Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CABP1 Gene

protein-coding   GIFtS: 49
GCID: GC12P121078

calcium binding protein 1
 Explore 6 diseases affiliated with
CABP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CABP1    

Aliases
for CABP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium Binding Protein 11 2     Caldendrin3
CALBRAIN2     CaBP13
HCALB_BR2     Calbrain3
Calcium Binding Protein 52     Caldendrin3
Calcium-Binding Protein 12     

External Ids:    HGNC: 13841   Entrez Gene: 94782   Ensembl: ENSG000001577827   OMIM: 6055635   UniProtKB: Q9NZU73   

Export aliases for CABP1 gene to outside databases

Previous GC identifers: GC12M120133 GC12P120676 GC12P120861 GC12P119490 GC12P119541 GC12P118087


Summaries
for CABP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CABP1:
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes
a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein
encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits
calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing
voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of
inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential
channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple
transcript variants encoding disinct isoforms. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of
CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity)




Genomic Views
for CABP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CABP1 gene promoter:
         Tal-1   HSF1 (long)   AP-4   Nkx2-5   Tal-1beta   E47   HSF1short   ITF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CABP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CABP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

CABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P121078:  view genomic region     (about GC identifiers)

Start:
 121,078,355 bp from pter      End:
 121,105,127 bp from pter
Size:
 26,773 bases      Orientation:
 plus strand

Proteins
for CABP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7 (See protein sequence)
Recommended Name: Calcium-binding protein 1  
Size: 370 amino acids; 39838 Da
Subunit: Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This
binding is calcium dependent and the interaction correlates with calcium concentration. An additional
calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the receptor.
Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts with CACNA1C (via
C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the binding to IQ requires the
presence of calcium and is mutually exclusive with calmodulin binding. Interacts with CACNA1D (By similarity).
Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B. Interacts with
MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the
interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import
of NSMF (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic
side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is
associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane
Subcellular location: Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the
cytoskeletal structures
Subcellular location: Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor (Probable). Note=S-CaBP1 is
localized at or near the plasma membrane
Caution: The interaction with CACNA1A is described as calcium independent in PubMed:11865310 while it is shown to be
acutely calcium dependent in PubMed:14570872. PubMed:12032348 describes a stimulatory effect of CABP1 during
agonist-induced intracellular calcium signaling while PubMed:14570872 and PubMed:11865310 show an inhibitory effect
6/7 PDB 3D structures from and Proteopedia for CABP1 (see all 7):
2K7B (3D)        2K7C (3D)        2K7D (3D)        2LAN (3D)        2LAP (3D)        3OX5 (3D)    
Secondary accessions: O95663 Q8N6H5 Q9NZU8
Alternative splicing: 4 isoforms:  Q9NZU7-4   Q9NZU7-1   Q9NZU7-2   Q9NZU7-3   (It is currently uncertain whether calbrain represent a spliced isoform)

Explore the universe of human proteins at neXtProt for CABP1: NX_Q9NZU7

Post-translational modifications:

  • Phosphorylated. The phosphorylation regulates the activity1
  • View modification sites using PhosphoSitePlus2 (CABP1)
  • View neXtProt modification sites for NX_Q9NZU7

    • CABP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028849.1  NP_004267.2  NP_112482.1  

    ENSEMBL proteins: 
     ENSP00000317310   ENSP00000288616   ENSP00000288615   ENSP00000398959  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CABP1
    OriGene Protein Over-expression Lysate: CABP1
    OriGene Custom Protein Services for CABP1 
    GenScript Custom Purified and Recombinant Proteins Services for CABP1
    Novus Biologicals CABP1 Proteins
    Novus Biologicals CABP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CABP1

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA19338761
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IDA19338761


    CABP1 for ontologies           About GeneDecksing



    CABP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): CABP1
    OriGene Custom Antibody Services for CABP1 
    GenScript Custom Superior Antibodies Services for CABP1
    Novus Biologicals CABP1 Antibodies
    Abcam antibodies for CABP1 
    Uscn Antibodies for CABP1
    ThermoFisher Antibodies for CABP1

    Assay Products for CABP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CABP1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CABP1

    Protein Domains /
    Families
    for CABP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CABP1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand

    Graphical View of Domain Structure for InterPro Entry Q9NZU7

    ProtoNet protein and cluster: Q9NZU7

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Domain: EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively
    and EF-2 binds neither calcium nor magnesium
    Similarity: Contains 4 EF-hand domains


    Function
    for CABP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
    agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
    facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
    inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
    CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of
    CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): CABP1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CABP1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CABP1 (see all 15):
    hsa-miR-4254 hsa-miR-1914* hsa-miR-566 hsa-miR-513a-5p hsa-miR-27a hsa-miR-658 hsa-miR-1271 hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmid: CABP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABP1 (see all 7)
    OriGene shRNA RFP: CABP1
    OriGene siRNA: CABP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CABP1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CABP1 (NM_031205)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CABP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CABP1
    Search LifeMap BioReagents cell lines for CABP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS9920909
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15140941
    GO:0008139nuclear localization sequence binding ISS--
    GO:0048306calcium-dependent protein binding IPI15980432


    CABP1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CABP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Visual Cycle in Retinal Rods
    		Visual Cycle in Retinal Rods1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CABP1
        Visual Cycle in Retinal Rods


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CABP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for CABP1 (Q9NZU71, 3 ENSP000003173104) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 3, ENSP000002663764EBI-907894,EBI-1038838 I2D: score=4 STRING: ENSP00000266376
    CACNA1AO005553, ENSP000003533624I2D: score=1 STRING: ENSP00000353362
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    NMT1P304193, ENSP000002589604I2D: score=1 STRING: ENSP00000258960
    ITPR1Q146433, ENSP000004059344I2D: score=1 STRING: ENSP00000405934
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042308negative regulation of protein import into nucleus ISS--
    GO:0043086negative regulation of catalytic activity TAS9920909


    CABP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CABP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CABP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CABP1
    2 Novoseek chemical compound relationships for CABP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,4,5 trisphosphate 41.9 2 19008222 (3), 19636832 (1), 19636926 (1)
    calcium 36.5 25 11865310 (4), 17224447 (3), 16049183 (3), 14570872 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about CABP1 

    Transcripts
    for CABP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CABP1 gene (3 alternative transcripts): 
    NM_001033677.1  NM_004276.4  NM_031205.3  

    Unigene Cluster for CABP1:

    Calcium binding protein 1
    Hs.458482  [show with all ESTs]
    Unigene Representative Sequence: BC030201
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316803(uc001tyu.3) ENST00000288616 ENST00000351200 ENST00000453000(uc001tyv.3 uc001tyw.3 uc001tyx.3)
    ENST00000498082

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CABP1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CABP1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CABP1 (see all 15):
    hsa-miR-4254 hsa-miR-1914* hsa-miR-566 hsa-miR-513a-5p hsa-miR-27a hsa-miR-658 hsa-miR-1271 hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmid: CABP1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABP1 (see all 7)
    OriGene shRNA RFP: CABP1
    OriGene siRNA: CABP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABP1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CABP1 (NM_031205)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CABP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABP1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CABP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP1

    Additional cDNA sequence: 

    AF169148.1 AF169149.1 BC030201.1 

    9 DOTS entries:

    DT.95265177  DT.100020539  DT.100646967  DT.92425494  DT.40207821  DT.444129  DT.92425497  DT.100646972 
    DT.91723595 

    24/63 AceView cDNA sequences (see all 63):

    CR619895 NM_031205 NM_004276 BC030201 BM666634 BM696690 BU735205 BM716422 
    BQ188503 CR612944 CR602468 BM702046 BC015006 CB046141 BM685205 CK300230 
    AF169149 BM701038 AI096715 BI598798 AL533429 AA775253 AF169148 BM932210 

    GeneLoc Exon Structure


    Expression
    for CABP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CABP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCGCCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CABP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType2 Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3a Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3b Off Cone Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CABP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CABP1

    SOURCE GeneReport for Unigene cluster: Hs.458482

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Tissue specificity: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain
    where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum

        SABiosciences Custom PCR Arrays for CABP1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABP1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CABP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP1

    Orthologs
    for CABP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CABP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CABP16
    		 Uncharacterized protein
    		 84(a)
    		 1 ↔ 1
    		 15(9465959-9479340)
    lizard
    (Anolis carolinensis)    		 Reptilia CABP16
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343338.1(149493-161025)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AW159042.12   -- 80.25(n)    AW159042.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cabp1a1 calcium binding protein 1a 77.41(n)
    87.5(a)    		   449789  NM_001005962.1  NP_001005962.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG135266
    		 --
    		 28(a)
    		 1 → many
    		 2R(18642745-18643401)


    ENSEMBL Gene Tree for CABP1 (if available)
    TreeFam Gene Tree for CABP1 (if available) 

    Paralogs
    for CABP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CABP1 gene
    CALML32  CABP52  TNNC12  CALM32  CABP42  CABP22  CALM12  TNNC22  
    CALML62  CALML52  CALML42  CABP72  CALN12  CALM22  
    18/19 SIMAP similar genes for CABP1 using alignment to 2 protein entries:     CABP1_HUMAN (see all proteins) (see all similar genes):
    CABP5    CABP2    CABP4    CALM3    CALM1    CALML3
    CALN1    CALM2    CABP7    MYL1    CALML5    CETN1
    MYL2    MYL6    TNNC1    CETN2    TNNC2    CETN3

    CABP1 for paralogs           About GeneDecksing



    Genomic Variants
    for CABP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/512 NCBI SNPs in CABP1 are shown (see all 512)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs123159171,2
    		C,F,--118086535(+) catgcC/Ttacaa 1 -- us2k15Minor allele frequency- T:0.20WA NA 244
    rs752217481,2
    		F,--118086914(+) TGTCCG/CAGCAC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1125122891,2
    		--118087198(+) GTCCTC/ACCTGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs763139651,2
    		C,F,--118087244(+) CTCTTC/TTATTC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs794114021,2
    		--118087446(+) TTCTCC/TCCGGA 1 -- us2k10--------
    rs2005840591,2
    		C--118089101(-) ACCCCA/CAAGTT 1 -- int10--------
    rs64902991,2
    		C,F,A,--118089161(+) GCCACA/GAAGAG 1 -- int18Minor allele frequency- G:0.32WA NA EA 370
    rs800977441,2
    		C,F,--118089169(+) GAGGTC/TATCAG 1 -- int15Minor allele frequency- T:0.19WA NA 244
    rs73011501,2
    		A--118089443(+) AGAGCA/GTTTGC 1 -- int10--------
    rs732131061,2
    		C,--118089616(+) AGTGGC/GTGATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CABP1 (121078355 - 121105127 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CABP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CABP1

    Disorders / Diseases
    for CABP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CABP1 for disorders           About GeneDecksing

    OMIM gene information: 605563    OMIM disorders: --

    6 diseases for CABP1:    About MalaCards
    congenital stationary night blindness    night blindness    amebiasis    blindness
    neuronitis    retinitis


    Export disorders for CABP1 gene to outside databases

    Publications
    for CABP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CABP1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CABP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670)1, 2, 3 Haeseleer F....Palczewski K. (2000)
    2. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. (PubMed id 9920909)1, 2, 3 Yamaguchi K....Hatase O. (1999)
    3. Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. (PubMed id 15980432)1, 2, 9 Zhou H.... Lee A. (2005)
    4. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. (PubMed id 19008222)1, 2, 9 Li C....Ames J.B. (2009)
    5. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. (PubMed id 11865310)1, 2, 9 Lee A....Catterall W.A. (2002)
    6. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. (PubMed id 14570872)1, 2, 9 Haynes L.P....Burgoyne R.D. (2004)
    7. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron- specific regulator of calcium channels. (PubMed id 16147998)1, 2 Wingard J.N.... Ames J.B. (2005)
    8. Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. (PubMed id 14685260)1, 2 Kasri N.N.... Roderick H.L. (2004)
    9. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. (PubMed id 15140941)1, 2 Zhou H....Lee A. (2004)
    10. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. (PubMed id 12032348)1, 2 Yang J.... Foskett J.K. (2002)

    External Searches for CABP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CABP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9478 HGNC: 1384 AceView: CABP1 Ensembl:ENSG00000157782 euGenes: HUgn9478
    ECgene: CABP1 H-InvDB: CABP1

    Other Databases showing CABP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CABP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CABP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CABP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CABP1 gene:
    Search GeneIP for patents involving CABP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CABP1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CABP1   OriGene shRNA RFP for CABP1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABP1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABP1  
     OriGene Protein Over-expression Lysate for CABP1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CABP1   OriGene 3'-UTR Clone for CABP1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABP1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CABP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CABP1   OriGene Custom Protein Services for CABP1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABP1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABP1
     GenScript Custom Purified and Recombinant Proteins Services for CABP1 GenScript cDNA clones with any tag delivered in your preferred vector for CABP1
     GenScript Custom Assay Services for CABP1 GenScript Custom Superior Antibodies Services for CABP1
     GenScript Custom overexpressing Cell Line Services for CABP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CABP1 promoter
     Search Chromatin IP Primers for CABP1
     RT2 qPCR Primer Assay in human, mouse / rat CABP1
     GNC Network for CABP1
     SABiosciences PCR Arrays including human, mouse, rat CABP1
     Search Tocris compounds for CABP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CABP1 antibodies
     CABP1 proteins
     CABP1 lysates
     Antibodies for CABP1
     See all of Abcam's Antibodies, Kits and Proteins for CABP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CABP1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CABP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABP1
     SwitchGear 3'UTR luciferase reporter plasmids for CABP1
     SwitchGear Promoter luciferase reporter plasmids for CABP1
     ThermoFisher Antibodies for CABP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABP1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CABP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4