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Aliases for CACFD1 Gene

Aliases for CACFD1 Gene

  • Calcium Channel Flower Domain Containing 1 2 3
  • C9orf7 3 4 6
  • Calcium Channel Flower Domain-Containing Protein 1 3 4
  • FLOWER 3 6
  • Chromosome 9 Open Reading Frame 7 2
  • Calcium Channel Flower Homolog 3
  • D9S2135 3

External Ids for CACFD1 Gene

Previous Symbols for CACFD1 Gene

  • C9orf7

Summaries for CACFD1 Gene

GeneCards Summary for CACFD1 Gene

CACFD1 (Calcium Channel Flower Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACFD1 Gene

Genomics for CACFD1 Gene

Genomic Location for CACFD1 Gene

Start:
133,459,965 bp from pter
End:
133,470,848 bp from pter
Size:
10,884 bases
Orientation:
Plus strand

Genomic View for CACFD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CACFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACFD1 Gene

No data available for Regulatory Elements for CACFD1 Gene

Proteins for CACFD1 Gene

  • Protein details for CACFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGQ2-FLOWR_HUMAN
    Recommended name:
    Calcium channel flower homolog
    Protein Accession:
    Q9UGQ2
    Secondary Accessions:
    • B7Z3T8
    • B7Z5E1
    • F5GXX4
    • Q5SXD4
    • Q8NBM6

    Protein attributes for CACFD1 Gene

    Size:
    172 amino acids
    Molecular mass:
    18470 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CACFD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACFD1 Gene

Proteomics data for CACFD1 Gene at MOPED

Post-translational modifications for CACFD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACFD1 Gene

No data available for DME Specific Peptides for CACFD1 Gene

Domains for CACFD1 Gene

Protein Domains for CACFD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGQ2

UniProtKB/Swiss-Prot:

FLOWR_HUMAN
Family:
  • Belongs to the calcium channel flower family.:
    • Q9UGQ2
genes like me logo Genes that share domains with CACFD1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CACFD1 Gene

Function for CACFD1 Gene

Gene Ontology (GO) - Molecular Function for CACFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005262 calcium channel activity TAS --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CACFD1: view

Phenotypes for CACFD1 Gene

genes like me logo Genes that share phenotypes with CACFD1: view

Animal Models for CACFD1 Gene

MGI Knock Outs for CACFD1:

miRNA for CACFD1 Gene

miRTarBase miRNAs that target CACFD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CACFD1 Gene

Localization for CACFD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACFD1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CACFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane --
GO:0030285 integral component of synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with CACFD1: view

No data available for Subcellular locations from COMPARTMENTS for CACFD1 Gene

Pathways for CACFD1 Gene

SuperPathways for CACFD1 Gene

No Data Available

Interacting Proteins for CACFD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440832%0d%0a9606.ENSP00000233047%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000440832 Q9UGQ2-FLOWR_HUMAN for CACFD1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CACFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0008150 biological_process ND --
GO:0048488 synaptic vesicle endocytosis IEA --
GO:0051899 membrane depolarization TAS --
GO:0070588 calcium ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with CACFD1: view

No data available for Pathways by source for CACFD1 Gene

Transcripts for CACFD1 Gene

Unigene Clusters for CACFD1 Gene

Calcium channel flower domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACFD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -

Relevant External Links for CACFD1 Gene

GeneLoc Exon Structure for
CACFD1
ECgene alternative splicing isoforms for
CACFD1

Expression for CACFD1 Gene

mRNA expression in normal human tissues for CACFD1 Gene

mRNA differential expression in normal tissues according to GTEx for CACFD1 Gene

This gene is overexpressed in Liver (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CACFD1 Gene

SOURCE GeneReport for Unigene cluster for CACFD1 Gene Hs.62003

genes like me logo Genes that share expressions with CACFD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CACFD1 Gene

Orthologs for CACFD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACFD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACFD1 35
  • 99.57 (n)
  • 99.14 (a)
CACFD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CACFD1 35
  • 86.75 (n)
  • 85.9 (a)
MGC139698 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACFD1 35
  • 81.54 (n)
  • 82.64 (a)
CACFD1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacfd1 35
  • 78.71 (n)
  • 81.33 (a)
Cacfd1 16
Cacfd1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACFD1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACFD1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacfd1 35
  • 79.63 (n)
  • 81.48 (a)
chicken
(Gallus gallus)
Aves C17H9ORF7 35
  • 69.64 (n)
  • 68.15 (a)
C17H9ORF7 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACFD1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68663 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cacfd1 35
  • 70.34 (n)
  • 71.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4696 35
zebrafish
(Danio rerio)
Actinopterygii CACFD1 36
  • 55 (a)
OneToOne
si:ch73-209e20.5 35
  • 65.99 (n)
  • 63.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta fwe 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F20D1.1 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3337 36
  • 31 (a)
OneToOne
Species with no ortholog for CACFD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACFD1 Gene

ENSEMBL:
Gene Tree for CACFD1 (if available)
TreeFam:
Gene Tree for CACFD1 (if available)

Paralogs for CACFD1 Gene

No data available for Paralogs for CACFD1 Gene

Variants for CACFD1 Gene

Sequence variations from dbSNP and Humsavar for CACFD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs739467 -- 133,461,432(+) TGTAG(G/T)AGAGA intron-variant
rs739468 -- 133,461,126(+) GCAGG(G/T)TTTAA intron-variant
rs756820 -- 133,461,735(-) ATGCC(A/G)CAAGT intron-variant
rs1054380 -- 133,468,879(+) GCTGT(C/G)TGGAC utr-variant-3-prime
rs1858879 -- 133,460,785(-) GCCCT(C/G)AGCTC intron-variant

Relevant External Links for CACFD1 Gene

HapMap Linkage Disequilibrium report
CACFD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CACFD1 Gene

Disorders for CACFD1 Gene

No disorders were found for CACFD1 Gene.

No data available for UniProtKB/Swiss-Prot for CACFD1 Gene

Publications for CACFD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for CACFD1 Gene

Sources for CACFD1 Gene

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