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Aliases for CABYR Gene

Aliases for CABYR Gene

  • Calcium Binding Tyrosine Phosphorylation Regulated 2 3
  • Cancer/Testis Antigen 88 2 3 4
  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated 2 5
  • Testis-Specific Calcium-Binding Protein CBP86 3 4
  • Calcium-Binding Protein 86 3 4
  • Fibrousheathin II 3 4
  • Fibrousheathin 2 2 3
  • Fibrousheathin-2 3 4
  • CBP86 3 4
  • FSP-2 3 4
  • CT88 3 4
  • FSP2 3 4
  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated (Fibrousheathin 2) 3
  • Calcium-Binding Tyrosine-(Y)-Phosphorylation Regulated (Fibrousheathin 2) 3
  • Testis Tissue Sperm-Binding Protein Li 84P 3
  • CABYRc/D 3
  • CABYRa 3
  • CABYRc 3
  • CABYRe 3

External Ids for CABYR Gene

Previous GeneCards Identifiers for CABYR Gene

  • GC18P021611
  • GC18P021450
  • GC18P019970
  • GC18P019972
  • GC18P021718
  • GC18P018575

Summaries for CABYR Gene

Entrez Gene Summary for CABYR Gene

  • To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CABYR Gene

CABYR (Calcium Binding Tyrosine Phosphorylation Regulated) is a Protein Coding gene. Diseases associated with CABYR include suppurative thyroiditis. GO annotations related to this gene include calcium ion binding and enzyme binding.

UniProtKB/Swiss-Prot for CABYR Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

Gene Wiki entry for CABYR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABYR Gene

Genomics for CABYR Gene

Regulatory Elements for CABYR Gene

Enhancers for CABYR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CABYR on UCSC Golden Path with GeneCards custom track

Promoters for CABYR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CABYR on UCSC Golden Path with GeneCards custom track

Genomic Location for CABYR Gene

Chromosome:
18
Start:
24,138,956 bp from pter
End:
24,161,603 bp from pter
Size:
22,648 bases
Orientation:
Plus strand

Genomic View for CABYR Gene

Genes around CABYR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABYR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABYR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABYR Gene

Proteins for CABYR Gene

  • Protein details for CABYR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75952-CABYR_HUMAN
    Recommended name:
    Calcium-binding tyrosine phosphorylation-regulated protein
    Protein Accession:
    O75952
    Secondary Accessions:
    • B2R857
    • Q8WXW5
    • Q9HAY3
    • Q9HAY4
    • Q9HAY5
    • Q9HCY9

    Protein attributes for CABYR Gene

    Size:
    493 amino acids
    Molecular mass:
    52774 Da
    Quaternary structure:
    • Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.

    Alternative splice isoforms for CABYR Gene

neXtProt entry for CABYR Gene

Proteomics data for CABYR Gene at MOPED

Post-translational modifications for CABYR Gene

  • Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CABYR Gene

Domains & Families for CABYR Gene

Protein Domains for CABYR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CABYR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75952

UniProtKB/Swiss-Prot:

CABYR_HUMAN :
  • Contains 1 RIIa domain.
Domain:
  • Contains 1 RIIa domain.
genes like me logo Genes that share domains with CABYR: view

No data available for Gene Families for CABYR Gene

Function for CABYR Gene

Molecular function for CABYR Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

Gene Ontology (GO) - Molecular Function for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with CABYR: view
genes like me logo Genes that share phenotypes with CABYR: view

miRNA for CABYR Gene

miRTarBase miRNAs that target CABYR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CABYR Gene

Localization for CABYR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABYR Gene

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABYR Gene COMPARTMENTS Subcellular localization image for CABYR gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0031514 motile cilium IDA 18421703
genes like me logo Genes that share ontologies with CABYR: view

Pathways & Interactions for CABYR Gene

SuperPathways for CABYR Gene

No Data Available

Interacting Proteins for CABYR Gene

Gene Ontology (GO) - Biological Process for CABYR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CABYR Gene

Drugs & Compounds for CABYR Gene

(1) Drugs for CABYR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CABYR: view

Transcripts for CABYR Gene

Unigene Clusters for CABYR Gene

Calcium binding tyrosine-(Y)-phosphorylation regulated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CABYR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - -

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CABYR Gene

GeneLoc Exon Structure for
CABYR
ECgene alternative splicing isoforms for
CABYR

Expression for CABYR Gene

mRNA expression in normal human tissues for CABYR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABYR Gene

This gene is overexpressed in Testis (x36.0).

Protein differential expression in normal tissues from HIPED for CABYR Gene

This gene is overexpressed in Testis (42.4) and Ovary (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CABYR Gene



SOURCE GeneReport for Unigene cluster for CABYR Gene Hs.511983

mRNA Expression by UniProt/SwissProt for CABYR Gene

O75952-CABYR_HUMAN
Tissue specificity: Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.
genes like me logo Genes that share expression patterns with CABYR: view

Protein tissue co-expression partners for CABYR Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CABYR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABYR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CABYR 35
  • 77.08 (n)
  • 65.17 (a)
CABYR 36
  • 32 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABYR 35
  • 82.16 (n)
  • 70.02 (a)
CABYR 36
  • 32 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabyr 35
  • 78.65 (n)
  • 64.49 (a)
Cabyr 16
Cabyr 36
  • 33 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CABYR 35
  • 99.05 (n)
  • 98.17 (a)
CABYR 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabyr 35
  • 79.06 (n)
  • 65.08 (a)
oppossum
(Monodelphis domestica)
Mammalia CABYR 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CABYR 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CABYR 36
  • 49 (a)
OneToOne
Species with no ortholog for CABYR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CABYR Gene

ENSEMBL:
Gene Tree for CABYR (if available)
TreeFam:
Gene Tree for CABYR (if available)

Paralogs for CABYR Gene

Pseudogenes.org Pseudogenes for CABYR Gene

genes like me logo Genes that share paralogs with CABYR: view

No data available for Paralogs for CABYR Gene

Variants for CABYR Gene

Sequence variations from dbSNP and Humsavar for CABYR Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1049683 - 24,156,969(-) TGTTG(A/C)TTCCC intron-variant, reference, missense
rs3786417 - 24,155,722(+) AGGAA(C/T)GACAC reference, missense, utr-variant-5-prime
rs1049682 - 24,156,844(-) CAGGT(C/T)TGCCT intron-variant, reference, missense
rs35118855 - 24,156,057(+) CATCT(A/G)TTCAT intron-variant, reference, missense
rs169499 -- 24,142,135(+) GCCAA(C/G/T)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABYR Gene

Variant ID Type Subtype PubMed ID
nsv909459 CNV Gain 21882294
nsv909460 CNV Gain 21882294

Variation tolerance for CABYR Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABYR Gene

HapMap Linkage Disequilibrium report
CABYR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABYR Gene

Disorders for CABYR Gene

MalaCards: The human disease database

(1) MalaCards diseases for CABYR Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards
Search CABYR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CABYR

Genetic Association Database (GAD)
CABYR
Human Genome Epidemiology (HuGE) Navigator
CABYR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CABYR
genes like me logo Genes that share disorders with CABYR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CABYR Gene

Publications for CABYR Gene

  1. Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. (PMID: 16139264) Kim Y.-H. … Herr J.C. (Dev. Biol. 2005) 2 3 4 23 67
  2. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. (PMID: 11820818) Naaby-Hansen S. … Herr J.C. (Dev. Biol. 2002) 2 3 23
  3. CABYR is a novel cancer-testis antigen in lung cancer. (PMID: 17317841) Luo C. … He D. (Clin. Cancer Res. 2007) 2 3
  4. Knockdown of CABYR-a/b Increases Chemosensitivity of Human Non-Small Cell Lung Cancer Cells through Inactivation of Akt. (PMID: 24362251) Qian Z. … Xiao X. (Mol. Cancer Res. 2013) 3
  5. The expression and effects the CABYR-c transcript of CABYR gene in hepatocellular carcinoma. (PMID: 22285430) Li H. … Shen L. (Bull Cancer 2012) 3

Products for CABYR Gene

Sources for CABYR Gene

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