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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CABP5 Gene

protein-coding   GIFtS: 47
GCID: GC19M048533

calcium binding protein 5

(Previous name: calcium binding protein 3 )
(Previous symbol: CABP3)
 Explore 2 diseases affiliated with
CABP5 via our new
 Human Malady Compendium 
Biological research products
for CABP5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Calcium Binding Protein 51 2     Calcium-Binding Protein 32
CABP31 2 3 5     Calcium-Binding Protein 52
CaBP31     CaBP53
Calcium Binding Protein 31     

External Ids:    HGNC: 137141   Entrez Gene: 563442   Ensembl: ENSG000001055077   OMIM: 6073155   UniProtKB: Q9NP863   

Export aliases for CABP5 gene to outside databases

Previous GC identifers: GC19M049177 GC19M048901 GC19M053209 GC19M053226 GC19M053228 GC19M053229 GC19M044915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CABP5:
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin.
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of
this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer
of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. (provided by
RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86
Function: Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation
to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CABP5 gene promoter:
         AREB6   CHOP-10   AP-1   FOXO4   SEF-1 (1)   Sox9   Cdc5   GATA-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCABP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CABP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

CABP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABP5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048533:  view genomic region     (about GC identifiers)

Start:
48,533,210 bp from pter      End:
48,547,304 bp from pter
Size:
14,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86 (See protein sequence)
Recommended Name: Calcium-binding protein 5  
Size: 173 amino acids; 19826 Da
Subunit: Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: A0AUY4

Explore the universe of human proteins at neXtProt for CABP5: NX_Q9NP86

CABP5 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_062829.1  
ENSEMBL proteins: 
 ENSP00000293255  

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005737cytoplasm IDA--
GO:0005829cytosol IDA19338761
GO:0015630microtubule cytoskeleton IDA--


CABP5 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CABP5 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR018247 EF_Hand_1_Ca_BS
 IPR011992 EF-hand-like_dom
 IPR002048 EF_hand_Ca-bd
 IPR018248 EF-hand

Graphical View of Domain Structure for InterPro Entry Q9NP86

ProtoNet protein and cluster: Q9NP86

UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86
Similarity: Contains 4 EF-hand domains


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86
Function: Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation
to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity)

miRNA
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding NAS10625670


CABP5 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for CABP5:
 Increased gamma-H2AX phosphory 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Visual Cycle in Retinal Rods
Visual Cycle in Retinal Rods1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CABP5
    Visual Cycle in Retinal Rods


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CABP5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CABP5 (Q9NP863 ENSP000002932554) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PPP3R1P630983, ENSP000002343104I2D: score=1 STRING: ENSP00000234310
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction NAS10625670


CABP5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CABP5 gene (2 alternative transcripts): 
NM_019855.4  NM_016367.1  

Unigene Cluster for CABP5:

Calcium binding protein 5
Hs.117694  [show with all ESTs]
Unigene Representative Sequence: NM_019855
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000293255(uc002phu.2)

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hsa-miR-125a-5p hsa-miR-125b hsa-miR-2115 hsa-miR-33b hsa-miR-33a hsa-miR-4319
SwitchGear 3'UTR luciferase reporter plasmidCABP5 3' UTR sequence
Inhib. RNA
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Clone
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP5

Additional cDNA sequence: 

AF169159.1 BC126133.1 BC126135.1 

2 DOTS entries:

DT.40308759  DT.97835383 

16 AceView cDNA sequences:

BM709662 BQ640522 BQ639616 BQ185108 AF169159 H30054 BQ637976 BM709648 
BU734154 NM_019855 BX490518 BM709781 BM675997 AA318398 H30055 AF169158 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CABP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACAAAACC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

CABP5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
7 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType2 Off Cone Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType3a Off Cone Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType3b Off Cone Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType4 Off Cone Bipolar CellsBipolar, Retina
EyeInner Nuclear LayerType5 On Cone Bipolar CellsBipolar, Retina
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See CABP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CABP5

SOURCE GeneReport for Unigene cluster: Hs.117694

UniProtKB/Swiss-Prot: CABP5_HUMAN, Q9NP86
Tissue specificity: Retina

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CABP5 gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia CABP56
--
87(a)
1 ↔ 1
GL343287.1(684787-697907)
zebrafish
(Danio rerio)
Actinopterygii BC059438.12   -- 78.82(n)   393671  BC059438.1 
fruit fly
(Drosophila melanogaster)
Insecta CG135266
--
25(a)
1 → many
2R(18642745-18643401)


ENSEMBL Gene Tree for CABP5 (if available)
TreeFam Gene Tree for CABP5 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CABP5 gene
CALML32  CABP12  TNNC12  CALM32  CABP42  CABP22  CALM12  TNNC22  
CALML62  CALML52  CALML42  CABP72  CALN12  CALM22  
18/22 SIMAP similar genes for CABP5 using alignment to 1 protein entry:     CABP5_HUMAN(see all similar genes):
CABP1    CABP2    CABP4    CALM3    CALML3    CALM1
CALM2    CALN1    MYL6    CETN1    CETN2    TNNC1
TNNC2    CETN3    CALML5    MYL9    CABP7    MRLC3

CABP5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/430 NCBI SNPs in CABP5 are shown (see all 430    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2015507971,2
--48532145(+) GAGAT-/CACA  
  CCACTG
CACTC
1 -- ds50010--------
rs1390494561,2
--48532240(+) CACTTC/TGGGAG 1 -- ds50010--------
rs1156881581,2
F,--48532338(+) TTAGCT/CAGGCA 1 -- ds50011Minor allele frequency- C:0.09WA 118
rs1842716911,2
--48532362(+) GTGCAC/TGCCTG 1 -- ds50010--------
rs1161740491,2
F,--48532394(+) CTGAGG/ACGTAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1135985261,2
C,F,--48532439(+) GAGCCG/AAATTC 1 -- ds50011Minor allele frequency- A:0.03NA 120
rs1418118731,2
--48532446(+) ATTCGC/TGCCAC 1 -- ds50010--------
rs793979431,2
F,--48532512(+) TGCATG/ACATAC 1 -- ds50011Minor allele frequency- A:0.09WA 118
rs1471144491,2
--48532674(+) TTTAAC/TCTTTG 1 -- ut310--------
rs1481790921,2
--48532797(+) GAGACA/GCAGCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for CABP5 (48533210 - 48547304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CABP5
     3 CNVs: 47965 5105 32261
     2 Indels: 73396 102857

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CABP5 for disorders           About GeneDecksing

OMIM gene information: 607315    OMIM disorders: --

2 diseases for CABP5:    About MalaCards
neuronitis    retinitis

1 disease from the University of Copenhagen DISEASES database for CABP5:
Amebiasis

Export disorders for CABP5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CABP5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CABP5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670)1, 2, 3 Haeseleer F....Palczewski K. (2000)
  2. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PubMed id 19338761)1, 2 McCue H.V.... Haynes L.P. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease. (PubMed id 11108966)1, 2 Sokal I....Palczewski K. (2000)
  5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (PubMed id 11785943)1 Haeseleer F....Palczewski K. (2002)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
  9. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 56344 HGNC: 13714 AceView: CABP5 Ensembl:ENSG00000105507 euGenes: HUgn56344
ECgene: CABP5 H-InvDB: CABP5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CABP5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CABP5 gene:
Search GeneIP for patents involving CABP5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 Browse OriGene Antibodies   OriGene shRNA RFP for CABP5  
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABP5
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABP5
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP5
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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VWF
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von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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