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Aliases for CACNA1B Gene

Aliases for CACNA1B Gene

  • Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit 2 3
  • CACNL1A5 3 4 6
  • Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 3 4
  • Brain Calcium Channel III 3 4
  • BIII 3 4
  • Calcium Channel, Voltage-Dependent, L Type, Alpha 1B Subunit 3
  • Calcium Channel, Voltage-Dependent, Alpha 1B Subunit, N Type 3
  • Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1B 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide Isoform 5 4
  • Voltage-Gated Calcium Channel Alpha Subunit Cav2.2 3
  • Calcium Channel, L Type, Alpha-1 Polypeptide 3
  • Cav2.2 Voltage-Gated Ca2+ Channel 3
  • Calcium Channel Alpha12.2 Subunit 3
  • Calcium Channel, N Type 3
  • Cav2.2 3
  • CACNN 3
  • DYT23 3
  • CACH5 4

External Ids for CACNA1B Gene

Previous HGNC Symbols for CACNA1B Gene

  • CACNL1A5

Previous GeneCards Identifiers for CACNA1B Gene

  • GC09M132202
  • GC09P132561
  • GC09P134074
  • GC09P135990
  • GC09P138048
  • GC09P139892
  • GC09P140772
  • GC09P110240

Summaries for CACNA1B Gene

Entrez Gene Summary for CACNA1B Gene

  • The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CACNA1B Gene

CACNA1B (Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit) is a Protein Coding gene. Diseases associated with CACNA1B include epidemic pleurodynia and autoimmune autonomic ganglionopathy. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is CACNA1A.

UniProtKB/Swiss-Prot for CACNA1B Gene

  • Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons

Tocris Summary for CACNA1B Gene

  • Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Gene Wiki entry for CACNA1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA1B Gene

Genomics for CACNA1B Gene

Regulatory Elements for CACNA1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CACNA1B Gene

Start:
137,877,789 bp from pter
End:
138,124,624 bp from pter
Size:
246,836 bases
Orientation:
Plus strand

Genomic View for CACNA1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACNA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA1B Gene

Proteins for CACNA1B Gene

  • Protein details for CACNA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00975-CAC1B_HUMAN
    Recommended name:
    Voltage-dependent N-type calcium channel subunit alpha-1B
    Protein Accession:
    Q00975
    Secondary Accessions:
    • B1AQK5

    Protein attributes for CACNA1B Gene

    Size:
    2339 amino acids
    Molecular mass:
    262496 Da
    Quaternary structure:
    • Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CACNA1B Gene

    Alternative splice isoforms for CACNA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNA1B Gene

Proteomics data for CACNA1B Gene at MOPED

Post-translational modifications for CACNA1B Gene

  • Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
  • Ubiquitination at Lys732
  • Glycosylation at Asn256, Asn1563, and Asn1675
  • Modification sites at PhosphoSitePlus

Other Protein References for CACNA1B Gene

No data available for DME Specific Peptides for CACNA1B Gene

Domains for CACNA1B Gene

Gene Families for CACNA1B Gene

HGNC:
  • CACN :Calcium channel subunits
  • EFHAND :EF-hand domain containing
  • CACN1 :Voltage-gated ion channels / Calcium channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q00975

UniProtKB/Swiss-Prot:

CAC1B_HUMAN :
  • Q00975
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
genes like me logo Genes that share domains with CACNA1B: view

Function for CACNA1B Gene

Molecular function for CACNA1B Gene

GENATLAS Biochemistry:
omega conotoxin sensitive,calcium channel,N type,alpha 1B subunit,exclusively expressed in neuronal tissue
UniProtKB/Swiss-Prot Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons

Gene Ontology (GO) - Molecular Function for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005245 voltage-gated calcium channel activity TAS 1321501
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 11438518
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CACNA1B: view
genes like me logo Genes that share phenotypes with CACNA1B: view

Animal Models for CACNA1B Gene

MGI Knock Outs for CACNA1B:

miRNA for CACNA1B Gene

miRTarBase miRNAs that target CACNA1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNA1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CACNA1B Gene

Localization for CACNA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACNA1B Gene COMPARTMENTS Subcellular localization image for CACNA1B gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005891 voltage-gated calcium channel complex IEA --
GO:0016020 membrane --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CACNA1B: view

Pathways for CACNA1B Gene

genes like me logo Genes that share pathways with CACNA1B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CACNA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 1321501
GO:0006811 ion transport --
GO:0006816 calcium ion transport --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with CACNA1B: view

Compounds for CACNA1B Gene

Compound Products

(5) Tocris Compounds for CACNA1B Gene

Compound Action Cas Number
Isradipine Ca2+ channel blocker (L-type) [75695-93-1]
Mibefradil dihydrochloride Ca2+ channel blocker (T-type) [116666-63-8]
omega-Conotoxin GVIA Ca2+ channel blocker (N-type) [106375-28-4]
Pregabalin Anticonvulsant; selectively binds the alpha2delta subunit of voltage-sensitive calcium channels [148553-50-8]
SNX 482 Potent and selective CaV2.3 blocker (R-type) [203460-30-4]

(30) ApexBio Compounds for CACNA1B Gene

Compound Action Cas Number
2-APB [524-95-8]
Amlodipine Calcium channel blocker [88150-42-9]
Amlodipine Besylate Block of L-type calcium channel [111470-99-6]
Azelnidipine L-type calcium channel blocker;antihypertensive [123524-52-7]
Benidipine HCl Calcium channel blocker [91599-74-5]
Cilnidipine Blocker of Dual L- and N-type calcium channel [132203-70-4]
Cinepazide maleate [26328-04-1]
Clevidipine Butyrate [167221-71-8]
Dehydroepiandrosterone (DHEA) Endogenous steroid hormone [53-43-0]
Diltiazem HCl [33286-22-5]
Felodipine [72509-76-3]
Flunarizine 2HCl Calcium entry blocker [30484-77-6]
Gabapentin HCl GABA analog [60142-95-2]
Isradipine (Dynacirc) Calcium channel blocker [75695-93-1]
Lacidipine L-type calcium channel blocker [103890-78-4]
Lomerizine HCl [101477-54-7]
Manidipine Calcium channel blocker [89226-50-6]
Manidipine 2HCl [89226-75-5]
Nicardipine HCl [54527-84-3]
Nilvadipine [75530-68-6]
Nisoldipine [63675-72-9]
Nitrendipine Calcium channel blocker [39562-70-4]
Osthole Antitumor reagent [484-12-8]
Ranolazine 2HCl Partial fatty acid oxidation inhibitor [95635-56-6]
Strontium Ranelate [135459-87-9]
Tetracaine HCl Anaesthetic and allosteric inhibitor [136-47-0]
Tetrandrine [518-34-3]
Thioridazine HCl Calcium channel protein inhibitor [130-61-0]
Verapamil HCl [152-11-4]
Zonisamide Antiepileptic with anticonvulsant and mechanistic effect [68291-97-4]

(3) HMDB Compounds for CACNA1B Gene

Compound Synonyms Cas Number PubMed IDs
Amlodipine
  • AMVAZ
88150-42-9
Calcium
  • Ca
7440-70-2
Gabapentin
  • 1-(Aminomethyl)cyclohexaneacetic acid
60142-96-3

(5) Drugbank Compounds for CACNA1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Agmatine
306-60-5 target antagonist
Amlodipine
  • Amlodipine Benzenesulfonate
88150-42-9 target inhibitor
Gabapentin
  • Gabapentin GR
60142-96-3 target inhibitor
Levetiracetam
  • Levetiracetam [INN]
102767-28-2 target inhibitor
Verapamil
  • Verapamil [Usan:Ban:Inn]
52-53-9 target inhibitor

(4) IUPHAR Ligand for CACNA1B Gene

Ligand Type Action Affinity Pubmed IDs
omega-conotoxin MVIIA Pore Blocker Antagonist 1
Pb2+ Activator None
omega-conotoxin GVIA Channel blocker None
omega-conotoxin MVIIC Channel blocker None

(53) Novoseek inferred chemical compound relationships for CACNA1B Gene

Compound -log(P) Hits PubMed IDs
cilnidipine 94 25
ziconotide 93.3 20
calcium 81.7 233
omega conotoxin mviic 70 5
amlodipine 63.1 4
genes like me logo Genes that share compounds with CACNA1B: view

Transcripts for CACNA1B Gene

Unigene Clusters for CACNA1B Gene

Calcium channel, voltage-dependent, N type, alpha 1B subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CACNA1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA1B Gene

No ASD Table

Relevant External Links for CACNA1B Gene

GeneLoc Exon Structure for
CACNA1B
ECgene alternative splicing isoforms for
CACNA1B

Expression for CACNA1B Gene

mRNA expression in normal human tissues for CACNA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNA1B Gene

This gene is overexpressed in Brain - Cerebellum (6.9), Brain - Cerebellar Hemisphere (6.4), Brain - Cortex (5.4), Brain - Frontal Cortex (BA9) (4.6), and Brain - Anterior cingulate cortex (BA24) (4.0).

Protein differential expression in normal tissues for CACNA1B Gene

This gene is overexpressed in Heart (25.5), Breast (20.6), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACNA1B Gene

SOURCE GeneReport for Unigene cluster for CACNA1B Gene Hs.495522

mRNA Expression by UniProt/SwissProt for CACNA1B Gene

Q00975-CAC1B_HUMAN
Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta
genes like me logo Genes that share expressions with CACNA1B: view

Expression partners for CACNA1B Gene

In Situ Assay Products

Orthologs for CACNA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACNA1B 35
  • 89.65 (n)
  • 93.54 (a)
CACNA1B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNA1B 35
  • 90.21 (n)
  • 94.3 (a)
CACNA1B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacna1b 35
  • 86.88 (n)
  • 92.96 (a)
Cacna1b 16
Cacna1b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACNA1B 35
  • 99.17 (n)
  • 99.26 (a)
CACNA1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacna1b 35
  • 86.72 (n)
  • 92.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CACNA1B 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNA1B 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACNA1B 35
  • 76.35 (n)
  • 82.04 (a)
CACNA1B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNA1B 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cacna1ba 35
  • 69.06 (n)
  • 71.51 (a)
cacna1ba 36
  • 68 (a)
OneToMany
cacna1bb 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11382 35
fruit fly
(Drosophila melanogaster)
Insecta cac 37
  • 62 (a)
cac 35
  • 62.23 (n)
  • 64.3 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002578 35
  • 64.54 (n)
  • 65.9 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-2 35
  • 58.81 (n)
  • 60.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for CACNA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CACNA1B Gene

ENSEMBL:
Gene Tree for CACNA1B (if available)
TreeFam:
Gene Tree for CACNA1B (if available)

Paralogs for CACNA1B Gene

Paralogs for CACNA1B Gene

genes like me logo Genes that share paralogs with CACNA1B: view

Variants for CACNA1B Gene

Sequence variations from dbSNP and Humsavar for CACNA1B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs766373 -- 138,111,320(+) GTAAA(A/G)GGAAA intron-variant
rs766374 -- 138,111,562(+) CGGTG(C/G)TGCTA intron-variant
rs766375 -- 138,111,368(+) ACATG(C/T)ACCAC intron-variant
rs936248 -- 138,021,915(-) AGGCC(C/T)GCCCT intron-variant
rs936249 -- 138,076,863(+) TTTGC(C/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACNA1B Gene

Variant ID Type Subtype PubMed ID
nsv894678 CNV Loss 21882294
nsv509338 CNV Insertion 20534489
esv2137371 CNV Deletion 18987734
dgv48e194 CNV Deletion 18987734
esv4238 CNV Deletion 18987735
nsv415473 CNV Loss 16902084
dgv121e19 CNV Loss 19470904
nsv512132 CNV Loss 21212237
esv2666889 CNV Deletion 23128226
nsv415556 CNV Loss 16902084
nsv819257 CNV Gain 19587683
nsv512133 CNV Loss 21212237
esv26628 CNV Gain 19812545
nsv894680 CNV Gain 21882294
nsv416156 CNV Loss 16902084
nsv415991 CNV Loss 16902084
esv1575931 CNV Insertion 17803354
nsv894681 CNV Loss 21882294
nsv415961 CNV Loss 16902084
esv2433439 CNV Insertion 19546169
esv2562307 CNV Deletion 19546169
esv2219909 CNV Deletion 18987734
nsv466691 CNV Gain 19166990
nsv469920 CNV Gain 18288195
nsv894682 CNV Gain 21882294
nsv831764 CNV Loss 17160897
dgv2429e1 CNV Complex 17122850
esv2375692 CNV Deletion 18987734
esv2667721 CNV Deletion 23128226
nsv8587 CNV Gain+Loss 18304495
esv2626823 CNV Deletion 19546169
esv24429 CNV Gain+Loss 19812545
nsv821456 CNV Deletion 20802225
nsv433507 CNV Loss 18776910
esv1367927 CNV Deletion 17803354
nsv894683 CNV Gain 21882294
nsv825201 CNV Gain 20364138
nsv482947 CNV Loss 15286789
nsv6777 CNV Loss 18451855
nsv438117 CNV Loss 16468122
esv29520 CNV Loss 19812545
nsv499630 CNV Loss 21111241
esv2673994 CNV Deletion 23128226
esv27764 CNV Gain+Loss 19812545
nsv517336 CNV Gain+Loss 19592680
dgv8464n71 CNV Gain 21882294
nsv894686 CNV Gain 21882294
dgv8465n71 CNV Gain 21882294
dgv2430e1 CNV Complex 17122850
nsv438118 CNV Loss 16468122
nsv466692 CNV Gain 19166990
nsv8588 CNV Gain 18304495
nsv8589 CNV Loss 18304495

Relevant External Links for CACNA1B Gene

HapMap Linkage Disequilibrium report
CACNA1B
Human Gene Mutation Database (HGMD)
CACNA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA1B Gene

Disorders for CACNA1B Gene

(1) University of Copenhagen DISEASES for CACNA1B Gene

(12) Novoseek inferred disease relationships for CACNA1B Gene

Disease -log(P) Hits PubMed IDs
lambert-eaton myasthenic syndrome 47.5 1
essential hypertension 26 1
pheochromocytoma 20.4 1
hyperalgesia 18.8 1
small cell lung cancer 4.71 1

Relevant External Links for CACNA1B

Genetic Association Database (GAD)
CACNA1B
Human Genome Epidemiology (HuGE) Navigator
CACNA1B
genes like me logo Genes that share disorders with CACNA1B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CACNA1B Gene

Publications for CACNA1B Gene

  1. Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. (PMID: 1321501) Williams M.E. … Harpold M.M. (Science 1992) 3 4 23
  2. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. (PMID: 11130074) Schiff M.L. … DiversAc-Pierluissi M. (Nature 2000) 3 23
  3. Mechanosensitivity of N-type calcium channel currents. (PMID: 12414690) Calabrese B. … Morris C.E. (Biophys. J. 2002) 3 23
  4. Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit. (PMID: 14602720) Stotz S.C. … Zamponi G.W. (J. Biol. Chem. 2004) 3 23
  5. Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels. (PMID: 16857708) Castiglioni A.J. … Lipscombe D. (J. Physiol. (Lond.) 2006) 3 23

Products for CACNA1B Gene

Sources for CACNA1B Gene

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