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Aliases for CABP7 Gene

Aliases for CABP7 Gene

  • Calcium Binding Protein 7 2 3 5
  • Calneuron II 3 4
  • Calneuron-2 3 4
  • CALN2 3 4
  • Calneuron 2 3
  • CaBP7 4

External Ids for CABP7 Gene

Previous GeneCards Identifiers for CABP7 Gene

  • GC22P028440
  • GC22P030116
  • GC22P013055

Summaries for CABP7 Gene

GeneCards Summary for CABP7 Gene

CABP7 (Calcium Binding Protein 7) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALN1.

UniProtKB/Swiss-Prot for CABP7 Gene

  • Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABP7 Gene

Genomics for CABP7 Gene

Regulatory Elements for CABP7 Gene

Enhancers for CABP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CABP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CABP7 Gene

29,720,084 bp from pter
29,731,839 bp from pter
11,756 bases
Plus strand

Genomic View for CABP7 Gene

Genes around CABP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABP7 Gene

Proteins for CABP7 Gene

  • Protein details for CABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 7
    Protein Accession:

    Protein attributes for CABP7 Gene

    215 amino acids
    Molecular mass:
    24453 Da
    Quaternary structure:
    • Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for CABP7 Gene

neXtProt entry for CABP7 Gene

Proteomics data for CABP7 Gene at MOPED

Post-translational modifications for CABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CABP7 Gene

Domains & Families for CABP7 Gene

Gene Families for CABP7 Gene

Protein Domains for CABP7 Gene

Suggested Antigen Peptide Sequences for CABP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
  • The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with CABP7: view

Function for CABP7 Gene

Molecular function for CABP7 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
genes like me logo Genes that share phenotypes with CABP7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CABP7 Gene

Localization for CABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABP7 Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for CABP7 Gene COMPARTMENTS Subcellular localization image for CABP7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032588 trans-Golgi network membrane IEA,IDA 19338761
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CABP7: view

Pathways & Interactions for CABP7 Gene

SuperPathways for CABP7 Gene

genes like me logo Genes that share pathways with CABP7: view

Pathways by source for CABP7 Gene

1 Qiagen pathway for CABP7 Gene

Interacting Proteins for CABP7 Gene

Gene Ontology (GO) - Biological Process for CABP7 Gene


No data available for SIGNOR curated interactions for CABP7 Gene

Drugs & Compounds for CABP7 Gene

No Compound Related Data Available

Transcripts for CABP7 Gene

mRNA/cDNA for CABP7 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABP7 Gene

Calcium binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CABP7 Gene

No ASD Table

Relevant External Links for CABP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CABP7 Gene

mRNA expression in normal human tissues for CABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABP7 Gene

This gene is overexpressed in Brain - Hippocampus (x18.6) and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for CABP7 Gene

This gene is overexpressed in Testis (24.8), Gallbladder (8.3), Fetal gut (7.4), and Fetal ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CABP7 Gene

SOURCE GeneReport for Unigene cluster for CABP7 Gene Hs.643608

genes like me logo Genes that share expression patterns with CABP7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CABP7 Gene

Orthologs for CABP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CABP7 35
  • 93.11 (n)
  • 100 (a)
CABP7 36
  • 98 (a)
(Canis familiaris)
Mammalia CABP7 35
  • 93.8 (n)
  • 100 (a)
CABP7 36
  • 100 (a)
(Mus musculus)
Mammalia Cabp7 35
  • 94.11 (n)
  • 100 (a)
Cabp7 16
Cabp7 36
  • 100 (a)
(Pan troglodytes)
Mammalia CABP7 35
  • 95.09 (n)
  • 94.21 (a)
CABP7 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Cabp7 35
  • 93.18 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia CABP7 36
  • 59 (a)
(Gallus gallus)
Aves CABP7 35
  • 91.81 (n)
  • 98.32 (a)
CABP7 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cabp7 35
  • 77.52 (n)
  • 86.05 (a)
(Danio rerio)
Actinopterygii cabp7b 35
  • 72.93 (n)
  • 77.93 (a)
CABP7 (2 of 2) 36
  • 82 (a)
cabp7b 36
  • 77 (a)
Species with no ortholog for CABP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CABP7 Gene

Gene Tree for CABP7 (if available)
Gene Tree for CABP7 (if available)

Paralogs for CABP7 Gene

Paralogs for CABP7 Gene

(4) SIMAP similar genes for CABP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CABP7: view

Variants for CABP7 Gene

Sequence variations from dbSNP and Humsavar for CABP7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7287478 -- 29,726,668(+) GGGAA(C/T)AGCTT intron-variant, upstream-variant-2KB
rs2527347 -- 29,720,703(+) CACCC(C/T)GGGGC intron-variant
rs7510662 -- 29,729,771(+) GGTGG(A/C)TCTGA utr-variant-3-prime
rs140092 -- 29,726,290(+) GCCTC(C/T)GCCCA intron-variant, upstream-variant-2KB
rs140093 -- 29,727,225(+) GGATC(-/TAAGGATC)CGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABP7 Gene

Variant ID Type Subtype PubMed ID
dgv4953n71 CNV Loss 21882294
nsv515720 CNV Gain+Loss 19592680
nsv471194 CNV Gain 18288195
nsv471195 CNV Loss 18288195
nsv914967 CNV Loss 21882294

Variation tolerance for CABP7 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CABP7 Gene

Disorders for CABP7 Gene

Relevant External Links for CABP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CABP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CABP7 Gene

Publications for CABP7 Gene

  1. Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking. (PMID: 22989873) McCue H.V. … Haynes L.P. (J. Biol. Chem. 2012) 3 4 67
  2. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PMID: 11785943) Haeseleer F. … Palczewski K. (Biochem. Biophys. Res. Commun. 2002) 2 3
  3. Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells. (PMID: 25717182) Rajamanoharan D. … Haynes L.P. (Mol. Biol. Cell 2015) 3
  4. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PMID: 19338761) McCue H.V. … Haynes L.P. (Biochem. Biophys. Res. Commun. 2009) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CABP7 Gene

Sources for CABP7 Gene