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Aliases for CABLES2 Gene

Aliases for CABLES2 Gene

  • Cdk5 And Abl Enzyme Substrate 2 2 3 5
  • Interactor With CDK3 2 3 4
  • C20orf150 3 4
  • Ik3-2 3 4
  • Chromosome 20 Open Reading Frame 150 2
  • CDK5 And ABL1 Enzyme Substrate 2 3
  • DJ908M14.2 3

External Ids for CABLES2 Gene

Previous HGNC Symbols for CABLES2 Gene

  • C20orf150

Previous GeneCards Identifiers for CABLES2 Gene

  • GC20M061649
  • GC20U900156
  • GC20M060397
  • GC20M060963
  • GC20M057740

Summaries for CABLES2 Gene

GeneCards Summary for CABLES2 Gene

CABLES2 (Cdk5 And Abl Enzyme Substrate 2) is a Protein Coding gene. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CABLES1.

UniProtKB/Swiss-Prot for CABLES2 Gene

  • Unknown. Probably involved in G1-S cell cycle transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABLES2 Gene

Genomics for CABLES2 Gene

Regulatory Elements for CABLES2 Gene

Enhancers for CABLES2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062385 0.2 ENCODE 30.2 +20.0 19960 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 SLC30A9 ZNF416 ZNF143 ZNF207 SP3 LINC00029 CABLES2 LINC01056 MIR4758 ENSG00000226332 GATA5 MRGBP OSBPL2 GC20M062395 RPS21
GH20F062425 1.2 Ensembl ENCODE 22.4 -21.7 -21726 6.4 HDGF PKNOX1 ATF1 SIN3A ZNF207 FOS SP5 REST ZNF592 MBD2 CABLES2 LOC105372710 ARFGAP1 LAMA5 MIR4758 MIR1-1 MIR1-1HG MIR133A2 C20orf166-AS1 RBBP8NL
GH20F062405 0.2 ENCODE 22.3 +0.3 330 3.1 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CABLES2 GID8 ENSG00000226332 LOC105372709
GH20F062409 1.1 Ensembl ENCODE 18.4 -4.8 -4762 5.6 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF48 GLIS2 ELK1 CABLES2 LOC105372710 RBBP8NL
GH20F062935 1.1 ENCODE 10.8 -530.5 -530469 4.7 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LINC00029 GMEB2 GID8 LOC105372725 LINC01056 SLC17A9 DIDO1 MIR4758 CABLES2 ENSG00000226332
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CABLES2 on UCSC Golden Path with GeneCards custom track

Promoters for CABLES2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001839104 185 1401 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CABLES2 Gene

Chromosome:
20
Start:
62,388,630 bp from pter
End:
62,407,285 bp from pter
Size:
18,656 bases
Orientation:
Minus strand

Genomic View for CABLES2 Gene

Genes around CABLES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABLES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABLES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABLES2 Gene

Proteins for CABLES2 Gene

  • Protein details for CABLES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTV7-CABL2_HUMAN
    Recommended name:
    CDK5 and ABL1 enzyme substrate 2
    Protein Accession:
    Q9BTV7
    Secondary Accessions:
    • Q5JWL0
    • Q9BYK0

    Protein attributes for CABLES2 Gene

    Size:
    478 amino acids
    Molecular mass:
    52235 Da
    Quaternary structure:
    • Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity).

neXtProt entry for CABLES2 Gene

Post-translational modifications for CABLES2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABLES2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CABLES2 Gene

Domains & Families for CABLES2 Gene

Protein Domains for CABLES2 Gene

Suggested Antigen Peptide Sequences for CABLES2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BTV7

UniProtKB/Swiss-Prot:

CABL2_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CABLES2: view

No data available for Gene Families for CABLES2 Gene

Function for CABLES2 Gene

Molecular function for CABLES2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. Probably involved in G1-S cell cycle transition.

Phenotypes for CABLES2 Gene

GenomeRNAi human phenotypes for CABLES2:
genes like me logo Genes that share phenotypes with CABLES2: view

Animal Model Products

miRNA for CABLES2 Gene

miRTarBase miRNAs that target CABLES2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CABLES2 Gene

Localization for CABLES2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABLES2 Gene COMPARTMENTS Subcellular localization image for CABLES2 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CABLES2 Gene

Pathways & Interactions for CABLES2 Gene

genes like me logo Genes that share pathways with CABLES2: view

Pathways by source for CABLES2 Gene

Gene Ontology (GO) - Biological Process for CABLES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CABLES2: view

No data available for SIGNOR curated interactions for CABLES2 Gene

Transcripts for CABLES2 Gene

mRNA/cDNA for CABLES2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABLES2 Gene

Cdk5 and Abl enzyme substrate 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABLES2 Gene

No ASD Table

Relevant External Links for CABLES2 Gene

GeneLoc Exon Structure for
CABLES2
ECgene alternative splicing isoforms for
CABLES2

Expression for CABLES2 Gene

mRNA expression in normal human tissues for CABLES2 Gene

mRNA differential expression in normal tissues according to GTEx for CABLES2 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for CABLES2 Gene

This gene is overexpressed in Fetal heart (24.9), CD8 Tcells (14.1), Heart (11.2), Fetal Brain (9.5), and NK cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CABLES2 Gene



Protein tissue co-expression partners for CABLES2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CABLES2 Gene:

CABLES2

SOURCE GeneReport for Unigene cluster for CABLES2 Gene:

Hs.301040
genes like me logo Genes that share expression patterns with CABLES2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CABLES2 Gene

Orthologs for CABLES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CABLES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CABLES2 34 35
  • 99.54 (n)
rat
(Rattus norvegicus)
Mammalia Cables2 34
  • 86.18 (n)
dog
(Canis familiaris)
Mammalia CABLES2 34 35
  • 85.87 (n)
mouse
(Mus musculus)
Mammalia Cables2 34 16 35
  • 84.88 (n)
cow
(Bos Taurus)
Mammalia CABLES2 34 35
  • 84.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CABLES2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CABLES2 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CABLES2 34 35
  • 71.53 (n)
lizard
(Anolis carolinensis)
Reptilia CABLES2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cables2 34
  • 63.81 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148748 34
  • 62.38 (n)
cables2a 35
  • 52 (a)
OneToMany
cables2b 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6191 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71F9B.6 35
  • 19 (a)
OneToMany
Species where no ortholog for CABLES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CABLES2 Gene

ENSEMBL:
Gene Tree for CABLES2 (if available)
TreeFam:
Gene Tree for CABLES2 (if available)

Paralogs for CABLES2 Gene

Paralogs for CABLES2 Gene

(2) SIMAP similar genes for CABLES2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CABLES2: view

Variants for CABLES2 Gene

Sequence variations from dbSNP and Humsavar for CABLES2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10211851 -- 62,407,941(+) TGCCT(C/T)TGGAG upstream-variant-2KB
rs10671674 -- 62,406,436(+) AGGGC(-/TGAA)TGAAC intron-variant, upstream-variant-2KB
rs111434433 -- 62,393,341(+) GCTAC(A/G)GATTG intron-variant
rs111555121 -- 62,388,456(+) TTCTA(A/G)GAACT downstream-variant-500B, splice-acceptor-variant
rs111594110 -- 62,399,308(+) GGGGC(A/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CABLES2 Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv518n27 CNV loss 19166990
dgv7650n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
esv2422398 CNV duplication 17116639
esv2722809 CNV deletion 23290073
esv2722810 CNV deletion 23290073
esv2722811 CNV deletion 23290073
esv3429029 CNV duplication 20981092
nsv1143991 CNV deletion 24896259
nsv459065 CNV gain 19166990
nsv459067 CNV loss 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv586497 CNV loss 21841781
nsv586498 CNV loss 21841781
nsv586499 CNV loss 21841781
nsv586500 CNV gain 21841781
nsv828774 CNV loss 20364138
nsv828776 CNV gain 20364138
nsv834024 CNV gain 17160897
nsv953302 CNV deletion 24416366

Variation tolerance for CABLES2 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABLES2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CABLES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABLES2 Gene

Disorders for CABLES2 Gene

Relevant External Links for CABLES2

Human Genome Epidemiology (HuGE) Navigator
CABLES2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CABLES2

No disorders were found for CABLES2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CABLES2 Gene

Publications for CABLES2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. (PMID: 11955625) Sato H. … Matsuoka M. (Biochim. Biophys. Acta 2002) 3 22 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64

Products for CABLES2 Gene

Sources for CABLES2 Gene

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