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Aliases for CACFD1 Gene

Aliases for CACFD1 Gene

  • Calcium Channel Flower Domain Containing 1 2 3 5
  • Calcium Channel Flower Domain-Containing Protein 1 3 4
  • C9orf7 3 4
  • Chromosome 9 Open Reading Frame 7 2
  • D9S2135 3
  • FLOWER 3

External Ids for CACFD1 Gene

Previous HGNC Symbols for CACFD1 Gene

  • C9orf7

Previous GeneCards Identifiers for CACFD1 Gene

  • GC09P136326

Summaries for CACFD1 Gene

GeneCards Summary for CACFD1 Gene

CACFD1 (Calcium Channel Flower Domain Containing 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include calcium channel activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACFD1 Gene

Genomics for CACFD1 Gene

Regulatory Elements for CACFD1 Gene

Enhancers for CACFD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CACFD1 on UCSC Golden Path with GeneCards custom track

Promoters for CACFD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CACFD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CACFD1 Gene

Chromosome:
9
Start:
133,459,965 bp from pter
End:
133,470,848 bp from pter
Size:
10,884 bases
Orientation:
Plus strand

Genomic View for CACFD1 Gene

Genes around CACFD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACFD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACFD1 Gene

Proteins for CACFD1 Gene

  • Protein details for CACFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGQ2-FLOWR_HUMAN
    Recommended name:
    Calcium channel flower homolog
    Protein Accession:
    Q9UGQ2
    Secondary Accessions:
    • B7Z3T8
    • B7Z5E1
    • F5GXX4
    • Q5SXD4
    • Q8NBM6

    Protein attributes for CACFD1 Gene

    Size:
    172 amino acids
    Molecular mass:
    18470 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CACFD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACFD1 Gene

Proteomics data for CACFD1 Gene at MOPED

Post-translational modifications for CACFD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACFD1 Gene

No data available for DME Specific Peptides for CACFD1 Gene

Domains & Families for CACFD1 Gene

Protein Domains for CACFD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CACFD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGQ2

UniProtKB/Swiss-Prot:

FLOWR_HUMAN :
  • Belongs to the calcium channel flower family.
Family:
  • Belongs to the calcium channel flower family.
genes like me logo Genes that share domains with CACFD1: view

No data available for Gene Families for CACFD1 Gene

Function for CACFD1 Gene

Gene Ontology (GO) - Molecular Function for CACFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CACFD1: view
genes like me logo Genes that share phenotypes with CACFD1: view

Animal Models for CACFD1 Gene

MGI Knock Outs for CACFD1:

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CACFD1 Gene

Localization for CACFD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACFD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CACFD1 Gene COMPARTMENTS Subcellular localization image for CACFD1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CACFD1 Gene

Pathways & Interactions for CACFD1 Gene

genes like me logo Genes that share pathways with CACFD1: view

Interacting Proteins for CACFD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440832%0d%0a9606.ENSP00000233047%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000440832 Q9UGQ2-FLOWR_HUMAN for CACFD1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CACFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051899 membrane depolarization TAS --
genes like me logo Genes that share ontologies with CACFD1: view

No data available for SIGNOR curated interactions for CACFD1 Gene

Drugs & Compounds for CACFD1 Gene

No Compound Related Data Available

Transcripts for CACFD1 Gene

Unigene Clusters for CACFD1 Gene

Calcium channel flower domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CACFD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -

Relevant External Links for CACFD1 Gene

GeneLoc Exon Structure for
CACFD1
ECgene alternative splicing isoforms for
CACFD1

Expression for CACFD1 Gene

mRNA expression in normal human tissues for CACFD1 Gene

mRNA differential expression in normal tissues according to GTEx for CACFD1 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CACFD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.6), Liver (22.7), and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CACFD1 Gene



SOURCE GeneReport for Unigene cluster for CACFD1 Gene Hs.62003

genes like me logo Genes that share expression patterns with CACFD1: view

Protein tissue co-expression partners for CACFD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CACFD1 Gene

Orthologs for CACFD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACFD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CACFD1 35
  • 86.75 (n)
  • 85.9 (a)
MGC139698 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACFD1 35
  • 81.54 (n)
  • 82.64 (a)
CACFD1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacfd1 35
  • 78.71 (n)
  • 81.33 (a)
Cacfd1 16
Cacfd1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CACFD1 35
  • 99.57 (n)
  • 99.14 (a)
CACFD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cacfd1 35
  • 79.63 (n)
  • 81.48 (a)
oppossum
(Monodelphis domestica)
Mammalia CACFD1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACFD1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF7 35
  • 69.64 (n)
  • 68.15 (a)
C17H9ORF7 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACFD1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacfd1 35
  • 70.34 (n)
  • 71.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68663 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-209e20.5 35
  • 65.99 (n)
  • 63.27 (a)
CACFD1 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4696 35
fruit fly
(Drosophila melanogaster)
Insecta fwe 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F20D1.1 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3337 36
  • 31 (a)
OneToOne
Species with no ortholog for CACFD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACFD1 Gene

ENSEMBL:
Gene Tree for CACFD1 (if available)
TreeFam:
Gene Tree for CACFD1 (if available)

Paralogs for CACFD1 Gene

No data available for Paralogs for CACFD1 Gene

Variants for CACFD1 Gene

Sequence variations from dbSNP and Humsavar for CACFD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3124765 - 133,463,535(-) GCCGC(A/C/G)ATGTT reference, synonymous-codon, utr-variant-5-prime
rs739467 -- 133,461,432(+) TGTAG(G/T)AGAGA intron-variant, utr-variant-5-prime
rs739468 -- 133,461,126(+) GCAGG(G/T)TTTAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs756820 -- 133,461,735(-) ATGCC(A/G)CAAGT intron-variant, utr-variant-5-prime
rs1054380 -- 133,468,879(+) GCTGT(C/G)TGGAC utr-variant-3-prime

Variation tolerance for CACFD1 Gene

Gene Damage Index Score: 1.55; 29.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CACFD1 Gene

Disorders for CACFD1 Gene

Relevant External Links for CACFD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CACFD1

No disorders were found for CACFD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CACFD1 Gene

Publications for CACFD1 Gene

  1. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. (PMID: 19737521) Yao C.K. … Bellen H.J. (Cell 2009) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PMID: 18940312) Yuan X. … Mooser V. (Am. J. Hum. Genet. 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CACFD1 Gene

Sources for CACFD1 Gene

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