Expression
    		DREAM Repression and Dynorphin Expression1.00
    		Caspase Cascade0.24
    		BMP Pathway0.44
    		Calpain Protease Regulates Cellular Mechanics0.22
    		nNOS Signaling in Skeletal Muscle0.37
    2PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		Fc-EpsilonRI Pathway0.42
    		TCR Signaling0.68
    		PDGF Pathway0.35
    		ITK and TCR Signaling0.54
    3Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Cellular Effects of Sildenafil0.46
    		Melatonin Signaling0.72
    4Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    5NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    		IGF1R Signaling0.37
    		Signaling Involved in Cardiac Hypertrophy0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CACNA1D
        Synaptic transmission- ion currents
    Transcription CREB pathway
    Calcium channels

    5/40 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CACNA1D (see all 40)
        Caspase Cascade
    Fc-GammaR Pathway
    Intracellular Calcium Signaling
    PDGF Pathway
    BMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for CACNA1D
        Transcription CREB pathway

    3 BioSystems Pathways for CACNA1D 
        Calcium Regulation in the Cardiac Cell
    Alzheimers Disease
    Arrhythmogenic right ventricular cardiomyopathy

    5/9        Reactome Pathways for CACNA1D (see all 9)
        Developmental Biology
    NCAM1 interactions
    Metabolism
    Regulation of Insulin Secretion
    NCAM signaling for neurite out-growth

    5/6 PharmGKB Pathways for CACNA1D (see all 6)
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Antiarrhythmic Pathway, Pharmacodynamics
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Celecoxib Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    5/13         Kegg Pathways  (Kegg details for CACNA1D) (see all 13):
        MAPK signaling pathway
    Calcium signaling pathway
    Cardiac muscle contraction
    Vascular smooth muscle contraction
    Glutamatergic synapse


    CACNA1D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CACNA1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for CACNA1D (Q016683 ENSP000002881394) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNB4O003053, ENSP000003435634I2D: score=1 STRING: ENSP00000343563
    CALB1P059373, ENSP000002654314I2D: score=1 STRING: ENSP00000265431
    STX1AQ166233, ENSP000002228124I2D: score=2 STRING: ENSP00000222812
    GABBR2O758993I2D: score=1 
    CACNA1CENSP000002663764STRING: ENSP00000266376
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006816calcium ion transport IDA11160515
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS--
    GO:0007411axon guidance TAS--
    GO:0007605sensory perception of sound IMP--


    CACNA1D for ontologies           About GeneDecksing



    Drugs & Compounds
    for CACNA1D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CACNA1D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CACNA1D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FPL 64176Potent activator of Ca2+ channels (L-type)[120934-96-5]
    NimodipineCa2+ channel blocker (L-type)[66085-59-4]
    (S)-(-)-Bay K 8644Ca2+-channel activator (L-type)[98625-26-4]
    (±)-Bay K 8644Ca2+-channel activator (L-type)[71145-03-4]
    IsradipineCa2+ channel blocker (L-type)[75695-93-1]

    2 HMDB Compounds for CACNA1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    VerapamilAkilen (see all 107)52-53-9--

    10/12 DrugBank Compounds for CACNA1D (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NimodipineNimodipino [INN-Spanish] (see all 2)66085-59-4targetinhibitor20335610 17705883 20334460 19844625 20661350 19029287
    Mibefradil-- 116644-53-2targetinhibitor10372226 10665814 16899990
    Cinnarizine-- 298-57-7targetinhibitor3530295 1281221
    Isradipine(+/-)-Isradipine (see all 5)75695-93-1targetinhibitor11285265 19029287
    Nifedipine-- 21829-25-4targetinhibitor11160515 19029287
    AmlodipineAmlodipine Benzenesulfonate (see all 6)88150-42-9targetinhibitor19029287
    FelodipineDl-Felodipine (see all 4)72509-76-3targetinhibitor19029287
    NicardipineNicardipine HCl (see all 3)55985-32-5targetinhibitor11160515
    Nilvadipine-- 75530-68-6targetinhibitor19029287
    NisoldipineNisoldipin (see all 3)63675-72-9targetinhibitor19029287

    2 Novoseek chemical compound relationships for CACNA1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 54.1 24 1664412 (2), 7760845 (2), 8392192 (1), 1316766 (1) (see all 18)
    sodium 7.58 1 15072700 (1)

    Search CenterWatch for drugs/clinical trials and news about CACNA1D / CAC1D 

    Transcripts
    for CACNA1D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CACNA1D gene (3 alternative transcripts): 
    NM_000720.3  NM_001128839.2  NM_001128840.2  

    Unigene Cluster for CACNA1D:

    Calcium channel, voltage-dependent, L type, alpha 1D subunit
    Hs.476358  [show with all ESTs]
    Unigene Representative Sequence: NM_000720
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350061 ENST00000288139(uc003dgu.4 uc003dgv.4 uc003dgy.4 uc003dgw.4 uc011bes.2)
    ENST00000422281 ENST00000481085 ENST00000464429 ENST00000481478(uc003dgx.1)
    ENST00000498251 ENST00000540742 ENST00000544977

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CACNA1D
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CACNA1D
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate CACNA1D (see all 48):
    hsa-miR-607 hsa-miR-3146 hsa-let-7d hsa-miR-938 hsa-let-7a-2* hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CACNA1D 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNA1D (see all 7)
    OriGene shRNA RFP: CACNA1D
    OriGene siRNA: CACNA1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNA1D
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CACNA1D (NM_001128839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CACNA1D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1D 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNA1D
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNA1D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNA1D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNA1D

    Additional cDNA sequence: 

    AB209171.1 AK294397.1 AK294585.1 EU363339.1 M76558.1 M83566.1 

    4 DOTS entries:

    DT.92419568  DT.112598  DT.40313005  DT.70100900 

    24/125 AceView cDNA sequences (see all 125):

    AA885585 AA861160 NM_000720 AA701888 BE672659 AA703120 CA389011 BI758971 
    M83566 C21063 AI361691 BQ016847 R46658 AI914244 BE550599 BV197217 
    N85902 BU182632 N46744 AI248998 BQ549084 AA978315 BQ549571 AI051972 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47
    SP1:                                                                                                                                          
    SP2:                                                                                                  -                                       
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for CACNA1D

    Expression
    for CACNA1D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CACNA1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTCCTAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CACNA1D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CACNA1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CACNA1D

    SOURCE GeneReport for Unigene cluster: Hs.476358

    UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668
    Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex,
    hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No
    expression in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including CACNA1D: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNA1D
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CACNA1D
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNA1D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNA1D
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1D

    Orthologs
    for CACNA1D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CACNA1D gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CACNA1D1 calcium channel, voltage-dependent, L type, alpha 1D more 80.67(n)
    88.51(a)    		   395895  NM_205034.1  NP_990365.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CACNA1D6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(160198924-160388755)
    zebrafish
    (Danio rerio)    		 Actinopterygii cacna1da1 calcium channel, voltage-dependent, L type, alpha 1D more 73.36(n)
    80.37(a)    		   403310  NM_203484.1  NP_982351.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ca-alpha1D1 , 3 epithelial fluid transport voltage-gated
    calcium more3
    Ca[2+]-channel protein alpha[[1]] subunit D1    		 63(a)3
    62.84(n)1
    66.52(a)1    		   349501  NM_080365.21  NP_525104.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea egl-191 , 3 Expression: neurons, preanal ganglion, ring
    neurons, more3
    Protein EGL-191    		 66(a)
    (best of 3)3
    61.15(n)1
    65.39(a)1    		   IV(7405770-7418097)3
    1775131  NM_001027908.21  NP_001023079.11 


    ENSEMBL Gene Tree for CACNA1D (if available)
    TreeFam Gene Tree for CACNA1D (if available) 

    Paralogs
    for CACNA1D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CACNA1D gene
    CACNA1A2  SCN5A2  SCN9A2  CACNA1I2  SCN7A2  CACNA1F2  SCN8A2  CACNA1G2  
    SCN10A2  SCN3A2  CACNA1E2  SCN2A2  CACNA1S2  CACNA1C2  CACNA1H2  SCN11A2  
    SCN4A2  SCN1A2  CACNA1B2  
    12 SIMAP similar genes for CACNA1D using alignment to 7 protein entries:     CAC1D_HUMAN (see all proteins):
    CACNA1S    CACNA1H    CACNA1F    CACNA1C    CACNA1B    SCN1A
    SCN5A    SCN3A    CACNA1A    CACNA1E    SCN4A    SCN9A

    CACNA1D for paralogs           About GeneDecksing



    Genomic Variants
    for CACNA1D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CAC1D_HUMAN, Q01668
    Polymorphism: A change from seven to eight ATG trinucleotide repeats, resulting in an additional N-terminal methionine,
    has been found in a patient with non-insulin-dependent diabetes mellitus (NIDDM)


    10/5590 NCBI SNPs in CACNA1D are shown (see all 5590)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs756291231,2
    		--53527071(+) GAATTT/CTGTAG 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1868498651,2
    		--53527167(+) GGCTAA/GTTTCT 3 -- us2k10--------
    rs3124841,2
    		C,F,A,--53527289(-) GAGACT/CGGAGA 3 -- us2k110Minor allele frequency- C:0.31MN NA WA CSA EA 554
    rs37558151,2
    		C,F,--53527293(+) CAGTCT/GCCAAA 3 -- us2k15Minor allele frequency- G:0.31NA EA 246
    rs1447958651,2
    		--53527393(+) CTGGTC/TCCCAG 3 -- us2k10--------
    rs1386299571,2
    		--53527395(+) GGTCCC/GCAGTC 3 -- us2k10--------
    rs37558161,2
    		C,F,--53527439(+) GACTAG/CTGTGT 3 -- us2k1 tfbs31Minor allele frequency- C:0.14EA 120
    rs1501014711,2
    		C,--53528057(+) CCCAA-/CCCCCC 3 -- us2k10--------
    rs1417394081,2
    		--53528175(+) CTACCA/GCCCGC 3 -- us2k10--------
    rs1489396111,2
    		C,--53528230(+) AGAGG-/AGAGGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CACNA1D (53528683 - 53778683 bp, first 250kb of CACNA1D)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CACNA1D: --
    Human Gene Mutation Database (HGMD): CACNA1D

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNA1D
    DNA2.0 Custom Variant and Variant Library Synthesis for CACNA1D

    Disorders / Diseases
    for CACNA1D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CACNA1D for disorders           About GeneDecksing

    OMIM gene information: 114206    OMIM disorders: --

    17 diseases for CACNA1D:    About MalaCards
    lambert-eaton myasthenic syndrome    congenital stationary night blindness    night blindness    atrial fibrillation
    myasthenic syndrome    insulinoma    blindness    diabetes mellitus
    sinusitis    lung carcinoma    cerebritis    neuroblastoma
    retinitis    schizophrenia    carcinoma    pancreatitis
    neuronitis

    1 Novoseek disease relationship for CACNA1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 48.5 2 8529524 (1), 7760845 (1)

    Genetic Association Database (GAD): CACNA1D
    Human Genome Epidemiology (HuGE) Navigator: CACNA1D (5 documents)

    Export disorders for CACNA1D gene to outside databases

    Publications
    for CACNA1D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CACNA1D gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with CACNA1D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. (PubMed id 7557998)1, 2, 9 Yamada Y.... Seino Y. (1995)
    2. A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3. (PubMed id 1664412)1, 3, 9 Chin H.M....McBride O.W. (1991)
    3. alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. (PubMed id 11285265)1, 7 Koschak A....Striessnig J. (2001)
    4. Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. (PubMed id 11160515)1, 7 Bell D.C....Dolphin A.C. (2001)
    5. Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients. (PubMed id 11424233)1, 4 Yamada Y....Seino Y. (2001)
    6. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. (PubMed id 1309651)1, 2 Williams M.E.... Harpold M.M. (1992)
    7. Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells. (PubMed id 1309948)1, 2 Seino S....Bell G.I. (1992)
    8. Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers. (PubMed id 19225208)1, 9 Kamide K....Kawano Y. (2009)
    9. Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels. (PubMed id 21998310)1 Bock G....Koschak A. (2011)
    10. Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels. (PubMed id 21998309)1 Tan B.Z....Soong T.W. (2011)

    External Searches for CACNA1D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CACNA1D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 776 HGNC: 1391 AceView: CACNA1D Ensembl:ENSG00000157388 euGenes: HUgn776
    ECgene: CACNA1D Kegg: 776 H-InvDB: CACNA1D

    Other Databases showing CACNA1D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CACNA1D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CACNA1D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CACNA1D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CACNA1D gene:
    Search GeneIP for patents involving CACNA1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CACNA1D gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CACNA1D
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CACNA1D  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CACNA1D   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CACNA1D  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CACNA1D   OriGene 3'-UTR Clone for CACNA1D  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CACNA1D  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CACNA1D   OriGene Custom Protein Services for CACNA1D  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CACNA1D
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CACNA1D
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CACNA1D
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CACNA1D
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CACNA1D
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CACNA1D
     GenScript Custom Purified and Recombinant Proteins Services for CACNA1D GenScript cDNA clones with any tag delivered in your preferred vector for CACNA1D
     GenScript Custom Assay Services for CACNA1D GenScript Custom Superior Antibodies Services for CACNA1D
     GenScript Custom overexpressing Cell Line Services for CACNA1D CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CACNA1D promoter
     Search Chromatin IP Primers for CACNA1D
     RT2 qPCR Primer Assay in human, mouse, rat CACNA1D
     Search GNC Networks for CACNA1D
     SABiosciences PCR Arrays including human, mouse, rat CACNA1D
     Tocris compounds for CACNA1D
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CACNA1D antibodies
     Search for Antibodies for CACNA1D at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CACNA1D
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CACNA1D
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CACNA1D
     SwitchGear 3'UTR luciferase reporter plasmids for CACNA1D
     SwitchGear Promoter luciferase reporter plasmids for CACNA1D
     Search ThermoFisher Antibodies for CACNA1D
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CACNA1D
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CACNA1D gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4