CABIN1 Gene
protein-coding GIFtS: 61
GCID: GC22P024407
|
|
calcineurin binding protein 1
| |
Aliases
for CABIN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcineurin Binding Protein 11 2 | | Calcineurin Inhibitor2 3 | | CAIN2 3 5 | | Calcineurin Binding Protein Cabin 12 | | PPP3IN1 2 | | Calcineurin-Binding Protein Cabin-12 | | KIAA03301 3 | | |
Export aliases for CABIN1 gene to outside databasesPrevious GC identifers: GC22P021103 GC22P022732 GC22P007355 |
Summaries
for CABIN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CABIN1:
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded bythis gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signaltransduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PESTmotifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing resultsin multiple transcript variants encoding two different isoforms. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cellreceptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKCand calcium signals
Gene Wiki entry for CABIN1
|
Genomic Views
for CABIN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CABIN1 gene promoter:
NF-1/L AML1a STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CABIN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABIN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23CABIN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P024407: view genomic region
(about GC identifiers)
Start:
|
24,407,642 bp from pter |
End:
|
24,574,596 bp from pter |
Size:
|
166,955 bases |
Orientation:
|
plus strand |
|
Proteins
for CABIN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0 (See
protein sequence)Recommended Name: Calcineurin-binding protein cabin-1 Size: 2220 amino acids; 246352 Da
Subunit: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts withcalcineurin. Interacts with MEF2B
Subcellular location: Nucleus
Sequence caution: Sequence=BAA20788.2; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for CABIN1:1N6J (3D)
Secondary accessions: Q9Y460Explore the universe of human proteins at neXtProt for CABIN1: NX_Q9Y6J0
Post-translational modifications:
Activated through PKC-mediated hyperphosphorylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6J0
CABIN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186210.1 NP_001188358.1 NP_036427.1
ENSEMBL proteins: ENSP00000394209 ENSP00000263119 ENSP00000384694 ENSP00000412389 ENSP00000381364 ENSP00000336991
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CABIN1 for ontologies About GeneDecksing
CABIN1 Antibody Products:
Assay Products for CABIN1: |
Protein
Domains /
Families
for CABIN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CABIN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6J0ProtoNet protein and cluster: Q9Y6J0 UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0Similarity: Contains 6 TPR repeats |
Function
for CABIN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cellreceptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKCand calcium signals Genatlas biochemistry entry for CABIN1:calcineurin binding protein 1,cDNA sequence,expressed in brain,>100kDa,related to murine procollagen alpha
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CABIN1 (NM_012295) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABIN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABIN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABIN1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004864 | protein phosphatase inhibitor activity |
NAS | 9655484 | | GO:0019904 | protein domain specific binding |
-- | -- | | GO:0030346 | protein phosphatase 2B binding |
-- | -- |
CABIN1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for CABIN1: Cabin1tm1.1Che Cabin1tm1Che
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cabin1):
CABIN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CABIN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Function of MEF2 in T lymphocytes | | | 2 | Nur77 Signaling in T-Cell | | | 3 | NFAT and Cardiac Hypertrophy | | | 4 | Role of Calcineurin-dependent NFAT signaling in lymphocytes | | | 5 | Calcium signaling in the CD4+ TCR pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CABIN1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CABIN1
1  GeneGo (Thomson Reuters) Pathway for CABIN1
2  BioSystems Pathways for CABIN1
CABIN1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CABIN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for CABIN1 (Q9Y6J02, 3 ENSP000002631194) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor signaling pathway |
NAS | 9655484 | | GO:0016568 | chromatin modification |
IEA | -- | | GO:0060548 | negative regulation of cell death |
-- | -- |
CABIN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CABIN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CABIN1 for compounds About GeneDecksing
 Browse Tocris compounds for CABIN1
1 HMDB Compound for CABIN1 About this table
10/12 Novoseek chemical compound relationships for CABIN1 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rapamycin |
80 |
24 |
18793727 (2), 16975081 (1), 17713429 (1), 19923086 (1) (see all 18) |
| mycophenolate mofetil |
76.3 |
8 |
19775321 (1), 18282242 (1), 18992054 (1), 12709080 (1) (see all 6) |
| tacrolimus |
75.4 |
15 |
11150994 (1), 16182764 (1), 11558493 (1), 15619640 (1) (see all 10) |
| thymoglobulin |
75.4 |
2 |
18657156 (1), 16110819 (1) |
| cyclosporin a |
70.1 |
15 |
18574772 (1), 11150994 (1), 16182764 (1), 11558493 (1) (see all 10) |
| mycophenolic acid |
66.5 |
1 |
14508385 (1) |
| basiliximab |
63.1 |
1 |
18282242 (1) |
| alemtuzumab |
48.1 |
2 |
16974888 (1), 16110819 (1) |
| steroid |
34.9 |
4 |
16974888 (1), 12717217 (1), 16975489 (1), 16249744 (1) |
| azathioprine |
11.2 |
1 |
12709080 (1) |
Search CenterWatch for drugs/clinical trials and news about CABIN1 / CABIN
|
Transcripts
for CABIN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CABIN1 gene (3 alternative transcripts): NM_001199281.1 NM_001201429.1 NM_012295.3 Unigene Cluster for CABIN1: Calcineurin binding protein 1 Hs.517478 [show with all ESTs]Unigene Representative Sequence: NM_00119928113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454754 ENST00000263119(uc010guk.1 uc002zzi.1 uc021wnc.1 uc002zzj.1)
ENST00000405822(uc010gul.1) ENST00000445422 ENST00000398319(uc002zzk.2 uc002zzl.2)
ENST00000474981 ENST00000484593 ENST00000496016 ENST00000467937 ENST00000337989(uc002zzm.1)
ENST00000495121 ENST00000485008 ENST00000459824
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CABIN1 (NM_012295) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CABIN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABIN1 |
Additional cDNA sequence: AB002328.2 AF072441.1 AK127950.1 AK307522.1 AL390166.1 BC013099.1 BC021929.1 BC028969.1 BC041659.1 BC054497.1 13 DOTS entries: DT.95310233 DT.447375 DT.97838462 DT.92062145 DT.95286036 DT.92450991 DT.97847423 DT.95310218 DT.86854770 DT.86854771 DT.91669963 DT.95134074 DT.120672683 24/245 AceView cDNA sequences (see all 245): BM927150 AF072441 AW450279 CK299290 BQ278669 CN481110 CK299251 AL703593 BM685136 CA431189 CB852081 CA390121 AI524517 BC013099 BU620361 AA322823 AI075184 CA308918 BX644449 BE274822 CK000636 H55379 Z40231 BM709869
GeneLoc Exon Structure
5/26 Alternative Splicing Database (ASD) splice patterns (SP) for CABIN1 (see all 26) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | · | 32c | ^ | 33 | ^ | 34 | ^ | 35 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 36a | · | 36b | ^ | 37a | · | 37b | · | 37c | ^ | 38a | · | 38b | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43a | · | 43b | · | 43c | ^ | 44a | · | 44b | ^ | 45 | ^ | 46 | ^ | 47 | ^ | 48 | ^ | 49a | · | 49b | ^ | 50 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CABIN1
|
Expression
for CABIN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CABIN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGGTGGA
About this image
See CABIN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CABIN1
SOURCE GeneReport for Unigene cluster: Hs.517478
UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0Tissue specificity: Widely expressed in different tissues
SABiosciences Custom PCR Arrays for CABIN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABIN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CABIN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABIN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABIN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABIN1 |
Orthologs
for CABIN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CABIN1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for CABIN1 (if available)
TreeFam Gene Tree for CABIN1 (if available) |
Paralogs
for CABIN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CABIN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CABIN1 (24407642 - 24574596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CABIN1
5 CNVs: 0235 0688 36015 5180 36016
Human Gene Mutation Database (HGMD): CABIN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABIN1 |
|
Disorders
/ Diseases
for CABIN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CABIN1 for disorders About GeneDecksing
OMIM gene information: 604251
OMIM disorders: --
20/36  diseases for CABIN1 (see all 36): About MalaCardsadult-onset still's disease thrombotic thrombocytopenic purpura focal segmental glomerulosclerosis hemolytic-uremic syndrome
invasive aspergillosis lymphocele bronchiolitis obliterans arteriolosclerosis
aspergillosis purpura atopic dermatitis acute lymphoblastic leukemia
glomerulosclerosis lymphoblastic leukemia kaposi's sarcoma proteinuria
paine syndrome cystic fibrosis osteonecrosis dermatitis
11 diseases from the University of Copenhagen DISEASES database for CABIN1:Kidney failure Proteinuria Thrombotic thrombocytopenic purpura Hypertension
Pain disorder Lymphocele Diabetes mellitus Atopic dermatitis
Liver disease Bronchiolitis obliterans Nephritis 9 Novoseek disease relationships for CABIN1 gene About this table
Genetic Association Database (GAD): CABIN1
Human Genome Epidemiology (HuGE) Navigator: CABIN1 (7 documents)
Export disorders for CABIN1 gene to outside databases
|
Publications
for CABIN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CABIN1 gene, integrated from 9 sources (see all 135):
(articles sorted by number of sources associating them with CABIN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. (PubMed id 9655484)1, 2, 3 Sun L.... Liu J.O. (1998)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. (PubMed id 12700764)1, 2, 9 Han A.... Chen L. (2003)
- Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
- Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)1, 2 Tagami H.... Nakatani Y. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PubMed id 15902271)1, 9 Pan F....Liu J.O. (2005)
- Cabin1 restrains p53 activity on chromatin. (PubMed id 19668210)1, 9 Jang H....Youn H.D. (2009)
- Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. (PubMed id 17172641)1, 9 Jang H....Youn H.D. (2007)
- The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. (PubMed id 15671033)1, 9 Rodriguez A....Redondo J.M. (2005)
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External Searches for CABIN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CABIN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CABIN1 gene
(According to HUGE)
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Specialized Databases showing CABIN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CABIN1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CABIN1 gene:
Search GeneIP for patents involving CABIN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CABIN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CABIN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CABIN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CABIN1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CABIN1 | | OriGene 3'-UTR Clone for CABIN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CABIN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CABIN1 | | OriGene Custom Protein Services for CABIN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CABIN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CABIN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CABIN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CABIN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CABIN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CABIN1 |
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| | | | Search Tocris compounds for CABIN1 |
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 | | | CABIN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CABIN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CABIN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CABIN1 |
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