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CABP1 Gene

protein-coding   GIFtS: 49
GCID: GC12P121078

Calcium Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding Protein 11 2     Calcium Binding Protein 52
caldendrin1 2     Calcium-Binding Protein 12
calbrain1     CaBP13
CALBRAIN2     Calbrain3
HCALB_BR2     Caldendrin3

External Ids:    HGNC: 13841   Entrez Gene: 94782   Ensembl: ENSG000001577827   OMIM: 6055635   UniProtKB: Q9NZU73   

Export aliases for CABP1 gene to outside databases

Previous GC identifers: GC12M120133 GC12P120676 GC12P120861 GC12P119490 GC12P119541 GC12P118087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CABP1 Gene:
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene
encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin.
The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein
inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing
voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity
of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor
potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results
in multiple transcript variants encoding disinct isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for CABP1 Gene:
CABP1 (calcium binding protein 1) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation
of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CABP1 gene promoter:
         Tal-1   HSF1 (long)   AP-4   Nkx2-5   Tal-1beta   E47   HSF1short   ITF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCABP1 promoter sequence
   Search Chromatin IP Primers for CABP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CABP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

CABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P121078:  view genomic region     (about GC identifiers)

Start:
121,078,355 bp from pter      End:
121,105,127 bp from pter
Size:
26,773 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7 (See protein sequence)
Recommended Name: Calcium-binding protein 1  
Size: 370 amino acids; 39838 Da
Subunit: Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3.
This binding is calcium dependent and the interaction correlates with calcium concentration. An additional
calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the
receptor. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts
with CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the
binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with
CACNA1D (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules
with MAP1LC3B. Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central
NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor
stimulation and prevents nuclear import of NSMF (By similarity)
Caution: The interaction with CACNA1A is described as calcium independent in PubMed:11865310 while it is shown to
be acutely calcium dependent in PubMed:14570872. PubMed:12032348 describes a stimulatory effect of CABP1 during
agonist-induced intracellular calcium signaling while PubMed:14570872 and PubMed:11865310 show an inhibitory
effect
Selected PDB 3D structures from and Proteopedia for CABP1 (see all 7):
2K7B (3D)        2K7C (3D)        2K7D (3D)        2LAN (3D)        2LAP (3D)        3OX5 (3D)    
Secondary accessions: O95663 Q8N6H5 Q9NZU8
Alternative splicing: 4 isoforms:  Q9NZU7-4   Q9NZU7-1   Q9NZU7-2   Q9NZU7-3   (It is currently uncertain whether calbrain represent a spliced isoform)

Explore the universe of human proteins at neXtProt for CABP1: NX_Q9NZU7

Explore proteomics data for CABP1 at MOPED

Post-translational modifications: 

  • Phosphorylated. The phosphorylation regulates the activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CABP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028849.1  NP_004267.2  NP_112482.1  

    ENSEMBL proteins: 
     ENSP00000317310   ENSP00000288616   ENSP00000288615   ENSP00000398959  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR015754 Ca_binding_pro
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9NZU7

    ProtoNet protein and cluster: Q9NZU7

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Domain: EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium
    cooperatively and EF-2 binds neither calcium nor magnesium
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CABP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CABP1_HUMAN, Q9NZU7
    Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
    agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
    facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
    inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
    CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation
    of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS9920909
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11865310
    GO:0008139nuclear localization sequence binding ISS--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with CABP1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cabp1 (no phenotypes)

    Find genes that share phenotypes with CABP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CABP1

    miRNA
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    hsa-mir-124-3p (MIRT022186), hsa-mir-335-5p (MIRT016957)

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    Selected qRT-PCR Assays for microRNAs that regulate CABP1 (see all 15):
    hsa-miR-4254 hsa-miR-1914* hsa-miR-566 hsa-miR-513a-5p hsa-miR-27a hsa-miR-658 hsa-miR-1271 hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidCABP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CABP1_HUMAN, Q9NZU7: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor;
    Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
    Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near
    the plasma membrane
    CABP1_HUMAN, Q9NZU7: Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the
    cytoskeletal structures
    CABP1_HUMAN, Q9NZU7: Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor (Probable).
    Note=S-CaBP1 is localized at or near the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    cytosol3
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA19338761
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with CABP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CABP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CABP1
        Visual Cycle in Retinal Rods


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CABP1
    Interactions:

        GeneGlobe Interaction Network for CABP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CABP1 (Q9NZU71, 3 ENSP000003173104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 3, ENSP000002663764EBI-907894,EBI-1038838 I2D: score=4 STRING: ENSP00000266376
    CACNA1AO005553, ENSP000003533624I2D: score=1 STRING: ENSP00000353362
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    NMT1P304193, ENSP000002589604I2D: score=1 STRING: ENSP00000258960
    ITPR1Q146433, ENSP000004059344I2D: score=1 STRING: ENSP00000405934
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010651negative regulation of cell communication by electrical coupling IEA--
    GO:0042308negative regulation of protein import into nucleus ISS--
    GO:0043086negative regulation of catalytic activity TAS9920909
    GO:1901385regulation of voltage-gated calcium channel activity ----
    GO:1901386negative regulation of voltage-gated calcium channel activity IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for CABP1

    2 Novoseek inferred chemical compound relationships for CABP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,4,5 trisphosphate 41.9 2 19008222 (3), 19636832 (1), 19636926 (1)
    calcium 36.5 25 11865310 (4), 17224447 (3), 16049183 (3), 14570872 (1) (see all 8)



    Find genes that share compounds with CABP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CABP1 gene (3 alternative transcripts): 
    NM_001033677.1  NM_004276.4  NM_031205.3  

    Unigene Cluster for CABP1:

    Calcium binding protein 1
    Hs.458482  [show with all ESTs]
    Unigene Representative Sequence: BC030201
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316803(uc001tyu.3) ENST00000288616 ENST00000351200 ENST00000453000(uc001tyv.3 uc001tyw.3 uc001tyx.3)
    ENST00000498082
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    Additional mRNA sequence: 

    AF169148.1 AF169149.1 BC030201.1 

    9 DOTS entries:

    DT.95265177  DT.100020539  DT.100646967  DT.92425494  DT.40207821  DT.444129  DT.92425497  DT.100646972 
    DT.91723595 

    Selected AceView cDNA sequences (see all 63):

    BC030201 CR612944 BM702046 NM_031205 BM716422 BM666634 BM696690 BQ188503 
    NM_004276 CR602468 CR619895 BU735205 AA363865 AL565119 AF169149 CK300230 
    AI096715 AF169148 AL537015 BM685205 BC015006 BM701038 BI754074 CB046141 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CABP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGCCCCAG
    CABP1 Expression
    About this image


    CABP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Pons
     
     Dermis (Integumentary System)
    CABP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CABP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458482

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Tissue specificity: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in
    brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CABP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cabp15 calcium binding protein 1   --   5 (55.99 cM) 115168689 
    chicken
    (Gallus gallus)
    Aves CABP16
    calcium binding protein 1
    55(a)
    1 ↔ 1
    15(9206727-9233056)
    lizard
    (Anolis carolinensis)
    Reptilia CABP16
    calcium binding protein 1
    77(a)
    1 ↔ 1
    GL343338.1(154659-161881)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW159042.12   -- 80.25(n)    AW159042.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cabp1a1 calcium binding protein 1a 77.41(n)
    87.5(a)
      449789  NM_001005962.1  NP_001005962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116386
    --
    20(a)
    1 → many
    X(908017-920736)
    worm
    (Caenorhabditis elegans)
    Secernentea cal-86
    Protein CAL-8 (cal-8) mRNA, complete cds
    32(a)
    1 → many
    II(5480591-5482043) WBGene00017394


    ENSEMBL Gene Tree for CABP1 (if available)
    TreeFam Gene Tree for CABP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CABP1 gene
    CALML32  CABP52  TNNC12  CALM32  CABP42  CABP22  CALM12  CALML62  
    TNNC22  CALML52  CALML42  CALM22  
    18 SIMAP similar genes for CABP1 using alignment to 2 protein entries:     CABP1_HUMAN (see all proteins):
    CABP5    CABP2    CABP4    CALM1    CALM2    CALML3
    CALN1    CALM3    CABP7    MYL1    CALML5    CETN1
    MYL6    TNNC1    CETN2    TNNC2    CETN3    CALML6

    Find genes that share paralogs with CABP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CABP1 (see all 634)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573245731,2
    C--118094755(+) TTTTT-/T/T   
       TTTTT
    GAGAT
    2 -- int1 cds11NA 2
    rs2002015441,2
    C--118102973(+) TGCGT-/GCGTGTG 3 -- int10--------
    rs286697631,2
    C,F--118102974(+) GCGTGT/CGTGTG 3 -- int13Minor allele frequency- C:0.33WA NA 6
    rs1407297331,2
    --120869913(+) ATTGAC/TTGACC 1 -- us2k10--------
    rs1891988911,2
    --120869920(+) GACCTC/TGAACT 1 -- us2k10--------
    rs1930604421,2
    --120870173(+) ATAAGC/TAAAAG 1 -- us2k10--------
    rs1384711871,2
    --120870182(+) AGAGGA/CACACA 1 -- us2k10--------
    rs1832638681,2
    --120870196(+) CCCAGC/TGCGGT 1 -- us2k10--------
    rs1875393891,2
    --120870197(+) CCAGCA/GCGGTG 1 -- us2k10--------
    rs1919664661,2
    --120870199(+) AGCGCA/GGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CABP1 (121078355 - 121105127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CABP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899557CNV Loss21882294
    nsv521928CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CABP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605563    OMIM disorders: --


    Find genes that share disorders with CABP1           About GenesLikeMe


    Export disorders for CABP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CABP1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with CABP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670)1, 2, 3 Haeseleer F.... Palczewski K. (J. Biol. Chem. 2000)
    2. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. (PubMed id 9920909)1, 2, 3 Yamaguchi K....Hatase O. (J. Biol. Chem. 1999)
    3. Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. (PubMed id 15980432)1, 2, 9 Zhou H.... Lee A. (J. Biol. Chem. 2005)
    4. Structural insights into Ca2+-dependent regulation of inositol 1,4,5- trisphosphate receptors by CaBP1. (PubMed id 19008222)1, 2, 9 Li C....Ames J.B. (J. Biol. Chem. 2009)
    5. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+- binding protein 1. (PubMed id 11865310)1, 2, 9 Lee A....Catterall W.A. (Nat. Neurosci. 2002)
    6. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. (PubMed id 14570872)1, 2, 9 Haynes L.P.... Burgoyne R.D. (J. Biol. Chem. 2004)
    7. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron- specific regulator of calcium channels. (PubMed id 16147998)1, 2 Wingard J.N.... Ames J.B. (J. Biol. Chem. 2005)
    8. Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. (PubMed id 14685260)1, 2 Kasri N.N.... Roderick H.L. (EMBO J. 2004)
    9. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. (PubMed id 15140941)1, 2 Zhou H....Lee A. (J. Neurosci. 2004)
    10. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. (PubMed id 12032348)1, 2 Yang J.... Foskett J.K. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9478 HGNC: 1384 AceView: CABP1 Ensembl:ENSG00000157782 euGenes: HUgn9478
    ECgene: CABP1 H-InvDB: CABP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CABP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CABP1 gene:
    Search GeneIP for patents involving CABP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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