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Aliases for CABS1 Gene

Aliases for CABS1 Gene

  • Calcium Binding Protein, Spermatid Associated 1 2 3
  • Calcium-Binding Protein, Spermatid-Specific 1 2 3 5
  • Testis Development Protein NYD-SP26 3 4
  • Casein-Like Phosphoprotein 2 3
  • C4orf35 3 4
  • Calcium-Binding Protein, Sperm-Specific 1 3
  • Chromosome 4 Open Reading Frame 35 2
  • NYD-SP26 3
  • CLPH 3

External Ids for CABS1 Gene

Previous HGNC Symbols for CABS1 Gene

  • C4orf35

Previous GeneCards Identifiers for CABS1 Gene

  • GC04P071202

Summaries for CABS1 Gene

GeneCards Summary for CABS1 Gene

CABS1 (Calcium Binding Protein, Spermatid Associated 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABS1 Gene

Genomics for CABS1 Gene

Regulatory Elements for CABS1 Gene

Enhancers for CABS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CABS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CABS1 Gene

Chromosome:
4
Start:
70,334,954 bp from pter
End:
70,337,116 bp from pter
Size:
2,163 bases
Orientation:
Plus strand

Genomic View for CABS1 Gene

Genes around CABS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABS1 Gene

Proteins for CABS1 Gene

  • Protein details for CABS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KC9-CABS1_HUMAN
    Recommended name:
    Calcium-binding and spermatid-specific protein 1
    Protein Accession:
    Q96KC9
    Secondary Accessions:
    • B2RCB5
    • Q86UE0
    • Q96M17

    Protein attributes for CABS1 Gene

    Size:
    395 amino acids
    Molecular mass:
    43003 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for CABS1 Gene

Proteomics data for CABS1 Gene at MOPED

Post-translational modifications for CABS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CABS1 Gene

Domains & Families for CABS1 Gene

Protein Domains for CABS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CABS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CABS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CABS1 Gene

Function for CABS1 Gene

Phenotypes for CABS1 Gene

genes like me logo Genes that share phenotypes with CABS1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CABS1 Gene

Localization for CABS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABS1 Gene

Cytoplasm. Mitochondrion. Cell projection, cilium, flagellum. Note=Detected in mitochondria of step 17 to 18 spermatids. Associated with the mitochondrial inner membrane in step 18 spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABS1 Gene COMPARTMENTS Subcellular localization image for CABS1 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CABS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CABS1: view

Pathways & Interactions for CABS1 Gene

SuperPathways for CABS1 Gene

No Data Available

Interacting Proteins for CABS1 Gene

Gene Ontology (GO) - Biological Process for CABS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CABS1 Gene

Drugs & Compounds for CABS1 Gene

No Compound Related Data Available

Transcripts for CABS1 Gene

mRNA/cDNA for CABS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABS1 Gene

Calcium-binding protein, spermatid-specific 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CABS1 Gene

No ASD Table

Relevant External Links for CABS1 Gene

GeneLoc Exon Structure for
CABS1
ECgene alternative splicing isoforms for
CABS1

Expression for CABS1 Gene

mRNA expression in normal human tissues for CABS1 Gene

mRNA differential expression in normal tissues according to GTEx for CABS1 Gene

This gene is overexpressed in Testis (x52.3).

Protein differential expression in normal tissues from HIPED for CABS1 Gene

This gene is overexpressed in Ovary (54.1) and Testis (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CABS1 Gene



SOURCE GeneReport for Unigene cluster for CABS1 Gene Hs.120316

genes like me logo Genes that share expression patterns with CABS1: view

Protein tissue co-expression partners for CABS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CABS1 Gene

Orthologs for CABS1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CABS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CABS1 35
  • 80.45 (n)
  • 66.93 (a)
CABS1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABS1 35
  • 79.73 (n)
  • 66.41 (a)
CABS1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabs1 35
  • 75.06 (n)
  • 61.95 (a)
Cabs1 16
Cabs1 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CABS1 35
  • 99.41 (n)
  • 98.73 (a)
CABS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabs1 35
  • 74.18 (n)
  • 62.18 (a)
Species with no ortholog for CABS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CABS1 Gene

ENSEMBL:
Gene Tree for CABS1 (if available)
TreeFam:
Gene Tree for CABS1 (if available)

Paralogs for CABS1 Gene

No data available for Paralogs for CABS1 Gene

Variants for CABS1 Gene

Sequence variations from dbSNP and Humsavar for CABS1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3796706 - 70,335,265(-) TGATT(G/T)GAGTT reference, missense
rs1351419 - 70,335,671(+) TTCCA(C/T)TATTC reference, missense
rs2291182 - 70,335,931(+) GTATT(G/T)GGATG reference, missense
rs13039 -- 70,336,226(+) GATTT(A/G)AAAGC reference, synonymous-codon
rs2332001 -- 70,334,682(+) CCTGG(A/C)AGTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CABS1 Gene

Variant ID Type Subtype PubMed ID
nsv829964 CNV Gain 17160897
nsv879467 CNV Loss 21882294
nsv461554 CNV Loss 19166990
nsv470046 CNV Loss 18288195
dgv321n21 CNV Loss 19592680

Variation tolerance for CABS1 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABS1 Gene

HapMap Linkage Disequilibrium report
CABS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABS1 Gene

Disorders for CABS1 Gene

Relevant External Links for CABS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CABS1

No disorders were found for CABS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CABS1 Gene

Publications for CABS1 Gene

  1. CLPH, a novel casein kinase 2-phosphorylated disordered protein, is specifically associated with postmeiotic germ cells in rat spermatogenesis. (PMID: 19271754) Calvel P. … Pineau C. (J. Proteome Res. 2009) 2 3 67
  2. CABS1 is a novel calcium-binding protein specifically expressed in elongate spermatids of mice. (PMID: 19208547) Kawashima A. … Okamura N. (Biol. Reprod. 2009) 2 3
  3. Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif. (PMID: 25632019) St Laurent C.D. … Befus A.D. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CABS1 Gene

Sources for CABS1 Gene

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