CABLES2 Gene
protein-coding GIFtS: 47
GCID: GC20M060963
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Cdk5 and Abl enzyme substrate 2(Previous name: chromosome 20 open reading frame 150 )
(Previous symbol: C20orf150)
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Aliases
for CABLES2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cdk5 And Abl Enzyme Substrate 21 2 | | Interactor With CDK3 22 3 | | C20orf1501 2 3 | | Chromosome 20 Open Reading Frame 1501 | | DJ908M14.21 | | CDK5 And ABL1 Enzyme Substrate 22 | | Ik3-23 | | Ik3-23 |
Export aliases for CABLES2 gene to outside databasesPrevious GC identifers: GC20M061649 GC20U900156 GC20M060397 GC20M057740 |
Summaries
for CABLES2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CABL2_HUMAN, Q9BTV7Function: Unknown. Probably involved in G1-S cell cycle transition
|
Genomic Views
for CABLES2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018931.1 NC_000020.10 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CABLES2 gene promoter:
HOXA9 Elk-1 p53 FOXD1 AP-4 MZF-1 HEN1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for CABLES2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABLES2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33CABLES2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M060963: view genomic region
(about GC identifiers)
Start:
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60,963,686 bp from pter |
End:
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60,982,341 bp from pter |
Size:
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18,656 bases |
Orientation:
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minus strand |
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Proteins
for CABLES2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CABL2_HUMAN, Q9BTV7 (See
protein sequence)Recommended Name: CDK5 and ABL1 enzyme substrate 2 Size: 478 amino acids; 52235 Da
Subunit: Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity)
Secondary accessions: Q5JWL0 Q9BYK0Explore the universe of human proteins at neXtProt for CABLES2: NX_Q9BTV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTV7
CABLES2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112492.2
ENSEMBL proteins: ENSP00000279101 ENSP00000398535 Reactome Protein details: Q9BTV7
Human Recombinant Protein Products:
CABLES2 Antibody Products:
Assay Products for CABLES2: |
Protein
Domains /
Families
for CABLES2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CABLES2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BTV7ProtoNet protein and cluster: Q9BTV7 UniProtKB/Swiss-Prot: CABL2_HUMAN, Q9BTV7Similarity: Belongs to the cyclin family |
Function
for CABLES2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CABL2_HUMAN, Q9BTV7Function: Unknown. Probably involved in G1-S cell cycle transition
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CABLES2 (NM_031215) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABLES2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CABLES2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABLES2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0016538 | cyclin-dependent protein kinase regulator activity |
IEA | -- |
CABLES2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CABLES2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Factors involved in megakaryocyte development and platelet production | | | 2 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for CABLES2
CABLES2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CABLES2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for CABLES2 (Q9BTV73 ENSP000002791014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CABLES2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CABLES2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CABLES2
Search CenterWatch for drugs/clinical trials and news about CABLES2 / CABL2
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Transcripts
for CABLES2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CABLES2 gene: NM_031215.2 Unigene Cluster for CABLES2: Cdk5 and Abl enzyme substrate 2 Hs.301040 [show with all ESTs]Unigene Representative Sequence: NM_0312152 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000279101(uc002ycv.2) ENST00000453274
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CABLES2 (NM_031215) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABLES2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CABLES2 |
Additional cDNA sequence: BC003122.1 BC011196.2 6 DOTS entries: DT.91719000 DT.100643915 DT.214499 DT.100643916 DT.120811665 DT.91698231 24/107 AceView cDNA sequences (see all 107): AI989526 AI863009 BQ002579 AL121112 AI651123 BC011196 AI990539 AI970596 BG742726 CA420818 CR615670 AW274689 BU166894 BX093633 AI122833 AA219015 BF341966 BE672071 AI221777 BM668280 T17285 BE251491 AW305005 AA781124
GeneLoc Exon Structure
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Expression
for CABLES2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CABLES2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTGAGATT
About this image
See CABLES2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CABLES2
SOURCE GeneReport for Unigene cluster: Hs.301040
SABiosciences Custom PCR Arrays for CABLES2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABLES2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CABLES2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABLES2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABLES2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABLES2 |
Orthologs
for CABLES2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CABLES2 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for CABLES2 (if available)
TreeFam Gene Tree for CABLES2 (if available) |
Paralogs
for CABLES2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CABLES2 gene
- CABLES12
2 SIMAP similar genes for CABLES2 using alignment to 2 protein entries: CABL2_HUMAN (see all proteins):CABL1 CABLES1
CABLES2 for paralogs About GeneDecksing
|
Genomic Variants
for CABLES2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CABLES2 (60963686 - 60982341 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for CABLES2
9 CNVs: 29710 4106 5347 30131 30128 30130 50706 30127 53671 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABLES2 |
|
Disorders
/ Diseases
for CABLES2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CABLES2 for disorders About GeneDecksing
3  diseases for CABLES2: About MalaCardspancreatic cancer pancreatitis malaria
Human Genome Epidemiology (HuGE) Navigator: CABLES2 (1 document)
Export disorders for CABLES2 gene to outside databases
|
Publications
for CABLES2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CABLES2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CABLES2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. (PubMed id 11955625)1, 9 Sato H....Matsuoka M. (2002)
- Association of mitotic regulation pathway polymorphis ms with pancreatic cancer risk and outcome. (PubMed id 20056645)1 Couch F.J....McWilliams R.R. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. (PubMed id 14637168)1 Matsuoka M....Ogata E. (2003)
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External Searches for CABLES2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CABLES2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CABLES2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CABLES2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CABLES2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CABLES2 gene:
Search GeneIP for patents involving CABLES2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CABLES2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CABLES2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABLES2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABLES2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CABLES2 | | OriGene 3'-UTR Clone for CABLES2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABLES2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CABLES2 | | OriGene Custom Protein Services for CABLES2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABLES2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABLES2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABLES2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABLES2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABLES2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABLES2 |
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 |  |  |  | |
| | | | Search Tocris compounds for CABLES2 |
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 | | | CABLES2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABLES2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CABLES2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CABLES2 |
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