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Aliases for CABLES2 Gene

Aliases for CABLES2 Gene

  • Cdk5 And Abl Enzyme Substrate 2 2 3
  • Interactor With CDK3 2 3 4
  • C20orf150 3 4
  • Ik3-2 3 4
  • Chromosome 20 Open Reading Frame 150 2
  • DJ908M14.2 3

External Ids for CABLES2 Gene

Previous HGNC Symbols for CABLES2 Gene

  • C20orf150

Previous GeneCards Identifiers for CABLES2 Gene

  • GC20M061649
  • GC20U900156
  • GC20M060397
  • GC20M060963
  • GC20M057740

Summaries for CABLES2 Gene

GeneCards Summary for CABLES2 Gene

CABLES2 (Cdk5 And Abl Enzyme Substrate 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CABLES1.

UniProtKB/Swiss-Prot for CABLES2 Gene

  • Unknown. Probably involved in G1-S cell cycle transition

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABLES2 Gene

Genomics for CABLES2 Gene

Regulatory Elements for CABLES2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CABLES2 Gene

62,388,630 bp from pter
62,407,285 bp from pter
18,656 bases
Minus strand

Genomic View for CABLES2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CABLES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABLES2 Gene

Proteins for CABLES2 Gene

  • Protein details for CABLES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDK5 and ABL1 enzyme substrate 2
    Protein Accession:
    Secondary Accessions:
    • Q5JWL0
    • Q9BYK0

    Protein attributes for CABLES2 Gene

    478 amino acids
    Molecular mass:
    52235 Da
    Quaternary structure:
    • Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity).

neXtProt entry for CABLES2 Gene

Proteomics data for CABLES2 Gene at MOPED

Post-translational modifications for CABLES2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CABLES2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CABLES2 Gene

Domains & Families for CABLES2 Gene

Protein Domains for CABLES2 Gene


Suggested Antigen Peptide Sequences for CABLES2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family.
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CABLES2: view

No data available for Gene Families for CABLES2 Gene

Function for CABLES2 Gene

Molecular function for CABLES2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. Probably involved in G1-S cell cycle transition

Phenotypes for CABLES2 Gene

GenomeRNAi human phenotypes for CABLES2:
genes like me logo Genes that share phenotypes with CABLES2: view

Animal Model Products

CRISPR Products

miRNA for CABLES2 Gene

miRTarBase miRNAs that target CABLES2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABLES2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CABLES2 Gene

Localization for CABLES2 Gene

Subcellular locations from

Jensen Localization Image for CABLES2 Gene COMPARTMENTS Subcellular localization image for CABLES2 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CABLES2 Gene

Pathways & Interactions for CABLES2 Gene

genes like me logo Genes that share pathways with CABLES2: view

Pathways by source for CABLES2 Gene

Gene Ontology (GO) - Biological Process for CABLES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CABLES2: view

No data available for SIGNOR curated interactions for CABLES2 Gene

Drugs & Compounds for CABLES2 Gene

No Compound Related Data Available

Transcripts for CABLES2 Gene

mRNA/cDNA for CABLES2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CABLES2 Gene

Cdk5 and Abl enzyme substrate 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CABLES2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABLES2 Gene

No ASD Table

Relevant External Links for CABLES2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CABLES2 Gene

mRNA expression in normal human tissues for CABLES2 Gene

mRNA differential expression in normal tissues according to GTEx for CABLES2 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for CABLES2 Gene

This gene is overexpressed in Fetal heart (24.9), CD8 Tcells (14.1), Heart (11.2), Fetal Brain (9.5), and NK cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CABLES2 Gene

SOURCE GeneReport for Unigene cluster for CABLES2 Gene Hs.301040

genes like me logo Genes that share expression patterns with CABLES2: view

Protein tissue co-expression partners for CABLES2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CABLES2 Gene

Orthologs for CABLES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CABLES2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CABLES2 35
  • 84.51 (n)
  • 88.01 (a)
  • 64 (a)
(Canis familiaris)
Mammalia CABLES2 35
  • 85.87 (n)
  • 88.09 (a)
  • 80 (a)
(Mus musculus)
Mammalia Cables2 35
  • 84.88 (n)
  • 90.28 (a)
Cables2 16
Cables2 36
  • 84 (a)
(Pan troglodytes)
Mammalia CABLES2 35
  • 99.54 (n)
  • 99.77 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Cables2 35
  • 86.18 (n)
  • 92.49 (a)
(Monodelphis domestica)
Mammalia CABLES2 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia CABLES2 36
  • 76 (a)
(Gallus gallus)
Aves CABLES2 35
  • 71.53 (n)
  • 77.08 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia CABLES2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cables2 35
  • 63.81 (n)
  • 65.28 (a)
(Danio rerio)
Actinopterygii LOC100148748 35
  • 62.38 (n)
  • 67.88 (a)
cables2a 36
  • 52 (a)
cables2b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6191 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y71F9B.6 36
  • 19 (a)
Species with no ortholog for CABLES2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CABLES2 Gene

Gene Tree for CABLES2 (if available)
Gene Tree for CABLES2 (if available)

Paralogs for CABLES2 Gene

Paralogs for CABLES2 Gene

(2) SIMAP similar genes for CABLES2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CABLES2: view

Variants for CABLES2 Gene

Sequence variations from dbSNP and Humsavar for CABLES2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs747948 -- 62,389,245(-) ACTCA(A/G)CTTCA utr-variant-3-prime
rs747949 -- 62,389,066(-) TTTTT(C/T)CTACA utr-variant-3-prime
rs748036 -- 62,396,250(+) TGACA(C/G)GGGCA intron-variant
rs748037 -- 62,396,271(+) GGCTT(A/C)TGGAG intron-variant
rs927133 -- 62,397,053(+) GGCAC(C/T)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CABLES2 Gene

Variant ID Type Subtype PubMed ID
dgv4599n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
dgv4602n71 CNV Loss 21882294
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv470557 CNV Gain 18288195
nsv520024 CNV Loss 19592680
dgv518n27 CNV Loss 19166990
dgv4605n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913071 CNV Gain 21882294
dgv4606n71 CNV Loss 21882294
nsv828774 CNV Loss 20364138
nsv459067 CNV Loss 19166990
nsv913073 CNV Loss 21882294
nsv828776 CNV Gain 20364138
dgv4607n71 CNV Loss 21882294
esv2722809 CNV Deletion 23290073
nsv913075 CNV Loss 21882294
nsv913077 CNV Loss 21882294
esv2722810 CNV Deletion 23290073
esv2722811 CNV Deletion 23290073

Variation tolerance for CABLES2 Gene

Residual Variation Intolerance Score: 63.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABLES2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABLES2 Gene

Disorders for CABLES2 Gene

Relevant External Links for CABLES2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CABLES2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CABLES2 Gene

Publications for CABLES2 Gene

  1. ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. (PMID: 11955625) Sato H. … Matsuoka M. (Biochim. Biophys. Acta 2002) 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  5. Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. (PMID: 24737748) Whiffin N. … Dunlop M.G. (Hum. Mol. Genet. 2014) 67

Products for CABLES2 Gene

Sources for CABLES2 Gene

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