CABP5 Gene
protein-coding GIFtS : 47
GCID: GC19 M048533
calcium binding protein 5 (Previous name: calcium binding protein 3 ) (Previous symbol: CABP3 )
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Aliasesfor CABP5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Calcium Binding Protein 5 1 2 Calcium-Binding Protein 32 CABP31 2 3 5 Calcium-Binding Protein 52 CaBP31 CaBP53 Calcium Binding Protein 31
Export aliases for CABP5 gene to outside databases Previous GC identifers: GC19M049177 GC19M048901 GC19M053209 GC19M053226 GC19M053228 GC19M053229 GC19M044915
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Summariesfor CABP5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CABP5 : The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. (provided by RefSeq, Oct 2009) UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 Function : Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activationto more depolarized membrane potentials. Involved in the transmission of light signals (By similarity)
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Genomic Viewsfor CABP5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CABP5 gene promoter: AREB6 CHOP-10 AP-1 FOXO4 SEF-1 (1) Sox9 Cdc5 GATA-2 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for CABP5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3 CABP5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M048533: view genomic region
(about GC identifiers )
Start:
48,533,210 bp from pter
End:
48,547,304 bp from pter
Size:
14,095 bases
Orientation:
minus strand
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Proteinsfor CABP5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 (See
protein sequence )Recommended Name: Calcium-binding protein 5 Size : 173 amino acids; 19826 Da
Subunit : Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner (By similarity)
Subcellular location : Cytoplasm
Secondary accessions : A0AUY4Explore the universe of human proteins at neXtProt for CABP5: NX_Q9NP86 CABP5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_062829.1 ENSEMBL proteins: ENSP00000293255 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
CABP5 for ontologies About GeneDecksing CABP5 Antibody Products: Assay Products for CABP5:
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Protein
Domains / Familiesfor CABP5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CABP5 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NP86 ProtoNet protein and cluster: Q9NP86
UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 Similarity : Contains 4 EF-hand domains
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Functionfor CABP5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 Function : Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activationto more depolarized membrane potentials. Involved in the transmission of light signals (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CABP5 (NM_019855 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABP5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CABP5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP5
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
CABP5 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for CABP5 :
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Pathways & Interactionsfor CABP5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Visual Cycle in Retinal Rods
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CABP5 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CABP5 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for CABP5 (Q9NP86 3 ENSP00000293255 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
CABP5 for ontologies About GeneDecksing
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Drugs & Compoundsfor CABP5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CABP5 Search CenterWatch for drugs/clinical trials and news about CABP5
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Transcriptsfor CABP5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CABP5 gene (2 alternative transcripts): NM_019855.4 NM_016367.1 Unigene Cluster for CABP5:
Calcium binding protein 5 Hs.117694 [show with all ESTs ] Unigene Representative Sequence: NM_019855 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000293255 (uc002phu.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CABP5 (NM_019855 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABP5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CABP5
Additional cDNA sequence: AF169159.1 BC126133.1 BC126135.1
2 DOTS entries : DT.40308759 DT.97835383
16 AceView cDNA sequences :
BM709662 BQ640522 BQ639616 BQ185108 AF169159 H30054 BQ637976 BM709648 BU734154 NM_019855 BX490518 BM709781 BM675997 AA318398 H30055 AF169158 GeneLoc Exon Structure
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Expression for CABP5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CABP5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAACAAAACC
About this image CABP5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CABP5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CABP5 SOURCE GeneReport for Unigene cluster: Hs.117694 UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 Tissue specificity : Retina SABiosciences Custom PCR Arrays for CABP5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CABP5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat CABP5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CABP5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CABP5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP5
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Orthologsfor CABP5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CABP5 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
CABP56
--
87(a)
1 ↔ 1
GL343287.1(684787-697907)
zebrafish (Danio rerio)
Actinopterygii
BC059438.12
--
78.82(n)
 
393671 BC059438.1
fruit fly (Drosophila melanogaster)
Insecta
CG135266
--
25(a)
1 → many
2R(18642745-18643401)
ENSEMBL Gene Tree for CABP5 (if available)TreeFam Gene Tree for CABP5 (if available)
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Paralogsfor CABP5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CABP5 gene CALML3 2 CABP1 2 TNNC1 2 CALM3 2 CABP4 2 CABP2 2 CALM1 2 TNNC2 2 CALML6 2 CALML5 2 CALML4 2 CABP7 2 CALN1 2 CALM2 2 18/22 SIMAP similar genes for CABP5 using alignment to 1 protein entry: CABP5_HUMAN (see all similar genes ):CABP1 CABP2 CABP4 CALM3 CALML3 CALM1 CALM2 CALN1 MYL6 CETN1 CETN2 TNNC1 TNNC2 CETN3 CALML5 MYL9 CABP7 MRLC3
CABP5 for paralogs About GeneDecksing
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Genomic Variantsfor CABP5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CABP5 (48533210 - 48547304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for CABP5 3 CNVs : 47965 5105 32261 2 Indels : 73396 102857
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CABP5
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Disorders
/ Diseasesfor CABP5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CABP5 for disorders About GeneDecksing
OMIM gene information: 607315
OMIM disorders : --2 diseases for CABP5 : About MalaCards neuronitis retinitis 1 disease from the University of Copenhagen DISEASES database for CABP5 :Amebiasis Export disorders for CABP5 gene to outside databases
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Publicationsfor CABP5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CABP5 gene integrated from 9 sources : (articles sorted by number of sources associating them with CABP5) Utopia : connect your pdf to the dynamic world of online information
Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670) 1 , 2 , 3 Haeseleer F....Palczewski K. (2000) Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PubMed id 19338761) 1 , 2 McCue H.V.... Haynes L.P. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease. (PubMed id 11108966) 1 , 2 Sokal I....Palczewski K. (2000) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PubMed id 11785943) 1 Haeseleer F....Palczewski K. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996) Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098) 1 Adams M.D....White O. (1995)
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External Searches for CABP5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CABP5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CABP5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CABP5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CABP5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CABP5 gene: Search GeneIP for patents involving CABP5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CABP5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CABP5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CABP5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CABP5 OriGene Protein Over-expression Lysate for CABP5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CABP5 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CABP5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CABP5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CABP5 OriGene Custom Protein Services for CABP5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABP5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CABP5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CABP5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CABP5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CABP5
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CABP5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP5
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CABP5
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Aliases for CABP5
Databases for CABP5
Disorders / Diseases for CABP5
Domains / Families for CABP5
Drugs / Compounds for CABP5
Expression for CABP5
Function for CABP5
Genomic Views for CABP5
Intellectual Property for CABP5
Orthologs for CABP5
Paralogs for CABP5
Pathways / Interactions for CABP5
Products for CABP5
Proteins for CABP5
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Search Box for CABP5
Summaries for CABP5
Transcripts for CABP5
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