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Aliases for CABP1 Gene

Aliases for CABP1 Gene

  • Calcium Binding Protein 1 2 3
  • Caldendrin 2 3 4
  • CALBRAIN 3 4
  • Calcium Binding Protein 5 3
  • Calcium-Binding Protein 1 3
  • Calbrain 2
  • HCALB_BR 3
  • CABP1 4

External Ids for CABP1 Gene

Previous GeneCards Identifiers for CABP1 Gene

  • GC12M120133
  • GC12P120861
  • GC12P119490
  • GC12P119541
  • GC12P121078
  • GC12P118087

Summaries for CABP1 Gene

Entrez Gene Summary for CABP1 Gene

  • Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CABP1 Gene

CABP1 (Calcium Binding Protein 1) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding and enzyme inhibitor activity. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CABP1 Gene

  • Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABP1 Gene

Genomics for CABP1 Gene

Regulatory Elements for CABP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CABP1 Gene

Start:
120,640,552 bp from pter
End:
120,667,324 bp from pter
Size:
26,773 bases
Orientation:
Plus strand

Genomic View for CABP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABP1 Gene

Proteins for CABP1 Gene

  • Protein details for CABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZU7-CABP1_HUMAN
    Recommended name:
    Calcium-binding protein 1
    Protein Accession:
    Q9NZU7
    Secondary Accessions:
    • O95663
    • Q8N6H5
    • Q9NZU8

    Protein attributes for CABP1 Gene

    Size:
    370 amino acids
    Molecular mass:
    39838 Da
    Quaternary structure:
    • Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This binding is calcium dependent and the interaction correlates with calcium concentration. An additional calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the receptor. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts with CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with CACNA1D (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B. Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import of NSMF. Interacts with C9orf9 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CABP1 Gene

    Alternative splice isoforms for CABP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CABP1 Gene

Proteomics data for CABP1 Gene at MOPED

Post-translational modifications for CABP1 Gene

  • Phosphorylated. The phosphorylation regulates the activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABP1 Gene

No data available for DME Specific Peptides for CABP1 Gene

Domains for CABP1 Gene

Gene Families for CABP1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CABP1 Gene

Suggested Antigen Peptide Sequences for CABP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZU7

UniProtKB/Swiss-Prot:

CABP1_HUMAN :
  • Q9NZU7
Domain:
  • EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with CABP1: view

Function for CABP1 Gene

Molecular function for CABP1 Gene

UniProtKB/Swiss-Prot Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).

Gene Ontology (GO) - Molecular Function for CABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity TAS 9920909
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 11865310
GO:0008139 nuclear localization sequence binding ISS --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with CABP1: view

Animal Model Products

CRISPR Products

miRNA for CABP1 Gene

miRTarBase miRNAs that target CABP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CABP1 Gene

Localization for CABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABP1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
Isoform L-CaBP1: Cytoplasm, cytoskeleton. Note=L-CaBP1 is associated most likely with the cytoskeletal structures.
Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S-CaBP1 is localized at or near the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABP1 Gene COMPARTMENTS Subcellular localization image for CABP1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 19338761
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CABP1: view

Pathways for CABP1 Gene

SuperPathways for CABP1 Gene

genes like me logo Genes that share pathways with CABP1: view

Pathways by source for CABP1 Gene

1 Qiagen pathway for CABP1 Gene

Gene Ontology (GO) - Biological Process for CABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010651 negative regulation of cell communication by electrical coupling IEA --
GO:0042308 negative regulation of protein import into nucleus ISS --
GO:0043086 negative regulation of catalytic activity TAS 9920909
GO:1901385 regulation of voltage-gated calcium channel activity --
GO:1901386 negative regulation of voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with CABP1: view

Compounds for CABP1 Gene

(2) Novoseek inferred chemical compound relationships for CABP1 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4,5 trisphosphate 41.9 5
calcium 36.5 15
genes like me logo Genes that share compounds with CABP1: view

Transcripts for CABP1 Gene

Unigene Clusters for CABP1 Gene

Calcium binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABP1 Gene

No ASD Table

Relevant External Links for CABP1 Gene

GeneLoc Exon Structure for
CABP1
ECgene alternative splicing isoforms for
CABP1

Expression for CABP1 Gene

mRNA expression in normal human tissues for CABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABP1 Gene

This gene is overexpressed in Brain - Cortex (12.8), Brain - Frontal Cortex (BA9) (11.6), and Brain - Anterior cingulate cortex (BA24) (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CABP1 Gene

SOURCE GeneReport for Unigene cluster for CABP1 Gene Hs.458482

mRNA Expression by UniProt/SwissProt for CABP1 Gene

Q9NZU7-CABP1_HUMAN
Tissue specificity: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum
genes like me logo Genes that share expressions with CABP1: view

In Situ Assay Products

Orthologs for CABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CABP1 36
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CABP1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABP1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabp1 16
Cabp1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CABP1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CABP1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabp1 35
  • 89.14 (n)
  • 91.14 (a)
chicken
(Gallus gallus)
Aves CABP1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CABP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12710 35
zebrafish
(Danio rerio)
Actinopterygii cabp1a 35
  • 77.41 (n)
  • 87.5 (a)
cabp1a 36
  • 73 (a)
OneToMany
cabp1b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11638 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cal-8 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10975 36
  • 31 (a)
ManyToMany
Species with no ortholog for CABP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CABP1 Gene

ENSEMBL:
Gene Tree for CABP1 (if available)
TreeFam:
Gene Tree for CABP1 (if available)

Paralogs for CABP1 Gene

Selected SIMAP similar genes for CABP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CABP1: view

Variants for CABP1 Gene

Sequence variations from dbSNP and Humsavar for CABP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs473121 -- 120,651,936(+) TTCCA(C/T)CCAGA intron-variant
rs478415 -- 120,663,873(+) ACTAC(G/T)GGATA intron-variant
rs495265 -- 120,656,858(+) ccatg(A/G)cactc intron-variant
rs496212 -- 120,656,752(+) tagct(A/G)ggcat intron-variant
rs503667 -- 120,650,947(+) TTTCT(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABP1 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899557 CNV Loss 21882294

Relevant External Links for CABP1 Gene

HapMap Linkage Disequilibrium report
CABP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABP1 Gene

Disorders for CABP1 Gene

No disorders were found for CABP1 Gene.

No data available for UniProtKB/Swiss-Prot for CABP1 Gene

Publications for CABP1 Gene

  1. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+- binding protein 1. (PMID: 11865310) Lee A. … Catterall W.A. (Nat. Neurosci. 2002) 3 4 23
  2. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. (PMID: 14570872) Haynes L.P. … Burgoyne R.D. (J. Biol. Chem. 2004) 3 4 23
  3. Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. (PMID: 15980432) Zhou H. … Lee A. (J. Biol. Chem. 2005) 3 4 23
  4. Structural insights into Ca2+-dependent regulation of inositol 1,4,5- trisphosphate receptors by CaBP1. (PMID: 19008222) Li C. … Ames J.B. (J. Biol. Chem. 2009) 3 4 23
  5. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. (PMID: 9920909) Yamaguchi K. … Hatase O. (J. Biol. Chem. 1999) 2 3 4

Products for CABP1 Gene

Sources for CABP1 Gene

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