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Aliases for CACNA1B Gene

Aliases for CACNA1B Gene

  • Calcium Voltage-Gated Channel Subunit Alpha1 B 2 3
  • Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit 2 3 5
  • Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 3 4
  • Brain Calcium Channel III 3 4
  • CACNL1A5 3 4
  • BIII 3 4
  • Calcium Channel, Voltage-Dependent, L Type, Alpha 1B Subunit 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide Isoform 5 4
  • Voltage-Gated Calcium Channel Alpha Subunit Cav2.2 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide 3
  • Cav2.2 Voltage-Gated Ca2+ Channel 3
  • Calcium Channel Alpha12.2 Subunit 3
  • Cav2.2 3
  • DYT23 3
  • CACNN 3
  • CACH5 4

External Ids for CACNA1B Gene

Previous HGNC Symbols for CACNA1B Gene

  • CACNL1A5

Previous GeneCards Identifiers for CACNA1B Gene

  • GC09M132202
  • GC09P132561
  • GC09P134074
  • GC09P135990
  • GC09P138048
  • GC09P139892
  • GC09P140772
  • GC09P110240

Summaries for CACNA1B Gene

Entrez Gene Summary for CACNA1B Gene

  • The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CACNA1B Gene

CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) is a Protein Coding gene. Diseases associated with CACNA1B include dystonia 23 and morvan's fibrillary chorea. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. GO annotations related to this gene include calcium ion binding and ion channel activity. An important paralog of this gene is CACNA1A.

UniProtKB/Swiss-Prot for CACNA1B Gene

  • Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Tocris Summary for CACNA1B Gene

  • Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

Gene Wiki entry for CACNA1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA1B Gene

Genomics for CACNA1B Gene

Regulatory Elements for CACNA1B Gene

Genomic Location for CACNA1B Gene

Chromosome:
9
Start:
137,877,789 bp from pter
End:
138,124,624 bp from pter
Size:
246,836 bases
Orientation:
Plus strand

Genomic View for CACNA1B Gene

Genes around CACNA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACNA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACNA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA1B Gene

Proteins for CACNA1B Gene

  • Protein details for CACNA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00975-CAC1B_HUMAN
    Recommended name:
    Voltage-dependent N-type calcium channel subunit alpha-1B
    Protein Accession:
    Q00975
    Secondary Accessions:
    • B1AQK5

    Protein attributes for CACNA1B Gene

    Size:
    2339 amino acids
    Molecular mass:
    262496 Da
    Quaternary structure:
    • Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CACNA1B Gene

    Alternative splice isoforms for CACNA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNA1B Gene

Proteomics data for CACNA1B Gene at MOPED

Post-translational modifications for CACNA1B Gene

  • Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
  • Glycosylation at Asn 256, Asn 1563, and Asn 1675
  • Modification sites at PhosphoSitePlus

Other Protein References for CACNA1B Gene

No data available for DME Specific Peptides for CACNA1B Gene

Domains & Families for CACNA1B Gene

Graphical View of Domain Structure for InterPro Entry

Q00975

UniProtKB/Swiss-Prot:

CAC1B_HUMAN :
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
genes like me logo Genes that share domains with CACNA1B: view

Function for CACNA1B Gene

Molecular function for CACNA1B Gene

GENATLAS Biochemistry:
omega conotoxin sensitive,calcium channel,N type,alpha 1B subunit,exclusively expressed in neuronal tissue
UniProtKB/Swiss-Prot Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Gene Ontology (GO) - Molecular Function for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CACNA1B: view
genes like me logo Genes that share phenotypes with CACNA1B: view

Human Phenotype Ontology for CACNA1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CACNA1B Gene

MGI Knock Outs for CACNA1B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CACNA1B Gene

Localization for CACNA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNA1B Gene COMPARTMENTS Subcellular localization image for CACNA1B gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CACNA1B: view

Pathways & Interactions for CACNA1B Gene

genes like me logo Genes that share pathways with CACNA1B: view

SIGNOR curated interactions for CACNA1B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051924 regulation of calcium ion transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CACNA1B: view

Drugs & Compounds for CACNA1B Gene

(77) Drugs for CACNA1B Gene - From: Novoseek, DGIdb, IUPHAR, DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlodipine Approved Pharma blocker, Target, inhibitor Calcium channel blocker 449
Gabapentin Approved, Investigational Pharma antagonist, Target, inhibitor GABA enhancer 269
Levetiracetam Approved, Investigational Pharma blocker, Target, inhibitor Antiepileptic; binds SV2A 0
Nitrendipine Approved Pharma Inhibition, Pore Blocker Calcium channel blocker 5
Verapamil Approved Pharma Channel blocker, Target, inhibitor 117

(23) Additional Compounds for CACNA1B Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
omega-conotoxin GVIA
Channel blocker
omega-conotoxin MVIIA
Antagonist, Pore Blocker
omega-conotoxin MVIIC
Channel blocker
O-Desmethylverapamil (D-702)
(+-)-Bay K 8644
71145-03-4

(5) Tocris Compounds for CACNA1B Gene

Compound Action Cas Number
(+-)-Bay K 8644 Ca2+ channel activator (L-type) 71145-03-4
(S)-(-)-Bay K 8644 Ca2+-channel activator (L-type) 98625-26-4
Flunarizine dihydrochloride Dual Na+/Ca2+ channel (T-type) blocker 30484-77-6
FPL 64176 Potent activator of Ca2+ channels (L-type) 120934-96-5
Nefiracetam Cognitive enhancer 77191-36-7

(30) ApexBio Compounds for CACNA1B Gene

Compound Action Cas Number
2-APB 524-95-8
Amlodipine Calcium channel blocker 88150-42-9
Amlodipine Besylate Block of L-type calcium channel 111470-99-6
Azelnidipine L-type calcium channel blocker;antihypertensive 123524-52-7
Benidipine HCl Calcium channel blocker 91599-74-5
Cilnidipine Blocker of Dual L- and N-type calcium channel 132203-70-4
Cinepazide maleate 26328-04-1
Clevidipine Butyrate 167221-71-8
Dehydroepiandrosterone (DHEA) Endogenous steroid hormone 53-43-0
Diltiazem HCl 33286-22-5
Felodipine 72509-76-3
Flunarizine 2HCl Calcium entry blocker 30484-77-6
Gabapentin HCl GABA analog 60142-95-2
Isradipine (Dynacirc) Calcium channel blocker 75695-93-1
Lacidipine L-type calcium channel blocker 103890-78-4
Lomerizine HCl 101477-54-7
Manidipine Calcium channel blocker 89226-50-6
Manidipine 2HCl 89226-75-5
Nicardipine HCl 54527-84-3
Nilvadipine 75530-68-6
Nisoldipine 63675-72-9
Nitrendipine Calcium channel blocker 39562-70-4
Osthole Antitumor reagent 484-12-8
Ranolazine 2HCl Partial fatty acid oxidation inhibitor 95635-56-6
Strontium Ranelate 135459-87-9
Tetracaine HCl Anaesthetic and allosteric inhibitor 136-47-0
Tetrandrine 518-34-3
Thioridazine HCl Calcium channel protein inhibitor 130-61-0
Verapamil HCl 152-11-4
Zonisamide Antiepileptic with anticonvulsant and mechanistic effect 68291-97-4
genes like me logo Genes that share compounds with CACNA1B: view

Drug Products

Transcripts for CACNA1B Gene

Unigene Clusters for CACNA1B Gene

Calcium channel, voltage-dependent, N type, alpha 1B subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1B Gene

No ASD Table

Relevant External Links for CACNA1B Gene

GeneLoc Exon Structure for
CACNA1B
ECgene alternative splicing isoforms for
CACNA1B

Expression for CACNA1B Gene

mRNA expression in normal human tissues for CACNA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNA1B Gene

This gene is overexpressed in Brain - Cerebellum (x6.9), Brain - Cerebellar Hemisphere (x6.4), Brain - Cortex (x5.4), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for CACNA1B Gene

This gene is overexpressed in Heart (25.5), Breast (20.6), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CACNA1B Gene



SOURCE GeneReport for Unigene cluster for CACNA1B Gene Hs.495522

mRNA Expression by UniProt/SwissProt for CACNA1B Gene

Q00975-CAC1B_HUMAN
Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
genes like me logo Genes that share expression patterns with CACNA1B: view

Protein tissue co-expression partners for CACNA1B Gene

Primer Products

In Situ Assay Products

Orthologs for CACNA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNA1B 35
  • 89.65 (n)
  • 93.54 (a)
CACNA1B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNA1B 35
  • 90.21 (n)
  • 94.3 (a)
CACNA1B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacna1b 35
  • 86.88 (n)
  • 92.96 (a)
Cacna1b 16
Cacna1b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNA1B 35
  • 99.17 (n)
  • 99.26 (a)
CACNA1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacna1b 35
  • 86.72 (n)
  • 92.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNA1B 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNA1B 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACNA1B 35
  • 76.35 (n)
  • 82.04 (a)
CACNA1B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNA1B 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cacna1ba 35
  • 69.06 (n)
  • 71.51 (a)
cacna1ba 36
  • 68 (a)
OneToMany
cacna1bb 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11382 35
fruit fly
(Drosophila melanogaster)
Insecta cac 37
  • 62 (a)
cac 35
  • 62.23 (n)
  • 64.3 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002578 35
  • 64.54 (n)
  • 65.9 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-2 35
  • 58.81 (n)
  • 60.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for CACNA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CACNA1B Gene

ENSEMBL:
Gene Tree for CACNA1B (if available)
TreeFam:
Gene Tree for CACNA1B (if available)

Paralogs for CACNA1B Gene

Paralogs for CACNA1B Gene

genes like me logo Genes that share paralogs with CACNA1B: view

Variants for CACNA1B Gene

Sequence variations from dbSNP and Humsavar for CACNA1B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_048741 -
rs12377346 -, - 138,059,103(+) AGTAC(A/G)AGCTG reference, missense
rs7873074 - 138,023,327(+) CCCCC(G/T)CGGCG reference, missense
rs11137342 - 138,023,729(+) AGGAG(A/G)CCACG reference, missense
VAR_073432 Dystonia 23 (DYT23)

Structural Variations from Database of Genomic Variants (DGV) for CACNA1B Gene

Variant ID Type Subtype PubMed ID
nsv894678 CNV Loss 21882294
nsv509338 CNV Insertion 20534489
esv2137371 CNV Deletion 18987734
dgv48e194 CNV Deletion 18987734
esv4238 CNV Deletion 18987735
nsv415473 CNV Loss 16902084
dgv121e19 CNV Loss 19470904
nsv512132 CNV Loss 21212237
esv2666889 CNV Deletion 23128226
nsv415556 CNV Loss 16902084
nsv819257 CNV Gain 19587683
nsv512133 CNV Loss 21212237
esv26628 CNV Gain 19812545
nsv894680 CNV Gain 21882294
nsv416156 CNV Loss 16902084
nsv415991 CNV Loss 16902084
esv1575931 CNV Insertion 17803354
nsv894681 CNV Loss 21882294
nsv415961 CNV Loss 16902084
esv2433439 CNV Insertion 19546169
esv2562307 CNV Deletion 19546169
esv2219909 CNV Deletion 18987734
nsv466691 CNV Gain 19166990
nsv469920 CNV Gain 18288195
nsv894682 CNV Gain 21882294
nsv831764 CNV Loss 17160897
dgv2429e1 CNV Complex 17122850
esv2375692 CNV Deletion 18987734
esv2667721 CNV Deletion 23128226
nsv8587 CNV Gain+Loss 18304495
esv2626823 CNV Deletion 19546169
esv24429 CNV Gain+Loss 19812545
nsv821456 CNV Deletion 20802225
nsv433507 CNV Loss 18776910
esv1367927 CNV Deletion 17803354
nsv894683 CNV Gain 21882294
nsv825201 CNV Gain 20364138
nsv482947 CNV Loss 15286789
nsv6777 CNV Loss 18451855
nsv438117 CNV Loss 16468122
esv29520 CNV Loss 19812545
nsv499630 CNV Loss 21111241
esv2673994 CNV Deletion 23128226
esv27764 CNV Gain+Loss 19812545
nsv517336 CNV Gain+Loss 19592680
dgv8464n71 CNV Gain 21882294
nsv894686 CNV Gain 21882294
dgv8465n71 CNV Gain 21882294
dgv2430e1 CNV Complex 17122850
nsv438118 CNV Loss 16468122
nsv466692 CNV Gain 19166990
nsv8588 CNV Gain 18304495
nsv8589 CNV Loss 18304495

Variation tolerance for CACNA1B Gene

Residual Variation Intolerance Score: 0.789% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.27; 98.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CACNA1B Gene

HapMap Linkage Disequilibrium report
CACNA1B
Human Gene Mutation Database (HGMD)
CACNA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA1B Gene

Disorders for CACNA1B Gene

MalaCards: The human disease database

(7) MalaCards diseases for CACNA1B Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dystonia 23
  • dyt23
morvan's fibrillary chorea
multifocal dystonia
chronic pain
  • pain - chronic
autoimmune autonomic ganglionopathy
  • autoimmune autonomic neuropathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CAC1B_HUMAN
  • Dystonia 23 (DYT23) [MIM:614860]: A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT23 is an autosomal dominant dystonia affecting the face, neck, limbs. Some DYT23 patients manifest generalized myoclonus in addition to progressive action-induced multifocal dystonia. {ECO:0000269 PubMed:25296916}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CACNA1B

Genetic Association Database (GAD)
CACNA1B
Human Genome Epidemiology (HuGE) Navigator
CACNA1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACNA1B
genes like me logo Genes that share disorders with CACNA1B: view

No data available for Genatlas for CACNA1B Gene

Publications for CACNA1B Gene

  1. Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. (PMID: 1321501) Williams M.E. … Harpold M.M. (Science 1992) 3 4 23 67
  2. Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. (PMID: 19634509) Ogihara T. … Kakinuma C. (Arzneimittelforschung 2009) 23 25
  3. Verapamil for cluster headache. Clinical pharmacology and possible mode of action. (PMID: 19125880) Tfelt-Hansen P. … Tfelt-Hansen J. (Headache 2009) 25 26
  4. Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. (PMID: 17461889) De Smedt T. … Boon P. (CNS Drug Rev 2007) 25 26
  5. Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels. (PMID: 16857708) Castiglioni A.J. … Lipscombe D. (J. Physiol. (Lond.) 2006) 3 23

Products for CACNA1B Gene

Sources for CACNA1B Gene

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