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Aliases for CABP5 Gene

Aliases for CABP5 Gene

  • Calcium Binding Protein 5 2 3
  • CABP3 3 4
  • Calcium Binding Protein 3 2
  • Calcium-Binding Protein 3 3
  • Calcium-Binding Protein 5 3
  • CaBP5 4

External Ids for CABP5 Gene

Previous HGNC Symbols for CABP5 Gene

  • CABP3

Previous GeneCards Identifiers for CABP5 Gene

  • GC19M049177
  • GC19M048901
  • GC19M053209
  • GC19M053226
  • GC19M053228
  • GC19M053229
  • GC19M048533
  • GC19M044915

Summaries for CABP5 Gene

Entrez Gene Summary for CABP5 Gene

  • The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]

GeneCards Summary for CABP5 Gene

CABP5 (Calcium Binding Protein 5) is a Protein Coding gene. Diseases associated with CABP5 include amebiasis. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CABP5 Gene

  • Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABP5 Gene

Genomics for CABP5 Gene

Regulatory Elements for CABP5 Gene

Genomic Location for CABP5 Gene

48,029,383 bp from pter
48,044,054 bp from pter
14,672 bases
Minus strand

Genomic View for CABP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CABP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABP5 Gene

Proteins for CABP5 Gene

  • Protein details for CABP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • A0AUY4

    Protein attributes for CABP5 Gene

    173 amino acids
    Molecular mass:
    19826 Da
    Quaternary structure:
    • Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.

neXtProt entry for CABP5 Gene

Proteomics data for CABP5 Gene at MOPED

Post-translational modifications for CABP5 Gene

No Post-translational modifications

Other Protein References for CABP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CABP5 Gene

Domains for CABP5 Gene

Gene Families for CABP5 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for CABP5 Gene

Suggested Antigen Peptide Sequences for CABP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NP86
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with CABP5: view

Function for CABP5 Gene

Molecular function for CABP5 Gene

UniProtKB/Swiss-Prot Function: Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).

Gene Ontology (GO) - Molecular Function for CABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10625670
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CABP5: view

Phenotypes for CABP5 Gene

GenomeRNAi human phenotypes for CABP5:
genes like me logo Genes that share phenotypes with CABP5: view

Animal Model Products

CRISPR Products

miRNA for CABP5 Gene

miRTarBase miRNAs that target CABP5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CABP5 Gene

Localization for CABP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABP5 Gene


Subcellular locations from

Jensen Localization Image for CABP5 Gene COMPARTMENTS Subcellular localization image for CABP5 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 19338761
genes like me logo Genes that share ontologies with CABP5: view

Pathways for CABP5 Gene

SuperPathways for CABP5 Gene

genes like me logo Genes that share pathways with CABP5: view

Pathways by source for CABP5 Gene

1 Qiagen pathway for CABP5 Gene

Gene Ontology (GO) - Biological Process for CABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10625670
genes like me logo Genes that share ontologies with CABP5: view

Transcripts for CABP5 Gene

mRNA/cDNA for CABP5 Gene

(16) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABP5 Gene

Calcium binding protein 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABP5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CABP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABP5 Gene

No ASD Table

Relevant External Links for CABP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CABP5 Gene

mRNA expression in normal human tissues for CABP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABP5 Gene

This gene is overexpressed in Whole Blood (37.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CABP5 Gene

SOURCE GeneReport for Unigene cluster for CABP5 Gene Hs.117694

mRNA Expression by UniProt/SwissProt for CABP5 Gene

Tissue specificity: Retina.
genes like me logo Genes that share expressions with CABP5: view

In Situ Assay Products

Orthologs for CABP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CABP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CABP5 35
  • 99.13 (n)
  • 98.69 (a)
CABP5 36
  • 99 (a)
(Bos Taurus)
Mammalia CABP5 35
  • 89.4 (n)
  • 94.8 (a)
CABP5 36
  • 95 (a)
(Canis familiaris)
Mammalia CABP5 35
  • 90.94 (n)
  • 96.53 (a)
CABP5 36
  • 97 (a)
(Mus musculus)
Mammalia Cabp5 35
  • 88.63 (n)
  • 93.06 (a)
Cabp5 16
Cabp5 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CABP5 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Cabp5 35
  • 89.02 (n)
  • 94.22 (a)
(Anolis carolinensis)
Reptilia CABP5 36
  • 88 (a)
(Danio rerio)
Actinopterygii -- 35
cabp5a 35
  • 72.22 (n)
  • 79.01 (a)
cabp5a 36
  • 77 (a)
cabp5b 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11638 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea cal-8 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for CABP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CABP5 Gene

Gene Tree for CABP5 (if available)
Gene Tree for CABP5 (if available)

Paralogs for CABP5 Gene

Selected SIMAP similar genes for CABP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CABP5: view

Variants for CABP5 Gene

Sequence variations from dbSNP and Humsavar for CABP5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs750455 -- 48,039,075(-) GGATC(A/G)ATAAA intron-variant
rs750456 -- 48,039,052(-) ATAAC(A/G)TATTC intron-variant
rs750457 -- 48,038,963(-) AACAC(A/G)CACAC intron-variant
rs875765 -- 48,038,467(+) TACCA(G/T)ATGAC intron-variant
rs891015 -- 48,039,157(-) TCTGA(G/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABP5 Gene

Variant ID Type Subtype PubMed ID
nsv428367 CNV Gain+Loss 18775914
nsv9739 CNV Gain+Loss 18304495
nsv833853 CNV Loss 17160897
nsv912216 CNV Loss 21882294
esv34181 CNV Loss 18971310
esv25290 CNV Loss 19812545
esv2619667 CNV Insertion 19546169

Relevant External Links for CABP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABP5 Gene

Disorders for CABP5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CABP5 Gene including...

Search for CABP5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CABP5 Gene

genes like me logo Genes that share disorders with CABP5: view

No data available for UniProtKB/Swiss-Prot for CABP5 Gene

Publications for CABP5 Gene

  1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PMID: 10625670) Haeseleer F. … Palczewski K. (J. Biol. Chem. 2000) 2 3 4
  2. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease. (PMID: 11108966) Sokal I. … Palczewski K. (Biochim. Biophys. Acta 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PMID: 19338761) McCue H.V. … Haynes L.P. (Biochem. Biophys. Res. Commun. 2009) 3 4
  5. Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum. (PMID: 24599957) Di Jeso B. … Arvan P. (J. Biol. Chem. 2014) 3

Products for CABP5 Gene

Sources for CABP5 Gene

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