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Aliases for CABIN1 Gene

Aliases for CABIN1 Gene

  • Calcineurin Binding Protein 1 2 3 5
  • Calcineurin Inhibitor 3 4
  • CAIN 3 4
  • Calcineurin Binding Protein Cabin 1 3
  • KB-318B8.7 3
  • KIAA0330 4
  • PPP3IN 3

External Ids for CABIN1 Gene

Previous GeneCards Identifiers for CABIN1 Gene

  • GC22P021103
  • GC22P022732
  • GC22P024407
  • GC22P007355

Summaries for CABIN1 Gene

Entrez Gene Summary for CABIN1 Gene

  • Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]

GeneCards Summary for CABIN1 Gene

CABIN1 (Calcineurin Binding Protein 1) is a Protein Coding gene. Diseases associated with CABIN1 include complication after organ transplantation and lymphocele. Among its related pathways are Cellular Senescence and Packaging Of Telomere Ends. GO annotations related to this gene include protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for CABIN1 Gene

  • May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of its target genes.

Gene Wiki entry for CABIN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CABIN1 Gene

Genomics for CABIN1 Gene

Regulatory Elements for CABIN1 Gene

Promoters for CABIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CABIN1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CABIN1 gene promoter:

Genomic Location for CABIN1 Gene

Chromosome:
22
Start:
24,011,192 bp from pter
End:
24,178,628 bp from pter
Size:
167,437 bases
Orientation:
Plus strand

Genomic View for CABIN1 Gene

Genes around CABIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABIN1 Gene

Proteins for CABIN1 Gene

  • Protein details for CABIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J0-CABIN_HUMAN
    Recommended name:
    Calcineurin-binding protein cabin-1
    Protein Accession:
    Q9Y6J0
    Secondary Accessions:
    • G5E9F3
    • Q6PHY0
    • Q9Y460

    Protein attributes for CABIN1 Gene

    Size:
    2220 amino acids
    Molecular mass:
    246352 Da
    Quaternary structure:
    • Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.
    SequenceCaution:
    • Sequence=BAA20788.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CABIN1 Gene

    Alternative splice isoforms for CABIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CABIN1 Gene

Proteomics data for CABIN1 Gene at MOPED

Post-translational modifications for CABIN1 Gene

  • Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.
  • Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.
  • Ubiquitination at Lys 706 and Lys 1188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CABIN1 Gene

Domains & Families for CABIN1 Gene

Protein Domains for CABIN1 Gene

Suggested Antigen Peptide Sequences for CABIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6J0

UniProtKB/Swiss-Prot:

CABIN_HUMAN :
  • Contains 6 TPR repeats.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with CABIN1: view

No data available for Gene Families for CABIN1 Gene

Function for CABIN1 Gene

Molecular function for CABIN1 Gene

GENATLAS Biochemistry:
calcineurin binding protein 1,cDNA sequence,expressed in brain,>100kDa,related to murine procollagen alpha
UniProtKB/Swiss-Prot Function:
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of its target genes.

Gene Ontology (GO) - Molecular Function for CABIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity NAS 9655484
genes like me logo Genes that share ontologies with CABIN1: view

Phenotypes for CABIN1 Gene

genes like me logo Genes that share phenotypes with CABIN1: view

Animal Models for CABIN1 Gene

MGI Knock Outs for CABIN1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CABIN1 Gene

Localization for CABIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABIN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CABIN1 Gene COMPARTMENTS Subcellular localization image for CABIN1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CABIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CABIN1: view

Pathways & Interactions for CABIN1 Gene

genes like me logo Genes that share pathways with CABIN1: view

SIGNOR curated interactions for CABIN1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CABIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016568 chromatin modification IEA --
GO:0043086 negative regulation of catalytic activity NAS 9655484
GO:0060548 negative regulation of cell death IEA --
genes like me logo Genes that share ontologies with CABIN1: view

Drugs & Compounds for CABIN1 Gene

(11) Drugs for CABIN1 Gene - From: Novoseek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Tacrolimus (FK506) Pharma Macrolide calcineurin inhibitor,immunosuppressant 0

(2) Additional Compounds for CABIN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CABIN1 Gene

Compound Action Cas Number
Tacrolimus (FK506) Macrolide calcineurin inhibitor,immunosuppressant 104987-11-3
genes like me logo Genes that share compounds with CABIN1: view

Transcripts for CABIN1 Gene

Unigene Clusters for CABIN1 Gene

Calcineurin binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CABIN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24:
SP25:
SP26:

ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34 ^ 35 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: -
SP17: - - - - - -
SP18: - - - -
SP19: - - - - - -
SP20: - - - -
SP21:
SP22:
SP23:
SP24:
SP25: - - -
SP26:

ExUns: 36a · 36b ^ 37a · 37b · 37c ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b · 43c ^ 44a · 44b ^ 45 ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50
SP1:
SP2:
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for CABIN1 Gene

GeneLoc Exon Structure for
CABIN1
ECgene alternative splicing isoforms for
CABIN1

Expression for CABIN1 Gene

mRNA expression in normal human tissues for CABIN1 Gene

Protein differential expression in normal tissues from HIPED for CABIN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.6), CD8 Tcells (16.8), Bone marrow stromal cell (9.9), and Blymphocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CABIN1 Gene



SOURCE GeneReport for Unigene cluster for CABIN1 Gene Hs.517478

mRNA Expression by UniProt/SwissProt for CABIN1 Gene

Q9Y6J0-CABIN_HUMAN
Tissue specificity: Widely expressed in different tissues.
genes like me logo Genes that share expression patterns with CABIN1: view

Protein tissue co-expression partners for CABIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CABIN1 Gene

Orthologs for CABIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABIN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CABIN1 35
  • 83.94 (n)
  • 84.89 (a)
CABIN1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CABIN1 35
  • 89.56 (n)
  • 91.78 (a)
CABIN1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cabin1 35
  • 86.84 (n)
  • 89.94 (a)
Cabin1 16
Cabin1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CABIN1 35
  • 99.37 (n)
  • 99.37 (a)
CABIN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabin1 35
  • 87.01 (n)
  • 89.51 (a)
oppossum
(Monodelphis domestica)
Mammalia CABIN1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves CABIN1 35
  • 72.09 (n)
  • 77.27 (a)
CABIN1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CABIN1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cabin1 35
  • 70.18 (n)
  • 74.04 (a)
zebrafish
(Danio rerio)
Actinopterygii cabin1 35
  • 62.48 (n)
  • 58.98 (a)
CABIN1 (1 of 2) 36
  • 54 (a)
OneToMany
CABIN1 (2 of 2) 36
  • 44 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2094 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1916 36
  • 44 (a)
OneToOne
Species with no ortholog for CABIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CABIN1 Gene

ENSEMBL:
Gene Tree for CABIN1 (if available)
TreeFam:
Gene Tree for CABIN1 (if available)

Paralogs for CABIN1 Gene

(1) SIMAP similar genes for CABIN1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CABIN1: view

No data available for Paralogs for CABIN1 Gene

Variants for CABIN1 Gene

Sequence variations from dbSNP and Humsavar for CABIN1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5760185 - 24,038,417(+) AGTCT(A/G)CCAAA reference, missense
rs17004823 - 24,050,841(+) TTCAC(A/G)ATGTT intron-variant, reference, missense
rs9624393 - 24,060,075(+) CACAG(C/G)TGGAG reference, missense
rs9624395 - 24,064,130(+) CGAAG(A/C)GACAT reference, missense
rs17854874 - 24,072,436(+) ACACC(A/G)GATCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CABIN1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
nsv3578 CNV Loss 18451855
nsv469844 CNV Complex 16826518
nsv914628 CNV Loss 21882294
nsv914629 CNV Gain 21882294
nsv834156 CNV Gain+Loss 17160897
esv2724067 CNV Deletion 23290073
nsv834157 CNV Gain 17160897
esv1201518 CNV Insertion 17803354
nsv483072 CNV Loss 15286789
nsv508730 CNV Insertion 20534489
nsv914630 CNV Loss 21882294
nsv834158 CNV Gain 17160897
nsv528842 CNV Loss 19592680
nsv914631 CNV Loss 21882294
nsv914632 CNV Loss 21882294
nsv9881 CNV Loss 18304495

Variation tolerance for CABIN1 Gene

Residual Variation Intolerance Score: 8.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CABIN1 Gene

HapMap Linkage Disequilibrium report
CABIN1
Human Gene Mutation Database (HGMD)
CABIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CABIN1 Gene

Disorders for CABIN1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CABIN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
complication after organ transplantation
lymphocele
  • lymph cyst
spinal cord lymphoma
  • lymphoma of the spinal cord
invasive aspergillosis
  • aspergillosis invasive
pain disorder
  • paine syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CABIN1

Genetic Association Database (GAD)
CABIN1
Human Genome Epidemiology (HuGE) Navigator
CABIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CABIN1
genes like me logo Genes that share disorders with CABIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CABIN1 Gene

Publications for CABIN1 Gene

  1. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. (PMID: 9655484) Sun L. … Liu J.O. (Immunity 1998) 2 3 4 67
  2. Cabin1 restrains p53 activity on chromatin. (PMID: 19668210) Jang H. … Youn H.D. (Nat. Struct. Mol. Biol. 2009) 3 23
  3. Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. (PMID: 17172641) Jang H. … Youn H.D. (J. Biol. Chem. 2007) 3 23
  4. The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. (PMID: 15671033) RodrA-guez A. … Redondo J.M. (J. Biol. Chem. 2005) 3 23
  5. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PMID: 15902271) Pan F. … Liu J.O. (EMBO J. 2005) 3 23

Products for CABIN1 Gene

Sources for CABIN1 Gene

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