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Aliases for CABP7 Gene

Aliases for CABP7 Gene

  • Calcium Binding Protein 7 2 3 5
  • Calneuron II 3 4
  • CALN2 3 4
  • Calcium-Binding Protein 7 3
  • Calneuron 2 3
  • Calneuron-2 4
  • CaBP7 4

External Ids for CABP7 Gene

Previous GeneCards Identifiers for CABP7 Gene

  • GC22P028440
  • GC22P030116
  • GC22P013055

Summaries for CABP7 Gene

GeneCards Summary for CABP7 Gene

CABP7 (Calcium Binding Protein 7) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALN1.

UniProtKB/Swiss-Prot for CABP7 Gene

  • Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABP7 Gene

Genomics for CABP7 Gene

Regulatory Elements for CABP7 Gene

Enhancers for CABP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F029795 0.7 Ensembl ENCODE 5 +78.9 78901 7.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 HORMAD2-AS1 ASCC2 ZMAT5 CABP7 UQCR10 LOC105372986
GH22F029368 1.2 FANTOM5 Ensembl ENCODE 1.4 -350.5 -350539 1.3 HDGF ZNF266 MAX ZIC2 ZNF121 PRDM10 FOS ZNF263 ZNF362 HLF AP1B1 RASL10A SNORD125 NEFH ZNRF3 CABP7 MIR3653 LOC102723305
GH22F029727 0.9 Ensembl ENCODE 0.4 +7.2 7183 0.3 CTCF ESRRA MAX CEBPG ZIC2 RAD21 GLIS2 SMC3 NR2F6 CREM HORMAD2-AS1 ASCC2 CABP7 GC22P029759
GH22F029733 0.8 ENCODE 0.4 +13.7 13727 1.3 PKNOX1 TAL1 MAX EBF1 ZIC2 POLR2A ZBTB48 NCOR1 PATZ1 EED MTMR3 UQCR10 ASCC2 CABP7 GC22P029759
GH22F029734 0.7 ENCODE 0.3 +15.0 15024 0.6 CTCF MAZ TEAD4 UQCR10 CABP7 GC22P029759
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CABP7 on UCSC Golden Path with GeneCards custom track

Promoters for CABP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001842863 316 801 SOX5 SCRT1 SOX13 SUZ12 BHLHE40 CEBPB CEBPG ZNF623 RAD21 ZNF335

Genomic Location for CABP7 Gene

Chromosome:
22
Start:
29,720,084 bp from pter
End:
29,731,839 bp from pter
Size:
11,756 bases
Orientation:
Plus strand

Genomic View for CABP7 Gene

Genes around CABP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABP7 Gene

Proteins for CABP7 Gene

  • Protein details for CABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V35-CABP7_HUMAN
    Recommended name:
    Calcium-binding protein 7
    Protein Accession:
    Q86V35

    Protein attributes for CABP7 Gene

    Size:
    215 amino acids
    Molecular mass:
    24453 Da
    Quaternary structure:
    • Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for CABP7 Gene

neXtProt entry for CABP7 Gene

Post-translational modifications for CABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CABP7 Gene

Domains & Families for CABP7 Gene

Gene Families for CABP7 Gene

Protein Domains for CABP7 Gene

Suggested Antigen Peptide Sequences for CABP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V35

UniProtKB/Swiss-Prot:

CABP7_HUMAN :
  • The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
Domain:
  • The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with CABP7: view

Function for CABP7 Gene

Molecular function for CABP7 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

Gene Ontology (GO) - Molecular Function for CABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CABP7: view
genes like me logo Genes that share phenotypes with CABP7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CABP7 Gene

Localization for CABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABP7 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABP7 Gene COMPARTMENTS Subcellular localization image for CABP7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CABP7: view

Pathways & Interactions for CABP7 Gene

SuperPathways for CABP7 Gene

SuperPathway Contained pathways
1 Visual Cycle in Retinal Rods
genes like me logo Genes that share pathways with CABP7: view

Pathways by source for CABP7 Gene

1 Qiagen pathway for CABP7 Gene

Gene Ontology (GO) - Biological Process for CABP7 Gene

None

No data available for SIGNOR curated interactions for CABP7 Gene

Transcripts for CABP7 Gene

mRNA/cDNA for CABP7 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABP7 Gene

Calcium binding protein 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABP7 Gene

No ASD Table

Relevant External Links for CABP7 Gene

GeneLoc Exon Structure for
CABP7
ECgene alternative splicing isoforms for
CABP7

Expression for CABP7 Gene

mRNA expression in normal human tissues for CABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABP7 Gene

This gene is overexpressed in Brain - Hippocampus (x18.6) and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for CABP7 Gene

This gene is overexpressed in Testis (24.8), Gallbladder (8.3), Fetal gut (7.4), and Fetal ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CABP7 Gene



NURSA nuclear receptor signaling pathways regulating expression of CABP7 Gene:

CABP7

SOURCE GeneReport for Unigene cluster for CABP7 Gene:

Hs.643608
genes like me logo Genes that share expression patterns with CABP7: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CABP7 Gene

Orthologs for CABP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CABP7 34 35
  • 95.09 (n)
mouse
(Mus musculus)
Mammalia Cabp7 34 16 35
  • 94.11 (n)
dog
(Canis familiaris)
Mammalia CABP7 34 35
  • 93.8 (n)
rat
(Rattus norvegicus)
Mammalia Cabp7 34
  • 93.18 (n)
cow
(Bos Taurus)
Mammalia CABP7 34 35
  • 93.11 (n)
oppossum
(Monodelphis domestica)
Mammalia CABP7 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CABP7 34 35
  • 91.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cabp7 34
  • 77.52 (n)
zebrafish
(Danio rerio)
Actinopterygii CABP7 (2 of 2) 35
  • 82 (a)
OneToMany
cabp7b 34 35
  • 72.93 (n)
Species where no ortholog for CABP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CABP7 Gene

ENSEMBL:
Gene Tree for CABP7 (if available)
TreeFam:
Gene Tree for CABP7 (if available)

Paralogs for CABP7 Gene

Paralogs for CABP7 Gene

(4) SIMAP similar genes for CABP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CABP7: view

Variants for CABP7 Gene

Sequence variations from dbSNP and Humsavar for CABP7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111418302 -- 29,725,380(+) AAGAG(C/T)CAGAG intron-variant
rs111587147 -- 29,730,548(+) AGGCT(A/G)CGCCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs111597500 -- 29,727,209(+) GGTGT(-/TAAGGATC)TAAGG intron-variant
rs111811492 -- 29,728,388(+) CCCAC(C/T)TGCTG intron-variant
rs111846036 -- 29,730,822(+) CTGCT(C/G)GTCCC intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CABP7 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv471194 CNV gain 18288195
nsv471195 CNV loss 18288195
nsv478406 CNV novel sequence insertion 20440878
nsv515720 CNV gain+loss 19592680

Variation tolerance for CABP7 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CABP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABP7 Gene

Disorders for CABP7 Gene

Relevant External Links for CABP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CABP7

No disorders were found for CABP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CABP7 Gene

Publications for CABP7 Gene

  1. Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking. (PMID: 22989873) McCue H.V. … Haynes L.P. (J. Biol. Chem. 2012) 3 4 64
  2. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PMID: 19338761) McCue H.V. … Haynes L.P. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PMID: 11785943) Haeseleer F. … Palczewski K. (Biochem. Biophys. Res. Commun. 2002) 2 3 64
  5. Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells. (PMID: 25717182) Rajamanoharan D. … Haynes L.P. (Mol. Biol. Cell 2015) 3 64

Products for CABP7 Gene

Sources for CABP7 Gene

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