CABP7 Gene
protein-coding GIFtS: 43
GCID: GC22P030116
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calcium binding protein 7
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Aliases
for CABP7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Binding Protein 71 2 | | Calneuron 22 | | Calneuron II2 3 | | Calneuron-23 | | CALN22 3 | | CaBP73 | | MGC577931 | | Calneuron-23 | | Calcium-Binding Protein 72 | | |
Export aliases for CABP7 gene to outside databasesPrevious GC identifers: GC22P028440 GC22P013055 |
Summaries
for CABP7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CABP7_HUMAN, Q86V35Function: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting itsactivity (By similarity)
|
Genomic Views
for CABP7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CABP7 gene promoter:
Max1 USF1 NF-1 GATA-3 NRSF form 1 MyoD NRSF form 2 USF-1 MRF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CABP7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2CABP7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P030116: view genomic region
(about GC identifiers)
Start:
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30,116,073 bp from pter |
End:
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30,127,828 bp from pter |
Size:
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11,756 bases |
Orientation:
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plus strand |
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Proteins
for CABP7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CABP7_HUMAN, Q86V35 (See
protein sequence)Recommended Name: Calcium-binding protein 7 Size: 215 amino acids; 24453 Da
Subunit: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (Bysimilarity)
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable).Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein (Probable)
1 PDB 3D structure from  and Proteopedia  for CABP7:2LV7 (3D)
Explore the universe of human proteins at neXtProt for CABP7: NX_Q86V35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86V35
CABP7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872333.1
ENSEMBL proteins: ENSP00000216144
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CABP7 for ontologies About GeneDecksing
CABP7 Antibody Products:
Assay Products for CABP7: |
Protein
Domains /
Families
for CABP7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CABP7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86V35ProtoNet protein and cluster: Q86V35 UniProtKB/Swiss-Prot: CABP7_HUMAN, Q86V35Domain: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targetingSimilarity: Contains 2 EF-hand domains |
Function
for CABP7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CABP7_HUMAN, Q86V35Function: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting itsactivity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CABP7 (NM_182527) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABP7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CABP7 for ontologies About GeneDecksing
|
Pathways & Interactions
for CABP7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Visual Cycle in Retinal Rods | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CABP7
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CABP7
|
Drugs & Compounds
for CABP7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CABP7
Search CenterWatch for drugs/clinical trials and news about CABP7
|
Transcripts
for CABP7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CABP7 gene: NM_182527.2 Unigene Cluster for CABP7: Calcium binding protein 7 Hs.643608 [show with all ESTs]Unigene Representative Sequence: BC0518051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000216144(uc003agl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CABP7 (NM_182527) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABP7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP7 |
Additional cDNA sequence: BC051805.1 3 DOTS entries: DT.65285832 DT.100026715 DT.456154 19 AceView cDNA sequences: BC051805 NM_182527 AI989906 BM126317 BU167479 BX488512 BM069656 BM126037 BI117398 CK818911 AA351919 BM548677 BF941601 Z41943 BM069879 BM548414 BU585277 CK818912 H88694
GeneLoc Exon Structure
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Expression
for CABP7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CABP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACTATTTT
About this image
See CABP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CABP7
SOURCE GeneReport for Unigene cluster: Hs.643608
SABiosciences Custom PCR Arrays for CABP7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABP7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CABP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP7 |
Orthologs
for CABP7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CABP7 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for CABP7 (if available)
TreeFam Gene Tree for CABP7 (if available) |
Paralogs
for CABP7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CABP7 gene
- CALML32 CABP52 CABP12 TNNC12 CALM32 CABP42 CABP22 CALM12
- TNNC22 CALML62 CALML52 CALML42 CALN12 CALM22
4 SIMAP similar genes for CABP7 using alignment to 1 protein entry: CABP7_HUMAN:CALN1 CABP1 CETN1 CABP5
CABP7 for paralogs About GeneDecksing
|
Genomic Variants
for CABP7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CABP7 (30116073 - 30127828 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CABP7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABP7 |
|
Disorders
/ Diseases
for CABP7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CABP7 for disorders About GeneDecksing
1  disease for CABP7: About MalaCardsretinitis
Export disorders for CABP7 gene to outside databases
|
Publications
for CABP7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CABP7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CABP7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PubMed id 19338761)1, 2 McCue H.V.... Haynes L.P. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PubMed id 11785943)1, 3 Haeseleer F....Palczewski K. (2002)
- Solution NMR structure of the Ca2+-bound N-terminal do main of CaBP7: a regulator of golgi trafficking. (PubMed id 22989873)1 McCue H.V....Haynes L.P. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)
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External Searches for CABP7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CABP7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CABP7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CABP7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CABP7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CABP7 gene:
Search GeneIP for patents involving CABP7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CABP7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CABP7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABP7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABP7 | | | OriGene Protein Over-expression Lysate for CABP7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CABP7 | | OriGene 3'-UTR Clone for CABP7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CABP7 | | OriGene Custom Protein Services for CABP7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABP7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABP7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABP7 |
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 |  |  |  | |
| | | | Search Tocris compounds for CABP7 |
| |  |  |  |  | | | | | | Recombinant Protein for CABP7 |
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 | | | CABP7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP7 |
|  |  |  | | | | ThermoFisher Antibody for CABP7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP7 |
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