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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CABP1 Gene

protein-coding   GIFtS: 48
GCID: GC12P121078

Calcium Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium Binding Protein 11 2     Calcium Binding Protein 52
caldendrin1 2     Calcium-Binding Protein 12
calbrain1     CaBP13
CALBRAIN2     Calbrain3
HCALB_BR2     Caldendrin3

External Ids:    HGNC: 13841   Entrez Gene: 94782   Ensembl: ENSG000001577827   OMIM: 6055635   UniProtKB: Q9NZU73   

Export aliases for CABP1 gene to outside databases

Previous GC identifers: GC12M120133 GC12P120676 GC12P120861 GC12P119490 GC12P119541 GC12P118087


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CABP1 Gene:
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene
encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin.
The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein
inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing
voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity
of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor
potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results
in multiple transcript variants encoding disinct isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for CABP1 Gene: 
CABP1 (calcium binding protein 1) is a protein-coding gene. Diseases associated with CABP1 include amebiasis, and congenital stationary night blindness. GO annotations related to this gene include enzyme inhibitor activity and calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation
of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CABP1 gene promoter:
         Tal-1   HSF1 (long)   AP-4   Nkx2-5   Tal-1beta   E47   HSF1short   ITF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCABP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CABP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

CABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P121078:  view genomic region     (about GC identifiers)

Start:
121,078,355 bp from pter      End:
121,105,127 bp from pter
Size:
26,773 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7 (See protein sequence)
Recommended Name: Calcium-binding protein 1  
Size: 370 amino acids; 39838 Da
Subunit: Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3.
This binding is calcium dependent and the interaction correlates with calcium concentration. An additional
calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the
receptor. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts
with CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the
binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with
CACNA1D (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules
with MAP1LC3B. Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central
NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor
stimulation and prevents nuclear import of NSMF (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor;
Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near
the plasma membrane
Subcellular location: Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the
cytoskeletal structures
Subcellular location: Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor (Probable).
Note=S-CaBP1 is localized at or near the plasma membrane
Caution: The interaction with CACNA1A is described as calcium independent in PubMed:11865310 while it is shown to
be acutely calcium dependent in PubMed:14570872. PubMed:12032348 describes a stimulatory effect of CABP1 during
agonist-induced intracellular calcium signaling while PubMed:14570872 and PubMed:11865310 show an inhibitory
effect
6/7 PDB 3D structures from and Proteopedia for CABP1 (see all 7):
2K7B (3D)        2K7C (3D)        2K7D (3D)        2LAN (3D)        2LAP (3D)        3OX5 (3D)    
Secondary accessions: O95663 Q8N6H5 Q9NZU8
Alternative splicing: 4 isoforms:  Q9NZU7-4   Q9NZU7-1   Q9NZU7-2   Q9NZU7-3   (It is currently uncertain whether calbrain represent a spliced isoform)

Explore the universe of human proteins at neXtProt for CABP1: NX_Q9NZU7

Explore proteomics data for CABP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. The phosphorylation regulates the activity
  • View modification sites using PhosphoSitePlus (CABP1)
  • View neXtProt modification sites for NX_Q9NZU7

  • CABP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CABP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001028849.1  NP_004267.2  NP_112482.1  

    ENSEMBL proteins: 
     ENSP00000317310   ENSP00000288616   ENSP00000288615   ENSP00000398959  

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    Cloud-Clone Corp. Proteins for CABP1 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA19338761
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IDA19338761

    CABP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZU7

    ProtoNet protein and cluster: Q9NZU7

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Domain: EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium
    cooperatively and EF-2 binds neither calcium nor magnesium
    Similarity: Contains 4 EF-hand domains


    CABP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CABP1_HUMAN, Q9NZU7
    Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits
    agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent
    facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits
    inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of
    CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation
    of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By
    similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS9920909
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11865310
    GO:0008139nuclear localization sequence binding ISS--
    GO:0048306calcium-dependent protein binding IPI15980432
         
    CABP1 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CABP1 
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    SwitchGear 3'UTR luciferase reporter plasmidCABP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CABP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CABP1
        Visual Cycle in Retinal Rods


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CABP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for CABP1 (Q9NZU71, 3 ENSP000003173104) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 3, ENSP000002663764EBI-907894,EBI-1038838 I2D: score=4 STRING: ENSP00000266376
    CACNA1AO005553, ENSP000003533624I2D: score=1 STRING: ENSP00000353362
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    NMT1P304193, ENSP000002589604I2D: score=1 STRING: ENSP00000258960
    ITPR1Q146433, ENSP000004059344I2D: score=1 STRING: ENSP00000405934
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042308negative regulation of protein import into nucleus ISS--
    GO:0043086negative regulation of catalytic activity TAS9920909

    CABP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CABP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CABP1

    2 Novoseek inferred chemical compound relationships for CABP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,4,5 trisphosphate 41.9 2 19008222 (3), 19636832 (1), 19636926 (1)
    calcium 36.5 25 11865310 (4), 17224447 (3), 16049183 (3), 14570872 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about CABP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CABP1 gene (3 alternative transcripts): 
    NM_001033677.1  NM_004276.4  NM_031205.3  

    Unigene Cluster for CABP1:

    Calcium binding protein 1
    Hs.458482  [show with all ESTs]
    Unigene Representative Sequence: BC030201
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316803(uc001tyu.3) ENST00000288616 ENST00000351200 ENST00000453000(uc001tyv.3 uc001tyw.3 uc001tyx.3)
    ENST00000498082
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    Additional mRNA sequence: 

    AF169148.1 AF169149.1 BC030201.1 

    9 DOTS entries:

    DT.95265177  DT.100020539  DT.100646967  DT.92425494  DT.40207821  DT.444129  DT.92425497  DT.100646972 
    DT.91723595 

    24/63 AceView cDNA sequences (see all 63):

    NM_031205 BM666634 BQ188503 BM702046 BU735205 CR612944 CR602468 BC030201 
    BM716422 CR619895 BM696690 NM_004276 CB046141 AA364517 AK127203 BI754074 
    BI598798 AA775253 AL565119 AF169148 AA363865 BM932210 AF169149 AL537015 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CABP1 expression in normal human tissues (normalized intensities)      CABP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGCCCCAG
    CABP1 Expression
    About this image


    CABP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Pons
             Prefrontal Cortex   
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)

    See CABP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CABP1

    SOURCE GeneReport for Unigene cluster: Hs.458482

    UniProtKB/Swiss-Prot: CABP1_HUMAN, Q9NZU7
    Tissue specificity: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in
    brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CABP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cabp15 calcium binding protein 1   --   5 (55.99 cM) 115168689 
    chicken
    (Gallus gallus)
    Aves CABP16
    calcium binding protein 1
    53(a)
    1 ↔ 1
    15(9206727-9233056)
    lizard
    (Anolis carolinensis)
    Reptilia CABP16
    calcium binding protein 1
    71(a)
    1 ↔ 1
    GL343338.1(154659-161881)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW159042.12   -- 80.25(n)    AW159042.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cabp1a1 calcium binding protein 1a 77.41(n)
    87.5(a)
      449789  NM_001005962.1  NP_001005962.1 


    ENSEMBL Gene Tree for CABP1 (if available)
    TreeFam Gene Tree for CABP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CABP1 gene
    CALML32  CABP52  TNNC12  CALM32  CABP42  CABP22  CALM12  CALML62  
    TNNC22  CALML52  CABP72  CALML42  CALN12  CALM22  
    18/19 SIMAP similar genes for CABP1 using alignment to 2 protein entries:     CABP1_HUMAN (see all proteins) (see all similar genes):
    CABP5    CABP2    CABP4    CALM1    CALM2    CALML3
    CALN1    CALM3    CABP7    MYL1    CALML5    CETN1
    MYL2    MYL6    TNNC1    CETN2    TNNC2    CETN3

    CABP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/634 SNPs in CABP1 are shown (see all 634)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573245731,2
    C--118094755(+) TTTTT-/T/T   
       TTTTT
    GAGAT
    2 -- int1 cds11NA 2
    rs2002015441,2
    C--118102973(+) TGCGT-/GCGTGTG 3 -- int10--------
    rs286697631,2
    C,F--118102974(+) GCGTGT/CGTGTG 3 -- int13Minor allele frequency- C:0.33WA NA 6
    rs1407297331,2
    --120869913(+) ATTGAC/TTGACC 1 -- us2k10--------
    rs1891988911,2
    --120869920(+) GACCTC/TGAACT 1 -- us2k10--------
    rs1930604421,2
    --120870173(+) ATAAGC/TAAAAG 1 -- us2k10--------
    rs1384711871,2
    --120870182(+) AGAGGA/CACACA 1 -- us2k10--------
    rs1832638681,2
    --120870196(+) CCCAGC/TGCGGT 1 -- us2k10--------
    rs1875393891,2
    --120870197(+) CCAGCA/GCGGTG 1 -- us2k10--------
    rs1919664661,2
    --120870199(+) AGCGCA/GGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CABP1 (121078355 - 121105127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CABP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899557CNV Loss21882294
    nsv521928CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605563    OMIM disorders: --

    6 diseases for CABP1:    About MalaCards
    amebiasis    congenital stationary night blindness    night blindness    blindness
    retinitis    neuronitis


    CABP1 for disorders           About GeneDecksing


    Export disorders for CABP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CABP1 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CABP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. (PubMed id 10625670)1, 2, 3 Haeseleer F....Palczewski K. (2000)
    2. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. (PubMed id 9920909)1, 2, 3 Yamaguchi K....Hatase O. (1999)
    3. Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. (PubMed id 15980432)1, 2, 9 Zhou H.... Lee A. (2005)
    4. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. (PubMed id 19008222)1, 2, 9 Li C....Ames J.B. (2009)
    5. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. (PubMed id 11865310)1, 2, 9 Lee A....Catterall W.A. (2002)
    6. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. (PubMed id 14570872)1, 2, 9 Haynes L.P....Burgoyne R.D. (2004)
    7. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron- specific regulator of calcium channels. (PubMed id 16147998)1, 2 Wingard J.N.... Ames J.B. (2005)
    8. Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. (PubMed id 14685260)1, 2 Kasri N.N.... Roderick H.L. (2004)
    9. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. (PubMed id 15140941)1, 2 Zhou H....Lee A. (2004)
    10. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. (PubMed id 12032348)1, 2 Yang J.... Foskett J.K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9478 HGNC: 1384 AceView: CABP1 Ensembl:ENSG00000157782 euGenes: HUgn9478
    ECgene: CABP1 H-InvDB: CABP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CABP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CABP1 gene:
    Search GeneIP for patents involving CABP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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