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Aliases for CABP7 Gene

Aliases for CABP7 Gene

  • Calcium Binding Protein 7 2 3
  • Calneuron II 3 4
  • Calneuron-2 3 4
  • CALN2 3 4
  • Calcium-Binding Protein 7 3
  • Calneuron 2 3
  • CaBP7 4

External Ids for CABP7 Gene

Previous GeneCards Identifiers for CABP7 Gene

  • GC22P028440
  • GC22P030116
  • GC22P013055

Summaries for CABP7 Gene

GeneCards Summary for CABP7 Gene

CABP7 (Calcium Binding Protein 7) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALN1.

UniProtKB/Swiss-Prot for CABP7 Gene

  • Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABP7 Gene

Genomics for CABP7 Gene

Regulatory Elements for CABP7 Gene

Genomic Location for CABP7 Gene

Start:
29,720,084 bp from pter
End:
29,731,839 bp from pter
Size:
11,756 bases
Orientation:
Plus strand

Genomic View for CABP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABP7 Gene

Proteins for CABP7 Gene

  • Protein details for CABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V35-CABP7_HUMAN
    Recommended name:
    Calcium-binding protein 7
    Protein Accession:
    Q86V35
    Secondary Accessions:

    Protein attributes for CABP7 Gene

    Size:
    215 amino acids
    Molecular mass:
    24453 Da
    Quaternary structure:
    • Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for CABP7 Gene

neXtProt entry for CABP7 Gene

Proteomics data for CABP7 Gene at MOPED

Post-translational modifications for CABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CABP7 Gene

Domains for CABP7 Gene

Gene Families for CABP7 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CABP7 Gene

Suggested Antigen Peptide Sequences for CABP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V35

UniProtKB/Swiss-Prot:

CABP7_HUMAN :
  • Q86V35
Domain:
  • The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with CABP7: view

Function for CABP7 Gene

Molecular function for CABP7 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

Gene Ontology (GO) - Molecular Function for CABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CABP7: view

Animal Model Products

CRISPR Products

miRNA for CABP7 Gene

miRTarBase miRNAs that target CABP7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CABP7 Gene

Localization for CABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABP7 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABP7 Gene COMPARTMENTS Subcellular localization image for CABP7 gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032588 trans-Golgi network membrane IDA 19338761
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CABP7: view

Pathways for CABP7 Gene

SuperPathways for CABP7 Gene

genes like me logo Genes that share pathways with CABP7: view

Pathways by source for CABP7 Gene

1 Qiagen pathway for CABP7 Gene

Interacting Proteins for CABP7 Gene

Gene Ontology (GO) - Biological Process for CABP7 Gene

None

Transcripts for CABP7 Gene

mRNA/cDNA for CABP7 Gene

(19) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABP7 Gene

Calcium binding protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABP7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CABP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABP7 Gene

No ASD Table

Relevant External Links for CABP7 Gene

GeneLoc Exon Structure for
CABP7
ECgene alternative splicing isoforms for
CABP7

Expression for CABP7 Gene

mRNA expression in normal human tissues for CABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABP7 Gene

This gene is overexpressed in Brain - Hippocampus (18.6) and Brain - Cerebellum (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CABP7 Gene

SOURCE GeneReport for Unigene cluster for CABP7 Gene Hs.643608

genes like me logo Genes that share expressions with CABP7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CABP7 Gene

Orthologs for CABP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CABP7 35
  • 95.09 (n)
  • 94.21 (a)
CABP7 36
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CABP7 35
  • 93.11 (n)
  • 100 (a)
CABP7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABP7 35
  • 93.8 (n)
  • 100 (a)
CABP7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabp7 35
  • 94.11 (n)
  • 100 (a)
Cabp7 16
Cabp7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CABP7 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabp7 35
  • 93.18 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CABP7 35
  • 91.81 (n)
  • 98.32 (a)
CABP7 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cabp7 35
  • 77.52 (n)
  • 86.05 (a)
zebrafish
(Danio rerio)
Actinopterygii CABP7 (2 of 2) 36
  • 82 (a)
OneToMany
cabp7b 35
  • 72.93 (n)
  • 77.93 (a)
cabp7b 36
  • 77 (a)
OneToMany
Species with no ortholog for CABP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CABP7 Gene

ENSEMBL:
Gene Tree for CABP7 (if available)
TreeFam:
Gene Tree for CABP7 (if available)

Paralogs for CABP7 Gene

Paralogs for CABP7 Gene

Selected SIMAP similar genes for CABP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CABP7: view

Variants for CABP7 Gene

Sequence variations from dbSNP and Humsavar for CABP7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs140092 -- 29,726,290(+) GCCTC(C/T)GCCCA intron-variant
rs140093 -- 29,727,225(+) GGATC(-/TAAGGATC)CGAGC intron-variant
rs140094 -- 29,728,380(+) GGTCA(C/T)GGCCC intron-variant
rs140095 -- 29,728,461(+) CCTGG(C/T)ACTTG intron-variant
rs140096 -- 29,728,625(+) CCTCC(A/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABP7 Gene

Variant ID Type Subtype PubMed ID
dgv4953n71 CNV Loss 21882294
nsv515720 CNV Gain+Loss 19592680
nsv471194 CNV Gain 18288195
nsv471195 CNV Loss 18288195
nsv914967 CNV Loss 21882294

Relevant External Links for CABP7 Gene

HapMap Linkage Disequilibrium report
CABP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABP7 Gene

Disorders for CABP7 Gene

No disorders were found for CABP7 Gene.

No data available for UniProtKB/Swiss-Prot for CABP7 Gene

Publications for CABP7 Gene

  1. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PMID: 11785943) Haeseleer F. … Palczewski K. (Biochem. Biophys. Res. Commun. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PMID: 19338761) McCue H.V. … Haynes L.P. (Biochem. Biophys. Res. Commun. 2009) 3 4
  4. Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking. (PMID: 22989873) McCue H.V. … Haynes L.P. (J. Biol. Chem. 2012) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CABP7 Gene

Sources for CABP7 Gene

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