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Aliases for CABYR Gene

Aliases for CABYR Gene

  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated 2 3
  • Cancer/Testis Antigen 88 2 3 4
  • FSP2 3 4 6
  • Testis-Specific Calcium-Binding Protein CBP86 3 4
  • Calcium-Binding Protein 86 3 4
  • Fibrousheathin II 3 4
  • Fibrousheathin 2 2 3
  • Fibrousheathin-2 3 4
  • CBP86 3 4
  • FSP-2 3 4
  • CT88 3 4
  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated (Fibrousheathin 2) 3
  • Calcium-Binding Tyrosine-(Y)-Phosphorylation Regulated (Fibrousheathin 2) 3
  • Calcium-Binding Tyrosine Phosphorylation-Regulated Protein 3
  • CABYRc/D 3
  • CABYRa 3
  • CABYRc 3
  • CABYRe 3

External Ids for CABYR Gene

Previous GeneCards Identifiers for CABYR Gene

  • GC18P021611
  • GC18P021450
  • GC18P019970
  • GC18P019972
  • GC18P021718
  • GC18P018575

Summaries for CABYR Gene

Entrez Gene Summary for CABYR Gene

  • To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CABYR Gene

CABYR (Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein kinase binding.

UniProtKB/Swiss-Prot for CABYR Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium

Gene Wiki entry for CABYR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABYR Gene

Genomics for CABYR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CABYR Gene

Start:
24,138,956 bp from pter
End:
24,161,603 bp from pter
Size:
22,648 bases
Orientation:
Plus strand

Genomic View for CABYR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CABYR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABYR Gene

No data available for Regulatory Elements for CABYR Gene

Proteins for CABYR Gene

  • Protein details for CABYR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75952-CABYR_HUMAN
    Recommended name:
    Calcium-binding tyrosine phosphorylation-regulated protein
    Protein Accession:
    O75952
    Secondary Accessions:
    • B2R857
    • Q8WXW5
    • Q9HAY3
    • Q9HAY4
    • Q9HAY5
    • Q9HCY9

    Protein attributes for CABYR Gene

    Size:
    493 amino acids
    Molecular mass:
    52774 Da
    Quaternary structure:
    • Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.

    Alternative splice isoforms for CABYR Gene

neXtProt entry for CABYR Gene

Proteomics data for CABYR Gene at MOPED

Post-translational modifications for CABYR Gene

  • Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CABYR

No data available for DME Specific Peptides for CABYR Gene

Domains for CABYR Gene

Protein Domains for CABYR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CABYR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75952

UniProtKB/Swiss-Prot:

CABYR_HUMAN :
  • O75952
Domain:
  • Contains 1 RIIa domain.
genes like me logo Genes that share domains with CABYR: view

No data available for Gene Families for CABYR Gene

Function for CABYR Gene

Molecular function for CABYR Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium

Gene Ontology (GO) - Molecular Function for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 11820818
GO:0005515 protein binding --
GO:0017124 SH3 domain binding NAS 11820818
GO:0019899 enzyme binding IPI 21274509
GO:0019904 protein domain specific binding --
genes like me logo Genes that share ontologies with CABYR: view

Phenotypes for CABYR Gene

GenomeRNAi human phenotypes for CABYR:
genes like me logo Genes that share phenotypes with CABYR: view

Animal Model Products

miRNA for CABYR Gene

miRTarBase miRNAs that target CABYR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABYR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CABYR Gene

Localization for CABYR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABYR Gene

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABYR Gene COMPARTMENTS Subcellular localization image for CABYR gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 11820818
GO:0005856 cytoskeleton IEA --
GO:0031514 motile cilium IDA 18421703
genes like me logo Genes that share ontologies with CABYR: view

Pathways for CABYR Gene

SuperPathways for CABYR Gene

No Data Available

Interacting Proteins for CABYR Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432870%0d%0a9606.ENSP00000324806%0d%0a9606.ENSP00000344579%0d%0a9606.ENSP00000262013%0d%0a
Selected Interacting proteins: ENSP00000432870 O75952-CABYR_HUMAN for CABYR Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement NAS 18421703
GO:0048240 sperm capacitation NAS 11820818
genes like me logo Genes that share ontologies with CABYR: view

No data available for Pathways by source for CABYR Gene

Compounds for CABYR Gene

(1) HMDB Compounds for CABYR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CABYR: view

Transcripts for CABYR Gene

Unigene Clusters for CABYR Gene

Calcium binding tyrosine-(Y)-phosphorylation regulated:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABYR

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABYR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - -

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CABYR Gene

GeneLoc Exon Structure for
CABYR
ECgene alternative splicing isoforms for
CABYR

Expression for CABYR Gene

mRNA expression in normal human tissues for CABYR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABYR Gene

This gene is overexpressed in Testis (36.0).

Protein differential expression in normal tissues for CABYR Gene

This gene is overexpressed in Testis (42.4) and Ovary (26.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CABYR Gene

SOURCE GeneReport for Unigene cluster for CABYR Gene Hs.511983

mRNA Expression by UniProt/SwissProt for CABYR Gene

O75952-CABYR_HUMAN
Tissue specificity: Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.
genes like me logo Genes that share expressions with CABYR: view

Expression partners for CABYR Gene

In Situ Assay Products

Orthologs for CABYR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABYR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CABYR 35
  • 77.08 (n)
  • 65.17 (a)
CABYR 36
  • 32 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABYR 35
  • 82.16 (n)
  • 70.02 (a)
CABYR 36
  • 32 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabyr 35
  • 78.65 (n)
  • 64.49 (a)
Cabyr 16
Cabyr 36
  • 33 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CABYR 35
  • 99.05 (n)
  • 98.17 (a)
CABYR 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabyr 35
  • 79.06 (n)
  • 65.08 (a)
oppossum
(Monodelphis domestica)
Mammalia CABYR 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CABYR 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CABYR 36
  • 49 (a)
OneToOne
Species with no ortholog for CABYR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CABYR Gene

ENSEMBL:
Gene Tree for CABYR (if available)
TreeFam:
Gene Tree for CABYR (if available)

Paralogs for CABYR Gene

Pseudogenes.org Pseudogenes for CABYR Gene

genes like me logo Genes that share paralogs with CABYR: view

No data available for Paralogs for CABYR Gene

Variants for CABYR Gene

Sequence variations from dbSNP and Humsavar for CABYR Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs169499 -- 24,142,135(+) GCCAA(C/G/T)ATGGT intron-variant
rs176090 -- 24,143,168(+) CTGCT(A/C/T)GAGGG synonymous-codon, reference, intron-variant, utr-variant-5-prime
rs192543 -- 24,138,094(+) TTTTT(G/T)TGttt upstream-variant-2KB
rs204946 -- 24,138,103(+) ttttt(G/T)tgttt upstream-variant-2KB
rs752797 -- 24,155,311(+) ATTAG(C/T)CTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABYR Gene

Variant ID Type Subtype PubMed ID
nsv909459 CNV Gain 21882294
nsv909460 CNV Gain 21882294

Relevant External Links for CABYR Gene

HapMap Linkage Disequilibrium report
CABYR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABYR Gene

Disorders for CABYR Gene

Relevant External Links for CABYR

Genetic Association Database (GAD)
CABYR
Human Genome Epidemiology (HuGE) Navigator
CABYR

No disorders were found for CABYR Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CABYR Gene

Publications for CABYR Gene

  1. Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. (PMID: 16139264) Kim Y.-H. … Herr J.C. (Dev. Biol. 2005) 2 3 4 23
  2. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. (PMID: 11820818) Naaby-Hansen S. … Herr J.C. (Dev. Biol. 2002) 2 3 4 23
  3. CABYR is a novel cancer-testis antigen in lung cancer. (PMID: 17317841) Luo C. … He D. (Clin. Cancer Res. 2007) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. (PMID: 15752768) Hsu H.-C. … Hong Y.-R. (Biochem. Biophys. Res. Commun. 2005) 3 4

Products for CABYR Gene

Sources for CABYR Gene

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