Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CACHD1 Gene

Aliases for CACHD1 Gene

  • Cache Domain Containing 1 2 3
  • Von Willebrand Factor Type A And Cache Domain Containing 1 2
  • Cache Domain-Containing Protein 1 4
  • KIAA1573 4
  • VWCD1 4

External Ids for CACHD1 Gene

Previous Symbols for CACHD1 Gene

  • VWCD1

Summaries for CACHD1 Gene

GeneCards Summary for CACHD1 Gene

CACHD1 (Cache Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CACHD1 Gene

  • May regulate voltage-dependent calcium channels.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACHD1 Gene

Genomics for CACHD1 Gene

Genomic Location for CACHD1 Gene

Start:
64,470,792 bp from pter
End:
64,693,058 bp from pter
Size:
222,267 bases
Orientation:
Plus strand

Genomic View for CACHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACHD1 Gene

Regulatory Elements for CACHD1 Gene

Proteins for CACHD1 Gene

  • Protein details for CACHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VU97-CAHD1_HUMAN
    Recommended name:
    VWFA and cache domain-containing protein 1
    Protein Accession:
    Q5VU97
    Secondary Accessions:
    • Q49AE9
    • Q658T4
    • Q7Z3P2
    • Q9H7W4
    • Q9H9W3
    • Q9HCJ9

    Protein attributes for CACHD1 Gene

    Size:
    1274 amino acids
    Molecular mass:
    142290 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14105.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14860.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70309.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CACHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACHD1 Gene

Proteomics data for CACHD1 Gene at MOPED

Post-translational modifications for CACHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn145

Other Protein References for CACHD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACHD1 Gene

Domains for CACHD1 Gene

Protein Domains for CACHD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CACHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VU97

UniProtKB/Swiss-Prot:

CAHD1_HUMAN
Domain:
  • Contains 2 cache domains.:
    • Q5VU97
  • Contains 1 VWFA domain.:
    • Q5VU97
Family:
  • Belongs to the calcium channel subunit alpha-2/delta family.:
    • Q5VU97
genes like me logo Genes that share domains with CACHD1: view

No data available for Gene Families for CACHD1 Gene

Function for CACHD1 Gene

Molecular function for CACHD1 Gene

UniProtKB/Swiss-Prot Function: May regulate voltage-dependent calcium channels.

miRNA for CACHD1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CACHD1 Gene

Localization for CACHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACHD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACHD1 Gene COMPARTMENTS Subcellular localization image for CACHD1 gene
Compartment Confidence
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CACHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CACHD1: view

Pathways for CACHD1 Gene

SuperPathways for CACHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CACHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
genes like me logo Genes that share ontologies with CACHD1: view

No data available for Pathways by source for CACHD1 Gene

Compounds for CACHD1 Gene

(1) HMDB Compounds for CACHD1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CACHD1: view

Transcripts for CACHD1 Gene

Unigene Clusters for CACHD1 Gene

Cache domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACHD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CACHD1 Gene

GeneLoc Exon Structure for
CACHD1
ECgene alternative splicing isoforms for
CACHD1

Expression for CACHD1 Gene

mRNA expression in normal human tissues for CACHD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CACHD1 Gene

SOURCE GeneReport for Unigene cluster for CACHD1 Gene Hs.443891

genes like me logo Genes that share expressions with CACHD1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CACHD1 Gene

Orthologs for CACHD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACHD1 35
  • 99.67 (n)
  • 99.84 (a)
CACHD1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACHD1 35
  • 92.45 (n)
  • 98.53 (a)
CACHD1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACHD1 35
  • 92.62 (n)
  • 98.76 (a)
CACHD1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cachd1 35
  • 89.62 (n)
  • 97.55 (a)
Cachd1 16
Cachd1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACHD1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cachd1 35
  • 89.92 (n)
  • 97.87 (a)
chicken
(Gallus gallus)
Aves CACHD1 35
  • 82.61 (n)
  • 95.83 (a)
CACHD1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACHD1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10935 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cachd1 35
  • 78.39 (n)
  • 92.72 (a)
Str.2042 35
zebrafish
(Danio rerio)
Actinopterygii cachd1 35
  • 75.99 (n)
  • 88.06 (a)
cachd1 36
  • 83 (a)
OneToOne
Dr.15338 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009043 35
  • 48.7 (n)
  • 39.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16868 35
  • 47.14 (n)
  • 35.17 (a)
CG16868 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
Species with no ortholog for CACHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACHD1 Gene

ENSEMBL:
Gene Tree for CACHD1 (if available)
TreeFam:
Gene Tree for CACHD1 (if available)

Paralogs for CACHD1 Gene

No data available for Paralogs for CACHD1 Gene

Variants for CACHD1 Gene

Sequence variations from dbSNP and Humsavar for CACHD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs90268 -- 64,520,172(+) GCCGG(A/C)CTCAT intron-variant
rs160115 -- 64,520,887(+) GAGAC(A/G)TGCAG intron-variant
rs216286 -- 64,530,868(+) tctgt(C/T)taaaa intron-variant
rs305539 -- 64,483,723(+) tttta(A/G)aaatg intron-variant
rs305540 -- 64,486,071(+) gtgaa(A/G)tggta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CACHD1 Gene

Variant ID Type Subtype PubMed ID
nsv830048 CNV Gain 17160897
esv2660804 CNV Deletion 23128226
esv268167 CNV Insertion 20981092
esv273854 CNV Insertion 20981092
esv1280177 CNV Insertion 17803354
esv1980143 CNV Deletion 18987734
nsv522029 CNV Loss 19592680
esv2667664 CNV Deletion 23128226
nsv508237 CNV Loss 20534489
esv2749152 CNV Deletion 23290073

Relevant External Links for CACHD1 Gene

HapMap Linkage Disequilibrium report
CACHD1
Human Gene Mutation Database (HGMD)
CACHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACHD1 Gene

Disorders for CACHD1 Gene

Relevant External Links for CACHD1

Genetic Association Database (GAD)
CACHD1
Human Genome Epidemiology (HuGE) Navigator
CACHD1
genes like me logo Genes that share disorders with CACHD1: view

No data available for UniProtKB/Swiss-Prot for CACHD1 Gene

Publications for CACHD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for CACHD1 Gene

  • antibodies-online peptides for CACHD1
  • antibodies-online antibodies for CACHD1
  • antibodies-online kits for CACHD1

Sources for CACHD1 Gene

Back to Top

Content