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CABP4 Gene

protein-coding   GIFtS: 52
GCID: GC11P067222

Calcium Binding Protein 4

  See CABP4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding Protein 41 2
CSNB2B2 5
Calcium-Binding Protein 42
CaBP43

External Ids:    HGNC: 13861   Entrez Gene: 570102   Ensembl: ENSG000001755447   OMIM: 6089655   UniProtKB: P577963   

Export aliases for CABP4 gene to outside databases

Previous GC identifers: GC11M069718 GC11P068916 GC11P067469 GC11P066995 GC11P066998 GC11P066976 GC11P063553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CABP4 Gene:
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs.
Mutations in this gene are associated with congenital stationary night blindness type 2B. (provided by RefSeq,
Mar 2010)

GeneCards Summary for CABP4 Gene:
CABP4 (calcium binding protein 4) is a protein-coding gene. Diseases associated with CABP4 include congenital stationary night blindness, type 2b, and night blindness, congenital stationary , 2b, autosomal recessive. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CABP4_HUMAN, P57796
Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in
photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the
calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CABP4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Bach2   Nkx2-5   CUTL1   E2F-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCABP4 promoter sequence
   Search Chromatin IP Primers for CABP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CABP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

CABP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABP4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067222:  view genomic region     (about GC identifiers)

Start:
67,219,877 bp from pter      End:
67,229,245 bp from pter
Size:
9,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CABP4_HUMAN, P57796 (See protein sequence)
Recommended Name: Calcium-binding protein 4  
Size: 275 amino acids; 30433 Da
Subunit: Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner (By similarity).
Interacts (via N-terminus) with UNC119 (By similarity)
Secondary accessions: Q8N4Z2 Q8WWY5
Alternative splicing: 2 isoforms:  P57796-1   P57796-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CABP4: NX_P57796

Explore proteomics data for CABP4 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CABP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660201.1  
    ENSEMBL proteins: 
     ENSP00000401555   ENSP00000324960   ENSP00000439145  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR015754 Ca_binding_pro
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P57796

    ProtoNet protein and cluster: P57796

    UniProtKB/Swiss-Prot: CABP4_HUMAN, P57796
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CABP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CABP4_HUMAN, P57796
    Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in
    photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the
    calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS15452577
         
    Find genes that share ontologies with CABP4           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cabp4):
     nervous system  vision/eye 

    Find genes that share phenotypes with CABP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cabp4tm1Kpal for CABP4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CABP4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CABP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CABP4

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    hsa-miR-511 hsa-miR-1178 hsa-miR-185 hsa-miR-1236 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidCABP4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CABP4_HUMAN, P57796: Cytoplasm. Note=Found in rod spherules and cone pedicles of the presynapses from both types
    of photoreceptors (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS16960802
    GO:0005829cytosol IDA19338761
    GO:0043195terminal bouton TAS15452577
    GO:0045202synapse TAS16960802

    Find genes that share ontologies with CABP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CABP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CABP4
        Visual Cycle in Retinal Rods


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CABP4
    Interactions:

        GeneGlobe Interaction Network for CABP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CABP4 (P577963 ENSP000003249604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1FO608403, ENSP000003654414I2D: score=2 STRING: ENSP00000365441
    CACNA1CENSP000002663764STRING: ENSP00000266376
    PI4KBENSP000002716574STRING: ENSP00000271657
    MYO1EENSP000002882354STRING: ENSP00000288235
    MYO1FENSP000003448714STRING: ENSP00000344871
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS10625670
    GO:0007601visual perception IMP16960802
    GO:0007602phototransduction IEA--
    GO:0008594photoreceptor cell morphogenesis IEA--
    GO:0046549retinal cone cell development IEA--

    Find genes that share ontologies with CABP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CABP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CABP4 gene: 
    NM_145200.3  

    Unigene Cluster for CABP4:

    Calcium binding protein 4
    Hs.143036  [show with all ESTs]
    Unigene Representative Sequence: NM_145200
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538060 ENST00000438189(uc001oln.3) ENST00000542025 ENST00000545040(uc009yrw.1)
    ENST00000542233 ENST00000325656(uc001olo.3) ENST00000545777
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate CABP4:
    hsa-miR-511 hsa-miR-1178 hsa-miR-185 hsa-miR-1236 hsa-miR-4306
    SwitchGear 3'UTR luciferase reporter plasmidCABP4 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for CABP4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CABP4
      QuantiTect SYBR Green Assays in human, mouse, rat CABP4
      QuantiFast Probe-based Assays in human, mouse, rat CABP4

    Additional mRNA sequence: 

    AY039217.1 BC033167.1 

    8 DOTS entries:

    DT.40298535  DT.91987576  DT.97837996  DT.120720087  DT.91928432  DT.120710910  DT.99981319  DT.40285777 

    19 AceView cDNA sequences:

    AI569060 BC033167 NM_145200 BX115851 AY039217 CR615565 BM690981 BX510148 
    BX283598 BI766814 BQ882349 BG330956 BX954839 BX422498 BU726309 AI129455 
    AL712439 H70963 H69788 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CABP4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
    SP1:                                                      
    SP2:                          -                           


    ECgene alternative splicing isoforms for CABP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CABP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAATGGAG
    CABP4 Expression
    About this image


    CABP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    CABP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CABP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143036

    UniProtKB/Swiss-Prot: CABP4_HUMAN, P57796
    Tissue specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CABP4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cabp41 , 5 calcium binding protein 41, 5 80.44(n)1
    77.99(a)1
      19 (3.84 cM)5
    736601  NM_144532.21  NP_653115.11 
     41354255 
    chicken
    (Gallus gallus)
    Aves CABP41 calcium-binding protein 4 66.82(n)
    64.29(a)
      100857896  XM_003641279.2  XP_003641327.1 
    lizard
    (Anolis carolinensis)
    Reptilia CABP46
    calcium binding protein 4
    58(a)
    1 ↔ 1
    1(93363954-93379594)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC1474501 uncharacterized protein MGC147450 54.47(n)
    48.97(a)
      780009  NM_001079086.1  NP_001072554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cabp41 calcium binding protein 4 56.86(n)
    52.94(a)
      797905  XM_001338325.3  XP_001338361.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116386
    --
    21(a)
    1 → many
    X(908017-920736)
    worm
    (Caenorhabditis elegans)
    Secernentea cal-86
    Protein CAL-8 (cal-8) mRNA, complete cds
    31(a)
    1 → many
    II(5480591-5482043) WBGene00017394


    ENSEMBL Gene Tree for CABP4 (if available)
    TreeFam Gene Tree for CABP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CABP4 gene
    CALML32  CABP52  CABP12  TNNC12  CALM32  CABP22  CALM12  CALML62  
    TNNC22  CALML52  CALML42  CALM22  
    11 SIMAP similar genes for CABP4 using alignment to 2 protein entries:     CABP4_HUMAN (see all proteins):
    CABP5    CABP1    CABP2    CALM1    CALM3    CALM2
    CALML3    CETN1    TNNC2    MYL6    CALML6

    Find genes that share paralogs with CABP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CABP4 (see all 246)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178281,2,,4
    C,FNight blindness, congenital stationary, 2B (CSNB2B)4 pathogenic167143278(+) AGGACC/TGCGAA 2 R C mis11Minor allele frequency- T:0.00NA 4540
    rs79368001,2
    C,F,H--67140479(+) TAAGTA/GAAGTA 1 -- us2k116Minor allele frequency- G:0.09NS EA NA 1802
    rs1431552641,2
    C--67140535(+) TGGGAA/GGATCA 1 -- us2k10--------
    rs1903887721,2
    --67140894(+) CAAGGC/TCCCTT 1 -- us2k10--------
    rs1812513051,2
    --67140958(+) TGGTTC/TCCATG 1 -- us2k10--------
    rs1864943031,2
    --67140987(+) GTAGGA/GAGTCT 1 -- us2k10--------
    rs1913363911,2
    --67141135(+) CCCACC/TGCGGC 1 -- us2k10--------
    rs1827576741,2
    C--67141202(+) TGCTAA/TAGAGA 1 -- us2k10--------
    rs1152045871,2
    C,F--67141317(+) TTCCCC/TGCTGG 1 -- us2k12Minor allele frequency- T:0.05WA EA 238
    rs16385611,2
    C,F,A,H--67141326(+) GGCAGC/AGGGGA 1 -- us2k16Minor allele frequency- A:0.15NS EA WA 418

    HapMap Linkage Disequilibrium report for CABP4 (67219877 - 67229245 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CABP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468604CNV Loss19166990
    nsv527056CNV Loss19592680
    nsv524096CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897801CNV Loss21882294
    nsv528976CNV Loss19592680
    nsv897804CNV Gain21882294

    Human Gene Mutation Database (HGMD): CABP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CABP4
    DNA2.0 Custom Variant and Variant Library Synthesis for CABP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608965   
    OMIM disorders: 610427  
    UniProtKB/Swiss-Prot: CABP4_HUMAN, P57796
  • Night blindness, congenital stationary, 2B (CSNB2B) [MIM:610427]: A non-progressive retinal disorder
    characterized by impaired night vision, often associated with nystagmus and myopia. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 7 diseases for CABP4:    
    About MalaCards
    congenital stationary night blindness, type 2b    night blindness, congenital stationary , 2b, autosomal recessive    retinal disease    congenital nystagmus
    night blindness    night blindness, congenital stationary , 1d, autosomal recessive    blindness

    2 diseases from the University of Copenhagen DISEASES database for CABP4:
    Night blindness     Congenital nystagmus

    Find genes that share disorders with CABP4           About GenesLikeMe

    Genetic Association Database (GAD): CABP4
    Human Genome Epidemiology (HuGE) Navigator: CABP4 (2 documents)

    Export disorders for CABP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CABP4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CABP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. (PubMed id 16960802)1, 2, 3 Zeitz C.... Berger W. (Am. J. Hum. Genet. 2006)
    2. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670)1, 2, 3 Haeseleer F.... Palczewski K. (J. Biol. Chem. 2000)
    3. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    4. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. (PubMed id 19338761)1, 2 McCue H.V.... Haynes L.P. (Biochem. Biophys. Res. Commun. 2009)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. (PubMed id 15452577)1, 2 Haeseleer F.... Palczewski K. (Nat. Neurosci. 2004)
    8. A null mutation in CABP4 causes Leber's congenital amaurosis-like phenotype. (PubMed id 20157620)1, 9 Aldahmesh M.A....Alkuraya F.S. (Mol. Vis. 2010)
    9. Genotype and phenotype of 101 dutch patients with congenital stationary night blindness. (PubMed id 23714322)1 Bijveld M.M....van Genderen M.M. (Ophthalmology 2013)
    10. Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4). (PubMed id 22936811)1 Shaltiel L....Wahl-Schott C.A. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57010 HGNC: 1386 AceView: CABP4 Ensembl:ENSG00000175544 euGenes: HUgn57010
    ECgene: CABP4 H-InvDB: CABP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CABP4 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CABP4[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CABP4 gene:
    Search GeneIP for patents involving CABP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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